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Dissertations / Theses on the topic 'Human Profile'

Author: Grafiati

Published: 9 March 2023

Last updated: 19 July 2025

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1

Devaraj, Revathy. "Validation of the Human Activity Profile." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp01/MQ52893.pdf.

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2

Burden, Helena P. "Prostate cell profile in human male urine." Thesis, University of Bristol, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.539764.

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3

Trudel, Nathalie. "Gene expression profile in human prostate cancer cell lines." Thesis, McGill University, 2000. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=33449.

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Since the beginning of this work in 1998, it is estimated that 1780 men died of prostate cancer in Quebec. Molecular analysis of prostate cancer will eventually lead to the discovery of key genes involved in its onset and progression. The present project was to compare gene expression profiles in human non-tumorigenic versus tumorigenic prostate cell lines generated in our laboratory. A putative tumor suppressor gene present on 12q13 would be responsible for the non-tumorigenic phenotype of one cell line as discovered earlier by our team.<br>In order to compare gene expression patterns, expres

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4

Feng, Huichen. "Gene expression profile in human trophoblast and gestational trophoblastic disease." Click to view the E-thesis via HKUTO, 2004. http://sunzi.lib.hku.hk/hkuto/record/B31384742.

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5

Warasiha, Benjamart. "Cytochrome P450 mRNA profile in human breast cancer cell lines." Thesis, Robert Gordon University, 2008. http://hdl.handle.net/10059/364.

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Cytochrome P450 enzymes (P450s) are involved in cancer development and treatment due to their roles in the oxidative metabolism of various endogenous (e.g. oestrogen) and exogenous (e.g. tamoxifen) compounds. It is well-known that intermediate P450 metabolites derived from oestrogen metabolism are associated with breast carcinogenesis. The main aim of this project was to profile the cytochrome P450 and P450-regulatory nuclear receptor mRNAs in a series of breast cancer cell lines (BCCs) and compare this profile with normal breast cells. This study used the qualitative reverse transcriptasepoly

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Feng, Huichen, and 馮會臣. "Gene expression profile in human trophoblast and gestational trophoblastic disease." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2004. http://hub.hku.hk/bib/B31384742.

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7

Chang, Yung Ping. "Gesture Analysis for Human-Computer Interface Using Profile-Matching Stereo Vision." BYU ScholarsArchive, 2013. https://scholarsarchive.byu.edu/etd/3729.

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This thesis presents a novel profile shape matching stereo vision algorithm. This algorithm is able to obtain 3D information in real time from a pair of stereo images. This algorithm produces the 3D information by matching the profile intensity shapes on the same row of the two images from a stereo image pair. The advantage of this profile shape matching algorithm is that the detection of correspondences relies on intensity profile shape not on intensity values, which subject to lighting variations. The user can choose an interval of disparity, and then an object in a desired distance range ca

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8

Arney, Christle Shannon. "Morphological variation in the human tibia and its potential for profile estimation in human skeletal remains." Thesis, Wichita State University, 2011. http://hdl.handle.net/10057/5159.

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This study evaluates the existence and degree of human variation as it is represented by the morphology of the tibia. Specifically, this research is undertaken in order to quantitatively address the morphological variation of this skeletal element to reveal the inherent variation within the individual, while also evaluating the discrepancies that result due to the sex and age of an individual. It also explores the interaction of tibial morphology with living stature, assessing the ability of the quantified portions of the bone to explain stature. In order to investigate this variation, the tib

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9

Harrington, Carl R. "Design and application of a DNA microarray to profile human gut flora." Thesis, University of East Anglia, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.435018.

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10

Popova, I. S. "Usage of immunohistochemiсal markers for complex diagnosing of human breast cancer profile". Thesis, БДМУ, 2021. http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/18464.

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11

Nilsson, Felix. "Joint Human-Machine Exploration of Industrial Time Series Using the Matrix Profile." Thesis, Högskolan i Halmstad, CAISR Centrum för tillämpade intelligenta system (IS-lab), 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:hh:diva-44717.

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Technological advancements and widespread adaptation of new technology in industry have made industrial time series data more available than ever before. This trend is expected to continue, especially with the introduction of Industry 4.0, where the goal is to connect everything on the industry floor to the cloud and the Industrial Internet of Things. With this development grows the need for versatile methods for mining industrial time series data. Time series motif discovery is a sub-set of data mining and is about finding interesting patterns in time series data. The state of the art in time

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12

Clark, Christopher Anderson. "Retinal profile and structural differences between myopes and emmetropes." Thesis, Indiana University, 2014. http://pqdtopen.proquest.com/#viewpdf?dispub=3616989.

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<p> Refractive development has been shown to be influenced by optical defocus in the eye and the interpretation of this signal appears to be localized in the retina. Optical defocus is not uniform across the retina and has been suggested as a potential cause of myopia development. Specifically hyperopic focus, i.e. focusing light behind the retina, may signal the eye to elongate, causing myopia. This non-uniform hyperopic signal appears to be due to the retinal shape. Ultimately, these signals are detected by the retina in an as yet undetermined manner. The purpose of this thesis is to examine

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13

Zschaler, Josefin, Juliane Dorow, Louisa Schöpe, Uta Ceglarek, and Jürgen Arnhold. "Impact of Myeloperoxidase-derived oxidants on the product profile of human 5-Lipoxygenase." Universitätsbibliothek Leipzig, 2016. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-201824.

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Human 5-lipoxygenase (5-LOX) oxidizes arachidonic acid to 5S-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-HpETE) and leukotriene (LT) A4. In neutrophils, LTA4 is further converted to the potent chemoattractant LTB4. These cells also contain the heme enzyme myeloperoxidase (MPO), which produces several potent oxidants such as hypochlorous acid (HOCl), which are involved in pathogen defense and immune regulation. Here, we addressed the question whether MPO-derived oxidants are able to affect the activity of 5-LOX and the product profile of this enzyme. Human 5-LOX was incubated with increa

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Zschaler, Josefin, Juliane Dorow, Louisa Schöpe, Uta Ceglarek, and Jürgen Arnhold. "Impact of Myeloperoxidase-derived oxidants on the product profile of human 5-Lipoxygenase." Free radical biology & medicine (2015) 85, S. 148-156, 2015. https://ul.qucosa.de/id/qucosa%3A14677.

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Human 5-lipoxygenase (5-LOX) oxidizes arachidonic acid to 5S-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-HpETE) and leukotriene (LT) A4. In neutrophils, LTA4 is further converted to the potent chemoattractant LTB4. These cells also contain the heme enzyme myeloperoxidase (MPO), which produces several potent oxidants such as hypochlorous acid (HOCl), which are involved in pathogen defense and immune regulation. Here, we addressed the question whether MPO-derived oxidants are able to affect the activity of 5-LOX and the product profile of this enzyme. Human 5-LOX was incubated with increa

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15

Childs, Brian Richard. "Use of Personality Profile Assessments in the Construction Industry." BYU ScholarsArchive, 2015. https://scholarsarchive.byu.edu/etd/5634.

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Various industries are using personality profile assessments as tools to help reduce employee turnover. Employee turnover is a continuing challenge in the construction industry that has negative effects on construction companies. Research found that it was difficult to know if companies in the construction industry are using personality profile assessments as a tool to help reduce employee turnover. After understanding that other industries were using personality profile assessments in their hiring, promoting, team building and leadership development to reduce turnover, it was desired to under

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16

Robinson, Ailie. "An investigation into the effects of Plasmodium parasite infection on the human odour profile." Thesis, London School of Hygiene and Tropical Medicine (University of London), 2017. http://researchonline.lshtm.ac.uk/4539377/.

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Some studies suggest that Plasmodium parasites can change the attractiveness of their vertebrate hosts to Anopheles vectors. This is suggestive of parasite manipulation, where the parasite alters a host phenotype to the parasite’s own fitness benefit. In this instance, Plasmodium parasites may benefit from increased transmission via a greater number of vector-host contacts. Despite evidence that variation in human host attractiveness to biting insects is manifest through differences in the human odour profile (volatile compounds produced by the skin), the association between odour profile and

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17

Fraser, Isla. "Establishing the relationship between environmental sources and the stable isotope profile of human tissues." Thesis, Queen's University Belfast, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.479419.

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18

FANTINI, VALENTINA. "Functional analysis and transcriptome profile of meninges and skin fibroblasts from human aged donors." Doctoral thesis, Università degli studi di Pavia, 2021. http://hdl.handle.net/11571/1446317.

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19

Aly, Amir. "Towards an Interactive Human-Robot Relationship : Developing a Customized Robot's Behaviour to Human's Profile." Palaiseau, École nationale supérieure de techniques avancées, 2014. https://pastel.hal.science/tel-01128923.

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L'importance de considérer l'émotion dans l'interaction homme-robot comme base pour le comportement généré du robot, est la nature floue de l'émotion. Cela peut entraîner le robot à générer un comportement inapproprié au contexte de l'interaction en méconnaissant une émotion observée. Cela ouvre la porte vers une nouvelle méthodologie floue à base pour détecter l'émotion plus précisément. Cette méthodologie décide si l'émotion observée a besoin d'un nouveau comportement à synthétiser au cas où elle constitue une nouvelle classe non apprise auparavant, ou si elle peut être attribuée à un compor

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Garnett, Shaun. "Generating a proteomic profile of neurogenesis, through the use of human foetal neural stem cells." Doctoral thesis, Faculty of Science, 2019. http://hdl.handle.net/11427/31143.

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Introduction Neurogenesis, the development of new neurons, starts soon after the formation of the neural tube and is largely completed by birth. Development of the brain after birth is mainly reliant on the formation of new connections between surviving neurons. However, adult neurogenesis does continue in the subgranular zone of the hippocampus from quiescent adult neural stem cells. Traditionally neural stem cells were cultured as neurospheres, a heterogeneous agglomeration of neural cells at various stages of differentiation. This heterogeneity prevented accurate quantitative analysis. In 2

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21

Frear, Susan W. "A Construct Validity Analysis of the Work Perceptions Profile Data." Thesis, University of North Texas, 2015. https://digital.library.unt.edu/ark:/67531/metadc799499/.

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As work environments become more complex and demanding, organizations are becoming more interested in measuring the impact of their human resource development programs and initiatives. With this increased attention on data and measurement, human resource professionals have been encouraged to utilize data collection and data analysis techniques to make more objective and rationale human capital decisions and to verify business impact. As a result, the human resource profession has seen a significant increase in the use of surveys to measure anything from training effectiveness to the efficacy o

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Dumont, Larry Joe. "Human cytomegalovirus reactivation following seasonal allergen exposure and switch to T-helper cell type 2 profile /." Connect to full text at ProQuest Digital Dissertations. IP filtered, 2005.

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Thesis (Ph.D. in Clinical Sciences) -- University of Colorado at Denver and Health Sciences Center, 2005.<br>Typescript. Includes bibliographical references (leaves 140-156). Free to UCDHSC affiliates. Online version available via ProQuest Digital Dissertations;

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23

Ding, Peihui, and 丁佩惠. "Expression profile, molecular regulation and immuno-inflammatory function of LPS-binding protein in human oral keratinocytes." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2012. http://hub.hku.hk/bib/B49617795.

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Lipopolysaccharide (LPS)-binding protein (LBP) functions as a crucial molecule in innate immune responses to bacterial challenge. Our recent study shows the expression of LBP in human gingiva and its significant association with periodontal condition. Porphyromonas gingivalis is a keystone periodontopathogen with its LPS as a major virulence factor strongly involved in periodontal pathogenesis. Recent study has discovered that P. gingivalis LPS displays a significant lipid A structural heterogeneity. The present study investigated i) the expression profile of LBP in human oral keratinocytes (

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24

Gravina, Lucia Concetta. "Imunohistochemical profile of the neuroblasts of the peripheral sympathetic nervous system and human neuroblastoma of childhood." Doctoral thesis, Università di Catania, 2014. http://hdl.handle.net/10761/1537.

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ABSTRACT I focused on the analysis of a protein involved in the development of the peripheral nervous system: the Wilms tumor1 (WT1). My thesis is divided into two experimental phases: I) spatio-temporal distribution of WT1 during human embryonic development, II) expression and functional roles of WT1 during development of the peripheral sympathetic nervous system and gastrointestinal tract. The Wilms tumor (WT1) gene and its protein product are known to exhibit a dynamic expression profile during development and in the adult organism. Apart from a nuclear expression observed in the urogenit

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25

MERAVIGLIA, VIVIANA. "Human mesenchymal stromal cells: how the tissue of origin influences plastic properties and microRNA expression profile." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2014. http://hdl.handle.net/10281/51144.

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MicroRNAs are key modulators at molecular level in different biological processes, including determination of cell fate and differentiation. Herein, microRNA expression profiling experiments were performed on syngeneic cardiac and bone marrow mesenchymal stromal cells cultured in standard growth medium and then in vitro exposed to adipogenic, osteogenic, cardiomyogenic and endothelial differentiation media. Analysis identified a tissue-specific microRNA signature composed by 16 microRNAs that univocally discriminated cell type of origin and that were completely unaffected by in vitro different

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Llewellyn, Bonny C. "A Profile and Analysis of Repeat Bankruptcy Petitioners in the District of Utah 1984-2004." DigitalCommons@USU, 2005. https://digitalcommons.usu.edu/etd/2849.

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The purpose of this study was to describe the incidence of repeat filers in Utah and estimate the extent that repeat filers may be abusing the bankruptcy system. This study sought to develop a profile of repeat filers . Demographic and financial variables were examined to detem1ine their association with abuser/nonabuser status. In this study, abuse of bankruptcy was characterized only by the timing and number of filings over 20 years. Debtors with three filings in a 2-year period or less and debtors with four or more total filings were classified as abusers. Nonabusers were defined as debtors

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Wollin, Judy A. "Assessing disability : the reliability and validity of the multiple sclerosis disability profile." Thesis, Queensland University of Technology, 1998. https://eprints.qut.edu.au/36737/1/36737_Digitised%20Thesis.pdf.

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The assessment of people with disabilities is complex. The priorities adopted and issues addressed vary. The Multiple Sclerosis Disability Profile was developed and is currently used to assess people with MS in Australia. However, little is known about its psychometric properties and people with MS have not had a previous opportunity to comment on its relevance to them. Therefore the reliability and validity of the Disability Profile was assessed using widely used assessment methods and the views of people with MS. Standard methods for assessing the characteristics of assessment scales were us

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Tuccitto, Alessandra. "pH regulatory molecules in the tumour microenvironment : modulators of aggressiveness and immune profile of human hepatocellular carcinoma." Thesis, Open University, 2018. http://oro.open.ac.uk/55985/.

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<b>Background:</b> Hepatocellular carcinoma (HCC) arises in an inflammatory, hypoxic/acidic microenvironment that favours tumour progression and fosters immunosuppression. Tumour cells survive this hostile environment by over-expressing pH regulatory molecules such as carbonic anhydrase (CA) IX, XII and V-ATPase complex, but the relevance of these molecules in HCC is poorly defined. <b>Aim:</b> The aim of this study was to dissect the relationships between pH regulatory molecules and the aggressive behaviour of malignant hepatocytes, and to evaluate how pH regulatory molecules influence the im

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Urquhart, Paula, Susan M. Parkin, and Anna Nicolaou. "Profile of eicosanoids produced by human saphenous vein endothelial cells and the effect of dietary fatty acids." Harcourt, 2009. http://hdl.handle.net/10454/4038.

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no<br>Human saphenous vein endothelial cells (HSVECs) derived from primary cultures of adult human veins constitute an excellent in vitro model for studying human endothelial metabolism. In this study we report the14C-labelled prostanoid profile of HSVECs under resting and stimulated conditions and the effect of the n-3 polyunsaturated fatty acids eicosapentaenoic acid and docosahexaenoic acid on them. Results indicate that HSVECs while under resting conditions produce mainly prostaglandin F2 ¿(PGF2 ¿). After stimulation with calcium ionophore A23187, the cells were found to synthesise PGI2, P

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Fiorelli, S. "BIOCHEMICAL AND FUNCTIONAL PROFILE OF SPONTANEOUSLY DIFFERENTIATED HUMAN MONOCYTE-DERIVED MACROPHAGES IN PATIENTS WITH ISCHEMIC HEART DISEASE." Doctoral thesis, Università degli Studi di Milano, 2018. http://hdl.handle.net/2434/544434.

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Background: Atherosclerosis is a chronic inflammatory disease in which oxidative stress and macrophages play fundamental roles. Macrophages are heterogeneous cells in term of morphology and function and the prevalence of a specific morpho-phenotype may influence the progression or the regression of the plaque. Human coronary plaque macrophages are not easily obtainable and monocyte-derived macrophages (MDMs) are widely accepted as a good surrogate. Our previous study has reported that healthy subjects show two dominant MDM morphotypes, spindle and round, present in the same percentage. Aim: T

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MEREGALLI, CHIARA. "STUDY OF MULTIPOTENT RENAL PKHHIGH STEM-LIKE CELLS, ISOLATED FROM HUMAN NEPHROSPHERES: REGENERATIVE ABILITIES AND TRANSCRIPTOMIC PROFILE." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2018. http://hdl.handle.net/10281/199041.

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Il meccanismo alla base della riparazione di un danno a cellule renali è ancora oggi oggetto di dibattito e potrebbe coinvolgere sia cellule terminalmente differenziate che l'esistenza di cellule staminali multipotenti quiescenti. Sfruttando il saggio di formazione di sfere e la tecnica del FACS sorting, il nostro gruppo ha isolato una popolazione di cellule marcate col clorante PKH26 che avessero caratteristiche di cellule staminali renali adulte (PKHhigh). In precedenza abbiamo valutato la capacità di queste cellule di differenziare in vitro in lineage epiteliale, podocitico ed endoteliale.

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32

Mayta-Tristan, Percy, Elías Reneé Pereyra, Juan José Montenegro-Idrogo, Christian R. Mejia, Berrospi Fiorella Inga, and Holguín Edward Mezones. "Profile and professional expectations of medical students from 11 Latin American countries: the Red-LIRHUS project." Biomed Central Ltd, 2017. http://hdl.handle.net/10757/622009.

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Background Latin America is undergoing a human resource crisis in health care in terms of labor shortage, misdistribution and poor orientation to primary care. Workforce data are needed to inform the planning of long-term strategies to address this problem. This study aimed to evaluate the academic and motivational profile, as well as the professional expectations, of Latin American medical students. Results We conducted an observational, cross-sectional, multi-country study evaluating medical students from 11 Spanish-speaking countries in 2011–2012. Motivations to study medicine, mig

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Archontoulis, Fiona L. "The implementation of a workload allocation system in pursuit of employee health outcomes." Thesis, Griffith University, 2020. http://hdl.handle.net/10072/395540.

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The impact of increasing global competitiveness and the ensuing decisions taken by organisations to adjust, often have negative impacts on the health and wellbeing of employees. Increasing workloads, time and resourcing constraints are contributing factors to changing dynamics and psychosocial characteristics in many workplaces. There is ample evidence about the cost to organisations, society and individuals when financial performance objectives are prioritised over employee health and well-being. Human resource management (HRM) studies commonly address organisational performance outcomes over

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Kepenekci, Burcu. "Human Activity Recognition By Gait Analysis." Phd thesis, METU, 2011. http://etd.lib.metu.edu.tr/upload/12613089/index.pdf.

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This thesis analyzes the human action recognition problem. Human actions are modeled as a time evolving temporal texture. Gabor filters, which are proved to be a robust 2D texture representation tool by detecting spatial points with high variation, is extended to 3D domain to capture motion texture features. A well known filtering algorithm and a recent unsupervised clustering algorithm, the Genetic Chromodynamics, are combined to select salient spatio-temporal features of the temporal texture and to segment the activity sequence into temporal texture primitives. Each activity sequence is repr

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Mannem, Chandana. "IN-QUEST OF BIOMARKERS FOR ALZHEIMER’S DISEASE AND PHARMACOKINETIC PROFILE OF ANTICANCER AGENTS USING LC-MS IN HUMAN PLASMA." Cleveland State University / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=csu1579470084334844.

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Shimura, Kazuya. "Broad antiretroviral activity and resistance profile of the novel human immunodeficiency virus integrase inhibitor elvitegravir (JTK-303/GS-9137)." Kyoto University, 2008. http://hdl.handle.net/2433/135828.

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Guéron, David. "Modélisation d'activités et agrégation de profils de vol." Thesis, Aix-Marseille 3, 2011. http://www.theses.fr/2011AIX30044.

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L'agrégation d'activités pour l'identification de catégories de comportements est un enjeu majeur de tous les systèmes socio-techniques complexes actuels. La question clé consiste à réaliser une synthèse de façons de faire (ou praxies) intégrant la variabilité des opérateurs humains impliqués. Dans un cadre aéronautique, l'agrégation d'activités de pilotage vise à accélérer la détermination de procédures améliorant la sécurité des vols et l'efficacité des missions ; elle repose sur les données objectives des paramètres enregistrés des phases de vol significatives et se structure grâce à une in

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Kincer, Caroline D. "A Paleodemographic Analysis of a Sample of Commingled Human Skeletal Remains at Ohio University." Ohio University Honors Tutorial College / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=ouhonors1524843441411637.

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Sugden, Heather. "High resolution palynological, multiple profile and radiocarbon dating studies of early human impacts and environmental change in the Inner Hebrides, Scotland." Thesis, University of Sheffield, 1999. http://etheses.whiterose.ac.uk/10274/.

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The Inner Hebrides comprise a diverse range of environments and vegetation, andarchaeological evidence suggests that people were interacting with these from early Holocene times. There are relatively few detailed palynological investigations from the islands for the early Holocene and not all the published data include quantification of microscopic charcoal which may assist in the interpretation of human impacts. Radiocarbon dates are also lacking from a number of the published profiles so that inter-site comparisons and comparisons with the archaeological record are difficult. Some pollen pro

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Goeiman, Hilary. "Developing a human resource profile for the nutrition workforce in the public health sector in the Western Cape province, South Africa." Thesis, Link to the online version, 2008. http://hdl.handle.net/10019/1750.

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Ogunrombi, Modupe Olufunmilayo. "The effect of grapefruit juice, a P-glycoprotein inhibitor, on organic acid and conjugates urinary profile in healthy human subjects / M.O. Ogunrombi." Thesis, North-West University, 2004. http://hdl.handle.net/10394/411.

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P-glycoprotein (p-gp), a member of the superfamily ATP-binding cassette (ABC) is known to be present in the absorptive enterocytes of the gastro-intestinal tract and many other tissues in the body where it acts mainly as a defence mechanism against exogenous assault. Defects in p-gp is speculated to result in the development of diseases as mutations in genes are causes of numerous diseases in the metabolic mosaic that underlies health. Due to the importance of p-gp, particularly in the intestines, mutation of the gene encoding this protein may lead to the presence of unusual compounds, xenobio

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Carpenter, Melinda. "The expression profile of cytoglobin in human fibrotic lung, and the protective role of cytoglobin in hypoxia and oxidative stress in vitro." Thesis, University of Birmingham, 2010. http://etheses.bham.ac.uk//id/eprint/623/.

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Cytoglobin (CYGB), a novel member of the globin family, has been shown to be upregulated in response to hypoxia, oxidative stress and fibrogenesis. Presented here is evidence of CYGB expression within cells of fibrotic lesions taken from patients with Idiopathic Pulmonary Fibrosis (IPF) and Chronic Obstructive Pulmonary Disease (COPD). CYGB staining was observed in fibroblasts, endothelial cells, type II pneumocytes, type I pneumocytes, haematopoietic stem cells and inflammatory cells, which were identified using cell specific markers. Cell types which express other members of the globin famil

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Castaldo, A. M. "JNK SIGNALLING PATHWAY AND ITS IMPLICATION IN RTT SYNDROME: STUDY ON SYNAPTIC PLASTICITY AND MORPHOLOGICAL PROFILE IN HUMAN AND IN MOUSE MODEL." Doctoral thesis, Università degli Studi di Milano, 2017. http://hdl.handle.net/2434/491878.

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Rett syndrome (RTT) is a rare and progressive neurodevelopmental disorder that occurs in 1:10,000-15,000 females. RTT is characterized by a normal early growth followed by, above all, motor and cognitive regression. RTT is caused by mutations of MECP2 gene, located on X-chromosome and subjected to random inactivation, that generate a very variable phenotype. Methyl-CpG-binding protein-2 (MeCP2) is a transcriptional factor involved in brain connectivity, neural circuits and importantly, in synaptic plasticity and deficits. However, the molecular mechanisms related with these defects are largely

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Botha, Shani. "The cardiovascular profile of HIV–infected South Africans of African descent : a 5–year prospective study / Botha S." Thesis, North-West University, 2011. http://hdl.handle.net/10394/7321.

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With great appreciation, I would like to accentuate the substantial contributions of the following people who made this project possible: To Dr. CMT Fourie (my supervisor), Prof. JM van Rooyen (my co–supervisor) and Prof. AE Schutte (my co–supervisor) whose gracious advise, patient guidance, commitment and support have enabled me to plan, analyse, interpret and write this project in a scientific manner. It has been an educational experience for me, thank you. To Mr. LS Wyldbore for the language editing of this dissertation. I thank all the participants, researchers, field workers and supportin

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Basei, Fernanda Luisa 1983. "Caracterização do perfil de interação da proteína humana Nek4 e sua contextualização funcional = Characterization of the protein interaction profile of the human kinase Nek4 and assignment of its functional context." [s.n.], 2014. http://repositorio.unicamp.br/jspui/handle/REPOSIP/314361.

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Orientador: Jörg Kobarg<br>Tese (doutorado) - Universidade Estadual de Campinas, Instituto de Biologia<br>Made available in DSpace on 2018-08-25T14:15:32Z (GMT). No. of bitstreams: 1 Basei_FernandaLuisa_D.pdf: 43645148 bytes, checksum: 4cb7da11417bc57aea32c2db81dddc18 (MD5) Previous issue date: 2014<br>Resumo: As Neks são proteínas quinases similares a NIMA, proteína que é indispensável para a entrada em mitose de células de Aspergillus nidulans. Em humanos foram identificadas 11 Neks (1-11) e, estudos crescentes vêm demonstrando a participação destas em diversas funções celulares além do co

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Afzal, Mansoor. "Graph-Based Visualization of Ontology-Based Competence Profiles for Research Collaboration." Thesis, Tekniska Högskolan, Högskolan i Jönköping, JTH. Forskningsmiljö Informationsteknik, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-20123.

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Information visualization can be valuable in a wide range of applications, it deals with abstract, non-spatial data and with the representation of data elements in a meaningful form irrespective of the size of the data, because sometimes visualization itself focuses on the certain key aspects of the data in the representation and thus it helps by providing ease for the goal oriented interpretation. Information visualization focuses on providing a spontaneous and deeper level of the understanding of the data. Research collaboration enhances sharing knowledge and also enhances an individual’s ta

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Bonoli, Laura. "Profiling the molecular mechanisms driving the fate of human B cells in response to vaccination." Doctoral thesis, Università degli studi di Padova, 2015. http://hdl.handle.net/11577/3424514.

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Antigen (Ag) encounter activates B cells to proliferate and mature through the formation of germinal centers. Here somatic hypermutation of the variable regions and Immunolgobulin (Ig) isotype switching lead the high affinity Ag-specific clones to two possible differentiation outcomes: antibody (Ab) secreting plasmablasts (PB) or quiescent memory B cells (MBC). The molecular mechanism that drives the fate of a human B cell to differentiate into PB or MBC is poorly understood. Recent studies have provided new insights into the transcriptional program responsible for B cell maturation in mice or

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VOLPE, ELISABETTA. "Gene expression profiling of mycobacterium tuberculosis and human macrophage during host-pathogen interaction." Doctoral thesis, Università degli Studi di Roma "Tor Vergata", 2004. http://hdl.handle.net/2108/208538.

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I macrofagi giocano un ruolo essenziale nella risposta immune a Mycobacterium tuberculosis (Mtb), ma Mtb ha evoluto una serie di meccanismi per superare le risposte macrofagiche e può sopravvivere a lungo all’interno del macrofago umano. Lo studio della risposta trascrizionale all’infezione sia dell’ospite che del patogeno, potrebbe essere interessante per conoscere meglio questa interazione. Con questo scopo noi abbiamo analizzato, a livello trascrizionale, la relazione tra virulento Mtb e macrofago umano dopo 7 giorni di infezione, usando la tecnica del macroarray. Noi abbiamo settato una

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MANCINO, ROBERTA. "Influence of cow diet on nutritional profile of milk and dairy products and effects on alterations of human gut microbiota by an in vitro digestion model." Doctoral thesis, Università di Foggia, 2018. http://hdl.handle.net/11369/363264.

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I consumatori richiedono costantemente la presenza sul mercato di alimenti salutistici, che in termini di latte e prodotti lattiero-caseari si traducono in un latte con percentuali più elevate di acidi grassi “sani” come gli acidi grassi polinsaturi (PUFA), ed una più bassa percentuale di acidi grassi saturi (SFA). Il latte e prodotti lattiero-caseari contribuiscono in modo significativo all’assorbimento di sostanze nutritive essenziali nella dieta. Nonostante ciò, il consumo di latte ha fatto registrare un’inflessione a causa delle linee guida nutrizionali che suggeriscono di limitare il cons

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Danielová, Tereza. "Obrazová analýza mitotických chromosomů." Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2014. http://www.nusl.cz/ntk/nusl-220846.

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This master’s thesis is focused on digital image analysis of mitotic chromosomes. It deals with the design of the processing of digital images - from image preprocessing to clasification of each chromosomes, including testing on a set of images. This work introduces used cytogenetic methods, that are used to visualize chromosomes. In its practical part describes morphology operations and clasification procedure. Classification of the chomosomes was divided into 5 groups (A-G). All algorithms were created in the MATLAB program.

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