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Dissertations / Theses on the topic 'Human proteases'

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Published: 14 March 2023

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1

Lourbakos, Afrodite 1972. "Activation of human protease-activated receptors by proteases from a periodontal pathogen." Monash University, Dept. of Biochemistry and Molecular Biology, 2001. http://arrow.monash.edu.au/hdl/1959.1/8876.

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2

Agrotis, Alexander George. "The regulation of human autophagy by ATG4 proteases." Thesis, University College London (University of London), 2018. http://discovery.ucl.ac.uk/10048926/.

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Autophagy is an important intracellular degradation pathway that delivers cytoplasmic material to lysosomes via double-membrane organelles called autophagosomes. Lipidation of ubiquitin- like LC3/GABARAP proteins on the autophagosome membrane is essential for autophagy. The cysteine protease ATG4 executes C-terminal processing (priming) of newly-synthesised LC3/GABARAP to enable subsequent lipidation. ATG4 is also proposed to be important for deconjugating/delipidating LC3/GABARAP from autophagosome membranes, although the ex- act purpose of this is unclear in mammals. Four ATG4 isoforms (ATG4
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3

Ranjit, Najju. "Characterisation of proteases involved in proteolytic degradation of haemoglobin in the human hookworm Necator americanus." Thesis, Queensland University of Technology, 2008. https://eprints.qut.edu.au/20651/1/Najju_Ranjit_Thesis.pdf.

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With over a billion people infected world wide, hookworms are considered as important human pathogens, particularly in developing countries which have the highest rates of infections. Hookworms reside in the gastrointestinal tract of the host where they continuously feed on blood, leading to conditions such as chronic irondeficiency anaemia. The majority of blood-feeding parasites rely on proteins found in blood to provide many of their nutritional requirements for growth, reproduction and survival. Of the numerous proteins found in blood, haemoglobin (Hb) is one of the most abundant. In order
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4

Ranjit, Najju. "Characterisation of proteases involved in proteolytic degradation of haemoglobin in the human hookworm Necator americanus." Queensland University of Technology, 2008. http://eprints.qut.edu.au/20651/.

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With over a billion people infected world wide, hookworms are considered as important human pathogens, particularly in developing countries which have the highest rates of infections. Hookworms reside in the gastrointestinal tract of the host where they continuously feed on blood, leading to conditions such as chronic irondeficiency anaemia. The majority of blood-feeding parasites rely on proteins found in blood to provide many of their nutritional requirements for growth, reproduction and survival. Of the numerous proteins found in blood, haemoglobin (Hb) is one of the most abundant. In order
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5

Gonzalez, Santana Bibiana. "Cysteine proteases: potential serodiagnostic reagents for human Schistosomiasis and Fasciolosis." Thesis, McGill University, 2012. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=110691.

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Schistosomiasis and fasciolosis are parasitic diseases that affect a great number of people, particularly in developing countries, and cause huge global morbidity. Diagnosis is essential for control, treatment and prognosis of the diseases and yet a simple, cheap, sensitive and specific assay is not readily available for either of them. In the current study, cathepsin B (SmCB) and cathepsin L1 (FhCL1) were investigated as potential diagnostic reagents to detect schistosomiasis and fasciolosis, respectively, in humans. The genes encoding SmCB and FhCL1 were expressed Pichia pastoris and the pro
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6

Riddick, Antony C. P. "Expression profiling of proteases and related genes in human prostate tumours." Thesis, University of East Anglia, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.398820.

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7

Gast, Alain. "Proteases et emphyseme pulmonaire : etude des inhibiteurs de proteases recueillis par lavage bronchoalveolaire." Université Louis Pasteur (Strasbourg) (1971-2008), 1987. http://www.theses.fr/1987STR13070.

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8

Wang, Bingjie. "Novel function of human beta-defensin 2 : protecting epidermal barrier against pathogenic proteases." Thesis, University of Edinburgh, 2017. http://hdl.handle.net/1842/28756.

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Atopic Dermatitis (AD) is a common chronic relapsing inflammatory skin disease affecting 15 - 20% of children and 2 - 10% of adults worldwide, with significant morbidity. A hallmark of AD is disruption of the critical barrier function of upper epidermal layers, causatively linked to environmental stimuli, genetics and infections. Another typical feature of AD is skin infections, especially from Staphylococcus aureus (S. aureus), which closely relates with the disease severity. Although not a normal flora, S. aureus is found on 75-100% of AD lesions (< 30% on healthy skin). S. aureus secrete a
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9

West, Andrew. "Investigations by mass spectrometry of the interactions of novel serine protease inhibitors with herpes simplex virus type 2 and human cytomegalovirus proteases." Thesis, University of Warwick, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.343830.

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10

Mulloy, Rory. "Identification of Transmembrane and Extracellular Host Proteases that Promote Human CoV Entry and Syncytium Formation." Thesis, Université d'Ottawa / University of Ottawa, 2021. http://hdl.handle.net/10393/42673.

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11

LOMBARDI, ANNALIA. "Glucocorticoids and proteases in the pathophysiology of pregnancy and parturition." Doctoral thesis, Università di Siena, 2017. http://hdl.handle.net/11365/1005638.

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Understanding the physiology of pregnancy and parturition enables effective management of pregnancy complications that could otherwise be life threatening for both mother and fetus. A large body of evidence suggests that glucocorticoids (GC) and matrix metalloproteinases (MMPs) play a key role in the pathophysiology of pregnancy and parturition. Glucocorticoids influence several aspects of embryo implantation process including the maternal immune response, embryo attachment and fetal development. Prolonged exposure to high levels of glucocorticoids in pregnancy is dangerous for both placental
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12

Zhu, Huijun. "Involvement of different proteases in the execution and regulation of apoptosis in human monocytic THP.1 cells." Thesis, University of Leicester, 1997. http://hdl.handle.net/2381/30787.

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Ced-3, a cysteine protease, is a key effector of apoptotic cell death in Caenorhabditis elegans. However the role of the Ced-3 mammalian homologues, caspases, and other classes of proteases in apoptosis has not been well understood. This study investigated the involvement of proteases in apoptosis induced by different mechanisms using human monocytic THP.1 cells as a model. Apoptosis, as assessed by morphological and biochemical changes, including nuclear condensation and fragmentation, internucleosomal DNA cleavage and poly-(ADP-ribose) polymerase (PARP) degradation, was induced by cyclohexim
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13

Kennett, Craig Nader. "Comparative histochemical, immunocytochemical and biochemical studies of proteases and their inhibitors in human gingival tissue and crevicular fluid." Thesis, King's College London (University of London), 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.336540.

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14

Vyas, Ishan. "IDENTIFICATION OF PEPTIDASES IN HIGHLY-PATHOGENIC VERSUS WEAKLY-PATHOGENIC NAEGLERIA FOWLERI AMEBAE." VCU Scholars Compass, 2014. http://scholarscompass.vcu.edu/etd/3524.

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Naegleria fowleri, a free-living ameba, is the causative agent of Primary Amebic Meningoencephalitis. Highly-pathogenic mouse-passaged amebae (Mp) and weakly-pathogenic axenically-grown (Ax) N. fowleri were examined for peptidase activity. Zymography and azocasein peptidase activity assays demonstrated that Mp and Ax N. fowleri exhibited a similar peptidase pattern. Prominent for whole cell lysates, membranes and conditioned medium from Mp and Ax amebae were the presence of an activity band of approximately 58kDa and 100 kDa bands susceptible to the action of cysteine and metallopeptidase inhi
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15

Menou, Awen. "Implication des protéases à sérine de la famille des Type II Transmembrane Serine Proteases dans la Fibrose Pulmonaire Idiopathique." Thesis, Sorbonne Paris Cité, 2017. http://www.theses.fr/2017USPCC020/document.

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La Fibrose Pulmonaire Idiopathique (FPI) est une pathologie pulmonaire chronique, progressive, irréversible et mortelle, dont les thérapeutiques sont insuffisantes à ce jour. L'activation de la cascade de la coagulation et des protéases à sérine, délétère dans la progression des maladies pulmonaires chroniques, est une caractéristique de la pathologie. Récemment, un lien a été démontré entre Protease-Activated Receptor-2 (PAR-2), un récepteur cellulaire ubiquitaire, et la progression de la fibrose pulmonaire chez l'homme et la souris. Outre certains facteurs de la coagulation, PAR-2 semble aus
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16

Bayraktar, Eda. "Effects Of Ph On Human Growth Hormone Production By Pichia Pastoris Considering The Expression Levels Of Regulatory Genes." Master's thesis, METU, 2009. http://etd.lib.metu.edu.tr/upload/12610882/index.pdf.

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In this study, the aim was to investigate the effects of pH on therapeutically important protein, recombinant human growth hormone (rhGH), production by Pichia pastoris considering the expression levels of regulatory genes. In this frame, firstly the host microorganism was selected between two different methanol utilization phenotypes of P. pastoris, Mut+ and MutS on media containing glycerol/methanol or sorbitol/methanol. The highest rhGH production, 120 g L-1, and hGH gene expression, 9.84x109 copies mg-1 CDW, were achieved in the medium containing 30 g L-1 sorbitol and 1% (v/v) methanol by
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17

Peterle, Daniele. "Molecular Mechanism in the Alteration of Hemostasis." Doctoral thesis, Università degli studi di Padova, 2018. http://hdl.handle.net/11577/3426350.

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Hemostasis is a finely tuned physiological process that, through the concerted action of several blood cells and proteins, maintains the integrity of the vascular system. This stepwise process begins after a vessel wall injury and includes: an initial vasospasm, a platelet plug formation (primary hemostasis), an assembly and activation of the coagulation factors that results in fibrin deposition at the site of injury (secondary hemostasis), and a final dissolution of the fibrin clot that restores the blood vessel patency (fibrinolysis) (Chapter 1). Alterations affecting one or more of these de
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18

Donnelly, P. K. "Protease and human immunity." Thesis, University of Newcastle Upon Tyne, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.371254.

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19

Sanchez, Eduardo Milton Ramos. "Avaliação do modelo de hamster para detecção das alterações lipídicas e cardiotoxicidade associadas à terapia contra o vírus da imunodeficiência humana." Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/42/42133/tde-25032010-153939/.

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Com a introdução de uma nova classe de antiretrovirais integrantes da terapia anti-retroviral altamente ativa (HAART) para o tratamento das infecções pelo vírus da imunodeficiência humana, começaram a ser descritos inúmeros efeitos secundários.Na tentativa de se estabelecer um modelo animal para o estudo destes efeitos buscou-se uma espécie com similaridade no perfil e metabolismo lipídico. Iniciou-se estudo em Mesocricetus auratus. Foram avaliados o perfil lipídico e glicêmico,função hepática e renal, níveis de auto-anticorpos anti ox-LDL, perfil eletrocardiográfico, alterações histopatológic
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20

Cunha, Joel da. "Estudo da atividade e polimorfismos da Paraoxonase-1 em indivíduos infectados pelo vírus da imunodeficiência humana tipo-1 (HIV-1) tratados com inibidores de protease." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/5/5146/tde-10052013-095130/.

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A enzima Paraoxonase-1 (PON1) possui atividades paraoxonase, arilestearase e lactonase, entre outras. É a mais estuda da família das PONs que é composta pela PON1, PON2 e PON3. Sugere-se, que todas atuam inibindo o processo de peroxidação lipídica de moléculas como a lipoproteína de baixa densidade (LDL) e alta densidade (HDL), caracterizando assim um possível papel anti-aterogênico. O gene da PON1 apresenta dois sítios polimórficos, com a troca de uma Gln192Arg (Q/R) e Met55Leu, que estão associados com diferenças na atividade e concentrações séricas da enzima. Por sua vez, indivíduos soropos
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21

DI, FEDE MARTINA. "Dissecting the role of Neisseria Heparin Binding Antigen cleavage during adaptation of Neisseria meningitidis to mucosal surface." Doctoral thesis, Università di Siena, 2017. http://hdl.handle.net/11365/1009815.

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Neisserial Heparin Binding Antigen (NHBA) is a surface-exposed lipoprotein specific for Neisseria and is one of the three main protein antigens of the Bexsero vaccine. Meningococcal and human proteases, including lactoferrin and kallikrein, cleave NHBA protein upstream or downstream a conserved Arg-rich motif, respectively. The cleavage results in the release of the C-terminal portion of the protein. C-terminal fragment originating from the processing of meningococcal proteases, referred as C2 fragment, exerts a toxic effect on endothelial cells altering their permeability. In this work, we re
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22

Murray, Ewan Hector. "Investigating structure and function relationships in human Stefin A." Thesis, University of Sheffield, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.274964.

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23

Boffito, Marta. "Clinical pharmacology of human immunodeficiency virus-1 protease inhibitors." Thesis, University of Liverpool, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.403237.

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24

Boucaut, Kerry Jane. "Function and regulation of the human serine protease Testisin." Thesis, Queensland University of Technology, 2002.

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25

Fraga, Tatiana Rodrigues. "Identificação de proteases de Leptospira envolvidas com mecanismos de escape do sistema complemento humano." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/42/42133/tde-27112014-094144/.

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A leptospirose é uma zoonose causada por leptospiras patogênicas. Para estabelecer a infecção, estas bactérias desenvolveram estratégias de escape ao sistema complemento. Neste trabalho demonstramos que o sobrenadante de cultura de leptospiras patogênicas é capaz de inibir as três vias do complemento. Observamos que esse sobrenadante possui atividade proteolítica sobre C3, C3b e iC3b, além do FB (via alternativa), C2 e C4b (via clássica e das lectinas). As proteínas C3, C4, C2 e FB também foram clivadas quando soro humano normal (SHN) foi utilizado como fonte de complemento. Demonstramos que a
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26

Fletcher, Jean Margaret. "Proteolytic mechanisms involved in the metastasis of human melanoma cells." Master's thesis, University of Cape Town, 1994. http://hdl.handle.net/11427/27116.

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The metastatic process requires that tumour cells are capable of traversing various micro-environmental barriers, such as the basement membrane. There are various proteolytic mechanisms which could contribute to the process, plasminogen activation by tissue plasminogen activator (tPA) and urokinase plasminogen activator (uPA) is one such mechanism. Extensive reports in the literature (reviewed in the introduction) indicate that most tumour cells synthesize uPA and that it is this enzyme, particularly when receptor-bound, which plays a role in invasion. UCT-Mel 3 is a human malignant melanoma c
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27

Bosnic, Anthony Martin. "Human antibody responses to a chlamydia-secreted protease factor : a thesis /." San Antonio : UTHSC, 2005. http://learningobjects.library.uthscsa.edu/cdm4/item%5Fviewer.php?CISOROOT=/theses&CISOPTR=14&REC=5.

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28

Winston, Alan. "The clinical implications of human immunodeficiency virus-1 protease inhibitor pharmacokinetics." Thesis, Imperial College London, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.444601.

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29

Guðmundsdóttir, Ingibjörg Jóna. "The role of protease-activated receptor-1 in the human vasculature." Thesis, University of Edinburgh, 2010. http://hdl.handle.net/1842/29130.

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Background: Thrombin is a powerful cardiovascular agonist and a vital link between thrombosis and inflammation. In addition to its role in the coagulation cascade, it directly activates platelets, inflammatory cells, endothelium and vascular smooth muscle. Proteaseactivated receptor-1 (PAR-1) has been proposed as the principal thrombin receptor in man although its actions in vivo have not been defined. The aim of this thesis was to determine the direct vascular actions of PAR-1 agonism in the human venous and arterial circulations. Objectives: The effects of PAR-1 activation on dorsal hand vei
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Byrne, Emma Jane. "The activity of human rhinovirus 14 3C protease in artificial polyproteins." Thesis, University of St Andrews, 1999. http://hdl.handle.net/10023/14310.

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HRV14 3C acts as a protease and has a role in RNA replication in vivo, interacting with a cloverleaf structure in picornaviral genomic RNA. Picornaviral 3C proteases are able to cleave both N- and C-terminally producing 3CDpro, or, 3Cpro and 3DPol, respectively. In order to investigate the mechanisms whereby these alternative processing pathways are adopted an artificial polyprotein system was constructed, composed of viral sequences from the P3 region of the viral polyprotein flanked by reporter genes. Two antibiotic resistance genes (KanR, TetR) were cloned to act as reporter genes flanking
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Andersen, Henrik. "Human protease activated receptor 4 and its role in platelet activation /." Thesis, Connect to this title online; UW restricted, 2001. http://hdl.handle.net/1773/9235.

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32

Parry, Christopher Marc. "Molecular identification, characterisation and processing of the Human Herpesvirus-6 Protease." Thesis, London School of Hygiene and Tropical Medicine (University of London), 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.557278.

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33

Silva, Ludmila Bezerra da. "Identificação de proteases de Leptospira envolvidas na degradação de proteínas da matriz extracelular e do plasma humano." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/10/10134/tde-31012018-112506/.

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Leptospiras são bactérias espiroquetas altamente móveis dotadas de estratégias que possibilitam grande eficiência nos processos de invasão e disseminação no hospedeiro. Nosso grupo demonstrou previamente que leptospiras patogênicas secretam proteases capazes de clivar e inativar moléculas-chave do sistema complemento humano, o que confere a essas bactérias a capacidade de driblar os mecanismos de defesa do sistema imune inato. Dada a rápida disseminação das leptospiras durante o processo de infecção, aventou-se a hipótese de que essas proteases secretadas pudessem alvejar uma gama maior de mo
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34

Arispe, Angulo Wara Milenka Trawick Mary Lynn. "Inhibitors of human cathepsin L and cruzain as therapeutic agents." Waco, Tex. : Baylor University, 2008. http://hdl.handle.net/2104/5290.

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Ding, Yan Shirley. "Expression, purification and charaterization of recombinant human T-cell leukemia virus type I protease." Diss., Georgia Institute of Technology, 1998. http://hdl.handle.net/1853/29992.

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36

Ni, Hao II. "Expression of Human Protein C in Transgenic Tobacco." Thesis, Virginia Tech, 1997. http://hdl.handle.net/10919/33367.

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Human Protein C (hPC) is a vitamin K-dependent serine protease that has a critical role in the naturally-occurring anticoagulant pathway. Upon activation of the zymogen by thrombin at the endothelial cell surface, the active form of hPC has anticoagulant activity in hemostasis due to its ability to inactivate factors Va and VIIIa. For biological activity, hPC requires several post-translational modifications including proteolytic cleavage, disulfide bond formation, b-hydroxylation, g-carboxylation, and N-linked glycosylation. Plants have the eukaryotic protein modifying mechanisms required f
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Thomas, James A. "A protease cascade regulates egress of Plasmodium falciparum from the human erythrocyte." Thesis, University College London (University of London), 2018. http://discovery.ucl.ac.uk/10045224/.

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Malaria parasites invade erythrocytes and replicate inside a parasitophorous vacuole (PV). Invasive merozoites eventually egress in a process that involves sequential rupture of first the PV membrane (PVM) then the erythrocyte membrane. Egress is protease-dependent, with both cysteine and serine proteases implicated. The parasite serine protease SUB1 is stored in merozoite secretory organelles that are discharged into the PV 10 minutes before erythrocyte membrane rupture. Pharmacological inhibition of SUB1 activity or discharge blocks egress, but the mechanism by which SUB1 regulates egress is
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38

Martucci, Morena <1983&gt. "Aging in human liver and skeletal muscle: studies on proteasomes." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2014. http://amsdottorato.unibo.it/6292/1/Martucci_Morena_tesi.pdf.

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Aging is a complex phenomenon that affects organs and tissues at a different rate. With advancing age, the skeletal muscle undergoes a progressive loss of mass and strength, a process known as sarcopenia that leads to a decreased mobility and increased risk of falls and invalidity. On the other side, another organ such as the liver that is endowed with a peculiar regenerative capacity seems to be only marginally affected by aging. Accordingly, clinical data indicate that liver transplantation from aged subjects has, in specific conditions, function and duration comparable to those achievable w
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Martucci, Morena <1983&gt. "Aging in human liver and skeletal muscle: studies on proteasomes." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2014. http://amsdottorato.unibo.it/6292/.

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Aging is a complex phenomenon that affects organs and tissues at a different rate. With advancing age, the skeletal muscle undergoes a progressive loss of mass and strength, a process known as sarcopenia that leads to a decreased mobility and increased risk of falls and invalidity. On the other side, another organ such as the liver that is endowed with a peculiar regenerative capacity seems to be only marginally affected by aging. Accordingly, clinical data indicate that liver transplantation from aged subjects has, in specific conditions, function and duration comparable to those achievable w
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Mulley, John Charles. "Genetic marker studies in humans /." Title page, contents and summary only, 1985. http://web4.library.adelaide.edu.au/theses/09PH/09phm958.pdf.

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Amamura, Thaís Akemi. "Clivagem de proteínas do complexo de ataque à membrana do sistema complemento humano por proteases de leptospiras patogênicas." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/42/42133/tde-09032017-134114/.

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A leptospirose é causada por bactérias que pertencem ao gênero Leptospira. Em um estudo realizado por nosso grupo, observou-se que as proteases secretadas por leptospiras patogênicas foram capazes de clivar a molécula C3 do Complemento e seus fragmentos C3b e iC3b, além de Fator B, C4b e C2. Neste trabalho expandimos a análise da atividade proteolítica sobre os componentes do Complexo de Ataque à Membrana (MAC): C6, C7, C8 e C9. Nós observamos que essas proteases clivam todos os componentes do MAC inclusive o complexo solúvel formado e que essas clivagens ocorrem de modo tempo-dependente. Alé
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Maurice, Kelly. "Propriétés biochimiques, enzymatiques et physiologiques de la Human Airway Trypsin-like protease (HAT)." Mémoire, Université de Sherbrooke, 2010. http://savoirs.usherbrooke.ca/handle/11143/4046.

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La fibrose kystique (FK) est caractérisée par une inflammation pulmonaire chronique. Cette dernière est définie entre autres par une augmentation importante de la production de mucus. Celui-ci s'accumule dans les bronches empêchant ainsi l'éventuel passage de l'air. De plus, le mucus forme une barrière protectrice pour les bactéries qui va causer l'inflammation des poumons. La protéase human airway trypsin-like (HAT) a été retrouvée dans les expectorations de patients atteints d'asthme et bronchite chronique, pathologies similaires à la FK. Elle semble jouer un rôle dans l'inflammation car ell
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Paskas, Svetlana. "Expression and function of protease-activated receptors in human monocyte-derived dendritic cells." [S.l. : s.n.], 2006. http://nbn-resolving.de/urn:nbn:de:bsz:289-vts-55899.

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44

Forney, John Russell. "Interaction of the Human Serine Protease Inhibitor Alpha-1-antitrypsin with Cryptosporidium parvum." DigitalCommons@USU, 1997. https://digitalcommons.usu.edu/etd/3961.

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The human serine protease inhibitor (serpin) alpha-1-antitrypsin (AAT) was studied for potential interaction with components of the protozoan parasite Cryptosporidium parvum. A homogenate prepared from C. parvum oocysts was incubated with purified human AAT, and complexes formed between the serpin and components of the homogenate were detected using an enzyme-linked immunosorbent assay (ELISA). Serpin:parasite infections were effectively blocked by preincubating AAT with a cognate target enzyme, porcine pancreatic elastase, prior to performing the ELISA on the homogenate. Incubation of a mixtu
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Reyskens, Kathleen Maria Simone Elise. "The maladaptive effects of HIV protease inhibitors (Lopinavir/Ritonavir) on the rat heart." Stellenbosch : Stellenbosch University, 2013. http://hdl.handle.net/10019.1/85782.

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Thesis (PhD)--Stellenbosch University, 2013.<br>ENGLISH ABSTRACT: Although antiretroviral treatment decreases HIV-AIDS morbidity/mortality, long-term effects include onset of insulin resistance and cardiovascular diseases. Increased oxidative stress and dysregulation of the ubiquitin-proteasome system (UPS) are implicated in protease-inhibitor (PI)-mediated cardio-metabolic pathophysiology. We hypothesized that PI treatment (Lopinavir/Ritonavir) elevates myocardial oxidative stress and concomitantly inhibits the UPS, thereby attenuating cardiac function. Lopinavir/Ritonavir was dissolved in 1%
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46

Tung, Kwok-kwan. "Epigenetic inactivation and tumor suppressive roles of hepatocyte growth factor activator inhibitors(HAIs) in human hepatocellular carcinoma." View the Table of Contents & Abstract, 2007. http://sunzi.lib.hku.hk/hkuto/record/B3971164X.

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47

Fonseca, Iêda Maria Rocha Lima Vieira da. "Avaliação da concentração de proteínas totais na saliva humana frente a diferentes protocolos de tratamento da saliva." reponame:Repositório Institucional da UFC, 2015. http://www.repositorio.ufc.br/handle/riufc/14015.

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FONSECA, Iêda Maria Rocha Lima Vieira da. Avaliação da concentração de proteínas totais na saliva humana frente a diferentes protocolos de tratamento da saliva. 2015. 40 f. Dissertação (Mestrado em Odontologia) - Faculdade de Farmácia, Odontologia e Enfermagem, Universidade Federal do Ceará, Fortaleza, 2015.<br>Submitted by denise santos (denise.santos@ufc.br) on 2015-11-19T12:39:00Z No. of bitstreams: 1 2015_dis_imrlvfonseca.pdf: 763869 bytes, checksum: 7ff734931eddb02f3b4465dc7f77d0f5 (MD5)<br>Approved for entry into archive by denise santos(denise.santos@ufc.br) on 2015-11-19T12:39:41Z (GMT
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48

Richardson, Susanne. "Effect of human kallikreins HK2 and HK3 on the anti-protease system of the cervical mucus of the human female." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape17/PQDD_0018/MQ38181.pdf.

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49

Phenix, Barbara N. "A new role for human immunodeficiency virus (HIV)-1 protease inhibitors: Suppression of apoptosis." Thesis, University of Ottawa (Canada), 2003. http://hdl.handle.net/10393/29000.

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Protease inhibitor (PI)-induced improvements in CD4 T cell counts may be in part independent of PI effects on HIV replication. Since HIV-associated CD4 T cell depletion occurs by apoptosis, we analysed the effect of Pis on apoptosis in peripheral blood lymphocytes (PBLs) from HIV-infected patients and in an uninfected T cell line. The in vivo effects of Pis were monitored in an animal model of stroke and in HIV negative patients taking anti-retroviral therapy (ART) in the context of post-exposure prophylaxis (PEP). Patient PBLs and Jurkat T cells were cultured with Pis. Following stimulation,
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Bredin, Cecilia G. "Studies of cell migration and matrix protease production in human lung cancer cell lines /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7349-969-2/.

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