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Dissertations / Theses on the topic 'Human replacement'

Author: Grafiati

Published: 30 May 2022

Last updated: 31 July 2025

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1

Tkachenko, I. M. "The Prospects for Growing Human Replacement Organs." Thesis, Київський національний університет технологій та дизайну, 2017. https://er.knutd.edu.ua/handle/123456789/8392.

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2

Williams, Paul Eirian. "Aspects of antibody replacement therapy in human immunodeficiency." Thesis, University of Oxford, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.235954.

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3

Underwood, Sarah Anne. "The production of human material for skin replacement." Thesis, University College London (University of London), 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.325362.

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4

McKay, Lindsey (Lindsey Colleen) Carleton University Dissertation Political Economy. "Seeking to cure by replacement: the political economy of organ transplantation." Ottawa, 2001.

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5

Poon, Mei-ying Dora. "Gait analysis of normal and total knee replacement subjects /." Hong Kong : University of Hong Kong, 1997. http://sunzi.lib.hku.hk/hkuto/record.jsp?B18539142.

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6

Hashem, M. H. "Capital replacement modelling with a fixed planning horizon." Thesis, University of Salford, 2001. http://usir.salford.ac.uk/14842/.

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For equipment or plant replacement, when to replace an existing plant, fleet or a part of it, is one of the main concerns in decision-making. The thesis considers this decision-making problem using capital replacement models with a fixed planning horizon, and we took at the behaviour of optimal policy in this context. Application of the models is considered and we compare replacement models with a fixed planning horizon with replacement models with a variable planning horizon models comprising of two cycles. Capital replacement modelling in general and previous work done in the field are revie

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7

Langlotz, Ulrich. "Computer assisted reconstruction and replacement of the human hip joint /." Bern, 2002. http://www.stub.unibe.ch/html/haupt/datenbanken/diss/bestell.html.

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8

Thomas, Rhidian de Winton Melbourne. "Prosthetic replacement of the anterior cruciate ligament of the human knee." Thesis, Queen Mary, University of London, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.286739.

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9

Poon, Mei-ying Dora, and 潘美英. "Gait analysis of normal and total knee replacement subjects." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1997. http://hub.hku.hk/bib/B31214563.

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10

Khaw, Fu-Meng. "Osseointegration of hydroxyapatite coated femoral prostheses : a clinicopathological and biomechanical study of human autopsy retrieved implants." Thesis, University of Newcastle upon Tyne, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.289162.

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11

Fan, Ka Lun. "Characterisation of a human/robot co operative system for total knee replacement surgery." Thesis, Imperial College London, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.272405.

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12

Heller, Kristin Noreen. "Alternative to Gene Replacement for Duchenne Muscular Dystrophy using Human Alpha7 Integrin (ITGA7)." The Ohio State University, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=osu1388401639.

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13

Kinfu, Ashagrea Yohannes. "The quite revolution : an analysis of the change toward below-replacement-level fertility in Addis Ababa." View thesis entry in Australian Digital Theses Program, 2001. http://thesis.anu.edu.au/public/adt-ANU20011218.163822/index.html.

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14

Zhang, Guangyu. "China's far below replacement level fertility : a reality or illusion arising from underreporting of births? /." View thesis entry in Australian Digital Theses Program, 2004. http://thesis.anu.edu.au/public/adt-ANU20050224.092945/index.html.

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15

Welby, Emily. "Isolating and characterising human developing cone photoreceptors towards a cell replacement therapy for retinal dystrophies." Thesis, University College London (University of London), 2017. http://discovery.ucl.ac.uk/1570501/.

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Inherited retinal dystrophies resulting in the death of the light sensitive photoreceptor cells are a major cause of incurable blindness. Loss of the cone photoreceptor cells, which are crucial for colour detection, daylight vision and high visual acuity, has the greatest impact on sight. Retinal differentiation of human pluripotent stem cells (hPSCs) provides a potential renewable source of cone photoreceptors for cell replacement therapy. However many critical challenges remain to be addressed, including i) assessing the similarity between the transcriptomes of bona fide human foetal and in

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16

Schleifenbaum, Stefan, Michael Schmidt, Robert Möbius, et al. "Load and failure behavior of human muscle samples in the context of proximal femur replacement." Universitätsbibliothek Leipzig, 2016. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-204698.

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Background: To ensure adequate function after orthopedic tumor reconstruction, it is important to reattach the remaining soft tissue to the implant. This study aimed at obtaining mechanical properties of textile muscle-implant and muscle-bone connections in a preliminary test. Methods: Two groups of soft-tissue attachment were mechanically tested and compared: Native bone-muscle samples obtained from human femora and muscles attached to a prosthetic implant by means of Trevira® attachment tubes. Additionally, muscle samples were tested with muscle fibers aligned parallel and perpendicular to

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17

Krishnamoorthy, Latha. "The role of macrophages in human wound healing and their response to a tissue engineered dermal replacement in human chronic wounds." Thesis, University of Glasgow, 2006. http://theses.gla.ac.uk/1763/.

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Examining 20 human wound bed biopsies (pilonidal sinus and venous leg ulcers), significant differences were observed between the subpopulations of wound macrophages in acute healing and chronic non-healing wounds. The results exhibit that within the acute wound there is an accumulation of early stage macrophages (mean 20.8, SD 8.6) differentiating from monocytes which become activated and contribute to the wound healing process. There being few early stage macrophages within the chronic wound (mean 10.4, SD 6.7) (p≤0.01). Chronic wounds in comparison demonstrated a significant accumulation of

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18

Liu, Jing. "Regulation of VH replacement in human immature B cells by B cell receptor (BCR)-mediated signaling." Thesis, Birmingham, Ala. : University of Alabama at Birmingham, 2009. https://www.mhsl.uab.edu/dt/2010p/liu.pdf.

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19

Jayaram, H. "Derivation of photoreceptor precursors from human Müller stem cells and their application in experimental photoreceptor replacement." Thesis, University College London (University of London), 2011. http://discovery.ucl.ac.uk/1335834/.

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The adult human retina has a population of Müller glia that exhibit stem cell characteristics. The study investigated the feasibility of obtaining Müller stem cells from small samples of human, rat, rabbit and nonhuman primate retinae in order to provide proof of concept for the development of patient specific therapies. It also explored the role of human Müller stem cells in providing a source of rod photoreceptor precursors that may be applied to experimental photoreceptor replacement. Müller glia with stem cell characteristics were readily obtained from small samples of fresh cadaveric huma

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20

Singhal, Shweta. "Investigation into the application of adult human Müller stem cells in retinal ganglion cell replacement therapy." Thesis, University College London (University of London), 2007. http://discovery.ucl.ac.uk/1445850/.

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This work investigated the potential of adult human Muller stem cells to differentiate towards a retinal ganglion cell (RGC) fate in vitro and their ability to replace damaged RGC in vivo. Muller stem cells isolated from the adult human retina were examined for their expression of RGC developmental markers ATOH7, BRN3B, ISL1 and HUD, and extracellular matrix proteins and growth factors were used to modulate the expression of these RGC makers by these cells in vitro. The role of the Notch signalling pathway in Muller stem cell proliferation and differentiation was also examined and it was found

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21

Sullivan, Camille. "Two's legal but three's a crowd : law, morality and three-parent embryos: regulation of mitochondrial replacement therapy." Thesis, Canberra, ACT : The Australian National University, 2013. http://hdl.handle.net/1885/109247.

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22

Gonzalez, Antonio Jose. "An Analysis of the Effect of Artificial Disc Replacement on the Mechanical Response of the Human Lumbar Spine." NCSU, 2007. http://www.lib.ncsu.edu/theses/available/etd-11062007-154437/.

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The objective of this project is to develop a simplified, two-dimensional mathematical model of the lumbar spine for the purpose of studying the behavior the lumbar spine when affected by degenerative disc disease. Several hypothetical treatment options, including fusion and different types of artificial disc replacements (ADR) were examined. The cases presented consisted of three one-degree of freedom artificial discs, three two-degrees of freedom artificial discs, one ideal three-degrees of freedom artificial disc, a degenerated disc, a fused disc and a healthy spine. The equations of motion

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23

Segalo, L. "Exploring sarcasm as a replacement for corporal punishment in public schools in South Africa." Interim : Interdisciplinary Journal, Vol 13, Issue 4: Central University of Technology Free State Bloemfontein, 2013. http://hdl.handle.net/11462/320.

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Published Articles<br>The dawn of a democratic South Africa in 1994 established a society entrenched in Human Rights milieu. As such, public schools are meant to align their policies with the rule of the law. Particularly, section 10 (1) of South African Schools Act, 84 1996 (hereafter SASA) respectfully prohibits the administration of corporal punishment directed at a learner in public schools. The subsequent section 10 (2) of SASA admonishes that any person contravening section 10 (1) of SASA is liable on conviction to a sentence which could be imposed for assault. These mentioned provisions

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24

Hudson-Shore, Michelle. "The use of non-human primates in biomedical research : addressing the replacement impasse through the social dynamics of science." Thesis, University of Nottingham, 2015. http://eprints.nottingham.ac.uk/30638/.

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Non-human primate experimentation provokes passionate and opposing exchanges, particularly in the UK. This disagreement contributes to an impasse which in turn has prevented the exploration of the important question, if and how primate research could be ended. This project aims to support the examination of this question of impasse presenting data on how it might be overcome by providing a novel and challenging perspective using a multi-method approach, and insights from science and technology studies, to better understand the animal research controversy. The project primarily draws on data fr

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25

Rodriguez, Polo Ignacio [Verfasser], Rüdiger [Akademischer Betreuer] Behr, Rüdiger [Gutachter] Behr, Gregor [Gutachter] Bucher, and Wolfram-Hubertus [Gutachter] Zimmermann. "Non-human primate iPS cells for cell replacement therapies and human cardiovascular disease modeling / Ignacio Rodriguez Polo ; Gutachter: Rüdiger Behr, Gregor Bucher, Wolfram-Hubertus Zimmermann ; Betreuer: Rüdiger Behr." Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2019. http://d-nb.info/1201161096/34.

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26

Milliken, Laura Ann 1970. "Bone mineral density, bone remodeling, insulin-like growth factors, hormone replacement therapy, and exercise training in postmenopausal women." Diss., The University of Arizona, 1998. http://hdl.handle.net/10150/282746.

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Osteoporosis is a condition of reduced bone mineral density (BMD) resulting in an increased susceptibility to bone fractures. The purpose of this study was to determine the effects of 12 months of weight bearing and resistance exercise on BMD, bone formation, measured by serum osteocalcin (OC) and bone resorption, measured by urinary excretion of deoxypyridinoline crosslinks (Dpd), in 2 groups of postmenopausal women who were either taking or not taking hormone replacement therapy (HRT). Secondary aims were to characterize the changes in insulin-like growth factors-l and -2 (IGF-l and -2) and

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27

Belvedere, Claudio <1974&gt. "New functional and biomechanical assessments for the improvement of the surgical navigation systems for joint replacement in the human lower limb." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2009. http://amsdottorato.unibo.it/1499/1/Tesi_Belvedere_Claudio.pdf.

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In case of severe osteoarthritis at the knee causing pain, deformity, and loss of stability and mobility, the clinicians consider that the substitution of these surfaces by means of joint prostheses. The objectives to be pursued by this surgery are: complete pain elimination, restoration of the normal physiological mobility and joint stability, correction of all deformities and, thus, of limping. The knee surgical navigation systems have bee developed in computer-aided surgery in order to improve the surgical final outcome in total knee arthroplasty. These systems provide the surgeon with quan

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Belvedere, Claudio <1974&gt. "New functional and biomechanical assessments for the improvement of the surgical navigation systems for joint replacement in the human lower limb." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2009. http://amsdottorato.unibo.it/1499/.

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In case of severe osteoarthritis at the knee causing pain, deformity, and loss of stability and mobility, the clinicians consider that the substitution of these surfaces by means of joint prostheses. The objectives to be pursued by this surgery are: complete pain elimination, restoration of the normal physiological mobility and joint stability, correction of all deformities and, thus, of limping. The knee surgical navigation systems have bee developed in computer-aided surgery in order to improve the surgical final outcome in total knee arthroplasty. These systems provide the surgeon with quan

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29

Kratzer, James Timothy. "Reengineering a human-like uricase for the treatment of gout." Diss., Georgia Institute of Technology, 2013. http://hdl.handle.net/1853/52149.

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There is an unmet medical need in the treatment of gout. This type of inflammatory arthritis can be efficiently alleviated by the enzyme uricase. This enzyme breaks down uric acid, the causative agent of gout, so it can be flushed from the body. In humans and the other great apes, uricase is a pseudogene and as such is inactive. Research on therapeutic uricases has focused on using enzymes from naturally occurring sources; however, these foreign proteins can be very antigenic and present a potentially life-threatening safety risk to patients. We address the challenges of developing a safer uri

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30

Sidhu, Navdeep Singh. "Crystal Structures of a Bacterial Isocitrate Dehydrogenase and the Human Sulfamidase." Doctoral thesis, Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2014. http://hdl.handle.net/11858/00-1735-0000-0015-A383-5.

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31

Zuo, Heng. "3D Multi-Physics MRI-Based Human Right Ventricle Models for Patients with repaired Tetralogy of Fallot: Cardiac Mechanical Analysis and Surgical Outcome Prediction." Digital WPI, 2017. https://digitalcommons.wpi.edu/etd-dissertations/478.

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Introduction. Computational modelling has been used widely in biological and clinical applications, but relatively less in surgical design and optimization. Magnetic resonance image (MRI)-based right ventricle (RV) models were introduced for patients with repaired Tetralogy of Fallot (rTOF) to assess ventricle cardiac function, and to identify morphological and mechanical parameters which can be used to predict and optimize post-surgery cardiac outcome. Tetralogy of Fallot is a common congenital heart defect which includes a ventricular septal defect and severe right ventricular outflow obst

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32

Yonezawa, Akihito. "Replacement of the V3 region of gp120 with SDF-1 preserves the infectivity of T-cell line-tropic human immunodeficiency virus type 1." Kyoto University, 2002. http://hdl.handle.net/2433/149666.

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33

Zhang, Xia. "Regulation of human apolipoprotein A-I gene expression by estrogenic compounds in cultured hepatoma cell lines, the possible role of equilenin in estrogen replacement therapy." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape7/PQDD_0002/NQ42993.pdf.

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34

Barreiro, Vázquez Antonio. "Development of Pichia pastoris for the production of human α-galactosidase A as a model lysosomal enzyme". Doctoral thesis, Universitat Autònoma de Barcelona, 2016. http://hdl.handle.net/10803/382822.

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L’α-galactosidasa A humana (GLA) pertany a la família d’hidrolases lisosomals involucrades en malalties d’emmagatzemat enzimàtic (MEEs). Les teràpies de reemplaçament enzimàtic (TREs), basades en l’administració de l’enzim disfuncional, són una mesura eficient per alentir l’avanç d’algunes MEEs. Tanmateix, el cost de les TREs disponibles actualment es extremadament elevat. Per tant, es proposa com a solució l’ús de sistemes de producció alternatius. P. pastoris és un sistema prometedor per la producció de productes terapèutic biològics, tot i que el seu patró de glicosilació ha de ser adaptat

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35

Sidhu, Navdeep Singh [Verfasser], George M. [Akademischer Betreuer] Sheldrick, Ralf [Akademischer Betreuer] Ficner, et al. "Crystal Structures of a Bacterial Isocitrate Dehydrogenase and the Human Sulfamidase : Pushing the Limits of Molecular Replacement / Navdeep Singh Sidhu. Gutachter: Ralf Ficner ; Kai Tittmann ; Hartmut Laatsch ; Birger Dittrich ; Francesca Fabbiani. Betreuer: George M. Sheldrick." Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2015. http://d-nb.info/1065445946/34.

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36

M, Olkhovik, and Kononenko A. "Use of artificsal intelligence in the field of civil aviation." Thesis, National Aviation University, 2021. https://er.nau.edu.ua/handle/NAU/53307.

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In the modern world, it is difficult to imagine our lives without the use of Internet technologies and artificial intelligence. We have become accustomed to making life easier and more enjoyable in almost all areas, especially in civil aviation. Іt can be noted that the list of technologies already implemented is quite large and those that are currently being processed are even more extensive. Of course, some of them may not prove their feasibility and effectiveness, but most of them will also improve the services of air carriers and the level of safety.<br>У сучасному світі важко уявити наше

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37

Pennacchi, Paula Comune. "Desenvolvimento de pele humana reconstruída contendo equivalente dérmico glicado na avaliação da eficácia e toxicidade de compostos anti-glicação." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/9/9136/tde-16032016-153203/.

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A glicação não enzimática das proteínas é um fator comum para a fisiopatologia de uma série de transtornos relacionados ao envelhecimento e a doenças como o diabetes mellitus (DM). O geração dos produtos de glicação, os AGEs (do inglês: Advanced Glycation End Products) se dá através de reações de glicação da mariz extracelular (MEC) na derme e têm sido apontado como um dos fatores responsáveis pela perda de elasticidade e deficiência de cicatrização da pele. A permeação cutânea de compostos anti-AGE é uma limitação importante para eficiência terapêutica de compostos que devem atingir camadas m

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38

Mandeville, David Stewart. "The effect of total knee replacement on measures of gait and stair ascent /." view abstract or download file of text, 2006. http://proquest.umi.com/pqdweb?did=1188883681&sid=3&Fmt=2&clientId=11238&RQT=309&VName=PQD.

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Thesis (Ph. D.)--University of Oregon, 2006.<br>Typescript. Includes vita and abstract. Includes bibliographical references (leaves 102-109). Also available for download via the World Wide Web; free to University of Oregon users.

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39

Yoshida, Yuri. "Gait performance for individuals after total knee arthroplasty a longitudinal analysis /." Access to citation, abstract and download form provided by ProQuest Information and Learning Company; downloadable PDF file, 210 p, 2009. http://proquest.umi.com/pqdweb?did=1892057421&sid=6&Fmt=2&clientId=8331&RQT=309&VName=PQD.

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40

Tchokonte-Nana, Venant. "Cellular mechanisms involved in the recapitulation of endocrine development in the duct ligated pancreas." Thesis, Stellenbosch : University of Stellenbosch, 2011. http://hdl.handle.net/10019.1/6828.

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Thesis (PhD)--University of Stellenbosch, 2011.<br>ENGLISH ABSTRACT: Diabetes mellitus is amongst the leading causes of morbidity and mortality in the world, affecting young, adult and old people. Beta cell replacement therapy for insulin delivery remains the ultimate remedy for diabetes. However, insufficient donor pancreas and the use of immunosuppressive drugs prevent the wide-spread of this therapy. Other avenues of self generated beta cells within the organ itself need to be explored. Therefore, understanding the chronobiology of cellular mechanisms in the lineage of beta cell induce

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41

Wefstaedt, Patrick Hans [Verfasser]. "FUNCTIONAL, SIMULATIVE AND IMAGING APPROACHES TO EVALUATE THE OUTCOME AFTER TOTAL HIP REPLACEMENT IN DOGS AND HUMANS / Patrick Hans Wefstaedt." Hannover : Bibliothek der Tierärztlichen Hochschule Hannover, 2012. http://d-nb.info/1031433252/34.

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Wefstaedt, Patrick [Verfasser]. "FUNCTIONAL, SIMULATIVE AND IMAGING APPROACHES TO EVALUATE THE OUTCOME AFTER TOTAL HIP REPLACEMENT IN DOGS AND HUMANS / Patrick Hans Wefstaedt." Hannover : Bibliothek der Tierärztlichen Hochschule Hannover, 2012. http://nbn-resolving.de/urn:nbn:de:gbv:95-h2599.

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43

Carlson, Kjirste Lynn. "Human hip joint mechanics : an investigation into the effects of femoral head endoprosthetic replacements using in vivo and in vitro pressure data." Thesis, Massachusetts Institute of Technology, 1993. http://hdl.handle.net/1721.1/31043.

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44

Sztrymf, Benjamin. "Prise en charge et facteurs pronostiques des épisodes d'insuffisance circulatoire aiguë chez des patients atteints d'Hypertension Artérielle pulmonaire." Phd thesis, Université Paris Sud - Paris XI, 2013. http://tel.archives-ouvertes.fr/tel-00920148.

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L'hypertension artérielle pulmonaire (HTAP) est une maladie caractérisée par une obstruction des artères pulmonaires de petit calibre aboutissant, à terme, à une défaillance cardiaque droite. L'évolution de cette maladie est parfois émaillée d'épisodes de dégradation de l'état fonctionnel des patients, nécessitant une admission en unité de soins intensifs pour surveillance cardioscopique et administration de médicaments inotropes et/ou vasopresseurs. Peu d'éléments permettent à ce jour de guider les praticiens dans la prise en charge de ces patients et la physiopathologie de ces épisodes est a

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Wißing, Christoph Verfasser], та Hervé [Akademischer Betreuer] [Bocherens. "Multi-isotopic tracking (δ13C, δ15N, δ34S) of ancient trophic webs around the time of Neandertal replacement by anatomically modern humans in North-Western Europe / Christoph Wißing ; Betreuer: Hervé Bocherens". Tübingen : Universitätsbibliothek Tübingen, 2016. http://d-nb.info/1164169068/34.

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DAI, ZI-HUANG, and 戴子煌. "Studies on enzyme replacement therapy:coupling of human acid a -glucosidase with human albumin." Thesis, 1987. http://ndltd.ncl.edu.tw/handle/30878902539523210345.

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47

Rodriguez, Polo Ignacio. "Non-human primate iPS cells for cell replacement therapies and human cardiovascular disease modeling." Doctoral thesis, 2019. http://hdl.handle.net/21.11130/00-1735-0000-0005-12BE-1.

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48

Liu, Yi-Cheng, and 劉羿晟. "Biomechanical Investigations of Total Ankle Replacement Prostheses Using a Human Lower Extremity Model." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/ebhb4y.

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碩士<br>國立臺灣科技大學<br>應用科技研究所<br>105<br>Total ankle replacement surgery has been used to treat ankle joint disorders. However, the biomechanical performances of total ankle prostheses were mainly evaluated according to the outcomes of clinical applications. Although the bone-implant constructs developed by the previous studies could provide referable biomechanical outcomes, their numerical models may be oversimplified. Thus, the purpose of this study was to evaluate the biomechanical performances of the ankle joint designs with different ankle postures using finite element methods. Three-dimension

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49

Goldfield, Anna Elizabeth. "The role of physiology and behavior in the replacement of Neanderthals by anatomically modern humans in Europe." Thesis, 2017. https://hdl.handle.net/2144/27078.

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This dissertation comprises three articles that propose explanations for the eventual extinction of Neanderthals in Europe after a period of several thousand years of coexistence with anatomically modern humans (AMH). I propose that bioenergetic differences between Neanderthals and AMH favored the persistence of AMH. This difference in energetic efficiency was augmented by any behavior that was advantageous to AMH. Consequently, such behaviors directly impacted the rate of Neanderthal extinction. The first article proposes a mathematical model that reconstructs Neanderthal and AMH energetic

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Brymer, Rhett. "Professional Human Capital Flows: Temporal Structure of Loss, Replacement and Contingent Bundling Effects on Firm Performance." Thesis, 2012. http://hdl.handle.net/1969.1/ETD-TAMU-2012-08-11886.

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While resource based theory (RBT) addresses the importance of both possessing and orchestrating resources that have the potential of creating competitive advantage, it suggests little about the effects of unintentionally losing such resources. Further, RBT is silent about the manners in which firms replace after such losses by acquiring external resources. Attending to these gaps, this study considers the loss of professional human capital (PHC) in a panel data set of the largest U.S. based law firms, the contingencies of loss that effect subsequent firm performance, and the manner in which fi

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