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Dissertations / Theses on the topic 'Human subjects'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 July 2025

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1

Ken, Stephanie Wong. "Human Subjects." PDXScholar, 2017. https://pdxscholar.library.pdx.edu/open_access_etds/4023.

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Human Subjects is a collection of eight short stories that explore the role of identity, otherness, and personhood in contemporary life. Two sex workers try to buy new faces after a botched plastic surgery, a young girl struggles to find her place in a religious sweat cult, mixed race orphans commune with ghosts in a Korean orphanage, best friends embark on a road trip across America in search of a mother. Human Subjects works to tell stories about deeply felt wants and desires from perspectives at the margins, caught in a state of in between. This collection grapples with what it means to be

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2

Wilder, Eliza C. S. "Human Subjects Testing of Sweat Stimulation Technologies." University of Cincinnati / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1468512004.

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3

Gupta, Jyoti. "Microneedles for transdermal drug delivery in human subjects." Diss., Georgia Institute of Technology, 2009. http://hdl.handle.net/1853/34770.

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Microneedles have been developed as a minimally invasive alternative to painful hypodermic needles to deliver modern biotherapeutics. Previously, several in-vitro and in-vivo animal studies have been conducted to show that microneedles increase skin permeability to a wide range of molecules that cannot cross the skin using conventional transdermal patches due to the skin's stratum corneum barrier. However, only a limited number of studies have been performed to study microneedle-based drug delivery in human subjects. Therefore, the objective of this study was to perform the first-in-humans

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4

Moulden, Drew Jeffrey Andrew. "Physiological mechanisms of task-switching in human subjects." Thesis, University of Ottawa (Canada), 1999. http://hdl.handle.net/10393/8471.

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The nature, and timing, of the cerebral processes that are active when attention is switched between different tasks are not understood. The purpose of this research was to establish electrophysiological evidence for a two-stage, posterior-anterior cerebral processing model for the control of attention switching. Reaction Times (RTs) and Event-Related Potentials (ERPs) were recorded from 22 healthy young adults as attention was cued to switch between two visuomotor tasks. One task ("horizontal") involved determining whether a circle in one of the four boxes of a 2 x 2 grid was in the left or r

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Moulden, Drew J. A. "Physiological mechanisms of task-switching in human subjects." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape10/PQDD_0016/NQ46536.pdf.

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6

Glautier, S. P. "Responses to alcoholic drink cues in human subjects." Thesis, University of Southampton, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.239389.

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7

Safi, Khaled. "Human postural stability analysis : application to Parkinsonian subjects." Thesis, Paris Est, 2016. http://www.theses.fr/2016PESC1066/document.

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L’analyse de la stabilité posturale chez l’homme a fait l’objet, ces dernières années, d’un intérêt grandissant au sein de la communauté scientifique. Le système postural permet de maintenir la stabilité du corps humain en posture statique ou dynamique. Cette capacité à maintenir cette stabilité devient critique dans le cas des sujets Parkinsoniens. La maladie de Parkinson a en effet une forte incidence sur la stabilité posturale. Un moyen efficace pour évaluer l’équilibre postural consiste à analyser les déplacements dans le plan horizontal du centre de pression du corps humain en posture ort

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8

Lane, Eliesh O'Neil. "Decision-making in the human subjects review system." Diss., Available online, Georgia Institute of Technology, 2005, 2005. http://etd.gatech.edu/theses/available/etd-01132005-104405/unrestricted/lane%5Feliesh%5Fo%5F200505%5Fphd.pdf.

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Thesis (Ph. D.)--Public Policy, Georgia Institute of Technology, 2005.<br>Richard P. Barke, Committee Chair ; Roberta Berry, Committee Member ; Ann Bostrom, Committee Member ; Barry Bozeman, Committee Member ; Mary Frank Fox, Committee Member. Vita. Includes bibliographical references.

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9

PLASSMAN, BRENDA LEE. "PERCEPTION OF LUNG VOLUME IN NORMAL HUMAN SUBJECTS." Diss., The University of Arizona, 1986. http://hdl.handle.net/10150/183843.

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Ability to duplicate an inspired volume level was studied in five healthy males using the psychophysical method of reproduction. Three conditions were evaluated in order to investigate the perceptual cues used for obtaining a specific inspired volume. Conditions were designed to progressively remove cues that might affect the subject's ability to duplicate an inspired lung volume. In each, the subject performed a standard inspiration, spanning from end expiratory position to 35% of inspiratory capacity. Conditions were varied as follows: (1) subjects were instructed to perform both the standar

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10

Menz, Hylton Physiology UNSW. "Walking stability in young, old and neuropathic subjects." Awarded by:University of New South Wales. Physiology, 2002. http://handle.unsw.edu.au/1959.4/18637.

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This thesis investigates walking patterns in healthy young people and in people with an increased risk of falling, and determines the physiological contributions to walking stability. First, a review of the relevant literature on techniques for assessing walking stability, age-related changes in balance and gait, and the contributions of vision, vestibular function, peripheral sensation and strength was undertaken. In response to a critical analysis of these findings, a new technique and protocol for the assessment of walking stability was developed. This involved measuring and analysing head

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11

Pitrolo, Yuenan Sun. "fMRI studies of binocular suppression in human amblyopic subjects." Morgantown, W. Va. : [West Virginia University Libraries], 2006. https://eidr.wvu.edu/etd/documentdata.eTD?documentid=4743.

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Thesis (M.S.)--West Virginia University, 2006.<br>Title from document title page. Document formatted into pages; contains vii, 94 p. : ill. (some col.). Includes abstract. Includes bibliographical references (p. 83-94).

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12

Sarrafchi, Amir. "Olfactory sensitivity of human subjects for six predator odorants." Thesis, Linköpings universitet, Institutionen för fysik, kemi och biologi, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-77816.

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The purpose of the present study was to determine olfactory detection thresholds in human subjects for a set of six sulfur-containing odorants which are known to be components of mammalian predator odors. Using a threealternative ascending staircase procedure, the olfactory sensitivity of 12 healthy adult human subjects, 6 males and 6 females was assessed with 2-propylthietane, 2,2-dimethylthietane, 3-mercapto-3-methylbutan-1-ol, 3-mercapto-3- methylbutyl formate, 3-methyl-1-butanethiol, and methyl-2-phenylethyl sulfide. The results showed that A) all six predator odorants were detected at con

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13

Thornton, Jasper Crossley. "The behavioural inhibition system and anxiety in human subjects." Thesis, King's College London (University of London), 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.287456.

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14

Frank, Cynthia A. "Webs of discourse: Caging human subjects as research objects." Diss., The University of Arizona, 2004. http://hdl.handle.net/10150/290028.

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The system of human subjects' protections has recently gone through many changes. Overtly, the structural and functional changes are justified by rhetorical claims of increasing protections for research subjects. Yet, change represents an opportunity for a restructuring of the system in ways not immediately obvious. So, despite rhetorical claims of increased protections for subjects, what problems are delineated and how is the system of human subjects' protections constituted? Examination of the structure and functioning of the system, utilizing a blend of social constructivism, science and te

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15

Ishii, Nobuyuki. "Morphological differences in crano-facial structure between Japanese and Caucasian subjects." Thesis, University College London (University of London), 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.269736.

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16

Robilliard, Donna L. "Clock gene polymorphisms in human subjects with defined circadian phenotypes." Thesis, University of Surrey, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.412045.

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17

Bruce, Mark. "Amino acid metabolism during exercise and recovery in human subjects." Thesis, Loughborough University, 2001. https://dspace.lboro.ac.uk/2134/33569.

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The depletion of muscle and liver glycogen observed during prolonged submaximal exercise is associated with fatigue. Re-synthesis of glycogen stores during the recovery period after exercise is therefore essential for the recovery of endurance exercise capacity. In recent years, attention has focussed on the supplementation of protein in addition to glucose-polymer during recovery from exercise in an attempt to further increase glycogen synthesis. The aims of the first and second studies in this thesis were to investigate the effect of glucose-polymer and amino acid ingestion, and solely amino

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18

Poon, Mei-ying Dora. "Gait analysis of normal and total knee replacement subjects /." Hong Kong : University of Hong Kong, 1997. http://sunzi.lib.hku.hk/hkuto/record.jsp?B18539142.

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Poon, Mei-ying Dora, and 潘美英. "Gait analysis of normal and total knee replacement subjects." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1997. http://hub.hku.hk/bib/B31214563.

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20

Fordy, Graham Robert. "The Physiological Consequences of Breathing Supplementary Oxygen in Healthy Human Subjects." Thesis, University of Birmingham, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.487508.

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Previous studies have implicated oxygen (02)-dependent substances in the vasodilator response to muscle contraction. This thesis explores the effect of breathing supplementary O2, (40% O2: hyperoxia) on the increase in forearm blood flow (FBF) and vascular conductance (functional hyperaemia) evoked by forearm contractions in healthy young male subjects. Hyperoxia given throughout the protocol did not affect resting vascular conductance, yet reduced the hyperaemia evoked by sub-maximal static and rhythmic contractions and by maximal voluntary effort contractions (100% MVE). Hyperoxia given only

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21

Chen, Yin. "A study of cartenoids uptake in human subjects and their metabolites." FIU Digital Commons, 1999. http://digitalcommons.fiu.edu/etd/2148.

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In this study, a metabolite of lutein was tentatively shown to result from oxidation of lutein by performing a reduction reaction. The result is important evidence that supports the hypothesis that lutein functions as an antioxidant in the human body. In a long term of dietary supplementary study of zeaxanthin in a human subject, the expected increase in the serum concentration of the supplement was accompanied by an increase in serum concentration of several metabolites. A six-month low dose dietary supplementation with lutein in 2 2 human subjects was performed with an expected result in inc

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22

Jiang, Ruiwei. "Genome-wide analysis of DNA methylation variance in healthy human subjects." Thesis, University of British Columbia, 2015. http://hdl.handle.net/2429/52977.

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DNA methylation is a type of epigenetic modification that modulates gene expression by acting as an intermediate between genes and environment; this in turn could trigger phenotypic changes with widespread implications in both disease and population models. Unlike DNA sequence, which is relatively stable and finite, DNA methylation presents itself differently in different tissues, and it is described as the sum of interactions affecting attachment of methyl groups to DNA mostly as a result of development and aging, with minor influences from stochastic variability, and environmental factors. M

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23

Chan, Shin Yee. "Biomarkers of tea and coffee-derived polyphenol exposure in human subjects." University of Western Australia. School of Medicine and Pharmacology, 2004. http://theses.library.uwa.edu.au/adt-WU2004.0046.

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Tea and coffee are rich in polyphenols with a variety of biological activities. Polyphenols found in tea are predominantly flavonoids, of which up to 15% are present as free or esterified gallic acid. Coffee polyphenols are almost wholly comprised of chlorogenic acids. Many of the demonstrated activities of polyphenols are consistent with favourable effects on the risk of chronic diseases. In investigating the relationships between intake and exposure to such compounds and chronic disease-related endpoints, it is important to be able to identify biomarkers that are specific to the compounds of

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24

Paisley, K. E. "Vascular function in human subjects with nephrotic syndrome and asymptomatic proteinuria." Thesis, University of Oxford, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.427636.

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25

Thamrin, Husni. "Modelling the respiratory control system in human subjects for excercise conditions." Thesis, University of Glasgow, 2008. http://theses.gla.ac.uk/421/.

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A model is a very helpful tool to describe, interpret and explain the behaviour of a highly complex system such as the human respiratory system. The research work presented in this thesis is concerned with the development of a nonlinear dynamic simulation model of the respiratory control system in human subjects for exercise conditions. Modelling the respiratory system is not a new activity but the development of a general model that takes into account the conditions above the lactate threshold has not been attempted previously because of a number of problems that arise for these particular op

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26

Lynn, Eleanor Jane Elizabeth. "Investigations into the antioxidant effects of soya isoflavones in human subjects." Thesis, King's College London (University of London), 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.413485.

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27

Viguier, Thomas 1978. "Evaluating visualization in formal requirements specification : an experiment with human subjects." Thesis, Massachusetts Institute of Technology, 2003. http://hdl.handle.net/1721.1/82784.

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28

Kumar, Arun. "Studies of Saccade and Vergence Eye Movement Interactions in Human Subjects." Case Western Reserve University School of Graduate Studies / OhioLINK, 2005. http://rave.ohiolink.edu/etdc/view?acc_num=case1105936593.

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29

Heath, Jacob. "Biometric Classification of Human Subjects Using Electroencephalography Auditory Event-Related Potentials." University of Cincinnati / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1439300974.

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30

Aziz, Miriam. "The regulation of medical research involving human subjects : a comparative study." Thesis, University of Edinburgh, 1998. http://hdl.handle.net/1842/21357.

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This thesis is concerned with finding an appropriate legal response to medical research involving human subjects. The first section contains Chapter One which consists of an historical account of forms of unethical research and asks two questions; first, how could such things have been done in the name of research? Secondly, how could society allow them to take place? How were the safeguards overridden? What was the environment or climate within which unethical research was allowed to flourish? The history of the regulation of medical research testifies to the social climate within which resea

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31

Agrawal, Kalpana Rajesh. "The effects of food texture on chewing patterns in human subjects." Thesis, Hong Kong : University of Hong Kong, 1999. http://sunzi.lib.hku.hk/hkuto/record.jsp?B20565719.

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32

Leavitt, Michael G. "mTOR Pathway Activation Following Resistance Exercise with Vibration in Human Subjects." BYU ScholarsArchive, 2013. https://scholarsarchive.byu.edu/etd/3772.

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Functional adaptations in human skeletal muscle following a period of resistance exercise are the result of regular activation of cellular signaling pathways that elevate muscle protein synthesis. It has been reported that the addition of whole body vibration (WBV) to a resistance exercise program enhances performance. Such improvements in muscle function may be the result of increased activation of cellular signaling pathways associated with muscle growth. Purpose: We have investigated whether an acute bout of resistance exercise in combination with WBV results in a greater activation of the

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33

Jiang, Yu. "Population pharmacokinetics of ethanol and delta-9 tetrahydrocannabinol in human subjects." Diss., University of Iowa, 2017. https://ir.uiowa.edu/etd/5783.

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The pharmacokinetics of ethanol and (-)-trans-isomer of 9-tetrahydrocannabinol (THC), and the pharmacokinetic interaction between them were characterized using statistical models in this thesis. In chapter II, a semi-mechanistic absorption rate dependent hepatic extraction model was developed to characterize ethanol pharmacokinetics. The statistical analysis conducted based on this model indicated no association between ethanol disposition and subject age or sex, and a 23% higher typical Vmax value, a 12.5% lower typical Km value for heavy drinkers compared with moderate drinkers. In chapter I

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34

Amevor, Solomon Francis. "Renal physiology and aluminum biokinetics : studies in laboratory rats and human subjects /." [S.l.] : [s.n.], 1995. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=10972.

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35

Bengtsson, Therése. "Eye preference in human subjects : Consistency across measures and correlation with handedness." Thesis, Linköping University, Linköping University, Department of Physics, Chemistry and Biology, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-57683.

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<p>The aim of the present study was to determine the distributions of and correlations between hand preference, visual acuity and eye preference through a series of tests in 50 males 50 females aged between 17 and 39 years. Handedness was determined through the Edinburgh handedness inventory questionnaire. The handedness distribution was: right-handed 90%, left-handed 1 %, and ambidextrous 9%. I found that 30 % had better visual acuity with their right eye, 39 % had better visual acuity with their left eye, and 31% had the same visual acuity with both eyes. 75.2% on average use

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36

Menely, Tobias. "Cultivated sympathies human sentiments and animal subjects in the long eighteenth century /." [Bloomington, Ind.] : Indiana University, 2006. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3215203.

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Thesis (Ph.D.)--Indiana University, Dept. of English, 2006.<br>Source: Dissertation Abstracts International, Volume: 67-04, Section: A, page: 1351. Advisers: Deidre Lynch; Nick Williams. "Title from dissertation home page (viewed June 18, 2007)."

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37

Lind, Britta. "Evaluation of isovolumic myocardial motions in human subjects using tissue velocity echocardiography /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-651-4/.

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38

Jacobs, David. "The dextroamphetamine response in human subjects : a psychological, psychophysiological and neuroendocrine study /." Title page, table of contents and summary only, 1985. http://web4.library.adelaide.edu.au/theses/09MD/09mdj17.pdf.

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39

Shaw, Christine. "Temporal memory in human amnesic subjects and rats with specific brain lesions." Thesis, Durham University, 1992. http://etheses.dur.ac.uk/5755/.

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Temporal processing was assessed in a group of alcoholic Korsakoff subjects, post viral encephalitic subjects, alcoholic control and normal control subjects. Subjects were tested on their ability to reproduce and estimate intervals of time ranging from 3 to 96 seconds. Also, a computerised analogue of the fixed interval procedure used with animals was designed and used to test subjects' estimations of intervals of 15 and 30 seconds. Memory for temporal order was also assessed using an object recency task which also incorporated a recognition memory test. It was found that Korsakoff subjects we

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40

Kelly, Ann Horton. "Evidence-based medicine and pragmatic populations : fact-making in human subjects research." Thesis, University of Cambridge, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.612720.

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41

Turner, Rhiannon Rosalind. "Genetic and functional analysis of endothelial nitric oxide synthase in human subjects." Thesis, University of Cambridge, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.620624.

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42

Jayapaul, Muthu Kumaran. "Metabolic abnormalities in human subjects with variation in the Calpain 10 gene." Thesis, University of Newcastle upon Tyne, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.489334.

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43

Vandamme, Céline. "Characterisation of AAV capsid-specific CD8+ T cell responses in human subjects." Thesis, Nantes, 2016. http://www.theses.fr/2016NANT1014/document.

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L’immunité pré-existante dirigée contre la capside de l’AAV constitue l’un des obstacles majeurs à la sécurité et à l’efficacité du transfert de gène à l’aide de vecteurs AAVr. En particulier, les réponses cellulaires cytotoxiques dirigées contre l’AAV se sont trouvées être un défi à caractériser en raison de la faible fréquence des LT CD8+ circulants spécifiques de la capside, qui peuvent rarement être détectés par cytométrie de flux ou test ELISpot classiques. Ici, nous avons utilisé des tétramères de CMH classe I fluorescents en association avec un enrichissement magnétique pour détecter ex

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44

Ceko, Marta. "The role of insula in somatosensory plasticity: MRI studies in human subjects." Thesis, McGill University, 2013. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=119591.

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The insula is an important cortical processing area for thin fiber somatosensory input, including nociceptive and thermal input. This thesis desribes a series of studies focusing on the human insular cortex, in which structural and functional MRI, together with psychophysical testing, were used to explore the relationship between brain changes and alterations in somatosensory processing and regulation. In Study 1, we reported insular gray matter (GM) changes in a unique patient lacking large-fiber somatosensory input (proprioception, discriminative touch), but with intact thin-fiber input proj

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45

Margaretten, Nadine C. "Effects of Antiepileptic Drugs on Immune Function in Human Subjects and Mice." DigitalCommons@USU, 1985. https://digitalcommons.usu.edu/etd/4639.

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A number of immune abnormalities have been found in epileptic patients treated with antiepileptic drugs (AED). The alterations seen range from mild suppression of immunoglobulins to severly impaired humoral and cellular immunities. There is evidence for both drug effects and genetic or acquired factors as contributors to these abnormalities. In order to examine the basis for immune abnormalities in patients with epilepsy, a number of experimental designs were employed: clinical studies, in vitro studies, and use of an animal model. Peripheral blood mononuclear cells (PBMC) isolated from epilep

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46

Hilts, Wade William. "Emulating Balance Control Observed in Human Test Subjects with a Neural Network." PDXScholar, 2018. https://pdxscholar.library.pdx.edu/open_access_etds/4499.

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Human balance control is a complex feedback system that must be adaptable and robust in an infinitely varying external environment. It is probable that there are many concurrent control loops occurring in the central nervous system that achieve stability for a variety of postural perturbations. Though many engineering models of human balance control have been tested, no models of how these controllers might operate within the nervous system have yet been developed. We have focused on building a model of a proprioceptive feedback loop with simulated neurons. The proprioceptive referenced portio

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47

Bracken, Matthew. "Relative Phase Analysis of Lower Extremity Kinematics Among Subjects with Chronic Ankle Instability." Connect to full text in OhioLINK ETD Center, 2009. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=toledo1241209584.

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Thesis (M.S.)--University of Toledo, 2009.<br>Typescript. "Submitted as partial fulfillment of the requirements for The Masters of Science degree in Exercise Science." "A thesis entitled"--at head of title. Bibliography: leaves 66-67.

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48

Roach, John O. "Beliefs about racial differences : a converging methods, with subjects approach." Thesis, Georgia Institute of Technology, 1995. http://hdl.handle.net/1853/30948.

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49

Shafi, Heather Selsor Stephen R. "Social modulation of pain in human subjects effects of empathy on pain perception /." Diss., Connect to the thesis, 2007. http://hdl.handle.net/10066/1058.

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50

Black, Alison J. "Investigation of the influence of parathyroid hormone on bone metabolism in human subjects." Thesis, University of Aberdeen, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.440594.

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The aim of my thesis was to investigate the influence of PTH on bone metabolism in women at the menopause and in pregnancy. Firstly I examined the influence of PTH in early postmenopausal women. My results show that different PTH concentrations have significant effects on bone turnover but these are small in comparison to those of oestrogen. A clear seasonality was seen for PTH. The other major finding was that the highest quartile of Amino Terminal Propeptide of Type 1 Collagen (PINP) concentration predicted future fracture. Next I investigated the increased fracture risk in pregnancy. Parat

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