Log in

Relevant bibliographies by topics / Human Umbilical Cord Matrix-Derived Mesenchymal Cells / Journal articles

To see the other types of publications on this topic, follow the link: Human Umbilical Cord Matrix-Derived Mesenchymal Cells.

Journal articles on the topic 'Human Umbilical Cord Matrix-Derived Mesenchymal Cells'

Author: Grafiati

Published: 3 June 2025

Last updated: 19 July 2025

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 journal articles for your research on the topic 'Human Umbilical Cord Matrix-Derived Mesenchymal Cells.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.

1

Dhitiseith, D., and S. Honsawek. "Differential Expression of Osteogenic Differentiation in Human Umbilical Cord Wharton’s Jelly-Derived Mesenchymal Stem Cells Treated with Demineralized Bone." Advanced Materials Research 55-57 (August 2008): 697–700. http://dx.doi.org/10.4028/www.scientific.net/amr.55-57.697.

Full text

Abstract:

Mesenchymal stem cells are multipotential cells capable of differentiating into osteoblasts, chondrocytes, adipocytes, tenocytes, and myoblasts. Wharton’s jelly consists of stem cells that are a rich source of primitive multipotent mesenchymal cells. Demineralized bone matrix (DBM) has been widely utilized as a biomaterial to promote new bone formation. We isolate and characterize umbilical cord Wharton’s Jelly-derived mesenchymal stem (UCMS) cells derived from Wharton’s jelly and examine the biological activity of DBM in this cell line. Osteoblast differentiation of the UCMS cells was determi

APA, Harvard, Vancouver, ISO, and other styles

2

Kacham, Santhosh, Tejal Sunil Bhure, Sindhuja D. Eswaramoorthy, et al. "Human Umbilical Cord-Derived Mesenchymal Stem Cells Promote Corneal Epithelial Repair In Vitro." Cells 10, no. 5 (2021): 1254. http://dx.doi.org/10.3390/cells10051254.

Full text

Abstract:

Corneal injuries are among the leading causes of blindness and vision impairment. Trauma, infectious keratitis, thermal and chemical (acids and alkali burn) injuries may lead to irreversible corneal scarring, neovascularization, conjunctivalization, and limbal stem cell deficiency. Bilateral blindness constitutes 12% of total global blindness and corneal transplantation remains a stand-alone treatment modality for the majority of end-stage corneal diseases. However, global shortage of donor corneas, the potential risk of graft rejection, and severe side effects arising from long-term use of im

APA, Harvard, Vancouver, ISO, and other styles

3

Lv, Hong Wei, Yin Zhang, Mei Yu Sun, et al. "Matrix Elasticity Affects Integrin Expression in Human Umbilical Cord-Derived Mesenchymal Stem Cells." Materials Science Forum 815 (March 2015): 412–23. http://dx.doi.org/10.4028/www.scientific.net/msf.815.412.

Full text

Abstract:

Mesenchymal stem cells (MSCs) are a powerful cellular alternative for regenerative medicine and tissue engineering applications due to their multipotency. It is becoming increasingly clear that elasticity of extracellular matrix (ECM) has a profound effect on cell phenotype including adhesion, proliferation and differentiation. Integrins are considered to be important mechanoreceptors in mechanotransduction. While numerous studies have focused on α2, β1 and β3 integrin involvement in substrate stiffness-driven commitment of bone marrow MSCs, comparatively little is known about the change of α5

APA, Harvard, Vancouver, ISO, and other styles

4

Lombardo, Marta Tiffany, Martina Gabrielli, Florence Julien-Marsollier, et al. "Human Umbilical Cord-Mesenchymal Stem Cells Promote Extracellular Matrix Remodeling in Microglia." Cells 13, no. 19 (2024): 1665. http://dx.doi.org/10.3390/cells13191665.

Full text

Abstract:

Human mesenchymal stem cells modulate the immune response and are good candidates for cell therapy in neuroinflammatory brain disorders affecting both adult and premature infants. Recent evidence indicates that through their secretome, mesenchymal stem cells direct microglia, brain-resident immune cells, toward pro-regenerative functions, but the mechanisms underlying microglial phenotypic transition are still under investigation. Using an in vitro coculture approach combined with transcriptomic analysis, we identified the extracellular matrix as the most relevant pathway altered by the human

APA, Harvard, Vancouver, ISO, and other styles

5

Harahap, Dianita Halimah, and Gampo Alam Irdam. "Human umbilical cords mesenchymal stem cells for kidney diseases." Bali Medical Journal 11, no. 1 (2022): 155–59. http://dx.doi.org/10.15562/bmj.v11i1.3085.

Full text

Abstract:

Stem cell therapy is an emerging therapy in the medical field. Recent studies show that stem cell therapy gives promising results. One of the stem cell sources is the human umbilical cord that has many potential, not only for therapy alone but also for banking. Human umbilical cord mesenchymal stem cells (HUCMSCs) have greater advantages than bone marrow and adipose tissue-derived stem cells in isolating the cells and the shortest culture period. Studies on animal models showed improvement of kidney disease in the various mechanism. Human studies regarding human umbilical cord mesenchymal stem

APA, Harvard, Vancouver, ISO, and other styles

6

Pham, Liem Hieu, Ngoc Bich Vu, and Phuc Van Pham. "The subpopulation of CD105 negative mesenchymal stem cells show strong immunomodulation capacity compared to CD105 positive mesenchymal stem cells." Biomedical Research and Therapy 6, no. 4 (2019): 3131–40. http://dx.doi.org/10.15419/bmrat.v6i4.538.

Full text

Abstract:

Introduction: Human mesenchymal stem cells (MSCs) are the most popular stem cells applied in disease treatment. MSCs can be isolated and in vitro expanded from various sources such as bone marrow, peripheral blood, umbilical cord blood, umbilical cord tissue, and adipose tissue. According to Dominici et al. (2006), MSCs should express CD105, an essential marker used to confirm MSCs. However, some recent studies have show that MSCs contained a subpopulation that is negative for CD105. This study aimed to compare the immune modulation capacity of 2 populations of CD105 positive (CD105+) and nega

APA, Harvard, Vancouver, ISO, and other styles

7

Varkouhi, Amir K., Mirjana Jerkic, Lindsay Ormesher та ін. "Extracellular Vesicles from Interferon-γ–primed Human Umbilical Cord Mesenchymal Stromal Cells Reduce Escherichia coli–induced Acute Lung Injury in Rats". Anesthesiology 130, № 5 (2019): 778–90. http://dx.doi.org/10.1097/aln.0000000000002655.

Full text

Abstract:

Abstract Editor’s Perspective What We Already Know about This Topic What This Article Tells Us That Is New Background Human umbilical cord mesenchymal stromal cells possess considerable therapeutic promise for acute respiratory distress syndrome. Umbilical cord mesenchymal stromal cells may exert therapeutic effects via extracellular vesicles, while priming umbilical cord mesenchymal stromal cells may further enhance their effect. The authors investigated whether interferon-γ–primed umbilical cord mesenchymal stromal cells would generate mesenchymal stromal cell–derived extracellular vesicles

APA, Harvard, Vancouver, ISO, and other styles

8

Salehinejad, Parvin, Noorjahan Banu Alitheen, Abdul Manaf Ali, et al. "Neural differentiation of human umbilical cord matrix-derived mesenchymal cells under special culture conditions." Cytotechnology 67, no. 3 (2014): 449–60. http://dx.doi.org/10.1007/s10616-014-9703-6.

Full text

APA, Harvard, Vancouver, ISO, and other styles

9

Latifpour, Mostafa, Seyed Noureddin Nematollahi-Mahani, Massoud Deilamy, et al. "Improvement in Cardiac Function following Transplantation of Human Umbilical Cord Matrix-Derived Mesenchymal Cells." Cardiology 120, no. 1 (2011): 9–18. http://dx.doi.org/10.1159/000332581.

Full text

APA, Harvard, Vancouver, ISO, and other styles

10

Arutyunyan, Irina, Andrey Elchaninov, Andrey Makarov, and Timur Fatkhudinov. "Umbilical Cord as Prospective Source for Mesenchymal Stem Cell-Based Therapy." Stem Cells International 2016 (2016): 1–17. http://dx.doi.org/10.1155/2016/6901286.

Full text

Abstract:

The paper presents current evidence on the properties of human umbilical cord-derived mesenchymal stem cells, including origin, proliferative potential, plasticity, stability of karyotype and phenotype, transcriptome, secretome, and immunomodulatory activity. A review of preclinical studies and clinical trials using this cell type is performed. Prospects for the use of mesenchymal stem cells, derived from the umbilical cord, in cell transplantation are associated with the need for specialized biobanking and transplant standardization criteria.

APA, Harvard, Vancouver, ISO, and other styles

11

Qi, Kai. "Immunoregulatory properties of human umbilical cord derived mesenchymal stem cells." Cytotherapy 17, no. 6 (2015): S47. http://dx.doi.org/10.1016/j.jcyt.2015.03.472.

Full text

APA, Harvard, Vancouver, ISO, and other styles

12

Stefańska, Katarzyna, Katarzyna Ożegowska, Greg Hutchings, et al. "Human Wharton’s Jelly—Cellular Specificity, Stemness Potency, Animal Models, and Current Application in Human Clinical Trials." Journal of Clinical Medicine 9, no. 4 (2020): 1102. http://dx.doi.org/10.3390/jcm9041102.

Full text

Abstract:

Stem cell therapies offer a great promise for regenerative and reconstructive medicine, due to their self-renewal and differentiation capacity. Although embryonic stem cells are pluripotent, their utilization involves embryo destruction and is ethically controversial. Therefore, adult tissues that have emerged as an alternative source of stem cells and perinatal tissues, such as the umbilical cord, appear to be particularly attractive. Wharton’s jelly, a gelatinous connective tissue contained in the umbilical cord, is abundant in mesenchymal stem cells (MSCs) that express CD105, CD73, CD90, Oc

APA, Harvard, Vancouver, ISO, and other styles

13

Baba, Kyoko, Yasuharu Yamazaki, Shigehiro Ikemoto, Kazuya Aoyagi, Akira Takeda, and Eiju Uchinuma. "Osteogenic potential of human umbilical cord-derived mesenchymal stromal cells cultured with umbilical cord blood-derived autoserum." Journal of Cranio-Maxillofacial Surgery 40, no. 8 (2012): 768–72. http://dx.doi.org/10.1016/j.jcms.2012.02.006.

Full text

APA, Harvard, Vancouver, ISO, and other styles

14

Day, A. G. E., W. R. Francis, K. Fu, I. L. Pieper, O. Guy, and Z. Xia. "Osteogenic Potential of Human Umbilical Cord Mesenchymal Stem Cells on Coralline Hydroxyapatite/Calcium Carbonate Microparticles." Stem Cells International 2018 (September 5, 2018): 1–9. http://dx.doi.org/10.1155/2018/4258613.

Full text

Abstract:

Coralline hydroxyapatite/calcium carbonate (CHACC) is a biodegradable and osteoconductive bone graft material with promising clinical performance. CHACC has been shown to support proliferation and osteogenic differentiation of human bone marrow mesenchymal stem cells (MSCs)in vitroand demonstrated to work as a functional scaffold for bone formationin vivo.Umbilical cord matrix is a more accessible and abundant tissue source of MSCs, but its osteogenic capacity in comparison to human bone marrow when cultured on CHACC has not yet been demonstrated. In this study, we assessed the osteogenic diff

APA, Harvard, Vancouver, ISO, and other styles

15

Salehinejad, Parvin, Noorjahan Banu Alitheen, Seyed Noureddin Nematollahi-Mahani, et al. "Effect of culture media on expansion properties of human umbilical cord matrix-derived mesenchymal cells." Cytotherapy 14, no. 8 (2012): 948–53. http://dx.doi.org/10.3109/14653249.2012.684377.

Full text

APA, Harvard, Vancouver, ISO, and other styles

16

Kadam, Sachin S., and Ramesh R. Bhonde. "Islet neogenesis from the constitutively nestin expressing human umbilical cord matrix derived mesenchymal stem cells." Islets 2, no. 2 (2010): 112–20. http://dx.doi.org/10.4161/isl.2.2.11280.

Full text

APA, Harvard, Vancouver, ISO, and other styles

17

Stefańska, Katarzyna, Rut Bryl, Greg Hutchings, Jamil A. Shibli, and Marta Dyszkiewicz-Konwińska. "Human umbilical cord stem cells – the discovery, history and possible application." Medical Journal of Cell Biology 8, no. 2 (2020): 78–82. http://dx.doi.org/10.2478/acb-2020-0009.

Full text

Abstract:

AbstractStem cells are now one of the most extensively studied fields in experimental medicine. Although embryonic stem cells (ESCs) have the capability to differentiate into lineages derived from all three primary germ layers, their use remains ethically controversial. Mesenchymal stromal cells’ (MSCs) utilization is not burdened with such concerns. MSCs were primarily characterized as fibroblastic cells from bone marrow stroma, with the ability to adhere to plastic and form clonogenic colonies (CFU-Fs – colony-forming unit-fibroblasts). Subsequent studies led to their isolation from various

APA, Harvard, Vancouver, ISO, and other styles

18

Friedman, Robb, Monica Betancur, Hande Tuncer, Laurent Boissel, Curtis Cetrulo, and Hans-Georg Klingemann. "Co-Transplantation of Autologous Umbilical Cord Matrix Mesenchymal Stem Cells Improves Engraftment of Umbilical Cord Blood in NOD/SCID Mice." Blood 108, no. 11 (2006): 2569. http://dx.doi.org/10.1182/blood.v108.11.2569.2569.

Full text

Abstract:

Abstract Umbilical cord blood (UCB) is a viable source of hematopoietic stem cells for transplantation of children and adults undergoing treatment for hematological malignancies. However only 4% of adults 70kg and over have a UCB unit available which contains the widely accepted minimum cell dose of 1.5x107 mononuclear cells per kilogram. Co-transplantation of hematopoietic stem cells with mesenchymal stem cells may enhance engraftment and therefore decrease transplant-related morbidity and mortality from delayed leukocyte recovery associated with a low pre-transplant cell dose. Umbilical cord

APA, Harvard, Vancouver, ISO, and other styles

19

CAO, Fu-jiang, and Shi-qing FENG. "Human umbilical cord mesenchymal stem cells and the treatment of spinal cord injury." Chinese Medical Journal 122, no. 2 (2009): 225–31. http://dx.doi.org/10.3760/cma.j.issn.0366-6999.2009.02.021.

Full text

Abstract:

Objective To review the recent studies about human umbilical cord mesenchymal stem cells (hUCMSCs) and advances in the treatment of spinal cord injury. Data sources Published articles (1983-2007) about hUCMSCs and spinal cord injury were selected using Medline. Study selection Articles selected were relevant to development of mesenchymal stem cells (MSCs) for transplantation in spinal cord injury therapy. Of 258 originally identified articles 51 were selected that specifically addressed the stated purpose. Results Recent work has revealed that hUCMSCs share most of the characteristics with MSC

APA, Harvard, Vancouver, ISO, and other styles

20

Arutyunyan, I. V., A. V. Makarov, A. V. Elchaninov, and T. Kh Fatkhudinov. "Umbilical cord-derived multipotent mesenchymal stromal cells: biological properties and clinical applications." Genes & Cells 10, no. 2 (2015): 30–38. http://dx.doi.org/10.23868/gc120474.

Full text

Abstract:

The article presents the current literature evidence and own data on the origin and properties of human umbilical cord-derived multipotent mesenchymal stromal cells including proliferative potential, plasticity, stability of caryotype and phenotype, and immunomodulatory activity A review of clinical trials using this cell type is performed Prospects for the use of multipotent stromal cells, derived from umbilical cord, in cell transplantation associate with the need for specialized biobanking and transplant standardization criteria

APA, Harvard, Vancouver, ISO, and other styles

21

Lu, Lulu, Yong-jun Liu, Zhen-shu Xu, et al. "A Novel Method of Isolation of Mesenchymal Stem Cells from Human Umbilical Cord Tisssues." Blood 106, no. 11 (2005): 4306. http://dx.doi.org/10.1182/blood.v106.11.4306.4306.

Full text

Abstract:

Abstract Mesenchymal stem cells (MSCs) have been isolated from venous endothelia and subendothelia of the human umbilical cord using a tedious procedure. We established a simple method to isolate abundant MSCs from human umbilical cord tissues (UC). 36 full-term umbilical cords were obtained. MSCs were isolated after enzyme digestion of minced cord fragments. The mean nucleated cells isolated from UC was 1.13±0.37×106/cm UC. A total of 1×10e10 MSCs was obtained after several passages over 4 weeks. CFU-F frequency is 1:1609. The population doubling time was approximately 28.02±10.53 h in passag

APA, Harvard, Vancouver, ISO, and other styles

22

Wu, Shuai, Zhongliang Cheng, Guohua Liu, et al. "Urothelial Differentiation of Human Umbilical Cord-Derived Mesenchymal Stromal CellsIn Vitro." Analytical Cellular Pathology 36, no. 3-4 (2013): 63–69. http://dx.doi.org/10.1155/2013/274640.

Full text

Abstract:

Human umbilical cord-derived mesenchymal stromal cells (hUCMSCs) are the most primitive of those isolated from other post-natal tissue source. The hUCMSCs possess the capability of differentiating along multi-lineage. This study aimed to investigate whether hUCMSCs can differentiate into urothelium-like cells. The hUCMSCs were isolated from fresh human umbilical cord postpartum and expanded at least to passage 3in vitro. Subsequently, they were cultured with conditioned medium from urothelial cells (UC-CM) supplemented with 20 ng/ml exogenous epidermal growth factor (EGF). Urothelial cell spec

APA, Harvard, Vancouver, ISO, and other styles

23

Esmaeli, Azadeh, Mojgan Moshrefi, Ali Shamsara, Seyed Hasan Eftekhar-vaghefi, and Seyed Noureddin Nematollahi-mahani. "Xeno-free culture condition for human bone marrow and umbilical cord matrix-derived mesenchymal stem/stromal cells using human umbilical cord blood serum." International Journal of Reproductive BioMedicine 14, no. 9 (2016): 567–76. http://dx.doi.org/10.29252/ijrm.14.9.567.

Full text

APA, Harvard, Vancouver, ISO, and other styles

24

Deryabina, Olena, Yuriy Minin, Halyna Karas, et al. "Human umbilical cord-derived mesenchymal stem cells promote regeneration of nasal mucosa atrophy." OTORHINOLARYNGOLOGY No5(5) 2022, No5(5) 2022 (October 31, 2022): 46–54. http://dx.doi.org/10.37219/2528-8253-2022-5-46.

Full text

Abstract:

Introduction: Mesenchymal multipotent stromal cells (mesenchymal stem cells-MSCs) are currently the most promising and widely used means of cell therapy. Common sources for obtaining them are bone marrow and adipose tissue, but now the umbilical cord and placenta are gaining more and more popularity, since the cells isolated from them have a number of advantages over other sources. Aim: To study the peculiarities of human umbilical cord MSCs influence of on the regeneration of the mucous membrane of the nasal cavity in experimentally induced atrophy. Materials and methods: 30 laboratory mice w

APA, Harvard, Vancouver, ISO, and other styles

25

Bojanic, Christine, Kendrick To, Bridget Zhang, Christopher Mak, and Wasim S. Khan. "Human umbilical cord derived mesenchymal stem cells in peripheral nerve regeneration." World Journal of Stem Cells 12, no. 4 (2020): 288–302. http://dx.doi.org/10.4252/wjsc.v12.i4.288.

Full text

APA, Harvard, Vancouver, ISO, and other styles

26

Gong, Wei, Zhibo Han, Hui Zhao, et al. "Banking Human Umbilical Cord-Derived Mesenchymal Stromal Cells for Clinical Use." Cell Transplantation 21, no. 1 (2012): 207–16. http://dx.doi.org/10.3727/096368911x586756.

Full text

APA, Harvard, Vancouver, ISO, and other styles

27

Zhang, Hao, Yanling Tao, Haihui Liu, Saisai Ren, Bin Zhang, and Hu Chen. "Immunomodulatory function of whole human umbilical cord derived mesenchymal stem cells." Molecular Immunology 87 (July 2017): 293–99. http://dx.doi.org/10.1016/j.molimm.2017.03.003.

Full text

APA, Harvard, Vancouver, ISO, and other styles

28

Yaghoubi, Yoda, AliAkbar Movassaghpour, Majid Zamani, Mehdi Talebi, Amir Mehdizadeh, and Mehdi Yousefi. "Human umbilical cord mesenchymal stem cells derived-exosomes in diseases treatment." Life Sciences 233 (September 2019): 116733. http://dx.doi.org/10.1016/j.lfs.2019.116733.

Full text

APA, Harvard, Vancouver, ISO, and other styles

29

Fan, Cun-Gang, Qing-jun Zhang, and Jing-ru Zhou. "Therapeutic Potentials of Mesenchymal Stem Cells Derived from Human Umbilical Cord." Stem Cell Reviews and Reports 7, no. 1 (2010): 195–207. http://dx.doi.org/10.1007/s12015-010-9168-8.

Full text

APA, Harvard, Vancouver, ISO, and other styles

30

Tam, D., A. Chan, and B. Yau. "Ultrastructure of human umbilical cord derived mesenchymal stem cells (HUC-MSCs)." Cytotherapy 19, no. 5 (2017): S194—S195. http://dx.doi.org/10.1016/j.jcyt.2017.02.284.

Full text

APA, Harvard, Vancouver, ISO, and other styles

31

Filiano, A., A. Saha, H. Min, et al. "Targeting neuroinflammation with human umbilical cord tissue-derived mesenchymal stromal cells." Cytotherapy 20, no. 5 (2018): S104—S105. http://dx.doi.org/10.1016/j.jcyt.2018.02.305.

Full text

APA, Harvard, Vancouver, ISO, and other styles

32

Min, Hyunjung. "Targeting Neuroinflammation with Human Umbilical Cord Tissue-Derived Mesenchymal Stromal Cells." STEM CELLS Translational Medicine 7 (September 2018): S4. http://dx.doi.org/10.1002/sctm.12355.

Full text

APA, Harvard, Vancouver, ISO, and other styles

33

Sun, Y., Y. Ding, H. Wu, C. Wu, and S. Li. "CHONDROCYTE-TARGETED EXOSOMES FROM UMBILICAL CORD-DERIVED MESENCHYMAL STEM CELLS FOR OSTEOARTHRITIS THERAPY." Orthopaedic Proceedings 105-B, SUPP_7 (2023): 112. http://dx.doi.org/10.1302/1358-992x.2023.7.112.

Full text

Abstract:

Osteoarthritis (OA) is a common age-related degenerative joint disease, affecting 7% of the global population, more than 500 million people worldwide. Exosomes from mesenchymal stem cells (MSCs) showed promise for OA treatment, but the insufficient biological targeting weakens its efficacy and might bring side effects. Here, we report the chondrocyte-targeted exosomes synthesized via click chemistry as a novel treatment for OA.Exosomes are isolated from human umbilical cord-derived MSCs (hUC-MSCs) using multistep ultracentrifugation process, and identified by electron microscope and nanopartic

APA, Harvard, Vancouver, ISO, and other styles

34

Lee, Mark, Heesun Hong, Sung Yong Kim, Yo Han Cho, and So Young Yoon. "Role of Homing Regulation in Coculturing Human Cord blood–derived Mesenchymal Stem cells with CD34-Positive Cells from Umbilical Cord Blood." Blood 112, no. 11 (2008): 4747. http://dx.doi.org/10.1182/blood.v112.11.4747.4747.

Full text

Abstract:

Abstract Background and Objectives Mesenchymal stem cells plays an important role in the hematopoietic stem cell engraftment condition with SDF-1 (CXCL12)-CXCR4 signaling and in their homing in various tissues. In this study, we evaluated that the regulation of homing efficiency for mesenchymal stem cells to support ex vivo expansion of hematopoietic stem cells from umbilical cord blood. Methods We investigated the expression of CXCR4 and Stromal-Derived Factor-1 (SDF-1) in cocultured mesenchymal stem cell with umbilical cord blood-derived CD34-positive cell, which stimulated with granulocyte

APA, Harvard, Vancouver, ISO, and other styles

35

Reyhani, Samira, Bahareh Abbaspanah, and Seyed Hadi Mousavi. "Umbilical cord-derived mesenchymal stem cells in neurodegenerative disorders: from literature to clinical practice." Regenerative Medicine 15, no. 4 (2020): 1561–78. http://dx.doi.org/10.2217/rme-2019-0119.

Full text

Abstract:

Mesenchymal stem cells (MSCs) have provided a promising tool for cell therapy. Umbilical cord (UC) is one of the best sources of MSCs since its collection is noninvasive, and effortless, and the cells from this source are more capable and prolific. It has been proven that the differentiation, migration and protective properties of UC-MSCs are superior compared with other kinds of stem cells. Moreover, incurable neurodegenerative diseases, such as Alzheimer’s disease, multiple sclerosis, Parkinson’s disease and Huntington, encourage scientists to apply UC-MSCs transplantation in order to find a

APA, Harvard, Vancouver, ISO, and other styles

36

Liu, Xiaozhen, Long Zhou, Xi Chen, et al. "Culturing on decellularized extracellular matrix enhances antioxidant properties of human umbilical cord-derived mesenchymal stem cells." Materials Science and Engineering: C 61 (April 2016): 437–48. http://dx.doi.org/10.1016/j.msec.2015.12.090.

Full text

APA, Harvard, Vancouver, ISO, and other styles

37

Jing, Wang, Wang Zhiguo, Cai Xia, Li kun, Hao Rongan, and An Yu. "Research Progress on Exosomes Derived from Human Adipose Mesenchymal Stem Cells." International Journal of Sciences Volume 8, no. 2019-03 (2019): 114–17. https://doi.org/10.5281/zenodo.3350635.

Full text

Abstract:

Mesenchymal stem cells (MSC) have the potential of multi-directional differentiation, have stable genetic information, can self-replicate and renew, and are commonly used as seed cells in the field of regeneration1. Adipose mesenchymal stem cells, bone marrow mesenchymal stem cells and umbilical cord mesenchymal stem cells are the most commonly used mesenchymal stem cells. Compared with other mesenchymal stem cells, adipose mesenchymal stem cells have a wide range of sources, relatively simple acquisition methods and less trauma2. Therefore, adipose mesenchymal stem cells have gradually become

APA, Harvard, Vancouver, ISO, and other styles

38

Jerkic, Mirjana, Stéphane Gagnon, Razieh Rabani, et al. "Human Umbilical Cord Mesenchymal Stromal Cells Attenuate Systemic Sepsis in Part by Enhancing Peritoneal Macrophage Bacterial Killing via Heme Oxygenase-1 Induction in Rats." Anesthesiology 132, no. 1 (2020): 140–54. http://dx.doi.org/10.1097/aln.0000000000003018.

Full text

Abstract:

Abstract Editor’s Perspective What We Already Know about This Topic What This Article Tells Us That Is New Background Mesenchymal stromal cells have therapeutic potential in sepsis, but the mechanism of action is unclear. We tested the effects, dose-response, and mechanisms of action of cryopreserved, xenogeneic-free human umbilical cord mesenchymal stromal cells in a rat model of fecal peritonitis, and examined the role of heme oxygenase-1 in protection. Methods Separate in vivo experiments evaluated mesenchymal stromal cells in fecal sepsis, established dose response (2, 5, and 10 million ce

APA, Harvard, Vancouver, ISO, and other styles

39

Yang, Xiao-Fei, Tao Chen, Li-Wei Ren, Lu Yang, Hui Qi, and Fu-Rong Li. "Immunogenicity of insulin-producing cells derived from human umbilical cord mesenchymal stem cells." Experimental and Therapeutic Medicine 13, no. 4 (2017): 1456–64. http://dx.doi.org/10.3892/etm.2017.4096.

Full text

APA, Harvard, Vancouver, ISO, and other styles

40

Chao, Yu-Hua, Han-Ping Wu, Chin-Kan Chan, Chris Tsai, Ching-Tien Peng, and Kang-Hsi Wu. "Umbilical Cord-Derived Mesenchymal Stem Cells for Hematopoietic Stem Cell Transplantation." Journal of Biomedicine and Biotechnology 2012 (2012): 1–5. http://dx.doi.org/10.1155/2012/759503.

Full text

Abstract:

Hematopoietic stem cell transplantation (HSCT) is becoming an effective therapeutic modality for a variety of diseases. Mesenchymal stem cells (MSCs) can be used to enhance hematopoietic engraftment, accelerate lymphocyte recovery, reduce the risk of graft failure, prevent and treat graft-versus-host disease, and repair tissue damage in patients receiving HSCT. Till now, most MSCs for human clinical application have been derived from bone marrow. However, acquiring bone-marrow-derived MSCs involves an invasive procedure. Umbilical cord is rich with MSCs. Compared to bone-marrow-derived MSCs, u

APA, Harvard, Vancouver, ISO, and other styles

41

Ma, Lian, Xueyong Feng, Liye Yang, Minjie Luo, Qingdong Xie, and Tianhua Huang. "Induction of Human Umbilical Cord Blood Mesenchymal Stem Cells into Nerve-Like Cells by Salvia Miltiorrhiza." Blood 106, no. 11 (2005): 4227. http://dx.doi.org/10.1182/blood.v106.11.4227.4227.

Full text

Abstract:

Abstract Salvia miltiorrhiza is a traditional Chinese herb with thousands of years history. Composite salvia injection (CSI), a widely used administration in China nowadays, consists of Salvia miltiorrhiza, notoginseng, radix and borneo. It can promote blood flow, but also regulate qi to alleviate pain. So it is frequently used for angina, coronary heart disease and chest discomfort. Recently, some laboratory studies show that CSI may have the effect of cell induction.. In this study, we aim to investigate its neural induction. Objective: To investigate the differentiation-inducing effects of

APA, Harvard, Vancouver, ISO, and other styles

42

Yu, Yue, Liangliang Shen, Xiaoyun Xie, Jingjun Zhao, and Miao Jiang. "The Therapeutic Effects of Exosomes Derived from Human Umbilical Cord Mesenchymal Stem Cells on Scleroderma." Tissue Engineering and Regenerative Medicine 19, no. 1 (2021): 141–50. http://dx.doi.org/10.1007/s13770-021-00405-5.

Full text

Abstract:

Abstract Background: Scleroderma is a multisystem disease in which tissue fibrosis is caused by inflammation and vascular damage. The mortality of scleroderma has remained high due to a lack of effective treatments. However, exosomes derived from human umbilical cord mesenchymal stem cells (HUMSCs)-Ex have been regarded as potential treatments for various autoimmune diseases, and may also act as candidates for treating scleroderma. Methods: Mice with scleroderma received a single 50 μg HUMSCs-Ex. HUMSCs-Ex was characterized using transmission electron microscopy, nanoparticle tracking analysis

APA, Harvard, Vancouver, ISO, and other styles

43

Nam, Sang Min, Yong-Sun Maeng, Eung Kweon Kim, Kyoung Yul Seo, and Helen Lew. "Ex Vivo Expansion of Human Limbal Epithelial Cells Using Human Placenta-Derived and Umbilical Cord-Derived Mesenchymal Stem Cells." Stem Cells International 2017 (2017): 1–10. http://dx.doi.org/10.1155/2017/4206187.

Full text

Abstract:

Ex vivo culture of human limbal epithelial cells (LECs) is used to treat limbal stem cell (LSC) deficiency, a vision loss condition, and suitable culture systems using feeder cells or serum without animal elements have been developed. This study evaluated the use of human umbilical cord or placenta mesenchymal stem cells (C-MSCs or P-MSCs, resp.) as feeder cells in an animal/serum-free coculture system with human LECs. C-/P-MSCs stimulated LEC colony formation of the stem cell markers (p63, ABCG2) and secreted known LEC clonal growth factors (keratinocyte growth factor, β-nerve growth factor).

APA, Harvard, Vancouver, ISO, and other styles

44

Oostendorp, Robert A. J., Nicole Mohaupt, Nikolas Kaltz, Sandra Hippauf, and Christian Peschel. "Frequency of Mesenchymal Colony-Forming Cells (CFU-F) from Human Cord Blood and the Umbilical Vein." Blood 106, no. 11 (2005): 4309. http://dx.doi.org/10.1182/blood.v106.11.4309.4309.

Full text

Abstract:

Abstract Umbilical cord blood (UCB) is frequently collected for the purpose of hematopoietic stem cell therapy. However, the use of these cells is infrequent. To investigate other possible applications we recently showed that UCB is an excellent source of endothelial colony-forming cells which improve vessel density and heart function ofter myocardial infarction (Ott, Keller, et al., FASEB J, 2005;19:992–4). We here investigated whether UCB or the umbilical cord would be suitable as a routine source of mesenchymal colony-forming cells (CFU-F). CD34+ and AC133+ cells were selected by MACS (Milt

APA, Harvard, Vancouver, ISO, and other styles

45

Xu, Lu, Jianjun Zhou, Jingyu Liu, et al. "Different Angiogenic Potentials of Mesenchymal Stem Cells Derived from Umbilical Artery, Umbilical Vein, and Wharton’s Jelly." Stem Cells International 2017 (2017): 1–15. http://dx.doi.org/10.1155/2017/3175748.

Full text

Abstract:

Human mesenchymal stem cells derived from the umbilical cord (UC) are a favorable source for allogeneic cell therapy. Here, we successfully isolated the stem cells derived from three different compartments of the human UC, including perivascular stem cells derived from umbilical arteries (UCA-PSCs), perivascular stem cells derived from umbilical vein (UCV-PSCs), and mesenchymal stem cells derived from Wharton’s jelly (WJ-MSCs). These cells had the similar phenotype and differentiation potential toward adipocytes, osteoblasts, and neuron-like cells. However, UCA-PSCs and UCV-PSCs had more CD146

APA, Harvard, Vancouver, ISO, and other styles

46

Robert, Anny Waloski, Andressa Vaz Schittini, Fabricio Klerynton Marchini, et al. "Tissue-Derived Signals for Mesenchymal Stem Cell Stimulation: Role of Cardiac and Umbilical Cord Microenvironments." Cells Tissues Organs 203, no. 3 (2016): 173–82. http://dx.doi.org/10.1159/000450600.

Full text

Abstract:

The tissue microenvironment regulates such stem cell behaviors as self-renewal and differentiation. Attempts to mimic components of these microenvironments could provide new strategies for culturing and directing the behavior of stem cells. The aim of the present study was to mimic cardiac and umbilical cord tissue microenvironments in vitro and compare the resulting bone marrow-derived mesenchymal stem cell (BM-MSC) behaviors. We generated tissue microenvironments using conditioned medium (CM) and extracellular matrix (ECM) samples obtained from human heart and umbilical cord tissue explant c

APA, Harvard, Vancouver, ISO, and other styles

47

Rajput, Shafiqa Naeem, Bushra Kiran Naeem, Anwar Ali, Asmat Salim, and Irfan Khan. "Expansion of human umbilical cord derived mesenchymal stem cells in regenerative medicine." World Journal of Stem Cells 16, no. 4 (2024): 410–33. http://dx.doi.org/10.4252/wjsc.v16.i4.410.

Full text

Abstract:

BACKGROUND Stem cells are undifferentiated cells that possess the potential for self-renewal with the capacity to differentiate into multiple lineages. In humans, their limited numbers pose a challenge in fulfilling the necessary demands for the regeneration and repair of damaged tissues or organs. Studies suggested that mesenchymal stem cells (MSCs), necessary for repair and regeneration via transplantation, require doses ranging from 10 to 400 million cells. Furthermore, the limited expansion of MSCs restricts their therapeutic application. AIM To optimize a novel protocol to achieve qualita

APA, Harvard, Vancouver, ISO, and other styles

48

Mato-Basalo, Rocío, Miriam Morente-López, Onno J. Arntz, Fons A. J. van de Loo, Juan Fafián-Labora, and María C. Arufe. "Therapeutic Potential for Regulation of the Nuclear Factor Kappa-B Transcription Factor p65 to Prevent Cellular Senescence and Activation of Pro-Inflammatory in Mesenchymal Stem Cells." International Journal of Molecular Sciences 22, no. 7 (2021): 3367. http://dx.doi.org/10.3390/ijms22073367.

Full text

Abstract:

Mesenchymal stem cells have an important potential in the treatment of age-related diseases. In the last years, small extracellular vesicles derived from these stem cells have been proposed as cell-free therapies. Cellular senescence and proinflammatory activation are involved in the loss of therapeutic capacity and in the phenomenon called inflamm-aging. The regulators of these two biological processes in mesenchymal stem cells are not well-known. In this study, we found that p65 is activated during cellular senescence and inflammatory activation in human umbilical cord-derived mesenchymal st

APA, Harvard, Vancouver, ISO, and other styles

49

Zhang, Jingbo, Xiang Qu, Junjun Li, et al. "Tissue Sheet Engineered Using Human Umbilical Cord-Derived Mesenchymal Stem Cells Improves Diabetic Wound Healing." International Journal of Molecular Sciences 23, no. 20 (2022): 12697. http://dx.doi.org/10.3390/ijms232012697.

Full text

Abstract:

Diabetic foot ulceration is a common chronic diabetic complication. Human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) have been widely used in regenerative medicine owing to their multipotency and easy availability. We developed poly(lactic-co-glycolic acid) (PLGA)-based scaffold to create hUC-MSC tissue sheets. In vitro immunostaining showed that hUC-MSC tissue sheets formed thick and solid tissue sheets with an abundance of extracellular matrix (ECM). Diabetic wounds in mice treated with or without either the hUC-MSC tissue sheet, hUC-MSC injection, or fiber only revealed that h

APA, Harvard, Vancouver, ISO, and other styles

50

Tang, Haoshuai, Junjin Li, Hongda Wang, et al. "Human umbilical cord mesenchymal stem cell-derived exosomes loaded into a composite conduit promote functional recovery after peripheral nerve injury in rats." Neural Regeneration Research 19, no. 4 (2023): 900–907. http://dx.doi.org/10.4103/1673-5374.380911.

Full text

Abstract:

JOURNAL/nrgr/04.03/01300535-202404000-00036/inline-graphic1/v/2023-09-09T133047Z/r/image-tiff Complete transverse injury of peripheral nerves is challenging to treat. Exosomes secreted by human umbilical cord mesenchymal stem cells are considered to play an important role in intercellular communication and regulate tissue regeneration. In previous studies, a collagen/hyaluronic acid sponge was shown to provide a suitable regeneration environment for Schwann cell proliferation and to promote axonal regeneration. This three-dimensional (3D) composite conduit contains a collagen/hyaluronic acid i

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!