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Dissertations / Theses on the topic 'Humman Immunodeficiency Virus'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

Wilson, Colleen. "Nurses with human immunodeficiency virus or acquired immunodeficiency syndrome." Thesis, McGill University, 1996. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=23974.

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This thesis will explore the various legal, administrative and ethical issues arising out of the situation in which nurse is HIV-positive or has AIDS. In contrast to the situation of patients suffering from AIDS or HIV, there has been little in the literature, whether legal or medical, on nurses who are infected. The rights and duties of these nurses, testing of nurses for the presence of HIV infection or AIDS and the issue of discrimination are among the matters discussed with reference to relevant legislation and ethical principles.

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2

Brettle, Raymond Patrick. "Human immunodeficiency virus : the Edinburgh epidemic." Thesis, University of Edinburgh, 1995. http://hdl.handle.net/1842/20883.

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For a variety of socio-economic reasons an epidemic of injection drug use (IDU) involving heroin occurred during the early 1980's in Edinburgh: one third were female, most were young, unemployed and living on large council estates. At the peak of this IDU epidemic, HIV arrived and rapidly spread through this community. By July 1989 over 1000 individuals or 0.1% of the population of Lothian (750,000) had been recognised to have been infected with HIV, the majority via IDU. This is of the same order as the worst affected region in England (North West Thames). The majority of these individuals ho

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3

Walker, S. M. "Transactivation of human immunodeficiency virus by human cytomegalovirus." Thesis, University of Cambridge, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.387104.

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4

Cochrane, Alexandra. "Human immunodeficiency virus infection of CD8 lymphocytes." Thesis, University of Edinburgh, 2006. http://hdl.handle.net/1842/24468.

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To confirm that CD8 lymphocytes are infected with HIV <i>in vivo</i>, and to investigate the mechanism of infection, HIV long terminal repeat (LTR) DNA was quantified in CD8 lymphocyte subsets of known purity, isolated from the blood of 20 subjects with HIV infection. HIV LTR was demonstrated in CD8 lymphocytes of 18/20 subjects, and in the subjects with chronic infection the frequency of infection increased with disease progression. HIV infection of CD8<sup>bright</sup>CD4<sup>dim</sup> lymphocytes was significantly more frequent (median 1197 HIV LTR copies / million cells) than that of CD8+C

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5

Langeni, Delile Gertrude. "Self-Disclosure of Human Immunodeficiency Virus Status in Personal Relationships: Perceptions of South Africans Living with Human Immunodeficiency Virus." ScholarWorks, 2018. https://scholarworks.waldenu.edu/dissertations/4798.

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Despite enormous research on the experience of living with HIV, many questions remain regarding self-disclosure of HIV status to sexual partners by people living with HIV (PLWHIV), which is essential to reducing further infection. In this study, a phenomenological approach captured the experience of self-disclosure among South Africans living with HIV in Louwsburg, South Africa. The health belief model served as a theoretical framework, and in-depth interviews were conducted with 12 PLWHIV (8 women, 4 men) who self-disclosed their HIV status to their sexual partners. Their experiences were exp

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6

Loo, Ryan K. "Sampling Considerations in Human Immunodeficiency Virus and Acquired Immunodeficiency Syndrome Needs Assessments." DigitalCommons@USU, 2003. https://digitalcommons.usu.edu/etd/6179.

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The human immunodeficiency virus (HIV) reduces the number of healthy immune cells in the human body. When the immune cells drop below a certain level, the person is diagnosed as having acquired immunodeficiency syndrome (AIDS), which increases the likelihood of opportunistic infections. As a result, people living with HIV I AIDS (PL WH/ A) have an elevated need for medical and support services. HIV I AIDS needs assessments identify unmet needs, and the results are used in the allocation of resources. Failure to accurately identify needs due to nonrepresentative samples may result in PL WH/ A f

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7

Shi, Ruili. "Biological studies on inhibitors of human immunodeficiency virus." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape9/PQDD_0024/NQ37913.pdf.

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8

McKiel, Vanessa. "Cytokine-induced alterations in human immunodeficiency virus multiplication." Thesis, McGill University, 1994. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=55512.

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The ability of the human immunodeficiency virus (HIV) to replicate in T-cells and macrophages has been shown to be influenced by immunomodulatory cytokines; furthermore, HIV infection of these cells can alter the kinetics of cytokine transcription. We found that chronic HIV IIIB infection of myelomonoblastic PLB 985 cells resulted in an altered pattern of type 1 interferon (IFN) transcription. Paradoxically, despite the antiviral effects of IFN, HIV-induced dysregulation of IFN transcription may actually lead to the establishment of a cellular environment that supports a chronic infection.<br>

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9

Harrison, Thomas Stephen. "Interactions between Human Immunodeficiency Virus and Cryptococcus neoformans." Thesis, St George's, University of London, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.299059.

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10

Chua, Ser Ling. "Papular pruritic eruption of human immunodeficiency virus infection." Thesis, University of Nottingham, 2015. http://eprints.nottingham.ac.uk/30750/.

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Background Papular pruritic eruption (PPE) of human immunodeficiency virus (HIV) infection is common HIV-infected populations who live in tropical and subtropical regions. It is characterized by chronic and intensely itchy papules that are usually more highly concentrated on the extremities, adversely impacting on quality of life. Its aetiology has been postulated to be an altered and exaggerated immunological response to insect bites or stings. It has been reported to diminish in severity or resolve with antiretroviral therapy (ART). Its presence after at least six months of ART has been prop

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11

Gao, Zhanhai School of Mathematics UNSW. "Modelling Human Immunodeficiency Virus and Hepatitis C Virus Epidemics in Australia." Awarded by:University of New South Wales. School of Mathematics, 2001. http://handle.unsw.edu.au/1959.4/18187.

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This thesis is concerned with the mathematical modelling for human immunodeficiency virus (HIV) and hepatitis C virus (HCV) epidemics in Australia. There are two parts to this thesis. Part I is aimed at modelling the transmission of HIV and HCV via needle sharing among injecting drug users (IDUs). The dynamical model of an epidemic through needle sharing among IDUs is derived. This model reveals the correlation between needle sharing and the epidemic prevalence among IDUs. The simulations of HIV and HCV prevalence and incidence among IDUs in Australia are made with this model. The comparison

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12

Pise-Masison, Cynthia Ann. "Human Immunodeficiency Virus Type-1 Infection of Human Myeloid Cells." eScholarship@UMMS, 1994. https://escholarship.umassmed.edu/gsbs_diss/87.

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Infection with human immunodeficiency virus type 1 (HIV-1) results in a wide range of immunologic and hematopoietic abnormalities. The overall goal of this dissertation was directed toward obtaining a better understanding of the interactions of HIV-1 and myeloid cells in relation to the pathogenesis of AIDS. The human myelomonocytic cell line, HL-60, was used as a model system to determine if HIV-1 infects myeloid progenitor cells and subsequently, if infection affects their differentiation. HL-60 cells and the human prototypic T cell line, H9 were infected with three different HIV-l isolates

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13

Heusinger, Elena [Verfasser]. "Preadaptation of Simian Immunodeficiency Virus SIVsmm Facilitated Env-Mediated Counteraction of Human Tetherin by Human Immunodeficiency Virus Type 2 / Elena Heusinger." Ulm : Universität Ulm, 2019. http://d-nb.info/1177882604/34.

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14

Ollerton, Matthew T. "Capacity of Human Immunodeficiency Virus Targeting Chimeric Antigen Receptor T Cells to Eliminate Follicular Dendritic Cells Bearing Human Immunodeficiency Virus Immune Complexes." BYU ScholarsArchive, 2017. https://scholarsarchive.byu.edu/etd/7240.

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An important obstacle to a functional cure for HIV/AIDS is the persistence of viral reservoirs found throughout the body in various cells and tissues. Reservoirs can be latently infected cells, or in the case of follicular dendritic cells (FDC), non-infected cells that trap infectious virus on their surface through immune complexes (HIV-IC). Although several strategies have been employed to target and eliminate viral reservoirs, they are short-lived and ineffective. In an attempt to provide a long-term approach, chimeric antigen receptor T (CAR-T) cells were designed to eliminate native HIV on

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15

Li, Yan. "Processing and secretion of human immunodeficiency virus glycoprotein,gp120." Thesis, University of Ottawa (Canada), 1992. http://hdl.handle.net/10393/10962.

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The natural signal sequence of HIV-1 gp120 contains an unusually long hydrophobic domain and five positively charged amino acids. When the gp120 gene was cloned into a baculovirus expression vector under the control of the baculovirus polyhedrin gene promoter, it exhibited an extremely low level of secretion. However, deletion of the signal sequence resulted in the production of large quantities of a nonglycosylated form of gp120 and fusion of honeybee melittin or murine interleukin 3 signal sequences, which contain only one or no positively charged residues, respectively, resulted in a high l

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16

Zeibdawi, Abdul-Rahman. "Recombinant human immunodeficiency virus reverse transcriptases, activity and fidelity." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp04/mq20986.pdf.

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17

Yim, Chi-ho Howard. "Cytokine dysregulation by human immunodeficiency virus-1 transactivating protein." Click to view the E-thesis via HKUTO, 2006. http://sunzi.lib.hku.hk/hkuto/record/B36987700.

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18

Brasey, Ann. "Translation regulation of the Human Immunodeficiency Virus type 1." Thesis, McGill University, 2005. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=85890.

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Viruses are among the ultimate conquerors. Even the exploits of Genghis Khan and Alexander the Great seem pale when compared to viral feats. To give but one example, over the last 50 years, the human immunodeficiency virus (HIV) has swept across six continents, now claiming several million lives yearly. Despite sustained intense research efforts, there is still no treatment to eradicate HIV infection.<br>For billions of years, viruses evolved strategies to enter and take control of organisms to generate progeny viruses. Eukaryotic cell viruses developed various means of hijacking the ce

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19

Zemmel, Rodney W. "Rev-RRE interactions in human immunodeficiency virus gene expression." Thesis, University of Cambridge, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.390234.

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20

Yim, Chi-ho Howard, and 嚴志濠. "Cytokine dysregulation by human immunodeficiency virus-1 transactivating protein." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2006. http://hub.hku.hk/bib/B36987700.

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21

Reeves, Jacqueline Denise. "CD4-independent infection by human immunodeficiency virus type 2." Thesis, Institute of Cancer Research (University Of London), 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.368031.

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22

Khiytani, Dheeraj K. "Pre-integration complexes of human immunodeficiency virus type 1." Thesis, University of Warwick, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.247285.

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23

Willey, Samantha. "Cellular tropism of human immunodeficiency virus : receptors and inhibitors." Thesis, University College London (University of London), 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.404902.

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24

Boffito, Marta. "Clinical pharmacology of human immunodeficiency virus-1 protease inhibitors." Thesis, University of Liverpool, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.403237.

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25

Jones, Christopher P. "Primer tRNA annealing by human immunodeficiency virus type 1." The Ohio State University, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=osu1337962197.

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26

Burnett, Mary Susan. "Development of a live vaccine for human immunodeficiency virus /." Digital version accessible at:, 1997. http://wwwlib.umi.com/cr/utexas/main.

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27

Cook, Scott C. "Human immunodeficiency virus : determining predictors of unsafe sexual behavior /." free to MU campus, to others for purchase, 1999. http://wwwlib.umi.com/cr/mo/fullcit?p9962514.

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28

Jordán, de Paiz Ana. "Synonymous changes in the human immunodeficiency virus genome as a strategy to study virus biology." Doctoral thesis, Universitat Autònoma de Barcelona, 2019. http://hdl.handle.net/10803/669843.

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La recodificación sinónima de los genomas se ha usado ampliamente para estudiar diferentes aspectos de la biología de los virus. Esta herramienta se basa en modificar la secuencia de nucleótidos de un gen sin cambiar la secuencia de aminoácidos, es decir, la secuencia de la proteína no se ve afectada. Estudios previos han demostrado atenuación viral debida a una reducción en la expresión proteica después de llevar a cabo la recodificación sinónima. De la misma manera, esta herramienta ha permitido la identificación de estructuras secundarias del ARN, la descripción de factores virales o intera

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29

Mboto, Clement Ibi. "Studies on Human Immunodeficiency Virus and hepatitus C virus coinfection in the Gambia." Thesis, Kingston University, 2005. http://eprints.kingston.ac.uk/20370/.

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Co-infection with Hepatitis C Virus (HCV) is a common occurrence in Human Immunodeficiency Virus (HIV)-positive patients and an increasing cause of morbidity and mortality. Little is known however of the burden or the natural history of these infections or their interactions in most parts of sub-Saharan Africa, where both viruses are endemic. In this study a total of 1500 people aged 11 months to 76 years referred to the serology unit of Royal Victoria Teaching Hospital between the months of July to December 2003 were evaluated for anti-HIV, anti-HCV and CD4+ T-cell count and compared with the

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30

Iwatani, Yasumasa. "Human Immunodeficiency Virus Type 1 Vpu modifies Cytopathic Effect through Augmented Virus Release." Kyoto University, 1997. http://hdl.handle.net/2433/202156.

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31

Matthews, James Robert. "Transcriptional activation of human immunodeficiency virus type 1 by NF-κb". Thesis, University of St Andrews, 1993. http://hdl.handle.net/10023/13981.

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This study has analysed some of the mechanisms involved in the transcriptional activation of the human immunodeficiency virus type 1 (HIV-1) by transcriptional modulator proteins of the NF-ĸB/rel family. Initial attempts to purify a single NF-ĸB (p50-p65) heterodimer species from HeLa cells suggested that a family of proteins might contribute to ĸB motif DNA binding activity. HeLa cell ĸB motif DNA binding proteins were shown to be modified by glycosylation. Using circularly permuted DNA probes carrying a KB motif, it was shown that ĸB binding proteins induced significant DNA bending upon bind

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32

Scholes, Andrea Gwendoline Mary. "Effect of human immunodeficiency virus infection on oral shedding of human herpesviruses." Thesis, University of Liverpool, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.295830.

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33

Meys, Rhonda. "Aspects of human papillomavirus (HPV) disease in human immunodeficiency virus (HIV) infection." Thesis, Imperial College London, 2013. http://hdl.handle.net/10044/1/10730.

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Cutaneous and genital human papillomavirus (HPV) infection in HIV patients, on suppressive anti-retroviral therapy (ART), poses under-investigated clinical challenges. HPV in HIV may represent a form of immune reconstitution associated disease (IRAD). HPV disease and IRADs have been separately correlated with human leucocyte antigen (HLA) genotype. HLA might also influence HPV in HIV. Comprehensive HPV typing of persistent warts obtained from HIV infected and healthy subjects was performed. Cutaneous HPV types were detected using nested PCR/sequencing and newly developed (Luminex based) HSLPCR

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34

Khalouei, Sam. "Translation initiation in human immunodeficiency virus type 1 (HIV-1)." Thesis, University of Ottawa (Canada), 2007. http://hdl.handle.net/10393/27866.

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Translation of human immunodeficiency virus type 1 (HIV-1) mRNAs is entirely dependent on the host translation machinery. There are two prevailing hypotheses regarding the translation initiation mechanism in HIV-1; conventional cap-dependent ribosomal scanning mechanism (CDRSM) and cap-independent entry of the ribosome, usually through an internal ribosome entry site (IRES). The first mechanism makes use of the Kozak consensus sequence in locating the translation initiation codon, similar to the mechanism observed in human mRNAs. Therefore, a thorough understanding of the Kozak consensus and t

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35

Chambers, Anthony James St Vincent's Hospital UNSW. "The surgical management of patients with human immunodeficiency virus infection." Awarded by:University of New South Wales. St. Vincent's Hospital, 2001. http://handle.unsw.edu.au/1959.4/19367.

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Infection with the human immunodeficiency virus (HIV) is a major cause of morbidity and death globally, and the number of individuals infected with this virus is increasing in many nations. Advanced HIV infection causes immunocompromise that predisposes to opportunistic infections and malignancies that characterise the acquired immunodeficiency syndrome (AIDS). Although the management of many of these AIDS-associated infections and malignancies is by medical means, surgeons play an important role the diagnosis and management of many of these conditions. Furthermore, patients with HIV infect

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36

Ma, Meihui. "Interactions of human immunodeficiency virus type 1 proteins with astrocytes." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/nq23632.pdf.

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37

Belzile, Jean-Philippe. "Redirecting lentiviral integration : a study of human immunodeficiency virus integrase." Thesis, McGill University, 2006. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=97906.

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Despite great advances in our understanding of the human immunodeficiency virus (HIV) life cycle, the mechanisms that underlie the progression of HIV from cellular entry of the viral core to stable integration of the provirus are poorly understood. Sites of integration of the HIV provirus are distributed along the full length of actively transcribed genes and appear to be determined through protein-protein interactions between the viral integrase and cellular proteins.<br>Two cellular proteins have been proposed to perform integration targeting roles, the chromatin-remodeling factor integrase

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38

D'Addario, Mario G. Jr. "Cytokine gene expression in human immunodeficiency virus infected myeloid cells." Thesis, McGill University, 1992. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=56776.

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Results indicate that U9-IIIB and PLB-IIIB cells stimulated with PMA, LPS or recombinant cytokines transcribed and translated significantly higher levels of TNF-$ alpha$, IL-1$ alpha$, IFN-$ alpha$, IL-1$ beta$, and IFN-$ beta$. Furthermore it appears that HIV infection of PLB-985 cells induces monocytic differentiation and alterations in the binding of NF-$ kappa$B related proteins. PLB-IIIB cells demonstrated characteristics reflecting differentiation including morphological alterations, changes in c-fms and c-myc proto-oncogene expression, and increased expression of CD14 cell surface antig

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39

Milev, Miroslav. "Characterizing the staufen 1 human immunodeficiency virus type 1 ribonucleoprotein." Thesis, McGill University, 2011. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=96998.

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Human Immunodeficiency Virus type 1 (HIV-1) is a member of the Retrovirus family and is the causative agent of Acquired Immunodeficiency Syndrome (AIDS). As an obligate intracellular parasite, HIV-1 uses cellular proteins and machinery to ensure transmission to uninfected cells. One such cellular protein involved in the late stages of viral replication is Staufen1. It is a main component of mRNA ribonucleoproteins (RNPs) and plays distinct roles in mRNA transport, translation and decay. In the context of HIV-1, Staufen1 was initially found to be selectively encapsidated into the virions. Subse

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40

Goulder, Philip J. R. "Escape of human immunodeficiency virus from the cellular immune response." Thesis, University of Oxford, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.339291.

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41

Baird, Heather A. "Mechanisms of Intersubtype Recombination of Human Immunodeficiency Virus Type One." Case Western Reserve University School of Graduate Studies / OhioLINK, 2005. http://rave.ohiolink.edu/etdc/view?acc_num=case1120599751.

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42

Watson, Victoria. "The clinical pharmacology of Human Immunodeficiency Virus (HIV) therapy failure." Thesis, University of Liverpool, 2014. http://livrepository.liverpool.ac.uk/18853/.

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The work in my thesis focuses on developing highly sensitive tests, using liquid chromatography-tandem mass spectrometry (LC-MS/MS) for the measurement of antiretroviral drugs within plasma, cells, and cerebral spinal fluid from clinical studies evaluating compartmentalised antiretroviral therapy (ART) pharmacokinetics and forgiveness for missed or late dosing. Firstly I developed and validated a LC-MS/MS assay to quantify the antiretroviral (ARV) drugs, lopinavir, darunavir, ritonavir and raltegravir in peripheral blood mononuclear cells (PBMCs). This intracellular assay included optimising m

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43

Motohara, Makiko. "Influence on thymopoiesis of simian and human immunodeficiency virus infection." Kyoto University, 2007. http://hdl.handle.net/2433/136437.

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Kyoto University (京都大学)<br>0048<br>新制・課程博士<br>博士(人間・環境学)<br>甲第13166号<br>人博第373号<br>新制||人||91(附属図書館)<br>18||D||174(吉田南総合図書館)<br>UT51-2007-H439<br>京都大学大学院人間・環境学研究科相関環境学<br>(主査)教授小松賢志, 助教授倉橋和義, 助教授三浦智行<br>学位規則第4条第1項該当

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44

Anderson, Jon Paul. "Molecular diversity and evolution of human immunodeficiency virus type 1 /." Thesis, Connect to this title online; UW restricted, 1999. http://hdl.handle.net/1773/8049.

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45

Clark, W. Andrew, and Eileen M. Cress. "Nutritional Issues and Positive Living in Human Immunodeficiency Virus/AIDS." Digital Commons @ East Tennessee State University, 2018. https://dc.etsu.edu/etsu-works/2495.

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Key Points: (1) Nutrition management for individuals infected with HIV can be helpful in maintaining lean body weight, combating oxidative stress, reducing complications from hyperglycemia and hyperlipidemia, and managing gastrointestinal function. (2) Patients may need to be individualized to meet each individual's unique requirements. (3) Consideration should be given to including the expertise of a registered dietitian/nutritionist s part of the health care team to promote wellness in the individuals infected with HIV.

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46

Kok, Tuckweng. "Early events in the replication cycle of human immunodeficiency virus /." Title page, contents and abstract only, 1998. http://web4.library.adelaide.edu.au/theses/09PH/09phk79.pdf.

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Thesis (Ph. D.)--University of Adelaide, Dept. of Microbiology & Immunology, 1998.<br>Copy of author's previously published article on back end-paper. Includes bibliographical references (leaves 105-158).

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47

Rocafort, Juncà Muntsa. "Gut microbiome in HIV-1 infection." Doctoral thesis, Universitat Autònoma de Barcelona, 2018. http://hdl.handle.net/10803/666775.

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Una vegada el Virus de la Immunodeficiència Humana tipus 1 (en anglès HIV-1) infecta l’organisme hoste es produeix una ràpida i severa destrucció del teixit limfoide associat a tracte gastrointestinal que inclou, entre d’altres, significants pèrdues cel·lulars del sistema immunitari i epitelial de l’hoste. Seguidament es produeix un increment de la permeabilitat de la paret intestinal que permet la translocació microbiana. Així i doncs, productes i cèl·lules microbianes que normalment queden confinats i controlats dins la llum intestinal ara poden travessar l’epiteli intestinal i entrar en cir

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48

White, Stephen Mark. "Assessing the impact of the Human Immunodeficiency Virus / Acquired Immunodeficiency Syndrome on Volkswagen of South Africa." Thesis, Port Elizabeth Technikon, 2001. http://hdl.handle.net/10948/40.

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This treatise takes the form of an impact study. It is based on a three-month period of research involving literature review, interviews with VWSA officers and a survey of 111 of the 5500 workers who comprised the workforce of the VWSA plant in Uitenhage at that time. The author has attempted to portray the general views of experts in the field of HIV/AIDS corporate impact and impact management. In addition he has attempted to assay the current and forecast policies and practices in respect of the management of the epidemic by VWSA. The workers in the plant were consulted by survey and a varie

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49

Simmonds, Peter. "Detection of antibody responses to infection with herpes simplex virus and human immunodeficiency virus." Thesis, University of Edinburgh, 1988. http://hdl.handle.net/1842/26933.

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50

Alimohammadi, Azin. "An investigation of susceptibility of alveolar macrophages to HIV 1 infection." Thesis, Imperial College London, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.289878.

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