Dissertations / Theses on the topic 'Humoral and cellular immunity'
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Tran, Mai Hue. "Investigations of humoral and cellular immune responses directed against MUCI epithelial mucin in ovarian and breast carcinoma /." St. Lucia, Qld, 2002. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe17997.pdf.
SILVA, Fabiana Leticia da. "Efeitos da amamentação em camundongos esquistossomóticos na imunidade anti-ovalbumina de descendentes adultos deficientes na produção das citocinas IL-12/IL-23." Universidade Federal de Pernambuco, 2014. https://repositorio.ufpe.br/handle/123456789/17158.
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O contato prévio com o leite de mães esquistossomóticas induziu, em camundongos adultos, potencialização da produção de anticorpos e aumento da capacidade de apresentação de antígeno pelos linfócitos B, em resposta ao antígeno heterólogo ovalbumina (OVA). Considerando a imunização com OVA um modelo vacinal, as reações inflamatórias e a produção de anticorpos em resposta a esse antígeno são importantes para o desenvolvimento de uma imunidade satisfatória do hospedeiro. Nesse sentido, as células Th1 e Th17 são importantes fatores para o desenvolvimento dessas respostas. Dessa forma, os camundongos deficientes na produção de IL-12/IL-23 (12p40 knockout-KO) são predispostos a desenvolverem uma resposta Th2 polarizada, tornando-se menos responsivos às vacinações. Diante disso, o presente trabalho investigou o efeito da amamentação em mães infectadas pelo Schistosoma mansoni sobre as imunidades humoral e celular de camundongos adultos C57BL/6 12p40 KO, em resposta ao modelo vacinal acima citado. Foram avaliados: a cinética das reações de hipersensibilidade in vivo; os níveis plasmáticos das imunoglobulinas IgG1 e IgG2a; a produção das citocinas IFN-γ, IL-17, IL-5, IL-6, IL-10 e TGF- pelas células esplênicas e a reação inflamatória provocada no coxim plantar. Para isso, camundongos machos, deficientes na produção de IL-12 e IL-23 (IL-12p40 KO) e camundongos selvagens (wild-type/WT) foram divididos nos seguintes grupos: camundongos IL-12p40 KO amamentados em mães infectadas (AI IL-12p40 KO); camundongos IL-12p40 KO amamentados em mães sem infecção (NANI IL-12p40 KO); camundongos selvagens amamentados em mães infectadas (AI WT) e camundongos selvagens amamentados em mães sem infecção (NANI WT). Cinquenta por cento dos animais de cada grupo foram imunizados com OVA em adjuvante. Os outros 50% porcento restantes permaneceram sem imunização. No grupo AI WT houve aumentado de produção de IgG2a, IL-5, TGF-β e IL-6, com baixos níveis de IL-17, em comparação ao NANI WT. Nos animais AI IL-12p40 KO, a produção de IgG2a, IL-5 e TGF-β foi mais alta do que o grupo NANI IL-12p40 KO e similar ao grupo AI WT, mas a produção de IL-6 foi mais baixa. O grupo AI WT mostrou intenso infiltrado inflamatório de eosinófilos na reação de hipersensibilidade tardia (RHT), com acentuado edema em comparação com o edema menos intenso e infiltrado inflamatório de neutrófilos do grupo NANI WT. Os animais NANI IL-12p40 KO e AI IL-12p40 KO não apresentam RHT, porém a reação inflamatória no AI IL-12p40 KO foi menos intensa que nos NANI IL-12p40 KO. Em conclusão, o contato com antígenos do parasito, através da amamentação, induziu, no descendente adulto, uma melhor resposta de anticorpo neutralizante, mesmo diante da deficiência na produção de IL-12e IL-23. Nesta condição, embora tenha havido uma notável produção de IL-5, a lactação em mães infectadas atenuou a reação inflamatória, provavelmente através da regulação cruzada entre TGF-β e IL-6, modulando, desta forma, o status de hiperativação desses animais.
The previous contact with mothers milk schistosomiasis induced in adult mice enhancement of antibody production and increased antigen presentation capacity by B lymphocytes in response to the heterologous antigen ovalbumin (OA). Considering immunization with OA one vaccine model, inflammatory reactions and antibody production in response to antigen are important for the development of a suitable host immunity. In this sense, the Th1 and Th17 cells are important factors for the development of these responses. Thus, mice deficient in IL-12/IL-23 (12p40 knockout-KO) are likely to develop a polarized Th2 response, making it less responsive to vaccination. Therefore, the present study investigated the effect of breastfeeding in mothers infected with Schistosoma mansoni on the humoral and cellular adult C57BL/6 12p40 KO in response to vaccination model mentioned above. Were evaluated: the kinetics of in vivo hypersensitivity reactions; plasma levels of IgG1 and IgG2a immunoglobulins; the production of the cytokines IFN-γ, IL-17, IL-5, IL-6, IL-10 and TGF-β by spleen cells and the inflammatory reaction induced in the footpad. To this end, male mice deficient in IL-12 and IL-23 (IL-12p40 KO) and wild-type mice (Wild-type/WT) were divided into the following groups: IL-12p40 KO mice suckled by infected mothers (IL-12p40 KO- SIM); IL-12p40 KO mice suckled by uninfected mothers (IL-12p40 KO); Wild-type mice suckled by infected mothers (SIM) and wild-type mice suckled by uninfected mothers (CONTROL). Fifty percent of animals in each group were immunized with OA in adjuvant. The other 50% remaining percent remained without immunization. In the SIM group was increased production of IgG2a, IL-5, TGF-β and IL-6, IL-17 with low levels compared to CONTROL. In animals IL-12p40 KO-SIM the production of IgG2a, IL-5 and TGF-β was higher than the IL-12p40 KO similar to group SIM, but IL-6 production was lower. The SIM group showed intense inflammatory infiltrate of eosinophils in the delayed hypersensitivity reaction (DTH), with severe edema compared with the less intense edema and inflammatory infiltration of neutrophils CONTROL group. The animals IL-12p40 KO and IL-12p40KO-SIM not have DTH, but the inflammatory reaction in the IL-12p40KO-SIM was less intense than in IL-12p40 KO. In conclusion, contact with parasite antigens, through breastfeeding, induced in adult offspring, better neutralizing antibody response, despite the deficiency in the production of IL-12 and IL-23. In this condition, though there has been a remarkable IL-5 production in lactating mothers infected with attenuated inflammatory response, probably via cross regulation between TGF-β and IL-6 modulate thereby the status of hyperactivation of these animals.
Santos, Liliane Almeida Carneiro. "Estudo prospectivo sobre a dinâmica da evolução clínica e imunológica da infecção canina por Leishmania (Leishmania) infantum chagasi em área endêmica de leishmaniose visceral no estado do Pará." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/10/10133/tde-27102016-142051/.
Canine visceral leishmaniasis (CVL) is one of the most important public health problems in Latin America because it usually precedes human disease, American visceral leishmaniais (AVL), being caused by Leishmania (L.) infantum chagasi. In the present prospective study it was analyzed during two years period the prevalence, incidence and dynamics of the clinical-immunological evolution of canine L. (L.) i. chagasi-infection in a cohort of 316 mongrel dogs living in endemic area of AVL in Barcarena municipality, Pará State, Amazonian Brazil, by the combined use of the indirect fluorescence antibody test (IFAT-IgG) and delayed-type hypersensitivity (DTH), as well as the parasite research by the popliteal lymph node aspiration for the diagnosis of infection. The IFAT and DTH reactivity recognized three different immune response profiles: (I) IFAT(+)/DTH(-) (81 dogs), (II) IFAT(-)/DTH(+) (17 dogs), and (III) IFAT(+)/DTH(+) (13 dogs), providing an overall infection prevalence of 35,1% (111/316). In this way, the specific prevalence of profile I 25,6% was higher than those of profiles II 5,4% and III 4,1%. Moreover, the frequency of these profiles among 111 infected dogs showed that the rate 73% of profile I was also higher than those of profiles II 15,3% and III 11,7%. The infection prevalence according to the age groups revealed that the rate 27,5% of ≥1year <7years was higher than those of <1year 5,3% and ≥7years 2,2%, respectively. On the other hand, the overall incidence of infection was 5,7% dogs/month (5,4% profile I, 0,3% profile II and 0,0% profile III). However, it was noted a progressive decreasing in the incidence rates at the following time-points: six (3,6% dogs/month), twelve (1,7% dogs/month) and twenty four (0,4% dogs/month) months of the study. In addition, the infection incidence according to the age groups demonstrated that the rate 6,6% dogs/month of <1year was higher compared to those of 5,3% and 3,3% dogs/month of ≥1year and <7years, and <1year, respectively. The parasitological diagnosis of infection was confirmed in 19% (21/111) at the prevalence survey, being most dogs (85,7%) of the profile I, 61,1% symptomatic and 38,9% asymptomatic ones. Among the remainder 14,3%, the diagnosis was associated to the profile III, 66,6% in asymptomatic and 33,3% in symptomatic dogs. At the incidence survey, the diagnosis was confirmed in 11% of dogs, all from the profile I, 60% asymptomatic and 40% symptomatic ones. With regards to clinical status of all 179 infected dogs diagnosed during two years period, it was observed that among 145 (81%) dogs from the profile I, 82% were asymptomatic and 18% symptomatic ones; among 21 (11,7%) from the profile II, all (100%) were asymptomatic; and among 13 (7,3%) from the profile III, 84,6% were asymptomatic and 15,4 % symptomatic ones. Besides this, it was noted that the clinical conversion from asymptomatic to symptomatic status was principally recorded in dogs from the profile I (40,2%) than those from the profiles II (5,8%) and III (9%). By the other side, only 3,2% dogs from the profile I [IFAT(+)/DTH(-)] converted DTH(+) response, while 80% dogs from the profile II [IFAT(-)/DTH(+)] converted IFAT(+) response. At last, it was demonstrated that 100% of death by CVL occurred amongst dogs from the profile I, being 85,7% from the prevalence and 14,3% from the incidence. Taking together all these results, it seems reasonable that interaction between parasite and canine immune response is principally supported by immunologic profile clearly vulnerable, the profile I [IFAT(+)/DTH(-)], which does not offer any resistance to parasite, became the dog highly susceptible to infection
Rahman, Bhuiyan Taufiqur. "Humoral and cellular immune responses to Helicobacter pylori in Bangladeshi children and adults that may be related to protection /." Götborg : Department of Microbiology and Immunology, Institute of Biomedicine at Sahlgrenska Academy, University of Gotheburg, 2010. http://hdl.handle.net/2077/21536.
Moreira, Iramirton Figueirêdo. "Imunidade humoral e celular de crianças com desnutrição crônica semi-internas no centro de recuperação e educação nutricional, CRE Maceió/AL - 2008." Universidade Federal de Alagoas, 2009. http://repositorio.ufal.br/handle/riufal/643.
A Organização Mundial da Saúde define Desnutrição Energético-Protéica como uma gama de condições patológicas que aparece por deficiência de aporte, transporte ou utilização de nutrientes pelas células do organismo provocando uma deficiência de aminoácidos essenciais na síntese de DNA e RNA, que pode levar a um considerável comprometimento do sistema imune. O objetivo do presente estudo foi avaliar a imunidade humoral e celular de crianças com desnutrição crônica moderada e grave. Estudo do tipo transversal realizado com crianças de 24 a 59 meses e 29 dias, semi-internas no Centro de Recuperação e Educação Nutricional, Maceió/AL, portadoras de desnutrição crônica. No mesmo período constituiu-se um grupo controle composto de crianças eutróficas da mesma faixa etária, selecionado aleatoriamente entre os alunos matriculados na escola de ensino fundamental da mesma comunidade. Para coleta de dados foi utilizado um questionário padronizado, aplicado aos pais ou responsáveis, abordando o histórico das crianças sobre doenças infecciosas. A avaliação da imunidade celular foi realizada através da contagem dos leucócitos e linfócitos totais, linfócitos B e T, e do teste de hipersensibilidade tardia. Para avaliar a imunidade humoral foi feita a determinação das imunoglobulinas IgA, IgG e IgM séricas, e anticorpo do tipo IgG para toxóide tetânico. O estado nutricional foi determinado pelo índice altura para idade (A/I). Na análise dos dados utilizou-se estatística paramétrica e não-paramétrica com nível de significância (p<0,05). Participaram do estudo 68 crianças, sendo 34 desnutridas crônicas e 34 eutróficas. Entre os desnutridos 56% eram do sexo masculino versus 47% dos eutróficos; o índice A/I variou de -4,61 a -2,02 nas crianças desnutridas versus -0,99 a 1,17 nas eutróficas. O histórico de infecções das vias aéreas, diarréia aguda, caxumba e coqueluche foi maior entre os desnutridos, porém não foi observada diferença estatística. O número de leucócitos e linfócitos totais foi significativamente maior nas crianças desnutridas (p = 0,00). O número de linfócitos B e T, e o teste de hipersensibilidade tardia não diferiu estatisticamente entre os dois grupos. As imunoglobulinas séricas IgA e IgG foram significativamente (p = 0,00) mais elevadas entre os desnutridos. Entre as crianças desnutridas 70,5% apresentaram diminuição de anticorpos específicos do tipo IgG para toxóide tetânico versus 41,2% das eutróficas (p = 0,01). Concluiu-se que não houve comprometimento da imunidade celular e humoral nas crianças desnutridas, porém é preciso ressaltar que o número de linfócitos T foi menor e a produção de anticorpos do tipo IgG para toxóide tetânico foi significativamente menor nas crianças desnutridas crônicas.
SILVA, Bárbara Brooklyn Timóteo Nascimento. "Aspectos imunológicos do caramujo Pomacea lineata (Spix, 1827) sob condições de estivação induzida." Universidade Federal Rural de Pernambuco, 2014. http://www.tede2.ufrpe.br:8080/tede2/handle/tede2/5039.
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Pomacea lineata (Spix, 1827) is a pulmonate gastropod that has a large dependence on humidity, Ampullaridae belongs to the family whose geographic distribution includes almost all the Neotropical Region , which inhabits waters of course slow and stagnate. Pulmonate gastropods have a conspicuous ecological feature, aestivation, which is a form of resistance and adaptation probably best defined as a survival strategy to cope with the arid conditions, but is also typically associated with lack of food availability, and often with high ambient temperatures. During these periods of aestivation some physiological aspects can be changed, as in molluscs, most of these is temperature dependent and can be altered by its variation, including the activity of the immune system. The innate immune system of invertebrates involves humoral and cellular response similar to that found in vertebrates. The cellular defenses occurs in combination with humoral defenses. Humoral responses include the production of reactive oxygen species (ROS) and nitric oxide (NO) and phenol oxidase enzyme activity, and cellular immune reactions are performed by hemocytes, performing, among other functions, encapsulation and phagocytosis of the pathogen. Thus, this research aimed to obtain information on some immunological parameters snail P. lineata in conditions of induced aestivation. The snails were induced to aestivation through the gradual withdrawal of water in the aquarium and abstention from food, getting in these conditions for 60 days. After this period, hemolymph of 40 individuals were collected for analysis of the total haemocyte count, measurement of nitric oxide, phenol oxidase activity and total protein. The results revealed that animals under aestivation showed a significant increase in the total number of hemocytes and measurement of nitric oxide, which may confer greater chance of survival.
Pomacea lineata (Spix, 1827) é um gastrópode pulmonado que apresenta uma grande dependência da umidade, pertencente à família Ampullaridae cuja distribuição geográfica inclui quase toda a Região Neotropical, na qual habita águas de curso lento e estagnadas. Gastrópodes pulmonados apresentam uma característica ecológica conspícua, a estivação, que é uma forma de resistência e adaptação provavelmente melhor definida como uma estratégia de sobrevivência para lidar com as condições áridas, mas também é tipicamente associada com a falta de disponibilidade de alimentos e, frequentemente, com as altas temperaturas ambientais. Durante estes períodos de estivação alguns aspectos fisiológicos podem ser alterados, pois nos moluscos, a maioria desses, é dependente da temperatura e podem ser alterados pela sua variação, incluindo a atividade do sistema imunitário. O sistema imunológico inato dos invertebrados envolve a resposta celular e humoral similarmente ao encontrado nos vertebrados. As defesas celulares ocorrem em combinação com as defesas humorais. As respostas humorais, incluem a produção de espécies reativas de oxigênio (ROS) e óxido nítrico (NO) e a atividade da enzima fenoloxidase, e as reações imunes celulares são realizadas pelos hemócitos, que executam, dentre outras funções, o encapsulamento e fagocitose do patógeno. Assim, esta pesquisa teve por objetivo obter informações sobre alguns parâmetros imunológicos do caramujo P. lineata em condições de estivação induzida. Os caramujos foram induzidos à estivação através da retirada gradual de água no aquário e abstenção de alimento, ficando nestas condições por 60 dias. Após este período, hemolinfa de 40 indivíduos foram coletadas para as análises de contagem total de hemócitos, dosagem de óxido nítrico, atividade da fenoloxidase e proteínas totais. Os resultados revelaram que os animais estivantes apresentavam um aumento significativo no número total de hemócitos e na dosagem de óxido nítrico, o que pode conferir maior chance de sobrevivência.
Hein, Héber Eduardo. "Influência da imunidade de matrizes suínas na resposta à vacinação de leitões contra Mycoplasma hyopneumoniae." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2015. http://hdl.handle.net/10183/127074.
Swine production is widespread in Brazil, being the fourth largest producer of pork meat. Swinesare concentrated in the Southern region, comprising 48.8%of pig population. However, due to confinement system, pigs are exposed to pathogens such as the bacteria Mycoplasma hyopneumoniae (Mhyo), responsible for swine enzootic pneumonia (SEP). The disease is characterized by a dry, nonproductive cough, and macroscopic areas of consolidation in the lung. The piglet vaccination is an important practice to SEP control. However, it is reported that passive immunity acquired by the piglets through the colostrum of sows may affect their response to vaccination against Mhyo. The objective of this study was to evaluate the influence of maternal immunity in the pig vaccination against Mhyo after weaning. Ten sows were divide in two groups according with the ELISA’s S/P Ratio, with low (LAb, S/P Ratio <0.75) or high (HAb, S/P Ratio ≥0.75) level of antibodies (Ab). From each sow, two piglets were controls (contr) and nine vaccinated (vac) against Mhyo. Piglets' humoral and cellular immunity and pulmonary lesions were compared between the treatments and groups of sows.The Ab level after colostrum intake was higher in piglets from HAb group of sows until 56 days of age. When evaluated by ELISA, LAb-vac piglets showed a more stable Ab levels from 13 to 99 days post-vaccination, with a significant increase at 113 days post-vaccination. No differences were detected between groups and treatments according with cellular parameters, except T CD4+CD8+ lymphocytes percentages, that were lower in vaccinated piglets. Regardless of the group, vaccinated pigs had lower pulmonary lesions, but the LAb-vac piglets had less damage than the HAb-vac. These results demonstrated that piglet vaccination against Mhyo at weaning protects them against the pathogen and provides lower pulmonary lesions, especially when the immunization occurs in the presence of low levels of maternal Ab.
Beattie, Lynette. "The role of the spleen in Malaria : Cellular changes that affect the development of immunity." Queensland University of Technology, 2006. http://eprints.qut.edu.au/16195/.
Silva, Milton Thiago Guerino da. "Avaliação de potencial agente vacinal contra o S.pyogenes em camundongos transgênicos, portadores de genes HLA de classe II humanos." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/5/5146/tde-20122011-155537/.
Streptococcal pharyngitis triggered by Streptococcus pyogenes throat infection can result in rheumatic fever (RF) and rheumatic heart disease (RHD) in untreated susceptible individuals. RF is an autoimmune disease that affects more than 20 million children in developing countries. M protein is the major factor of virulence of the bacteria, and it has been studied to develop a vaccine. Currently more than 200 M protein types have been described and its Cterminal domain is conserved in many different serotypes. We developed a vaccine epitope (StreptInCor) composed by 55 amino acid residues of the Cterminal portion of the M protein. In the present work we analyze the ability of the StreptInCor of induce immune response in HLA class II transgenic mice. The transgenic mice harboring the HLA Class II DR2, DR4, DQ6 and DQ8 were immunized subcutaneously with 50 g StreptInCor adsorbed onto 300 g of aluminum hydroxide gel on days 0 and 14. Control groups were immunized with vehicle (Saline) in same conditions. The sera were obtained on day 28 and tested by ELISA to verify the presence of antibodies. The specific cellular immune response was evaluated by proliferation assay using splenocytes. No cross reaction with cardiac myosin were observed. Tissue samples from immunized mice followed by 12 months were analyzed in order to verify if StreptInCor induces some histological damage. No autoimmune or deleterious reactions were observed. In conclusion our results indicate that StreptInCor Induces a good and prolonged and safe immune response in HLA class II transgenic mice
Shidani, Babak. "Effet de la cyclosporine a sur le systeme immunitaire de la souris." Paris 7, 1987. http://www.theses.fr/1987PA077159.
Reidel, Ivana. "Análisis de nuevos vehículos y adyuvantes para inmunización con antígenos de Staphylococcus aureus utilizando diferentes modelos experimentales." Thesis, Poitiers, 2020. http://www.theses.fr/2020POIT1803.
Staphylococcus aureus infections represent a major concern for human health and veterinary medicine. The excessive use of antibiotics to treat these infections has led to emergent multi-resistant strains of bacteria and encourages us to develop alternative methods for prevention such as vaccination. To date, there are no vaccines approved for use in humans and only two vaccines are used in the control of bovine mastitis, with a low efficacy. Therefore, new tools are needed to prevent infections caused by S. aureus.The objective of this thesis work is test new vaccine liposomal formulations composed of antigen from S.aureus and different immunostimulating agents including oligodesoxynucleotides (ODN)-CpG, aluminum hydroxide (Al(OH)3), gemini-type proteolipids (AG2-C16) or modified oligosaccharides (Mannan-derived molecules, OPM). The adjuvant capacities of these molecules have been tested in different animal models. In the bovine model, immunizations of calves, heifers and pregnant cows show the efficacy of liposomal formulations composed of S. aureus antigens associated with ODN-CpG, eliciting a strong humoral immune response by the production of specific IgG1 and IgG2 antibodies, able to inhibit S. aureus toxins. In the murine model, intradermal injection of vaccine formulations revealed the efficacy of the adjuvants ODN-CpG, AG2-C16 and OPM in the induction of a robust humoral response (production of specific antibodies) and the development of a cellular response involving IFN-γ-secreting T CD8+ lymphocytes which play a crucial role in the defense against intracellular bacteria. Finally, in order to study the potential of liposomal vaccines to penetrate the skin, considered as an immunization site of interest, in vitro experiments realized on reconstituted mouse epidermis have shown that the proteolipid adjuvant AG2-C16 associated with liposomes promotes their transcutaneous migration, allowing their use for topical administration. Other experiments were carried out on mouse keratinocyte and fibroblast cultures demonstrating the capacity of the oligosaccharide adjuvant OPM to stimulate fibroblast to produce proinflammatory chemokines and cytokines, leading to the development of a stronger immune response toward the vaccine.Together, the results presented in this thesis demonstrate that cationic liposomes constitute a versatile vectorization system, which allows the selection of the proper immunostimulants, depending on the needed immune response characteristics
Quiniou, Debrie Marie-Christine. "Immunité anti-ilots chez des diabétiques insulino-dépendants de type 1." Paris 6, 1986. http://www.theses.fr/1986PA066085.
Meissonnier, Guylaine. "Effets toxiques de l'aflatoxine b1 et de la toxine t-2 sur les systèmes de défenses métaboliques et immunitaires chez le porc, évaluation des effets protecteurs de glucomannanes." Toulouse 3, 2007. http://www.theses.fr/2007TOU30153.
Aflatoxin B1 (AFB1) and T-2 toxin are mycotoxins, secondary metabolites from fungi that sporadically contaminate food and feed, particularly cereals. The mains objectives of our work were to determine in pigs, a target species and highly sensitive to mycotoxin, the toxic effects of AFB1 and T-2 toxin on two defence systems, liver drug-metabolizing enzymes activities et the immune system. We also evaluate in vivo the protective effect of a potent mycotoxin binder. In pigs, AFB1 exposure for the doses investigated did not induce major clinical sign of intoxication. But, we observed lesions in liver tissue, a specific impairment of liver drug-metabolizing enzymes activities (monooxygenase cytochrome P450 dependant) and during immunization we showed a reduced cellular-mediated immune response specific for the vaccine antigen. T-2 toxin exposure did not induce any clinical sign of intoxication, or any tissue lesion in pigs. We observed a specific impairment of liver drug-metabolizing enzymes activities in liver, and during immunization T-2 toxin reduced the production of antibodies specific for the antigen. The addition of glucomannans in feed reduced the toxic effects of both mycotoxins. .
Pelletier, Lucette. "Mecanismes cellulaires impliques dans l4 autoimmunite induite par hgcl : :(2) chez le rat." Paris 6, 1987. http://www.theses.fr/1987PA066573.
Florentin, Irène. "Caracterisation fonctionnelle comparative de substances immunomodulatrices." Paris 6, 1987. http://www.theses.fr/1987PA066374.
Gougerot-Pocidalo, Marie-Anne. "Processus oxydants et reponses immunitaires : mecanismes biochimiques et cellulaires." Paris 7, 1988. http://www.theses.fr/1988PA077063.
Schmitt, Christian. "Etude de clones de lymphocytes t humains specifiques de l'anatoxine tetanique." Paris 7, 1987. http://www.theses.fr/1987PA077003.
Nohr, Carl William. "Humoral immunity in surgical patients." Thesis, McGill University, 1988. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=75969.
Cassis, Linda 1977. "Role of progranulin in humoral immunity." Doctoral thesis, Universitat Pompeu Fabra, 2015. http://hdl.handle.net/10803/398398.
El bazo humano está continuamente expuesto a antígenos provenientes de la sangre derivados de células apoptóticas autólogas y bacterias comensales. Esta estimulación crónica de la zona marginal (ZM) resulta en la generación de una respuesta de anticuerpos que se produce de forma fisiológica bajo condiciones no inflamatorias. Para evitar la inflamación continua, se requieren señales inmunorreguladoras, todavía poco conocidas. Nuestro grupo identificó una población de neutrófilos esplénicos llamada neutrófilos ayudantes de células B (células NBH)1 que contribuyen a la inducción de anticuerpos en la ZM en condiciones fisiológicas. Las células NBH expresan factores activadores de las células B y factores inmunorreguladores, incluyendo progranulina (PGRN). PGRN es una proteína antiinflamatoria altamente expresada en lugares constantemente expuestos a antígenos. Regula varios procesos, incluyendo la embriogénesis, la supervivencia neuronal, y la reparación de heridas. Sin embargo, el papel de PGRN en la respuesta inmune sigue siendo en gran medida desconocido. En este estudio demostramos que PGRN participa activamente en las respuestas pre- y post-inmunes contra antígenos microbianos en el bazo, regulando la frecuencia y / o la función de células inmunitarias innatas y adaptativas como neutrófilos, células dendríticas, células T y B. Estos hallazgos sugieren que PGRN actúa como un adyuvante endógeno que puede facilitar el desarrollo de nuevas estrategias para modular la respuesta inmunitaria protectora contra patógenos invasores.
Rydyznski, Carolyn E. "Natural Killer Cell Regulation of Humoral Immunity." University of Cincinnati / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1535377157934852.
Fayette, Jérôme. "Effet des cellules dendritiques humaines générées in vitro sur la réponse immunitaire humorale." Lyon 1, 1998. http://www.theses.fr/1998LYO1T259.
Berkeley, Robert Anthony. "Immune cell carriers and humoral immunity in oncolytic virotherapy." Thesis, University of Leeds, 2018. http://etheses.whiterose.ac.uk/20532/.
Willems, Kristen N. "Regulation of Humoral Immunity by Pim Kinases: A Dissertation." eScholarship@UMMS, 2011. https://escholarship.umassmed.edu/gsbs_diss/567.
Smith, Karen. "Cellular and humoral mechanisms of allergic disease." Thesis, University of Brighton, 2012. https://research.brighton.ac.uk/en/studentTheses/57df8daa-8006-4dff-8d44-ba39572913aa.
Rembert, Audrey. "Les vaccins antivarioliques : pathogénicité-innocuité, immunogénicité humorale et cellulaire, protection." Aix-Marseille 2, 2006. http://www.theses.fr/2006AIX20707.
Smallpox, eradicated in 1980, was one of the most dreaded infectious diseases. The threat of re-emerging variola virus induced the evaluation of new smallpox vaccines. The aim of our study was to determine immune factors induced in natural protection against orthopoxviruses and to assess new smallpox vaccines. The characterisation of the mice/cowpoxvirus rodent-like model had put in evidence the important role of all the component of the specific immune system in natural protection of mice. A second generation vaccine (2G) and tree non replicative vaccinia virus strains (3G) was evaluated in our model. The 2G smallpox vaccine showed similar vaccine efficacy than the traditional vaccine. Among the different 3G vaccines assessed, the MVA strain was the only vaccine candidate inducing a similar long-term protection than the traditional vaccine but only after a vaccine boost. However, the long-term induced MVA immunogenicity was inferior to this induced by the traditional smallpox vaccine
Shimokata, Kaoru. "Cytokines and Local Cellular Immunity." 名古屋大学医学部, 1997. http://hdl.handle.net/2237/6185.
Wendling, Daniel. "Aspects immunologiques et systemiques des spondylarthropathies." Besançon, 1991. http://www.theses.fr/1991BESA3703.
Bruns, Nicholas Joseph. "Humoral and cell-mediated immunity in vitamin A-deficient lambs." Diss., Virginia Polytechnic Institute and State University, 1988. http://hdl.handle.net/10919/53919.
Ph. D.
Sallam, Jamal A. "Intestinal humoral immunity in man : IgA and anti-salmonella antibodies." Thesis, University of Edinburgh, 1995. http://hdl.handle.net/1842/20766.
Casas, Rosaura. "Transfer of humoral immunity from the mother to her off-spring /." Linköping : Univ, 2001. http://www.bibl.liu.se/liupubl/disp/disp2001/med692s.pdf.
Wuttge, Dirk Marcus. "Cellular immunity and inflammation in atherosclerosis /." Stockholm : Karolinska Univ. Press, 2001. http://diss.kib.ki.se/2001/91-7349-051-2/.
Lucin, Kurt M. "Mechanisms of impaired humoral immunity after high thoracic spinal cord injury." Columbus, Ohio : Ohio State University, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1186411177.
Yassine, Daadaa. "Network Decontamination with Temporal Immunity." Thèse, Université d'Ottawa / University of Ottawa, 2012. http://hdl.handle.net/10393/20633.
Makedonas, George. "Cellular immunity among HIV exposed, uninfected individuals." Thesis, McGill University, 2005. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=111828.
Patel, Mihil. "Regulation of cellular immunity by human cytomegalovirus." Thesis, Cardiff University, 2018. http://orca.cf.ac.uk/114496/.
Tye, Gee Jun. "Combined adjuvant for stimulation of cellular immunity." Thesis, King's College London (University of London), 2012. https://kclpure.kcl.ac.uk/portal/en/theses/combined-adjuvant-for-stimulation-of-cellular-immunity(b1be07ae-b8d4-40a8-9258-bc3e3413df9d).html.
Titanji, Kehmia. "Mechanisms underlying impaired humoral immunity in primary and chronic HIV-1 infection /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-728-6/.
Ng, D. H. L. "Loss and recovery of humoral immunity to influenza virus following malaria infection." Thesis, University College London (University of London), 2012. http://discovery.ucl.ac.uk/1349451/.
Lownik, Joseph C. "The Role of ADAM10 and ADAM17 in Humoral and Type 2 Immunity." VCU Scholars Compass, 2018. https://scholarscompass.vcu.edu/etd/5680.
Brock, Robert W. "The initiation of remote hepatic injury, humoral and cellular mediators." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/NQ58201.pdf.
Atta, Mustafa S. "Investigation of the humoral and cellular features of autoimmune diseases." Thesis, University of Nottingham, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.281586.
Wong, Garret Drew. "Human humoral immunity to respiratory syncytial virus, correlates of disease severity and protection." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape17/PQDD_0004/MQ32975.pdf.
Majid, Amir Abdul Fattah Abdul. "Humoral immunity to melanoma antigens in patients with benign & malignant pigmented dermatoses." Thesis, University of London, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.362838.
White, Sarah Elise, and Sarah Elise White. "Can current methods of immune rejuvenation improve humoral immunity against a viral infection?" Thesis, The University of Arizona, 2017. http://hdl.handle.net/10150/626801.
Blevins, Sarah. "Characterizing Compensatory Effects of Silymarin on Gossypol Toxicosis in Lines of Chickens Divergently Selected for Humoral Immune Response." Thesis, Virginia Tech, 2009. http://hdl.handle.net/10919/34609.
Master of Science
Weber, Wilhelm Evert Jacob. "Cellular auto-immunity in central nervous system disease." Maastricht : Maastricht : Rijksuniversiteit Limburg ; University Library, Maastricht University [Host], 1988. http://arno.unimaas.nl/show.cgi?fid=5594.
Nickless, Jane Christina. "Cellular immunity to acetylcholine receptor in myasthenia gravis." Thesis, University of Bath, 1985. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.767550.
Watkins, Marcia Linda Vivienne. "Cellular immunity of naïve and BCG vaccinated neonates." Doctoral thesis, University of Cape Town, 2010. http://hdl.handle.net/11427/10984.
Includes bibliographical references (leaves 153-187).
Despite more than 95% vaccination coverage with Mycobacterium bovis Bacille Calmette-Guérin (BCG), tuberculosis (TB) remains epidemic in South Africa. The dichotomy that successful pregnancy is usually associated with a type 2 (Th2) cytokine profile in the newborn child, whereas immunity to Mycobacterium tuberculosis (Mtb) is associated with the development of a type 1 helper (Th1) cytokine response, could impact on the subsequent adaptive immune response to BCG vaccination. Previous studies have suggested that immune responses in early life may be defective and related to the immaturity of antigen-presenting cells and/or T cells.
Haque, Khawaja Mostaq Gausul. "The quantitation of cellular allo-immunity in preparation for monitoring of cellular tolerance." Thesis, University of Bristol, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.389232.
Zettervall, Carl-Johan. "Signaling pathways in the activation and proliferation of Drosophila melanogaster blood cells." Doctoral thesis, Umeå : Umeå centrum för molekylär patogenes (UCMP), 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-513.