Academic literature on the topic 'Hus{\crq}s room'

The main objective is to help physicians carry out those aspects of clinical trials described in this book. . . .Each individual involved in conducting a trial should be qualified by education, training, and experience to perform his or her respective task(s). . . . . . . —[ICH-GCP 2.8]. . . It is hardly rational to expect people to do things properly unless they are shown how, so that the importance of formal training and education for everyone involved with the pharmaceutical industry should be self-evident. The perpetuation of bad habits by those who are poorly trained and educated, whether in pharmaceutical companies or at investigator sites, is one of the root causes of the inefficiencies in drug development. Yet, while few people (whether or not they actually educate people properly) would dispute the importance of well-trained employees, it is uncommon for most companies to insist that all of those upon whom they depend are properly trained as well. Among those who are rarely trained to meet the required standards of excellence are CRO staff and investigators and their site staff. Negotiations with CROs rarely involve an assessment of how the various tasks are performed and whether or not they are carried out to the standards expected by the sponsor staff. This is not to imply that sponsor employees are better at what they do than CRO staff. What is true, however, is that sponsor employees should know how to do things the way the sponsor wants them done, which in turn should correspond to the sponsor’s notion of excellence. CROs will always profess to have all the processes requested by a sponsor, so that a laissez-faire attitude pervades negotiations. However, CROs quite understandably have their own ways of working, and unless alternatives are specified contractually, what the CRO does is what the sponsor gets. The next logical step after specifying what is wanted is to provide the necessary training for CRO staff. Where education and training are most needed and are carried out most poorly is in the case of clinical trial investigators.

Supermartensitic 13% Cr stainless steels have been in use in offshore satellite flowlines for several years. Since they contain microstructure that is susceptible to hydrogen cracking, the pick up of hydrogen in welding with subsequent transport to critical areas may be very important, also with respect to hydrogen embrittlement when hydrogen is coming from other sources than welding (e.g., cathodic protection). In the present investigation the pick up of hydrogen has been assessed using mechanized TIG welding with superduplex 25% Cr wire. The WM and HAZ hydrogen levels were analyzed. With add

Abstract Rotating machinery relies on engineered tilting-pad journal bearings (TPJB) to provide static load support with minimal drag power losses, safe pad temperatures, and ensuring a rotordynamic stable rotor operation. End users focus on reducing the supplied oil flow rate into a bearing to both lower operational costs and to increase drive power efficiency. This paper presents measurements of the steady-state and dynamic forced performance of a TPJB whilst focusing on the influence of supplied oil flow rate, below and above a nominal condition (50% and 150%). The test bearing has five pad