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Dissertations / Theses on the topic 'Hyaluronate receptor'

Author: Grafiati

Published: 4 June 2025

Last updated: 1 August 2025

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1

Ghazi, Kamelia. "Etude et modulation du microenvironnement des purinorécepteurs de mort P2X7 par des formulations lipidiques et biopolymères afin de réguler les mécanismes de prolifération et de dégénérescence cellulaire sur des modèles dermatologiques : cicatrisation et mélanome." Thesis, Paris 5, 2012. http://www.theses.fr/2012PA05P655/document.

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Le purinorécepteur P2X7 joue un rôle majeur dans les phénomènes de dégénérescences (Alzheimer, DMLA) et mort cellulaires. Récemment des études ont montré que l’activation basale de ce récepteur est indispensable dans le processus de cicatrisation et de prolifération cellulaire. Nous avons essayé de mieux comprendre le paradoxe de cette activation du récepteur P2X7 qui oriente vers la prolifération et même les métastases tumorales, mais aussi vers les mécanismes de dégénérescence cellulaire. L'influence du microenvironnement (Lipides, matrice extracellulaire, oxygène) apparait essentielle pour

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2

Tzircotis, George. "Regulation of the hyaluronan receptor CD44 by phosphorylation." Thesis, Institute of Cancer Research (University Of London), 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.416883.

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3

Prevo, Remko. "Characterisation of new Link superfamily Hyaluronan receptors." Thesis, University of Oxford, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.275401.

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4

Wang, Chao. "The role of hyaluronan receptor RHAMM in breast carcinoma." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape10/PQDD_0004/NQ41526.pdf.

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5

Nightingale, Thomas. "Regulated ligand binding of LYVE-1 : a lymphatic endothelium specific hyaluronan receptor." Thesis, University of Oxford, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.409119.

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6

Buttermore, Stephanie T. "The Role of Elevated Hyaluronan-Mediated Motility Receptor (RHAMM/HMMR) in Ovarian Cancer." Scholar Commons, 2017. http://scholarcommons.usf.edu/etd/6808.

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Ovarian cancer (OC) has the highest mortality among gynecological cancers. The high mortality is associated with the lack of an accurate screening tool to detect disease in early stage. As a result the majority of OCs are diagnosed in late stage. Further, the molecular events responsible for malignant transformation in the ovary remain poorly understood. Consequently, delineating key molecular players driving OC could help elucidate potential diagnostic, prognostic and therapeutic targets. Receptor for hyaluronan-mediated motility (RHAMM) belongs to a group of hyaladherins,

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7

Messaritou, Georgia. "The role of the hyaluronan receptor CD44 in the regulation of matrix metalloproteinase." Thesis, Imperial College London, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.416377.

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8

Rodriguez-Hurtado, Isabel Stewart Allison Jean. "The presence of the hyaluronan receptor CD44 in the reproductive tract of the mare." Auburn, Ala., 2007. http://hdl.handle.net/10415/1333.

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9

Allison, Patrick Bartlett. "Src Kinase Regulates TGFβ And Hyaluronan Induced Epicardial Cell Invasion, Differentiation And Migration". Diss., The University of Arizona, 2014. http://hdl.handle.net/10150/347226.

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The development of the mature cardiovascular system is one of the most captivating stories in embryonic development. The heart is the first organ to form in embryogenesis, and is functional early in development to perfuse the embryo with blood supplying oxygen and the nutrients required for organogenesis. The structural changes in heart development required for formation of the mature four chambered heart are under tight molecular regulation. Severe defects manifest as gross structural malformations of the valves, septa, or vessels that result in physiological consequences that my include hype

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10

Hintze, Vera, Sergey Samsonov, Sandra Rother та ін. "Sulfated Hyaluronan Derivatives Modulate TGF-β1:Receptor Complex Formation: Possible Consequences for TGF-β1 Signaling". Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2017. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-230329.

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Glycosaminoglycans are known to bind biological mediators thereby modulating their biological activity. Sulfated hyaluronans (sHA) were reported to strongly interact with transforming growth factor (TGF)-β1 leading to impaired bioactivity in fibroblasts. The underlying mechanism is not fully elucidated yet. Examining the interaction of all components of the TGF-β1:receptor complex with sHA by surface plasmon resonance, we could show that highly sulfated HA (sHA3) blocks binding of TGF-β1 to its TGF-β receptor-I (TβR-I) and -II (TβR-II). However, sequential addition of sHA3 to the TβR-II/TGF-β1

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11

Hide, Branwen Rainbow-Star. "Structural and functional analysis of the lymphatic vessel endothelial receptor (LYVE-1) hyaluronan binding domain." Thesis, University of Oxford, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.531822.

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12

Legg, James William. "Regulation of the hyaluronan receptor CD44 by the ezrin/radixin/moesin (ERM) family of proteins." Thesis, Imperial College London, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.392688.

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13

Al-Baradie, Raid Saleem. "The role of hyaluronan in angiogenesis through RHAMM and CD44 receptors in endothelial cells." Thesis, University of Manchester, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.516733.

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Oligosaccharides of hyaluronan (o-HA; 3-10 disaccharides) are pro-angiogenic and are believed to act through two receptors, C044 and RHAMM (receptor for hyluronanmediated motility). Utilizing human liver micro-vessel-derived endothelial cells (HLMVEC)and bovine aortic endothelial cells (BAEC), the roles of C044 and RHAMM in o-HA induced signalling were examined. In vitro assays were employed for proliferation, migration and tube formati~m by endothelial cells, prior to and following C044 and RHAMM knock-down, using small interference RNA (siRNA) technology. Epidermal growth factor (EGF), which

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14

Shah, Kush. "Receptor-Mediated Targeting to Enhance Therapeutic Efficacy of Chemotherapeutic Agents." University of Akron / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=akron1390926627.

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15

Hellström, Martin. "Hyaluronan and the receptor CD 44 in the heart and vessels : a study in normal and pathological conditions." Doctoral thesis, Umeå universitet, Medicin, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1128.

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Tissues are not solely composed of cells. The extracellular matrix is important for the cell well-being and cell-cell communication. The glycosaminoglycan hyaluronan (HYA) is a widely distributed extracellular matrix (ECM) component. The molecule has prominent physicochemical properties, foremost viscoelastic and osmotic, but participates in many biological processes such as cell migration, proliferation, tissue turnover, wound healing and angiogenesis. HYA is synthesised by either of three different hyaluronan-synthesising enzymes, HAS1-3, and its main ligand is the transmembrane receptor CD4

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16

Hellström, Martin. "Hyaluronan and the receptor CD 44 in the heart and vessels : a study in normal and pathological conditions /." Umeå : Univ, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1128.

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17

Milana, Kresoja Ignjatović. "Клинички значај идентификације туморских матичних ћелија у ткиву аденокарцинома колона". Phd thesis, Univerzitet u Novom Sadu, Medicinski fakultet u Novom Sadu, 2020. https://www.cris.uns.ac.rs/record.jsf?recordId=114944&source=NDLTD&language=en.

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Karcinom debelog creva predstavlja treći uzrok smrnosti od maligniteta kod mu&scaron;karaca i drugi kod žena. Postoji osnovana sumnja da kancerske matične ćelije (KMĆ) imaju veliki značaj u karcinogenezi, invazivnosti, &scaron;irenju i rezistenciji na hemioterapiju primarnog tumora. Njihova identifikacija u primatnom kolorektalnom karcinomu (KRK) putem markera kancerskih matičnih ćelija bi selektovala visokorizičnu grupu bolesnika, omogućila ciljano delovanje na ove ćelije i veću &scaron;ansu za izlečenje. Cilj ovog istraživanja je bio utvrđivanje uticaja prisustva kancerskih matičnih ćelija u

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18

Siponen, M. (Maria). "Oral lichen planus – etiopathogenesis and management." Doctoral thesis, Oulun yliopisto, 2017. http://urn.fi/urn:isbn:9789526214702.

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Abstract Oral lichen planus (OLP) is a chronic immune-mediated mucosal disease with unknown etiology. According to the current view, the pathogenesis of OLP involves activation of T-cell mediated immunity against the epithelial keratinocytes. A proportion of OLP patients are affected by painful symptoms, and the risk of oral cancer is increased in OLP. There is no curative treatment for OLP. Topical corticosteroids are used most commonly in the management of OLP. However, the evidence base for the effectiveness of any therapy is weak. The objective of this thesis was to study novel aspects of

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19

Sapudom, Jiranuwat, Franziska Ullm, Steve Martin, et al. "Molecular weight specific impact of soluble and immobilized hyaluronan on CD44 expressing melanoma cells in 3D collagen matrices." 2017. https://ul.qucosa.de/id/qucosa%3A33113.

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Hyaluronan (HA) and its principal receptor CD44 are known to be involved in regulating tumor cell dissemination and metastasis. It is hypothesized that the CD44-HA interaction regulates proliferation and invasion of tumor cells in dependence on the molecular weight and the presentation form of HA. To address this hypothesis, we reconstituted 3D collagen (Coll I) matrices and functionalized them with HA of molecular weight of 30-50 kDa (low molecular weight; LMW-HA) and 500-750 kDa (high molecular weight; HMW-HA). A post-modification strategy was applied to covalently immobilize HA to reconstit

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20

Μπούγα, Ελένη. "Ένζυμα μεταβολισμού του υαλουρονικού οξέος στον καρκίνο του παχέος εντέρου". Thesis, 2007. http://nemertes.lis.upatras.gr/jspui/handle/10889/757.

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Ο καρκίνος του παχέος εντέρου αποτελεί αναμφισβήτητα ένα παγκόσμιο πρόβλημα, όντας η δεύτερη αιτία θανάτου από καρκίνο. Τα γεγονότα που οδηγούν σε καρκίνο του παχέος εντέρου ακολουθούν στις περισσότερες περιπτώσεις συγκεκριμένη αλληλουχία. Έτσι, ξεκινώντας από υπερπλαστικό επιθήλιο, εξελίσσεται σε αδένωμα/δυσπλασία, σε ενδοεπιθηλιακή νεοπλασία και καταλήγει σε καρκίνο. Κατά την εξέλιξη σε καρκίνο σημαντικές αλλαγές λαμβάνουν χώρα στη σύσταση και οργάνωση του εξωκυττάριου χώρου του εντερικού τοιχώματος. Για το λόγο αυτό απαιτείται μελέτη του μεταβολισμού των εξωκυττάριων μακρομοριακών συστατικώ

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21

Ulbrich, Susanne Ernestine [Verfasser]. "Importance of steroid hormone receptors, nitric oxide synthesis and hyaluronan turnover for the control of oviduct function / Susanne Ernestine Ulbrich." 2005. http://d-nb.info/977837246/34.

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22

Köhler, Linda. "Interaction of glycosaminoglycans with growth factors and their receptors – implications for biological activity." Doctoral thesis, 2018. https://tud.qucosa.de/id/qucosa%3A32521.

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Die aufgrund des demografischen Wandels steigende Zahl an Patienten mit Knochendefekten, chronischen Wunden und einhergehender Multimorbidität stellt ein großes klinisches und sozioökonomisches Problem dar. Derzeitige etablierte Verfahren zur Behandlung von Knochen- und Hautdefekten weisen zahlreiche Nachteile auf, weshalb die Erforschung innovativer Methoden notwendig ist. Ein vielversprechender Ansatz zur Verbesserung der Wundheilungskapazität ist die Funktionalisierung von Biomaterialien mit Komponenten der extrazellulären Matrix (ECM), die eine Rolle bei der Geweberegeneration spielen. Gly

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