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Journal articles on the topic 'Hyaluronate receptor'

Author: Grafiati

Published: 4 June 2025

Last updated: 1 August 2025

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1

Green, S. J., G. Tarone, and C. B. Underhill. "Distribution of hyaluronate and hyaluronate receptors in the adult lung." Journal of Cell Science 90, no. 1 (1988): 145–56. http://dx.doi.org/10.1242/jcs.90.1.145.

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In the present study, we have examined the distribution of both hyaluronate receptors and hyaluronate in adult hamster lung. The receptor for hyaluronate is a transmembrane glycoprotein of Mr 85,000 that interacts with actin filaments and is thought to mediate many of the effects that hyaluronate has on cell behaviour, such as cell-to-cell adhesion and migration. It was localized histochemically with a monoclonal antibody, designated as K-3, which specifically binds to the receptor. Hyaluronate was detected by a biotinylated form of cartilage proteoglycan, which binds with high affinity and sp

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2

Alho, A. M., and C. B. Underhill. "The hyaluronate receptor is preferentially expressed on proliferating epithelial cells." Journal of Cell Biology 108, no. 4 (1989): 1557–65. http://dx.doi.org/10.1083/jcb.108.4.1557.

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In the present study, we have examined the distribution of the hyaluronate receptor as well as hyaluronate itself in a variety of adult tissues. The hyaluronate receptor was localized with a monoclonal antibody, termed K-3, while hyaluronate was localized using proteolytic fragments of cartilage proteoglycan. Staining with the K-3 monoclonal antibody revealed that the hyaluronate receptor was present in a variety of epithelia including the skin, cheek, tongue, esophagus, vagina, intestines, oviduct, and bladder. However, it was notably absent from epithelial cells of the cornea and stomach as

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3

ARUFFO, Alejandro, and Ivan STAMENKOVIC. "The Hyaluronate Receptor (CD44)." Trends in Glycoscience and Glycotechnology 3, no. 13 (1991): 334–42. http://dx.doi.org/10.4052/tigg.3.334.

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4

Laurent, T. C., J. R. E. Fraser, H. Pertoft, and B. Smedsrød. "Binding of hyaluronate and chondroitin sulphate to liver endothelial cells." Biochemical Journal 234, no. 3 (1986): 653–58. http://dx.doi.org/10.1042/bj2340653.

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Hyaluronate is taken up and metabolized in liver endothelial cells by means of a receptor. To characterize the interaction with the receptor, two preparations of 3H-labelled hyaluronate, of Mr 4 × 10(5) and 6.4 × 10(6), and a series of hyaluronate oligosaccharides were bound to cultured liver endothelial cells at 7 degrees C. The dissociation constant varied between 4.6 × 10(-6) M for an octasaccharide and 9 × 10(-12) M for the largest polymer. The Mr-dependence for the series of oligosaccharides was explained by the increased probability of binding due to the repetitive sequence along the cha

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5

Lacy, B. E., and C. B. Underhill. "The hyaluronate receptor is associated with actin filaments." Journal of Cell Biology 105, no. 3 (1987): 1395–404. http://dx.doi.org/10.1083/jcb.105.3.1395.

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The cell-surface receptor for hyaluronate is an integral membrane glycoprotein of Mr 85,000 (Underhill, C. B., A. L. Thurn, and B. E. Lacy, 1985, J. Biol. Chem., 260:8128-8133) that is thought to mediate many of the effects that hyaluronate has on cell behavior, such as migration, angiogenesis, and phagocytosis. To determine if the receptor is associated with the underlying cytoskeleton, Swiss 3T3 cells were extracted with a solution of Triton X-100, which solubilized most of the cellular components, but which left behind an insoluble residue containing the cytoskeleton. This detergent-insolub

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6

Klewes, L., E. A. Turley, and P. Prehm. "The hyaluronate synthase from a eukaryotic cell line." Biochemical Journal 290, no. 3 (1993): 791–95. http://dx.doi.org/10.1042/bj2900791.

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The hyaluronate synthase complex was identified in plasma membranes from B6 cells. It contained two subunits of molecular masses 52 kDa and 60 kDa which bound the precursor UDP-GlcA in digitonin solution and partitioned into the aqueous phase, together with nascent hyaluronate upon Triton X-114 phase separation. The 52 kDa protein cross-reacted with poly- and monoclonal antibodies raised against the streptococcal hyaluronate synthase and the 60 kDa protein was recognized by monoclonal antibodies raised against a hyaluronate receptor. The 52 kDa protein was purified to homogeneity by affinity c

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7

Gigant‐Huselstein, C., P. Hubert, D. Dumas, et al. "Expression of adhesion molecules and collagen on rat chondrocyte seeded into alginate and hyaluronate based 3D biosystems. Influence of mechanical stresses." Biorheology: The Official Journal of the International Society of Biorheology 41, no. 3-4 (2004): 423–31. http://dx.doi.org/10.1177/0006355x2004041003004031.

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Chondrocytes use mechanical signals, via interactions with their environment, to synthesize an extracellular matrix capable to withstanding high loads. Most chondrocyte–matrix interactions are mediated via transmembrane receptors such as integrins or non‐integrins receptors (i.e. annexin V and CD44). The aim of this study was to analyze, by flow cytometry, the adhesion molecules (α5/β1 integrins and CD44) on rat chondrocytes seeded into 3D biosystem made of alginate and hyaluronate. These biosystems were submitted to mechanical stress by knocking the biosystems between them for 48 hours. The e

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8

Khaldoyanidi, Sophia, Jürgen Moll, Svetlana Karakhanova, Peter Herrlich та Helmut Ponta. "Hyaluronate-Enhanced Hematopoiesis: Two Different Receptors Trigger the Release of Interleukin-1β and Interleukin-6 From Bone Marrow Macrophages". Blood 94, № 3 (1999): 940–49. http://dx.doi.org/10.1182/blood.v94.3.940.415k27_940_949.

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The glycosaminoglycan hyaluronate (HA) is part of the extracellular environment in bone marrow. We show here that HA activates signal transduction cascades important for hemopoiesis. In myeloid and lymphoid long-term bone marrow cultures (LTBMC), treatment with hyaluronidase (HA’ase) results in reduced production of both progenitor and mature cells. Exogeneous HA added to LTBMC had the opposite effect: it enhanced hematopoiesis. The effect of HA is mediated through two different HA receptors on bone marrow macrophage-like cells, one of which is CD44 while the other is unknown. HA induces bone

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9

Thomas, L., H. R. Byers, J. Vink, and I. Stamenkovic. "CD44H regulates tumor cell migration on hyaluronate-coated substrate." Journal of Cell Biology 118, no. 4 (1992): 971–77. http://dx.doi.org/10.1083/jcb.118.4.971.

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CD44 is a broadly distributed cell surface glycoprotein expressed in different isoforms in various tissues and cell lines. One of two recently characterized human isoforms, CD44H, is a cell surface receptor for hyaluronate, suggesting a role in the regulation of cell-cell and cell-substrate interactions as well as of cell migration. While CD44H has been shown to mediate cell adhesion, direct demonstration that CD44H expression promotes cell motility has been lacking. In this work we show that a human melanoma cell line, stably transfected with CD44H, displays enhanced motility on hyaluronate-c

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10

Weiss, Johannes M., Andreas C. Renkl, Thomas Ahrens, et al. "Activation-Dependent Modulation of Hyaluronate-Receptor Expression and of Hyaluronate-Avidity by Human Monocytes." Journal of Investigative Dermatology 111, no. 2 (1998): 227–32. http://dx.doi.org/10.1046/j.1523-1747.1998.00286.x.

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11

Pawlak, Agnieszka S., Elizabeth Hammond, Thomas Hammond, and Steven D. Gray. "Immunocytochemical Study of Proteoglycans in Vocal Folds." Annals of Otology, Rhinology & Laryngology 105, no. 1 (1996): 6–11. http://dx.doi.org/10.1177/000348949610500102.

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We evaluated the proteoglycan composition of normal vocal folds using immunocytochemical techniques. Frozen sections of 14 normal cadaveric vocal folds were obtained within 12 hours of death and sectioned immediately. Vocal fold sections were stained with antibodies against keratan sulfate, chondroitin sulfate, heparan sulfate proteoglycan (HSPG), decorin, and hyaluronate receptor. We found that the lamina propria has diffuse staining of fibrillar components with keratan sulfate and decorin. Intense staining was observed in the vocal ligament area with keratan sulfate. The HSPG was localized t

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12

Sy, M. S., Y. J. Guo, and I. Stamenkovic. "Inhibition of tumor growth in vivo with a soluble CD44-immunoglobulin fusion protein." Journal of Experimental Medicine 176, no. 2 (1992): 623–27. http://dx.doi.org/10.1084/jem.176.2.623.

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CD44H is the principal cell surface receptor for hyaluronate, which is a major glycosaminoglycan of the extracellular matrix. Expression of CD44H is enhanced in a variety of malignant tumors and correlates with tumor aggressiveness, supporting the notion that interaction between CD44H and hyaluronate may play an important role in tumor growth and dissemination. In this report we show that in vivo tumor formation by human lymphoma Namalwa cells, stably transfected with CD44H, can be suppressed by a soluble human CD44H-immunoglobulin fusion protein. Disruption of the interaction between CD44H an

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13

Aruffo, Alejandro, Ivan Stamenkovic, Michael Melnick, Charles B. Underhill, and Brian Seed. "CD44 is the principal cell surface receptor for hyaluronate." Cell 61, no. 7 (1990): 1303–13. http://dx.doi.org/10.1016/0092-8674(90)90694-a.

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14

Zerrillo, Luana, Maria Rosa Gigliobianco, Domenico D’Atri, et al. "PLGA Nanoparticles Grafted with Hyaluronic Acid to Improve Site-Specificity and Drug Dose Delivery in Osteoarthritis Nanotherapy." Nanomaterials 12, no. 13 (2022): 2248. http://dx.doi.org/10.3390/nano12132248.

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Nanoparticles (NPs) have a tremendous potential in medicinal applications, and recent studies have pushed the boundaries in nanotherapy, including in osteoarthritis treatments. The aim of this study was to develop new poly(lactide-co-glycolide) (PLGA) nanoparticles (NPs) surfaces decorated with hyaluronic acid (HA) to enhance targeted drug specificity to the osteoarthritic knee joint. HA was selected since it binds to specific receptors expressed in many cells, such as the cluster determinant 44 (CD44), a major receptor of chondrocytes, and because of its function in the synovial fluid (SF), s

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15

Yazdani, Mazyar, Aboulghassem Shahdadfar, Catherine Joan Jackson, and Tor Paaske Utheim. "Hyaluronan-Based Hydrogel Scaffolds for Limbal Stem Cell Transplantation: A Review." Cells 8, no. 3 (2019): 245. http://dx.doi.org/10.3390/cells8030245.

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Hyaluronan (HA), also termed hyaluronic acid or hyaluronate, is a major component of the extracellular matrix. This non-sulfated glycosaminoglycan plays a key role in cell proliferation, growth, survival, polarization, and differentiation. The diverse biological roles of HA are linked to the combination of HA’s physicochemical properties and HA-binding proteins. These unique characteristics have encouraged the application of HA-based hydrogel scaffolds for stem cell-based therapy, a successful method in the treatment of limbal stem cell deficiency (LSCD). This condition occurs following direct

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16

Hofmann, M., C. Fieber, V. Assmann, et al. "Identification of IHABP, a 95 kDa intracellular hyaluronate binding protein." Journal of Cell Science 111, no. 12 (1998): 1673–84. http://dx.doi.org/10.1242/jcs.111.12.1673.

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The extracellular matrix component hyaluronan is believed to play important roles in various processes of organogenesis, cell migration and cancer. Recognition of and binding to hyaluronan is mediated by cell surface receptors. Three of them, CD44, ICAM-1 and RHAMM (receptor for hyaluronic acid mediated motility), have been identified. A cDNA clone designated RHAMM turned out to possess transforming capacity. Based on this published sequence, we isolated the complete cDNA of the murine gene. The cDNA comprises an open reading frame of 2.3 kb and encodes a 95 kDa protein. The protein carries a

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17

Urashima, Sachio, Mikihiro Tsutsumi, Kazuaki Ozaki, et al. "Immunohistochemical Study of Hyaluronate Receptor (CD44) in Alcoholic Liver Disease." Alcoholism: Clinical and Experimental Research 24 (April 2000): 34S—38S. http://dx.doi.org/10.1111/j.1530-0277.2000.tb00009.x.

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18

Goebeler, M., D. Kaufmann, E. B. Brocker, and C. E. Klein. "Migration of highly aggressive melanoma cells on hyaluronic acid is associated with functional changes, increased turnover and shedding of CD44 receptors." Journal of Cell Science 109, no. 7 (1996): 1957–64. http://dx.doi.org/10.1242/jcs.109.7.1957.

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Recent evidence indicates that CD44, a multifunctional adhesion receptor involved in cell-cell as well as in cell-matrix interactions, plays an important role in local progression and metastasis of malignant tumors. We have studied a set of human melanoma cell lines differing in their metastatic potential in nude mice as well as in normal melanocytes for changes in CD44 expression and function. All melanocytes and melanoma cell lines tested highly expressed the CD44 standard form (CD44s, 85 kDa) but variants at low levels only. With respect to one of the CD44-associated functions primarily inv

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19

Bhattacharya, Dipsikha. "Development of hyaluronate tethered magnetic nanoparticlesfor targeted anti-cancer drug delivery." Zastita Materijala 65, no. 1 (2024): 63–72. http://dx.doi.org/10.62638/zasmat1041.

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Despite the tremendous progress in understanding the molecular basis of the disease, cancer still remains one of the leading causes of deaths. Recently, advances in nanotechnology are rapidly enabling the development of novel, multifunctional materials with combined cancer specific targeting, therapeutic and diagnostic functions within a single nanocomplex (NP) that address the shortcomings of traditional disease diagnostic and therapeutic agents. Among the myriad of nanocarriers, magnetic nanoparticles (MNPs) have sparked extensive promise as novel theranostic applications as these MNPs can b

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20

Pouyani, Tara, and Glenn D. Prestwich. "Biotinylated Hyaluronic Acid: A New Tool for Probing Hyaluronate-Receptor Interactions." Bioconjugate Chemistry 5, no. 4 (1994): 370–72. http://dx.doi.org/10.1021/bc00028a015.

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21

Alaish, Samuel M., Dorne Yager, Robert F. Diegelmann, and I. Kelman Cohen. "Biology of fetal wound healing: Hyaluronate receptor expression in fetal fibroblasts." Journal of Pediatric Surgery 29, no. 8 (1994): 1040–43. http://dx.doi.org/10.1016/0022-3468(94)90275-5.

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22

Manstein, Carl H. "Biology of fetal wound healing: Hyaluronate receptor expression in fetal fibroblasts." Plastic & Reconstructive Surgery 97, Supplement (1996): 1092. http://dx.doi.org/10.1097/00006534-199604001-00063.

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23

Yamakage, A., H. Tabata, S. Ohtsuka, E. Yoshizawa, and S. Yamazaki. "Upregulation of the receptor for hyaluronate (CD 44) in systemic sclerosis." Journal of Dermatological Science 8, no. 1 (1994): 75. http://dx.doi.org/10.1016/0923-1811(94)90447-2.

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24

Lee, T. H., H. G. Wisniewski, and J. Vilcek. "A novel secretory tumor necrosis factor-inducible protein (TSG-6) is a member of the family of hyaluronate binding proteins, closely related to the adhesion receptor CD44." Journal of Cell Biology 116, no. 2 (1992): 545–57. http://dx.doi.org/10.1083/jcb.116.2.545.

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TSG-6 cDNA was isolated by differential screening of a lambda cDNA library prepared from tumor necrosis factor (TNF)-treated human diploid FS-4 fibroblasts. We show that TSG-6 mRNA was not detectable in untreated cells, but became readily induced by TNF in normal human fibroblast lines and in peripheral blood mononuclear cells. In contrast, TSG-6 mRNA was undetectable in either control or TNF-treated human vascular endothelial cells and a variety of tumor-derived or virus-transformed cell lines. The sequence of full-length TSG-6 cDNA revealed one major open reading frame predicting a polypepti

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Lee, Eunsol, Jaeduk Park, Yu Seok Youn, Kyung Taek Oh, Dongin Kim, and Eun Seong Lee. "Alendronate/cRGD-Decorated Ultrafine Hyaluronate Dot Targeting Bone Metastasis." Biomedicines 8, no. 11 (2020): 492. http://dx.doi.org/10.3390/biomedicines8110492.

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In this study, we report the hyaluronate dot (dHA) with multiligand targeting ability and a photosensitizing antitumor model drug for treating metastatic bone tumors. Here, the dHA was chemically conjugated with alendronate (ALN, as a specific ligand to bone), cyclic arginine-glycine-aspartic acid (cRGD, as a specific ligand to tumor integrin αvβ3), and photosensitizing chlorin e6 (Ce6, for photodynamic tumor therapy), denoted as (ALN/cRGD)@dHA-Ce6. These dots thus prepared (≈10 nm in diameter) enabled extensive cellular interactions such as hyaluronate (HA)-mediated CD44 receptor binding, ALN

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Lee, Hwiwon, Beom-Ju Hong, Jeong Ho Lee, et al. "Hyaluronate–Death Receptor 5 Antibody Conjugates for Targeted Treatment of Liver Metastasis." Biomacromolecules 17, no. 9 (2016): 3085–93. http://dx.doi.org/10.1021/acs.biomac.6b01022.

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27

Alldinger, S., S. Fonfara, E. Kremmer, and W. Baumgärtner. "Up-regulation of the hyaluronate receptor CD44 in canine distemper demyelinated plaques." Acta Neuropathologica 99, no. 2 (2000): 138–46. http://dx.doi.org/10.1007/pl00007417.

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28

DeGrendele, H. C., P. Estess, L. J. Picker, and M. H. Siegelman. "CD44 and its ligand hyaluronate mediate rolling under physiologic flow: a novel lymphocyte-endothelial cell primary adhesion pathway." Journal of Experimental Medicine 183, no. 3 (1996): 1119–30. http://dx.doi.org/10.1084/jem.183.3.1119.

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The extravasation of leukocytes from the blood into tissues occurs as a multistep process: an initial transient interaction ("rolling"), generally thought to be mediated by the selectin family of adhesion molecules, followed by firm adhesion, usually mediated by integrins. Using a parallel plate flow chamber designed to approximate physiologic flow in postcapillary venules, we have characterized a rolling interaction between lymphoid cells and adherent primary and cultured endothelial cells that is not selectin mediated. Studies using blocking monoclonal antibodies indicate that this novel int

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Puré, E., R. L. Camp, D. Peritt, R. A. Panettieri, A. L. Lazaar, and S. Nayak. "Defective phosphorylation and hyaluronate binding of CD44 with point mutations in the cytoplasmic domain." Journal of Experimental Medicine 181, no. 1 (1995): 55–62. http://dx.doi.org/10.1084/jem.181.1.55.

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CD44 is a cell surface adhesion molecule that plays a role in leukocyte extravasation, leukopoiesis, T lymphocyte activation, and tumor metastasis. The principal known ligand for CD44 is the glycosaminoglycan hyaluronate, (HA), a major constituent of extracellular matrices. CD44 expression is required but is not sufficient to confer cellular adhesion to HA, suggesting that the adhesion function of the receptor is regulated. We recently demonstrated that CD44 in primary leukocytes is phosphorylated in a cell type- and activation state-dependent fashion. In this study we demonstrate that serines

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30

Green, Shawn J., Guido Tarone, and Charles B. Underhill. "Aggregation of macrophages and fibroblasts is inhibited by a monoclonal antibody to the hyaluronate receptor." Experimental Cell Research 178, no. 2 (1988): 224–32. http://dx.doi.org/10.1016/0014-4827(88)90393-x.

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Hébert, Eric. "Endogenous Lectins as Cell Surface Transducers." Bioscience Reports 20, no. 4 (2000): 213–37. http://dx.doi.org/10.1023/a:1026484722248.

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Interactions between cells or between cell and substratum involve specificreceptors and their ligands. Among the various cell surface receptorsidentified during the last decades, the carbohydrate-binding proteins, e.g., lectins are of peculiar interest because glycolipids, glycoproteinsand proteoglycans have been shown to interact with lectins on the surfaceof animal cells. Animal lectins are recognized as molecules playingimportant roles in a variety of biological processes through binding toglycoconjugates and lectin-like receptors such as selectins, sialoadhesins(CD22, CD33), natural killer

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Soilu-Hänninen, Merja, Mikko Laaksonen та Arno Hänninen. "Hyaluronate receptor (CD44) and integrin α4 (CD49d) are up-regulated on T cells during MS relapses". Journal of Neuroimmunology 166, № 1-2 (2005): 189–92. http://dx.doi.org/10.1016/j.jneuroim.2005.05.008.

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Chen, Lu, Claus Cursiefen, Stefano Barabino, Qiang Zhang, and M. Reza Dana. "Novel Expression and Characterization of Lymphatic Vessel Endothelial Hyaluronate Receptor 1 (LYVE-1) by Conjunctival Cells." Investigative Opthalmology & Visual Science 46, no. 12 (2005): 4536. http://dx.doi.org/10.1167/iovs.05-0975.

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Herault, Olivier, Nathalie Gallay, Jorge Domenech, Philippe Colombat, and Christian Binet. "The Extramedullar Dissemination of Acute Myeloid Leukemic Cells Depends on CD31 (PECAM-1) and CD38 Coexpression Level." Blood 108, no. 11 (2006): 1896. http://dx.doi.org/10.1182/blood.v108.11.1896.1896.

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Abstract The number of peripheral white blood cells (WBC) shows a wide range in acute myeloblastic leukemia (AML) patients. A high WBC count constitutes an adverse prognosis factor when at presentation and (myelo)monocytic subtypes were more frequently associated with extramedullar tumor sites. Marrow endothelial cells express CD31 and CD31/CD31 interaction is known to promote the migration in physiological mechanisms, as for example transendothelial migration of neutrophiles and monocytes in diapedesis. CD31 is a specific receptor of CD38 which is associated with numerous molecules on the sur

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Nakamura, Hiroaki, Shin-ichi Kenmotsu, Hideo Sakai, and Hidehiro Ozawa. "Localization of CD44, the hyaluronate receptor, on the plasma membrane of osteocytes and osteoclasts in rat tibiae." Cell and Tissue Research 280, no. 2 (1995): 225–33. http://dx.doi.org/10.1007/s004410050348.

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Nakamura, Hiroaki, Shin-ichi Kenmotsu, Hideo Sakai, and Hidehiro Ozawa. "Localization of CD44, the hyaluronate receptor; on the plasma membrane of osteocytes and osteoclasts in rat tibiae." Cell and Tissue Research 280, no. 2 (1995): 225–33. http://dx.doi.org/10.1007/bf00307793.

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Fnu, Gulimirerouzi, Palak Agrawal, Gopal C. Kundu, and Georg F. Weber. "Structural Constraint of Osteopontin Facilitates Efficient Binding to CD44." Biomolecules 11, no. 6 (2021): 813. http://dx.doi.org/10.3390/biom11060813.

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Since the original description in 1996, the interaction between the cytokine osteopontin (OPN) and the homing receptor CD44 has been extensively studied in cancer, inflammation, bone remodeling, and various other conditions. Alternative splicing and extensive posttranslational modifications by both binding partners, as well as the possibility for lateral recruitment of additional membrane receptors or soluble co-ligands into a complex have left the exact molecular requirements for high-affinity OPN-CD44 binding unresolved. We now report that there is a moderate engagement between the unmodifie

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Wegener, Kate L., Jaswir Basran, Clive R. Bagshaw, et al. "Structural Basis for the Interaction between the Cytoplasmic Domain of the Hyaluronate Receptor Layilin and the Talin F3 Subdomain." Journal of Molecular Biology 382, no. 1 (2008): 112–26. http://dx.doi.org/10.1016/j.jmb.2008.06.087.

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Kriehuber, Ernst, Silvana Breiteneder-Geleff, Marion Groeger, et al. "Isolation and Characterization of Dermal Lymphatic and Blood Endothelial Cells Reveal Stable and Functionally Specialized Cell Lineages." Journal of Experimental Medicine 194, no. 6 (2001): 797–808. http://dx.doi.org/10.1084/jem.194.6.797.

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A plexus of lymphatic vessels guides interstitial fluid, passenger leukocytes, and tumor cells toward regional lymph nodes. Microvascular endothelial cells (ECs) of lymph channels (LECs) are difficult to distinguish from those of blood vessels (BECs) because both express a similar set of markers, such as CD31, CD34, podocalyxin, von Willebrand factor (vWF), etc. Analysis of the specific properties of LECs was hampered so far by lack of tools to isolate LECs. Recently, the 38-kD mucoprotein podoplanin was found to be expressed by microvascular LECs but not BECs in vivo. Here we isolated for the

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Smedsrød, B., L. Kjellén, and H. Pertoft. "Endocytosis and degradation of chondroitin sulphate by liver endothelial cells." Biochemical Journal 229, no. 1 (1985): 63–71. http://dx.doi.org/10.1042/bj2290063.

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Intravenously administered chondroitin sulphate, chemically labelled by [3H]acetylation of partially deacetylated polysaccharide, was taken up and degraded by the non-parenchymal cells of the liver. Studies using primary monolayer cultures of pure Kupffer cells, liver endothelial cells and parenchymal cells revealed that [3H]chondroitin sulphate was taken up and degraded by the liver endothelial cells only. Binding studies at 4 degrees C with [3H]chondroitin sulphate and 125I-chondroitin sulphate proteoglycan indicated that the glycosaminoglycan and the proteoglycan are recognized by the same

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Aboushoush, Tarek, Amira Kamel, Ahmed Montasser, Ahmed Ibrahim, and Heba Khalil. "Prognostic value of hyaluronidase-1 and CD44 immunohistological expression in gastric cancer." Egyptian Journal of Pathology 43, no. 1 (2023): 35–43. http://dx.doi.org/10.4103/egjp.egjp_9_23.

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Abstract Introduction Although many studies have investigated molecular markers for gastric cancer, the mechanisms of carcinogenesis remain obscure. CD44 serves as the principal transmembrane hyaluronate receptor. HAS1 has been identified as a key contributor to oncogenesis and disease progression in both hematological and solid cancers HAS1 has been shown to be prognostic factor in a variety of other cancers. Aim Our aim was to evaluate the expression of the CD44 and HAS1 as prognostic indicators for gastric cancer. Methodology Seventy five cases of gastritis and gastric cancer, obtained from

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Schroedl, Falk, Axel Brehmer, Winfried L. Neuhuber, Friedrich E. Kruse, C. Albrecht May, and Claus Cursiefen. "The Normal Human Choroid Is Endowed with a Significant Number of Lymphatic Vessel Endothelial Hyaluronate Receptor 1 (LYVE-1)–Positive Macrophages." Investigative Opthalmology & Visual Science 49, no. 12 (2008): 5222. http://dx.doi.org/10.1167/iovs.08-1721.

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Jian-lin, Zhou, Liu Shi-qing, Qiu Bo, Hu Qiong-jie, Ming Jiang-hua, and Peng Hao. "The Protective Effect of Sodium Hyaluronate on the Cartilage of Rabbit Osteoarthritis by Inhibiting Peroxisome Proliferator-Activated Receptor-Gamma Messenger RNA Expression." Yonsei Medical Journal 50, no. 6 (2009): 832. http://dx.doi.org/10.3349/ymj.2009.50.6.832.

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Culty, M., H. A. Nguyen, and C. B. Underhill. "The hyaluronan receptor (CD44) participates in the uptake and degradation of hyaluronan." Journal of Cell Biology 116, no. 4 (1992): 1055–62. http://dx.doi.org/10.1083/jcb.116.4.1055.

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The hyaluronan receptor belongs to the polymorphic family of CD44 glycoproteins, which have been implicated in a variety of cellular functions including adhesion to hyaluronan and collagen, the binding of lymphocytes to high endothelial cells during extravasation, and conferring metastatic potential to carcinoma cells. Here, we demonstrate that the receptor also participates in the uptake and degradation of hyaluronan by both transformed fibroblasts (SV-3T3 cells) and alveolar macrophages. These cells were incubated with isotopically labeled hyaluronan for various periods of time, and the exte

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Underhill, C. B., S. J. Green, P. M. Comoglio, and G. Tarone. "The hyaluronate receptor is identical to a glycoprotein of Mr 85,000 (gp85) as shown by a monoclonal antibody that interferes with binding activity." Journal of Biological Chemistry 262, no. 27 (1987): 13142–46. http://dx.doi.org/10.1016/s0021-9258(18)45179-4.

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Haynes, Barton F., Laura P. Hale, Karen L. Patton, Margaret E. Martin, and Rex M. McCallum. "Measurement of an adhesion molecule as an indicator of inflammatory disease activity: Up-regulation of the receptor for hyaluronate (CD44) in rheumatoid arthritis." Arthritis & Rheumatism 34, no. 11 (2010): 1434–43. http://dx.doi.org/10.1002/art.1780341115.

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Jamroziak, Krzysztof, Zofia Szemraj, Janusz Szemraj, et al. "Polymorphisms in CD31/PECAM-1 and CD38 Genes Are Associated with Susceptibility to Multiple Myeloma." Blood 112, no. 11 (2008): 5113. http://dx.doi.org/10.1182/blood.v112.11.5113.5113.

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Abstract Interactions with bone marrow microenvironment play a major role in the control of multiple myeloma (MM) growth and survival. MM clonal plasma cells co-express high levels of a signaling receptor CD38 and its ligand, the platelet endothelial adhesion molecule-1, CD31//PECAM-1. Homotypic and heterotypic interactions through these adhesion molecules (CD31/CD31, CD38/CD31 and CD38/hyaluronate interactions) may be involved in the pathogenesis of MM. The objective of this study was to investigate whether inherited variants in CD31/PECAM-1 and CD38 genes influence on susceptibility to MM. A

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Chung, Hyung-Min, Yun-Hee Rhee, Kwang-Yul Cha, and Jin-Young Baek. "Establishment and Characterization of Human Fetal Liver Derived Stem Cell Line." Blood 104, no. 11 (2004): 4265. http://dx.doi.org/10.1182/blood.v104.11.4265.4265.

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Abstract Mesenchymal stem cells (MSC) have been derived from different sources, including bone marrow and liver. To further support the hypothesis that MSC may also exist in most postnatal tissues, we isolated a clonogenic, multipotent, rapidly proliferating population of cells from a fetal liver and defined them as mesenchymal-like stem cells (FL-MLSC) derived from human fetal liver. In this study, FACS analysis showed that FL-MLSC are positive for CD105 (endoglin/SH-2), CD73 (5′ terminal nucleotidase/SH-3), CD166 (ALCAM-1), CD44 (the hyaluronate receptor), HLA class-I(HLA-ABC), CDw90 (thy-1)

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Galandrini, R., R. De Maria, M. Piccoli, L. Frati, and A. Santoni. "CD44 triggering enhances human NK cell cytotoxic functions." Journal of Immunology 153, no. 10 (1994): 4399–407. http://dx.doi.org/10.4049/jimmunol.153.10.4399.

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Abstract CD44, a major hyaluronate receptor, is involved in a variety of lymphocyte functions including lympho-hemopoiesis, adhesion to high endothelial venules or the extracellular matrix, and T cell activation. Here we investigated the ability of CD44 to affect the cytotoxic functions of human NK cells. Ligation of CD44 by selected mAb (J173 and F10442) resulted in a rapid, dose-response-dependent enhancement of NK cytotoxic activity against a panel of tumor target cells that varied in their sensitivity to NK killing. Neither enhanced killing against NK-resistant target cells nor CD44 mAb-me

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Garcia-del Portillo, F., M. G. Pucciarelli, W. A. Jefferies, and B. B. Finlay. "Salmonella typhimurium induces selective aggregation and internalization of host cell surface proteins during invasion of epithelial cells." Journal of Cell Science 107, no. 7 (1994): 2005–20. http://dx.doi.org/10.1242/jcs.107.7.2005.

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Salmonella interact with eucaryotic membranes to trigger internalization into non-phagocytic cells. In this study we examined the distribution of host plasma membrane proteins during S. typhimurium invasion of epithelial cells. Entry of S. typhimurium into HeLa epithelial cells produced extensive aggregation of cell surface class I MHC heavy chain, beta 2-microglobulin, fibronectin-receptor (alpha 5 beta 1 integrin), and hyaluronate receptor (CD-44). Other cell surface proteins such as transferrin-receptor or Thy-1 were aggregated by S. typhimurium to a much lesser extent. Capping of these pla

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