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Dissertations / Theses on the topic 'Hyaluronidase'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Lace, D. "Studies on modified hyaluronidase." Thesis, Bucks New University, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.384600.

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2

Savitsky, M. J. "Studies on mammalian hyaluronidase enzymes." Thesis, Bucks New University, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.382493.

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3

Lo, Bello M. "Studies on human placental hyaluronidase." Thesis, Cranfield University, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.385849.

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4

Joy, M. B. "Studies on the hyaluronidase of animal origin." Thesis, Bucks New University, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.376418.

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5

Ibberson, Carolyn Brook. "Hyaluronidase in Staphylococcus aureus physiology and pathogenesis." Diss., University of Iowa, 2015. https://ir.uiowa.edu/etd/5778.

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Staphylococcus aureus encodes for a secreted hyaluronidase, hysA. Hyaluronidases are bacterial enzymes that cleave hyaluronic acid (HA) at the β-1,4 glycosidic bond, yielding unsaturated disaccharides. Initially, little was known about the regulation of this enzyme as well as its roles in S. aureus physiology and pathogenesis. The goal of this dissertation was to determine the regulation of hysA, and to determine the biological and physiological roles of this enzyme. Studies presented in Chapter II focus on determining the regulation of hysA and role of hysA in S. aureus pathogenesis. By scree

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6

Muckenschnabel, Ingo. "Analytische Untersuchungen zum Einsatz von Hyaluronidase als Adjuvans in der Krebschemotherapie : quantitative Bestimmung und Pharmakokinetik von Hyaluronidase, Melphalan und Vinblastin /." [S.l.] : [s.n.], 1997. http://www.gbv.de/dms/bs/toc/245499245.pdf.

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7

Asteriou, Trias. "Cinétique de la réaction d'hydrolyse du hyaluronane catalysée par la hyaluronidase testiculaire bovine : Transposition à une hyaluronidase extraite de tumeurs cancéreuses humaines." Rouen, 2002. http://www.theses.fr/2002ROUES005.

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Le hyaluronane (HA) est un polysaccharide anionique linéaire constitué de motifs disaccharidiques (N-acétyl-D-glucosamine-b(1,3)-acide-D-glucuronique) liés en b(1,4). In vivo, son catabolisme est assuré par une famille d'enzymes, les hyaluronidases (HAase). Les HAase de type testiculaire hydrolysent les liens b(1,4). La réaction d'hydrolyse du HA catalysée par la HAase testiculaire et les paramètres qui la régulent n'ont été que peu étudiés. Par ailleurs, cette réaction semble impliquée dans le développement tumoral. Le présent manuscrit constitue une étude approfondie du mode de fonctionnemen

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8

Farrera, Sal Martí. "Enhanced hyaluronidase and tumor neoepitope expression by oncolytic adenoviruses." Doctoral thesis, Universitat de Barcelona, 2020. http://hdl.handle.net/10803/671748.

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The oncolytic viruses (OVs) preferentially infect tumor and selectively replicate in cancer cells without harming normal tissues. OVs have been tested in clinical trials as monotherapy or combined with chemotherapy, radiotherapy, and immunotherapy. Nonetheless, the intratumoral spreading and the immune response hamper the treatment efficacy. In this thesis, these two challenges have been addressed in three separate chapters. First, VCN-01, a hyaluronidase-expressing oncolytic adenovirus, was tested in a clinical trial in pancreatic cancer patients. We assessed the immune response triggered b

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9

Gatphayak, Kesinee. "Molecular characterization of the porcine hyaluronidase gene cluster on SSC13q21." Doctoral thesis, [S.l.] : [s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=970693656.

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10

Chowdhury, Biswajit. "Determining the role of murine hyaluronidase 2 in hyaluronan catabolism." The American Society for Biochemistry and Molecular Biology, 2013. http://hdl.handle.net/1993/31154.

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Hyaluronidase 2 (HYAL2) is a GPI-linked protein that is proposed to initiate the degradation of hyaluronan (HA), a major extracellular matrix component of many vertebrate tissues. Hyal2 knockout (KO) mice displayed craniofacial abnormalities and severe preweaning lethality. 54% of the surviving KOs developed a grossly dilated left or right atrium, requiring euthanasia, by 3 months of age. We hypothesize that the absence of HYAL2 leads to the accumulation of HA in organs/tissues where HA is normally abundant resulting in developmental defects and organs dysfunction. Molecular and histologic

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11

Brinkman, Jeremiah. "Gene Characterization of Hyaluronidase During Embryonic Development of Murine Hearts." The University of Arizona, 2009. http://hdl.handle.net/10150/623910.

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Class of 2009 Abstract<br>OBJECTIVES: The objective of this study was to characterize the Hyaluronidase (HYA) gene family throughout gestational development of murine hearts to provide greater insight regarding its role in cardiac morphogenesis. METHODS: Microdissection of murine embryos was accomplished to extract embryonic heart tissue. RNA was extracted using the standard Trizol protocol. cDNA templates were created using a standard protocol. Polymerase chain reaction (PCR) was used to verify presence of HYA, isolate a sample for insertion into a cloning plasmid to make a recombinant clone

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12

Doherty, Neil Christopher. "A molecular analysis of hyaluronate lyase production in Streptococcus pneumoniae." Thesis, University of Warwick, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.364616.

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13

Saindon, Andrée-Anne. "Caractérisation des isoformes de la protéine SPAM1 (Sperm Adhesion Molecule 1) et identification de ses partenaires d'interactions dans les spermatozoïdes." Master's thesis, Université Laval, 2017. http://hdl.handle.net/20.500.11794/27978.

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Sperm Adhesion Molecule 1 (SPAM1) est une protéine spermatique possédant une activité hyaluronidase dans son domaine N-terminal, contribuant à la dispersion des cellules du cumulus entourant l’ovocyte. Elle possède aussi une capacité de liaison à la zone pellucide (ZP) dans son domaine C-terminal. Nos études précédentes chez le taureau ont démontré la présence de deux isoformes potentielles de SPAM1 de ~70 et 80 kDa. Ces mêmes études ont permis d’émettre l’hypothèse que ces deux isoformes de SPAM1 ont des domaines C-terminaux différents, des origines différentes (testicule ou épididyme) et son

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14

Lemnitzer, Katharina, Jürgen Schiller, Jana Becher, Stephanie Möller, and Matthias Schnabelrauch. "Improvement of the Digestibility of Sulfated Hyaluronans by Bovine Testicular Hyaluronidase." Universitätsbibliothek Leipzig, 2014. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-147876.

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Glycosaminoglycans (GAGs) such as hyaluronan (HA) and chondroitin sulfate (CS) are important, natural polysaccharides which occur in biological (connective) tissues and have various biotechnological and medical applications. Additionally, there is increasing evidence that chemically (over)sulfated GAGs possess promising properties and are useful as implant coatings. Unfortunately, a detailed characterization of these GAGs is challenging: although mass spectrometry (MS) is one of the most powerful tools to elucidate the structures of (poly)saccharides, MS is not applicable to high mass polysacc

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15

Simmons, Kristin. "EFFECT OF HYALURONIDASE TREATMENT ON THE STRUCTURAL INTEGRITY OF THE ENDOTHELIAL GLYCOCALYX LAYER." VCU Scholars Compass, 2010. http://scholarscompass.vcu.edu/etd/2121.

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The endothelial glycocalyx plays an important role as part of the permeability barrier between the blood and the interstitium. In this study, we used different sized fluorescently labeled dextran molecules to determine the size of the macromolecular exclusion zone in capillaries. The width of the exclusion zone was calculated as one half the difference between the anatomic luminal diameter, as determined by transillumination, and the width of a fluorescent dextran column. During the first hour after systemic injection of labeled dextrans, neither 70 kDa dextran (Dextran 70) nor 500 kDa dext

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16

Seaton, Gavin. "Studies on RAT 2B1 antigen, a sperm surface protein with hyaluronidase activity." Thesis, University of Bristol, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.299309.

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17

Amar, Feriel. "Biodégradabilité de hyaluronanes hydrophobisés catalysée par la hyaluronidase : inhibition par interactions hydrophobes." Rouen, 2010. http://www.theses.fr/2010ROUES005.

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Grâce à son ensemble unique de propriétés physico-chimiques, le hyaluronane (HA) est utilisé dans l'élaboration de biomatériaux. Malgré son utilisation dans de nombreuses applications médicales, ses domaines d'application peuvent être plus vastes en modifiant chimiquement ses groupements fonctionnels afin de modifier et contrôler ses propriétés physico-chimiques. L'objectif de cette étude a été d'étudier l'activité de la hyaluronidase (HAase) sur le HA hydrophobiquement modifié à différents taux d'estérification et avec différentes longueurs de chaînes alkyle. Les fragments de HA sont obtenus

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18

Stecco, Antonio. "Ialuronidasi per la rigidità muscolare nella spasticità Hyaluronidase for muscle stiffness in spasticity." Doctoral thesis, Università degli studi di Padova, 2016. http://hdl.handle.net/11577/3424238.

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Background: Spasticity is a common neurological impairment after injury to the central nervous system, but the neural and biomechanical contributions to it are still poorly understood. Histopathological studies have demonstrated a generalized increase in extracellular connective tissue in spastic muscles, which can decrease its compliance, and reduce the threshold for stimulation of the spindle receptors. Here we propose and provide preliminary evidence for a novel hypothesis for exacerbation of spasticity in an immobilized limb - the hyaluronan hypothesis. We hypothesize that the extracellula

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19

Krishnapillai, Ashok M. "Studies on the utilisation of scampi (Nephrops norvegicus) waste with special reference to hyaluronidase." Thesis, University of Lincoln, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.240298.

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20

Dittberner, Mark. "Accelerated induction of etorphine immobilization in blue wildebeest (Connochaetes taurinus) by the addition of hyaluronidase." Diss., University of Pretoria, 2011. http://hdl.handle.net/2263/26364.

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Wild animal capture has progressed over the years from trapping or physical capture, which was dangerous to both animal and man, to chemical immobilization. Opioids and butyrophenones are the most common classes of drugs used for ungulate immobilization; however newer drugs and drug combinations are commonly used in an attempt to reduce time to immobilization in wildlife. The enzyme hyaluronidase is often added to drug combinations in the belief that it reduces time to immobilization by improving drug absorption. The primary objective of this study was to ascertain if the addition of hyaluroni

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21

Albeiroti, Sami. "The Role of Platelets in Hyaluronan Degradation." Cleveland State University / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=csu1417974134.

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22

Duan, Haohao. "Polymères à activités biologiques : nanoparticules et multivalence." Thesis, Bordeaux, 2016. http://www.theses.fr/2016BORD0114.

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Les nanoparticules à base d’acide hyaluronique (AH) sont utilisées pour de nombreuses applications pharmaceutiques. Elles peuvent cibler les tumeurs par interaction avec le CD44,qui est un récepteur biologique surexprimé à la surface de certaines cellules cancéreuses. Dans ce projet nous explorons l’application potentielle de ces nanoparticules dans les domaines cosmétiques, car l’AH est aussi un ingrédient important pour l’hydratation et le renouvellement de la peau. Les copolymères à bloc à base de polypeptides et de polysaccharides ont été synthétisés par une combinaison de polymérisation p

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23

Porsch, Helena. "Importance of Hyaluronan-CD44 Signaling in Tumor Progression : Crosstalk with TGFβ and PDGF-BB Signaling". Doctoral thesis, Uppsala universitet, Science for Life Laboratory, SciLifeLab, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-198165.

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In order for solid tumors to metastasize, tumor cells must acquire the ability to invade the surrounding tissue and intravasate into blood- or lymph vessels, survive in the circulation and then extravasate at a distant site to form a new tumor. Overexpression of the glycosaminoglycan hyaluronan, and its adhesion receptor CD44, correlate with breast cancer progression. This thesis focuses on the role of hyaluronan in tumor invasion and metastasis. In paper I, we demonstrated that upregulation of the hyaluronan synthesizing enzyme hyaluronan synthase 2 (HAS2) was crucial for transforming growth

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24

Morin, Guillaume. "Caractérisation de la protéine spermatique bovine p80 et étude de son rôle au cours de l'interaction entre les gamètes." Thesis, Université Laval, 2009. http://www.theses.ulaval.ca/2009/26003/26003.pdf.

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25

Textor, Christian [Verfasser], and Armin [Akademischer Betreuer] Buschauer. "Small molecules as inhibitors of streptococcal hyaluronidase: a computer-assisted and multicomponent synthesis approach / Christian Textor. Betreuer: Armin Buschauer." Regensburg : Universitätsbibliothek Regensburg, 2013. http://d-nb.info/1041484844/34.

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26

Hamberger, Janina [Verfasser], and Armin [Akademischer Betreuer] Buschauer. "Characterization of mammalian hyaluronidase-2 activity and identification of inhibitors of Streptococcal hyaluronan lyase / Janina Hamberger. Betreuer: Armin Buschauer." Regensburg : Universitätsbibliothek Regensburg, 2012. http://d-nb.info/1035300745/34.

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27

Lenormand, Hélène. "L’activité enzymatique de la hyaluronidase sous la dépendance de la complexation non-spécifique entre les hyaluronane et les protéines." Rouen, 2007. http://www.theses.fr/2007ROUES035.

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L’hydrolyse du hyaluronane (HA), polysaccharide de la matrice extracellulaire (MEC), est catalysée par la hyaluronidase (HAase). Les groupements carboxyl du HA lui confèrent un pouvoir complexant vis à vis des protéines influençant sa cinétique d’hydrolyse du HA. La complexation électrostatique non-spécifique entre le HA et des protéines est régie par des paramètres physicochimiques qui influencent l’état d’ionisation des biomacromolécules. Les complexes non-spécifiques que forment ensemble le HA et la HAase sont à l’origine d’une allure atypique des substrat- et enzyme-dépendances de l’hydrol

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28

Muggenthaler, Martina M. A., Biswajit Chowdhury, S. Naimul Hasan, et al. "Mutations in HYAL2, Encoding Hyaluronidase 2, Cause a Syndrome of Orofacial Clefting and Cor Triatriatum Sinister in Humans and Mice." PUBLIC LIBRARY SCIENCE, 2017. http://hdl.handle.net/10150/623116.

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Orofacial clefting is amongst the most common of birth defects, with both genetic and environmental components. Although numerous studies have been undertaken to investigate the complexities of the genetic etiology of this heterogeneous condition, this factor remains incompletely understood. Here, we describe mutations in the HYAL2 gene as a cause of syndromic orofacial clefting. HYAL2, encoding hyaluronidase 2, degrades extracellular hyaluronan, a critical component of the developing heart and palatal shelf matrix. Transfection assays demonstrated that the gene mutations destabilize the molec

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29

Colacioppo, Priscila Maria. "Uso da hialuronidase na prevenção do trauma perineal no parto normal: ensaio clínico aleatório placebo-controlado duplo-cego." Universidade de São Paulo, 2009. http://www.teses.usp.br/teses/disponiveis/7/7141/tde-11012010-151443/.

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A hialuronidase (HAase) é um complexo enzimático que age sobre o tecido conjuntivo frouxo. Existem vários estudos sobre a aplicação da HAase na região perineal, com a finalidade de reduzir a ocorrência de episiotomia e lacerações espontâneas. Apesar dos resultados positivos, as limitações metodológicas destes estudos justificam a controvérsia sobre os benefícios de sua utilização no parto normal. O objetivo do presente estudo foi comparar a frequência de trauma perineal e o grau de laceração perineal espontânea no parto normal, com e sem uso da HAase injetável no períneo. Trata-se de um ensaio

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30

Amorim, Fernanda Gobbi. "Clonagem e expressão heteróloga da hialuronidase e/ou novas toxinas obtidas a partir do transcriptoma da glândula da peçonha de Tityus serrulatus." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/60/60134/tde-02052016-153125/.

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As hialuronidases de peçonhas animais são capazes de clivar o hialuronan presente na matriz extracelular, facilitando a difusão das toxinas no tecido da vítima. Essas enzimas têm sido negligenciadas, devido à instabilidade enzimática e à baixa concentração na peçonha. Assim, a expressão heteróloga das hialuronidases permite a sua obtenção em quantidades que viabilizam seu estudo estrutural e funcional. Associado a isso, o transcriptoma propicia a identificação de novas toxinas e componentes de baixa proporção na peçonha. Portanto, o presente trabalho realizou o transcriptoma da glândula de peç

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31

Wilhelm, Kelsey. "A Systematic Review of Hyaluronidase‐Assisted Subcutaneous Fluid Administration in Pediatrics and Geriatrics and Its Potential Application in Low Resource Settings." Thesis, The University of Arizona, 2017. http://hdl.handle.net/10150/623621.

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A Thesis submitted to The University of Arizona College of Medicine - Phoenix in partial fulfillment of the requirements for the Degree of Doctor of Medicine.<br>The role of enzyme‐assisted subcutaneous fluid administration (EASFA) in treating mild to moderate dehydration in pediatrics, geriatrics, and palliative care has been studied in developed countries. However, it has historically been underutilized due to widely available health care and alternative treatments, namely peripheral intravenous (IV) fluid administration. Fluid infusions in the subcutaneous tissue have a low risk of infectio

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32

Maria, Adriana Del Monaco de. "Subclonagem, expressão e purificação da enzima hialuronidase-1, variante 8, humana." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/9/9136/tde-25032014-105024/.

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O Ácido Hialurônico, HA, é um dos principais componentes da matriz extracelular dos vertebrados. É um glicosaminoglicano hidrolisado pelas enzimas da família da Hialuronidase, envolvidas na regulação de importantes processos biológicos, como a permeabilidade vascular e a angiogênese. Conforme o interesse pelo desenvolvimento de uma rota de síntese para esta enzima, objetivamos a obtenção de um plasmídeo, contendo a sequência que codifica a variante 8 do gene Hyal-1. Para isto, planejou-se a inserção de dois sítios de restrição para a sub-clonagem, sítio dirigida, BamH-1 na região 5\' e Not-1 n

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33

Rodríguez, García Alba. "Enhancing the Antitumor Activity of Oncolytic Adenoviruses by Combining Tumor Targeting with Hyaluronidase Expression or by Increasing the Immunogenicity of Exogenous Epitopes." Doctoral thesis, Universitat de Barcelona, 2015. http://hdl.handle.net/10803/290068.

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Oncolytic adenoviruses represent an appealing therapeutic approach to treat cancer regarding its capability to infect and kill selectively tumor cells without damaging normal tissues. Tumor targeting upon intravenous administration and subsequent intratumoral virus dissemination are key features to improve oncolytic adenovirus therapy. To address these hurdles, in this work we have combined two different genetic modifications previously described by our group in an oncolytic adenovirus backbone with selective replication conditional to pRB pathway deregulation. First, the replacement of the he

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34

Hyde, Cheryl Elaine. "'The regulation of the Xenopus nodal related-1 gene, Xnr-1' and 'the isolation and characterisation of a novel Xenopus hyaluronidase, XEH1'." Thesis, University of Warwick, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.364607.

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35

Tranchepain, Frédéric. "Interactions hyaluronane-protéines : hydrolyse du hyaluronane caractérisée par la hyaluronidase et complexation non spécifique hyaluronane-protéines. Influence de la longueur de la chaîne de hyaluronane." Rouen, 2004. http://www.theses.fr/2004ROUES060.

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36

Meyer, Carolin [Verfasser], and Armin [Akademischer Betreuer] Buschauer. "Synthesis and structure-activity relationships of inhibitors of bacterial hyaluronidase: An approach to obtain compounds with drug-like properties / Carolin Meyer. Betreuer: Armin Buschauer." Regensburg : Universitätsbibliothek Regensburg, 2014. http://d-nb.info/1050592018/34.

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37

Remy, Matthias. "Randomisierte, Placebo-kontrollierte klinische Phase III-Doppelblindstudie zur Wirksamkeit und Sicherheit von Hyaluronidase, Hylase® „Dessau“ 75 I.E. als Zusatz zu Lokalanästhetika bei der Kataraktoperation." Diss., lmu, 2007. http://nbn-resolving.de/urn:nbn:de:bvb:19-75680.

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Booth, Andrew. "Controlled release of active compounds from a magnetic nanoparticle-vesicle aggregate nanomaterial." Thesis, University of Manchester, 2015. https://www.research.manchester.ac.uk/portal/en/theses/controlled-release-of-active-compounds-from-a-magnetic-nanoparticlevesicle-aggregate-nanomaterial(5c87df99-8ab3-4965-bdc2-081333be1ef9).html.

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Non-invasive and controlled release of bioactive compounds is an important goal in the development of drug delivery systems and novel biomaterials for tissue engineering. This project aims to exert spatio-temporal control over the release of bioactive compounds from phospholipid vesicle carriers by crosslinking them with superparamagnetic iron oxide nanoparticles to form a magnetic release nanostructure. The magnetic properties of the nanoparticles allow release to be triggered by an alternating magnetic field (AMF), which induces localised heating and “melts” the vesicle membranes. The aggreg

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Pinter, Florian. "Randomisierte, Placebo-kontrollierte klinische Phase III Doppelblindstudie zur Wirksamkeit und Sicherheit von 75 I.E. Hyaluronidase als Zusatz zu Lokalanästhetika in entweder kombinierten Cataract-Glaskörperoperationen oder Glaskörperoperationen." Diss., lmu, 2010. http://nbn-resolving.de/urn:nbn:de:bvb:19-117486.

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40

Siponen, M. (Maria). "Oral lichen planus – etiopathogenesis and management." Doctoral thesis, Oulun yliopisto, 2017. http://urn.fi/urn:isbn:9789526214702.

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Abstract Oral lichen planus (OLP) is a chronic immune-mediated mucosal disease with unknown etiology. According to the current view, the pathogenesis of OLP involves activation of T-cell mediated immunity against the epithelial keratinocytes. A proportion of OLP patients are affected by painful symptoms, and the risk of oral cancer is increased in OLP. There is no curative treatment for OLP. Topical corticosteroids are used most commonly in the management of OLP. However, the evidence base for the effectiveness of any therapy is weak. The objective of this thesis was to study novel aspects of

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41

Rügheimer, Louise. "Kidney Hyaluronan : Regulatory Aspects During Different States of Body Hydration, Nephrogenesis & Diabetes." Doctoral thesis, Uppsala University, Department of Medical Cell Biology, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8724.

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<p>The kidney regulates the excretion of water and electrolytes, which maintains homeostasis and enables control of arterial blood pressure. Hyaluronan, a large negatively charged interstitial glucosaminoglycan, is heterogeneously distributed within the kidney, primarily found in the medulla.</p><p>Medullary hyaluronan content changes depending on the state of body hydration and plays a part in fluid regulation through its water binding and viscoelastic properties. </p><p>The aim of this thesis was to provide new insight into the regulation of intrarenal hyaluronan during different states of b

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42

Bordon, Karla de Castro Figueiredo. "Caracterização funcional e estrutural da hialuronidase isolada da peçonha de serpente Crotalus durissus terrificus." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/60/60134/tde-04092012-161625/.

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Hialuronidases são responsáveis pela hidrólise de hialuronan, o principal componente da matriz intersticial. Estas enzimas são ubíquas nas peçonhas de serpentes, contudo suas concentrações e características podem variar entre as espécies. Embora estudos indiquem a presença de atividade hialuronidásica na peçonha de Crotalus durissus terrificus e a hialuronidase apresente importante papel no envenenamento local e sistêmico, a enzima ainda não havia sido estudada. Os objetivos deste trabalho focaram o isolamento e a caracterização funcional e estrutural da hialuronidase (CdtHya1) presente na peç

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43

Orlando, Zoya [Verfasser], and Joachim [Akademischer Betreuer] Jose. "Humane Hyaluronidasen als Wirkstofftargets / Zoya Orlando ; Betreuer: Joachim Jose." Münster : Universitäts- und Landesbibliothek Münster, 2015. http://d-nb.info/113828159X/34.

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44

Smith, Nicola L. "Analysis of a family 6 carbohydrate-binding module and three family 69 hyaluronidases." Thesis, Northumbria University, 2005. http://nrl.northumbria.ac.uk/2268/.

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To investigate the interactions between a family 6 carbohydrate-binding module (CBM) from Clostridium thermocellum Xynl 1A (CtCBM6) and its target ligands and to identify the location of the ligand binding site(s) through a mutagenesis strategy, the protein was expressed in Escherichia coli and purified to homogeneity. CtCBM6 was shown previously to interact with xylan (Fernandes et al., 1999) and, informed by the crystal structure, it was found that CtCBM6 was unusual, as it contained two potential ligand-binding clefts (Clefts A and B). Qualitative ligand specificity studies through affinity

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Kurdykowski, Sandrine. "Etude de la dégradation des glycosaminoglycannes au cours du vieillissement cutané intrinsèque et photo-induit." Reims, 2010. http://www.theses.fr/2010REIMM205.

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Pelletier, Ludivine. "Un nouveau rôle pour CD44 dans la transformation cellulaire." Lyon 1, 2006. http://www.theses.fr/2006LYO10103.

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La protéine d’adhérence CD44 est exprimée de façon aberrante dans plusieurs types de cancers mais les mécanismes moléculaires par lesquels elle participe à la tumorigénèse restent mal définis. Le modèle couramment retenu lui attribue un rôle dans la capacité métastatique, un évènement tardif de la tumorigénèse. L’utilisation d’un système original qui mime une activation inductible et réversible de l’oncogène RET dans des fibroblastes de rat, nous a permis de montrer que CD44 participe également aux étapes plus précoces du développement tumoral. L’augmentation d’expression de CD44 au cours de l

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Larnier, Catherine. "Étude de la régulation de la biosynthèse de l'acide hyaluronique par les fibroblastes de la peau humaine en culture." Paris 12, 1990. http://www.theses.fr/1990PA120008.

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La depletion de l'acide hyaluronique (ha) a la surface cellulaire par hydrolyse enzymatique induit une stimulation de la synthese d'ha qui est dose et temps dependants et qui resulte en une activation de la hyaluronate synthetase. Elle fait intervenir partiellement une synthese proteique. La stimulation de la synthese d'ha est reversible et necessite pour etre prolongee la persistance de l'enzyme. La stimulation ne depend ni du type de liaison glycosidique clivee par la hyaluronidase ni de l'hydrolyse des chondroitines sulfates et/ou du dermatane sulfate. La synthese des glycosaminglycanes sul

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Schanté, Carole. "Chemical modifications of hyaluronic acid for the development of bioresorbable medical devices." Strasbourg, 2011. http://www.theses.fr/2011STRA6198.

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L’objectif de ce travail de thèse était de développer un nouveau dérivé d’acide hyaluronique (HA) ayant une action thérapeutique plus longue que les produits actuellement sur le marché. Une modification chimique efficace constistant en le greffage d’acides aminés sur les groupements carboxyliques de l’HA permis d’obtenir des dérivés ayant une meilleure résistance enzymatique in vitro comparée à l’HA de départ. Trois réactions d’amidation ont été évaluées pour l’obtention de taux de greffage élevés. La prochaine étape a porté sur la réticulation des dérivés HA-acides aminés qui a été accomplie

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Trochon, Véronique. "Apport du système de l'acide hyaluronique et des protéases de la famille des adamalysines à la régulation physiopatologique et pharmacologique de l'angiogénèse." Rouen, 1998. http://www.theses.fr/1998ROUE03NR.

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L'angiogénèse est un processus indispensable à la croissance et au développement d'une tumeur. Afin d'analyser les facteurs qui contribuent à l'angiogénèse et d'essayer par la suite de les contrôler, nous nous sommes intéressés : - aux facteurs de l'environnement, principalement au système de l'acide hyaluronique (AH) et plus accessoirement aux cytokines sécrétées par les monocytes activés qui peuvent infiltrer une tumeur - à une nouvelle classe de métalloprotéinases transmembranaires (ADAM/MDC(s) ou adamalysines) associées aux cellules endothéliales (CEs). L'AH est un glycosaminoglycanne de h

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Le, Masson Jérémy. "Modulation de l’aromatase et de la signalisation oestrogénique par altération du métabolisme de l’acide hyaluronique dans une lignée tumorale mammaire oestrogéno-dépendante (MCF-7) et une lignée tumorale de granulosa oestrogéno-résistante (KGN)." Caen, 2013. http://www.theses.fr/2013CAEN2009.

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Une des caractéristiques majeures des carcinomes les plus agressifs issus des tissus stéroïdo-dépendants réside dans la perte de la sensibilité aux stéroïdes associée à la forte expression des protéines responsables de la synthèse (Hyaluronate synthases ou HAS), de la dégradation (Hyaluronidases ou HYAL) et de la liaison membranaire (CD44) de l’acide hyaluronique (AH), glycosaminoglycanne non sulfaté de haut poids moléculaire. Pour évaluer un possible antagonisme fonctionnel entre signalisation oestrogénique et activité du « hyaluronome », l’expression génique de HYAL1 a été modifiée de manièr

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