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Journal articles on the topic 'Hybridisors'
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Behrends, Jeff. "Problems and solutions for a hybrid approach to grounding practical normativity." Canadian Journal of Philosophy 45, no. 2 (2015): 159–78. http://dx.doi.org/10.1080/00455091.2015.1047684.
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Source Hybridism about practical reasons is the position that facts that constitute reasons sometimes derive their normative force from external metaphysical grounds, and sometimes from internal. Although historically less popular than either Source Internalism or Source Externalism, hybridism has lately begun to garner more attention. Here, I further the hybridist’s cause by defending Source Hybridism from three objections. I argue that we are not warranted in rejecting hybridism for any of the following reasons: that hybridists cannot provide an account of normative weight, that hybridists are committed to implausible results concerning practical deliberation, or that Source Hybridism is objectionably unparsimonious.
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Tavares, Fátima Regina Gomes. "Hybridismes spirituels: autonomie et globalisation du mouvement New Age." Social Compass 57, no. 1 (2010): 100–109. http://dx.doi.org/10.1177/0037768609355543.
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Küster, Volker. "Von der lokalen Theologie zur neuen Katholizität." Evangelische Theologie 63, no. 5 (2003): 362–74. http://dx.doi.org/10.14315/evth-2003-0506.
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Zusammenfassung Robert J. Schreiters Erfahrungshorizont ist die katholischeWeltkirche, die in der Vielzahl der Ortskirchen vergegenwärtigt ist. Gebrochen wird diese ekklesiologische Orientierung durch seine Forderung nach einer Theologie der Kultur, die zwischen dem Lokalen und dem Globalen bzw. der Kontextualität und der Interkulturalität des christlichen Glaubens agiert. Dem liegt eine ausdifferenzierte Kulturkonzeption zugrunde, die die Kontexte als entterritorialisert, überdifferenziert und hybridisert beschreibt. Dieser Glokaliserung (Roland Robertson) setzt Schreiter die Vision einer neuen Katholizität entgegen, die mit Hilfe einer Hermeneutik der interkulturellen Kommunikation ihre integrative Kraft entfalten soll.
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Austin, JJ, and DT Parkin. "Female-Specific Restriction Fragments Revealed by Dna-Fingerprinting and Implications for Extra-Pair Fertilisations in the Short-Tailed Shearwater (Puffinus-Tenuirostris, Procellariiformes, Procellariidae)." Australian Journal of Zoology 43, no. 5 (1995): 443. http://dx.doi.org/10.1071/zo9950443.
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We report a female-specific restriction fragment in the DNA fingerprints of short-tailed shearwaters (Puffinus tenuirostris) that hybridises to a derivative of the human multilocus minisatellite probe 33.6. This genetic method of assigning sex has relevance to studies of population biology, reproductive success and mating systems in this species. The presence or absence of the female-specific restriction fragment has allowed us to reinterpret results from a previous DNA fingerprinting study of mating systems in the short-tailed shearwater.
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Cover, Michael Benjamin. "The Divine Comedy at Corinth: Paul, Menander and the Rhetoric of Resurrection." New Testament Studies 64, no. 4 (2018): 532–50. http://dx.doi.org/10.1017/s0028688518000140.
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This article asks how the New Comedy of Menander might have influenced Paul's theological rhetoric in 1 Cor 5–15. An intertextual reading of Paul's letter against the backdrop of Menander'sSamiareveals a number of shared topics, ethical concerns and dramatic characteristics. Paul's citation of Menander'sThaisin 1 Cor 15.33 is part of this larger strategy to frame the struggles in Corinth within the ambit of Greek household ‘situation comedy’. Like Menander, Paul hybridises tragic and comic motifs throughout his epistle, inflecting the comedy of the Christ narrative with tragic examples of human misapprehension in this plea for ecclesial reconciliation.
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Lienhard, Martin. "Of Mestizajes, heterogeneities, hybridisms and other chimeras: On the macroprocesses of cultural interaction in Latin America." Journal of Latin American Cultural Studies 6, no. 2 (1997): 183–200. http://dx.doi.org/10.1080/13569329709361911.
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Rosales Rodríguez, Amán. "Ensayismo y “revelación poética” en Octavio Paz." Acta Philologica, no. 61 (2023) (December 29, 2023): 105–14. http://dx.doi.org/10.7311/acta.61.2023.9.
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This article explores certain characteristics of Octavio Paz’s essay writing based on a commentary on El mono gramático. This work is an example not only of textual hybridism but also of essayism as a prevailing attitude in the intellectual production of the Mexican author. The main objective of the paper is to highlight the relationship between essayism as a producer of generic hybridisms with Paz’s reflections on “poetic revelation”, a subject developed by Paz in El arco y la lira-. In El mono gramático the author attempts an approach to such a revelation that considers both the finite nature of the human being and aspirations of transcendence.
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Bastos, Cristiana. "Medical Hybridisms and Social Boundaries: Aspects of Portuguese Colonialism in Africa and India in the Nineteenth Century." Journal of Southern African Studies 33, no. 4 (2007): 767–82. http://dx.doi.org/10.1080/03057070701646878.
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Pyykkönen, Miikka, Sakarias Sokka, and Ari Kurlin Niiniaho. "Yrittäjätaiteilijat vapauden, luovuuden ja toimeentulon rajapinnoilla." Työelämän tutkimus 19, no. 1 (2021): 57–81. http://dx.doi.org/10.37455/tt.102880.
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Keskitymme artikkelissamme nuorten (alle 35-vuotiaiden), taiteilijoina toimivien yrittäjien ja freelancereiden näkemyksiin omasta työstään, työolosuhteistaan ja tuloistaan. Aineistonamme on Kulttuuripolitiikan edistämissäätiön ja Taiteen edistämiskeskuksen keräämä Nuoret taiteentekijät ‑kyselyaineisto vuodelta 2018 (n = 565). Erotimme aineistosta artikkelimme otokseksi yrittäjien ja freelancereiden (n = 209) edellä mainittuja asioita koskevat vastaukset. Käytämme heistä yhteisnimitystä yrittäjätaiteilijat. Tutkimme eri tekijöiden vaikutuksia yrittäjätaiteilijoiden työtyytyväisyyteen suorien jakaumien sekä ristiintaulukointien ja niitä koskevien riippumattomuustestien ja korrelaatiokertoimien avulla. Lähestymme aihetta kulttuuri- ja taidealojen työtä koskevien aiempien tutkimusten tulosten ja teoretisointien valossa. Tulkintakehyksen keskeisiä käsitteitä ovat taiteilijoiden työn hybridisyys ja työnteon prekaarisuus, joita kuvaavia esimerkkejä nostamme esiin myös aineistoon sisältyvistä kirjallisista vastauksista. Keskeisimpinä tuloksina toteamme, että yrittäjätaiteilijat ovat työssään muita nuoria taiteilijoita monialaisempia ja monituloisempia, ja he pärjäävät muita paremmin prekaarin työelämän epävarmuustekijöiden kanssa.
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Lambert, James. "A multitude of “lishes”." English World-Wide 39, no. 1 (2018): 1–33. http://dx.doi.org/10.1075/eww.00001.lam.
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Abstract The present paper deals with portmanteau terms based on the word English, the bulk of which form a varied and extensive nomenclature used to describe hybrids of the English language with other languages. A citation database of over 3,500 entries was created containing 510 separate terms dating from the early 20th century to mid-2016. These figures indicate a widespread interest in the ways in which English hybridises with other languages and becomes localised in various parts of the globe. The results also show a trend of continuing increase in the coining of such terms to be expected in an increasingly globalised world. However, to date there has been no exhaustive examination of names for English-language hybrids. The present paper examines these portmanteau terms with regard to semantics, etymology, history, frequency, and pronunciation, and presents an alphabetical table of the complete set of terms in the Appendix.
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Mohamed, Basma, and Mohamed Amin. "A HYBRID OPTIMIZATION ALGORITHMS FOR SOLVING METRIC DIMENSION PROBLEM." International Journal on Applications of Graph Theory In wireless Ad Hoc Networks And sensor Networks 15, no. 1/2 (2023): 1–10. http://dx.doi.org/10.5121/jgraphoc.2023.15201.
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In this paper, we consider the NP-hard problem of finding the minimum resolving set of graphs. A vertex set B of a connected graph G resolves G if every vertex of G is uniquely identified by its vector of distances to the vertices in B. The cardinality of the minimal resolving set is the metric dimension of G. The metric dimension appears in various fields such as network discovery and verification, robot navigation, combinatorial optimization and pharmaceutical chemistry, etc. In this study, we introduce a hybrid approach (WCA_WOA) for computing the metric dimension of graphs that combines the water cycle algorithm and a whale optimisation algorithm. The WOA algorithm hybridises the WCA in order to obtain the optimal result and manage the optimization process. The results of the experiments show that the WCA_WOA hybrid algorithm outperforms the WCA, WOA, and particle swarm optimization methods
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Barrington, David S. "Hybridisation in Costa Rican Polystichum." Proceedings of the Royal Society of Edinburgh. Section B. Biological Sciences 86 (1985): 335–40. http://dx.doi.org/10.1017/s0269727000008307.
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SynopsisPolystichum muricatum hybridises with both P. polyphyllum and P. speciosissimum on the Cerro de la Muerte in Costa Rica. Both hybrids are intermediate between their two parents in most of the assessed characters. True indusia, which are fully developed in P. muricatum, vestigial in P. polyphyllum, and absent in P. speciosissimum, are intermediate in mean development in both hybrids. However, one sorus is likely to have either a fully-developed indusium or a vestigial indusium. False indusia are characteristic of P. speciosissimum, but are vestigial to absent in its hybrid with P. muricatum. False-indusium development appears to behave as a recessive trait in the interaction of P. speciosissimum with P. muricatum.Environmental disturbance has played a major role in the development of hybrids in Costa Rica. Mixed populations of the parent species are more common in disturbed terrain than in pristine areas, and hybrids are found only in disturbed terrain; this suggesting that disturbance promotes hybridisation.
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Qiu, Binbin, Yang Lu, Xianqiang Qu, and Xu Li. "Experimental Research on a Hybrid Algorithm for Localisation and Reconstruction of the Impact Force Applied to a Rectangular Steel Plate Structure." Sensors 22, no. 21 (2022): 8123. http://dx.doi.org/10.3390/s22218123.
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Impact force is the most common form of load which acts on engineering structures and presents a great hidden risk to the healthy operation of machinery. Therefore, the identification or monitoring of impact forces is a significant issue in structural health monitoring. The conventional optimisation scheme based on inversion techniques requires a significant amount of time to identify random impact forces (impact force localisation and time history reconstruction) and is not suitable for engineering applications. Recently, a pattern recognition method combined with the similarity metric, PRMCSM, has been proposed, which exhibits rapidity in practical engineering applications. This study proposes a novel scheme for identifying unknown random impact forces which hybridises two existing methods and combines the advantages of both. The experimental results indicate that the localisation accuracy of the proposed algorithm (100%) is higher than that of PRMCSM (92%), and the calculation time of the hybrid algorithm (179 s) for 25 validation cases is approximately one nineteenth of the traditional optimisation strategy (3446 s).
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Tiwari, Kretika, and Dileep Kumar Singh. "Social Media Based Deep Auto-Encoder Model for Clinical Recommendation." International Journal on Recent and Innovation Trends in Computing and Communication 10, no. 1s (2022): 44–51. http://dx.doi.org/10.17762/ijritcc.v10i1s.5794.
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One of the most actively studied topics in modern medicine is the use of deep learning and patient clinical data to make medication and ADR recommendations. However, the clinical community still has some work to do in order to build a model that hybridises the recommendation system. As a social media learning based deep auto-encoder model for clinical recommendation, this research proposes a hybrid model that combines deep self-decoder with Top n similar co-patient information to produce a joint optimisation function (SAeCR). Implicit clinical information can be extracted using the network representation learning technique. Three experiments were conducted on two real-world social network data sets to assess the efficacy of the SAeCR model. As demonstrated by the experiments, the suggested model outperforms the other classification method on a larger and sparser data set. In addition, social network data can help doctors determine the nature of a patient's relationship with a co-patient. The SAeCR model is more effective since it incorporates insights from network representation learning and social theory.
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Roy, Anjali Gera. "Black beats with a Punjabi twist." Popular Music 32, no. 2 (2013): 241–57. http://dx.doi.org/10.1017/s0261143013000111.
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AbstractThe bonding between black and brown immigrants in Britain has resulted in the emergence of a new musical genre called Bhangra, which hybridises Punjabi dhol rhythms with those of reggae, rap and hip hop. Bhangra's appropriation of Black sounds that are considered ‘Kool’ in the West has not only given Asian youth a new, distinctive voice in the form of ‘Asian dance music’ but has also led to the reinvention of Punjabi folk tradition in consonance with the lived realities of multicultural Britain. This essay examines various aspects of sonic hybridisation in ‘the diaspora space’ by British Asian music producers through tracing the history of Bhangra's ‘douglarisation’, beginning in the 1990s with Apache Indian's experiments with reggae. It covers all forms of mixings that came in between, including active collaborations, rappings, remixings, samplings and so on that made Punjabi and Jamaican patois dialogue in the global popular cultural space. The essay explores the possibilities of a ‘douglas poetics’ for Bhangra by juxtaposing the celebration of sonic douglarisation in postmodern narratives of migrancy and hybridity against the stigmatisation of biological douglarisation in miscegenation theories and ancient Indian pollution taboos.
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Matsubara, Kazumi, Denis O’Meally, Stephen D. Sarre, Arthur Georges, Kornsorn Srikulnath, and Tariq Ezaz. "ZW Sex Chromosomes in Australian Dragon Lizards (Agamidae) Originated from a Combination of Duplication and Translocation in the Nucleolar Organising Region." Genes 10, no. 11 (2019): 861. http://dx.doi.org/10.3390/genes10110861.
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Sex chromosomes in some reptiles share synteny with distantly related amniotes in regions orthologous to squamate chromosome 2. The latter finding suggests that chromosome 2 was formerly part of a larger ancestral (amniote) super-sex chromosome and raises questions about how sex chromosomes are formed and modified in reptiles. Australian dragon lizards (Agamidae) are emerging as an excellent model for studying these processes. In particular, they exhibit both genotypic (GSD) and temperature-dependent (TSD) sex determination, show evidence of transitions between the two modes and have evolved non-homologous ZW sex microchromosomes even within the same evolutionary lineage. They therefore represent an excellent group to probe further the idea of a shared ancestral super-sex chromosome and to investigate mechanisms for transition between different sex chromosome forms. Here, we compare sex chromosome homology among eight dragon lizard species from five genera to identify key cytological differences and the mechanisms that may be driving sex chromosome evolution in this group. We performed fluorescence in situ hybridisation to physically map bacterial artificial chromosome (BAC) clones from the bearded dragon, Pogona vitticeps’ ZW sex chromosomes and a nucleolar organising region (NOR) probe in males and females of eight Agamid species exhibiting either GSD or TSD. We show that the sex chromosome derived BAC clone hybridises near the telomere of chromosome 2q in all eight species examined. This clone also hybridises to the sex microchromosomes of three species (P vitticeps, P. barbata and Diporiphora nobbi) and a pair of microchromosomes in three others (Ctenophorus pictus, Amphibolurus norrisi and Amphibolurus muricatus). No other chromosomes are marked by the probe in two species from the closely related genus Physignathus. A probe bearing nucleolar organising region (NOR) sequences maps close to the telomere of chromosome 2q in all eight species, and to the ZW pair in P. vitticeps and P. barbata, the W microchromosome in D. nobbi, and several microchromosomes in P. cocincinus. Our findings provide evidence of sequence homology between chromosome 2 and the sex chromosomes of multiple agamids. These data support the hypothesis that there was an ancestral sex chromosome in amniotes that gave rise to squamate chromosome 2 and raises the prospect that some particular property of this chromosome has favoured its role as a sex chromosome in amniotes. It is likely that the amplification of repetitive sequences associated with this region has driven the high level of heterochromatinisation of the sex-specific chromosomes in three species of agamid. Our data suggest a possible mechanism for chromosome rearrangement, including inversion and duplication near the telomeric regions of the ancestral chromosome 2 and subsequent translocation to the ZW sex microchromosomes in three agamid species. It is plausible that these chromosome rearrangements involving sex chromosomes also drove speciation in this group.
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Monterrubio-Ibáñez, Lourdes. "Zapping Zone and Level Five. Between the visitor’s experience of the video installation and the filmmaker’s reflection of the essay film." Arte, Individuo y Sociedad Avance en línea (September 4, 2023): 1–16. http://dx.doi.org/10.5209/aris.87867.
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The displacement from the essay film to the video installation has in Chris Marker one of its first and most relevant figures. The comparative study of Zapping Zone. Proposal for an imaginary television (1990) and Level Five (1997) allows for the analysis of the construction and complexification, and the deconstruction and saturation processes that take place between the most complex expression of the Markerian essay film and its transformation into the video installation. Zapping Zone responds to the embodiment of both the magmatic stage of the postmodern audiovisual era and the starting point of the filmmaker's work (documentaries, essay films, video installations, etc.), which would be the opposite of the writer’s blank page: a saturated world of images that needs to be selected, analysed and worked on in order to build meaning. Level Five offers the filmmaker’s reflection on that same reality, applied to the Battle of Okinawa, through a complex audiovisual thinking process that hybridises different types of images—documentary and fictional; analogue and electronic—devices—epistolary video diary, video game and cyberspace—and their authorial subjectivities—Laura, Laura’s lover and Chris—in order to reflect on the relationship between these audiovisual forms and spaces and the thematic axis memory-pain-oblivion.
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Salemink, Oscar, Poulsen Rasmus Rask, and Ahl Sofie Isager. "Sacred but not holy: Awe, spectacle, and the heritage gaze in Danish religious heritage contexts." Anthropological Notebooks 26, no. 3 (2020): 70–99. https://doi.org/10.5281/zenodo.4604148.
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<strong>Abstract</strong> Based on an ideal-typical distinction between the “holy” and the “sacred”, this paper considers the effects of the heritagisation of religious spaces in the three Danish World Heritage sites of Jelling, Roskilde, and Christiansfeld. Religious sites are often intended as spectacles inspiring religious awe in the religious constituency, but when considered heritage, the site becomes a spectacle for a different public, for whom the sacrality of the place is not necessarily motivated by religious piety. Instead, the church as heritage site may be a sacralised focal point for ontological pride on behalf of another, secular constituency, like the region or nation, or for vicarious nostalgia of a tourist public. The religious congregation itself might become the object of a heritage gaze on the part of cultural experts and tourists who foreground the “authenticity” of the religious experience in the spatial environment of the place in line with UNESCO principles. In this paper, we argue that the overlaying of a heritage gaze over a religious gaze results in the potential hybridisation of religion as a category of heritage. This not only hybridises religious piety but inadvertently frames it <em>as</em> cultural heritage through the secular, immanent frame of heritage.
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Craig, J. M., S. Boyle, P. Perry, and W. A. Bickmore. "Scaffold attachments within the human genome." Journal of Cell Science 110, no. 21 (1997): 2673–82. http://dx.doi.org/10.1242/jcs.110.21.2673.
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It is generally agreed that, above the level of the 30 nm fibre, eukaryotic chromatin is constrained into loops, but there is disagreement about the nature of the substructure that serves to anchor loops and the DNA sequences that act as the attachment sites. This problem may stem from the very different methods that all purport to separate loop and attached DNAs. We have tested ideas about how the genome is arranged into loops by analysing the average loop size over different cytologically resolvable regions of human chromosomes using fluorescence in situ hybridisation with loop and attached DNA fractions. Variations in average loop size, along and between chromosomes, measurable at this level of resolution were small but significant and were dependent on the extraction method. This emphasises the fundamental differences between the nuclear substructure probed by different protocols. DNA attached to the nuclear ‘scaffold’ or ‘matrix’ hybridises preferentially to gene-poor regions of the genome (G-bands). Conversely, fractions attached to the nuclear ‘skeleton’ hybridise preferentially to gene-rich R-bands and sites of high levels of transcription. The inactive X chromosome has a deficit of associations with the nuclear skeleton but not with the matrix or scaffold. A large excess of attached sequences is found at some sites of constitutive heterochromatin, but not at centromeres.
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Chelpa Ferro (Sergio Mekler, Barrão, Luiz Zerbini), Livia Flores, Dinah De Oliveira, et al. "Máquinas de desejo e risco aparecem e se dissipam: entrevista com Chelpa Ferro." Arte e Ensaios 30, no. 48 (2025): 12–48. https://doi.org/10.60001/ae.n48.2.
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Nesta entrevista realizada via zoom em 18 de setembro de 2024, os membros do Chelpa Ferro, Sergio Mekler, Barrão e Luiz Zerbini, falam sobre os momentos e impulsos que originaram o coletivo no memorável CEP 20.000, em diálogo com suas trajetórias e com o desejo de fazer música. Os artistas refletem a partir de suas práticas experimentais discorrendo sobre as operatórias de investigação em diversas mídias, música eletrônica, esculturas tecnológicas, instalações e performances, sempre realizadas com a implicação afetiva de amigos e colaboradores. Comemoramos os 30 anos do Chelpa Ferro no cenário artístico da arte contemporânea, inspirados pela habilidade de invenção que emerge quando as pessoas estão juntas. Palavras-chave:Experiências sonoras. Música eletrônica. Instalação. Hibridismos. Práticas coletivas. AbstractIn this interview conducted via Zoom on September 18, 2024, Chelpa Ferro members Sergio Mekler, Barrão and Luiz Zerbini talk about the moments and impulses that gave rise to the collective in the memorable CEP 20,000, in dialogue with their trajectories and with the desire to make music. The artists reflect on their experimental practices, discussing the operations of investigation in different media, electronic music, technological sculptures, installations and performances, always carried out with the affective involvement of friends and collaborators. We celebrate Chelpa Ferro’s 30 years in the artistic scene of contemporary art, inspired by the ability for invention that emerges when people are together. Keywords:Sound experiences. Electronic music. Installation. Hybridisms. Collective practices.
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Behrends, Jeff. "Normative Source and Extensional Adequacy." Journal of Ethics and Social Philosophy 10, no. 3 (2017): 1–26. http://dx.doi.org/10.26556/jesp.v10i3.103.
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Internalists about practical reasons maintain that all of an agent’s reasons for action derive their normative force via some relation in which they stand with that agent’s pro-attitudes, or the pro-attitudes that the agent would have in some idealized set of circumstances. One common complaint against internalism is that the view is extensionally inadequate – that it cannot render the correct verdicts about what reasons agents have in a range of important cases. In this paper, I examine that charge of extensional inadequacy, taking as my starting point an argument that Derek Parfit has recently leveled against internalism. Through a close evaluation of that argument and potential replies to it, I attempt to show that internalists cannot accommodate important pre-theoretical intuitions about what reasons we have. However, I also argue that Parfit’s case is importantly overstated; I set out to show that his argument cannot establish, as he thinks it does, that no reasons derive their normative force in the way that internalists believe that all do. In doing so, I draw attention to the possibility of a hybrid position about practical reasons that, surprisingly, receives little attention in the existing literature. If the arguments of the paper succeed, I will have established a modest theoretical advantage for hybridism over internalism – namely, that it is not vulnerable to the charge of extensional inadequacy. My hope is that this goes some way toward establishing hybridism’s credentials as a serious alternative to its “pure” competitors.
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Jiang, Bowen, and Yujing Liu. "A Hybrid Energy Storage System with Reconfigurability and Fast Equalisation." Power Electronics and Drives 7, no. 1 (2022): 68–83. http://dx.doi.org/10.2478/pead-2022-0006.
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Abstract With the rapid growth of electric vehicles (EVs) in recent years, the research on their energy storage systems (ESSs) has also shown great popularity. A traditional ESS normally has a fixed configuration and uses a single type of energy storage unit. However, this traditional design has some limitations, such as low flexibility and high requirements to unit consistency. To solve these problems, a new hybrid energy storage system is proposed in this paper. The proposed ESS hybridises multiple lithium-ion battery modules and one supercapacitor module. By controlling the states of switches inside the ESS topology, module level reconfiguration can be achieved. Further, a DC/DC converter is also included in the ESS topology, which is connected to the supercapacitor module and can be used to ensure correct ESS output voltage. Reconfiguration and active balancing algorithms are also given based on the proposed ESS topology. Situations with and without bypassing the lithium-ion battery modules are both discussed in the algorithms. The proposed hybrid ESS is finally verified with simulations. The system model is built in the Simulink/MATLAB environment. Simulation results show that the lithium-ion modules with a lower state of charge values have higher priorities to be connected in parallel. Reconfiguration actions are able to balance all lithium-ion battery modules within one Worldwide Harmonised Light-Duty Vehicle Test Cycle (WLTC) simulation cycle while maintaining ESS output voltage within a correct range. Furthermore, the proposed hybrid ESS control algorithms remain valid when one lithium-ion battery module is manually bypassed during simulation.
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Castillo, María L., Urs Schaffner, Purity R. Mbaabu, et al. "Following in the footsteps of invasion: comparisons of founder and invasive genotypes of two independent invasions reveal site-specific demographic processes and no influence by landscape attributes on dispersal." NeoBiota 93 (June 24, 2024): 263–91. https://doi.org/10.3897/neobiota.93.117457.
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To understand the success of invasive alien species, it is necessary to evaluate the site-specific eco-evolutionary challenges they face in their new environments. We explored whether the rearrangement of genetic diversity is linked to the invasiveness of <i>Prosopis juliflora</i> by (i) comparing different stages of invasion (founding vs invasive populations) in two invaded areas (Afar Region, Ethiopia and Baringo County, Kenya) to evaluate whether different stages are dominated by different genetic attributes (e.g., characteristic genotypes or levels of genetic diversity) and by (ii) evaluating if landscape features affected dispersal between invasive populations in the two invaded areas. We hypothesised that different invasion stages would have unique genetic characteristics due to either site-specific demographic and/or dispersal dynamics. We also compared the genetic characteristics at an 'invasive–non-invasive congener' level by studying the non-invasive <i>P. pallida</i>, introduced to Baringo County, and assessed whether it hybridises with <i>P. juliflora</i>. In the Afar Region, the establishment and spread of <i>P. juliflora</i> were characterised by extensive gene flow that homogenised genetic diversity across all populations. In contrast, in Baringo County, invasive populations had lower genetic diversity than founders, and genetic differentiation was lower between invasive populations than between invasive and founder populations. In both invaded areas, we found no evidence that dispersal was hampered by geographic distance, bioclimatic conditions, or distance to roads, rivers and villages, at least at the spatial scales of our study; indicating frequent long-distance dispersal. Allelic richness was higher in <i>P. juliflora</i> than <i>P. pallida</i> founders and hybrids were mainly planted trees probably resulting from the sympatric cultivation of the two species following their introduction. Thus, management actions on <i>Prosopis</i> invasion in eastern Africa should consider site-specific dynamics occurring during the invasion.
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Schätti, Beat, Christoph Kucharzewski, and Frank Tillack. "Platyceps rhodorachis (JAN, 1863) - a study of the racer genus Platyceps BLYTH, 1860 east of the Tigris (Reptilia: Squamata: Colubridae)." Vertebrate Zoology 64, no. 3 (2014): 297–405. http://dx.doi.org/10.3897/vz.64.e31498.
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Platyceps rhodorachis (Jan, 1863) is a euryoecious polytypic racer distributed from NE Iraq to Central Asia (Kyrgyzstan) and the Himalayas (probably westernmost Nepal). The nominotypical subspecies, occupying most of the species’ range, is polymorphic. The typical (striped) phenotype is absent from certain peripheral areas. Notable geographic variation is observed in the number of ventrals, subcaudals, dorsal scales, or maxillary teeth and in the colour pattern. P. r. ladacensis (Anderson, 1871) is only found from the eastern Hindu Kush into northern Himachal Pradesh (India). Its presence south of the Zanskar Range requires confirmation and the status of the Ladakh Cliff Racer is debatable. The identity and systematic position of racers from the vicinity of Ahvaz (Khuzestan) as well as Arabian and southern Red Sea populations commonly assigned to P. rhodorachis pend further investigation. Platyceps semifasciatus Blyth, 1860 is a senior subjective synonym of P. rhodorachis (nomen protectum, valid type species of Platyceps Blyth). P. ventromaculatus (Gray, 1834) from the Makran coast to low-lying NW India and Nepal, for a long time confused with Jan’s Cliff Racer (P. rhodorachis sensu stricto), is a mostly parapatric species. Two new taxa of the rhodorachis species group from montane NE Baluchistan Province (P. noeli sp. nov.) and the southern Indus Plain (P. sindhensis sp. nov.) are described. Another racer taxon from northern Azad Jammu and Kashmir remains undesignated. Distinctive morphological character states for P. rhodorachis vis-à-vis the southeast Mediterrano-Iranian P. najadum (Eichwald, 1831), P. karelini (Brandt, 1838) from Libya to the Lake Balqash area and inland SW Pakistan (hybridises in places with P. r. rhodorachis), Baluch endemics including P. mintonorum (Mertens, 1969), and Sindian species (sindhensis, ventromaculatus) are elaborated. An identification key embracing the Indian P. bholanathi (Sharma, 1976) and P. gracilis (Günther, 1862) as well as a review of Platyceps Blyth are provided. This genus is currently comprised of twenty-three mainly southern Palaearctic and Afrotropical as well as two Indian species referred to three (florulentus, najadum, rhodorachis-ventromaculatus) evolutionary lineages.
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Schätti, Beat, Christoph Kucharzewski, and Frank Tillack. "Platyceps rhodorachis (Jan, 1863) - a study of." Vertebrate Zoology 64 (December 5, 2014): 297–405. https://doi.org/10.3897/vz.64.e31498.
Full textAbstract:
Platyceps rhodorachis (Jan, 1863) is a euryoecious polytypic racer distributed from NE Iraq to Central Asia (Kyrgyzstan) and the Himalayas (probably westernmost Nepal). The nominotypical subspecies, occupying most of the species' range, is polymorphic. The typical (striped) phenotype is absent from certain peripheral areas. Notable geographic variation is observed in the number of ventrals, subcaudals, dorsal scales, or maxillary teeth and in the colour pattern. P. r. ladacensis (Anderson, 1871) is only found from the eastern Hindu Kush into northern Himachal Pradesh (India). Its presence south of the Zanskar Range requires confirmation and the status of the Ladakh Cliff Racer is debatable. The identity and systematic position of racers from the vicinity of Ahvaz (Khuzestan) as well as Arabian and southern Red Sea populations commonly assigned to P. rhodorachis pend further investigation. Platyceps semifasciatus Blyth, 1860 is a senior subjective synonym of P. rhodorachis (nomen protectum, valid type species of Platyceps Blyth). P. ventromaculatus (Gray, 1834) from the Makran coast to low-lying NW India and Nepal, for a long time confused with Jan's Cliff Racer (P. rhodorachis sensu stricto), is a mostly parapatric species. Two new taxa of the rhodorachis species group from montane NE Baluchistan Province (P. noeli sp. nov.) and the southern Indus Plain (P. sindhensis sp. nov.) are described. Another racer taxon from northern Azad Jammu and Kashmir remains undesignated. Distinctive morphological character states for P. rhodorachis vis-à-vis the southeast Mediterrano-Iranian P. najadum (Eichwald, 1831), P. karelini (Brandt, 1838) from Libya to the Lake Balqash area and inland SW Pakistan (hybridises in places with P. r. rhodorachis), Baluch endemics including P. mintonorum (Mertens, 1969), and Sindian species (sindhensis, ventromaculatus) are elaborated. An identification key embracing the Indian P. bholanathi (Sharma, 1976) and P. gracilis (Günther, 1862) as well as a review of Platyceps Blyth are provided. This genus is currently comprised of twenty-three mainly southern Palaearctic and Afrotropical as well as two Indian species referred to three (florulentus, najadum, rhodorachis-ventromaculatus) evolutionary lineages.
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Zini, Gina, Stefano Valentini, Pierluigi Puggioni, et al. "Detection of the BCR-ABL Fusion protein2 by Using the Abbott Cell Dyn Sapphire.a Routine Blood Hematology Analyser." Blood 114, no. 22 (2009): 4699. http://dx.doi.org/10.1182/blood.v114.22.4699.4699.
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Abstract Abstract 4699 Objectives We have evaluated the possibility to use the new BD Cytometric Bead Array to detect the presence of the BCR-ABL fusion protein2 in peripheral blood samples with a routine blood hematology analyser, the Abbott Cell-Dyn Sapphire, for a quick identification of those positive samples, both at diagnosis and at follow up to detect the MRD. This pilot study was carried out on 5 samples with different level of BCR-ABL fusion protein2 plus 2 control samples positive and negative respectively: results were compared with those obtained with the BD FACScanto and the standard FISH analysis reference method. Methods Flow cytometry allows for the discrimination of particles on the basis of attributes such as size and fluorescence. BD Cytometric Bead Array (CBA) systems provide a way of coupling a soluble analyte or set of analytes with beads of known size and fluorescence, making it possible to detect analytes through flow cytometry.1 The BD” BCR-ABL Protein Kit uses this technology to detect BCR-ABL fusion proteins2 in human blood research samples. Cell-Dyn Sapphire is a routine automated hematology analyzer for full blood count. Moreover the system employs immuno-fluorescence analysis technology, similar to that used on a dedicated fluorescence flow cytometer, for analysis of MAb applications. BD FacScant is a routine dedicated flow cytometer using 6 fluorescence channels. FISH (Fluorescence In Situ Hybridation) is a cytogenetic technique using fluorescent probes that bind to only those part of the chromosome with which they show a high degree of sequence similarity in interphase nuclei and on metaphase chromosome. FISH detects and localizes the presence, the absence or the translocation of specific DNA sequences on chromosomes. In this patients' category, LSI bcr/abl dual fusion DNA probe hybridises to chromosome 22q11.2 (breakpoint cluster region SpectrumGreen) and to chromosome 9q34 (abl oncogene SpectrumOrange). In interphase nuclei of normal cells, the probe signals generally appear as two distinct signals of each colour. In the pathological cells with bcr/abl translocation, individual orange and green signals from the normal 9 and 22 chromosome and two orange/green fusion signals (one each from the derivative 9 and 22 chromosomes) is observed. We have analysed 200 nuclei in fluorescence microscopy for each sample. Statistical analyses were performed using the MedCalc program comparing the median fluorescence values obtained by the 2 cytometers and with the standard diagnostic procedure. Results Correlation of median fluorescence data between the BD FACScanto and the CD Sapphire is excellent with a Correlation coefficient r = 1,0000 and a Significance level P<0,0001 (Fig 1). The Box –and –whisker Multiple comparison graph of the CD method versus the FISH reference one is represented in Figure 2. The results of our pilot study demonstrate the robustness of this new diagnostic tool in detecting the presence of the BCR-ABL fusion protein2 in the routine Laboratory of Hematology. The main limit to use this tool is now represented by the high cost of the BD Cytometric Bead Array. Disclosures: No relevant conflicts of interest to declare.
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Ergasheva, Dilnoza Xalbutayevna. "APRICOT BIOLOGY AND CULTIVATION TECHNOLOGY." Journal of Exercise Physiology 5 (July 23, 2022). https://doi.org/10.5281/zenodo.6892447.
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Kohtamäki, Vuokko. "Ammattikorkeakoulujen autonomian hybridisyys ylläpitäjähallinnon ja osakeyhtiöhallinnon konteksteissa." Tiedepolitiikka 49, no. 2 (2024). http://dx.doi.org/10.58957/tp.142713.
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Ammattikorkeakoulujen autonomiaa on Suomessa pyritty vahvistamaan lainsäädännöllä lähes koko ammattikorkeakoulujen olemassaoloajan. Autonomian ajallisina merkkipaaluina voidaan pitää ammattikorkeakoulujen alkuvaiheen ylläpitäjähallinnon aikaa ja sen jälkeistä yhtiöhallinnon aikaa. Ylläpitäjähallinnon aikakaudella ylläpitäjäjärjestelmä oli hallinnollinen ratkaisu ammattikorkeakoulujen perustamisvaiheesta aina vuoden 2014 ammattikorkeakoululakiin saakka. Tuolloin ammattikorkeakoulut toimivat osana ylläpitäjiensä (kuntien, kuntayhtymien, osakeyhtiöiden ja säätiöiden) hallintoa, taloutta ja organisaatiota. Ammattikorkeakoululain uudistuksen jälkeen siirryttiin kokonaan osakeyhtiöhallinnon aikakauteen. Tämä siirtymä tarkoitti sitä, että luopumalla ylläpitäjäjärjestelmästä ammattikorkeakouluista pyrittiin muodostamaan itsenäisiä taloudellis-hallinnollisia ja juridisia entiteettejä, jolloin niillä olisi enemmän päätösvaltaa omista asioistaan. Ammattikorkeakouluista tuli ammattikorkeakouluosakeyhtiöitä. Uusimpana käänteenä muutamiin ammattikorkeakouluosakeyhtiöihin ovat tulleet mukaan yliopisto-omistajat. Tämä katsausartikkeli tarkastelee aiempiin julkaisuihin perustuen suomalaisammattikorkeakoulujen autonomian muotoutumista ylläpitäjähallinnon ja osakeyhtiöhallinnon aikakausina. Johtopäätöksissä autonomiasta ja hallinnosta keskustellaan hybridiä hallintaa koskevan tutkimuskirjallisuuden avulla.
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Maluf, Renato S. "Decentralized food systems and eating in localities: a multi-scale approach." Revista de Economia e Sociologia Rural 59, no. 4 (2021). http://dx.doi.org/10.1590/1806-9479.2021.238782.
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Abstract: This article describes a systemic approach to analyzing issues related to food and eating, starting with a review of the different meanings and uses of the notions of food systems and agri-food chains. A systemic, multi-scale approach is developed to support the proposed notion of decentralized food systems in an attempt to account for the complementarities, conflicts, and hybridisms that result from the coexistence of distinct food systems in terms of modes of production and distribution, flows of goods, and the shaping of eating habits. Special attention is paid to localities and respective territories as analytical spheres, with the introduction of empirical evidence from two studies conducted in the Brazilian localities of Juazeiro (Bahia) and Chapecó (Santa Catarina).
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M.P.Ganesan and N.Moorthy. "Postcolonial Perspective in Salman Rushdie's Shalimar the Clown." June 15, 2019. https://doi.org/10.5281/zenodo.3269011.
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This Paper focuses on the postcolonial perspective in Salman Rushdie’s Shalimar the Clown and especially focuses on the main character of the novel, Shalimar. The rapid explanation is used to emphasize the different postcolonial propensity in the ctional village Pachigam, in Shalimar the Clown. This village Pachigam is a place of hybridists, uidity, and also a space marked by distinction. It is distinctive but not a smooth postcolonial space, one which Brennan ignores in his de nition of post colonialism. The paper describes essentially about the vague relationship of the village Pachigam, a microcosm of Kashmir with the larger ‘postcolonial’, ‘post-imperial’ entities of India and Pakistan. The paper also analyses the women’s sufferings, psychology and injustice in postcolonial India.
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Rodríguez, Jorge Antonio Sosa. "Corte Malandra memes and post-digital mediation of Venezuelan violence." Hybrid 13 (2025). https://doi.org/10.4000/13utd.
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For Venezuelans, the figure of Saint Malandro (delinquent or thug) embodies a particular relationship to violence that blends the imaginary of the delinquent from the barrios (slums or favelas) with popular religious practices. When spread through social media, this imaginary hybridises both digital and spiritual practices, notably in the form of memes. This article explores the post-digital implications of such memes by analyzing their socio-technical dynamics as a mode of mediating with violence. In doing so, we seek to advance the understanding of the complex cultural relationship that Venezuelans have with violence. We also aim to inquire to what extent the cultural and religious specificities of these images call for the articulation of certain aspects of memes as an anthropological concept (memetics) with those of memes as digital objects.
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Koski, Kaarina, and Riikka Turtiainen. "Vernakulaari verkossa." Elore 27, no. 1 (2020). http://dx.doi.org/10.30666/elore.88834.
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Vernakulaaria eli kansanomaista tai omaehtoista, instituutioiden ulkopuolella syntyvää kulttuuria on pitkään tarkasteltu valtakulttuurille vastakkaisena tai alisteisena. Digitaalisissa ympäristöissä vernakulaarin on huomattu olevan myös sekoittunutta eli hybridistä, kun kaupalliset alustat ovat itseilmaisun elinehto ja myös sisällöissä kierrätetään ja tulkitaan uudelleen ammattimaisesti tuotettuja kuvastoja. Samalla omaehtoinen toiminta saa myös yhä enemmän näkyvyyttä ja valtaa. Vernakulaari auktoriteetti on paitsi perinteen arvovaltaa ja vastakulttuurien voimaa, myös institutionaalisten toimijoiden tavoittelema ominaisuus. Vernakulaaria lähestytään tässä vertaisuutta ja omaehtoisuutta ilmaisevana rekisterinä, jolla erottaudutaan valtarakenteista. Etenkin sosiaalisessa mediassa myös yhtiöt, viranomaiset ja vallankäyttäjät lainaavat ja omaksuvat vernakulaareja genrejä ja trendejä lähestyessään suurta yleisöä. Tässä artikkelissa tarkastellaan vernakulaarin ulottuvuuksia ja vernakulaarin auktoriteetin muotoutumista digitaalisessa ympäristössä. Päähuomio on suomalaisissa some-vaikuttajissa vernakulaareina auktoriteetteina, joiden toiminnalle on ominaista hybridisyys ja vernakulaarin rekisterin taitava hallinta. Kaupallinen yhteistyö mahdollistaa monikanavaisen some-läsnäolon ja lisää some-vaikuttajan vernakulaaria auktoriteettia. Samalla on huolehdittava, etteivät kaupalliset intressit korostu liikaa vaan mielikuva vertaisuudesta ja aitoudesta säilyy.
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Caignard, Gael. "Performativité et habitation urbaine: itinéraires sonores dans la fragilité globale." Itinera, no. 25 (August 8, 2023). http://dx.doi.org/10.54103/2039-9251/20810.
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 This article aims to weave the fields of performativity, sound and urban living through philosophical itineraries that follow two motifs: mourning and vulnerability. Through Bonnie Honig's rereading of Antigone, we will trace the characters of a performative Antigone, who hybridises the fields of phoné and logos in her lament. We will then consider the example of contemporary mourning as well as the problem of urban soundscape spread by an ubiquitous technophony. We will address the motif of vulnerability starting from the work and research of Brandon Labelle, who will accompany us on sound walks where listening will emerge as a performative practice. Listening to urban space confronts us with a global and generalised vulnerability. By combining mourning and vulnerability, we will finally express the need for a performativity of fragility in our global condition.
 
 
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Coelho, Fred. "Improvisations of a Tropical Cartesianism." Critical Studies in Improvisation / Études critiques en improvisation 7, no. 1 (2011). http://dx.doi.org/10.21083/csieci.v7i1.1359.
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This article presents the contrasting views and theories formulated by European intellectuals such as Claude Lévis-Strauss and Max Bense on the situation of Brazil and Latin America in relation to the main centers of twentieth century criticism. It analyzes improvisation as a fundamental reflection index on the possibilities that third world countries have for negotiating the European Cartesian paradigm. If for some thinkers improvisation and its corollaries are proof that these countries and their people would live forever on the margins or in negative dialectics within the heritage of Enlightenment reason, for others it is precisely there--in the possibility of reinventing reason from hybridisms, strategic appropriations, and re-readings--that the creative and autonomous potentials in the post-colonial world lie. This article is situated precisely in the conflict between reason and the tropics, and looks to bring the debate up to date.
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Lambert, James. "A multitude of “lishes”." English World-Wide 38, no. 3 (2017). http://dx.doi.org/10.1075/eww.38.3.04lam.
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The present paper deals with portmanteau terms based on the word English, the bulk of which form a varied and extensive nomenclature used to describe hybrids of the English language with other languages. A citation database of over 3,500 entries was created containing 510 separate terms dating from the early 20th century to mid-2016. These figures indicate a widespread interest in the ways in which English hybridises with other languages and becomes localised in various parts of the globe. The results also show a trend of continuing increase in the coining of such terms to be expected in an increasingly globalised world. However, to date there has been no exhaustive examination of names for English-language hybrids. The present paper examines these portmanteau terms with regard to semantics, etymology, history, frequency, and pronunciation, and presents an alphabetical table of the complete set of terms in the Appendix.
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Michel, Christian. "A Hybrid Account of Concepts Within the Predictive Processing Paradigm." Review of Philosophy and Psychology, July 21, 2022. http://dx.doi.org/10.1007/s13164-022-00648-8.
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AbstractWe seem to learn and use concepts in a variety of heterogenous “formats”, including exemplars, prototypes, and theories. Different strategies have been proposed to account for this diversity. Hybridists consider instances in different formats to be instances of a single concept. Pluralists think that each instance in a different format is a different concept. Eliminativists deny that the different instances in different formats pertain to a scientifically fruitful kind and recommend eliminating the notion of a “concept” entirely. In recent years, hybridism has received the most attention and support. However, we are still lacking a cognitive-computational model for concept representation and processing that would underpin hybridism. The aim of this paper is to advance the understanding of concepts by grounding hybridism in a neuroscientific model within the Predictive Processing framework. In the suggested view, the different formats are not distinct parts of a concept but arise from different ways of processing a functionally unified representational structure.
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Roy, Sthitadhi, Ivan Khaymovich, Arnab Das, and Roderich Moessner. "Multifractality without fine-tuning in a Floquet quasiperiodic chain." SciPost Physics 4, no. 5 (2018). http://dx.doi.org/10.21468/scipostphys.4.5.025.
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Periodically driven, or Floquet, disordered quantum systems have generated many unexpected discoveries of late, such as the anomalous Floquet Anderson insulator and the discrete time crystal. Here, we report the emergence of an entire band of multifractal wavefunctions in a periodically driven chain of non-interacting particles subject to spatially quasiperiodic disorder. Remarkably, this multifractality is robust in that it does not require any fine-tuning of the model parameters, which sets it apart from the known multifractality of critical wavefunctions. The multifractality arises as the periodic drive hybridises the localised and delocalised sectors of the undriven spectrum. We account for this phenomenon in a simple random matrix based theory. Finally, we discuss dynamical signatures of the multifractal states, which should betray their presence in cold atom experiments. Such a simple yet robust realisation of multifractality could advance this so far elusive phenomenon towards applications, such as the proposed disorder-induced enhancement of a superfluid transition.
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Eric, Laurier. "The Graphic Transcript: poaching comic book grammar for inscribing the visual, spatial and temporal aspects of action." June 17, 2014. https://doi.org/10.5281/zenodo.259262.
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A brief review is presented of existing forms of transcription of talk that incorporate visual, spatial and temporal elements. The most common forms use text and a line-by-line based system and conversation analytic transcripts have been successful in making a number of other features of talk visible. The desire of geographers to draw upon video recordings and time-lapse photography have lead to time-series images being used to bring those visual materials into documents. The graphic transcript is proposed as an alternative form of transcription that hybridises the qualities and evidentiary criteria of the transcript with the representational conventions of the comic strip. The comic strip itself has recently been undergoing a period of experimentation and hybridisation with other forms. The graphic transcript brings together familiar comic strip features such as panels, guttering, speech bubbles and captions with the transcript's criteria of providing an evidentiary record of earlier events that is available for re-inspection and re-interpretation by other analysts.
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Uchiyama, Yuri, Mitsuko Nakashima, Satoshi Watanabe, et al. "Ultra–sensitive droplet digital PCR for detecting a low–prevalence somatic GNAQ mutation in Sturge–Weber syndrome." Scientific Reports 6, no. 1 (2016). http://dx.doi.org/10.1038/srep22985.
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Abstract Droplet digital PCR (ddPCR), a method for measuring target nucleic acid sequence quantity, is useful for determining somatic mutation rates using TaqMan probes. In this study, the detection limit of copy numbers of test DNA by ddPCR was determined based on Poisson distribution. Peptide nucleic acid (PNA), which strongly hybridises to target lesions, can inhibit target amplification by PCR. Therefore, by combination of PCR with PNA and ddPCR (PNA–ddPCR), the detection limit could be lowered. We reanalysed a somatic GNAQ mutation (c.548G > A) in patients with Sturge–Weber syndrome (SWS) using ddPCR and PNA–ddPCR. Importantly, among three patients previously found to be mutation negative by next–generation sequencing, two patients had the GNAQ mutation with a mutant allele frequency of less than 1%. Furthermore, we were able to find the same mutation in blood leukocyte or saliva DNA derived from four out of 40 SWS patients. Vascular anomalies and blood leukocytes originate from endothelial cells and haemangioblasts, respectively, which are both of mesodermal origin. Therefore, blood leukocytes may harbour the GNAQ mutation, depending on the time when the somatic mutation is acquired. These data suggest the possibility of diagnosis using blood DNA in some patients with SWS.
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Maestroni, Letizia, Pietro Butti, Vittorio Giorgio Senatore, and Paola Branduardi. "pCEC-red: a new vector for easier and faster CRISPR-Cas9 genome editing in Saccharomyces cerevisiae." FEMS Yeast Research, January 14, 2023. http://dx.doi.org/10.1093/femsyr/foad002.
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Abstract CRISPR-Cas9 technology is widely used for precise and specific editing of Saccharomyces cerevisiae genome to obtain marker-free engineered hosts. Targeted Double Strand Breaks (DSB) is controlled by a guide RNA (gRNA), a chimeric RNA containing a structural segment for Cas9 binding and a 20-mer guide sequence that hybridises to the genomic DNA target. Introducing the 20-mer guide sequence into gRNA expression vectors often requires complex, time-consuming and/or expensive cloning procedures. We present a new plasmid for CRISPR-Cas9 genome-editing in S. cerevisiae, pCEC-red. This tool allows i) to transform yeast with both Cas9 and gRNA expression cassettes in a single plasmid and ii) to insert the 20-mer sequence in the plasmid with high efficiency, thanks to Golden Gate Assembly and iii) a red chromoprotein-based screening to speed up the selection of correct plasmids. We tested genome-editing efficiency of pCEC-red by targeting the ADE2 gene. We chose three different 20-mer targets and designed two types of repair fragments to test pCEC-red for precision editing and for large DNA region replacement procedures. We obtained high efficiencies (close to 90%) for both engineering procedures, suggesting that the pCEC system can be used for fast and reliable marker-free genome editing.
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O’Sullivan, Owen P., and Nigel Eastman. "‘Out of the Penal System and into the Hospital Regime?’ Judicial Challenges in Sentencing Mentally Disordered Offenders and the Likely Impact of the 2020 Sentencing Council Guideline." Journal of Criminal Law, November 20, 2023. http://dx.doi.org/10.1177/00220183231216012.
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Mentally disordered offenders may be vulnerable yet also pose particular risk to the public. Achieving appropriate sentencing poses complex challenges for judges in properly determining culpability and punishment, protecting the public, and meeting any identified treatment needs of the defendant. With respect to all three elements there is likely to be necessary reliance upon psychiatric expertise. Despite much previous statutory guidance, there has not – until very recently – been available specific sentencing guidelines from the Sentencing Council (SC) to assist the judiciary in what is a profoundly difficult exercise. This review describes and considers the guidance available to the judiciary in the Crown Courts of England and Wales regarding the various disposal options – including that which ‘hybridises’ penal and treatment disposal – in addition to facilitating and properly limiting the role of expert evidence. A specific focus is on contextualising, and commenting upon, the SC's recently published Guidance, Sentencing Offenders with Mental Disorders, Developmental Disorders or Neurological Impairments, which seeks to consolidate information, improve knowledge, reduce confusion, and assist the courts towards properly and consistently addressing the relevance of mental disorder to sentencing. In doing so, in the authors’ view, it privileges punishment over public safety, leaving judges to address public safety largely without the benefit of the explicit ‘routes to sentencing’ approach of the Guidance.
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Malmberg, Anja. "Digital grammatik – grammatikövningar i läromedlens webbversioner." Acta Didactica Norden 17, no. 4 (2023). http://dx.doi.org/10.5617/adno.9801.
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I den här artikeln har grammatikövningarna i sex läromedels webbversioner undersökts för att diskutera hur grammatiklärandet förändras när klassrummet hybridiseras. Läromedelsutredningen (SOU 2021:71) konstaterar att webb-baserade läromedel blir allt vanligare och förlagen lyfter gärna fram att grammatikövningarna i böckernas webbversioner är självrättande. I artikeln har utformningen av alla övningar i läromedlens grammatikkapitel och språkriktighetskapitel undersökts. Dessutom har övningarna kategoriserats utifrån tre teman: vad som är övningens lärandeobjekt, vilket språkligt material eleven ges att öva på, och hur det grammatiska metaspråket används i övningen. Resultatet visar att de digitala övningarna härmar de övningsstrukturer som finns i tryckta läromedel. Den typiska övningen syftar till att lära eleven en specifik avgränsad grammatisk struktur. Den grammatiska strukturen övas genom att eleven pekar ut den i ett antal kontextlösa satser. Det grammatiska metaspråket behöver eleven egentligen aldrig själv använda, utan bara läsa och förstå. Detta står i skarp kontrast till den moderna grammatikdidaktiska forskningen som framför allt lyfter att elever behöver möta grammatiken i kontextualiserat språk och att eleverna i samtal själva behöver använda metaspråket (Myhill et al., 2012a; Newman & Watson, 2020). Läromedlen har inte heller didaktiskt designats för att fungera i ett hybridiserat klassrum (Holm Sørensen & Tweddell Levinsen, 2019), utan använder samma didaktik som i de fysiska böckerna. De självrättande övningarna ger i och för sig snabb återkoppling, men fungerar inte när det finns flera möjliga lösningar.
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Faria, Alexandre. "CO-PRODUCTION OF MANAGEMENT KNOWLEDGE IN/FROM EMERGING COUNTRIES AND SOCIETIES." Revista de Administração de Empresas 63, no. 1 (2023). http://dx.doi.org/10.1590/s0034-759020230108x.
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ABSTRACT In an era of decolonization and empire, the management field embraced the US-led neoliberal counterrevolution and challenged the Eurocentric theory-practice hierarchy to produced relevant knowledge through managed learning theories. This contested reformist and market-centric management revolution (MR) against the threat of “reverse relevance” fostered by emerging/resurging barbarians subalternizes Southern theories-practices of the multifaceted field of development administration-management (DA) and de-develops the global majority by privileging large corporations and transnational elites. MR expanded in the 1990s through a post-Washington Consensus social perspective based on re-Westernalizing whitening appropriation-containment dynamics of developmental neoliberalisms and Southern counter-hegemonic movements informed by dewesternization and decolonial dynamics which challenge-reaffirm racial capitalism structures. In an Age of Development, MR was re-organized in the 2000s in response to “irresponsible” hybridisms in emerging countries and societies triggered by Southern learning-unlearning-relearning dynamics. This article investigates the Southern co-production of relevant knowledge in Brazil through subversive complicity, focused on a privileged organization-school nexus. Analysis shows how managers and researchers (re)mobilize Southern theories-practices to co-produce relevant knowledge from a transformational-reformist perspective. In the end, the article presents discussions and suggestions for collectively re-appropriating Southern relevant knowledge engaged with the ‘other’ in emerging/resurging societies in both the South and North.
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Maia, Midierson. "Moda e publicidade no Brasil: uma relação histórica permeada por hibridismos // Fashion and advertisement in Brazil: a historical relation permeated by hybridisms - DOI: 10.5752/P.2237-9967.2013v2n1p61." Dispositiva 2, no. 1 (2013). http://dx.doi.org/10.5752/p.2237-9967.2013v2n1p61.
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Linan, Alexander G., Rebecca Sucher, Alanna Sanders, et al. "Preserving Wild Pears: Using Genomic Data to Assess Species Boundaries, Interspecific Hybridization, and Genetic Diversity to Inform Conservation." Molecular Ecology, June 13, 2025. https://doi.org/10.1111/mec.17813.
Full textAbstract:
ABSTRACTWild congeners of cultivated fruit trees are vital sources of genetic diversity for crop improvement and key targets for conservation. However, cultivating crops within the range of rare wild congeners increases the risk of interspecific hybridization, threatening the genomic integrity of wild species. This is a concern for Pyrus in Central Asia, where a critically endangered wild species, P. korshinskyi, coexists with cultivated Pyrus communis and another widespread species, P. regelii, forming a species complex in which species boundaries are unclear, complicating conservation efforts. Here, we sought to assess: (1) the distinctiveness of species, (2) the extent to which interspecific hybridization and introgression may reduce the genetic integrity of P. korshinskyi, and (3) genetic diversity and structure within P. korshinskyi. Using RAD sequencing to genotype 185 individuals from 13 presumed wild and ex situ populations in Kyrgyzstan, we found that P. korshinskyi is genetically distinct, highly morphologically variable, but occasionally hybridises with both P. regelii and P. communis. Morphometric analyses indicate that the parental species and hybrids can be differentiated based on leaf characters. Unexpectedly, several reportedly wild populations of P. korshinskyi were found to be clonally propagated; unfortunately, because Pyrus exhibits gametophytic self‐incompatibility and all of the trees are the same genotype, these propagated populations are mate limited, limiting their conservation value. While P. korshinskyi populations are genetically diverse, further efforts are needed to preserve wild genetic diversity ex situ. These findings guide conservation strategies to maintain genetic integrity and diversity of P. korshinskyi both in situ and ex situ, underscoring the importance of genetic analyses for conserving crop wild relatives, especially in complex cultivated‐wild mosaics.