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Journal articles on the topic 'Hydantoin derivatives'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 July 2025

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1

Wadghane, Somnath, Rohit Bhor, Ganesh Shinde, Mahesh Kolhe, and Pooja Rathod. "A Review on the Some Biological Activities of the Hydantoin Derivatives." Journal of Drug Delivery and Therapeutics 13, no. 1 (2023): 171–78. http://dx.doi.org/10.22270/jddt.v13i1.5904.

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Hydantoin derivatives are commonly used anticonvulsants. In general, they are effective for partial-onset seizures and tonic-clonic seizures, but not for absence seizures. Phenytoin is the most important drug in this group, and other drugs, ethotoin, and mephenytoin, are also commonly used to treat epilepsy. Prodrugs such as derivatives have been created. Phenytoin is effective in some cases of trigeminal neuralgia and related neuralgia. Phenytoin is also used to treat arrhythmias. Hydantoins or glycolylureas are heterocyclic organic compounds with the formula CH2C(O)NHC(O)NH. It is a colorles

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2

Šmit, Biljana, Ivana Radojević, Petar Stanić, Darko Ašanin, Marijana Vasić, and Jelena Katanić-Stanković. "Synthesis of series of different imidazolidine-2,4-dione derivatives and evaluation of their antimicrobial potential." Kragujevac Journal of Science, no. 44 (2022): 57–74. http://dx.doi.org/10.5937/kgjsci2244057s.

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A series of twenty two different imidazolidine-2,4-dione derivatives, divided according to their structure into five groups, including alkyl, alkenyl or aryl 5,5disubstituted hydantoins, spirohydantoins, and fused bicyclic and tricyclic hydantoins, was synthesized and examined for in vitro antimicrobial activity against 15 strains of bacteria and 4 strains of yeast. The antimicrobial activity was evaluated by the determination of the minimal inhibitory concentration (MIC) and the minimal microbicidal concentration (MMC) using the microdilution method. The assayed compounds exerted moderate ant

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3

López-López, Lluvia Itzel, Denisse de Loera, Ernesto Rivera-Avalos, and Aidé Sáenz-Galindo. "Green Synthesis of Hydantoins and Derivatives." Mini-Reviews in Organic Chemistry 17, no. 2 (2020): 176–84. http://dx.doi.org/10.2174/1570193x16666181206100225.

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The hydantoin moiety is found in several bioactive compounds with important pharmacological properties such as antimicrobial, antifungal, anti-androgens, anticancer and the historical action anticonvulsant. Because of these reasons, the synthesis of these compounds and their derivatives is important to review considering the philosophy of the green chemistry. In this review, we present the actual importance in the green synthesis of hydantoins and their derivatives using green methods, such as microwave and ultrasound irradiation, ionic liquids, solid-phase and solvent-free synthesis. Finally,

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4

Ganchev, Donyo, Marin Marinov, Stefan Krustev, Milena Zlateva, Nadezhda Atanasova, and Neyko Stoyanov. "PHYTOTOXICOLOGICAL STUDY OF SOME SPIROHYDANTOINS AND THEIR DERIVATIVES TOWARDS PSEUDOCROSSIDIUM REVOLUTUM." Journal scientific and applied research 3, no. 1 (2013): 20–25. http://dx.doi.org/10.46687/jsar.v3i1.58.

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This article presents a novel ecotoxicological investigation of probable deleterious effect of cyclopentanespiro-5-hydantoin, cyclohexanespiro-5-hydantoin, cyclopentanespiro-5-(2,4-dithiohydantoin) and 1-aminocyclopentanecarboxylic acid towards some of the most widespread moss species in the World – Pseudocrossidium revolutum.. Dose-response modeling was carried out by R language for Statistical Computing, drc package.

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5

Yu, Fang-Lei, Carl H. Schwalbe, and David J. Watkin. "Hydantoin and hydrogen-bonding patterns in hydantoin derivatives." Acta Crystallographica Section C Crystal Structure Communications 60, no. 10 (2004): o714—o717. http://dx.doi.org/10.1107/s0108270104017706.

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6

Bhadreshkumar. R. Sudani. "The Multifaceted Biological Activities of Hydantoin Derivatives: From Antimicrobial to Anticancer Agents." Bioscan 19, Supplement 2 (2024): 88–92. http://dx.doi.org/10.63001/tbs.2024.v19.i02.s2.pp88-92.

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Hydantoin derivatives, a versatile class of heterocyclic compounds, have garnered significant attention in recent years due to their diverse biological activities. These derivatives exhibit a wide range of pharmacological properties, making them valuable candidates in the development of therapeutic agents. This review highlights the multifaceted biological activities of Hydantoin derivatives, with a focus on their antimicrobial and anticancer properties. The antimicrobial efficacy of these compounds encompasses activity against various bacterial, fungal, and viral pathogens, presenting them as

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7

Shabnam Babu Shaikh, Rohit Jaysing Bhor, Amol Sopanrao Dighe, and Mahesh Hari Kolhe. "Novel new research strategies of hydantoin derivatives: A review." International Journal of Scholarly Research in Biology and Pharmacy 2, no. 1 (2023): 010–14. http://dx.doi.org/10.56781/ijsrbp.2023.2.1.0011.

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A non-aromatic five membered heterocycle known as hydantoin, imidazolidine-2,4-dione, is regarded as a desirable, preferred scaffold in medicinal chemistry. In addition to phenytoin, Nitrofurantoin, and Enzalutamide, the importance of the hydantoin scaffold in drug discovery has been supported by a number of medications currently in use. Hydantoin has two hydrogen bond acceptors and two hydrogen bond donors among its five possible substituent sites. Because they display a variety of biological and pharmacological activity in therapeutic and agrochemical applications, hydantoin and the hybrids

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8

Hanessian, Stephen, Rui-Yang Yang, and Jean-Yves Sancéau. "Synthesis of 1-N-hydroxyhydantoin 5-phosphates as potential fungicides." Canadian Journal of Chemistry 75, no. 6 (1997): 712–15. http://dx.doi.org/10.1139/v97-085.

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Two hydantoin analogs were synthesized utilizing an organometallic allylation reaction in aqueous solution as a key step. One of the derivatives showed weak fungicidal activity. Keywords: hydantoin, fungicide, phosphate.

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9

ASAKAWA, Takanobu, and Somei YARITA. "Noncyanide Silver Plating Solution Using Hydantoin and Hydantoin Derivatives." Journal of the Surface Finishing Society of Japan 50, no. 1 (1999): 68–71. http://dx.doi.org/10.4139/sfj.50.68.

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10

Trisovic, Nemanja, Gordana Uscumlic, and Slobodan Petrovic. "Hydantoins: Synthesis, properties and anticonvulsant activity." Chemical Industry 63, no. 1 (2009): 17–31. http://dx.doi.org/10.2298/hemind0901017t.

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Hydantoin is a five-membered cyclic ureide that is present in numerous biologically active compounds including antiarrhytmics, anticonvulsants and antitumor agents. This paper describes different ways of synthesis of hydantoin-derivatives, their physical properties and reactivity. Also, the most widely used hydantoin anticonvulsants and the analysis of structureactivity relationships of anticonvulsant drugs in terms of lipophilicity and hydrogen bonding are presented here.

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11

Divjak, Natalija, Nebojsa Banjac, Natasa Valentic, and Gordana Uscumlic. "Synthesis, structure and solvatochromism of 5-methyl-5-(3-or 4-substituted phenyl)hydantoins." Journal of the Serbian Chemical Society 74, no. 11 (2009): 1195–205. http://dx.doi.org/10.2298/jsc0911195d.

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Several 5-methyl-5-(3- or 4-substituted phenyl)hydantoins were prepared and their ultraviolet absorption spectra were recorded in the region 200-400 nm in twelve solvents of different polarity. The effect of solvent dipolarity/ polarizability and solvent/solute hydrogen bonding interactions were analyzed by means of the linear solvation energy relationship (LSER) concept proposed by Kamlet and Taft. The lipophilic activity of the investigated hydantoins was estimated by calculation of log P values with Advanced Chemistry Development Software. The calculated values of log P were correlated with

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12

Kaválek, Jaromír, Vladimír Macháček, Gabriela Svobodová, and Vojeslav Štěrba. "Base catalyzed cyclization of substituted esters of hydantoic and thiohydantoic acids." Collection of Czechoslovak Chemical Communications 51, no. 2 (1986): 375–90. http://dx.doi.org/10.1135/cccc19860375.

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Base catalyzed cyclization rates have been measured of 22 derivatives of hydantoic and thiohydantoic acid esters in water and methanol. The cyclization of methyl and ethyl esters of hydantoic and 5-methylhydantoic acids is accompanied by hydrolysis of the ester group, whereas with the other derivatives the hydrolysis does not take place. Hydrolysis of the cyclization products (hydantoin and thiohydantoin derivatives) is not significant under the kinetic conditions. The cyclization of methyl ester of 5-phenylhydantoic acid in methanol is reversible; the equilibrium mixture contains 30% of the s

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13

Abadi, Ashraf H., Jochen Lehmann, Gary A. Piazza, Mohammad Abdel-Halim та Mohamed S. M. Ali. "Synthesis, Molecular Modeling, and Biological Evaluation of Novel Tetrahydro-β-Carboline Hydantoin and Tetrahydro-β-Carboline Thiohydantoin Derivatives as Phosphodiesterase 5 Inhibitors". International Journal of Medicinal Chemistry 2011 (23 лютого 2011): 1–9. http://dx.doi.org/10.1155/2011/562421.

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Two series of fused tetrahydro-β-carboline hydantoin and tetrahydro-β-carboline thiohydantoin derivatives with a pendant 2,4-dimethoxyphenyl at position 5 were synthesized, and chiral carbons at positions 5 and 11a swing from R,R to R,S, S,R, and S,S. The prepared analogues were evaluated for their capacity to inhibit phosphodiesterase 5 (PDE5) isozyme. The R absolute configuration of C-5 in the β-carboline hydantoin derivatives was found to be essential for the PDE5 inhibition. Chiral carbon derived from amino acid even if of the S configuration (L-tryptophan) may lead to equiactive or more a

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14

Naik, Ravi S. "Synthesis and Spectral Studies of Hydantoin Derivativatives of Imidazo [2,1-b][1,3,4] Thiadiazoles." International Journal for Research in Applied Science and Engineering Technology 10, no. 2 (2022): 1270–71. http://dx.doi.org/10.22214/ijraset.2022.40510.

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Abstract: The present article describes the synthesis of Imidazo[2,1-b][1,3,4]thiadiazoles bearing pharmacologically important hydantoin molecules. To synthesize the targeted molecules several imidazothiadiazoles were prepared by condensation of 2- Amino-5-(4-fluorobenzyl)-1,3,4thiadiazole with phenacyl bromides. Which were subsequently subjected to Knoevenagel condensation to afford the hydantoin derivatives. Structures of newly synthesized molecules were confirmed by IR, NMR and Mass spectral studies. Keywords: Thiadiazole, Imidazothiadiazole, hydantoin, Vilsmeier Haack reaction

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15

N. Marinov, Marin. "ECOTOXICOLOGICAL EXAMINATION OF ACUTE TOXICITY OF SOME SPIROHYDANTOINS AND THEIR DERIVATIVES TOWARDS SEA LETTUCE (ULVA LACTUCA)." Journal scientific and applied research 2, no. 1 (2012): 74–81. http://dx.doi.org/10.46687/jsar.v2i1.46.

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This article presents an ecotoxicological study of acute toxicity deleterious effect of cyclopentanespiro-5-hydantoin, cyclohexanespiro-5-hydantoin, cyclopentanespiro-5-(2,4-dithiohydantoin) and 1-aminocyclopentanecarboxylic acid towards Sea lettuce (Ulva lactuca) conducted in accordance with international standards adopted by the Organisation for Economic Co-operation and Development (OECD). Dose-response modeling was carried out by R language for Statistical Computing, drc package.

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16

Ahmad, Roshan, Rukhsana Jabeen, Mohammad Zia-ul-Haq, Humaira Nadeem, Helmut Duddeck, and Eugen J. Verspohl. "Chiral Aryl Sulfonyl Hydantoins as Hypoglycemic Agents." Zeitschrift für Naturforschung B 55, no. 2 (2000): 203–7. http://dx.doi.org/10.1515/znb-2000-0212.

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Some novel chiral sulfonyl hydantoin derivatives 2a-e and 3 a-e have been prepared. p-Toluenesulfonyl chloride on treatment with L-amino acids in presence of K2CO3/H2O yielded N-(p-toluensulfonyl-)amino acids 1a - e which were cyclized in presence of NH4-SCN Ac2O to afford 1-(p-toluenesulfonyl)-5-substituted-2-thiohydantoins 2a-e. These compounds were oxidized with HNO3 to yield 1-(p-toluenesulfonyl)-5-substituted hydantoins 3a-e. The enantiomeric ratios of 3a-e were determined by 1H NMR spectroscopy using Eu(hfc)3. The antidiabetic activity of 3a-d has been determined.

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17

Ganchev, Donyo. "TOXICITY RESEARCH OF SOME SPIROHYDANTOIN DERIVATIVES TOWARDS LUMBRICUS TERRESTRIS." Journal Scientific and Applied Research 10, no. 1 (2016): 30–38. http://dx.doi.org/10.46687/jsar.v10i1.203.

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This paper presents an ecotoxicological examination of cyclopentanespiro-5-hydantoin, cyclopentanespiro-5-(2,4-dithiohydantoin) and 1-aminocyclopentane-1-carboxylic acid towards Lumbricus terrestris – the common earthworms which are extremely important for the ecological stability and fertility of soils.

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18

Jurin, Mladenka, Ana Čikoš, Višnja Stepanić, et al. "Synthesis, Absolute Configuration, Biological Profile and Antiproliferative Activity of New 3,5-Disubstituted Hydantoins." Pharmaceuticals 17, no. 10 (2024): 1259. http://dx.doi.org/10.3390/ph17101259.

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Hydantoins, a class of five-membered heterocyclic compounds, exhibit diverse biological activities. The aim of this study was to synthesize and characterize a series of novel 3,5-disubstituted hydantoins and to investigate their antiproliferative activity against human cancer cell lines. The new hydantoin derivatives 5a–i were prepared as racemic mixtures of syn- and anti-isomers via a base-assisted intramolecular amidolysis of C-3 functionalized β-lactams. The enantiomers of syn-5a and anti-hydantoins 5b were separated by preparative high-performance liquid chromatography (HPLC) using n-hexan

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19

Lazic, Anita, Natasa Valentic, Nemanja Trisovic, Slobodan Petrovic, and Gordana Uscumlic. "Synthesis, structure and biological properties of active spirohydantoin derivatives." Chemical Industry 70, no. 2 (2016): 177–99. http://dx.doi.org/10.2298/hemind150205025l.

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Spirohidantoins represent an pharmacologically important class of heterocycles since many derivatives have been recognized that display interesting activities against a wide range of biological targets. First synthesis of cycloalkanespiro-5-hydantoins was performed by Bucherer and Lieb 1934 by the reaction of cycloalkanone, potassium cyanide and ammonium-carbonate at reflux in a mixture of ethanol and water. QSAR (Quantitative Structure-Activity Relationship) studies showed that a wide range of biological activities of spirohydantoin derivatives strongly depend upon their structure. This paper

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20

Bhusainahalli, Vedamurthy M., Antonio Rescifina, Nunzio Cardullo, Carmela Spatafora, and Corrado Tringali. "Bio-activated intramolecular anti-aza-Michael addition: stereoselective synthesis of hydantoin derivatives." New Journal of Chemistry 42, no. 22 (2018): 18348–57. http://dx.doi.org/10.1039/c8nj02909a.

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21

Podešva, Jiří, Miroslava Dušková Smrčková, and Olga Trhlíková. "Role of Hydantoin Derivatives in Syntheses of Polyaspartates." Chemické listy 116, no. 4 (2022): 215–22. http://dx.doi.org/10.54779/chl20220215.

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Polyaspartates are industrially important resins formed by reactions of N-substituted 2‑aminosuccinates (or, synonymously, N-substituted aspartates) with isocyanates. To obtain sufficiently crosslinked networks, applicable as coatings, bis-aspartates with two secondary NH groups and isocyanates with more than two NCO groups in their molecules must be used. There are two major problems connected with these preparations: (i) bis-aspartates which are mostly synthesized by the aza-Michael addition of NH2 groups of a suitable diamine to C=C bonds of a maleate ester almost always contain a certain a

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22

Fujisaki, Fumiko, Hatsumi Aki, Ayumi Naito, et al. "Synthesis of New 5-Substituted Hydantoins and Symmetrical Twin-Drug Type Hydantoin Derivatives." Chemical and Pharmaceutical Bulletin 62, no. 5 (2014): 429–38. http://dx.doi.org/10.1248/cpb.c14-00017.

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23

Kucwaj-Brysz, Katarzyna, Rafał Kurczab, Ewa Żesławska, et al. "The role of aryl-topology in balancing between selective and dual 5-HT7R/5-HT1A actions of 3,5-substituted hydantoins." MedChemComm 9, no. 6 (2018): 1033–44. http://dx.doi.org/10.1039/c8md00168e.

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24

Marinov, Marin. "SYNTHESIS OF AMINO DERIVATIVES OF MONOTHIO- AND DITHIO- ANALOGUES OF CYCLOHEXANESPIRO-5-HYDANTOIN." Journal scientific and applied research 2, no. 1 (2012): 66–73. http://dx.doi.org/10.46687/jsar.v2i1.45.

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This article presents methods for synthesis of 3-amino derivatives of cyclohexanespiro-5-(2-thiohydantoin) and cyclohexanespiro-5-(2,4-dithiohydantoin). It was found out that the treatment of cyclohexanespiro-5-(2-thiohydantoin) with hydrazine hydrate under different reaction conditions led to obtaining of 3-amino derivative and 2-hydrazone of the initial compound. As a result of thionation of 3-aminocyclohexanespiro-5-hydantoin with P4S10 or Lawesson’s reagent, the corresponding dithio-analogue was synthesized. The structures of the products obtained were verified by IR, 1H NMR, 13C NMR and m

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25

Potdar, Shweta, Nikita Pal, Pratibha Sharma, and Ashok Kumar. "The catalytic influence of phosphotungstic acid-functionalized Fe3O4 MNPs blended with TiO2 on the synthesis of novel spiro-acridines and the evaluation of their medicinal potential through molecular docking studies." RSC Advances 10, no. 72 (2020): 44442–52. http://dx.doi.org/10.1039/d0ra06975b.

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This manuscript describes an effective and rapid three-component synthesis of a novel series of spiro-acridine derivatives by integrating the pharmacologically dynamic hydantoin–phenytoin as the prime synthetic equivalent.

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26

Gawas, Pratiksha P., Buthanapalli Ramakrishna, N. Veeraiah, and Venkatramaiah Nutalapati. "Multifunctional hydantoins: recent advances in optoelectronics and medicinal drugs from Academia to the chemical industry." Journal of Materials Chemistry C 9, no. 46 (2021): 16341–77. http://dx.doi.org/10.1039/d1tc04090a.

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This review provides a detailed survey on the structural modifications of hydantoin (TH)/2-thiohydantoin (2TH) derivatives and understanding of their photophysical properties, enabling their potential use in optoelectronics and prototypes.

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27

Volonterio, Alessandro, Maria Bellucci, Massimo Frigerio, and Tommaso Marcelli. "Multicomponent Synthesis of N-Carbamoyl Hydantoin Derivatives." Synlett 24, no. 06 (2013): 727–32. http://dx.doi.org/10.1055/s-0032-1318432.

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28

Su, Ma, Donglin Xia, Peng Teng, et al. "Membrane-Active Hydantoin Derivatives as Antibiotic Agents." Journal of Medicinal Chemistry 60, no. 20 (2017): 8456–65. http://dx.doi.org/10.1021/acs.jmedchem.7b00847.

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29

Oh, Chang-Hyun, Ki-Soo Lee, Eun-Joo Roh, Soon-Kyung Kwon, and Jung-Hyuck Cho. "Synthesis of new hydantoin-3-ethanethiol derivatives." Archives of Pharmacal Research 17, no. 4 (1994): 281–83. http://dx.doi.org/10.1007/bf02980462.

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30

Jakšea, Renata, Vesna Krošelj, Simon Rečnik, et al. "Stereoselective Synthesis of 5-[(Z)-Heteroarylmethylidene] Substituted Hydantoins and Thiohydantoins as Aplysinopsin Analogs." Zeitschrift für Naturforschung B 57, no. 4 (2002): 453–59. http://dx.doi.org/10.1515/znb-2002-0411.

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3-Substituted 5-[(Z)-heteroarylmethylidene]imidazolidine-2,4-dione and 5-[(Z)-heteroarylmethylidene]- 2-thiooxoimidazolidin-4-one derivatives were prepared stereoselectively by coupling of 5-(dimethylamino)methylidene substituted hydantoin and thiohydantoin derivatives with carbocyclic and heterocyclic C-nucleophiles.Configuration around the exocyclic C=C double bond was determined by NMR, using NOESY and 2D HMBC techniques.

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31

Bolla, Ratna Sekhar, Narasimha Murthy Gandikota та Ivaturi Venkata Kasi Viswanath. "Synthesis of Deuterium Labeled 5, 5-Dimethyl-3-(α, α, α-trifluoro-4-nitro-m-tolyl) Hydantoin". Current Radiopharmaceuticals 12, № 1 (2019): 82–87. http://dx.doi.org/10.2174/1874471012666181130162731.

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Objective: Stable and non-radioactive isotope labeled compounds gained significance in recent drug discovery and other various applications such as bio-analytical studies. The modern bioanalytical techniques can study the adverse therapeutic effects of drugs by comparing isotopically labeled internal standards. A well-designed labeled compound can provide high-quality information about the identity and quantification of drug-related compounds in biological samples. This information can be very useful at key decision points in drug development. In this study, we tried to synthesize Nilutamide-

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32

Fujisaki, Fumiko, Hatsumi Aki, Ayumi Naito, et al. "ChemInform Abstract: Synthesis of New 5-Substituted Hydantoins and Symmetrical Twin-Drug Type Hydantoin Derivatives." ChemInform 45, no. 43 (2014): no. http://dx.doi.org/10.1002/chin.201443126.

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33

Subhi, Hanan Tariq, Hiwa Ramadhan Fatah, and Hanaa Ali Muhammad. "Effect of New 2-Thioxoimidazolidin-4-one Compounds against Staphylococcus aureus Clinical Strains and Immunological Markers’ Combinations." Canadian Journal of Infectious Diseases and Medical Microbiology 2022 (July 13, 2022): 1–18. http://dx.doi.org/10.1155/2022/6720241.

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Although the structure-activity relationship indicates that the 4-thioxoimidazolidin ring is essential for antibacterial activities and pharmaceutical applications, there were no enough studies on the derivatives of this compound. Evaluating the new hydantoin compounds C5 (3-((2-bromobenzylidene) amino)-2- thioxoimidazolidin-4-one) and C6 (3-((4- methoxybenzylidene) amino)-2-thioxoimidazolidin-4-one) that were prepared against clinical Staphylococcus aureus isolates for antibacterial, antibiofilm, and antihemagglutination activities is the aim of this study. Therefore, the potential clinical r

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34

Witek, Karolina, Gniewomir Latacz, Aneta Kaczor, et al. "Phenylpiperazine 5,5-Dimethylhydantoin Derivatives as First Synthetic Inhibitors of Msr(A) Efflux Pump in Staphylococcus epidermidis." Molecules 25, no. 17 (2020): 3788. http://dx.doi.org/10.3390/molecules25173788.

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Herein, 15 phenylpiperazine 3-benzyl-5,5-dimethylhydantoin derivatives (1–15) were screened for modulatory activity towards Msr(A) efflux pump present in S. epidermidis bacteria. Synthesis, crystallographic analysis, biological studies in vitro and structure–activity relationship (SAR) analysis were performed. The efflux pump inhibitory (EPI) potency was determined by employing ethidium bromide accumulation assay in both Msr(A) efflux pump overexpressed (K/14/1345) and deficient (ATCC 12228) S. epidermidis strains. The series of compounds was also evaluated for the capacity to reduce the resis

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35

Georgieva, Stela, Petar Todorov, Jana Tchekalarova, et al. "Chemical Behavior and Bioactive Properties of Spinorphin Conjugated to 5,5′-Dimethyl- and 5,5′-Diphenylhydantoin Analogs." Pharmaceuticals 17, no. 6 (2024): 770. http://dx.doi.org/10.3390/ph17060770.

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The discovery of new peptides and their derivatives is an outcome of ongoing efforts to identify a peptide with significant biological activity for effective usage as a possible therapeutic agent. Spinorphin peptides have been documented to exhibit numerous applications and features. In this study, biologically active peptide derivatives based on novel peptide analogues of spinorphin conjugated with 5,5′-dimethyl (Dm) and 5,5′-diphenyl (Ph) hydantoin derivatives have been successfully synthesized and characterized. Scanning electron microscopy (SEM) and spectral methods such as UV-Vis, FT-IR (

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36

Chylińska, Marta, Marta Ziegler-Borowska, Halina Kaczmarek, Aleksandra Burkowska, Maciej Walczak, and Przemysław Kosobucki. "Synthesis and biocidal activity of novel N-halamine hydantoin-containing polystyrenes." e-Polymers 14, no. 1 (2014): 15–25. http://dx.doi.org/10.1515/epoly-2013-0010.

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AbstractThree homopolymers containing hydantoin substituents were obtained by chemical modification of reactive p-chloromethylated polystyrene. The prepared polymers were chlorinated to yield N-halamine materials with biocidal properties. The chemical structure of polymers was characterized by Fourier transform infrared spectroscopy and nuclear magnetic resonance spectroscopy. All of the hydantoin polymers are insoluble in water and common organic solvents. Microbiological investigations prove the high biocidal activity of the obtained chlorinated polystyrene derivatives containing spirohydant

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37

OHTANI, Yutaka, Takashi SAITO, Kenji SUGAWARA, et al. "Coordination Equilibria of Hydantoin Derivatives with Gold Ions." Journal of The Surface Finishing Society of Japan 56, no. 8 (2005): 479–80. http://dx.doi.org/10.4139/sfj.56.479.

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38

Bichel, Jørgen. "Hydantoin Derivatives and Malignancies of the Haemopoietic System." Acta Medica Scandinavica 198, no. 1-6 (2009): 327–28. http://dx.doi.org/10.1111/j.0954-6820.1975.tb19550.x.

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39

Colacino, Evelina, Frédéric Lamaty, Jean Martinez, and Isabelle Parrot. "Microwave-assisted solid-phase synthesis of hydantoin derivatives." Tetrahedron Letters 48, no. 30 (2007): 5317–20. http://dx.doi.org/10.1016/j.tetlet.2007.05.084.

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Kieć-Kononowicz, K., and E. Szymańska. "Antimycobacterial activity of 5-arylidene derivatives of hydantoin." Il Farmaco 57, no. 11 (2002): 909–16. http://dx.doi.org/10.1016/s0014-827x(02)01292-2.

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Kochetkov, Konstantin A., Olga N. Gorunova, and Natalia A. Bystrova. "Biologically Oriented Hybrids of Indole and Hydantoin Derivatives." Molecules 28, no. 2 (2023): 602. http://dx.doi.org/10.3390/molecules28020602.

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Indoles and hydantoins are important heterocycles scaffolds which present in numerous bioactive compounds which possess various biological activities. Moreover, they are essential building blocks in organic synthesis, particularly for the preparation of important hybrid molecules. The series of hybrid compounds containing indoles and imidazolidin-2-one moiety with direct C–C bond were synthesized using an amidoalkylation one-pot reaction. All compounds were investigated as a growth regulator for germination, growth and development of wheat seeds (Triticum aestivum L). Their effect on drought r

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42

Braña, Miguel F., Mercedes Garrido, María L. López Rodriguez, Pilar Miguel, M. José Morcillo та A. Riaño. "Synthesis of new derivatives of β-carboline-hydantoin". Journal of Heterocyclic Chemistry 27, № 3 (1990): 703–6. http://dx.doi.org/10.1002/jhet.5570270342.

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43

Aqeel, Abdel Wahab, Mahmoud A. Al-Sha'er, Rami Ayoub, Qais Jarrar, and Mahmoud A. Alelaimat. "Novel hydantoin derivatives: Synthesis and biological activity evaluation." Results in Chemistry 6 (December 2023): 101118. http://dx.doi.org/10.1016/j.rechem.2023.101118.

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44

Aganyants, Hovsep, Pierre Weigel, Yeranuhi Hovhannisyan, et al. "Rational Engineering of the Substrate Specificity of a Thermostable D-Hydantoinase (Dihydropyrimidinase)." High-Throughput 9, no. 1 (2020): 5. http://dx.doi.org/10.3390/ht9010005.

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D-hydantoinases catalyze an enantioselective opening of 5- and 6-membered cyclic structures and therefore can be used for the production of optically pure precursors for biomedical applications. The thermostable D-hydantoinase from Geobacillus stearothermophilus ATCC 31783 is a manganese-dependent enzyme and exhibits low activity towards bulky hydantoin derivatives. Homology modeling with a known 3D structure (PDB code: 1K1D) allowed us to identify the amino acids to be mutated at the substrate binding site and in its immediate vicinity to modulate the substrate specificity. Both single and do

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45

KRISHNA, C. JOSHI, N. PATHAK VIJAY, and K. GOYAL MAHENDRA. "Mass and 13C Nmr Spectral Studies of some 1,5-Di- and 1 ,3,5-Trisubstituted Fluorine-containing Hydantoins." Journal of Indian Chemical Society Vol. 66, Nov 1989 (1989): 806–9. https://doi.org/10.5281/zenodo.6105977.

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Department of Chemistry, University of Rajasthan, Jaipur-302 004 <em>Manuscript received 10 November 1988, accepted 26 June 1989</em> The mass spectral decomposition modes of various hydantoin derivatives containing C-5 fluoroaryl, N-aryl, N-3 dialkylaminomethyl, N-3 chloroacetyl and N-3 dialkylaminoacetyl substituents have been investigated. <sup>13</sup>C nmr spectral studies of some of the representative compounds have also been discussed.

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46

Jiang, Lu, and Bin Zeng. "Derivatives of Hydantoin: Synthesis and Antiproliferative Activity on HepG2 Cancer Cell Line." Advanced Materials Research 893 (February 2014): 512–15. http://dx.doi.org/10.4028/www.scientific.net/amr.893.512.

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Based on the study of rhodanine derivative WL-276,some novel compounds were synthesized,and their anti-tumor effects were screened by MTT method. Hydantoin is rhodanine of electronic derivative. Compounds of 3a-3d were obtained by Aldol reaction, whose structures were confirmed by 1H-NMR. Furthermore, preliminary pharmacological results suggested that compounds 2a had strong inhibitory effects on the proliferation of HepG2 tumor cells.

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SASAKI, Haruko. "Gold（I）Complexes of Hydantoin Derivatives and Their Properties." Journal of The Surface Finishing Society of Japan 71, no. 12 (2020): 828–32. http://dx.doi.org/10.4139/sfj.71.828.

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Szymańska, Ewa, and Katarzyna Kieć-Kononowicz. "Antimycobacterial activity of 5-arylidene aromatic derivatives of hydantoin." Il Farmaco 57, no. 5 (2002): 355–62. http://dx.doi.org/10.1016/s0014-827x(01)01194-6.

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Bellucci, Maria Cristina, Massimo Frigerio, Tommaso Marcelli, and Alessandro Volonterio. "ChemInform Abstract: Multicomponent Synthesis of N-Carbamoyl Hydantoin Derivatives." ChemInform 44, no. 29 (2013): no. http://dx.doi.org/10.1002/chin.201329131.

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50

Dios, Alfonso de, Maria Luz de la Puente, Alfonso Rivera-Sagredo, and Juan Felix Espinosa. "Structural and conformational studies of 5-(1H-pyrrol-2-ylmethylene)-substituted imidazolidine-2,4-diones and thiazolidine-2,4-diones." Canadian Journal of Chemistry 80, no. 10 (2002): 1302–7. http://dx.doi.org/10.1139/v02-175.

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Some imidazolidine-2,4-dione (hydantoin) and thiazolidine-2,4-dione (TZD) derivatives with a 1H-pyrrol-2-ylmethylene substituent at the 5-position (18) have been synthesized via an aldol condensation reaction. A mixture of Z- and E- stereoisomers was obtained, as confirmed by HPLC and NMR studies. Assignment of the stereochemistry was achieved through chemical shift knowledge, NOE, and 3JH,C data. The conformation of the molecules depends on the configuration at the double bond. While the (NH,C cis) form is the most stable conformer for the E-isomer, the (NH,C trans) form is the preferred con

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