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Journal articles on the topic 'Hydrazine – Synthèse'

Author: Grafiati

Published: 4 June 2021

Last updated: 17 February 2022

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1

Lerner, Hans-Wolfram, Nils Wiberg, Michael Bolte, H. Nöth, and J. Knizek. "Supersilyliertes Ammoniak und supersilyliertes Hydrazin: Synthese, Struktur und Eigenschaften / Supersilyl Ammonia and Supersilyl Hydrazine: Synthesis, Structure and Properties." Zeitschrift für Naturforschung B 57, no. 2 (February 1, 2002): 177–82. http://dx.doi.org/10.1515/znb-2002-0208.

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An excellent supersilylation agent, supersilyl triflate, tBu3SiO3SCF3, is easily obtained from tBu3SiH and CF3SO3H. Supersilyl triflate, tBu3SiO3SCF3, reacts with lithium amide or lithium hydrazide to form the supersilyl amine, tBu3SiNH2, or the supersilyl hydrazines, tBu3SiNHNH2 and tBu3SiNH-HNSitBu3, respectively. The structures of supersilyl triflate, tBu3SiO3SCF3, and bissupersilyl hydrazine, tBu3SiNH-HNSitBu3, have been determined by X-ray structure analysis.

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2

Vo, Thao T., and Jean'ne M. Shreeve. "1,1-Diamino-2,2-dinitroethene (FOX-7) and 1-amino-1-hydrazino-2,2-dinitroethene (HFOX) as amphotères: bases with strong acids." Journal of Materials Chemistry A 3, no. 16 (2015): 8756–63. http://dx.doi.org/10.1039/c4ta07098d.

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The exciting discovery of the first cations based on 1,1-diamino-2,2-dinitroethene (FOX-7) and its hydrazine derivative, 1-amino-1-hydrazino-2,2-dinitroethene (HFOX), along with their syntheses and full characterization is described.

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3

Kazakova, Oxana B., Natalya I. Medvedeva, Irina E. Smirnova, Tatyana V. Lopatina, and Alexander V. Veselovsky. "The Introduction of Hydrazone, Hydrazide, or Azepane Moieties to the Triterpenoid Core Enhances an Activity Against M. tuberculosis." Medicinal Chemistry 17, no. 2 (December 30, 2020): 134–45. http://dx.doi.org/10.2174/1573406416666200115161700.

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Background: Triterpenoids exhibit a wide spectrum of antimicrobial activity. Objective: The objective of this study was to synthesize a series of nitrogen derivatives based on lupane, oleanane, and ursane triterpenoids with high antitubercular activity. Methods: Isonicotinoylhydrazones were prepared via the reaction of 3-oxotriterpenic acids or betulonic aldehyde with isoniazid (INH) in yields of 54-72%. N-Acylation of betulonic or azepanobetulinic acids led to lupane C28 hydrazides and dihydrazides. The derivatives were evaluated for their in vitro antimycobacterial activities against Mycobacterium tuberculosis (MTB) H37RV and single-drug resistance (SDR)-TB in the National Institute of Allergy and Infectious Diseases, USA. Molecular docking was performed to evaluate the possible binding modes of investigated compounds in the active site of Diterpene synthase (Rv3378c). Results: The obtained compounds are represented by C3 or C28 conjugates with hydrazine hydrate or INH. Some compounds demonstrated from high minimum inhibitory concentration (MIC ≤ 10 μg/mL) to excellent (MICs from 0.19 to 1.25 μg/mL) activity against MTB H37RV. Two lupane conjugates with INH were the leading compounds against MTB H37RV and some SDR-strains with MICs ranged from 0.19 to 1.70 μg/mL. Molecular docking of active compounds to diterpene synthase showed that these moieties accommodate the active site of the enzyme. Conclusions: It was revealed that the conjugation of lupanes with INH at C3 is more effective than at C28 and the lupane skeleton is preferable among oleanane and ursane types. The replacement of native hexacarbocyclic A ring to seven-member azepane ring is favorably for inhibition of both MTB H37RV and SDR-strains. These data could possibly mean that the antitubercular activity against INH-resistant strains (INH-R) came from both triterpenoid and isoniazid parts of the hybrid molecules. Azepanobetulin showed the highest activity against both INH-R strains in comparison with other triterpenoids and INH. Thus, the introduction of hydrazone, hydrazide (dihydrazide), or azepane moieties into the triterpenoid core is a promising way for the development of new anti-tubercular agents.

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4

Salim, Saema, and Qamar Ali. "Design, Synthesis and Characterization of 2,4-Dimethylphenyl Hydrazine based Chemosensors." Scientific Inquiry and Review 4, no. 1 (March 2020): 46–58. http://dx.doi.org/10.32350/sir.41.04.

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Hydrazones are a unique division of compounds found in various syntheses. They have an important role in synthetic chemistrydue to their different biological properties, such as antifungal, anticonvulsant, antibacterial, antimalarial, anti-inflammatory and anti-TB properties. This paper reports the syntheses of a series of 3 hydrazones based on the condensation of 2,4-dimethylphenyl hydrazine HCl with different aromatic carbonyl compounds. The structures of the synthesized compounds were confirmed by EIMS. These compounds can act as ideal candidates in chemosensor chemistry.

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5

Enders, Dieter, and Christoph Thiebes. "Efficient stereoselective syntheses of piperidine, pyrrolidine, and indolizidine alkaloids." Pure and Applied Chemistry 73, no. 3 (January 1, 2001): 573–78. http://dx.doi.org/10.1351/pac200173030573.

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Recent advances in the diastereo- and enantioselective synthesis of piperidine, pyrrolidine, and indolizidine alkaloids, based on the highly stereoselective 1,2-addition to the CN double bond of chiral aldehyde-SAMP/RAMP hydrazones, are described. The enantioselective syntheses of the pyrrolidine alkaloids bgugaine and (2S,12¢R)-2-(12¢-aminotridecyl)-pyrrolidine, a defense alkaloid of the Mexican bean beetle are reported. Furthermore, the SAMP/RAMP-hydrazone method was applied to the syntheses of two 5,8-disubstituted indolizidine alkaloids that have been extracted from neotropical poison-dart frogs. The a-alkylation of aldehyde-SAMP/RAMP hydrazones has been used in the enantioselective synthesis of two epimers of stenusine, a 3-substituted piperidine alkaloid and spreading reagent of the beetle Stenus comma.

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6

Bode, Katrin, Uwe Klingebiel, Henning Witte-abel, Matthias Gluth, Mathias Noltemeyer, Regine Herbst-irmer, Martina Schäfer, and Walid Shomaly. "MONO-, BIS-, TRIS-, TETRAKIS(SILYL)HYDRAZINE, BIS-UND TRIS(HYDRAZINO)SILANE: SYNTHESE UND KRISTALLSTRUKTUREN." Phosphorus, Sulfur, and Silicon and the Related Elements 108, no. 1-4 (January 1, 1996): 121–40. http://dx.doi.org/10.1080/10426509608029646.

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7

Knieß, Astrid, Margit Gruner, and Roland Mayer. "Reaktionsverhalten von β-Oxo-carbonsäurederivaten der Anthracenreihe bei der Synthese von Pyrazolen / On the Reaction Behavior of ß-Oxo Carbonic Acid Derivatives of the Anthracene Series in Pyrazole Synthesis." Zeitschrift für Naturforschung B 54, no. 9 (September 1, 1999): 1133–37. http://dx.doi.org/10.1515/znb-1999-0908.

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ß-Oxo-1 and 9-anthracenepropionate (6 and 7) reacts with DMF-acetale to enaminones 10 and 11. The reaction of 2-(dimethylamino)methylen-substituted ß-oxo-1 -anthracenepropionate (10) with hydrazines yields 5-(l-anthracenyl)-pyrazol-4-carboxylates (13). In contrast, the cyclocondensation of 3-(9-anthracenyl)-2-(dimethylamino)methylen-3-oxo-propionate (11) with hydrazine hydrochlorides gives 4-(9-anthracenoyl)-5-hydroxy-pyrazoles (14). This is caused by the sterical hindrance of the carbonyl group of the anthracene derivatives in position 9; thus, the cyclocondensation proceeds via reaction of the ester group of the enaminone 11.

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8

Hassen, Zied, and Bechir Hajjem. "Action des Hydrazines Fluoroalkylées Sur Les α-Cetophosphonates: Synthèse des Hydrazones α-PhosphonyléesN-Fluoroalkylées." Phosphorus, Sulfur, and Silicon and the Related Elements 181, no. 5 (June 2006): 987–93. http://dx.doi.org/10.1080/10426500500272277.

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9

Klingebiel, Uwe, Karin Knipping, and Henning Witte-Abel. "Synthese thermisch stabiler N-Silylformaldehyd-hydrazone / Synthesis of Thermally Stable N-Silylformaldehyde-Hydrazones." Zeitschrift für Naturforschung B 52, no. 9 (September 1, 1997): 1049–50. http://dx.doi.org/10.1515/znb-1997-0905.

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10

Abass, Mohamed, Mostafa Ismail, Wafaa Abdel-Monem, and Aisha Mayas. "Substituted pyridopyrimidinones, Part IV: 2-chloro-4h-pyrido[1,2-a]pyrimidin-4-one as a synthone of some new heterotricycles." Journal of the Serbian Chemical Society 75, no. 1 (2010): 11–17. http://dx.doi.org/10.2298/jsc1001011a.

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2-Chloro-4H-pyrido[1,2-a]pyrimidin-4-one (1) was utilized as a synthone precursor to prepare novel heterotricyclic systems. 2-Azido and 2-hydrazino derivatives (2 and 3) were obtained by nucleophilic replacement evolving compound 1. The hydrazine derivative 3 was transformed into the azido derivative 2 by nitrosation. Treatment of compound 3 with [bis(methylthio)methylene] malononitrile afforded 2-pyrazolylpyridopyrimidine 4. When compound 1 was reacted with 5-amino-3-(methylthio)-1H-pyrazole-4-carbonitrile, the same compound 4 was obtained with no evidence for the production of (pyrazolylamino) pyridopyrimidine 5 or pyrazolodipyridopyrimidine 6. Poly-functionalized dipyridopyrimidine 8 was obtained by reaction of compound 1 with 2-[(methylthio)-( phenylamino)methylene]propanedinitrile. Cyanoguanidine was reacted with compound 1 to afford N-pyridopyrimidinylguanidine 9, which was subjected to cyclization reaction, in presence of piperidinium acetate, to give pyridopyrimidopyrimidine 10.

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11

Dietl, Andreas, Christian Kieser, and Thomas R. M. Barends. "A Peltier-cooled microscope stage for protein crystal post-crystallization treatment." Journal of Applied Crystallography 50, no. 4 (July 20, 2017): 1208–11. http://dx.doi.org/10.1107/s1600576717008755.

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Crystals of the multi-enzyme complex hydrazine synthase showed severe diffuse scattering and high mosaicity. Improved diffraction quality was achieved by soaking the crystals in highly concentrated betaine solutions at reduced temperatures. To enable this, a Peltier-cooled microscope stage was developed for the slow cooling of protein crystals immersed in cryoprotectants or other soaking solutions. Both the construction of the stage and its successful application to hydrazine synthase crystals are described.

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12

Mitkov, Javor, Alexandra Kasabova-Angelova, Magdalena Kondeva-Burdina, Virginia Tzankova, Diana Tzankova, Maya Georgieva, and Alexander Zlatkov. "Design, Synthesis and Evaluation of 8-Thiosubstituted 1,3,7- Trimethylxanthine Hydrazones with In-vitro Neuroprotective and MAO-B Inhibitory Activities." Medicinal Chemistry 16, no. 3 (April 17, 2020): 326–39. http://dx.doi.org/10.2174/1573406415666190531121927.

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Objective:The syntheses and biological activities of 8-thiosubstituted-1,3,7- trimethylxanthine derivatives bearing an aromatic hydrazide-hydrazone fragment in the side chain at C8 are described.Methods:The chemical structures of the synthesized compounds 6a-m were confirmed based on their MS, FTIR, 1H NMR and 13C NMR analyses.Results:The in vitro investigations of neuroprotective effects manifested on cellular (human neuroblastoma cell line SH-SY5Y) and sub-cellular (isolated rat brain synaptosomes) levels show that compounds 6g and 6i demonstrate statistically significant activity. The performed monoamine oxidase B (MAO-B) inhibition study in vitro show that compounds 6g and 6i possess a significant MAO-B inhibition activity close to L-deprenyl.Conclusion:These results suggest that such compounds may be utilized for the development of new candidate MAO-B inhibitors for the treatment of Parkinson’s disease.

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13

Flefel, Eman M., Walaa I. El-Sofany, Mahmoud El-Shahat, Arshi Naqvi, and Eman Assirey. "Synthesis, Molecular Docking and in Vitro Screening of Some Newly Synthesized Triazolopyridine, Pyridotriazine and Pyridine–Pyrazole Hybrid Derivatives." Molecules 23, no. 10 (October 6, 2018): 2548. http://dx.doi.org/10.3390/molecules23102548.

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A series of novel pyridine and fused pyridine derivatives have been prepared starting from 6-(3,4-dimethylphenyl)-2-hydrazinyl-4-(thiophen-2-yl)-pyridine-3-carbonitrile 1 which on treatment with appropriate formic acid, acetic acid/ acetic anhydride, benzoyl chloride and/or carbon disulfide afforded the corresponding triazolopyridine derivatives 2–5. Also, treatment of hydrazide 1 with diethyloxalate, chloroacetyl chloride, chloroacetic acid and/or 1,2-dichloroethane yielded the corresponding pyridotriazine derivatives 7–10. Further transformation of compound 1 with a different active methylene group, namely acetyl acetone, diethylmalonate, ethyl cyanoacetate, ethyl benzoylacetate and/or ethyl acetoacetate, produced the pyridine–pyrazole hybrid derivatives 11–15. These newly synthesized compounds (1–15) were subjected to in silico molecular docking screenings towards GlcN-6-P synthase as the target protein. The results revealed moderate to good binding energies of the ligands on the target protein. All the newly prepared products exhibited antimicrobial and antioxidant activity.

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14

Mäeorg, Uno, Leif Grehn, and Ulf Ragnarsson. "Ein prototypisches Reagens für die Synthese substituierter Hydrazine." Angewandte Chemie 108, no. 22 (November 18, 1996): 2802–3. http://dx.doi.org/10.1002/ange.19961082213.

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15

Wang, Zhongyong, Yuanyu Ma, Prathamesh B. Vartak, and Robert Y. Wang. "Precursors for PbTe, PbSe, SnTe, and SnSe synthesized using diphenyl dichalcogenides." Chemical Communications 54, no. 65 (2018): 9055–58. http://dx.doi.org/10.1039/c8cc03869d.

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16

Graubaum, Heinz, and Dieter Martin. "Zur Synthese des 5-Hydrazino-1,2,3,4-thiatriazols." Zeitschrift für Chemie 25, no. 4 (August 31, 2010): 136–37. http://dx.doi.org/10.1002/zfch.19850250405.

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17

Kamyabi, Mohammad Ali, Fatemeh Soleymani-Bonoti, Rahman Bikas, Hassan Hosseini-Monfared, Nematollah Arshadi, Milosz Siczek, and Tadeusz Lis. "Molecular oxygen reduction catalyzed by a highly oxidative resistant complex of cobalt–hydrazone at the liquid/liquid interface." Physical Chemistry Chemical Physics 17, no. 48 (2015): 32161–72. http://dx.doi.org/10.1039/c5cp04695e.

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Syntheses, structure and spectroscopic studies of a new cobalt complex with a hydrazine ligand. The first report on a highly oxidative resistant complex in the ORR electrocatalysis at the liquid–liquid interface.

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18

Jenke, Thomas, Helen Stoeckli-Evans, and Georg Süss-Fink. "Fixierung von hydrazinen und hydrazonen an dreikernigen rutheniumclustern: Synthese und molekülstruktur von (μ2-H)Ru3(CO)9(μ3-NHNH2)." Journal of Organometallic Chemistry 391, no. 3 (August 1990): 395–402. http://dx.doi.org/10.1016/0022-328x(90)85065-7.

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19

Dietl, Andreas, Christina Ferousi, Wouter J. Maalcke, Andreas Menzel, Simon de Vries, Jan T. Keltjens, Mike S. M. Jetten, Boran Kartal, and Thomas R. M. Barends. "The inner workings of the hydrazine synthase multiprotein complex." Nature 527, no. 7578 (October 19, 2015): 394–97. http://dx.doi.org/10.1038/nature15517.

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20

Ohme, Roland, and Alfred Zubek. "Synthesen des Hydrazins und seiner Alkylderivate." Zeitschrift für Chemie 8, no. 2 (September 2, 2010): 41–51. http://dx.doi.org/10.1002/zfch.19680080202.

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21

Kuhn, Norbert, Heike Kotowski, and Manfred Steimann. "Synthese und Kristallstruktur von 3.6-Di-tert-butylpyridazin / Synthesis and Crystal Structure of 3.6-Di-tert-butylpyridazine." Zeitschrift für Naturforschung B 54, no. 5 (May 1, 1999): 699–700. http://dx.doi.org/10.1515/znb-1999-0520.

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22

Bulka, E., and H. D. Dinse. "Synthese von 4-Aryl-thiazolyl-(2)-hydrazinen [1]." Zeitschrift für Chemie 5, no. 10 (September 2, 2010): 376–78. http://dx.doi.org/10.1002/zfch.19650051007.

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23

Kantlehner, Willi, Ioannis Tiritiris, Wolfgang Frey, and Ralf Kreß. "Orthoamide und Iminiumsalze, IC. Synthese und Reaktionen von N,N,N′,N′,N′′-Pentaalkyl-N′′-[2-(N,N,N′,N′,N′′-pentaalkylguanidinio)ethyl]-guanidiniumsalzen." Zeitschrift für Naturforschung B 75, no. 6-7 (August 27, 2020): 685–95. http://dx.doi.org/10.1515/znb-2019-0230.

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AbstractBis[bis(dibutylamino)methylen]hydrazine 8 is prepared from N,N,N′,N′-tetrabutylchloroformamidinium chloride (4c) and hydrazine. Bromine transforms 8 to the heterocyclic guanidinium salt 15a which is isolated as tetraphenylborate. From N,N,N′,N′-tetraalkylchloroformamidiniumchlorides and ethylendiamine the diguanidines are prepared which are alkylated to give diguanidinium salts, From these salts guanidinium salts can be prepared by anion metathesis with tetraphenylborate-, iodide-, hexafluorphosphate-, trifluoromethansulfonat-, bis(trifluormethansulfonyl)imide and tricyanmethanide as counteranions. The structure of the compounds 15 and 17b is confirmed by crystal structure analyses.

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24

Görth, Martin, Ute Schneider, Holger Ott, Carola Schulzke, Dietmar Stalke, and Uwe Klingebiel. "Synthese und Cyclisierung von Boryl- und Silylhydrazonen / Synthesis and Cyclisation of Boryl- and Silylhydrazones." Zeitschrift für Naturforschung B 65, no. 5 (May 1, 2010): 587–602. http://dx.doi.org/10.1515/znb-2010-0508.

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Reactions of the lithium salts of the tert-butylmethylhydrazones Me3C(Me)C=N-NLiR, (R = H, Me, CMe3) with fluorosilanes and -boranes in a molar ratio 1 : 1 gave the silyl- (1 - 3, 5, 6) and borylhydrazones (4, 8) Me3 C(Me)C=N-N(R)Rʹ; 1: R = H, Rʹ = SiFMe2 ; 2: R = H, Rʹ = SiMe2CMe3; 3: R = H, Rʹ = SiF(CMe3 )2; 4: R = H, Rʹ = BFN(SiMe3)2; 5: R = Me3 C, Rʹ = SiF2CMe3; 6: R = Me3C, Rʹ = F2SiC(SiMe3)3; 8: R = Me3C, Rʹ = BFN(SiMe3)2. The lithiated hydrazone Me2C=N-NH(Me) reacted with F3SiC(SiMe3)3 to give the silylhydrazone Me2C=N- NHSiF2C(SiMe3)3, 7. Because of the fluoro functionality of 1 and 4, the bis-hydrazonylsilane 9 and the bis- and tris-hydrazonylboranes 10 and 11 could be synthesised, (Me3C(Me)C=N-NH)2R; 9: R = SiMe2 , 10: R = BN(SiMe3)2; 11: (Me3C(Me)C=N-NH)3B. Starting from 2 and its lithium salt, secondary substitutions are possible. Bis(silyl)- and silyl(boryl)hydrazones are formed (12 - 15); Me3C(Me)C=N(R) (SiMe2CMe3) 12: R = SiFMe2; 13: R = SiF(CMe3)2; 14: R = SiF2CMe3; 15: R = BFN(SiMe3 )2. Ring closure occurs in the reaction of dilithiated Me2C=N- NHCMe3 with F2Si(CHMe2)2. The 1,2-diaza-3-sila-5-cyclopentene 16 is isolated. The fluorofunctional silyl-hydrazones 7, 12, and 13 cyclise in reactions with t-BuLi to give 1,2-diaza-3-sila-5- cyclopentenes 17 - 20; RN(N=CRʹ-CH2)Rʺ; 17: R =Me,Rʹ = Me3C, Rʺ = SiFC(SiMe3)3; 18: R = Me3C, Rʹ = SiMe2CMe3, Rʺ = SiMe2; 19: R =Me3C, Rʹ = SiMe2CMe3, Rʺ = Si(CMe3)2. A 1,2- diaza-3-bora-5-cyclopentene 20 is the result of the reaction of 8 with t-BuLi: Me3CN(N=CCMe3- CH2)BN(SiMe3)2. The H-acidic methylene group of the five-membered ring in 20 can be lithiated with n-BuLi and substituted with fluorosilanes. Starting from 16 and 20, the silyl-substituted rings Me3CN(N=CMe-CHR)Si(CHMe2)2 21 - 23 and 25 are obtained; 21: R = SiMe3; 22: R = SiF2C(SiMe3)3; 23: R = SiF3; 25: Me3CN[N=CC(Me)3CHSiMe3]BN(SiMe3)2. Using SiF4 as fluorosilane, the main product is the difluorosilane containing two rings; F2Si[CHC(Me)=N-NCMe3- Si(CHMe2)2]2. The methine group in 4-position of the silyl-substituted rings is also acidic and reacts with n-BuLi to give lithium salts which react with aminodifluoroboranes giving the ring compounds Me3CN[N=C(CMe3)C(SiMe2R)(FBNRʹ SiMe3)]SiMe2 26 - 28; 26: R = Me, Rʹ = CMe3; 27: R = F, Rʹ = CMe3 ; 28: R = F, Rʹ = SiMe3. In contrast to the substitution reactions of fluorosilanes with lithiated rings, an unusual oxidation reaction occurs starting from lithiated Me3CN(N=C(CMe3)CH2)Si(CHMe2)2 and ClSiMe2CMe3 to give 29, in which a C-C bond in 4- position links two five-membered rings. The disilane (Me3CSiMe2)2 is formed as a by-product of this reaction. The combination of the N-SiF2CMe3-substituted hydrazones 5 and 14 with t-BuLi in a molar ratio 1 : 2 leads to the colourless, crystalline tricyclic products 30 and 31 which are dimeric 1,2-diaza-3-sila-3,5-cyclopentadienes. The molecular structures of 3, 6, 11, 30, and 31 are reported.

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25

Graubaum, H., G. Lutze, and M. Ramm. "SYNTHESE UND REAKTIONEN VON HYDRAZINO-1,6,6aλ4-TRITHIA-3,4-DIAZAPENTALENEN." Phosphorus, Sulfur, and Silicon and the Related Elements 84, no. 1-4 (November 1, 1993): 83–93. http://dx.doi.org/10.1080/10426509308034318.

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26

Zhang, Bing Cong, Hong Ying Yu, and Dong Bai Sun. "Shape-Controlled Synthesis and Formation Mechanism of Cobalt Nanopowders by a PVP-Assisted Method." Materials Science Forum 654-656 (June 2010): 1186–89. http://dx.doi.org/10.4028/www.scientific.net/msf.654-656.1186.

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Three different kinds of morphologies including spherical, chainlike and wirelike cobalt nanopowders, have been synthesized by chemical reduction of coblat chloride solution with hydrazine hydrate in basic solution. The products were characterized by X-ray diffraction (XRD) and field emission scanning electron microscopy (FESEM). It was revealed that the morphologies of the nanopowders depend on the concentration of Co2+ and the way of adding reducing agent (hydrazine hydrate). These two features affected the nucleation sites and the number of nucleuses. When the concentration of Co2+ was low, nucleuses formed in the soft template, while the reducing of the reducing agent added drop wise, a little number of nucleuses was formed. Based on that, a mechanism of formation, as a basis of gram-scale syntheses, was proposed.

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27

Katrusiak, Anna, Małgorzata Ratajczak-Sitarz, Urszula Skierska, and Wiktoria Zinczenko. "Nucleophilic Substitution and Lipophilicity - Structure Relations in Methylazolopyridazines." Collection of Czechoslovak Chemical Communications 70, no. 9 (2005): 1372–86. http://dx.doi.org/10.1135/cccc20051372.

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Syntheses of methyl[1,2,4]triazolo- or methyltetrazolopyridazine isomers, their separation and nucleophilic substitution with morpholine, dimethylamine and hydrazine have been described. The lipophilicity of the azolopyridazines has been measured and related to the number and sites of the methyl substituents. The structures of new methylated azolopyridazines have been characterized by 1H NMR, MS spectra, and X-ray diffraction.

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28

Geffken, Detlef, Hans von Zydowitz, and Alf Ploetz. "Synthese und Ringumwandlungen von 1,2,5-Oxadiazinan-3,6-dionen / Synthesis and Ring Transformations of 1,2,5-Oxadiazinan-3,6-diones." Zeitschrift für Naturforschung B 60, no. 9 (September 1, 2005): 967–72. http://dx.doi.org/10.1515/znb-2005-0910.

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1,2,5-Oxadiazinan-3,6-diones (8), easily available by cyclic carbonylation of α-amino-carbohydroxamic acids 7 with 1,1’-carbonyldiimidazole, are reacted with hydrazine to give 3- aminohydantoins (10). Depending on the substituents R1/R’ 8 was found to undergo an imidazole catalyzed oxidoreduction to 4-imidazolidinones (11) or α-iminophenylacetamides (12).

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29

Barends, Thomas R. M. "How bacteria make rocket fuel: structure and mechanism of hydrazine synthase." Acta Crystallographica Section A Foundations and Advances 72, a1 (August 28, 2016): s249. http://dx.doi.org/10.1107/s2053273316096224.

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30

Neunhoeffer, Hans, Ute Karafiat, Gernot Köhler, and Birgit Sowa. "Hydrazidine, V. Synthese und Reaktionen aromatischer und aliphatischer Hydrazidine und derenN1-substituierter Derivate." Liebigs Annalen der Chemie 1992, no. 2 (February 12, 1992): 115–26. http://dx.doi.org/10.1002/jlac.199219920123.

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31

Kohlbaua, Hans-Jürgen, Jochen Tschakert, Raed A. Al-Qawasmeh, Tanveer Ahmad Nizamì, Abdul Malik, and Wolfgang Voelter. "Festphasensynthese von Muramyldipeptiden an isomeren Trialkoxybenzylamin-Harzen / Solid Phase Synthesis of Muramyl Dipeptides on Isomeric Trialkoxybenzylamine Resins." Zeitschrift für Naturforschung B 53, no. 7 (July 1, 1998): 753–64. http://dx.doi.org/10.1515/znb-1998-0716.

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Abstract New isomeric trialkoxybenzylamine resins are developed coupling phthalimidomethyl-3,5-dimethoxyphenols to the Merrifield resin, followed by subsequent treatment with hydrazine. The generated benzylamine function allows DCC coupling w ith the carboxyl function of amino acids and peptides which are removed as amides after treatment with trifluoroacetic acid. These new trialkoxybenzylamine resins allow expeditious syntheses of peptide amides and glycopeptide amides as is demonstrated for muramyl peptides and analogues.

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32

Fischer, Helmut, and Gerhard Roth. "Hydrazinocarben-Metallkomplexe—synthese aus allenylidenkomplexen und hydrazinen, umlagerung und cyclisierung." Journal of Organometallic Chemistry 490, no. 1-2 (March 1995): 229–37. http://dx.doi.org/10.1016/0022-328x(94)05187-g.

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33

Mótyán, Gergő, Barnabás Molnár, János Wölfling, and Éva Frank. "Microwave-Assisted Stereoselective Heterocyclization to Novel Ring d-fused Arylpyrazolines in the Estrone Series." Molecules 24, no. 3 (February 4, 2019): 569. http://dx.doi.org/10.3390/molecules24030569.

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Microwave-assisted syntheses of novel ring d-condensed 2-pyrazolines in the estrone series were efficiently carried out from steroidal ,-enones and hydrazine derivatives. The ring-closure reaction of 16-benzylidene estrone 3-methyl ether with hydrazine in acetic acid resulted in a 2:1 diastereomeric mixture of two 16,17-cis fused pyrazolines, which is contrary to the former literature data for both stereoselectivity and product structure. However, the cyclization reactions of a mestranol-derived unsaturated ketone with different arylhydrazines in acidic ethanol furnished the heterocyclic products in good to excellent yields independently of the substituents present on the aromatic ring of the reagents applied. The MW conditions also permitted the ring-closure reaction with p-nitrophenylhydrazine which is unfavorable under conventional heating. Moreover, the transformations led to the heterocyclic compounds stereoselectively with a 16,17-cis ring junction without being susceptible to spontaneous and promoted oxidation to pyrazoles.

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34

Gattow, G., and S. Lotz. "�ber Chalkogenolate. 164. Umsetzungen von Hydrazin mit Kohlenstoffdisulfid. 3. Synthese und Charakterisierung von Trinatrium-1,2-hydrazin-bis(dithiocarboxylat)." Zeitschrift f�r anorganische und allgemeine Chemie 531, no. 12 (December 1985): 97–100. http://dx.doi.org/10.1002/zaac.19855311214.

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35

Hassen, Zied, Azaı̈ez Ben Akacha, and Béchir Hajjem. "Action des hydrazines fluoroalkylées sur les phosphoallènes: synthèse d’hydrazones N-fluoroalkylées β-phosphonatées." Journal of Fluorine Chemistry 121, no. 2 (June 2003): 177–83. http://dx.doi.org/10.1016/s0022-1139(03)00013-7.

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36

Brecknell, DJ, RM Carman, and RC Schumann. "Kinetic v. Thermodynamic Effects During a Wolff-Kishner Reduction." Australian Journal of Chemistry 42, no. 4 (1989): 527. http://dx.doi.org/10.1071/ch9890527.

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A Wolff-Kishner reduction is discussed which leads to kinetic products through reduction of hydrazones derived from thermodynamically less-stable ketones of an equilibrium mixture. The syntheses and conformational analyses of a range of 9-substituted 2,3,6,7-tetramethyldecahydroanthracenes are discussed.

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37

Akacha, Azaiez Ben, Salim Barkallah, and Belgacem Baccar. "REACTION DES O, O-DIETHYL OXO-1 ALKANEPHOSPHONATES AVEC LES DERIVES DE L'HYDRAZINE: UNE VOIE DE SYNTHESE DES HYDRAZONES α-PHOSPHONATEES ET DES HYDRAZIDES." Phosphorus, Sulfur, and Silicon and the Related Elements 69, no. 1-2 (June 1992): 163–66. http://dx.doi.org/10.1080/10426509208036865.

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38

Zhou, Zhichao, Jing Chen, Han Meng, Volodymyr Dvornyk, and Ji-Dong Gu. "New PCR primers targeting hydrazine synthase and cytochrome c biogenesis proteins in anammox bacteria." Applied Microbiology and Biotechnology 101, no. 3 (December 28, 2016): 1267–87. http://dx.doi.org/10.1007/s00253-016-8013-7.

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39

Haake, Manfred, and Winfried Jürgler. "Synthese neuer 1λ6- und 1λ4,2,4,6-Thiatriazine aus S,S-Diorganosulfodiimiden / Synthesis of Novel 1λ6- and 1λ4,2,4,6-Thiatriazines from S,S-Diorganosulfodiimides." Zeitschrift für Naturforschung B 43, no. 6 (June 1, 1988): 763–68. http://dx.doi.org/10.1515/znb-1988-0621.

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From S,S-diorganosulfodiimides 1a-e with diphenylcyanimidocarbonate (2) via condensation products 3a-e and 6a-d novel heterocycles were obtained. In DMF 3a-c react with aliphatic amines to form 1λ4,2,4,6-thiatriazines 4a-e and 5a, b. With HCl 6a-d can be cyclized to give 1λ6,2,4,6-thiatriazine hydrochlorides 8a-d. These are thermally converted into 1λ4,2,4,6-thiatriazines 4a, f, g. Condensation of 6a with orthoesters and paraformaldehyde affords 1λ6,2,4,6- thiatriazines 9a, b and 10a, whereas 3a, e undergoes ring closure with methyl hydrazine to 1,2,4- triazoles 11a, e.

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40

Kalpanadevi, K., C. R. Sinduja, and R. Manimekalai. "Characterisation of Zinc Oxide and Cadmium Oxide Nanostructures Obtained from the Low Temperature Thermal Decomposition of Inorganic Precursors." ISRN Inorganic Chemistry 2013 (September 4, 2013): 1–5. http://dx.doi.org/10.1155/2013/823040.

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Low temperature syntheses of zinc oxide and cadmium oxide nanoparticles are reported in this paper. The inorganic precursor complexes were prepared and characterised by hydrazine and metal analyses, infrared spectral analysis, and thermal analysis. Using appropriate annealing conditions, zinc oxide and cadmium oxide nanoparticles of average particle sizes around 13 nm and 30 nm were synthesised from the precursors by a simple thermal decomposition route. The synthesised nanoparticles were characterised for their size and structure using X-Ray diffraction (XRD), high resolution transmission electron microscopy (HRTEM), selected area electron diffraction (SAED), and scanning electron microscopy (SEM) techniques.

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41

Geffken, Detlef, and Alf Ploetz. "Synthese von 6-Thioxo-1,2,5-oxadiazinan-3-onen und Umwandlung in 3-Amino-2-thiohydantoine und 3-Hydroxy-2-thiohydantoine / Synthesis of 6-Thioxo-1,2,5-oxadiazinan-3-ones and Transformation into 3-Amino-2-thiohydantoins and 3-Hydroxy-2-thiohydantoins." Zeitschrift für Naturforschung B 61, no. 1 (January 1, 2006): 83–86. http://dx.doi.org/10.1515/znb-2006-0117.

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6-Thioxo-1,2,5-oxadiazinan-3-ones 5, easily available by cyclic thiocarbonylation of Nα ,Ndisubstituted α-aminocarbohydroxamic acids 4 with 1,1′-thiocarbonyldiimidazole, are transformed by hydrazine or hydroxylamine into 3-amino-2-thiohydantoins 6 and 3-hydroxy-2-thiohydantoins 7.

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42

Enders, Dieter, and Ulrich Reinhold. "Diastereo- und enantioselektive Synthese von 1,2-Aminoalkoholen aus Glycolaldehyd-Hydrazonen – asymmetrische Synthese von (R,R)-Statin." Angewandte Chemie 107, no. 11 (June 2, 1995): 1332–34. http://dx.doi.org/10.1002/ange.19951071116.

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43

Khatun, Rabeya, AS Mansarul Islam, and MA Hai. "Synthesis of Schiff Base having a Heterocyclic Moiety along with its Cyclized Derivatives and Study of their Antifungal Activities." Journal of the Bangladesh Chemical Society 25, no. 1 (September 2, 2012): 7–14. http://dx.doi.org/10.3329/jbcs.v25i1.11765.

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Syntheses of Schiffs base1 1-[(2, 4-difluorophenyl)-2-(1H-1, 2, 4-triazol-1-yl)] ethanone thiosemicarbazone (1A) prepared by condensation of 1-(2,4- difluorophenyl)-2-[1(H)-1,2,4-triazol-1-yl] ethanone with thiosemicarbazide, followed by cyclization2 to 2-(2,4-difluorophenyl)-2-[(1H)-1,2,4-triazol-1- ylmethyl)]-3-acetyl-5-acetylamino- thiadiazoline ( 2A), using acetic anhydride, and finally hydrolysis3 of (2A) to form 2-(2,4-difluorophenyl)-2-[(1H)-1,2,4-triazol-1- ylmethyl)]-3-acetyl-5-amino-thiadiazoline (3A), using hydrazine hydrate, all compounds having anti-fungal activities, are reported. DOI: http://dx.doi.org/10.3329/jbcs.v25i1.11765 Journal of Bangladesh Chemical Society, Vol. 25(1), 7-14, 2012

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44

Noguiera, Thais C. M., Alessandra C. Pinheiro, James L. Wardell, Marcus V. N. de Souza, Jordan P. Abberley, and William T. A. Harrison. "Different hydrogen-bonded chains in the crystal structures of three alkylN-[(E)-1-(2-benzylidene-1-methylhydrazinyl)-3-hydroxy-1-oxopropan-2-yl]carbamates." Acta Crystallographica Section E Crystallographic Communications 71, no. 7 (June 6, 2015): 752–56. http://dx.doi.org/10.1107/s2056989015010440.

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The crystal structures of three methylated hydrazine carbamate derivatives prepared by multi-step syntheses from L-serine are presented, namely benzylN-{(E)-1-[2-(4-cyanobenzylidene)-1-methylhydrazinyl]-3-hydroxy-1-oxopropan-2-yl}carbamate, C20H20N4O4,tert-butylN-{(E)-1-[2-(4-cyanobenzylidene)-1-methylhydrazinyl]-3-hydroxy-1-oxopropan-2-yl}carbamate, C17H22N4O4, andtert-butylN-[(E)-1-(2-benzylidene-1-methylhydrazinyl)-3-hydroxy-1-oxopropan-2-yl]carbamate, C16H23N3O4. One of them shows that an unexpected racemization has occurred during the mild-condition methylation reaction. In each crystal structure, the molecules are linked into chains by O—H...O hydrogen bonds, but with significant differences between them.

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45

Drost, Christian, Carsten Jäger, Uwe Klingebiel, Christina Freire-Erdbrügger, Regine Herbst-Irmer, and Martina Schäfer. "Lithium- [N-di-tert-butylfluorsilyl-N′,Ν′-dimethyl-hydrazid] -Synthese, Kristallstruktur und Reaktivität / Lithium (N-di-tert-butylfluorosilyl-N′,N′-dimethyl)hydrazide -Synthesis, Crystal Structure and Reactivity." Zeitschrift für Naturforschung B 50, no. 1 (January 1, 1995): 76–80. http://dx.doi.org/10.1515/znb-1995-0115.

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Di-tert-butyldifluorosilane reacts with N-lithium-N′,N′-dimethylhydrazine in a molar ratio 1:1 to yield the N-di-tert-butylfluorosilyl-N′,N′-dimethylhydrazine 1. The lithium derivative of 1 (2) forms a dimer with the nitrogen atoms coordinated “side-on” to the lithium atoms. The silylation with Me3SiCl gives product 3. Heating 2 in a vacuum leads to the cyclodisilazane derivative 4. A bis(hydrazino)fluoroborane (5) is obtained in the reaction of 2 with trifluoroborane-etherate.

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46

Jin, Zhigang, Gregory A. Bohach, Joseph Shiloach, Scott E. Norris, Darón I. Freedberg, Claudia Deobald, Bruce Coxon, John B. Robbins, and Rachel Schneerson. "Conjugates of Group A and W135 Capsular Polysaccharides of Neisseria meningitidis Bound to Recombinant Staphylococcus aureus Enterotoxin C1: Preparation, Physicochemical Characterization, and Immunological Properties in Mice." Infection and Immunity 73, no. 12 (December 2005): 7887–93. http://dx.doi.org/10.1128/iai.73.12.7887-7893.2005.

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ABSTRACT Neisseria meningitidis groups A (GAM) and W135 capsular polysaccharides (CPs) were bound to recombinant Staphylococcus aureus enterotoxin C1 (rSEC). The CPs were activated with 1-cyano-4-dimethylaminopyridinium tetrafluoroborate and then bound to adipic acid dihydrazide derivatives of rSEC. Syntheses were conducted with native GAM CP (GAMP), W135 CP (W135P), and ultrasonicated or hydrazine-treated W135P at various concentrations of reactants, pHs, and ionic strengths. The conjugates were characterized by compositional and serologic analyses, high-performance size-exclusion chromatography with multi-angle laser light scattering detection, and immunogenicity in 5- to 6-week-old mice. Conjugates injected subcutaneously in phosphate-buffered saline elicited immunoglobulin G (IgG) responses against their respective CPs and rSEC, whereas GAMP and W135P alone did not induce detectable CP antibodies. The O-acetyl content of W135P was low, and its removal had no adverse effect upon the conjugate's immunogenicity. Reduction of the molecular size of W135P by treatment with hydrazine improved the immunogenicity of W135P-rSEC. IgG anti-CP elicited by the conjugates showed complement-dependent bactericidal activity against their respective organisms, and IgG anti-rSEC neutralized the T-cell proliferative activity of native SEC. A bivalent formulation of GAMP-rSEC and W135P-rSEC elicited IgG anti-CP at comparable levels to those induced by the conjugates administered separately.

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47

Kim, Jang, Nam, Lee, and Lee. "Inhibition of LPS-Induced PGE2 Production by Arylsulfonamide Derivatives via the Selective Inhibition of mPGES-1 Enzyme." Proceedings 22, no. 1 (August 7, 2019): 37. http://dx.doi.org/10.3390/proceedings2019022037.

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Microsomal prostaglandin E synthase-1 (mPGES-1) is responsible for the massive prostaglandin E2 (PGE2) formation during inflammation. Increasing evidence reveals mPGES-1 inhibitors as a safe alternative to nonsteroidal anti-inflammatory drugs. Recently, we reported that a novel series of phenylsulfonyl hydrazide derivatives could reduce LPS-induced PGE2 levels in RAW 264.7 macrophage cells via an inhibition of the mPGES-1 enzyme. However, a few of the phenylsulfonyl hydrazide derivatives showed poor metabolic stability in liver microsomes. In order to identify new mPGES-1 inhibitors with improved metabolic stability, therefore, a series of arylsulfonamide derivatives has been synthesized and biologically evaluated against PGE2 production and the mPGES-1 enzyme. Among them, MPO-0186 inhibits the production of PGE2 (IC50 = 0.20 μM) in A549 cells via inhibition of mPGES-1 (IC50 = 0.49 μM in a cell-free assay) together with high selectivity over both COX-1 and COX-2. A molecular docking study theoretically suggests that MPO-0186 could inhibit PGE2 production by blocking the PGH2 binding site of the mPGES-1 enzyme. Furthermore, MPO-0186 demonstrated good metabolic stability in human liver microsomes and no significant inhibition observed in clinically relevant CYP isoforms.

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48

Lees, Jarmon G., Anne M. Kong, Yi C. Chen, Priyadharshini Sivakumaran, Damián Hernández, Alice Pébay, Alexandra J. Harvey, David K. Gardner, and Shiang Y. Lim. "Mitochondrial Fusion by M1 Promotes Embryoid Body Cardiac Differentiation of Human Pluripotent Stem Cells." Stem Cells International 2019 (September 19, 2019): 1–12. http://dx.doi.org/10.1155/2019/6380135.

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Human induced pluripotent stem cells (iPSCs) can be differentiated in vitro into bona fide cardiomyocytes for disease modelling and personalized medicine. Mitochondrial morphology and metabolism change dramatically as iPSCs differentiate into mesodermal cardiac lineages. Inhibiting mitochondrial fission has been shown to promote cardiac differentiation of iPSCs. However, the effect of hydrazone M1, a small molecule that promotes mitochondrial fusion, on cardiac mesodermal commitment of human iPSCs is unknown. Here, we demonstrate that treatment with M1 promoted mitochondrial fusion in human iPSCs. Treatment of iPSCs with M1 during embryoid body formation significantly increased the percentage of beating embryoid bodies and expression of cardiac-specific genes. The pro-fusion and pro-cardiogenic effects of M1 were not associated with changes in expression of the α and β subunits of adenosine triphosphate (ATP) synthase. Our findings demonstrate for the first time that hydrazone M1 is capable of promoting cardiac differentiation of human iPSCs, highlighting the important role of mitochondrial dynamics in cardiac mesoderm lineage specification and cardiac development. M1 and other mitochondrial fusion promoters emerge as promising molecular targets to generate lineages of the heart from human iPSCs for patient-specific regenerative medicine.

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49

Alswah, Mohamed, Adel Ghiaty, Ahmed El-Morsy, and Kamal El-Gamal. "Synthesis and Biological Evaluation of Some [1,2,4]Triazolo[4,3-a]quinoxaline Derivatives as Novel Anticonvulsant Agents." ISRN Organic Chemistry 2013 (September 12, 2013): 1–7. http://dx.doi.org/10.1155/2013/587054.

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2-([1,2,4]Triazolo[4,3-a]quinoxalin-4-ylthio)acetic acid hydrazide (10) was used as a precursor for the syntheses of novel quinoxaline derivatives with potential anticonvulsant properties. The newly synthesized compounds have been characterized by IR, 1H NMR, and mass spectral data followed by elemental analysis. The anticonvulsant evaluation was carried out for eleven of the synthesized compounds using metrazol induced convulsions model and phenobarbitone sodium as a standard. Among this set of tested compounds, two of them (14, and 15b) showed the best anticonvulsant activities.

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50

Kumar, Manoj, Shashi Sharma, Hardeep Singh Tuli, and Rajshree Khare. "A Novel Synthesis, Characterization and Biological Studies of Ferrocenyl Substituted Pyrazoles." Asian Journal of Chemistry 31, no. 12 (November 16, 2019): 2729–32. http://dx.doi.org/10.14233/ajchem.2019.22161.

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It has been discovered that ferrocenyl substituted heterocyclic compounds have wide scope of restorative methodology. The combination of ferrocenyl substituted pyrazole is the new class in these compounds with upgraded natural activity. This work center around blend of ferrocenyl substituted pyrazoles through novel course. The combination of 1-phenyl-3-ferrocenyl-pyrazole was examined including addition-cyclocondensation like response conditions. The response continued through three phases using of expansion cyclo-buildup of acetyl ferrocene with phenyl hydrazine pursued by cyclizing reagent iodine with NaHCO3. In both syntheses, each time single product isolated having good yields (87 and 79 %). Ferrocenyl substituted pyrazoles were examined by spectroscopic techniques (1H NMR, IR, MS) and their biological properties have been screened.

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