Relevant bibliographies by topics / Hydrazino derivatives

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers

Academic literature on the topic 'Hydrazino derivatives'

Author: Grafiati
Published: 5 June 2025
Last updated: 1 August 2025

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Journal articles on the topic "Hydrazino derivatives"

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Ibrahim, Hassan K., Sayed H. El-Tamany, Reda F. El-Shaarawy, and Ibrahim M. El-Deen. "Synthesis and investigation of mass spectra of some novel benzimidazole derivatives." Macedonian Journal of Chemistry and Chemical Engineering 27, no. 1 (2008): 65. http://dx.doi.org/10.20450/mjcce.2008.248.

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2-Substituted benzimidazoles (3) and (4a-c) were prepared via condensation of ethyl 2-thionyl-pyruvate (1) and hydrazidoyl derivatives (2a-c) with o-phenylene diamine in acetic acid. Acetylation of compound (4a) with acetic anhydride yielded the corresponding N-acetyl derivative (5). Treatment of compound 4b with hydrazine hydrate gave the corresponding hydrazino derivative (6). Reaction of 2-[(2-thionyl)acetyl)] benzimidazole (3) with hydrazine hydrate gave the pyrazolyl derivative (7) and hydrazino derivative (8). Alkylation of compound 3 with alkyl halide gave the corresponding 2,3-disubsti
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2

Hossain, M. I., and M. M. H. Bhuiyan. "Synthesis and Antimicrobial Activities of Some New Thieno and Furopyrimidine Derivatives." Journal of Scientific Research 1, no. 2 (2009): 317–25. http://dx.doi.org/10.3329/jsr.v1i2.2299.

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Fused pyrimidines, 8,9-dimethyl[1,2,4]triazolo[4,3-c]thieno[3,2-e]pyrimidine 5, 3,8,9-trimethyl[1,2,4]triazolo[4,3-c]thieno[3,2-e]pyrimidine 6, 4-benzylidinehydrazono-5,6 dimethylthieno[2,3-d]pyrimidine 7, 4-[4/-hydroxybenzylidine]hydrazono-5,6-dimethylthi-eno[2,3-d]pyrimidine 8, 4-[4/-tolylidin]hydrazono-5,6-dimethylthieno[2,3-d]pyrimidine 9, 4-[4/-nitrobenzylidine]hydrazono-5-ethyl-6-methylthieno[2,3-d]pyrimidine 10 and 4-[4/-chlorobenzylidine]hydrazono-5-ethyl-6-methylthieno[2,3-d]pyrimidine 11 are prepared in good yield by an initial treatment of 2-amino-4,5-dimethylthiophene-3-carbonitril
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Edrees, Mastoura M. "Synthesis of 4-hydrazinopyrazolo[3,4-d]pyrimidines and their Reactions with Carbonyl Compounds." Journal of Chemical Research 37, no. 1 (2013): 6–10. http://dx.doi.org/10.3184/174751912x13543818811749.

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Synthesis of a new 4-hydrazinopyrazolo[3,4- d]pyrimidine was achieved via heating (4,6-dithioxo-1 H-pyrazolo[3,4- d] pyrimidin-3-yl)acetonitrile with hydrazine hydrate. Reactions of the latter product with thiophene-2-carbaldehyde and ethyl hydrazonoacetoacetate analogues afforded the corresponding hydrazone and pyrazole derivatives, respectively. Similarly, condensation of 2-[6-(benzylsulfanyl)-4-hydrazino-1 H-pyrazolo[3,4- d]pyrimidin-3-yl]acetonitrile with thiophene-2-carbaldehyde and ethyl hydrazonoacetoacetate analogues gave the respective hydrazone and pyrazolone derivatives. Alkylation
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Metwally, Mohamed Abbas, and M. A. Sofan. "Synthesis of Some New Pyrrolo Heterocycles of Pharmaceutical Interest from 1,4-Diphenylpyrrolidine-2,3,5-trione+." Zeitschrift für Naturforschung B 45, no. 3 (1990): 382–84. http://dx.doi.org/10.1515/znb-1990-0313.

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Continuing earlier studies designed to obtain derivatives of pharmacological interest, some novel compounds 2, 5, 6, 7 and 8 were prepared using 1,4-diphenylpyrrolidine-2,3,5-trione (1) and 1,2-phenylenediamines, o-aminophenol, 1,3-diphenylacetone and thiosemicarbazide, respectively. The hydrazino derivative (8) was obtained from 7 and hydrazine hydrate. Structural identification was obtained by 1H NMR, mass spectra and IR spectral data.
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Journal, Baghdad Science. "Synthesis of Some Heterocyclic Compounds Derived from 2-Mercapto Benzoxazole." Baghdad Science Journal 10, no. 3 (2013): 766–78. http://dx.doi.org/10.21123/bsj.10.3.766-778.

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New series of 2-mecapto benzoxazole derivatives (1-20) incorporated into fused to different nitrogen and suphur containing heterocyclic were prepared from 2-meracpto benzoxazole, when treated with hydrazine hydrate to afford 2-hydrazino benzoxazol (1). Compound (1) converted to a variety of pyridazinone andphthalazinone derivatives (2-4) by reaction with different carboxylic anhydride. Also, reaction of (1) with phenyl isothiocyanate and ethyl chloro acetate afforded 3-phenyl-1,3-thiazolidin-2,4-dione-2-(benzoxazole-2-yl-hydrazone) (6). Azomethines (7-10) were prepared through reaction of (1)
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Askar, Firyal W., Huda A. Hassan, and Nahida A. Jinzeel. "Synthesis of Some Heterocyclic Compounds Derived from 2-Mercapto Benzoxazole." Baghdad Science Journal 10, no. 3 (2013): 766–78. http://dx.doi.org/10.21123/bsj.2013.10.3.766-778.

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New series of 2-mecapto benzoxazole derivatives (1-20) incorporated into fused to different nitrogen and suphur containing heterocyclic were prepared from 2-meracpto benzoxazole, when treated with hydrazine hydrate to afford 2-hydrazino benzoxazol (1). Compound (1) converted to a variety of pyridazinone andphthalazinone derivatives (2-4) by reaction with different carboxylic anhydride. Also, reaction of (1) with phenyl isothiocyanate and ethyl chloro acetate afforded 3-phenyl-1,3-thiazolidin-2,4-dione-2-(benzoxazole-2-yl-hydrazone) (6). Azomethines (7-10) were prepared through reaction of (1)
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Alheety, Nuaman. "Synthesis, Characterization and Antimicrobial Activity Study of Some New Substituted Benzoxazole Derivatives." Baghdad Science Journal 16, no. 3 (2019): 616. http://dx.doi.org/10.21123/bsj.2019.16.3.616.

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This research included the preparation of 2-mercaptobenzoxazole (N1) by the reaction of ortho-aminophenol with carbon disulfide in an alcoholic potassium hydroxide solution. The 2-mercapto benzoxazole (N1) was then treated with hydrazine to obtain the 2-hydrazino benzoxazole (N2). A number of hydrazones (N3-N5) were prepared through the reaction of N2 with different benzaldehydes. The compound (N6) was also prepared whereby the ring closing of hydrazone (N3) using chloroacetylchloride, while the compound (N7) was prepared by treating 2-hydrazino benzoxazole with acetylacetone. When the compoun
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ABDUL, U. SIDDIQUI, H. SIDDIQUI A., and SUNDARA RAMAIAH T. "Synthesis of Steroidal and Terpenoidal Extranucleo Thiazolidinones." Journal of Indian Chemical Society Vol. 69, Feb 1992 (1992): 85–86. https://doi.org/10.5281/zenodo.5993007.

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Department of Chemistry, Nizam College, Osmania University, Hyderabad-500 001 <em>Manuscript received 26 December 1991, accepted 17 February 1992</em> 3-Oxo-5&beta;-cholan-24-oic-acid (la), 3-oxo-lanost-8,24-diene (2a) and 3-oxo-olean-12-ene (3a) on reaction with hydrazine hydrate in alcoholic solution gave the respective 3-hydrazones (lb, 2b and 3b). Subsequent reaction of these 3-hydrazones with ammonium thiocyanate in benzene solution afforded 3-thiosemicarbazone derivatives (lc, 2c and 3c) which undergo cyclisation with chloroacetic acid in the presence of anhydrous sodium acetate to yield
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Hassaneen, Hamdi M., Fatma M. Saleh, Tayseer A. Abdallah, et al. "Synthesis, Cytotoxicity, Antimicrobial and Docking Simulation of Novel Pyrazolo[3,4-d]pyrimidine and pyrazolo[4,3-e][1,2,4]triazolo[3,4-c] pyrimidine Derivatives." Mini-Reviews in Medicinal Chemistry 19, no. 8 (2019): 657–70. http://dx.doi.org/10.2174/1389557518666181017162459.

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Background:Isobutyrohydrazonoyl bromide 1 was used as a precursor for the synthesis of 4-imino-3-isopropyl-1-(4-nitrophenyl)-1,4-dihydro-5H-pyrazolo[3,4-d]pyrimidin-5-amine 4, which was converted into hydrazino derivative 5 by heating with hydrazine hydrate at reflux. Hydrazino, as well as imino-amino derivatives, underwent condensation and cyclization reactions to give pyrazolo[ 3,4-d]pyrimidine and pyrazolo[4,3-e][1,2,4]triazolo[3,4-c]pyrimidine derivatives, respectively.Method:Antimicrobial studies are performed using two-gram positive bacteria and two-gram negative bacteria.Results:Data re
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Hashem, Aya B., Olfat A. Nief, and Abdulkader M. Noori. "Synthesis, Characterization, and Antimicrobial Evaluation of Thiadiazole Derivatives Derived from 2-Amino-5-Thio-1,3,4-Thiadiazole." Iraqi Journal of Industrial Research 11, no. 2 (2024): 87–96. http://dx.doi.org/10.53523/ijoirvol11i2id402.

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This manuscript introduces a series of novel Schiff base and heterocyc-licring compounds, focusing on derivatives of 1,3-oxazepine and thiazo-lidinone.The derivative (2-Hydroxy-N-(5-mercapto-[1,3,4] thiadiazol-2-yl)-2-phenyl-acetamide was created by reacting ethyl mandelate ester[M1] and 2-amino-5-thio-1,3,4-thiadiazole compound to produce new compound [M2] and after that, compound [M2] was reacted with hydrazine hydrate 99% in dry DMF solvent, yielding the compound (N-(5-Hydrazino-[1,3,4]thiadiazol-2-yl)-2-hydroxy-2-phenyl-acetamide [M3]. In contrast , the Schiff base compound [M4] were synth
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Dissertations / Theses on the topic "Hydrazino derivatives"

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Clavette, Christian. "Synthesis of Beta-Aminocarbonyl Compounds and Hydrazine Derivatives Using Amino- and Imino-Isocyanates." Thesis, Université d'Ottawa / University of Ottawa, 2015. http://hdl.handle.net/10393/32004.

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Over the past recent years, β-aminocarbonyls have been of great interest to medicinal chemists. As a practical method to obtain these moieties, alkene aminocarbonylation, accounting for the formation of a C-N and a C-C bond, has been the subject of limited research efforts (very specific intramolecular metal-catalyzed variants have been reported). Direct aminocarbonylation of alkenes constitutes a challenging and an important potential innovation in the synthesis of β-aminocarbonyls such as β-amino acids. The research efforts described in the present thesis have been primarily directed towards
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Garland, Keira. "A Practical Approach to Semicarbazone and Hydrazone Derivatives via Imino-isocyanates." Thèse, Université d'Ottawa / University of Ottawa, 2014. http://hdl.handle.net/10393/30725.

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Isocyanates have a broad spectrum of uses and they are used in the production of many products including polyurethane polymers, coatings, adhesives, paints and foams. While isocyanates are widely studied and well represented in the literature, nitrogen substituted isocyanates are quite rare. Amino and imino-isocyanates are examples of nitrogen substituted isocyanates. Previous work within the group studied the reactivity of these intermediates in the alkene aminocarbonylation reaction, and used hydrazones and hydrazides as precursors of nitrogen substituted isocyanates. From there, a secon
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Yazici, Ceyda. "Synthesis Of 4-iodopyrazole Derivatives." Master's thesis, METU, 2008. http://etd.lib.metu.edu.tr/upload/3/12609750/index.pdf.

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Pyrazoles have been studied for over a century as an important class of heterocyclic compounds and continue to attract considerable interest due to the broad range of biological activities they possess. The electrophilic cyclization of the acetylenic hydrazones initiated by molecular iodine could provide new ways of synthesizing biologically active 4-iodopyrazole derivatives, which are important precursors for the synthesis of highly substituted pyrazole derivatives. For this reason, we investigated the synthesis of 4-iodopyrazole derivatives, such as 1-aryl- 5-alkyl/aryl-4-iodopyrazoles, star
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Mingle, David. "Synthesis, Characterization and Biological Evaluation of Novel (S,E)-11-[2-(Arylmethylene) Hydrazono] Pyrrolo [2,1-c] [1,4] Benzodiazepine Derivatives." Digital Commons @ East Tennessee State University, 2019. https://dc.etsu.edu/etd/3596.

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Pyrrolo [2,1-c] [1,4] benzodiazepine (PBD) is a class of natural products obtained from various actinomycetes which have both anti-tumor and antibiotic activities and can bind to specific sequences of DNA. PBD-dilactam was initially produced using isatoic anhydride and (L)-proline which was then converted to the PBD-thiolactam using Lawesson's reagent. Reaction of thiolactam with hydrazine in ethanol afforded PBD-11-hydrazinyl. Condensation of 11-hydrazinyl PBD with aldehydes possessing various substitutions was performed to obtain (S,E)-11-[2-(arylmethylene) hydrazono] pyrrolo [2,1-c] [1,4] b
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Mingle, David, and Abbas G. Dr Shilabin. "Synthesis, Characterization and Biological Evaluation of novel (S, E)-11-[2-(arylmethylene)hydrazono] pyrrolo [2,1-c] [1,4] benzodiazepine derivatives." Digital Commons @ East Tennessee State University, 2019. https://dc.etsu.edu/asrf/2019/schedule/212.

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Pyrrolo [2,1-c] [1,4] benzodiazepine (PBD) is a class of natural products obtained from various actinomycetes which have both anti-tumor and antibiotic activities. They can bind to specific sequences of DNA that can trigger a biological response which is of pharmacological interest. PBD can also prevent cell division leading to death of the bacteria. This research focuses on the synthesis of novel 11-hydrazinyl PBD derivatives using a multi-step synthesis. PBD-dilactam was initially produced using isatoic anhydride and (L)-proline which was then converted to the PBD-thiolactam using Lawesson's
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Gormen, Meral. "Synthesis Of Ferrocenyl Substituted Pyrazoles." Master's thesis, METU, 2005. http://etd.lib.metu.edu.tr/upload/3/12606358/index.pdf.

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Pyrazoles have been studied for over a century as an important class of heterocyclic compounds and continue to attract considerable interest due to the broad range of biological activities they possess. The incorporation of the essential structural features of pyrazoles with a ferrocene moiety could provide new derivatives with unexpected and/or enhanced biological activities since several ferrocene derivatives have already been shown to be active against a number of tumors. For this reason, we investigated the synthesis of ferrocenyl-substituted pyrazoles, such as 1-alkyl/aryl-5-ferrocenylpyr
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Hauke, Tobias [Verfasser], and Klaus T. [Akademischer Betreuer] Wanner. "Exploring 5-substituted nipecotic acid derivatives in the search for novel GABA uptake inhibitors by means of MS based screening of pseudostatic combinatorial hydrazone libraries / Tobias Hauke ; Betreuer: Klaus T. Wanner." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2018. http://d-nb.info/1178323943/34.

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Aumand, Livia M. "A Studies towards the formation of asymmetric quaternary centres via radical allylation B Applications of chiral hydrazide organocatalysts to Diels-Alder, hydride reduction, and alpha-chlorination reactions C Studies directed towards the synthesis of potential HIV-1 reverse transcriptase inhibitors: 9-Alkylaryl TIBO derivatives." Thesis, University of Ottawa (Canada), 2005. http://hdl.handle.net/10393/26843.

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In part A, the attempts at synthesizing quaternary centres via radical reactions are described. Using tartrate acetals as chiral auxiliaries, tertiary bromides were submitted to radical allylation conditions in an effort to form 1,3-dicarbonyl compounds 27 possessing an asymmetric quaternary centre at C2.* Part B describes the synthesis of chiral hydrazide 129 and its ability to catalyze the Diels-Alder reaction is examined. The application of chiral hydrazides 131 to the organocatalytic hydride reduction of alpha,beta-unsaturated aldehydes and the alpha-chlorination of aldehydes is also recou
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GUERRA, GIULIA. "Potential amphiphilic antibacterial compounds." Doctoral thesis, Università Politecnica delle Marche, 2020. http://hdl.handle.net/11566/274570.

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Perseguendo la ricerca di una nuova classe di peptidi antimicrobici strutturalmente semplici, abbiamo ottimizzato una sintesi breve, economica e ad alto rendimento di derivati dell'acido α-idrazido anfifilico monocarico, con azione membranolitica. Tali composti, hanno esibito un'attività in vitro ad ampio spettro contro una varietà di batteri Gram-positivi e Gram-negativi, tra cui due ceppi multi-farmaco resistenti. Inoltre, hanno mostrato effetti sinergici con la tetraciclina nei confronti dei batteri sensibili, mentre sono stati osservati effetti sinergici o indifferenza per combinazioni con
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Chen, Ci-Yuan, and 陳啟元. "Reactions of 4-ethoxyazulene derivatives with hydrazines, ethylenediamine and o-phenylenediamine." Thesis, 2005. http://ndltd.ncl.edu.tw/handle/65ud9k.

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碩士<br>中原大學<br>化學研究所<br>93<br>Abstract This thesis studies the formation of 4- ethoxy- 1- ethoxycarbonyl azulene, the synthesis of 4- ethoxy- 1- ethoxycarbonyl- 3- Razulene (formyl, acetyl, trifluoroacetyl), then 4- ethoxy-1- ethoxycarbonyl - 3-Razulene reacts with hydrazine, phenylhydrazine, ethylenediamine, o-phenlenediamine, afford five, seven, six member heterocyclic compound : 1-ethoxycarbonyl-5, 6-dihydro-5H-azuleno[1,8a,8-c,d]-1, 2-diazoine (30) , 1- ethoxycarbonyl- 3-methyl- 5,6- dihydroazuleno[1,8a,8-c,d] -1, 2- diazoine (35), 1-ethoxycarbonyl- 3- trifluoromethyl- 5,6-dihydroazuleno -
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Books on the topic "Hydrazino derivatives"

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Schmidt, Eckart W. Hydrazine and its derivatives: Preparation, properties, applications. 2nd ed. Wiley-Interscience, 2001.

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Patil, K. C., and Tanu Mimani Rattan, eds. Inorganic Hydrazine Derivatives. John Wiley & Sons, Ltd, 2014. http://dx.doi.org/10.1002/9781118693599.

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United States. National Aeronautics and Space Administration, ed. Catalysts for the decomposition of hydrazine and its derivatives, and a method for its production. National Aeronautics and Space Administration, 1986.

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Patil, K. C., and Tanu Mimani Rattan. Inorganic Hydrazine Derivatives: Synthesis, Properties and Applications. Wiley & Sons, Incorporated, John, 2014.

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Patil, K. C., and Tanu Mimani Rattan. Inorganic Hydrazine Derivatives: Synthesis, Properties and Applications. Wiley & Sons, Incorporated, John, 2014.

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Inorganic Hydrazine Derivatives: Synthesis, Properties and Applications. Wiley, 2014.

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Patil, K. C., and Tanu Mimani Rattan. Inorganic Hydrazine Derivatives: Synthesis, Properties and Applications. Wiley & Sons, Limited, John, 2014.

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Patil, K. C., and Tanu Mimani Rattan. Inorganic Hydrazine Derivatives: Synthesis, Properties and Applications. Wiley & Sons, Incorporated, John, 2014.

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Catalysts for the decomposition of hydrazine, hydrazine derivatives and mixtures of both. National Aeronautics and Space Administration, 1986.

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Nielsen, Robert Peter 1937. Study of the Synthesis of Some Aluminum and Phosphorus Derivatives of Alkyl Hydrazines. Creative Media Partners, LLC, 2021.

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Book chapters on the topic "Hydrazino derivatives"

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Aruna, Singanahally T., and K. C. Patil. "Hydrazine Salts." In Inorganic Hydrazine Derivatives. John Wiley & Sons, Ltd, 2014. http://dx.doi.org/10.1002/9781118693599.ch02.

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Rattan, Tanu Mimani, and K. C. Patil. "Hydrazine and Its Inorganic Derivatives." In Inorganic Hydrazine Derivatives. John Wiley & Sons, Ltd, 2014. http://dx.doi.org/10.1002/9781118693599.ch01.

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Gajapathy, Dasaratharam, and Tanu Mimani Rattan. "Metal Hydrazines." In Inorganic Hydrazine Derivatives. John Wiley & Sons, Ltd, 2014. http://dx.doi.org/10.1002/9781118693599.ch03.

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Patil, K. C., and Tanu Mimani Rattan. "Metal Hydrazine Carboxylates." In Inorganic Hydrazine Derivatives. John Wiley & Sons, Ltd, 2014. http://dx.doi.org/10.1002/9781118693599.ch04.

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Govindrajan, Subbiah, and Singanahally T. Aruna. "Hydrazinium Metal Complexes." In Inorganic Hydrazine Derivatives. John Wiley & Sons, Ltd, 2014. http://dx.doi.org/10.1002/9781118693599.ch05.

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Patil, K. C., and Tanu Mimani Rattan. "Applications of Inorganic Hydrazine Derivatives." In Inorganic Hydrazine Derivatives. John Wiley & Sons, Ltd, 2014. http://dx.doi.org/10.1002/9781118693599.ch06.

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Powis, Garth. "Triazine and Hydrazine Derivatives." In Cancer Management in Man. Springer Netherlands, 1989. http://dx.doi.org/10.1007/978-94-009-1095-9_9.

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Savelyev, Yu. "Polyurethane Thermoplastic Elastomers Comprising Hydrazine Derivatives: Chemical Aspects." In Handbook of Condensation Thermoplastic Elastomers. Wiley-VCH Verlag GmbH & Co. KGaA, 2006. http://dx.doi.org/10.1002/3527606610.ch13.

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Zalipsky, Samuel, and Sunitha Menon-Rudolph. "Hydrazide Derivatives of Poly(ethylene glycol) and Their Bioconjugates." In ACS Symposium Series. American Chemical Society, 1997. http://dx.doi.org/10.1021/bk-1997-0680.ch021.

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Pardasani, R. T., and P. Pardasani. "Molar magnetic moment of oxovanadium(IV) derivative with bis(hydrazone) derived from 1,1′-diacetylferrocene and isonicotinic acid hydrazide." In Magnetic Properties of Paramagnetic Compounds, Magnetic Susceptibility Data, Volume 1. Springer Berlin Heidelberg, 2021. http://dx.doi.org/10.1007/978-3-662-62478-4_41.

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Conference papers on the topic "Hydrazino derivatives"

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Quraishi, M. A. "Lauric Hydrazide Derivatives: New Class of Volatile Corrosion Inhibitors." In CORROSION 2002. NACE International, 2002. https://doi.org/10.5006/c2002-02319.

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Abstract The protection of metals against corrosion by means of volatile compounds is the most progressive method of fighting metallic corrosion. These inhibitors are used to protect metallic articles and equipment during storage and transportation. In view of this we have synthesized six organic volatile corrosion inhibitors (VCIs) using Lauric hydrazide with various acids such as cinnamic acid, succinic acid, nitrobenzoic acid, phthalic acid and maleic acid and evaluated their inhibiting action on corrosion of mild steel, copper, brass, zinc and aluminium by weight loss and potentiodynamic p
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Milenković, Dejan, Marko Antonijević, Edina Avdović, Dušica Simijonović, and Zoran Marković. "Design, in Silico Evaluation, and Toxicological Assessment of $N$-Protocatechoyl Hydrazone Derivatives as Potential EGFR Kinase Inhibitors." In 2024 IEEE 24th International Conference on Bioinformatics and Bioengineering (BIBE). IEEE, 2024. https://doi.org/10.1109/bibe63649.2024.10820446.

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Branković, Jovica, Zorica D. Petrović, and Vladimir P. Petrović. "In silico antibiofilm potency of phenolic N-acyl hydrazones against selected bacterial strains." In 2nd International Conference on Chemo and Bioinformatics. Institute for Information Technologies, University of Kragujevac, 2023. http://dx.doi.org/10.46793/iccbi23.495b.

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In the present work, fourteen phenolic hydrazone derivatives were evaluated for their in silico inhibitory activity against selected P. aeruginosa and S. maltophilia proteins involved in drug resistance and biofilm formation. Molecular docking analysis revealed the highest binding affinity of analogs n (-8.4 kcal/mol) and h (-7.3 kcal/mol) towards P. aeruginosa 7m1m and 7m1l proteins, respectively. In the case of S. maltophilia, analog k (-8.4 kcal/mol) expressed the highest binding affinity to 6qw7, whereas for 6uaf, the lowest binding energy was calculated for derivative d (-8.1 kcal/mol). T
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Antonijević, Marko, Žiko Milanović, Dušica Simijonović, Zoran Marković, and Snežana Marković S. Zoran. "ANTIOXIDATIVE POTENCY AND RADICAL SCAVENGING ACTIVITY OF SELECTED COUMARIN-HYBRIDS." In 1st INTERNATIONAL Conference on Chemo and BioInformatics. Institute for Information Technologies, University of Kragujevac,, 2021. http://dx.doi.org/10.46793/iccbi21.458a.

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In previous studies, it was found that coumarins with hydrazide moiety show good antioxidative potential, while similar coumarins with hydrazone moiety are good anticancer agents. In this paper, the antioxidative potency and radical scavenging activity of two coumarin hydrazone derivatives were investigated. For this purpose, density functional theory method M062X with 6-311G++(d,p) basis set was implemented. It was found that investigated compounds exhibit good antioxidative potency, with very similar BDE values regardless of the position involved. On the other hand, PA values show that a pre
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Blaja, Svetlana, Kaleria Kuchkova, Lidia Lungu, Vasile Lozovan, and Aculina Aricu. "Synthesis of hydrazide containing trinorlabdane derivatives." In New frontiers in natural product chemistry, scientific seminar with international participation. Institute of Chemistry, 2021. http://dx.doi.org/10.19261/nfnpc.2021.ab15.

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Zveaghinteva, Marina, Natalia Sucman, and Fliur Macaev. "Preparation of pyrazole class derivatives by heterocyclization of 1,2,4-triazolylethanones." In Conferința științifică națională cu participare internațională "Integrare prin cercetare și inovare", dedicată Zilei Internaționale a Științei pentru Pace și Dezvoltare. Moldova State University, 2025. https://doi.org/10.59295/spd2024n.93.

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In this work the peculiarities of the heterocyclization reaction of vinyltriazoles with the participation of hydrazine hydrate in ethanol and acetic acid are considered. Within the framework of this work it was found that the nature of the formed reaction products of the interaction of vinyltriazoles with hydrazine hydrate depends on the nature of the solvent. In boiling ethanol, 4,5-dihydro-1H-pyrazolinfunctionalized 1H-1,2,4-triazole is formed. Under acetic acid conditions, along with the formation of a pair of diastereomeric substances 4,5-dihydro-1H-pyrazoline series diastereomeric substan
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7

Branković, Jovica, Vesna Milovanović, and Vladimir P. Petrović. "CYCLOOXYGENASE-2 AS „IN SILICO“ TARGET OF PHENOLIC HYDRAZONE- TYPE DERIVATIVES." In 1st INTERNATIONAL Conference on Chemo and BioInformatics. Institute for Information Technologies, University of Kragujevac, 2021. http://dx.doi.org/10.46793/iccbi21.324b.

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In the present work, a series of phenolic hydrazone analogs were investigated in silico for their potential inhibitory activity toward COX-2. These examinations were based on the capability of hydrazone-based compounds to interact with numerous enzymes, as well as on their versatile biological features and therapeutical applications. COX-2 was selected due to its involvement in the inflammation and carcinogenesis processes. Regarding this, COX-2 represents a valid target for the development of compounds that could block the formation of harmful inflammation mediators.
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8

Krunić, Mihajlo J., Jelena Z. Penjišević, Slađana Kostić-Rajačić, Vladimir B. Šukalović, Deana B. Andrić, and Ivana I. Jevtić. "Pyrazole/tacrine derivatives as potential cholinesterase inhibitors." In 2nd International Conference on Chemo and Bioinformatics. Institute for Information Technologies, University of Kragujevac, 2023. http://dx.doi.org/10.46793/iccbi23.567k.

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Two new tacrine/pyrazole conjugates were designed, synthesized, and pharmacologically evaluated for their inhibitory activity toward acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). A scalable and cost-efficient synthetic route was developed, and key reaction steps for the synthesis of compounds 4a,b were nucleophilic substitution of α-aroylketene dithioacetals with tacrine intermediates, followed by cyclocondensation of respective N,S-acetals with hydrazine hydrate. The preliminary pharmacological evaluation revealed high inhibitory activities of 4a,b toward AChE (180 and 259 nM
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Popusoi, Ana, Nicanor Barba, and Aurelian Gulea. "Synthesis of 1,3-Phenyl(Pyridyl)propenones with thiosemicarbazidic groups." In Scientific seminar with international participation "New frontiers in natural product chemistry". Institute of Chemistry, Republic of Moldova, 2023. http://dx.doi.org/10.19261/nfnpc.2023.ab03.

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The bibliographic study of chalcones of the type 1,3-aryl(heteryl)propen-2-one with thiosemicarbazidic 4- and 1,4-disubstituted and thisemicarbazonic groups respectively gives us the information that they have a wide spectrum of biological activity, but methods of their synthesis are less described in the literature, and they became our object of study. 4,5-Dihydro-1-H-(pyrazol-3-yl)phenylhydrazinecarbothioamides 3a and 3b were obtained according to the following scheme:Reagents and reaction conditions: i, ii) 2-Py, 25oC – 24h, 90-95oC – 3h, 77-82%; iii) DMF, CH3COOH, 70-80oC, 2-3h, 60-63%. Fi
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Agafonova, N. A., E. V. Shchegolkov, Ya V. Burgart, V. I. Saloutin, and M. V. Ulitko. "Synthesis of biological active compounds based on trifluoromethylcontaining 4-nitrosopyrazoles." In VIII Information school of a young scientist. Central Scientific Library of the Urals Branch of the Russian Academy of Sciences, 2020. http://dx.doi.org/10.32460/ishmu-2020-8-0009.

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e-pot nitrosation of 1,3-diketones or their lithium salts followed by treatment of hydrazines. Reduction of the nitroso-derivatives made it possible to obtain the 4-amino-3-trifluoromethylpyrazoles chlorides. Cytotoxic activity of the compounds wase evaluated in vitro
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