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Journal articles on the topic 'Hydrazino derivatives'

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Published: 5 June 2025

Last updated: 1 August 2025

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1

Ibrahim, Hassan K., Sayed H. El-Tamany, Reda F. El-Shaarawy, and Ibrahim M. El-Deen. "Synthesis and investigation of mass spectra of some novel benzimidazole derivatives." Macedonian Journal of Chemistry and Chemical Engineering 27, no. 1 (2008): 65. http://dx.doi.org/10.20450/mjcce.2008.248.

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2-Substituted benzimidazoles (3) and (4a-c) were prepared via condensation of ethyl 2-thionyl-pyruvate (1) and hydrazidoyl derivatives (2a-c) with o-phenylene diamine in acetic acid. Acetylation of compound (4a) with acetic anhydride yielded the corresponding N-acetyl derivative (5). Treatment of compound 4b with hydrazine hydrate gave the corresponding hydrazino derivative (6). Reaction of 2-[(2-thionyl)acetyl)] benzimidazole (3) with hydrazine hydrate gave the pyrazolyl derivative (7) and hydrazino derivative (8). Alkylation of compound 3 with alkyl halide gave the corresponding 2,3-disubsti

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2

Hossain, M. I., and M. M. H. Bhuiyan. "Synthesis and Antimicrobial Activities of Some New Thieno and Furopyrimidine Derivatives." Journal of Scientific Research 1, no. 2 (2009): 317–25. http://dx.doi.org/10.3329/jsr.v1i2.2299.

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Fused pyrimidines, 8,9-dimethyl[1,2,4]triazolo[4,3-c]thieno[3,2-e]pyrimidine 5, 3,8,9-trimethyl[1,2,4]triazolo[4,3-c]thieno[3,2-e]pyrimidine 6, 4-benzylidinehydrazono-5,6 dimethylthieno[2,3-d]pyrimidine 7, 4-[4/-hydroxybenzylidine]hydrazono-5,6-dimethylthi-eno[2,3-d]pyrimidine 8, 4-[4/-tolylidin]hydrazono-5,6-dimethylthieno[2,3-d]pyrimidine 9, 4-[4/-nitrobenzylidine]hydrazono-5-ethyl-6-methylthieno[2,3-d]pyrimidine 10 and 4-[4/-chlorobenzylidine]hydrazono-5-ethyl-6-methylthieno[2,3-d]pyrimidine 11 are prepared in good yield by an initial treatment of 2-amino-4,5-dimethylthiophene-3-carbonitril

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3

Edrees, Mastoura M. "Synthesis of 4-hydrazinopyrazolo[3,4-d]pyrimidines and their Reactions with Carbonyl Compounds." Journal of Chemical Research 37, no. 1 (2013): 6–10. http://dx.doi.org/10.3184/174751912x13543818811749.

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Synthesis of a new 4-hydrazinopyrazolo[3,4- d]pyrimidine was achieved via heating (4,6-dithioxo-1 H-pyrazolo[3,4- d] pyrimidin-3-yl)acetonitrile with hydrazine hydrate. Reactions of the latter product with thiophene-2-carbaldehyde and ethyl hydrazonoacetoacetate analogues afforded the corresponding hydrazone and pyrazole derivatives, respectively. Similarly, condensation of 2-[6-(benzylsulfanyl)-4-hydrazino-1 H-pyrazolo[3,4- d]pyrimidin-3-yl]acetonitrile with thiophene-2-carbaldehyde and ethyl hydrazonoacetoacetate analogues gave the respective hydrazone and pyrazolone derivatives. Alkylation

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4

Metwally, Mohamed Abbas, and M. A. Sofan. "Synthesis of Some New Pyrrolo Heterocycles of Pharmaceutical Interest from 1,4-Diphenylpyrrolidine-2,3,5-trione+." Zeitschrift für Naturforschung B 45, no. 3 (1990): 382–84. http://dx.doi.org/10.1515/znb-1990-0313.

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Continuing earlier studies designed to obtain derivatives of pharmacological interest, some novel compounds 2, 5, 6, 7 and 8 were prepared using 1,4-diphenylpyrrolidine-2,3,5-trione (1) and 1,2-phenylenediamines, o-aminophenol, 1,3-diphenylacetone and thiosemicarbazide, respectively. The hydrazino derivative (8) was obtained from 7 and hydrazine hydrate. Structural identification was obtained by 1H NMR, mass spectra and IR spectral data.

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5

Journal, Baghdad Science. "Synthesis of Some Heterocyclic Compounds Derived from 2-Mercapto Benzoxazole." Baghdad Science Journal 10, no. 3 (2013): 766–78. http://dx.doi.org/10.21123/bsj.10.3.766-778.

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New series of 2-mecapto benzoxazole derivatives (1-20) incorporated into fused to different nitrogen and suphur containing heterocyclic were prepared from 2-meracpto benzoxazole, when treated with hydrazine hydrate to afford 2-hydrazino benzoxazol (1). Compound (1) converted to a variety of pyridazinone andphthalazinone derivatives (2-4) by reaction with different carboxylic anhydride. Also, reaction of (1) with phenyl isothiocyanate and ethyl chloro acetate afforded 3-phenyl-1,3-thiazolidin-2,4-dione-2-(benzoxazole-2-yl-hydrazone) (6). Azomethines (7-10) were prepared through reaction of (1)

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6

Askar, Firyal W., Huda A. Hassan, and Nahida A. Jinzeel. "Synthesis of Some Heterocyclic Compounds Derived from 2-Mercapto Benzoxazole." Baghdad Science Journal 10, no. 3 (2013): 766–78. http://dx.doi.org/10.21123/bsj.2013.10.3.766-778.

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New series of 2-mecapto benzoxazole derivatives (1-20) incorporated into fused to different nitrogen and suphur containing heterocyclic were prepared from 2-meracpto benzoxazole, when treated with hydrazine hydrate to afford 2-hydrazino benzoxazol (1). Compound (1) converted to a variety of pyridazinone andphthalazinone derivatives (2-4) by reaction with different carboxylic anhydride. Also, reaction of (1) with phenyl isothiocyanate and ethyl chloro acetate afforded 3-phenyl-1,3-thiazolidin-2,4-dione-2-(benzoxazole-2-yl-hydrazone) (6). Azomethines (7-10) were prepared through reaction of (1)

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7

Alheety, Nuaman. "Synthesis, Characterization and Antimicrobial Activity Study of Some New Substituted Benzoxazole Derivatives." Baghdad Science Journal 16, no. 3 (2019): 616. http://dx.doi.org/10.21123/bsj.2019.16.3.616.

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This research included the preparation of 2-mercaptobenzoxazole (N1) by the reaction of ortho-aminophenol with carbon disulfide in an alcoholic potassium hydroxide solution. The 2-mercapto benzoxazole (N1) was then treated with hydrazine to obtain the 2-hydrazino benzoxazole (N2). A number of hydrazones (N3-N5) were prepared through the reaction of N2 with different benzaldehydes. The compound (N6) was also prepared whereby the ring closing of hydrazone (N3) using chloroacetylchloride, while the compound (N7) was prepared by treating 2-hydrazino benzoxazole with acetylacetone. When the compoun

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8

ABDUL, U. SIDDIQUI, H. SIDDIQUI A., and SUNDARA RAMAIAH T. "Synthesis of Steroidal and Terpenoidal Extranucleo Thiazolidinones." Journal of Indian Chemical Society Vol. 69, Feb 1992 (1992): 85–86. https://doi.org/10.5281/zenodo.5993007.

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Department of Chemistry, Nizam College, Osmania University, Hyderabad-500 001 <em>Manuscript received 26 December 1991, accepted 17 February 1992</em> 3-Oxo-5β-cholan-24-oic-acid (la), 3-oxo-lanost-8,24-diene (2a) and 3-oxo-olean-12-ene (3a) on reaction with hydrazine hydrate in alcoholic solution gave the respective 3-hydrazones (lb, 2b and 3b). Subsequent reaction of these 3-hydrazones with ammonium thiocyanate in benzene solution afforded 3-thiosemicarbazone derivatives (lc, 2c and 3c) which undergo cyclisation with chloroacetic acid in the presence of anhydrous sodium acetate to yield

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9

Hassaneen, Hamdi M., Fatma M. Saleh, Tayseer A. Abdallah, et al. "Synthesis, Cytotoxicity, Antimicrobial and Docking Simulation of Novel Pyrazolo[3,4-d]pyrimidine and pyrazolo[4,3-e][1,2,4]triazolo[3,4-c] pyrimidine Derivatives." Mini-Reviews in Medicinal Chemistry 19, no. 8 (2019): 657–70. http://dx.doi.org/10.2174/1389557518666181017162459.

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Background:Isobutyrohydrazonoyl bromide 1 was used as a precursor for the synthesis of 4-imino-3-isopropyl-1-(4-nitrophenyl)-1,4-dihydro-5H-pyrazolo[3,4-d]pyrimidin-5-amine 4, which was converted into hydrazino derivative 5 by heating with hydrazine hydrate at reflux. Hydrazino, as well as imino-amino derivatives, underwent condensation and cyclization reactions to give pyrazolo[ 3,4-d]pyrimidine and pyrazolo[4,3-e][1,2,4]triazolo[3,4-c]pyrimidine derivatives, respectively.Method:Antimicrobial studies are performed using two-gram positive bacteria and two-gram negative bacteria.Results:Data re

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10

Hashem, Aya B., Olfat A. Nief, and Abdulkader M. Noori. "Synthesis, Characterization, and Antimicrobial Evaluation of Thiadiazole Derivatives Derived from 2-Amino-5-Thio-1,3,4-Thiadiazole." Iraqi Journal of Industrial Research 11, no. 2 (2024): 87–96. http://dx.doi.org/10.53523/ijoirvol11i2id402.

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This manuscript introduces a series of novel Schiff base and heterocyc-licring compounds, focusing on derivatives of 1,3-oxazepine and thiazo-lidinone.The derivative (2-Hydroxy-N-(5-mercapto-[1,3,4] thiadiazol-2-yl)-2-phenyl-acetamide was created by reacting ethyl mandelate ester[M1] and 2-amino-5-thio-1,3,4-thiadiazole compound to produce new compound [M2] and after that, compound [M2] was reacted with hydrazine hydrate 99% in dry DMF solvent, yielding the compound (N-(5-Hydrazino-[1,3,4]thiadiazol-2-yl)-2-hydroxy-2-phenyl-acetamide [M3]. In contrast , the Schiff base compound [M4] were synth

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11

Wasfy, Ashraf A. F., Mohamed M. H. Arief, Mahassen S. Amine, Shafey G. Donia та Aly A. Aly. "γ-Oxo Carboxylic Acids in Heterocyclic Synthesis, III. Synthesis of Biologically Active 4-Benzylamino-6-(5,5-dioxodibenzothiophen- 2-yl)-2,3,4,5-tetrahydropyridazin-3-ones". Zeitschrift für Naturforschung B 57, № 6 (2002): 668–76. http://dx.doi.org/10.1515/znb-2002-0613.

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α-Benzylamino-β-(5,5-dioxodibenzothiophen-2-carbonyl)propionic acid (1) has been synthesized by treating the corresponding β-aroylacrylic acid with benzylamine in dry benzene. On treatment with hydrazine hydrate the keto acid 1 furnishes the corresponding pyridazinone derivative 2. The behaviour of 2 towards carbon electrophiles, namely, ethyl chloroacetate, acrylonitrile, formaldehyde and secondary amines (under Mannich reaction conditions), aromatic aldehydes and carbon nucleophiles, namely, POCl3/PCl3 and P2S5 has been investigated. The 3-chloropyridazine derivative 13 reacts with hydrazine

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12

Sadasivan Nair, Vijayakumar, Sharafudeen Kaniyarakkal, Shiju Edappadikkunnummal, et al. "Reverse Saturable Absorption in Substituted Hydrazones and Its Structure-Property Relationship for Photonic Applications." Laser and Particle Beams 2022 (May 13, 2022): 1–8. http://dx.doi.org/10.1155/2022/3382780.

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The third-order nonlinear optical properties of three hydrazone derivatives, namely, ethyl 2-((2E)-2-(4-(dimethylamino)benzylidene]hydrazinyl)-5-nitrobenzoate, ethyl 2-((2E)-2-(4-chlorobenzylidene)hydrazino)-5-nitrobenzoate, and methyl 5-nitro-2-((2E)-2-(4-nitrobenzylidene)hydrazino)benzoate were investigated by the single beam Z-scan technique with nanosecond laser pulses at 532 nm. The compounds were doped into PMMA (poly (methyl methacrylate)), and their third-order nonlinearity was studied with a prospective of reaching a compromise between processability and high nonlinear optical behavio

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13

Ibtehal K. Abdullah and Meaad K. Buniya. "Preparation and Identification of some heterocyclic compounds from cyano compounds." Tikrit Journal of Pure Science 20, no. 5 (2023): 96–105. http://dx.doi.org/10.25130/tjps.v20i5.1245.

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This article included prepared cyano acetic acid hydrazid from interaction cyano ethylacetate with hydrate hydrazen, and interaction with 2- acytel thiophene and 2- acytelpyridine it will formation of hydrazide- hydrazone derivative (I, II), and through the undergo the compounds (I,II) for chain of interactions with different chemical materials then enclosed cyclo formed derivative of (arylidene ,coumarin , aryl hydrazon , thiophene ) . Prepared compounds have been studied and Identification by physical and spectral means.

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14

Xu, Silong, Jian Shang, Junjie Zhang та Yuhai Tang. "Regioselective SN2' Mitsunobu reaction of Morita–Baylis–Hillman alcohols: A facile and stereoselective synthesis of α-alkylidene-β-hydrazino acid derivatives". Beilstein Journal of Organic Chemistry 10 (30 квітня 2014): 990–95. http://dx.doi.org/10.3762/bjoc.10.98.

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A highly regioselective SN2' Mitsunobu reaction between Morita–Baylis–Hillman (MBH) alcohols, azodicarboxylates, and triphenylphosphine is developed, which provides an easy access to α-alkylidene-β-hydrazino acid derivatives in high yields and good stereoselectivity. This reaction represents the first direct transformation of MBH alcohols into hydrazines.

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15

Mahmoud, M. R., A. A. Shalaby, T. A. Gad, and A. A. El-Khamry. "A facile synthesis and heteroannulation of pyrido[2,3-d]pyrimidine and related heterocyclic systems." Journal of Chemical Research 2009, no. 10 (2009): 612–15. http://dx.doi.org/10.3184/030823409x12523324765777.

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7-Amino-1,2,3,4-tetrahydro-4-oxo-2-thioxo-5-(3,4,5-trimethoxyphenyl)pyrido[2,3- d]pyrimidine (1) was prepared and reacted with methyl iodide and ethyl chloroacetate to give the S-alkylated products 2 and 3, respectively. The reaction of 1 or 3 with hydrazine hydrate yielded the same 2-hydrazino derivative 4. Treatment of 4 with 2,4-pentanedione, 2-acetylcyclohexanone and ethyl acetoacetate afforded the corresponding pyrazolylpyrido[2,3- d]pyrimidine derivatives (5–7), while phthalic anhydride gave the phthalazinyl compound 8. Ethoxymethylenemalononitrile with the hydrazine 4 formed the fused 1

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16

ELSAYED, H. ELTAMANY. "Reactivity of 1-Chlorobenzo[g]phthalazinone and 1 ,4-Dichlorobenzo[g]phthalazine towards some Nucleophilic Reagents." Journal of Indian Chemical Society Vol. 74, Jan 1997 (1997): 21–23. https://doi.org/10.5281/zenodo.5876684.

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Chemistry Department, Faculty of Science, Suez Canal University, Ismailia, Egypt <em>Manuscript received 10 April 1995, accepted 6 July 1995</em> 1-Chlorobenzoi dphthalazinone (2) and 1,4-dichlorobenzoi [g]phthalazine (3) have been synthesised by the reaction of 1,2,3,4- tetrahydrophthalazine-2,4-dione (1) with phosphorus oxychloride. The chlorine atoms can be replaced by nucleophilic reagents such as morpholine, cyanide, amines, alkoxide, azide and hydrazine to give the corresponding products. Treating of hydrazino derivative (4) with formic acid afforded triazolophthalazinone derivative (5),

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17

Sekgota, Khethobole C., Michelle Isaacs, Heinrich C. Hoppe, et al. "Propylphosphonic acid anhydride–mediated amidation of Morita–Baylis–Hillman–derived indolizine-2-carboxylic acids." Journal of Chemical Research 45, no. 7-8 (2021): 674–78. http://dx.doi.org/10.1177/1747519820987156.

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Propylphosphonic acid anhydride has been successfully used as a coupling agent in the synthesis of a series of indolizine-2-carboxamido derivatives from indolizine-2-carboxylic acid and its 3-acetylated analogue. The acid substrates were obtained by saponification of the corresponding methyl esters produced, in turn, selectively and efficiently, by time-controlled cyclisation of a single Morita–Baylis–Hillman adduct. Various amino and hydrazino compounds with medicinal potential have been used to prepare indolizine-2-carboxamido and hydrazido derivatives.

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18

Salam, Osama I. Abdel, Mohamed A. Al-Omar, Nagy M. Khalifa, Abd El-Galil E. Amr, and Mohamed M. Abdallah. "Analgesic and Anticonvulsant Activities of Some Newly Synthesized Trisubstituted Pyridine Derivatives." Zeitschrift für Naturforschung C 68, no. 7-8 (2013): 264–68. http://dx.doi.org/10.1515/znc-2013-7-802.

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A series of novel pyridine carbohydrazide derivatives were synthesized from the reaction of 2-chloro-6-hydrazino-isonicotinic acid hydrazide with selected active reagents. All prepared compounds were tested as analgesic and anticonvulsant agents. The pharmacological screening showed that many of these compounds have good activities comparable to those of valdecoxib and carbamazepine as reference drugs

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19

Abdelazeem, Ahmed H., Yasser M. A. Mohamed, Ahmed M. Gouda, Hany A. Omar, and Majed M. Al Robaian. "Novel Thymohydroquinone Derivatives as Potential Anticancer Agents: Design, Synthesis, and Biological Screening." Australian Journal of Chemistry 69, no. 11 (2016): 1277. http://dx.doi.org/10.1071/ch16102.

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The safety and efficacy of naturally occurring anticancer agents and their derivatives such as thymoquinone (TQ) and thymohydroquinone (THQ) have gained a rapidly growing interest. In an attempt to develop novel anticancer agents with superior activity, TQ was allowed to react with hydrazine hydrate, producing hydrazino thymohydroquinone 3. This new intermediate was subsequently reacted with various isocyanates, isothiocyanates, and acyl halides, affording three series of semicarbazone, semithiocarbazone, and acyl hydrazone derivatives, respectively. Subsequently, the anticancer activity of al

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20

Abdelazeem, Ahmed H., Yasser M. A. Mohamed, Ahmed M. Gouda, Hany A. Omar, and Majed M. Al Robaian. "Corrigendum to: Novel Thymohydroquinone Derivatives as Potential Anticancer Agents: Design, Synthesis, and Biological Screening." Australian Journal of Chemistry 70, no. 6 (2017): 755. http://dx.doi.org/10.1071/ch16102_co.

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The safety and efficacy of naturally occurring anticancer agents and their derivatives such as thymoquinone (TQ) and thymohydroquinone (THQ) have gained a rapidly growing interest. In an attempt to develop novel anticancer agents with superior activity, TQ was allowed to react with hydrazine hydrate, producing hydrazino thymohydroquinone 3. This new intermediate was subsequently reacted with various isocyanates, isothiocyanates, and acyl halides, affording three series of semicarbazone, semithiocarbazone, and acyl hydrazone derivatives, respectively. Subsequently, the anticancer activity of al

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21

Mohamed, Mosaad, Samir Awad, and Naglaa Ahmed. "Synthesis and antimicrobial evaluation of some 6-aryl-5-cyano-2-thiouracil derivatives." Acta Pharmaceutica 61, no. 2 (2011): 171–85. http://dx.doi.org/10.2478/v10007-011-0019-1.

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Synthesis and antimicrobial evaluation of some 6-aryl-5-cyano-2-thiouracil derivativesA series of 6-aryl-5-cyano-2-thiouracil derivatives (1a-d) was synthesized by the reaction of ethyl cyanoacetate with thiourea and aldehydes. These products were used as intermediate compounds for the synthesis of a number of thiouracil derivatives (2a-dto10a-d). All compounds were screened for antibacterial and antifungal activities. Some of the prepared compounds, 6-(4-fluorophenyl)-4-oxo-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide (2a), 4-oxo-2-thioxo-6-(3,4,5-trimethoxyphenyl)-1,2,3,4-tetrahydropy

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22

El-Naggar, Mohamed, Abd El-Galil E. Amr, Ahmed A. Fayed, Elsayed A. Elsayed, Mohamed A. Al-Omar, and Mohamed M. Abdalla. "Potent Anti-Ovarian Cancer with Inhibitor Activities on Both Topoisomerase II and V600EBRAF of Synthesized Substituted Estrone Candidates." Molecules 24, no. 11 (2019): 2054. http://dx.doi.org/10.3390/molecules24112054.

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A series of 16-(α-alkoxyalkane)-17-hydrazino-estra-1(10),2,4-trien[17,16-c]-3-ol (3a–l) and estra-1(10),2,4-trien-[17,16-c]pyrazoline-3-ol derivatives (4a–d) were synthesized from corresponding arylidines 2a,b which was prepared from estrone 1 as starting material. Condensation of 1 with aldehydes gave the corresponding arylidine derivatives 2a,b which were treated with hydrazine derivatives in alcohols to give the corresponding derivatives 3a–l, respectively. Additionally, treatment of 2a,b with methyl- or phenylhydrazine in ethanolic potassium hydroxide afforded the corresponding N-substitut

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23

Al-Syari, Abdulkarim H., and Saieba S. Hassan. "Synthesis and Spectroscopic Study of Some New 1,2,4-Triazino[5,6-b]indole Derivatives." Thamar University Journal of Natural & Applied Sciences 2, no. 2 (2023): 57–68. http://dx.doi.org/10.59167/tujnas.v2i2.1274.

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The Scheme of this work included the synthesis and characterization of new two series of 1,2,4-triazino[5,6-b] indole and 8-bromo-1,2,4-triazino[5,6-b] indole derivatives according to the starting material used. Both, derivatives of 3-thione-1,2,4-triazino[5,6-b] indole and 8-bromo-3-thione-1,2,4-triazino[5,6-b] indole (3a & 3b) were prepared by using Isatin and 5-bromo isatin as a starting material, the new schiff`s bases (5a & 5b) were synthesized by the reaction of hydrazino indole derivatives (4a & 4b) with aromatic aldehydes. Tetracyclic derivatives (7a & 7b) were prepared

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S., Guru, Yadav R., Srivastava Soumya, K. Srivastava S., and D. Srivastava S. "Synthesis of some new N1-[(2-oxo-3-chloro-4-aryl-azitidin)-(acetyl amino)]-indole derivatives and their pharmacological activity." Journal of Indian Chemical Society Vol. 83, Dec 2006 (2006): 1236–124. https://doi.org/10.5281/zenodo.5834026.

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Synthetic Organic Chemistry Laboratory, Department of Chemistry, Dr. H. S. Gour University, Sagar-470 003, Madhya Pradesh, India <em>E-mail </em>: professorsks@rediffmail.com <em>Manuscript received 17 March 2006, revised 25 July 2006, accepted 7 September 2006</em> Indole on reaction with chloroacetyl chloride afforded N<sup>1</sup>-(1-chloro acetyl)-indole which was renuxed with hydrazine hydrate to give <em>N</em><sup>1</sup>-[(1-hydrazino)acetyl]-indole. The hydrazino derivative of indole was further treated with various substituted aromatic carbonyls to get <em>N</em><sup>1</sup>-[(benzyl

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25

Abass, Mohamed, Mostafa Ismail, Wafaa Abdel-Monem, and Aisha Mayas. "Substituted pyridopyrimidinones, Part IV: 2-chloro-4h-pyrido[1,2-a]pyrimidin-4-one as a synthone of some new heterotricycles." Journal of the Serbian Chemical Society 75, no. 1 (2010): 11–17. http://dx.doi.org/10.2298/jsc1001011a.

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2-Chloro-4H-pyrido[1,2-a]pyrimidin-4-one (1) was utilized as a synthone precursor to prepare novel heterotricyclic systems. 2-Azido and 2-hydrazino derivatives (2 and 3) were obtained by nucleophilic replacement evolving compound 1. The hydrazine derivative 3 was transformed into the azido derivative 2 by nitrosation. Treatment of compound 3 with [bis(methylthio)methylene] malononitrile afforded 2-pyrazolylpyridopyrimidine 4. When compound 1 was reacted with 5-amino-3-(methylthio)-1H-pyrazole-4-carbonitrile, the same compound 4 was obtained with no evidence for the production of (pyrazolylamin

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Journal, Baghdad Science. "Synthesis of Some Heterocyclic Compounds derived from 2-mercapto pyrimidine." Baghdad Science Journal 7, no. 2 (2010): 1014–22. http://dx.doi.org/10.21123/bsj.7.2.1014-1022.

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In this work 2-hydrazino pyrimidine (1) was prepared from 2-mercapto pyrimidine with hydrazine hydrate. Treatment of (1) with active methylene compounds gave 2-(3,5-dimethyl -1 H – Pyrazole-1-yl) pyrimidine , whereas the reaction of (1) with carboxylic anhydride namely maleic anhydride or 1,2,3,6-tetra hydro phthalic anhydride yielded 1-Pyrimidine-2-yl-1,2-dihydro pyridazine-3,6-dione (3) and 2 – Pyrimidin -2-yl -2,3,4 a ,5,8 a – hexahydro phthalazine 1,4 – dione (4) . Reaction of (1) with phenyl isothiocyanate and ethyl chloro acetate afforded 3-Phenyl-1,3-thiazolidine-2,4-dione-2( pyrimidine

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Askar, Firyal w., Huda A. Hassan, and Nahida A. Jinzeel. "Synthesis of Some Heterocyclic Compounds derived from 2-mercapto pyrimidine." Baghdad Science Journal 7, no. 2 (2010): 1014–22. http://dx.doi.org/10.21123/bsj.2010.7.2.1014-1022.

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In this work 2-hydrazino pyrimidine (1) was prepared from 2-mercapto pyrimidine with hydrazine hydrate. Treatment of (1) with active methylene compounds gave 2-(3,5-dimethyl -1 H – Pyrazole-1-yl) pyrimidine , whereas the reaction of (1) with carboxylic anhydride namely maleic anhydride or 1,2,3,6-tetra hydro phthalic anhydride yielded 1-Pyrimidine-2-yl-1,2-dihydro pyridazine-3,6-dione (3) and 2 – Pyrimidin -2-yl -2,3,4 a ,5,8 a – hexahydro phthalazine 1,4 – dione (4) . Reaction of (1) with phenyl isothiocyanate and ethyl chloro acetate afforded 3-Phenyl-1,3-thiazolidine-2,4-dione-2( pyrimidine

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M., B. Deshmukh, Patil Suresh, D. Jadhav S., and Y. Mane S. "Synthesis of some new 2-substituted quinazoline derivatives." Journal of Indian Chemical Society Vol. 88, Mar 2011 (2011): 451–55. https://doi.org/10.5281/zenodo.5766087.

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Department of Chemistry, Shivaji University, Kolhapur-416 004, Maharashtra, India Padmabhushan Dr. Vasantraodada Patil Mahavidyalaya, Tasgaon, Dist. Sangli, Maharashtra, India <em>E-mail</em> : sanyujapatil@yahoo.com <em>Manuscript received 17 February 2009, revised 08 July 2010, accepted 20 July 2010</em> 2-(2' -Amino-4' -methylpyrimidine-5-yl sulfanyl)·3-arylquinazolin-4(3H)ones (4) have been obtained by reaction of compound 3 with guanidine. Condensation of hydrazino derivatives (6) with variously substituted aryl aldehydes gave 2-(arylidenehydrazinomethyloxoethylthio)&middot

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El-Faham, Ayman, Wael N. Hozzein, Mohammad A. M. Wadaan, et al. "Microwave Synthesis, Characterization, and Antimicrobial Activity of Some Novel Isatin Derivatives." Journal of Chemistry 2015 (2015): 1–8. http://dx.doi.org/10.1155/2015/716987.

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Three series of isatin derivatives [3-hydrazino, 3-thiosemicarbazino, and 3-imino carboxylic acid derivatives] were synthesized employing microwave irradiation. The prepared compounds were characterized by FT-IR, NMR, elemental analysis, and X-ray crystallography for derivatives5b. The synthesized compounds were screened for antimicrobial activity against selected bacteria and fungi. The results revealed that theN-alkyl isatin derivatives were biologically active with different spectrums activity. Most of the 3-hydrazino and 3-thiosemicarbazino isatin derivatives were biologically inactive and

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Sharma, Neetesh Kumar, and Raghvendra Singh Bhadauria. "Synthesis and Biological Evaluation of 1-(6-bromobenzo [d]thiazol-2-yl)-2-(disubstituted methylene) hydrazine derivatives." Journal of Drug Delivery and Therapeutics 9, no. 4-A (2019): 577–86. http://dx.doi.org/10.22270/jddt.v9i4-a.3520.

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Synthesis of a series of various 1-(6-bromobenzo[d]thiazol-2-yl)-2-(disubstitutedmethylene)hydrazine derivatives (7a-7e)have been done. Synthesis of a series of intermediates (3 and 5) have been also done, 6-bromo-1,3-benzothiazole-2-amine (3), 2-hydrazino-6-bromo-1, 3-benzothiazole (5) and final product (7a-7e), 1-(6-bromobenzo[d]thiazol-2-yl)-2-(diphenylmethylene) hydrazine (7a), 1-(6-bromobenzo [d]thiazol-2-yl)-2-(propan-2-ylidene) hydrazine (7b), (E)-2-(butan-2-ylidene)-1-(6-bromobenzo[d]thiazol-2-yl)hydrazine (7c), (Z)-1-(6-bromobenzo[d]thiazol-2-yl)-2-(cyclohexylmethylene) hydrazine (7d)

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Sharma, Neetesh Kumar, and Raghvendra Singh Bhadauria. "Synthesis and Biological Evaluation of 1-(6-chlorobenzo [d]thiazol-2-yl)-2-(disubstituted methylene) hydrazine derivatives." Journal of Drug Delivery and Therapeutics 9, no. 4-A (2019): 561–72. http://dx.doi.org/10.22270/jddt.v9i4-a.3515.

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Synthesis of a series of various 1-(6-chlorobenzo[d]thiazol-2-yl)-2-(disubstitutedmethylene)hydrazine derivatives (7a-7e)have been done. Synthesis of a series of intermediates (3 and 5) have been also done, 6-Chloro-2-amine-1,3-benzothiazole (3), 2-hydrazino-6-chloro-1, 3-benzothiazole (5) and final product (7a-7e), 1-(6-chlorobenzo[d]thiazol-2-yl)-2-(diphenylmethylene) hydrazine (7a), 1-(6-chlorobenzo [d]thiazol-2-yl)-2-(propan-2-ylidene) hydrazine (7b), (E)-2-(butan-2-ylidene)-1-(6-chlorobenzo[d]thiazol-2-yl)hydrazine (7c), (Z)-1-(6-chlorobenzo[d]thiazol-2-yl)-2-(cyclohexylmethylene) hydrazi

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32

Sangeeta, Mehrotra, Pandey Vaishali, Lakhan Ram, and K. Srivastava P. "Synthesis and antibacterial activities of 1-(p-chloropheny1)- 2-amino/hydrazino-4-nitrophenyl/p-chloropheny1)-1,6-dihydro ¬1,3,5-triazine-6-thiones and related thiocarbamides, thiosemicar- bazides and Schiff bases." Journal of Indian Chemical Society Vol. 79, Feb 2002 (2002): 176–78. https://doi.org/10.5281/zenodo.5873172.

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Department of Chemistry, Banaras Hindu University, Varanasi-221 005, India  <em>Fax : </em>91-542-368174 <em>Manuscript received 27 November 2000, revised 19 March 2001. accepted 5 June 2001</em> 1-(p-ChlorophenyI)-2-benzylmercapto-4-0-nitrophenyl/p-chloropheny1)-1,6-dihydro-1,3,5-trazine-6-thiones (1) on treatment with ammonia/hydrazine hydrate under suitable conditions afford the corresponding 2-amino/hydrazino derivatives (2, 3). The latter on treatment with aryl isothiocyanates/aryl aldehydes afford the related thiocarbamides/thiosemicarbazides/Schiff bases (4.6) which have been

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33

Ashry, El Sayed H. El, Hamida Abdel Hamid, Ahmed Mousaad, and El Sayed Ramadan. "Regioisomeric Formation of the Linear 1,2,4-Triazolo[4′,3′: 2,3][1,2,4]Triazino[5,6-b]Indole from 3-Hydrazino-1,2,4-Triazino[5,6-b]Indole Derivatives." Journal of Chemical Research 2002, no. 7 (2002): 314–16. http://dx.doi.org/10.3184/030823402103172284.

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Oxidative cyclisation of the ethylidene derivatives of 5-allyl-3-hydrazino-1,2,4-triazino[5,6-b]indole (7) and 8-bromo-3-hydrazino-5H-1,2,4-triazino[5,6-b]indole (8) gave regioselectively the linear isomers, 10-allyl-3-methyl-1,2,4-triazolo[4′,3′:2,3][1,2,4]triazino[5,6-b]indole (15) and 7-bromo-3-methyl-10H-1,2,4-triazolo[4′,3′:2,3][1,2,4]triazino-[5,6-b]indole (16), respectively. They were also obtained by the dehydrative cyclisation of 5 and 6 respectively with acetic acid as well as by the condensation of the N-allyl- (22) or 5-bromo-isatin (23) with 3,4-diamino-5-methyl-4H-1,2,4-triazole

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H. Al Rasheed, Hessa, Azizah M. Malebari, Kholood A. Dahlous, and Ayman El-Faham. "Synthesis and Characterization of New Series of 1,3-5-Triazine Hydrazone Derivatives with Promising Antiproliferative Activity." Molecules 25, no. 11 (2020): 2708. http://dx.doi.org/10.3390/molecules25112708.

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A new series of s-triazine hydrazone derivatives was prepared based on the reaction of 6-hydrazino-2,4-disubstituted-s-triazine with p-substituted benzaldehyde derivatives using a straightforward synthetic pathway. The antiproliferative activity of all synthesized compounds was evaluated against two human cancer cell lines; breast cancer MCF-7 and colon carcinoma HCT-116 using MTT assay. Among all, 11 compounds have shown strong to moderate antiproliferative activity with IC50 values in the range 1.01–18.20 µM in MCF-7 and 0.97–19.51 µM in HCT-116. The best results were obtained with 4,4’-(6-(

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35

Paronikyan, Ervand G., Anthi Petrou, Maria Fesatidou, et al. "Derivatives of a new heterocyclic system – pyrano[3,4-c][1,2,4]triazolo[4,3-a]pyridines: synthesis, docking analysis and neurotropic activity." MedChemComm 10, no. 8 (2019): 1399–411. http://dx.doi.org/10.1039/c9md00187e.

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8-Hydrazino derivatives of pyrano[3,4-c]pyridines and derivatives of new heterocyclic system 3-thioxopyrano[3,4-c][1,2,4]triazolo[4,3-a]pyridines were synthesized and evaluated for their neurotropic activity. The most active compound in all tests appeared to be 5g.

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36

Gad, Emad M., Mohamed S. Nafie, Elsayed H. Eltamany, Magdy S. A. G. Hammad, Assem Barakat, and Ahmed T. A. Boraei. "Discovery of New Apoptosis-Inducing Agents for Breast Cancer Based on Ethyl 2-Amino-4,5,6,7-Tetra Hydrobenzo[b]Thiophene-3-Carboxylate: Synthesis, In Vitro, and In Vivo Activity Evaluation." Molecules 25, no. 11 (2020): 2523. http://dx.doi.org/10.3390/molecules25112523.

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A multicomponent synthesis was empolyed for the synthesis of ethyl 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate 1. An interesting cyclization was obtained when the amino-ester 1 reacted with ethyl isothiocyanate to give the benzo[4,5]thieno[2,3-d][1,3]thiazin-4-one 3. Acylation of the amino-ester 1 with chloroacetyl chloride in DCM and Et3N afforded the acylated ester 4. The amino-ester 1 was cyclized to benzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one 8, which was reacted with some alkylating agents leading to alkylation at nitrogen 9–13. Hydrazide 14 was utilized as a synthon for the

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37

Tsyganova, Anna V., Artem O. Petrov, Alexey V. Shastin, et al. "Synthesis, Antibacterial Activity, and Cytotoxicity of Azido-Propargyloxy 1,3,5-Triazine Derivatives and Hyperbranched Polymers." Chemistry 6, no. 1 (2023): 1–12. http://dx.doi.org/10.3390/chemistry6010001.

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A new method for the synthesis of azido-propargyloxy derivatives of 1,3,5-triazine has been developed utilizing the nitrosation of hydrazyno-1,3,5-triazines. New hydrazines (2-hydrazino-4,6-bis(propargyloxy)-1,3,5-triazine and 2,4-dihydrazino-6-propargyloxy-1,3,5-triazine) were synthesized and characterized via FTIR, NMR spectroscopy and elemental analysis. The hyperbranched polymers with azide (diazide monomer) and propargyloxy terminal groups were obtained via the azide-alkyne polycycloaddition reaction of diazide and monoazide AB2-type monomers. The antibacterial activity against Escherichi

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38

Journal, Baghdad Science. "Synthesis of New Heterocyclic Derivatives from 4-(3, 5-Dimethyl-1-phenyl-1H-pyrazol-4-ylazo)- benzoic acid." Baghdad Science Journal 7, no. 1 (2010): 727–36. http://dx.doi.org/10.21123/bsj.7.1.727-736.

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In this work pyrazolin derivatives were prepared from the diazonium chloride salt of 4-aminobenzoic acid. Azo compounds were prepared from the reaction of an ethanolic solution of sodium acetate and calculated amount of active methylene compound namely, acetyl acetone to obtain the corresponding hydrazono derivative (1). Cyclocondensation reaction of compounds (1) with hydrazine hydrate and phenyl hydrazine in boiling ethanol affording the corresponding pyrazoline-5-one derivatives of 4-aminobenzoic acid (2,3). Then compound (3) was reacted with thionyl chloride to give the corresponding acid

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39

Chaudhari, J. A., M. V. Hathi, and R. P. Patel. "Studies on Novel Bisaryl hydrazino-s-triazine Derivatives." E-Journal of Chemistry 3, no. 4 (2006): 298–302. http://dx.doi.org/10.1155/2006/958696.

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Various 2-phenyloxy-4,6-bisarylhydrazino-1,3,5-triazines(3a-f) were prepared by reaction of 2- phenyloxy -4,6-dichloro -1,3,5-triazine and various aryl hydrazine derivatives. All the 3a-f derivatives were characterized by elemental analysis and IR spectral studies. All the compounds were screened for microbial activity against gram-positive and gram-negative bacteria.

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Alavijeh, Nahid S., Reza Zadmard, Sorour Ramezanpour, Saeed Balalaie, Mohammad S. Alavijeh та Frank Rominger. "Efficient synthesis of lower rim α-hydrazino tetrazolocalix[4]arenes via an Ugi-azide multicomponent reaction". New Journal of Chemistry 39, № 8 (2015): 6578–84. http://dx.doi.org/10.1039/c5nj00845j.

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Abdelmohsen, Shawkat A., and Talaat I. El Emary. "SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL ACTIVITY OF NOVEL PYRAZOLO[3,4-b]PYRIDINES AND THEIR SPIRO-HETEROCYCLIC DERIVATIVES." JOURNAL OF ADVANCES IN CHEMISTRY 10, no. 7 (2014): 2901–15. http://dx.doi.org/10.24297/jac.v10i7.6802.

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The present work describes the synthesis of a novel series of heterocyclic moieties derived from 5-acetylpyrazolo[3,4-b]pyridine (1). The formation of chalcones (2a-d) was utilized to synthesize pyrazoline, isoxazoline and pyrimidine derivatives (3-10). Thiosemicarbazone and semicarbazone (11, 17) were utilized to synthesize other new triazolethiones, thiadiazole and selenadiazole derivatives (11-19). Some new spiro derivatives (22-25) were synthesized by the reaction of chalcone (21) of 1 and isatine with hydrazines, hydroxyl amines and thiourea. Also, The reaction of 1 with cyanoacetyl hydra

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42

M., A. El-Sekily, H. Mancy S., and Kh. El-Sekely M. "Synthesis and characterisation of triazolo- and pyrazol-3-yl quinoxaline derivatives from dehydro-L-ascorbic acid hydrazone and their antimicrobial activity." Journal of India Chemical Society Vol. 95, Jun 2018 (2018): 641–49. https://doi.org/10.5281/zenodo.5642875.

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Department of Chemistry, Faculty of Science, University of Alexandria, Ibrahimia, P.O.Box 426, 21321 Alexandria, Egypt E-mail: prof_dr_m_a_elsekily@yahoo.com Department of Physics and Chemistry, Faculty of Education, University of Alexandria, El-Chatby, Alexandria, Egypt Department of Chemistry, Faculty of Science, Alexandria University, Egypt <em>Manuscript received 08 February 2018, revised 14 February 2018, accepted 29 May 2018</em> The 4-(pyrazol-3-yl)[1,2,4]triazolo[4,3-a]quinoxaline derivatives 4a-c were prepared by the reaction of 2-chloro-3-[5- (acetoxymethyl)-1-phenylpyrazol-3-yl]quin

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43

M., B. Deshmukh, and Patil Suresh. "Synthesis of new N3-substituted quinazolin-4(3H)one derivatives." Journal of Indian Chemical Society Vol. 83, Apr 2006 (2006): 393–96. https://doi.org/10.5281/zenodo.5836850.

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Department of Chemistry, Shivaji University, Kolhapur-4Jf, U04, Maharashtra. India Padmabuhshan Dr. Vasantraodada Patil Mahavidyalaya, Tasgaon, Sangli-416 311, Maharashtra, India E-mail: m_deshmukhl@rediffmail.com <em>Manuscript received 20 June 2005, revised 16 December 2005, accepted 22 December 2005</em> Quinazolin-4-one (1) was synthesized by reacting anthranilic acid with excess of formamide, which was N-alkylated with chloroncetone to form quinazolin-4-one-3-yl propan-2-one (2). The interaction of 2 with phenylhydrazine, 2,4-dinitropheny lhydrazine and semicarbazide gave the correspondin

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44

Suaad Mohammed Hussain and Zainab Abdul Zahraa. "Synthesis, characterization and antimicrobial activity of some new N-substituted-oxindole derivatives." Journal of Wasit for Science and Medicine 8, no. 3 (2022): 89–99. http://dx.doi.org/10.31185/jwsm.274.

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The aim of this research is the synthesis of new heterocyclic derivatives containing 4-oxo-thiazolidines, tetrazol or oxoazetidin ring from oxindole. To obtain these derivatives, oxindole [1] was chosen as the starting material to synthesize -chloro-N-oxindole acetamide [2] which was prepared by two methods. The first method by direct condensation of oxindole with chloroacetylchloride in presence of triethylamine and absolute ethanol as solvent. The second method by reaction of chloroacetylchloride with sodium salt of oxindole. Treatment of -chloro-N-oxindole acetamide [2] with hydrazine hyd

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45

Attaby, Fawzy A., and Sanaa M. Eldin. "Synthesis of Pyrimidine, Thiazolopyrimidine, Pyrimidotriazine and Triazolopyrimidine Derivatives and their Biological Evaluation." Zeitschrift für Naturforschung B 54, no. 6 (1999): 788–98. http://dx.doi.org/10.1515/znb-1999-0614.

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Pyrimidin-4-one-2-thione (3) was synthesized via the reaction of thiourea (1) with ethyl benzoylacetate (2) and was taken as a starting material for the present study via its reactions with the halogen-containing reagents 6a-d and lOa-c to give the corresponding thiazolopyrimidines 8, 9 and 12a-c. The 2-hydrazino derivatives 5 were synthesized either via the reaction of 3 or 4 with hydrazine hydrate. Compound 5 reacted with 6a-c and lOa-c to give the corresponding pyrimidotriazines 17a-c and 19 respectively. Also, compound 5 reacted with the active methylene-containing reagents 13 and 2a,b to

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46

Thanki, Pragna H., Dhaval V. Hingrajiya, Jayesh J. Modha, and Jalpa H. Vadgama. "Synthesis, characterization and antibiotic evaluation of various biologically active derivatives of 4-Alkylpyrimidine-5-carbonitrile." Current Chemistry Letters 12, no. 3 (2023): 537–44. http://dx.doi.org/10.5267/j.ccl.2023.3.002.

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Extensive research work has been published on Tetrahydro and Dihydropyrimidine derivatives. Pyrimidine-5-Carbonitrile and its analogs have demonstrated a large number of activities. Some 6-Halogenosubstituted pyrimidine analogs have also been reported to be biologically active to a certain extent, but the literature survey reveals not much report on 6-alkylated pyrimidine derivatives. Targeting enhancement in biologically useful properties of a lead molecule through the association of it with active pharmacophoric groups or molecules is a conventional method in pharmaceutical research. With an

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47

Alagarsamy, Veerachamy, Viswas Solomon, G. Krishnamoorthy, M. T. Sulthana, and B. Narendar. "Synthesis and antimicrobial activities of 1-(3-benzyl-4-oxo-3H-quinazolin-2-yl)-4-(substituted)thiosemicarbazide derivatives." Journal of the Serbian Chemical Society 80, no. 12 (2015): 1471–79. http://dx.doi.org/10.2298/jsc150103053a.

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A series of 1-(3-benzyl-4-oxo-3H-quinazolin-2-yl)-4-(substituted) thiosemicarbazides (AS1-AS10) were obtained by the reaction of 2-hydrazino- 3-benzyl quinazolin-4(3H)-one (6) with different dithiocarbamic acid methyl ester derivatives. The key intermediate 3-benzyl-2-thioxo-2,3-dihydro-1Hquinazolin-4-one (4) was obtained by reacting benzyl amine (1) with carbon disulphide and sodium hydroxide in dimethyl sulphoxide to give sodium dithiocarbamate, which was methylated with dimethyl sulfate to yield the dithiocarbamic acid methyl ester (2) and condensed with methyl anthranilate (3) in ethanol y

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48

Song, Wenlin, Shiliang Li, Yi Tong, et al. "Structure-based design of potent human dihydroorotate dehydrogenase inhibitors as anticancer agents." MedChemComm 7, no. 7 (2016): 1441–48. http://dx.doi.org/10.1039/c6md00179c.

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A series of hydrazino-thiazole derivatives were synthesized, of which compound 22 was the most potent inhibitor of hDHODH (IC<sub>50</sub> = 1.8 nM). Furthermore, 22 exhibited better antiproliferative activity than brequinar in cancer cell lines.

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49

Kumbhar, Navanath, Neelofar Khan, Rohit Bavi, Sagar Barage, and Ayesha Khan. "Reversal of P-glycoprotein Mediated Multidrug Resistance in MCF-7/R Cancer Cells by Esculetin Derivatives: Experimental and MD Simulation Studies." American Journal of Biomedical and Life Sciences 12, no. 3 (2024): 30–48. http://dx.doi.org/10.11648/j.ajbls.20241203.12.

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Coumarins of natural origin have been explored as potential inhibitors of P-glycoprotein (P-gp). Esculetin which belongs to the class of coumarin has been derivatized with known hydrazine pharmacophores viz; benzoyl hydrazine (BH), isonicotinyl hydrazine (INH), and hydrazino benzoic acid. The homology modeling approach was used to predict the three-dimensional structure of human P-gp. An &lt;i&gt;in-silico&lt;/i&gt; study has been performed for the structural insight into the molecular mechanism of P-gp inhibition of the esculetin derivatives by molecular docking (MD) and simul

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50

El Ashry, El Sayed H., Laila Fathy Awad, and Omayma Kh Bdeewy. "Synthesis of tetrahydroindazol-4(5H)one and 7-thione from reaction of functionalized cyclic enaminones with hydrazine." Mediterranean Journal of Chemistry 7, no. 6 (2019): 463–71. http://dx.doi.org/10.13171/mjc761901713eshea.

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Functionalized enaminones; 3-N-(aryl)amino-1--oxo-cyclohex-2-ene-2-dithiocarboxylates cyclohex-2-en-1-ones and 3-N-(aryl)amino-2-(N-aryl)thioamido-cyclohex-2-en-1-ones were obtained upon reaction of 3-N(aryl)amino-5,5-dimethyl-1-oxo-cyclohex-2-enes with carbon disulfide in presence of sodium hydroxide in DMSO, followed by methylation with dimethyl sulfate or with phenyl and p-bromophenyl isothiocyanates in toluene or under solvent-free condition, respectively. The cyclization of the dithioesters or the thioamides with hydrazine hydrate was accompanied by a displacement of the 3-N- arylamine mo

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