Relevant bibliographies by topics / Hydrazone

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'Hydrazone'

Author: Grafiati
Published: 4 June 2021
Last updated: 26 January 2023

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Journal articles on the topic "Hydrazone"

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Kaur, Aneet Kamal, Renu Bala, Poonam Kumari, Sumit Sood, and Karan Singh. "Microwave Assisted Vilsmeier-Haack Reaction on Substituted Cyclohexanone Hydrazones: Synthesis of Novel 4,5,6,7-Tetrahydroindazole Derivatives." Letters in Organic Chemistry 16, no. 3 (February 11, 2019): 170–75. http://dx.doi.org/10.2174/1570178615666180917101637.

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Vilsmeier-Haack reaction is one of the most important chemical reactions used for formylation of electron-rich arens. Even though Vilsmeier-Haack reaction was studied on a wide variety of hydrazones of enolizable ketones, literature lacks the examples of the use of 4-substituted cyclohexanones as a substrate. The cyclization potential of hydrazones of cyclic keto compounds is still interested topic of investigation. In the present study, the reaction of various hydrazines with 4-substituted cyclohexanones was proceeded and the resulted hydrazones in crude form were treated with Vilsmeier- Haack reagent using both conventional as well as microwave methods. The reaction of phenyl hydrazine with 4-phenylcyclohexanone yielded the corresponding tetrahydro-1H-carbazole instead of hydrazone during solvent evaporation at 40ºC. By keeping the temperature of water bath to 0ºC, the corresponding hydrazone was isolated in crude form which was immediate treated with POCl3/DMF for 10 min at 90ºC using microwave irradiation method afforded novel 4,5,6,7-tetrahydroindazole derivative. Using this optimized condition, the substrate scope for the synthesis of tetrahydroindazole derivatives was explored and synthesized total 6 final compounds. The microwave assisted synthesis of tetrahydroindazoles from 4-substituted cyclohexanones has been reported for the first time under mild conditions in good yield. Easy work up procedure, high yielding, shortened reaction times, clean and ecofriendly are the main advantages of this protocol.
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Popiołek, Łukasz. "Updated Information on Antimicrobial Activity of Hydrazide–Hydrazones." International Journal of Molecular Sciences 22, no. 17 (August 30, 2021): 9389. http://dx.doi.org/10.3390/ijms22179389.

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Hydrazide–hydrazones possess a wide spectrum of bioactivity, including antibacterial, antitubercular, antifungal, anticancer, anti-inflammatory, anticonvulsant, antidepressant, antiviral, and antiprotozoal properties. This review is focused on the latest scientific reports regarding antibacterial, antimycobacterial, and antifungal activities of hydrazide–hydrazones published between 2017 and 2021. The molecules and their chemical structures presented in this article are the most active derivatives, with discussed activities having a hydrazide–hydrazone moiety as the main scaffold or as a side chain. Presented information constitute a concise summary, which may be used as a practical guide for further design of new molecules with antimicrobial activity.
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Al-Shiekh, Mariam A., Hanady Y. Medrassi, Mohamed H. Elnagdi, and Ebtisam A. Hafez. "Substituted Hydrazonals as Building Blocks in Heterocyclic Synthesis: A New Route to Arylhydrazonocinnolines." Journal of Chemical Research 2007, no. 7 (July 2007): 432–36. http://dx.doi.org/10.3184/030823407x234617.

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2-heteroylhydrazonopropanals 2a–e and 3-oxo-2-arylhydrazonopropanals 2f–k were prepared via coupling of enaminones 1 with aromatic diazonium salts. Compounds 2a–c condensed with hydrazine hydrate to yield the corresponding hydrazones 3a–c which afford on cyclisation the cinnoline derivatives 6a–c, while condensation of 2g, j with hydrazine hydrate directly yielded the pyrazole derivatives 4g–j. Condensation of 2a–c, f, g with phenyl hydrazine gave the corresponding phenyl hydrazone derivatives 7a–c, f, g. Structures of 2a, h and 3a were assessed by single crystal X-ray analyses.
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Edrees, Mastoura M. "Synthesis of 4-hydrazinopyrazolo[3,4-d]pyrimidines and their Reactions with Carbonyl Compounds." Journal of Chemical Research 37, no. 1 (January 2013): 6–10. http://dx.doi.org/10.3184/174751912x13543818811749.

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Synthesis of a new 4-hydrazinopyrazolo[3,4- d]pyrimidine was achieved via heating (4,6-dithioxo-1 H-pyrazolo[3,4- d] pyrimidin-3-yl)acetonitrile with hydrazine hydrate. Reactions of the latter product with thiophene-2-carbaldehyde and ethyl hydrazonoacetoacetate analogues afforded the corresponding hydrazone and pyrazole derivatives, respectively. Similarly, condensation of 2-[6-(benzylsulfanyl)-4-hydrazino-1 H-pyrazolo[3,4- d]pyrimidin-3-yl]acetonitrile with thiophene-2-carbaldehyde and ethyl hydrazonoacetoacetate analogues gave the respective hydrazone and pyrazolone derivatives. Alkylation reactions of 2-[4,6-bis(benzylsulfanyl)-1 H-pyrazolo[3,4- d]pyrimidin-3-yl]acetonitrile with arylamines gave the respective 4-( N-arylamino)-6-benzylsulfanylpyrazolo[3,4- d]pyrimidine derivatives.
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Pogonin, Aleksandr E., George A. Gamov, Maksim N. Zavalishin, and Valentin A. Sharnin. "CONFORMATIONAL BEHAVIOR OF HYDRAZONE DERIVED FROM PYRIDOXAL 5’-PHOSPHATE AND ISONIAZID." IZVESTIYA VYSSHIKH UCHEBNYKH ZAVEDENIY KHIMIYA KHIMICHESKAYA TEKHNOLOGIYA 61, no. 12 (December 12, 2018): 101–7. http://dx.doi.org/10.6060/ivkkt.20186112.5846.

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The hydrazones derived from pyridoxal or pyridoxal 5’-phosphate and heterocyclic hydrazides are of interest due to their potential biological activity and metal sensing properties. These characteristics of hydrazones could be dependent on the conformation equilibria of molecule since the most stable conformer could differ from the one with the highest affinity towards biomolecule or metal ion. In the present contribution, deprotonated hydrazone formed by pyridoxal 5’-phosphate and isoniazid (PLP-INH3-) was studied by means of quantum chemistry. Three rotations leading to eight conformers are possible for this hydrazone; however, four of those species obtained by rotation of pyridine ring of isoniazid residue are degenerated. The geometry of different non-degenerated rotation conformers of the hydrazine (differing by the mutual arrangement of carbonyl group of the isoniazid residue and oxygen in 3’-site of PLP moiety) was optimized using density functional theory (B3LYP/6-311++G(d,p)). Activation barriers were evaluated. Changes in energy and geometry of conformers as well as transition states are discussed. Quantitative QTAIM (Quantum Theory of Atoms in Molecules) analysis was performed in order to check the intermolecular hydrogen bonding existence. The species capable of forming the complex with the metal ions differs from the most stable (according to the total energy values) conformer. The preliminary prediction of biological activity of PLP-INH3- hydrazone and the docking for the hydrazone and G-protein-coupled receptor kinase were performed and the preferable conformation for ligand binding to the kinase active site was found.
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Alheety, Nuaman. "Synthesis, Characterization and Antimicrobial Activity Study of Some New Substituted Benzoxazole Derivatives." Baghdad Science Journal 16, no. 3 (September 1, 2019): 616. http://dx.doi.org/10.21123/bsj.2019.16.3.616.

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This research included the preparation of 2-mercaptobenzoxazole (N1) by the reaction of ortho-aminophenol with carbon disulfide in an alcoholic potassium hydroxide solution. The 2-mercapto benzoxazole (N1) was then treated with hydrazine to obtain the 2-hydrazino benzoxazole (N2). A number of hydrazones (N3-N5) were prepared through the reaction of N2 with different benzaldehydes. The compound (N6) was also prepared whereby the ring closing of hydrazone (N3) using chloroacetylchloride, while the compound (N7) was prepared by treating 2-hydrazino benzoxazole with acetylacetone. When the compound (N1) was treated with formaldehyde, it afforded the compound (N8). Also, the N9 was obtained from the reaction of N1 with chloroacetic acid in the presence of alcoholic potassium hydroxide. The prepared compounds were characterized using physico-chemical and spectroscopic methods such as melting point, infrared spectroscopy (IR) and the proton nuclear magnetic resonance (1H-NMR). Thereafter, some of the compounds were selected for in vitro antibacterial activity and one of these compounds showed an inhibition effect against gram positive only which is very important because it is considered as specific antibacterial drug.
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Groziak, Michael P., and Paul D. Robinson. "The Structural Basis for Hydrolysis Resistance in the Esters of (2-Formylphenyl)boronic Acid 2,4-Dinitrophenylhydrazones." Collection of Czechoslovak Chemical Communications 67, no. 7 (2002): 1084–94. http://dx.doi.org/10.1135/cccc20021084.

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Under conditions that typically afford bicyclic boron heterocycles directly, (2-formylphenyl)boronic acids react with 2,4-dinitrophenylhydrazine in ethanol to give highly waterresistant diethyl boronate esters. Two such 2,4-dinitrophenylhydrazones were prepared and their X-ray crystal structures determined. Contrary to a previous suggestion that their unusual stability is due to an intramolecular N→B coordination giving a six-membered BN2C3 ring system based on a (Z)-hydrazone, these compounds instead were found to be (E)-hydrazones internally stabilized by a weak intramolecular interaction between nitrogen and boron from within a five-membered ring. Further study revealed that the electron deficiency of the starting hydrazine reagent plays a key role in determining the structure of the hydrazone isolated, and that the water-resistant boronate esters can be hydrolyzed under forcing conditions to the boronic acids.
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Ünver, Hakan, Burak Berber, Rasime Demirel, and Ayşe T. Koparal. "Design, Synthesis, Anti-Proliferative, Anti-microbial, Anti-Angiogenic Activity and In Silico Analysis of Novel Hydrazone Derivatives." Anti-Cancer Agents in Medicinal Chemistry 19, no. 13 (December 11, 2019): 1658–69. http://dx.doi.org/10.2174/1871520619666190318125824.

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Background: Cancer is the second leading cause of death globally. Hydrazone and hydrazone derivatives have high activity, and for this reason, these compound are greatly used by researchers to synthesize new anti-cancer drug. The aim of this research work is to synthesize novel anticancer agents. Methods: New hydrazone derivatives were synthesized via a reaction between 3-formylphenyl methyl carbonate and benzhydrazide, 4-methylbenzoic hydrazide, 4-tert-butylbenzoic hydrazide, 4-nitrobenzoic hydrazide and 3- methoxybenzoic hydrazide, and were successfully characterized using elemental analysis, 1H-NMR, 13C-NMR, FT-IR and LC-MS techniques. The synthesized compounds were evaluated for their antimicrobial (some grampositive and -negative bacteria, filamentous fungi and yeasts), anti-proliferative (T47D and HCC1428-breast cancer cells) and anti-angiogenic (HUVEC-endothelial cells) activities. The anti-proliferative activities of the hydrazone compounds R1-R5 were studied on these cell lines by MTT assay. The anti-angiogenic potential of the compounds was determined by the endothelial tube formation assay. To identify structural features related to the anti-proliferative activity of these compounds, 2D-QSAR was performed. Results: The results indicated that compound R3 exhibited strong anti-angiogenic and anti-proliferative activity on breast cancer cell lines and healthy cell lines. Also, this compound; possessing a tertiary butyl moiety on the hydrazine, exhibited the highest inhibitory effect against all tested microorganisms; in particular, it inhibited Candida albicans at a lower concentration than ketoconazole. Among the investigated compounds, those bearing methyl, tertiary butyl (compound R2, R3) and methoxy (compound R5) moiety were found to be more successful anticandidal derivatives than standard antifungal antibiotics. The QSAR analysis suggested that the tumor specificity of the hydrazone correlated with their molecular weight, lipophilicity, molar refractivity, water solubility, DipolHybrid:(MOPAC) and ExchangeEnergy:(MOPAC). Absorption, Distribution, Metabolism and Elimination (ADME) analysis of the hydrazone compounds showed that they have favorable pharmacokinetic and drug-likeness properties. The ADME results clarify that R3 is the best compound in terms of pharmacokinetic properties. In contrast to other compounds; target prediction analysis of the compound R3 showed inhibitory activity on estrogen-related receptor alpha transcription factor (ESRRA). The target prediction analysis was supported by molinspiration bioactivity score. Conclusion: The R3 compound is considered to be an important candidate for future studies with its suitability for the Lipinski’s rule of five for drug-likeness, and effective in vitro and in silico results.
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Jasril, E. Juwiyatri, S. N. Fauza, and N. Afriana. "Synthesis, in vitro Antioxidant Activity, and Toxicity Evaluation of Hydrazone Derivatives Naphthalene-1-ylmethylene hydrazine." Journal of Physics: Conference Series 2049, no. 1 (October 1, 2021): 012050. http://dx.doi.org/10.1088/1742-6596/2049/1/012050.

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Abstract Hydrazone is a versatile organic compound that has a basic structure (-NHN=CH-) called the azomethine group. This structure is responsible for the physical and chemical of hydrazone, which makes this compound has variety bioactivities such as antioxidant, antitumor, and anticancer. In this work, two hydrazone derivatives from 1-naphthaldehyde and hydrazine (phenylhydrazine/hydrazine hydrate) have been synthesized under microwave irradiation. Their antioxidant activity and toxicity were evaluated by DPPH and BSLT method, respectively. Structures of the synthesized compounds were confirmed based on spectroscopic data included UV, FTIR, HRMS, and 1H-NMR. Based on the DPPH assay, hydrazone from phenylhydrazine has strong antioxidant (IC50 28.90 μg/mL) but inactive antioxidant for hydrazine hydrate (IC50 >1000 μg/mL). However, both compounds have a high toxicity effect on Artemia Salina Leach with each LC50 1.45 and 47.20 μg/mL, hence they have the potential to be developed into anticancer drugs.
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Wu, Shouting, Xi Liang, Fang Luo, Hua Liu, Lingyi Shen, Xianjiong Yang, Yali Huang, et al. "Synthesis, Crystal Structure and Bioactivity of Phenazine-1-carboxylic Acylhydrazone Derivatives." Molecules 26, no. 17 (September 1, 2021): 5320. http://dx.doi.org/10.3390/molecules26175320.

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A phenazine-1-carboxylic acid intermediate was synthesized from the reaction of aniline and 2-bromo-3-nitro-benzoic acid. It was then esterified and reacted with hydrazine hydrate to afford phenazine-1-carboxylic hydrazine. Finally, 10 new hydrazone compounds 3a–3j were obtained by the condensation reaction of phenazine-1-carboxylic acid hydrazide and the respective aldehyde-containing compound. The structures were characterized by 1H and 13C NMR spectroscopy, MS and single crystal X-ray diffraction. The antitumor activity of the target compounds in vitro (HeLa and A549) was determined by thiazolyl blue tetrazolium bromide. The results showed that compound (E)-N′-(2-hydroxy-4-(2-(piperidine-1-yl) ethoxy) benzyl) phenazine-1-carbonyl hydrazide 3d exhibited good cytotoxic activity.
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Dissertations / Theses on the topic "Hydrazone"

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Belkheiri, Nadji. "Dérivés phénoliques à activités antiathérogènes." Toulouse 3, 2010. http://thesesups.ups-tlse.fr/961/.

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Les maladies cardio-vasculaires (MCV) représentent la première cause de mortalité et de morbidité dans les pays industrialisés. Il a été clairement démontré que la peroxydation des lipoprotéines, essentiellement les lipoprotéines de faible densité (LDL), constitue une étape critique d'un processus très complexe aboutissant à l'athérosclérose. En effet, l'augmentation relative des espèces réactives de l'oxygène (ERO) due au stress oxydant, induit par le biais des lipoprotéines de basse densité oxydées (LDLox), un dysfonctionnement vasculaire. Les dérivés phénoliques sont connus pour leurs propriétés antioxydantes et plus particulièrement leurs propriétés piégeurs de radicaux libres. D'autre part, les hydrazones sont des piégeurs de carbonyles efficaces. Dans ce cadre, les travaux décrits dans ce manuscrit sont centrés sur la recherche de nouvelles molécules duales possédant des propriétés antioxydantes et cytoprotectrices vis-à-vis de l'action délétère des carbonyles issus de la peroxydation lipidiques des LDLs. Sur la base des résultats antérieurs du laboratoire, nous avons conçu et synthétisé un ensemble de dérivés phénoliques nouveaux issus d'une même brique moléculaire : la bisvanilline. Des bishydrazones symétriques et/ou disymétriques possédant dans ce cas une fonction vinyl-phosphonate et une fonction hydrazone ont été préparées et étudiées. Dans le même temps, les monohydrazones correspondantes issues du syringaldéhyde ont été synthétisées et testées. Dans un premier temps, les effets antioxydants et cytoprotecteurs ont été déterminés pour toutes les molécules synthétisées. Les composés les plus efficaces ont ensuite subi des tests complémentaires, pour évaluer leurs effets piégeurs de carbonyles, de radicaux NO° et O2-° dans des systèmes cellulaires (études in vitro). Les résultats obtenus montrent sans ambiguité que, pour la première fois, nous avons synthétisé des molécules possédant à la fois une activité antioxydante et un effet piégeur de carbonyle. Enfin, l'activité in vivo du composé le plus actif, a été évaluée. Dans un second temps, des études physicochimiques ont été menées afin de comprendre le mode d'action de ces composés à travers trois activités potentielles en liaison avec leurs propriétés antiathérogènes. Ces tests sont basés sont sur : -La capacité des composés synthétisés à piéger les radicaux stables DPPH• et ABTS•+. -Les propriétés complexantes des ces composés vis-à-vis du métal Cu. -L'action inhibitrice du composé le plus actif vis-à-vis de la production in vitro de l'anion superoxyde O2-°
Cardiovascular disease (CVD) are the leading cause of mortality and morbidity in industrialized countries. It has been clearly shown that peroxidation of lipoproteins, mainly low density lipoprotein (LDL), is a critical stage of a very complex process leading to atherosclerosis. Indeed, the relative increase of reactive oxygen species (ROS) due to oxidative stress, induced by means of oxidized low density lipoprotein (oxLDL), a vascular dysfunction. The phenolics are known for their antioxidant properties, especially their free radical scavengers. On the other hand, the hydrazones are effective scavengers carbonyls. In this context, the work described in this manuscript are focused on the research of new molecules with dual cytoprotective and antioxidant properties vis-à-vis the deleterious action of carbonyls from lipid peroxidation of LDL. Based on previous results of the laboratory, we designed and synthesized a new set of phenolics from the same brick molecular the bisvanilline. Bishydrazones of symmetrical and / or with dissymmetry in this case is a function of vinyl-phosphonate and function hydrazone were prepared and studied. At the same time, from the corresponding monohydrazones syringaldehyde have been synthesized and tested. Initially, the antioxidant and cytoprotective were determined for all the molecules synthesized. The most effective compounds were then tested further to assess the effects of carbonyl scavengers, radical O2°- and NO° cell systems (in vitro). The results show unambiguously that, for the first time, we have synthesized molecules with both antioxidant and carbonyl scavenger effect. Finally, the in vivo activity of the most active compound, was evaluated. In a second step, Physicochemical studies have been conducted to understand the mode of action of these compounds through three potential activities in conjunction with their antiatherogenic properties. These tests were on: -The ability of the compounds synthesized radical scavenging stable DPPH• and ABTS•+. -The complexing properties of these compounds with respect to the Cu metal. -The inhibitory action of the compound most active with respect to the in vitro production of superoxide anion O2- degrees
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Gellermann, Eike. "Silylhydrazine und -hydrazone Insertionsreaktionen und Isomerisierung /." [S.l. : s.n.], 1999. http://deposit.ddb.de/cgi-bin/dokserv?idn=963676393.

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Buff, Heiko. "Hydrazone als Aza-Enamine in der Nenitzescu-Reaktion." [S.l.] : [s.n.], 2001. http://deposit.ddb.de/cgi-bin/dokserv?idn=963417282.

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Klein, Jörg Martin. "Dynamic combinatorial chemistry of hydrazone and disulfide macrocycles." Thesis, University of Cambridge, 2011. https://www.repository.cam.ac.uk/handle/1810/252248.

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Cheaib, Khaled. "Synthesis, characterization and photochemical properties of 3d transition metal supported by aroyl-hydrazone ligands." Thesis, Strasbourg, 2013. http://www.theses.fr/2013STRAF062/document.

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Ce travail de thèse explorait certains aspects de la chimie de coordination de complexes moléculaires à bases de métaux 3d (Fe, Cu, Mn et Ni) supportés par des ligands azotés de type aroyle-hydrazone. Le travail de cette thèse était plus particulièrement centré sur le développement des nouveaux ligands et la photo chimie des complexes ferriques, afin d’élucider en particulier les mécanismes de la photo réduction qui valorise un brevet du laboratoire sur la production et le stockage d’énergie solaire via la photo réduction d’ions ferriques. Les complexes mis en jeu dans le processus ont été totalement caractérisés en solution et à l’état solide. Ce phénomène prend place en solution comme en solution gelée. La cinétique du processus photochimique a été suivie par UV-Visible comme par RPE. Cette photo réduction passe par un intermédiaire radicalaire et le solvant joue le rôle du donneur des électrons. Ce processus a été totalement étudié : l’effet du solvant, l’effet de la modification dans la sphère de coordination du complexe, l’effet de la modification de la périphérie des ligands et finalement l’effet des longueurs d’ondes. D’autres domaines sont également explorés, comme le magnétisme moléculaire ou encore la catalyse homogène (oligomérisation de l’éthylène) avec des complexes à base de Ni2+
This PhD thesis explored some aspects of the coordination chemistry of molecular complexes based on 3d transition metal ions (Fe, Cu, Mn and Ni) coordinated by multidentate aroyl-hydrazone ligands. The work of this thesis was particularly focused on the development of new ligands, their coordination chemistry and the photochemistry of ferric complexes. The central objective of this work was to elucidate the mechanism of the photo reduction process, in order to valorize an already accepted laboratory patent on the production and storage of solar energy. The complexes involved in the process have been fully characterized in solution and in the solid state. This phenomenon takes place in solution as in frozen solution. The kinetics of the photochemical process was followed by UV-Visible as by RPE. This photo reduction passes through a radical intermediate and the solvent plays the role of the electron donor. This process has been fully studied: the effect of the solvent, the effect of the modification in the coordination sphere of the complex, the effect of the modification of the periphery of the ligands and finally the effect of the light and different wavelengths. Other fields are also explored, such as molecular magnetism for different mono and dinuclear iron and manganese complexes or even homogeneous catalysis (oligomerization of ethylene) with complexes based on Ni(II)
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Köhler, Brigitte. "Von der Koordinationschemie der Azaphosphole zur Koordinationschemie funktionalisierter Hydrazone." Diss., lmu, 2009. http://nbn-resolving.de/urn:nbn:de:bvb:19-104523.

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Fischmann, Svenja [Verfasser]. "Makrocyclen durch dynamisch-kombinatorische Kondensationsreaktionen Imine - Hydrazone - Oxime / Svenja Fischmann." Kiel : Universitätsbibliothek Kiel, 2015. http://d-nb.info/1080170979/34.

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Marques, de Oliveira Paulo Filho. "Investigation of mechanochemical synthesis of condensed 1,4-diazines and pharmaceutically attractive hydrazones." Thesis, Ecole nationale des Mines d'Albi-Carmaux, 2015. http://www.theses.fr/2015EMAC0007/document.

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L'un des objectifs des industries chimique et pharmaceutique est de développer des procédés verts évitant ou réduisant l'utilisation de solvants. Mais ne pas utiliser de solvant nécessite souvent des catalyseurs métalliques ou autre, ce qui rend les purifications délicates, comme dans le cas des synthèses de chimie fine permettant l'obtention de principes actifs pharmaceutiques. C'est ainsi que la mécanochimie a émergé en tant que voie durable pour la synthèse chimique, y compris dans le cas des transformations moléculaires organiques sous contrainte mécanique. Malgré les progrès récents de cette méthodologie, certains aspects de l'action mécanique ne sont pas totalement élucidés, en particulier ce qui concerne les mécanismes. Dans cette thèse, trois axes principaux de la mécanochimie ont été explorés. Dans une première partie, le mécanisme moléculaire de la synthèse de deux types de 1,4-diazines, la dibenzo[a,c]phenazine (DBPZ) et la 2,3-diphenylquinoxaline (DPQ), a été investigué. La RMN 13C CP-MAS a permis de mettre en évidence des intermédiaires de cette synthèse, et des mesures calorimétriques ont révélé que deux réactions se poursuivaient après broyage. La possibilité d'une réaction concertée a également été prise en compte dans le cas de la dibenzo[a,c]phenazine. La seconde partie concerne la formation de la 2,3-diphenylquinoxaline. Les paramètres du procédé ont été étudiés, dans le cas d'un broyeur à bille vibrant. L'influence des matériaux de broyage, de la taille et de la masse des billes, la granulométrie des matières premières, ainsi que la température des media de broyage ont été étudiés, permettant de déterminer une énergie d'activation apparente (Ea). Le tracé des courbes selon Arrhenius et Eyring-Polanyi a montré des changement de Ea caractéristiques de modifications au niveau du mécanisme, attribuées à l'apparition d'un possible eutectique fondant au dessus de 30°C, induit mécaniquement. Après cette étude qui a permis la compréhension de certains points fondamentaux, et d'approfondir les procédés de ces réactions modèles, une troisième partie traite de l'application de la mécanochimie à la synthèse en phase solide d'hydrazones d'intérêt pharmaceutique, et à celle catalysée de dérivés de l'isoniazide obtenus par réaction d'aldéhydes et d'hydrazines. D'une manière générale, les durées de réaction sont plus faibles, et les rendements meilleurs, qu'avec les méthodes classiques. L'influence des réactivités électronique et des hydrazines à l'état solide a été discutée. Les essais biologiques ont démontré une activité avérée des dérivés de l'isoniazide dans l'inhibition de Mycobacterium tuberculosis. Les résultats présentés dans cette thèse englobent plusieurs aspects très complémentaires de la mécanochimie. L'approche fondamentale du mécanisme est d'un accès difficile, en raison de la complexité du système, mais des avancées ont été réalisées comme la mise en évidence d'intermédiaires à longue durée de vie. Les paramètres du procédé apportent une contribution à la compréhension du mécanisme mais aussi en vue du scaling-up. Enfin, la mécanosynthèse s'est révélée être une méthode de chimie verte particulièrement adaptée à la synthèse d'hydrazones d'intérêt pharmaceutique, pour le screening de nouvelles entités ou la synthèse durable de produits de grande pureté
One of the goals of pharmaceutical and chemical industries is the development of green processes that eliminates or reduces the use of solvents. However, avoiding solvents often requires the use of metal catalysts or others, that accelerates chemical reactions, but make the purifications difficult, especially in the case of fine chemical products, such as active pharmaceutical ingredients. The mechanochemistry has emerged as a sustainable way that enables chemical synthesis, including organic molecular transformations, using the mechanical energy. In spite of the recent advances of the methodology, some aspects of the mechanical action still remain to be fully elucidated, mainly concerning the mechanisms. In this thesis, three main axes of mechanochemistry were explored. First, the molecular mechanism of 1,4-diazine mechanosynthesis, mentioning dibenzo[a,c]phenazine (DBPZ) and 2,3-diphenylquinoxaline (DPQ), is investigated by using 13C CP-MAS NMR that reveals intermediate species for DBPZ, and by calorimetric measurements that show continuation of the reaction after grinding for both reactions. The possibility of a concerted mechanism is considered for dibenzo[a,c]phenazine case. The second focus is on 2,3-diphenylquinoxaline product formation. The process parameters for a vibratory ball mill were studied. Grinding material, size and mass of the balls, granulometry of the starting material were assessed, as well as the temperature of the milling media, providing apparent activation energy (Ea). Arrhenius and Eyring-Polanyi plots presented changes in Ea indicating changes in mechanism, which was attributed to a possible mechanically induced eutectic melting after 30°C. Finally, after understanding some fundamentals and processes for those model reactions, the mechanochemical route was successfully applied to solid-state synthesis of pharmaceutically attractive phenolic hydrazones and catalyzed isoniazid derivatives synthesis, by reacting solid aldehydes and hydrazines. In general, the products were obtained in shorter times and in higher yields compared to classical thermal route. The roles of electronic and solid-state reactivity of the hydrazines were discussed. Biological assays demonstrated the great activity of isoniazid derivatives in inhibiting Mycobacterium tuberculosis. The results presented here cover the mechanochemistry at different levels. The fundamental comprehension is still difficult to access due to the complexity of the system, but some advances could be made such as the detection of intermediate species with significant lifetime. The process parameters are equally important to deduce some mechanism, but also for scale up purposes. At last, the mechanosynthesis of hydrazones showed to be a greener route to produce pharmaceuticals, for high screening of new ones, as well as for the synthesis of others, with great purity and waste reduction
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9

Garland, Keira. "A Practical Approach to Semicarbazone and Hydrazone Derivatives via Imino-isocyanates." Thèse, Université d'Ottawa / University of Ottawa, 2014. http://hdl.handle.net/10393/30725.

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Isocyanates have a broad spectrum of uses and they are used in the production of many products including polyurethane polymers, coatings, adhesives, paints and foams. While isocyanates are widely studied and well represented in the literature, nitrogen substituted isocyanates are quite rare. Amino and imino-isocyanates are examples of nitrogen substituted isocyanates. Previous work within the group studied the reactivity of these intermediates in the alkene aminocarbonylation reaction, and used hydrazones and hydrazides as precursors of nitrogen substituted isocyanates. From there, a second reaction pathway was studied. This involved the reactivity of hydrazones with nucleophiles to develop a simple exchange reaction. In this work, the substitution reactivity involving imino-isocyanates will be presented. This will include the scope of nucleophiles and hydrazones as well as a discussion on the formation of the imino-isocyanates. This reactivity allows for the facile formation of a variety of hydrazones with the flexibility to start from common hydrazone precursors.
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Yasar, Fatma. "An acyl hydrazone based molecular walker and light driven molecular shuttles." Thesis, University of Manchester, 2017. https://www.research.manchester.ac.uk/portal/en/theses/an-acyl-hydrazone-based-molecular-walker-and-light-driven-molecular-shuttles(69c27c64-71b4-486b-abb4-3c6e06e37b41).html.

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The work described in this thesis is inspired by natural-occurring molecules that are used throughout biology to perform specific, highly-selective tasks. This thesis illustrates the design, synthesis and investigation of novel molecular devices based on acyl hydrazones for the synthesis of a small molecule walker and light-driven molecular shuttles. Chapter One outlines a general overview of the design and synthesis of molecular devices, including molecular walkers and molecular shuttles. Some of the most important examples of walking molecules (both natural and synthetic) are described in detail, along with a comprehensive introduction of molecular shuttles and their synthetic mimics. Examples of stimuli-responsive molecular shuttles that have been developed are highlighted throughout the chapter. Chapter Two describes the design and synthetic progress towards a molecular walker, as well as detailing the optimisation of the synthetic steps achieved thus far. In this chapter, most of the work presented is based on the design and optimisation of the synthesis of an acyl hydrazone-based molecular walker, which will be able to walk directionally and repetitively along its conjugate track when the conditions are changed. A novel acyl hydrazone pyridine moiety is introduced to the system to achieve a high directional bias during the walking process. First, the concept and basis of the design is explained and further, the synthesis of the walker system is discussed in detail. Chapter Three illustrates the synthesis and operation of 1- and 2- station [2]-rotaxanes which exhibit all the requirements for a light-driven molecular shuttle. The effect of a new photo switchable binding station, an acyl pyridyl hydrazone, on the shuttling process is investigated by comparing the positional distribution of the macrocycle between the acyl hydrazone station and the succinamide-ester station, while the acyl hydrazone undergoes photo- and thermal isomerisation. The successful synthesis of this molecular architecture is described along with its operation, demonstrating high positional integrity and efficiency during the shuttling process.
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Books on the topic "Hydrazone"

1

Schmidt, Eckart W. Hydrazine and its derivatives: Preparation, properties, applications. 2nd ed. New York: Wiley-Interscience, 2001.

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Hydrazines and cancer: A guidebook on the carcinogenic activities of hydrazines, related chemicals, and hydrazine-containing natural products. Amsterdam: Harwood Academic Publishers, 2000.

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Kagaku Busshitsu Hyōka Kenkyū Kikō and Shin Enerugī Sangyō Gijutsu Sōgō Kaihatsu Kikō (Japan), eds. Hidorajin: Hydrazine. Tōkyō-to Shibuya-ku: Seihin Hyōka Gijutsu Kiban Kikō Kagaku Busshitsu Hyōka Kenkyū Kikō, 2007.

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Patil, K. C., and Tanu Mimani Rattan, eds. Inorganic Hydrazine Derivatives. Chichester, United Kingdom: John Wiley & Sons, Ltd, 2014. http://dx.doi.org/10.1002/9781118693599.

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Suzuki, M. Decomposition of hydrazine by high frequency glow electrical discharges. Washington, DC: National Aeronautics and Space Administration, 1988.

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Canada, Canada Health. Hydrazine sulphate: An information package. Toronto: Health Canada, 1996.

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Yade, N. Treatment for hydrazine-containing waste water solution. Washington DC: National Aeronautics and Space Administration, 1986.

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Yade, N. Treatment for hydrazine-containing waste water solution. Washington DC: National Aeronautics and Space Administration, 1986.

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Yade, N. Treatment for hydrazine-containing waste water solution. Washington DC: National Aeronautics and Space Administration, 1986.

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Curran, Francis M. In-situ analysis of hydrazine decomposition products. [Washington, DC: National Aeronautics and Space Administration, 1987.

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Book chapters on the topic "Hydrazone"

1

Lazny, Ryszard. "Hydrazone Linker Units." In Linker Strategies in Solid-Phase Organic Synthesis, 303–15. Chichester, UK: John Wiley & Sons, Ltd, 2009. http://dx.doi.org/10.1002/9780470749043.ch10.

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Li, Jie Jack. "Japp-Klingemann hydrazone synthesis." In Name Reactions, 208. Berlin, Heidelberg: Springer Berlin Heidelberg, 2003. http://dx.doi.org/10.1007/978-3-662-05336-2_154.

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Li, Jie Jack. "Japp–Klingemann hydrazone synthesis." In Name Reactions, 331–32. Cham: Springer International Publishing, 2014. http://dx.doi.org/10.1007/978-3-319-03979-4_142.

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Li, Jie Jack. "Japp-Klingemann hydrazone synthesis." In Name Reactions, 184. Berlin, Heidelberg: Springer Berlin Heidelberg, 2002. http://dx.doi.org/10.1007/978-3-662-04835-1_144.

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Li, Jie Jack. "Japp–Klingemann hydrazone synthesis." In Name Reactions, 302–3. Berlin, Heidelberg: Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-642-01053-8_133.

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Buss, Joan L., Marcelo Hermes-Lima, and Prem Ponka. "Pyridoxal Isonicotinoyl hydrazone and its analogues." In Iron Chelation Therapy, 205–29. Boston, MA: Springer US, 2002. http://dx.doi.org/10.1007/978-1-4615-0593-8_11.

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Tang, Jinkui, and Peng Zhang. "Hydrazone-Based Lanthanide Single-Molecule Magnets." In Lanthanide Single Molecule Magnets, 167–93. Berlin, Heidelberg: Springer Berlin Heidelberg, 2015. http://dx.doi.org/10.1007/978-3-662-46999-6_5.

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Lane, J. D., C. J. Pickett, and D. R. Stanley. "From Hydrazine and Coordinated Hydrazines." In Inorganic Reactions and Methods, 116–17. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2007. http://dx.doi.org/10.1002/9780470145227.ch86.

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Melnyk, Oleg, Nathalie Ollivier, Christophe Olivier, Catherine Gouyette, Tam Huynh-Dinh, and Hélène Gras-Masse. "Synthesis of Oligodeoxynucleotide-Peptide Conjugates Using Hydrazone Chemical Ligation." In Peptides: The Wave of the Future, 109–10. Dordrecht: Springer Netherlands, 2001. http://dx.doi.org/10.1007/978-94-010-0464-0_48.

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Pardasani, R. T., and P. Pardasani. "Magnetic properties of cobalt(II) complex with heteroaroyl-hydrazone." In Magnetic Properties of Paramagnetic Compounds, 728–29. Berlin, Heidelberg: Springer Berlin Heidelberg, 2017. http://dx.doi.org/10.1007/978-3-662-53971-2_382.

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Conference papers on the topic "Hydrazone"

1

Antonijević, Marko, Žiko Milanović, Dušica Simijonović, Zoran Marković, and Snežana Marković S. Zoran. "ANTIOXIDATIVE POTENCY AND RADICAL SCAVENGING ACTIVITY OF SELECTED COUMARIN-HYBRIDS." In 1st INTERNATIONAL Conference on Chemo and BioInformatics. Institute for Information Technologies, University of Kragujevac,, 2021. http://dx.doi.org/10.46793/iccbi21.458a.

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In previous studies, it was found that coumarins with hydrazide moiety show good antioxidative potential, while similar coumarins with hydrazone moiety are good anticancer agents. In this paper, the antioxidative potency and radical scavenging activity of two coumarin hydrazone derivatives were investigated. For this purpose, density functional theory method M062X with 6-311G++(d,p) basis set was implemented. It was found that investigated compounds exhibit good antioxidative potency, with very similar BDE values regardless of the position involved. On the other hand, PA values show that a preferable functional group for proton loss depends on the position of the OH group. In ortho position, OH group shows lower antioxidative potency than NH group, while in the same time in para position OH group is favourable position for antioxidative activity reactions. A similar situation is obtained by investigation of radical scavenging mechanisms, with the more pronounced difference in BDE between the positions in favour of the NH group. While SPLET is the most probable mechanism which is in competition with HAT in some cases (hydroxy radical) SET-PT was found to be a non-operative mechanistic pathway.
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Bruckdorfer, Thomas, Pavel S. Chelushkin, Ksenia V. Polyanichko, Maria Leko, Marina Dorosh, and Sergey V. Burov. "Convenient method of peptide hydrazide synthesis using a new hydrazone resin." In 35th European Peptide Symposium. Prompt Scientific Publishing, 2018. http://dx.doi.org/10.17952/35eps.2018.084.

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Branković, Jovica, Vesna Milovanović, and Vladimir P. Petrović. "CYCLOOXYGENASE-2 AS „IN SILICO“ TARGET OF PHENOLIC HYDRAZONE- TYPE DERIVATIVES." In 1st INTERNATIONAL Conference on Chemo and BioInformatics. Institute for Information Technologies, University of Kragujevac, 2021. http://dx.doi.org/10.46793/iccbi21.324b.

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In the present work, a series of phenolic hydrazone analogs were investigated in silico for their potential inhibitory activity toward COX-2. These examinations were based on the capability of hydrazone-based compounds to interact with numerous enzymes, as well as on their versatile biological features and therapeutical applications. COX-2 was selected due to its involvement in the inflammation and carcinogenesis processes. Regarding this, COX-2 represents a valid target for the development of compounds that could block the formation of harmful inflammation mediators.
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Meier, U., M. S. Wong, F. Pan, C. Bosshard, and P. Gunter. "Five-Mernbered Heteroaromatic Hydrazone Derivatives for Second-Order Nonlinear Optics." In Proceedings of European Meeting on Lasers and Electro-Optics. IEEE, 1996. http://dx.doi.org/10.1109/cleoe.1996.562188.

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Markava, Elga, Daina Gustina, and Inta Muzikante. "Optically induced azo-hydrazone tautomerism of some 2,6-dialkylphenol-based azobenzenes." In Advanced Optical Materials and Devices, edited by Steponas P. Asmontas and Jonas Gradauskas. SPIE, 2001. http://dx.doi.org/10.1117/12.425487.

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Carballido Piñeiro, Rocío, Ana María González Noya, Marcelino Maneiro, Laura Rodríguez Silva, and Rosa Pedrido. "Study of the conformational rearrangement of a tetradentate hydrazone ligand." In The 20th International Electronic Conference on Synthetic Organic Chemistry. Basel, Switzerland: MDPI, 2016. http://dx.doi.org/10.3390/ecsoc-20-d001.

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Zhang, Kui, Jingsong Wei, Zhimin Chen, Tao Wei, Yongyou Geng, Yang Wang, and Yiqun Wu. "Super resolution nano-information recording in a new hydrazone metal complex material." In 2016 International Workshop on Information Data Storage and Tenth International Symposium on Optical Storage, edited by Fuxi Gan and Zhitang Song. SPIE, 2016. http://dx.doi.org/10.1117/12.2248354.

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Sousa, Rui P. C. L., Susana P. G. Costa, Rita B. Figueira, and M. Manuela M. Raposo. "Quinoline-Based Hydrazone Derivative as a Biocide Chemosensor: Synthesis and Sensing Studies." In ECSA-9. Basel Switzerland: MDPI, 2022. http://dx.doi.org/10.3390/ecsa-9-13199.

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Scott, J. Campbell, Andrew Skumanich, M. D. Shattuck, and Hai Nguyen. "Comparison of the electrophotographic properties of a family of hydrazone charge-transport molecules." In SC - DL tentative, edited by Joseph Gaynor. SPIE, 1990. http://dx.doi.org/10.1117/12.19815.

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Kanchanadevi, S., S. Parveen, and V. Mahalingam. "Synthesis, characterization, crystal structure and DNA-binding studies of transition metal hydrazone complexes." In 9TH NATIONAL CONFERENCE ON THERMOPHYSICAL PROPERTIES (NCTP-2017). Author(s), 2018. http://dx.doi.org/10.1063/1.5031734.

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Reports on the topic "Hydrazone"

1

Garcia, B., and D. Chavez. Shock compression of liquid hydrazine. Office of Scientific and Technical Information (OSTI), January 1995. http://dx.doi.org/10.2172/105881.

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Karraker, D. G. The Oxidation of Hydrazine by Nitric Acid. Office of Scientific and Technical Information (OSTI), July 2001. http://dx.doi.org/10.2172/784248.

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Thiem, Terry L., Jason Brown, Johnathan Kiel, Eric Holwitt, and Gerald J. O'Brien. The Chemical and Biochemical Degradation of Hydrazine. Fort Belvoir, VA: Defense Technical Information Center, January 1997. http://dx.doi.org/10.21236/ada333221.

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Karraker, D. G. Cu(II) - Catalyzed Hydrazine Reduction of Ferrous Nitrate. Office of Scientific and Technical Information (OSTI), October 2001. http://dx.doi.org/10.2172/787806.

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HARDING LAWSON ASSOCIATES NOVATO CA. Hydrazine Blending and Storage Facility, Interim Response Action. Fort Belvoir, VA: Defense Technical Information Center, January 1991. http://dx.doi.org/10.21236/ada273439.

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Karraker, D. G. The Iron-Catalyzed Oxidation of Hydrazine by Nitric Acid. Office of Scientific and Technical Information (OSTI), July 2001. http://dx.doi.org/10.2172/783929.

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Zube, Dieter M., and Dan Fye. Low Bus Voltage Hydrazine Arcjet System for Geostationary Satellites. Fort Belvoir, VA: Defense Technical Information Center, July 1998. http://dx.doi.org/10.21236/ada408186.

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DeLorenzo, Robert J. The Effects of Hydrazines on Neuronal Excitability. Fort Belvoir, VA: Defense Technical Information Center, October 1993. http://dx.doi.org/10.21236/ada290120.

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Bertrand, Guy. Ammonia and hydrazine. Transition-metal-catalyzed hydroamination and metal-free catalyzed functionalization. Office of Scientific and Technical Information (OSTI), June 2012. http://dx.doi.org/10.2172/1253630.

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HARDING LAWSON ASSOCIATES NOVATO CA. Hydrazine Blending and Storage Facility, Interim Response Action Implementation. Final Safety Plan. Fort Belvoir, VA: Defense Technical Information Center, August 1989. http://dx.doi.org/10.21236/ada271897.

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