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Journal articles on the topic 'Hydrazone derivatives'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

Ekram Abdullah Basheer, Kalid Matny Al-jaanaby, and Feras Shauki Al-joboury. "Synthesis a Number of Heterocyclic Compounds Derived From Levofloxacin." Tikrit Journal of Pure Science 20, no. 5 (2023): 84–95. http://dx.doi.org/10.25130/tjps.v20i5.1244.

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In this paper, the preparation a number of heterocyclic compounds five membered rings like oxadiazole, imidazolidine, thiozolidine, tetrazole, azetidine 2-on. Hydrazide (1) was synthesized from the reaction of levofloxacin with hydrazine hydrate. Hydrazone compounds (2-9) were synthesized from the reaction (1) with a number of aldehydes, and 3-acetyl-1,3,4-oxadiazol (10-17) was prepared from the reaction of hydrazones (2-9) with acetic anhydride, 5-oxo-2-aryl imadazoldine derivative (18-25) were prepared from the reaction of hydrazone derivatives (2-9) with glycine, while the reaction of hydra

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2

Nora, Amer Hussien, Y. Hussien Hyffaa, and H. Abdulrahman Shaymaa. "Predictive biological activity of newly synthesized hydrazone compounds derived from indomethacin." Journal of Wildlife and Biodiversity 7, Special Issue (2023): 391–402. https://doi.org/10.5281/zenodo.10246323.

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New derivatives of hydrazone have been successfully created, specifically 2-(1-(Aryl)-5-methoxy-2-methyl-1H-indol-3-yl)-N'-(2-chlorobenzylidene) acetohydrazide. The transformation of Indomethacin ester into hydrazide was achieved through a reaction with hydrazine hydrate in absolute ethanol, followed by the reaction of the resulting hydrazide with aromatic aldehydes. The structures of these newly synthesized hydrazones were validated through IR, 1HNMR, and 13CNMR analyses. Each compound's energies were optimized by utilizing density functional theory (DFT) for theoretical calculations. By empl

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3

Agili, Fatimah. "Novel Hydrazide Hydrazone Derivatives as Antimicrobial Agents: Design, Synthesis, and Molecular Dynamics." Processes 12, no. 6 (2024): 1055. http://dx.doi.org/10.3390/pr12061055.

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Ester 2 was produced by reacting thiourea derivative 1 with ethyl 2-chloro-3-oxobutanoate in MeOH containing piperidine. Hydrazide 3 was produced by reacting the latter ester with hydrazine hydrate in EtOH at reflux. By reacting hydrazide 3 with aromatic/heterocyclic aldehydes, twelve derivatives of hydrazide hydrazone 5a–l were produced. Spectral measurements and elemental analysis verified the molecular structure. Compounds 2, 5a, 5c, 5d, and 5f had strong effects on all the pathogenic bacterial strains according to an evaluation of the antimicrobial qualities of the synthetic compounds. Wit

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4

Kaur, Aneet Kamal, Renu Bala, Poonam Kumari, Sumit Sood, and Karan Singh. "Microwave Assisted Vilsmeier-Haack Reaction on Substituted Cyclohexanone Hydrazones: Synthesis of Novel 4,5,6,7-Tetrahydroindazole Derivatives." Letters in Organic Chemistry 16, no. 3 (2019): 170–75. http://dx.doi.org/10.2174/1570178615666180917101637.

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Vilsmeier-Haack reaction is one of the most important chemical reactions used for formylation of electron-rich arens. Even though Vilsmeier-Haack reaction was studied on a wide variety of hydrazones of enolizable ketones, literature lacks the examples of the use of 4-substituted cyclohexanones as a substrate. The cyclization potential of hydrazones of cyclic keto compounds is still interested topic of investigation. In the present study, the reaction of various hydrazines with 4-substituted cyclohexanones was proceeded and the resulted hydrazones in crude form were treated with Vilsmeier- Haac

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5

Al-Shiekh, Mariam A., Hanady Y. Medrassi, Mohamed H. Elnagdi, and Ebtisam A. Hafez. "Substituted Hydrazonals as Building Blocks in Heterocyclic Synthesis: A New Route to Arylhydrazonocinnolines." Journal of Chemical Research 2007, no. 7 (2007): 432–36. http://dx.doi.org/10.3184/030823407x234617.

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2-heteroylhydrazonopropanals 2a–e and 3-oxo-2-arylhydrazonopropanals 2f–k were prepared via coupling of enaminones 1 with aromatic diazonium salts. Compounds 2a–c condensed with hydrazine hydrate to yield the corresponding hydrazones 3a–c which afford on cyclisation the cinnoline derivatives 6a–c, while condensation of 2g, j with hydrazine hydrate directly yielded the pyrazole derivatives 4g–j. Condensation of 2a–c, f, g with phenyl hydrazine gave the corresponding phenyl hydrazone derivatives 7a–c, f, g. Structures of 2a, h and 3a were assessed by single crystal X-ray analyses.

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6

Hishmat, O. H., S. S. Mabrouk, A. M. M. Nasef, N. M. A. Shayeb, and S. A. Ismail. "Derivatives of Khellinonequinone and their Aflatoxigenic Activity." Zeitschrift für Naturforschung B 43, no. 3 (1988): 343–46. http://dx.doi.org/10.1515/znb-1988-0318.

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Nitration of khellinone leads to the formation of a small amount of 3-nitrokhellinone and 5-acetyl-6-hydroxybenzofuran-4.7-dione (khellinonequinone) as a main product. The latter compound reacts with primary amines to give the corresponding imino compounds. Reaction of khellinone with o-phenylenediamine involves condensation followed by cyclisation. While on the other hand treating with phenyl hydrazines gives the phenyl hydrazone. The pyrazolobenzofuran derivative was obtained by the action of hydrazine hydrate on khellinonequinone. Finally the reaction with malononitrile leads to the formati

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7

Abdelmohsen, Shawkat A., and Talaat I. El Emary. "SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL ACTIVITY OF NOVEL PYRAZOLO[3,4-b]PYRIDINES AND THEIR SPIRO-HETEROCYCLIC DERIVATIVES." JOURNAL OF ADVANCES IN CHEMISTRY 10, no. 7 (2014): 2901–15. http://dx.doi.org/10.24297/jac.v10i7.6802.

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The present work describes the synthesis of a novel series of heterocyclic moieties derived from 5-acetylpyrazolo[3,4-b]pyridine (1). The formation of chalcones (2a-d) was utilized to synthesize pyrazoline, isoxazoline and pyrimidine derivatives (3-10). Thiosemicarbazone and semicarbazone (11, 17) were utilized to synthesize other new triazolethiones, thiadiazole and selenadiazole derivatives (11-19). Some new spiro derivatives (22-25) were synthesized by the reaction of chalcone (21) of 1 and isatine with hydrazines, hydroxyl amines and thiourea. Also, The reaction of 1 with cyanoacetyl hydra

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8

Edrees, Mastoura M. "Synthesis of 4-hydrazinopyrazolo[3,4-d]pyrimidines and their Reactions with Carbonyl Compounds." Journal of Chemical Research 37, no. 1 (2013): 6–10. http://dx.doi.org/10.3184/174751912x13543818811749.

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Synthesis of a new 4-hydrazinopyrazolo[3,4- d]pyrimidine was achieved via heating (4,6-dithioxo-1 H-pyrazolo[3,4- d] pyrimidin-3-yl)acetonitrile with hydrazine hydrate. Reactions of the latter product with thiophene-2-carbaldehyde and ethyl hydrazonoacetoacetate analogues afforded the corresponding hydrazone and pyrazole derivatives, respectively. Similarly, condensation of 2-[6-(benzylsulfanyl)-4-hydrazino-1 H-pyrazolo[3,4- d]pyrimidin-3-yl]acetonitrile with thiophene-2-carbaldehyde and ethyl hydrazonoacetoacetate analogues gave the respective hydrazone and pyrazolone derivatives. Alkylation

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9

Prateeptongkum, Saisuree, Nongnaphat Duangdee, and Wiratchanee Mahavorasirikul. "Evaluation of Cytotoxicity and Apoptosis Induced by Coumarin Hydrazide-Hydrazone Derivatives in Human Hepatocellular Carcinoma Cell Line." Trends in Sciences 21, no. 7 (2024): 7628. http://dx.doi.org/10.48048/tis.2024.7628.

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Coumarin and aryl hydrazide-hydrazone have attracted our attention due to their vast biological properties. Previous studies suggested that coumarin-tethered aryl hydrazide-hydrazone showed potent activities against HepG2. In the present study, we investigated the cytotoxic potency of the coumarin derivatives 1 - 3 to compare with coumarin hydrazine-hydrazone hybrids 4 and 5 against hepatocellular carcinoma HepG2 and LH86 cell lines. Among the tested coumarins, hybrids 4 and 5 showed highly potent activity against HepG2 with IC50 values of 17.82 ± 2.79 and 7.87 ± 0.88 𝜇g/mL, respectively. The

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10

Sapkota, Kamal Raj, Shilpi Kumari, Zeba Alam, and Md Serajul Haque Faizi. "Synthesis, and Structural Characterization of (E)-1-(4-((2-(2,4-Dinitrophenyl) hydrazono) methyl)phenyl) piperidine: A Combined Spectroscopic and Computational Study." Bhairahawa Campus Journal 7, no. 1 (2024): 41–55. https://doi.org/10.3126/bhairahawacj.v7i1.79948.

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This study Hydrazine-based piperidine derivatives are widely recognized for their significant roles in pharmaceutical development and material science research. In this context, the present study aimed to synthesize a novel hydrazone derivative to explore its structural and electronic features. This study presents the synthesis and structural characterization of (E)-1-(4-((2-(2,4-Dinitrophenyl)hydrazono)methyl)phenyl)piperidine) (DHP). The compound was obtained through a condensation reaction between 4-(piperidin-1-yl) benzaldehyde and (2,4-dinitrophenyl) hydrazine, achieving an 88% yield. Its

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11

Shalini, Agarwal, and Goyal Anju. "Exploring the Therapeutic Potential of Hydrazide-Hydrazone Derivatives: A Comprehensive Review." Pharmaceutical and Chemical Journal 7, no. 3 (2020): 100–107. https://doi.org/10.5281/zenodo.13954554.

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The exploration of novel compounds with antibacterial, anticancer, and anticonvulsant activities is a significant area of research due to the rising challenges posed by drug-resistant bacterial strains, cancer, and neurological disorders. The continual rise of drug-resistant bacterial strains, the complex challenges associated with cancer, and the persistent enigma of neurological disorders have fueled an ongoing quest for innovative therapeutic agents. Among the myriad compounds under investigation, hydrazide-hydrazone derivatives have emerged as promising candidates with diverse biological a

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12

Abidov, Musa T. "Pharmacological aspects of hydrazides and hydrazide derivatives." Health Promotion & Physical Activity 2, no. 3 (2017): 9–21. http://dx.doi.org/10.5604/01.3001.0010.7718.

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Intense search for new antimicrobials, including anti-tuberculosis drugs, is dictated by the phenomenon of bacterial multidrug resistance. Hydrazides are considered the key intermediate and valuable starting material for some novel biologically active compounds. Over 70% of recently reported synthetic hydrazide derivatives are evaluated for antimicrobial and/or antifungal activity. The most frequently applied hydrazide is an anti- tuberculosis drug isoniazid/isonicotinic acid hydrazide (NIH). Hydrazide chemicals are sharing a common functional group characterized by a nitrogen- to-nitrogen cov

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13

Ahmed, H. Shamroukh, E. Rashad Aymn, T. Gaballah Samir, A. A. Osman Dalia, I. Hashem Ahmed, and M. E. Abdel-Megeid Farouk. "Synthesis of some N-Acyclic Pyrazolopyrimidine Nucleosides and Pyrazolotriazolopyrimidines." Chemistry Research Journal 5, no. 5 (2020): 89–96. https://doi.org/10.5281/zenodo.13144550.

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<strong>Abstract </strong>Pyrazolo[3,4-<em>d</em>]pyrimidin-4-one derivative <strong>1</strong> was used as a key compound for the preparation of some <em>N</em>-acyclic nucleosides of pyrazolo[3,4-<em>d</em>]pyrimidines <strong>2-5</strong>. Also, the synthesis and structure characterization of pyrazolo[3,4-<em>d</em>]pyrimidin-6-yl-hydrazine derivative <strong>6 </strong>was reported as a key compound for the preparation of pyrazolotriazolopyrimidine derivatives <strong>7</strong>-<strong>9 </strong>under different suitable reaction conditions. Cyclization of the hydrazone derivatives <stron

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14

Kalaiarasi, N., and S. Manivarman. "Spectral characterization, microbial activities and toxicity study of some newly synthesized hydrazone derivatives." International Journal of Advanced Chemistry 5, no. 2 (2017): 54. http://dx.doi.org/10.14419/ijac.v5i2.7739.

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Hydrazone derivatives of 2-Thioxodihyropyrimidine-2-dione were synthesized by addition of thiobarbituric acid with phenyl hydrazine, dinitrophenyl hydrazine, semicarbazide, thiosemicarbazide and benzohydrazide respectively. Structures of these synthesized compounds are characterized by means of UV, IR, Proton-NMR, Carbon- NMR. Finally the hydrazone derivatives synthesized are screened for biological activities namely antibacterial and antifungal activities. Also in addition the toxicity studies of the compounds are also performed.

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15

El-Essawy, Farag A., Wael A. El-Sayed, Sherif A. El-Kafrawy, Asmaa S. Morshedy, and Adel-H. Abdel-Rahman. "Anti-Hepatitis B Virus Activity of New 1,2,4-Triazol-2-yl- and 1,3,4-Oxadiazol-2-yl-2-pyridinone Derivatives." Zeitschrift für Naturforschung C 63, no. 9-10 (2008): 667–74. http://dx.doi.org/10.1515/znc-2008-9-1010.

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A number of 1,3,4-oxadiazole, 3 - 9, and 1,2,4-triazole derivatives, 13 - 15, were synthesized starting form the acid hydrazide 1. The 1,3,4-thiadiazole derivative 12 was prepared from the substituted phenylthiosemicarbazide derivative 11 by treatment with sulfuric acid. The aryl hydrazone derivatives 10a - c were synthesized by reaction of the hydrazide 1 with the corresponding ketones. The thioalkyl derivatives 16a - e were prepared by akylation of the thiol derivatives 3 and 13 with different alkylating agents. The newly synthesized compounds were tested for their anti-HBV activity and some

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16

Popiołek, Łukasz. "Updated Information on Antimicrobial Activity of Hydrazide–Hydrazones." International Journal of Molecular Sciences 22, no. 17 (2021): 9389. http://dx.doi.org/10.3390/ijms22179389.

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Hydrazide–hydrazones possess a wide spectrum of bioactivity, including antibacterial, antitubercular, antifungal, anticancer, anti-inflammatory, anticonvulsant, antidepressant, antiviral, and antiprotozoal properties. This review is focused on the latest scientific reports regarding antibacterial, antimycobacterial, and antifungal activities of hydrazide–hydrazones published between 2017 and 2021. The molecules and their chemical structures presented in this article are the most active derivatives, with discussed activities having a hydrazide–hydrazone moiety as the main scaffold or as a side

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17

Asif, Mohammad, and Asif Husain. "Analgesic, Anti-Inflammatory, and Antiplatelet Profile of Hydrazones Containing Synthetic Molecules." Journal of Applied Chemistry 2013 (December 17, 2013): 1–7. http://dx.doi.org/10.1155/2013/247203.

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Hydrazones are present in many of the bioactive compounds with wide interest because of their diverse pharmacological applications. Hydrazones possess wide variety of biological activities such as anticonvulsant, antidepressant, analgesic, anti-inflammatory, antiplatelet, antimicrobial, anticancer, antihypertensive, anthelmintic, antidiabetic, antiparasitic, and other anticipated activities. This created an interest for researchers towards synthesized variety of hydrazone derivatives for different biological activities. Therefore many researchers have synthesized hydrazone derivatives as targe

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18

Nogueira, Thais Cristina Mendonça, Lucas dos Santos Cruz, Maria Cristina Lourenço, and Marcus Vinicius Nora de Souza. "Design, Synthesis and Anti-tuberculosis Activity of Hydrazones and N-acylhydrazones Containing Vitamin B6 and Different Heteroaromatic Nucleus." Letters in Drug Design & Discovery 16, no. 7 (2019): 792–98. http://dx.doi.org/10.2174/1570180815666180627122055.

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Background: The term vitamin B6 refers to a set of six compounds, pyridoxine,pyridoxal ,and pyridoxamine and their phosphorylated forms, among which pyridoxal 5´-phosphate (PLP) is the most important and active form acting as a critical cofactor. These compounds are very useful in medicinal chemistry because of their structure and functionalities and are also used in bioinorganic chemistry as ligands for complexation with metals. Methods: In this study, a series of hydrazones 1a-g and N-acylhydrazones 2a-f containing vitamin B6 have been synthesized from commercial pyridoxal hydrochloride and

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19

Hajipour, Abdol Reza, Iraj Mohammadpoor-Baltork, and Mansour Bigdeli. "A Convenient and Mild Procedure for the Synthesis of Hydrazones and Semicarbazones from Aldehydes or Ketones under Solvent-free Conditions." Journal of Chemical Research 23, no. 9 (1999): 570–71. http://dx.doi.org/10.1177/174751989902300926.

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20

Hamada, Nagwa M. M., Sohila H. Mancy, and Mohamed A. El Sekily. "A Facile Synthesis, Spectroscopic Identification, and Antimicrobial Activities of Some New Heterocyclic Derivatives from D-erythro-2,3-hexodiuloso-1,4-lactone-2-(o-chlorophenyl hydrazone)-3-oxime." International Journal of Chemistry 16, no. 2 (2024): 62. http://dx.doi.org/10.5539/ijc.v16n2p62.

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A new series of different heterocyclic derivatives was prepared via a facile unimolecular condensation of D-iso ascorbic acid with o-chlorophenyl hydrazine to give D-erythro-2,3-hexodiulosono-1,4-lactone 2-( o-chlorophenyl hydrazine (2). Reactions of&nbsp;(2)&nbsp;with hydroxylamine gave the 2-( o-chlorophenyl hydrazone)-3-oxime (3). On boiling with boiling acetyl chloride,&nbsp;(3)&nbsp;gave 2-o-chlorophenyl-4-(2,3-di-O-acetyl-D-erythro-glyceryl-1-yl)-1,2,3-triazole-5-carboxylic acid-5,1́-lactone (4). In the treatment of (3) with benzoyl chloride in pyridine the same dehydrati

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21

Hamada, Nagwa M. M., Sohila H. Mancy, and Mohamed A. El Sekily. "A Facile Synthesis, Spectroscopic Identification, and Antimicrobial Activities of Some New Heterocyclic Derivatives from D-erythro-2,3-hexodiuloso-1,4-lactone-2-(o-chlorophenyl hydrazone)-3-oxime." International Journal of Chemistry 17, no. 2 (2025): 50. https://doi.org/10.5539/ijc.v17n2p50.

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A new series of different heterocyclic derivatives was prepared via a facile unimolecular condensation of D-iso ascorbic acid with o-chlorophenyl hydrazine to give D-erythro-2,3-hexodiulosono-1,4-lactone 2-( o-chlorophenyl hydrazine (2). Reactions of&nbsp;(2)&nbsp;with hydroxylamine gave the 2-( o-chlorophenyl hydrazone)-3-oxime (3). On boiling with boiling acetyl chloride,&nbsp;(3)&nbsp;gave 2-o-chlorophenyl-4-(2,3-di-O-acetyl-D-erythro-glyceryl-1-yl)-1,2,3-triazole-5-carboxylic acid-5,1́-lactone (4). In the treatment of (3) with benzoyl chloride in pyridine the same dehydrati

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22

Alheety, Nuaman. "Synthesis, Characterization and Antimicrobial Activity Study of Some New Substituted Benzoxazole Derivatives." Baghdad Science Journal 16, no. 3 (2019): 616. http://dx.doi.org/10.21123/bsj.2019.16.3.616.

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This research included the preparation of 2-mercaptobenzoxazole (N1) by the reaction of ortho-aminophenol with carbon disulfide in an alcoholic potassium hydroxide solution. The 2-mercapto benzoxazole (N1) was then treated with hydrazine to obtain the 2-hydrazino benzoxazole (N2). A number of hydrazones (N3-N5) were prepared through the reaction of N2 with different benzaldehydes. The compound (N6) was also prepared whereby the ring closing of hydrazone (N3) using chloroacetylchloride, while the compound (N7) was prepared by treating 2-hydrazino benzoxazole with acetylacetone. When the compoun

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23

Atta-Allah, Saad R., Wael S. I. Abou-Elmagd, Kamal A. A. Kandeel, Magdy M. Hemdan, David S. A. Haneen, and Ahmed S. A. Youssef. "Synthesis and Antimicrobial Activity Evaluation of Some Novel Hydrazone, Pyrazolone, Chromenone, 2-Pyridone and 2-Pyrone Derivatives." Journal of Chemical Research 41, no. 11 (2017): 617–23. http://dx.doi.org/10.3184/174751917x15065183733150.

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A cyanoacetohydrazide derivative underwent a series of reactions with different nucleophilic reagents, such as hydrazine hydrate, p-chlorobenzaldehyde and salicylaldehyde, to give the condensation products. In addition, an arylidene malononitrile was reacted with different nitrogen nucleophiles, such as hydrazine hydrate, thiocarbohydrazide and cyanoacetohydrazide, to afford the hydrazine, hydrazone and pyridin-2-one derivatives, respectively. Furthermore, a pyridin-2-one derivative was reacted with different carbon electrophiles, such as carbon disulfide, p-chlorobenzaldehyde and acetic anhyd

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24

Wu, Shouting, Xi Liang, Fang Luo, et al. "Synthesis, Crystal Structure and Bioactivity of Phenazine-1-carboxylic Acylhydrazone Derivatives." Molecules 26, no. 17 (2021): 5320. http://dx.doi.org/10.3390/molecules26175320.

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A phenazine-1-carboxylic acid intermediate was synthesized from the reaction of aniline and 2-bromo-3-nitro-benzoic acid. It was then esterified and reacted with hydrazine hydrate to afford phenazine-1-carboxylic hydrazine. Finally, 10 new hydrazone compounds 3a–3j were obtained by the condensation reaction of phenazine-1-carboxylic acid hydrazide and the respective aldehyde-containing compound. The structures were characterized by 1H and 13C NMR spectroscopy, MS and single crystal X-ray diffraction. The antitumor activity of the target compounds in vitro (HeLa and A549) was determined by thia

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Ünver, Hakan, Burak Berber, Rasime Demirel, and Ayşe T. Koparal. "Design, Synthesis, Anti-Proliferative, Anti-microbial, Anti-Angiogenic Activity and In Silico Analysis of Novel Hydrazone Derivatives." Anti-Cancer Agents in Medicinal Chemistry 19, no. 13 (2019): 1658–69. http://dx.doi.org/10.2174/1871520619666190318125824.

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Background: Cancer is the second leading cause of death globally. Hydrazone and hydrazone derivatives have high activity, and for this reason, these compound are greatly used by researchers to synthesize new anti-cancer drug. The aim of this research work is to synthesize novel anticancer agents. Methods: New hydrazone derivatives were synthesized via a reaction between 3-formylphenyl methyl carbonate and benzhydrazide, 4-methylbenzoic hydrazide, 4-tert-butylbenzoic hydrazide, 4-nitrobenzoic hydrazide and 3- methoxybenzoic hydrazide, and were successfully characterized using elemental analysis

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26

Agarwal, Mahadev, Neelam Singla, and S. K. Singh. "Novel Synthesis, Physicochemical Characterization of 1,3,4-Oxadiazinoindole Derivatives for the Purpose of Antidepressant Activity." INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY 13, no. 03 (2023): 936–41. http://dx.doi.org/10.25258/ijddt.13.3.26.

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The present study synthesized a series of 1,3,4-oxadiazinoindole moiety-containing compounds by combining MAOI’s hydrazide moiety and tricyclic moiety having antidepressant activity. The formation of amino acid chloride from amino acids started the synthesis. Further, they were converted into amino acid hydrazide, and then amino acid hydrazones were prepared by reaction of amino acid hydrazide with isatin. Finally, cyclization was acted on hydrazone-containing compounds in the presence of cold H2SO4. Synthesized compounds are characterized and confirmed via mass spectroscopy, 1H-nuclear magnet

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27

Jasril, E. Juwiyatri, S. N. Fauza, and N. Afriana. "Synthesis, in vitro Antioxidant Activity, and Toxicity Evaluation of Hydrazone Derivatives Naphthalene-1-ylmethylene hydrazine." Journal of Physics: Conference Series 2049, no. 1 (2021): 012050. http://dx.doi.org/10.1088/1742-6596/2049/1/012050.

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Abstract Hydrazone is a versatile organic compound that has a basic structure (-NHN=CH-) called the azomethine group. This structure is responsible for the physical and chemical of hydrazone, which makes this compound has variety bioactivities such as antioxidant, antitumor, and anticancer. In this work, two hydrazone derivatives from 1-naphthaldehyde and hydrazine (phenylhydrazine/hydrazine hydrate) have been synthesized under microwave irradiation. Their antioxidant activity and toxicity were evaluated by DPPH and BSLT method, respectively. Structures of the synthesized compounds were confir

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28

Shaji, Neethu, Sandhya M J Nair, and Shaiju S Dharan. "Coumarin Hydrazide: Chemistry, Synthesis and Pharmacological Activities - A Review." International Journal of Research and Review 9, no. 12 (2022): 16–26. http://dx.doi.org/10.52403/ijrr.20221202.

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Coumarins are heterocyclic compound with a benzopyrone structure. Coumarins are a large group of organic compounds found in several plants even in bacteria and fungi. The biological activities of coumarins and its derivatives includes anticoagulant, anticancer, antiulcer, antifungal, anti-HIV, antimicrobial, antiosteoporosis, antioxidant and anti- inflammatory activity. Hydrazide-hydrazone derivatives act as structural sub units in many pharmacologically active compounds including coumarins to give biological activities like antimicrobial, anticancer, antifungal, anti-inflammatory, antiviral,

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29

Gera, Ankur, Chander Mohan, and Sandeep Arora. "Synthesis of Phthaloylglycyl Hydrazide Derivatives: Selective Protection of Phthalimide Group from Hydrazinolysis." Current Organic Synthesis 15, no. 6 (2018): 839–45. http://dx.doi.org/10.2174/1570179415666180601083256.

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Background: N-phthalimide amino acid hydrazide is a class of compounds that have the potential therapeutic use. In general, hydrazinolysis of N-substituted amino acid(s) ester removes the ester group and yields the corresponding hydrazide. However, in case if N-substitution group is phthalimide, phthalimide group is cleaved and not the ester group. The resulted compound, therefore, is amino acid ester rather than Nphthalimide amino acid hydrazide. The above class of compounds, because of susceptibility of phthalimide group to hydrazinolysis, has previously been synthesized by a lengthy three-s

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30

R., Vasanthi* P. Shyam Sundar H. Ramana K. N. V. Rao Sariya Nayyar K. Rajeswardutt. "SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL EVALUATION OF SOME NOVEL 3-HYDRAZONE-1HBENZOINDOL-2(3H)-ONES." Indo American Journal of Pharmaceutical Sciences 04, no. 10 (2017): 3859–63. https://doi.org/10.5281/zenodo.1034541.

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A novel analogue of 3-Hydrazone-1H-benzoindol-2(3H)-one derivatives were synthesized by condensation of 1H-benzoindole-2, 3-dione with various hydrazine derivatives in the presence of methanol. The synthesized compounds were characterized by IR, 1HNMR spectroscopy and newly synthesized compounds evaluated for their antimicrobial studies. Keywords: Hydrazine, Methanol, Spectroscopy, Antimicrobial activity

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Polat Çakır, Sıdıka, та Sinem Altınışık. "Synthesis of E-Isomer of α-Hydrazone Phosphonates via Nucleophilic Addition of Trialkyl Phosphite to Nitrile Imines (NIs) and DFT Calculations". Journal of Advanced Research in Natural and Applied Sciences 10, № 2 (2024): 415–25. http://dx.doi.org/10.28979/jarnas.1418948.

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Nitrile imines (NIs) belong to the nitrilium betaine family of 1,3-dipoles. Due to their high reactivity, NI compounds cannot be isolated and must be generated in situ before undergoing the desired transformation. NI derivatives were prepared by the utilization of N-phenyl hydrazine chloride precursors in the presence of a base. The title compounds α-hydrazone phosphonates have the potential to be biologically active and may serve as a precursor compound for other biologically active substances like amino phosphonic acids. Shortly, they are highly significant compounds in medicinal and synthet

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32

Ain, Noor ul, Tariq Mahmood Ansari, M. Rehan H. Shah Gilani, et al. "Facile and straightforward synthesis of Hydrazone derivatives." Journal of Nanomaterials 2022 (March 11, 2022): 1–6. http://dx.doi.org/10.1155/2022/3945810.

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This study was undertaken to report the swift, facile and convenient synthesis of novel hydrazones obtained by condensation reaction between 2-Amino-3-formylchromone and hydrazine derivatives. Various characterization techniques such as MALDI Mass, FTIR, 1HNMR and 13CNMR spectrum analysis was done to determine the chemical structure of these novel six hydrazones. Furthermore, UV-Vis and fluorescence spectra was studied to calculate λmax and εmax. These hydrazones are quite useful for their facile synthesis and chemical structure. Such hydrazones require separate clinical research to find their

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33

Fatullayeva, P. A. "COMPLEXES OF METALS WITH HYDRAZONE HYDRAZIDE SALICYLIC ACID." Chemical Problems 19, no. 2 (2021): 79–83. http://dx.doi.org/10.32737/2221-8688-2021-2-79-83.

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Complexes of Cu (II), Ni (II), and Co (II) with hydrazone derivatives of salicylic acid hydrazide and 3,5-di-tert-butyl salicylic aldehyde (LH) were synthesized and the structure of these compounds studied by means of elemental analysis methods, IR and electronic spectroscopy, magnetochemistry and thermal analysis. It revealed that the complexes are monomeric and have a composition [MLXSoI] where M is a metal ion, L is a ligand, X is an inorganic anion, and Sol is a solvent molecule. LH- in the complexes behaves like a monoanionic tridentate ligand. It found that the resulting complexes exhibi

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34

Journal, Baghdad Science. "Synthesis of Some Heterocyclic Compounds Derived from 2-Mercapto Benzoxazole." Baghdad Science Journal 10, no. 3 (2013): 766–78. http://dx.doi.org/10.21123/bsj.10.3.766-778.

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New series of 2-mecapto benzoxazole derivatives (1-20) incorporated into fused to different nitrogen and suphur containing heterocyclic were prepared from 2-meracpto benzoxazole, when treated with hydrazine hydrate to afford 2-hydrazino benzoxazol (1). Compound (1) converted to a variety of pyridazinone andphthalazinone derivatives (2-4) by reaction with different carboxylic anhydride. Also, reaction of (1) with phenyl isothiocyanate and ethyl chloro acetate afforded 3-phenyl-1,3-thiazolidin-2,4-dione-2-(benzoxazole-2-yl-hydrazone) (6). Azomethines (7-10) were prepared through reaction of (1)

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35

Askar, Firyal W., Huda A. Hassan, and Nahida A. Jinzeel. "Synthesis of Some Heterocyclic Compounds Derived from 2-Mercapto Benzoxazole." Baghdad Science Journal 10, no. 3 (2013): 766–78. http://dx.doi.org/10.21123/bsj.2013.10.3.766-778.

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New series of 2-mecapto benzoxazole derivatives (1-20) incorporated into fused to different nitrogen and suphur containing heterocyclic were prepared from 2-meracpto benzoxazole, when treated with hydrazine hydrate to afford 2-hydrazino benzoxazol (1). Compound (1) converted to a variety of pyridazinone andphthalazinone derivatives (2-4) by reaction with different carboxylic anhydride. Also, reaction of (1) with phenyl isothiocyanate and ethyl chloro acetate afforded 3-phenyl-1,3-thiazolidin-2,4-dione-2-(benzoxazole-2-yl-hydrazone) (6). Azomethines (7-10) were prepared through reaction of (1)

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36

KushalNath Mishra, Shambaditya Goswami, Kumudhavalli M.V, et al. "Hydrazones and their metal complexes: A short review on their biological potentia." International Journal of Research in Pharmaceutical Sciences 11, SPL4 (2020): 1440–47. http://dx.doi.org/10.26452/ijrps.v11ispl4.4319.

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Hydrazones belong to complexes are beneficial in different fields for their essential role in the development of a range of stable complexes in the coordination chemistry. Different researchers have reported the various medicinal properties of hydrazones. Hydrazone and its metal complexes are useful for the detection of some organic components from pharmaceutical formulations. These metallic compounds act as a catalyst for conducting various chemical reactions and help in making different chemical complexes that are effective against bacteria, fungi, and many other microbes. Aromatic hydrazone

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37

Dziduch, Katarzyna, Sara Janowska, Sylwia Andrzejczuk, et al. "Synthesis and Biological Evaluation of New Compounds with Nitroimidazole Moiety." Molecules 29, no. 13 (2024): 3023. http://dx.doi.org/10.3390/molecules29133023.

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Heterocyclic compounds, particularly those containing azole rings, have shown extensive biological activity, including anticancer, antibacterial, and antifungal properties. Among these, the imidazole ring stands out due to its diverse therapeutic potential. In the presented study, we designed and synthesized a series of imidazole derivatives to identify compounds with high biological potential. We focused on two groups: thiosemicarbazide derivatives and hydrazone derivatives. We synthesized these compounds using conventional methods and confirmed their structures via nuclear magnetic resonance

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38

A., H. SIDDIQUI, VENKATESHWER RAO K., and VIJAYASENA REDDY K. "Synthesis of Steroidal Extranucleo N-Phenyloxazolidones of Androstane Series." Journal of Indian Chemical Society Vol. 65, Dec 1988 (1988): 850–51. https://doi.org/10.5281/zenodo.6089596.

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Department of Chemistry, Nizam College, Hyderabad-500 001 <em>Manuscript received 13 May 1988, accepted 23 August 1988</em> 17-Oxo-5-androsten-3\(\beta\)-yl acetate (1a) and 3\(\beta\) -chloro-17-oxo-5-androstene (2a) on reaction with hydrazine hydrate in alcoholic solution gave 5-androsten-17-hydrazone-3\(\beta\) -yl acetate (1b) and 3\(\beta\) -chloro-5-androsten-17-hydrazone (2b), respectively. The subsequent reaction of these 17-hydrazones (1b, 2b) with phenyl isocyanate in benzene solution afforded the corresponding 17-<em>N</em>-pbenylsemlcarbazone derivatives (1c, 2c

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39

M. Samir, E., and R. M. Mohareb. "Novel synthesis of pyran-3-hydrazide derivatives and their uses to the synthesis hydrazide-hydrazone, pyrazole and thiazole derivatives with anticancer activities." Bulletin of the Chemical Society of Ethiopia 35, no. 3 (2022): 573–86. http://dx.doi.org/10.4314/bcse.v35i3.9.

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ABSTRACT. The multi-component reaction of ethyl acetoacetate with each of malononitrile (3) benzaldehyde (1) in ethanol containing triethylamine gave the ethyl 6-amino-5-cyano-2-methyl-4-phenyl-4H-pyran-3-carboxylate (4). The latter compound reacted with hydrazine hydrate to give the hydrazide derivative 6. Compound 6 underwent a series of hetero-cyclization reactions to give pyrzole, hydraide-hydrazone, thiazole derivatives. The produced compounds tested against cancer cell lines six cancer cell lines and showed that compounds 8b, 10b, 11a, 17a, 21 and 24a were the most cytotoxic compounds. F

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40

Nocheva, Hristina, Stanislava Vladimirova, Diana Tzankova, Lily Peikova, and Maya Georgieva. "Analgesic properties of newly synthesized N pyrrolyl hydrazide hydrazones." Tropical Journal of Pharmaceutical Research 22, no. 1 (2023): 121–27. http://dx.doi.org/10.4314/tjpr.v22i1.17.

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Purpose: To screen a series of newly synthesized N-pyrrolyl hydrazide hydrazones for analgesic activity via Paw-pressure (PP) test and hot plate test (HPT). Methods: The compounds newly synthesized through the classical Paal-Knor cyclization, N-pyrrolyl hydrazide-hydrazones were administered intraperitoneally at a dose of 20 mg/kg. Paw pressure and hot plate tests were applied to assess the analgesic properties. In addition, stress-induced analgesia with naloxone as a non-selective opioid receptor antagonist was performed. Results: The compound (DI-5g), containing an izatine carbon

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41

Thorat, B. R., S. N. Mali, Umang Shah, et al. "Hydrazide-Hydrazone Derivatives and Their Antitubercular Activity." Russian Journal of Bioorganic Chemistry 51, no. 1 (2025): 35–52. https://doi.org/10.1134/s1068162025010054.

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42

Abd El-Salam, N. M., Z. Y. Al Shoaibi, and G. A. Ahmed. "Chemical Studies on 3,6-Dichloropyridazine (Part 2)." E-Journal of Chemistry 8, no. 4 (2011): 1944–50. http://dx.doi.org/10.1155/2011/612825.

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3,6-Dichloropyridazine (1) reacted with 2-aminophenol, phenylalanine, acetophenone hydrazone derivatives, acid hydrazide derivatives and amino-aromatic acids (anthranilic acid and 5-bromoanthranilic acid) and yield the compounds (2), (3), (4a,b), (5a,b) and (6a,b) respectively. Reaction of compounds (5a,b) with acid hydrazide gave (8a,b). Also, compounds (6a,b) reacted with aromatic amino acid and gave (7a-c).

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43

GOKLANI, POONAM, and ANIL GUPTA. "Synthesis, Structural Characterization and Study of Biological Activity of Hydrazine Derivatives." Material Science Research India 14, no. 2 (2017): 190–93. http://dx.doi.org/10.13005/msri/140217.

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Hydrazide-hydrazone derivatives play vital role in development of various pharmacological activities such as anti-tubercular, antiproliferative and antitumor activities. Some novel biologically active Hydrazide derivatives substituted with heterocyclic moiety have been synthesized. All the synthesized compounds structures were confirmed by IR, NMR and Mass spectra. Synthesized compounds were subjected to antibacterial screening in vitro and biological activity in vivo.

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44

R., M. ISSA, M. ISSA Y., A. ABDEL-LATIF S., and A. ABDEL-SALAM H. "Spectroscopic Studies of some Benzilic Hydrazone Derivatives." Journal of Indian Chemical Society Vol. 74, Sep 1997 (1997): 731–33. https://doi.org/10.5281/zenodo.5896368.

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Chemistry Department, Faculty of Science, Cairo University, Giza, Egypt (Tanta University and Beni Suef Branch) <em>Manuscript received 1 August 1995, revised 6 May 1996, accepted 2 September 1996</em> Spectroscopic Studies of some Benzilic Hydrazone Derivatives.

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45

Marinov, Marin. "SYNTHESIS OF AMINO DERIVATIVES OF MONOTHIO- AND DITHIO- ANALOGUES OF CYCLOHEXANESPIRO-5-HYDANTOIN." Journal scientific and applied research 2, no. 1 (2012): 66–73. http://dx.doi.org/10.46687/jsar.v2i1.45.

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This article presents methods for synthesis of 3-amino derivatives of cyclohexanespiro-5-(2-thiohydantoin) and cyclohexanespiro-5-(2,4-dithiohydantoin). It was found out that the treatment of cyclohexanespiro-5-(2-thiohydantoin) with hydrazine hydrate under different reaction conditions led to obtaining of 3-amino derivative and 2-hydrazone of the initial compound. As a result of thionation of 3-aminocyclohexanespiro-5-hydantoin with P4S10 or Lawesson’s reagent, the corresponding dithio-analogue was synthesized. The structures of the products obtained were verified by IR, 1H NMR, 13C NMR and m

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46

Dohle, Wolfgang, Xiangdong Su, Yamni Nigam, Edward Dudley, and Barry V. L. Potter. "Synthesis and In Vitro Antimicrobial SAR of Benzyl and Phenyl Guanidine and Aminoguanidine Hydrazone Derivatives." Molecules 28, no. 1 (2022): 5. http://dx.doi.org/10.3390/molecules28010005.

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A series of benzyl, phenyl guanidine, and aminoguandine hydrazone derivatives was designed and in vitro antibacterial activities against two different bacterial strains (Staphylococcus aureus and Escherichia coli) were determined. Several compounds showed potent inhibitory activity against the bacterial strains evaluated, with minimal inhibitory concentration (MIC) values in the low µg/mL range. Of all guanidine derivatives, 3-[2-chloro-3-(trifluoromethyl)]-benzyloxy derivative 9m showed the best potency with MICs of 0.5 µg/mL (S. aureus) and 1 µg/mL (E. coli), respectively. Several aminoguani

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47

Farah Smaysem and Ahmed Salim. "Synthesis and Characterization of Some Heterocyclic Compounds and Evaluation of Antibacterial Activity." International Journal of Research in Pharmaceutical Sciences 11, SPL4 (2020): 2068–78. http://dx.doi.org/10.26452/ijrps.v11ispl4.4421.

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In this study, heterocyclic compounds with two nitrogen atoms are prepared by reaction of 2-aminobenzimidazole with formic acid to get amide derivatives (A), reacts with phenylhydrazine to get phenyl hydrazone derivatives (B), reacts with ethyl chloroacetate to obtain ethyl acetate derivatives (C). The derivative (D) obtains on heating in a basic medium. The (B) reacts with 2-chloroacetyl chloride to give derivatives (E). A number of Schiff bases are prepared (F, I) from reacting 2-aminobenzimidazole with benzaldehyde derivatives. The(F) reacts with propargyl bromide to give propargyl bromide

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48

Wameed Raad Abd-allah and Khaled Mtani Al – Janabi. "Preparation and diagnosis of new picolinic acid derivatives." Tikrit Journal of Pure Science 23, no. 6 (2023): 101–10. http://dx.doi.org/10.25130/tjps.v23i6.679.

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In this study, a new series of heterocyclic rings derived from picolinic acid was prepared. The quaternary reaction of acid hydrazone with chloroacetyl chloride was intended to obtain the azitidine-2-on ring known as beta-lactam and the preparation of the seventh ring of acid hydrazone reaction with the anhydride and phthalic anhydride To obtain a 3.1-oxabine loop. The five-ring of the picolinic acid hydrazide reaction with CS2 was also destined to obtain a 4,3,1-oxadiazole-2-thaion ring. The new compounds were diagnosed using FT-IR techniques and resonance technique Nuclear Magnetic H-NMR and

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49

Wu, Jiale, Jiafeng Wang, Yinglong Han, Yu Lin, Jing Wang, and Ming Bu. "Synthesis and Cytotoxic Activity of Novel Betulin Derivatives Containing Hydrazide-Hydrazone Moieties." Natural Product Communications 16, no. 10 (2021): 1934578X2110553. http://dx.doi.org/10.1177/1934578x211055345.

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A series of novel betulin derivatives containing hydrazide-hydrazone moieties were synthesized. All compounds were evaluated for their cytotoxicity against four human carcinoma cell lines (HepG2, A549, MCF-7 and HCT-116) and a normal human gastric epithelial cell line (GES-1). Among them, compound 6i was the most potent against HepG2 and MCF-7 cell lines, with IC50 values of 9.27 and 8.87 μM, respectively. The results suggest that the incorporation of a hydrazide-hydrazone side chain at the C-28 position of betulin is beneficial for compounds to display significant cytotoxicity. Compound 6i ma

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Qiu, Xiao Yang, An Ran Shi, and Xiao Li Zhang. "Synthesis and Cytotoxic Activity of Salicyloyl Hydrazone Derivatives." Applied Mechanics and Materials 320 (May 2013): 522–25. http://dx.doi.org/10.4028/www.scientific.net/amm.320.522.

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Three salicyloyl hydrazone derivatives (compounds 1-3) were prepared by reacting salicyloyl hydrazine with substituted formaldehydes. Their structures were characterized by melting point, 1H-NMR, ESI-MS and elemental analyses. The cytotoxic activity of compounds 1-3 was evaluated in vitro against Hela cells (human cervical cancer cells). The results revealed that all the compounds showed cytotoxic activity, with IC50 values lower than 15 μM.

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