Relevant bibliographies by topics / Hydrazones

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers

Academic literature on the topic 'Hydrazones'

Author: Grafiati
Published: 4 June 2021
Last updated: 16 June 2025

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Journal articles on the topic "Hydrazones"

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Ji, Heng, Hui-qiong Ni, Peng Zhi, et al. "Visible-light mediated directed perfluoroalkylation of hydrazones." Organic & Biomolecular Chemistry 15, no. 28 (2017): 6014–23. http://dx.doi.org/10.1039/c7ob01144j.

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A convenient and efficient protocol was reported to access a series of perfluoroalkylated aromatic aldehyde hydrazones. Aliphatic aldehyde hydrazones and N-monosubstituted hydrazones which are unreactive in previously reported hydrazone perfluoroalkylation reactions now take part in the reaction.
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KushalNath Mishra, Shambaditya Goswami, Kumudhavalli M.V, et al. "Hydrazones and their metal complexes: A short review on their biological potentia." International Journal of Research in Pharmaceutical Sciences 11, SPL4 (2020): 1440–47. http://dx.doi.org/10.26452/ijrps.v11ispl4.4319.

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Hydrazones belong to complexes are beneficial in different fields for their essential role in the development of a range of stable complexes in the coordination chemistry. Different researchers have reported the various medicinal properties of hydrazones. Hydrazone and its metal complexes are useful for the detection of some organic components from pharmaceutical formulations. These metallic compounds act as a catalyst for conducting various chemical reactions and help in making different chemical complexes that are effective against bacteria, fungi, and many other microbes. Aromatic hydrazone derivatives can measure the concentration of low molecular weight aldehyde and ketone complexes. Hydrazones possess numerous medicinal properties, including antimicrobial, anti-cancer, antidepressant, anti-tubercular, anti-viral, etc. For the new drug discovery, hydrazones/azomethines are considered to be an important class of compound. From molecular biology to pharmaceutical formulation, organic chemistry, new drug development process, the importance of hydrazone and its metal complexes is immense. The present review aims to highlight the reported biological activities related to hydrazones for the last decade.
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Asif, Mohammad, and Asif Husain. "Analgesic, Anti-Inflammatory, and Antiplatelet Profile of Hydrazones Containing Synthetic Molecules." Journal of Applied Chemistry 2013 (December 17, 2013): 1–7. http://dx.doi.org/10.1155/2013/247203.

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Hydrazones are present in many of the bioactive compounds with wide interest because of their diverse pharmacological applications. Hydrazones possess wide variety of biological activities such as anticonvulsant, antidepressant, analgesic, anti-inflammatory, antiplatelet, antimicrobial, anticancer, antihypertensive, anthelmintic, antidiabetic, antiparasitic, and other anticipated activities. This created an interest for researchers towards synthesized variety of hydrazone derivatives for different biological activities. Therefore many researchers have synthesized hydrazone derivatives as target structures for their biological activities. This is paper focuses on the analgesic, anti-inflammatory, and antiplatelet activities of hydrazones.
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Kajal, Anu, Suman Bala, Neha Sharma, Sunil Kamboj, and Vipin Saini. "Therapeutic Potential of Hydrazones as Anti-Inflammatory Agents." International Journal of Medicinal Chemistry 2014 (March 4, 2014): 1–11. http://dx.doi.org/10.1155/2014/761030.

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Hydrazones are a special class of organic compounds in the Schiff base family. Hydrazones constitute a versatile compound of organic class having basic structure (R1R2C=NNR3R4). The active centers of hydrazone, that is, carbon and nitrogen, are mainly responsible for the physical and chemical properties of the hydrazones and, due to the reactivity toward electrophiles and nucleophiles, hydrazones are used for the synthesis of organic compound such as heterocyclic compounds with a variety of biological activities. Hydrazones and their derivatives are known to exhibit a wide range of interesting biological activities like antioxidant, anti-inflammatory, anticonvulsant, analgesic, antimicrobial, anticancer, antiprotozoal, antioxidant, antiparasitic, antiplatelet, cardioprotective, anthelmintic, antidiabetic, antitubercular, trypanocidal, anti-HIV, and so forth. The present review summarizes the efficiency of hydrazones as potent anti-inflammatory agents.
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Šandrik, Róbert, Pavol Tisovský, Klaudia Csicsai, et al. "ON/OFF Photostimulation of Isatin Bipyridyl Hydrazones: Photochemical and Spectral Study." Molecules 24, no. 14 (2019): 2668. http://dx.doi.org/10.3390/molecules24142668.

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Four novel isatin hydrazones containing bipyridyl fragments were synthesized as potential ON/OFF switches. Hydrazone Z-isomers exhibit high thermal stability. The characteristic photochemical reaction for all studied hydrazones is the Z–E isomerization in CHCl3. After irradiation of hydrazones 1 and 2 in dimethylformamide (DMF), the photoreaction products are tautomers. When using light with the appropriate wavelength, the photo-tautomerization reaction is reversible. In these conditions, studied hydrazones have ON/OFF switch properties. In the case of hydrazones 1 and 2, by alternating heat and light stimulation it is possible to control the isomerization process reversibly. In the presence of fluoride ions, NH hydrogen from the studied hydrazones is cleaved, and the corresponding anions are formed. The resulting anions of Z-isomers are changed to the corresponding E-isomer at room temperature.
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Jollimore, Jason V., Marc Vacheresse, Keith Vaughan, and Donald L. Hooper. "The effect of ortho and para substituents on the formation of the E and Z isomers of the arylhydrazones obtained from diazonium coupling with methyl 3-aminocrotonate and 3-aminocrotononitrile." Canadian Journal of Chemistry 74, no. 2 (1996): 254–62. http://dx.doi.org/10.1139/v96-029.

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Reaction of arene diazonium salts with 3-aminocrotononitrile or methyl 3-aminocrotonate affords the 2-aryl-hydrazono-3-oxobutanenitrile (1 or 3 and 3′) or the methyl 2-arylhydrazono-3-oxobutanoate (2 and 2′ or 4 and 4′). A series of these hydrazones has been prepared with a range of electron-withdrawing and -donating substituents in the ortho or para position of the aryl moiety. The hydrazones have been characterized by spectroscopic methods, with emphasis on the 1H NMR spectra, which have been used to determine the configuration of the hydrazones as E or Z or a mixture of the two. The para-substituted hydrazononitriles (1) are formed as a single species, namely the Z isomer, whereas the ortho isomers are formed as a mixture of E and Z configurations (3 and 3′). The hydrazonobutanoates (2 and 2′ or 4 and 4′) are formed as E/Z mixtures regardless of the position of the substituent in the aryl moiety. Complete assignments of all signals in the 1H NMR spectra have been made on the basis of the ability of the various substituents to participate in intramolecular hydrogen bonding and a mechanism is proposed to account for the variations in the proportions of E and Z isomers and the effect of the nature of the substituent on this ratio. 13C NMR spectra of selected hydrazones have been recorded as an aid to structure assignment. Key words: hydrazone, diazonium, NMR spectroscopy, E/Z isomers, crotonic acid derivatives.
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Sihag, Monika, and Rinku Soni. "HTIB as an Efficient and Convenient Reagent for Oxidative Cleavage of C=N in Pyrimidinyl Hydrazones." Indian Journal of Heterocyclic Chemistry 33, no. 04 (2023): 393. http://dx.doi.org/10.59467/ijhc.2023.33.393.

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This study is aimed to explore the efficiency of [hydroxy(tosyloxy)iodo]benzene (HTIB) in the oxidative cleavage of some pyrimidinyl hydrazones. The protocol involves stirring the hydrazone derivatives with HTIB in dichloromethane at room temperature. The oxidative cleavage of C = N in pyrimidinyl hydrazones regenerated parent ketones in high yields. The methodology has advantage of preventing over oxidation of carbonyl functionality.
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Wahbeh, Jenna, and Sarah Milkowski. "The Use of Hydrazones for Biomedical Applications." SLAS TECHNOLOGY: Translating Life Sciences Innovation 24, no. 2 (2019): 161–68. http://dx.doi.org/10.1177/2472630318822713.

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The use of hydrazones presents an opportunity for enhancing drug delivery through site-specific drug release, including areas such as tumor tissue or thrombosis. Many researchers are experimenting on how to more efficiently form these hydrazones, specifically using heat and chemical catalysts. Hydrazones respond on the pH environment or are synthesized with particular functional groups of the hydrazone and are two of the many unique features that allow for their programmed drug release. Their flexibility allows them to be relevant in a diverse range of applications, from anti-inflammatory to anticancer to acting as a chelating agent. This review paper discusses efficient ways to optimize the properties of hydrazones and their utilization in various clinical applications, including anticancer, anti-inflammatory, the prevention of platelet aggregation, and roles as chelating agents.
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Rajeev, Jain, Padmaja P., Gupta S., and Gupta Seema. "Electrochemical investigations on some hydrazones." Journal of Indian Chemical Society Vol. 77, Feb 2000 (2000): 91–93. https://doi.org/10.5281/zenodo.5862703.

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School of Studies in Chemistry, Jiwaji University, Gwalior-474 011, India <em>Manuscript received 10 November 1998, revised 2 August 1999, accepted 13 August 1999</em> The electrochemical behaviour of 3-(4&#39;-sulphonamoyl)hydrazono-4-phenylaminobutane-2,4-drones has been studied over a wide pH range at dropping mercury and glassy carbon electrodes. These aryl hydrazones give one four-electron wave/peak cor&shy;responding to the reduction of hydrazono group. The wave/peak is found to be diffusion-controlled and irreversible in na&shy;ture. A reduction mechanism is suggested for the aryl hydrazones.
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Pisk, Jana, Ivica Đilović, Tomica Hrenar, Danijela Cvijanović, Gordana Pavlović, and Višnja Vrdoljak. "Effective methods for the synthesis of hydrazones, quinazolines, and Schiff bases: reaction monitoring using a chemometric approach." RSC Advances 10, no. 63 (2020): 38566–77. http://dx.doi.org/10.1039/d0ra06845d.

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Dissertations / Theses on the topic "Hydrazones"

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Gravelle, Kristian G. "Radical cyclizations of hydrazones." Thesis, University of Ottawa (Canada), 1997. http://hdl.handle.net/10393/9806.

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The preparation of various hydrazones for use in radical cyclizations is described. The radical cyclization of (A) and (B) under various radical conditions led to the tandem cyclization of octahydroindoles (C) and (D) under neutral conditions. The reaction of (E) under various radical conditions led to the first synthesis of a seven membered ring by attack of a carbon radical onto a carbon-nitrogen multiple bond, forming (F).* ftn*Please refer to the dissertation for diagrams.
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Gravelle, Kristian. "Radical cyclizations of hydrazones." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp04/mq20975.pdf.

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Perry, Matthew William Dampier. "Synthetic applications of hydrazones." Thesis, University of Oxford, 1985. http://ora.ox.ac.uk/objects/uuid:5009520c-850a-4030-a8b2-2245b4abe264.

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This thesis describes investigations of reactions of hydrazones and their N-anions via the imino carbon atom; these reactions show umpolung reactivity. The conversion of the derived azo products into synthetically useful compounds (e.g. 4-ketoesters, 4-ketoacids, 4-ketonitriles, alkanes, amines) is also described. Reactions of ṯ-butylhydrazone anions with enoic esters are described. 4-ṯ-Butylazoesters were formed on reaction with methyl crotonate. The 4-ṯ-butylazoesters derived from aldehyde ṯ-butylhydrazones were converted by tautomerisation of the azo function and hydrolysis of the resultant ṯ-butylhydrazone to 4-ketoesters or 4-ketoacids in 47-60% yield. Other Michael type electrophiles investigated gave negligible yields of C-adducts. ṯ-Butylhydrazones of aliphatic aldehydes were found to give ene adducts with methyl acrylate or aerylonitrile on reflux in xylene for 24h. The resultant azo compounds were converted into 4-ketoesters (75-90%) or 4-Ketonitriles (18- 75%) by tautomerisation and hydrolysis. Other potential enophiles investigated did not give C-adducts. A synthesis of a ṯ-butylazoalkene from an aldehyde ṯ- butylhydrazone and benzaldehyde by addition and dehydrative elimination is described. The reduction of ṯ-butylazoalkenes with zinc-acetic acid is described. The C-alkylation of tritylhydrazone anions with alkyl halides gave tritylazoalkanes. Tritylazoalkanes decomposed by homolytic fragmentation with dinitrogen evolution above -20°C. Trapping with ethanethiol of the resultant radicals gave alkanes in 27-69% yield. The last section describes investigations of the anions of various secondary alkyl hydrazones for C-reaction, and attempted reduction of the resultant azoalkanes to amines Isopropyl- and cyclohexylhydrazones gave low yields of Cadducts. 2,4-Dimethylpent-3-yl- (DMP) and 3,3-dimethylbut- 2-ylhydrazones (TBM) gave good yields of C-adducts. Direct reduction of the azoalkanes to amines was not achieved Azoalkanes derived by alkylation of ketone DMP or TBM hydrazones were tautomerised and hydrolysed to hydrazines in low yield. Reduction of a so-formed hydrazine gave an amine, but in low overall yield (14%).
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Prieto, Alexis. "Fluoroalkylation métallo-catalysée des hydrazones." Thesis, Lyon, 2016. http://www.theses.fr/2016LYSE1172/document.

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La chimie du fluor suscite un intérêt croissant de la part des chimistes organiciens de par son exploitation industrielle dans les domaines pharmaceutique et agrochimique. Ainsi, depuis plusieurs années, de nouvelles méthodes permettant d'introduire de manière efficace et sélective des groupements fluorés - et plus particulièrement des fluoroalkyles - sur des molécules cibles sont activement recherchées. Les hydrazones sont des molécules largement utilisées en synthèse organique, notamment comme précurseurs de nombreux composés très recherchés par les industries pharmaceutiques ou agrochimiques, incluant les amines primaires et les hétérocycles azotés tels que les pyrazoles et les indoles. Dans le cadre de cette thèse, nous nous sommes intéressés à la fluoroalkylation des hydrazones. Les premières études ont visé la trifluorométhylation cupro-catalysée d'hydrazones d'aldéhydes et de cétones, lesquelles ont conduit respectivement à la formation d'hydrazones trifluorométhylées et de diimides alpha-trifluorométhylés. Par la suite, cette transformation a été entendue à la béta-trifluorométhylation régiosélective d'hydrazones alpha,béta-insaturées. Enfin, nous nous sommes intéressés au développement de réactions de difluoroalkylation d'hydrazones d'aldéhydes catalysées par le palladium ou le cuivre. Les divers composés obtenus lors de ces études se sont avérés être d'excellents précurseurs de cétones et d'indoles trifluorométhylés, d'alpha,alpha-difluoro-béta-cétoesters, ou encore d'alpha,alpha-difluorocétones<br>Fluorine chemistry is attracting the growing interest of organic chemists due to its industrial exploitation in the pharmaceutical and agrochemical fields. Thus, new methods for the effective and selective introduction of fluorinated groups – and particularly fluoroalkyls - on target molecules have been sought in recent years. Hydrazones are widely used reagents in organic synthesis, notably as precursors of many compounds pursued by the pharmaceutical or agrochemical industries, including primary amines and nitrogen heterocycles such as pyrazoles and indoles. This thesis work focused on the fluoroalkylation of hydrazones. The first studies have been directed toward the copper-catalyzed trifluoromethylation of aldehyde- and ketone-derived hydrazones, which led to the formation of trifluoromethylated hydrazones and alpha-trifluoromethylated azenes, respectively. Subsequently, this transformation was extended to the regioselective beta-trifluoromethylation of alpha,beta-unsaturated hydrazones. Finally, our interest focused on the development of difluoroalkylation reactions of aldehyde-derived hydrazones under palladium or copper catalysis. The various compounds obtained in these investigations have proven to be valuable precursors of trifluoromethylated ketones and indoles, alpha, alpha-difluoro-beta-ketoesters, as well as alpha,alpha-difluoroketones
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Belkheiri, Nadji. "Dérivés phénoliques à activités antiathérogènes." Toulouse 3, 2010. http://thesesups.ups-tlse.fr/961/.

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Les maladies cardio-vasculaires (MCV) représentent la première cause de mortalité et de morbidité dans les pays industrialisés. Il a été clairement démontré que la peroxydation des lipoprotéines, essentiellement les lipoprotéines de faible densité (LDL), constitue une étape critique d'un processus très complexe aboutissant à l'athérosclérose. En effet, l'augmentation relative des espèces réactives de l'oxygène (ERO) due au stress oxydant, induit par le biais des lipoprotéines de basse densité oxydées (LDLox), un dysfonctionnement vasculaire. Les dérivés phénoliques sont connus pour leurs propriétés antioxydantes et plus particulièrement leurs propriétés piégeurs de radicaux libres. D'autre part, les hydrazones sont des piégeurs de carbonyles efficaces. Dans ce cadre, les travaux décrits dans ce manuscrit sont centrés sur la recherche de nouvelles molécules duales possédant des propriétés antioxydantes et cytoprotectrices vis-à-vis de l'action délétère des carbonyles issus de la peroxydation lipidiques des LDLs. Sur la base des résultats antérieurs du laboratoire, nous avons conçu et synthétisé un ensemble de dérivés phénoliques nouveaux issus d'une même brique moléculaire : la bisvanilline. Des bishydrazones symétriques et/ou disymétriques possédant dans ce cas une fonction vinyl-phosphonate et une fonction hydrazone ont été préparées et étudiées. Dans le même temps, les monohydrazones correspondantes issues du syringaldéhyde ont été synthétisées et testées. Dans un premier temps, les effets antioxydants et cytoprotecteurs ont été déterminés pour toutes les molécules synthétisées. Les composés les plus efficaces ont ensuite subi des tests complémentaires, pour évaluer leurs effets piégeurs de carbonyles, de radicaux NO° et O2-° dans des systèmes cellulaires (études in vitro). Les résultats obtenus montrent sans ambiguité que, pour la première fois, nous avons synthétisé des molécules possédant à la fois une activité antioxydante et un effet piégeur de carbonyle. Enfin, l'activité in vivo du composé le plus actif, a été évaluée. Dans un second temps, des études physicochimiques ont été menées afin de comprendre le mode d'action de ces composés à travers trois activités potentielles en liaison avec leurs propriétés antiathérogènes. Ces tests sont basés sont sur : -La capacité des composés synthétisés à piéger les radicaux stables DPPH• et ABTS•+. -Les propriétés complexantes des ces composés vis-à-vis du métal Cu. -L'action inhibitrice du composé le plus actif vis-à-vis de la production in vitro de l'anion superoxyde O2-°<br>Cardiovascular disease (CVD) are the leading cause of mortality and morbidity in industrialized countries. It has been clearly shown that peroxidation of lipoproteins, mainly low density lipoprotein (LDL), is a critical stage of a very complex process leading to atherosclerosis. Indeed, the relative increase of reactive oxygen species (ROS) due to oxidative stress, induced by means of oxidized low density lipoprotein (oxLDL), a vascular dysfunction. The phenolics are known for their antioxidant properties, especially their free radical scavengers. On the other hand, the hydrazones are effective scavengers carbonyls. In this context, the work described in this manuscript are focused on the research of new molecules with dual cytoprotective and antioxidant properties vis-à-vis the deleterious action of carbonyls from lipid peroxidation of LDL. Based on previous results of the laboratory, we designed and synthesized a new set of phenolics from the same brick molecular the bisvanilline. Bishydrazones of symmetrical and / or with dissymmetry in this case is a function of vinyl-phosphonate and function hydrazone were prepared and studied. At the same time, from the corresponding monohydrazones syringaldehyde have been synthesized and tested. Initially, the antioxidant and cytoprotective were determined for all the molecules synthesized. The most effective compounds were then tested further to assess the effects of carbonyl scavengers, radical O2°- and NO° cell systems (in vitro). The results show unambiguously that, for the first time, we have synthesized molecules with both antioxidant and carbonyl scavenger effect. Finally, the in vivo activity of the most active compound, was evaluated. In a second step, Physicochemical studies have been conducted to understand the mode of action of these compounds through three potential activities in conjunction with their antiatherogenic properties. These tests were on: -The ability of the compounds synthesized radical scavenging stable DPPH• and ABTS•+. -The complexing properties of these compounds with respect to the Cu metal. -The inhibitory action of the compound most active with respect to the in vitro production of superoxide anion O2- degrees
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Tirza, Cornelia. "Nouvelles réactions des hydrazones et trialkylalanes." Palaiseau, Ecole polytechnique, 2003. http://www.theses.fr/2003EPXX0017.

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ATLAN, VALERIE. "Nouvelles avancees dans la chimie des hydrazones." Paris 11, 2000. http://www.theses.fr/2000PA112280.

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Ce travail de methodologie intitule : nouvelles avancees dans la chimie des hydrazones est compose de trois chapitres. Le premier presente une nouvelle reaction de cycloaddition 4 + 1 mettant en jeu un azoalcene genere in situ a partir d'une hydrazone -halogenee et un isonitrile. Les 5-aminopyrazoles attendus sont obtenus avec de bons rendements et cette nouvelle methodologie a ete exploitee pour la synthese elegante d'un antihistaminique. Dans un deuxieme chapitre, la recherche d'une alternative a la preparation d'hydrazone -halogenees -substituees nous a conduits a redecouvrir une ancienne reaction de mannich. Cette derniere utilisant les hydrazones comme nucleophiles a ete etendue a tout aldehyde et conduit a la preparation de hydrazones -aminees -substituees avec de bons rendements. Ces dernieres permettent, dans des conditions particulieres (thermiques, acides ou en presence d'un agent alkylant : le 1,2-dibromoethane), de generer in situ un azoalcene piege, notamment, dans des reactions de cycloaddition 4 + 2 et 4 + 1 avec des isonitriles (obtention de 5-aminopyrazoles et de 1,6-, 1,4-dihydropyridazines). Enfin nous avons mis au point une reduction par le zinc de ces bases de mannich conduisant a des -aminoacides. Dans un troisieme chapitre, nous avons elabore une nouvelle synthese d'-hydrazonoesters via des azocetenes, reposant sur la chimie des cetenes. Cette reaction consiste en l'addition electrophile d'un sel de diazonium sur des cetenes genere a partir d'un chlorure d'acide en presence de pyridine suivi d'un piegeage de l'azocetene par l'ethanol. Cette methode est compatible avec bon nombre de substrats. Le piegeage d'azocetenes par differents nucleophiles a conduit, via la formation de nouvelles liaisons carbone-carbone, a des composes heterocycliques.
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Ronsseray, Caroline. "Des isonitriles aux hydrazones : Réactions multicomposants et Synthèses d'hétérocycle." Phd thesis, Palaiseau, Ecole polytechnique, 2011. https://pastel.hal.science/docs/00/66/49/85/PDF/Final2M.pdf.

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Les réactions multicomposants (MCR) permettent l'obtention monotope de molécules cibles à partir de 3 composants ou plus. Cette méthodologie est très utile, notamment dans la synthèse d'hétérocycles. Les isonitriles, de par leur réactivité particulière, sont les réactifs de prédilection pour ces réactions. Dans un premier temps, une nouvelle synthèse d'oxazoles a été mise au point. A partir des réactifs deux réactions sont en compétitions. Cette étude met en évidence l'importance du choix d'une base dans la chimioselectivité d'un processus. Dans un deuxième temps, un travail a été effectué sur les hydrazones. Une nouvelle synthèse d'hydrazones à 3-composants a été mise au point. Cette réaction, couplée à la synthèse de Fischer permet l'obtention d'indoles fonctionnalisés sans isolation d'intermédiaires. De plus, grâce à ces hydrazones, une nouvelle réaction de cyclisation/oxydation catalysée au cuivre (II) a été découverte. Ce couplage permet la synthèse de pyrazolidinones de manière efficace. Cette réaction appliquée à des adduits préparé par la réaction de Ugi, devient une nouvelle voie de post-condensation de ces composés<br>Multicomponent reactions (MCR), as one-pot reactions, are effictient to synthesis target compounds with at least 3-starting materials. This methodology is very useful, in particular for heterocycle synthesis. Isocyanides, due to their specific reactivity, are favorite starting materials for these reactions. In first hand, a new oxazole-synthesis was discovered. Two reactions are in competition, that is why this study further stress the influence of the base on the chemoselectivity of the process. In second hand, research have been made on hydrazones. A new 3-components synthesis was discovered. This reaction coupled with a Fischer synthesis is an efficient way to obtain indole compounds. Moreover, these hydrazones allow us to discover a new reaction of cyclisation/oxidation to form pyrazolidinones. This new reaction applied to product prepared thanks to the Ugi coupling, become a new post-condensation reaction for these compounds
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Simpson, Mark Geoffrey. "Steroid and heterocycle-based macrocyclic N-Acyl hydrazones." Thesis, University of Cambridge, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.621549.

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Torres, Antón Òscar. "New carbocyclisations of polyunsaturated hydrazones catalysed by rhodium(I)." Doctoral thesis, Universitat de Girona, 2017. http://hdl.handle.net/10803/401739.

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Some of the most powerful methods for synthesizing complex organic molecules with high levels of chemo-, diastereo- and enantioselectivity rely on metal carbene chemistry. These compounds are versatile reaction intermediates that can react with a wide variety of functional groups. This doctoral thesis is based on the methodological study of enantioselective rhodium(I) carbene-mediated cascade reactions comprising a carbene/alkyne metathesis step, triggered by base-free decomposition of sulfonylhydrazones. With this methodology, sulfonated azacyclic framerworks, vinylcyclopropane and methylenetetrahydropyran scaffolds have been synthesised in an enantioselective manner<br>Alguns dels mètodes més poderosos emprats per a la síntesi de compostos orgànics amb estructues complexes i amb als nivells de quimio-, diastereo- i enantioselectivitat estan basats en la química dels carbens metàl·lics. Aquests compostos són intermedis de reacció molt versàtils, amb capacitat d’actuar vers una gran varietat de grups funcionals. Aquesta tesi doctoral es basa en l’estudi metodològic de reaccions en cascada enantioselectives a través de metàtesi carbè/alquí, catalitzada per carbens de rodi(I) obtinguts mitjançant la descomposició, en absència de base, de sulfonilhidrazones. Amb aquesta metodologia s'ha aconseguit sintetitzar compostos azacíclics sulfonats, viniciclopropans i metiletetrahidropirà de manera enantioselectiva
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Books on the topic "Hydrazones"

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A, Kogan V., T͡S︡ivadze A. I͡U︡, and Institut obshcheĭ i neorganicheskoĭ khimii im. N.S. Kurnakova., eds. Kompleksy perekhodnykh metallov s gidrazonami: Fiziko-khimicheskie svoĭstva i stroenie. "Nauka", 1990.

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Meiers, Michaela Elisabeth. Diastereo- und enantioselektive Synthese von C2symmetrischen 1,n-Diaminen durch nucleophile 1,2-Addition an Dialdehyd-SAMP-Hydrazone. [s.n.], 1997.

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Poiesz, Christine. Enantioselektive Synthese N-geschützter [alpha]-Aminoketone [alpha-Aminoketone] via elektrophile Aminierung von SAMP-RAMP-Hydrazonen und [alpha]-Silylketonen [alpha-Silylketonen]. [s.n.], 1997.

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Aachen, Rheinisch-Westfälische Technische Hochschule, ed. Enantioselektive Synthese von [alpha]-, [beta]- und [omega]-Aminoacetalen [Omega-Aminoacetalen] und -Aminosäuren durch 1,2-Addition an Aldehyd-SAMP/RAMP-Hydrazone. [s.n.], 1994.

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Knopp, Monika. Diastereo- und enantioselektive Caroll- und Aza-Claisen-Umlagerung mit Hilfe der SAMP, RAMP-Hydrazon-Methode. [s.n.], 1996.

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6

Rendenbach, Beatrice. Asymmetrische Michael-Additionen via SAMP-/RAMP-Hydrazone - diastereo- und enantioselektive Synthese von substituierten 5-Oxoestern [Oxoestern] und d-Lactonen [Delta-Lactonen]. [s.n.], 1987.

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Reinhold, Ulrich. Diastereo- und enantioselektive Synthese von 1,2-Aminoalkoholen und [alpha]-Hydroxyaldehyden [Alpha-Hydroxyaldehyden] aus chiralen Glykolaldehyd-Hydrazonen: Asymmetrische Synthese von (R, R)-Statin. s.n.], 1995.

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Hydrazones [Working Title]. IntechOpen, 2019. http://dx.doi.org/10.5772/intechopen.86724.

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Østergaard, Isabella P. Hydrazones: Uses and Reactions. Nova Science Publishers, Incorporated, 2020.

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Karafiat, Ute. Synthese und Reaktionen von Hydrazid-hydrazonen. 1989.

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Book chapters on the topic "Hydrazones"

1

Boucher, L. J., Karl Koeber, Dieter Tille, Helga Demmer, Helga Köttelwesch, and Edith Schleitzer-Rust. "Complexes with Hydrazones or Related Compounds." In Mn Manganese. Springer Berlin Heidelberg, 1988. http://dx.doi.org/10.1007/978-3-662-08178-5_3.

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Friestad, Gregory K. "Radical Additions to Chiral Hydrazones: Stereoselectivity and Functional Group Compatibility." In Topics in Current Chemistry. Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/128_2011_163.

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Abbaspour Tehrani, K., and N. De Kimpe. "From Hydrazones." In Heteroatom Analogues of Aldehydes and Ketones. Georg Thieme Verlag KG, 2004. http://dx.doi.org/10.1055/sos-sd-027-00298.

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Landais, Y., and J. M. Vincent. "Of Hydrazones." In Ketones. Georg Thieme Verlag KG, 2005. http://dx.doi.org/10.1055/sos-sd-026-00610.

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Blakemore, P. R. "Acyl Hydrazones." In Three Carbon-Heteroatom Bonds: Esters and Lactones; Peroxy Acids and R(CO)OX Compounds; R(CO)X, X=S, Se, Te. Georg Thieme Verlag KG, 2005. http://dx.doi.org/10.1055/sos-sd-021-00901.

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REGITZ, MANFRED, and GERHARD MAAS. "Dehydrogenation of Hydrazones." In Diazo Compounds. Elsevier, 1986. http://dx.doi.org/10.1016/b978-0-12-585840-3.50013-1.

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Ooi, T., and K. Maruoka. "Transformation of Hydrazones." In Compounds of Groups 13 and 2 (Al, Ga, In, Tl, Be...Ba). Georg Thieme Verlag KG, 2004. http://dx.doi.org/10.1055/sos-sd-007-00188.

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Dabdoub, M. J. "Synthesis from Hydrazones." In Heteroatom Analogues of Aldehydes and Ketones. Georg Thieme Verlag KG, 2004. http://dx.doi.org/10.1055/sos-sd-027-00215.

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Kim, S., and J. Y. Yoon. "N-Unsubstituted Hydrazones." In Heteroatom Analogues of Aldehydes and Ketones. Georg Thieme Verlag KG, 2004. http://dx.doi.org/10.1055/sos-sd-027-00577.

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Kim, S., and J. Y. Yoon. "N-Monosubstituted Hydrazones." In Heteroatom Analogues of Aldehydes and Ketones. Georg Thieme Verlag KG, 2004. http://dx.doi.org/10.1055/sos-sd-027-00586.

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Conference papers on the topic "Hydrazones"

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Milenković, Dejan, Marko Antonijević, Edina Avdović, Dušica Simijonović, and Zoran Marković. "Design, in Silico Evaluation, and Toxicological Assessment of $N$-Protocatechoyl Hydrazone Derivatives as Potential EGFR Kinase Inhibitors." In 2024 IEEE 24th International Conference on Bioinformatics and Bioengineering (BIBE). IEEE, 2024. https://doi.org/10.1109/bibe63649.2024.10820446.

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Alegre-Requena, Juan Vicente, Raquel P. Herrera, Isaac G. Sonsona, Eugenia Marqués-López, and M. Concepción Gimeno. "Asymmetric aza-Henry reaction of hydrazones." In The 24th International Electronic Conference on Synthetic Organic Chemistry. MDPI, 2020. http://dx.doi.org/10.3390/ecsoc-24-08411.

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Branković, Jovica, Vesna Milovanović, Zorica D. Petrović, and Vladimir P. Petrović. "GALLIC ACID HYDRAZONES: ‘IN SILICO’ INHIBITION OF THIOREDOXIN REDUCTASE." In 1st INTERNATIONAL Conference on Chemo and BioInformatics. Institute for Information Technologies, University of Kragujevac, 2021. http://dx.doi.org/10.46793/iccbi21.320b.

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Gallic hydrazones, as gallic acid derivatives, are known as pharmacophores of numerous multipotent agents. Among them, antiproliferative activity is one of the most important. On the other hand, thioredoxin reductase (TrxR1) is a part of the thioredoxin system, one of the most important systems responsible for maintaining the redox equilibrium inside the cell. It is overexpressed in different forms of tumors. Bearing this in mind, TrxR1 is a valid target for the development of compounds with potential antiproliferative activity. For this purpose, eight gallic acid-based hydrazones are selected and examined in silico for their potential inhibitory activity towards TrxR1.
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Branković, Jovica, Zorica D. Petrović, and Vladimir P. Petrović. "Phenolic N-acyl hydrazone derivatives: In silico assessment of potential antibacterial activity against selected G+ and G- strains." In 2nd International Conference on Chemo and Bioinformatics. Institute for Information Technologies, University of Kragujevac, 2023. http://dx.doi.org/10.46793/iccbi23.491b.

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In this work, a series of phenolic N-acyl hydrazones was investigated in silico against six selected E. coli and S. aureus bacterial proteins. Generally, the obtained molecular docking results revealed significantly higher binding affinities of analogs a–n towards selected enzymes in comparison to standard compounds. In the case of E. coli proteins 1hnj, 1c14, and 6ntw, the lowest binding energies were calculated for derivatives l (-8.5 kcal/mol), d (-9.0 kcal/mol), and k (-8.2 kcal/mol), respectively. On the other hand, the highest binding affinity towards the S. aureus 3u2d, 1mwu, and 1jij enzymes was expressed by derivatives a, d, and j, with binding energies of -8.3, -8.4, and -9.4 kcal/mol, respectively. The obtained in silico results indicate the potential inhibitory activity of selected phenolic N-acyl hydrazone derivatives against E. coli and S. aureus bacterial proteins and represent a valuable ground base for future in vitro experiments.
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Tien, Vu Dinh, Vu Van Vu, Angela Koeckritz, Trinh Thi Nhung, Do Thi Thao, and Tran Khac Vu. "Novel (-)-gossypol derived hydrazones: Synthesis and biological evaluation." In INTERNATIONAL CONFERENCE ON CHEMICAL ENGINEERING, FOOD AND BIOTECHNOLOGY (ICCFB2017): Proceedings of the 3rd International Conference on Chemical Engineering, Food and Biotechnology. Author(s), 2017. http://dx.doi.org/10.1063/1.5000178.

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Nikolova-Mladenova, Boryana. "Design and Bioactivity Evaluation of Chloro-Substituted Hydrazones." In IECBM 2024. MDPI, 2024. http://dx.doi.org/10.3390/proceedings2024103045.

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Nesterkina, Mariia, Sergii Smola, and Iryna Kravchenko. "Skin permeability and analgesic activity effects of verbenone hydrazones." In 6th International Electronic Conference on Medicinal Chemistry. MDPI, 2020. http://dx.doi.org/10.3390/ecmc2020-07498.

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Hamzi, I. "Synthesis and Characterization of a Series of Chromone–Hydrazones." In ECSOC 2024. MDPI, 2024. https://doi.org/10.3390/ecsoc-28-20131.

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NAKASHIMA, TAKAYASU, TAKASHI YAMADA, HIDEKI HASHIMOTO, and TAKAYOSHI KOBAYASHI. "STRUCTURES AND OPTICAL PROPERTIES OF HYDRAZONES DERIVED FROM BIOLOGICAL POLYENES." In Proceedings of 2000 International Conference. WORLD SCIENTIFIC, 2001. http://dx.doi.org/10.1142/9789812811387_0077.

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Khattar, Tarun, Pilli Govindaiah, Abhijeet Mishra, M. D. Mustafiz Ansari, and Paranjeet Kaur. "A systematic review on hydrazones their chemistry and biological activities." In THE FOURTH SCIENTIFIC CONFERENCE FOR ELECTRICAL ENGINEERING TECHNIQUES RESEARCH (EETR2022). AIP Publishing, 2023. http://dx.doi.org/10.1063/5.0168993.

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