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1

Sun, Zi-Qiang, Shun-Feng Yu, Xin-Lan Xu, Xiao-Yang Qiu, and Shu-Juan Liu. "Two Vanadium(V) Complexes Derived from Bromo and Chloro-Substituted Hydrazone Ligands: Syntheses, Crystal Structures and Antimicrobial Property." Acta Chimica Slovenica 67, no. 4 (2020): 1281–89. http://dx.doi.org/10.17344/acsi.2020.6236.

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Two vanadium(V) complexes derived from the bromo and chloro-substituted hydrazones N’-(4-bromo-2-hydroxybenzylidene)- 2-chlorobenzohydrazide (H2L1) and N’-(3-bromo-5-chloro-2-hydroxybenzylidene)-3-methylbenzohydrazide (H2L2) with the formula [VOL1(OCH3)(CH3OH)] (1) and [VOL2(OCH3)(CH3OH)] (2) were newly synthesized and characterized by IR, UV-Vis and 1H NMR spectroscopy. The structures of H2L1 and the complexes were further confirmed by single crystal X-ray diffraction. Both vanadium complexes are mononuclear, with the metal atoms coordinated by the hydrazone ligands, methanol ligands, and met
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2

Pogonin, Aleksandr E., George A. Gamov, Maksim N. Zavalishin, and Valentin A. Sharnin. "CONFORMATIONAL BEHAVIOR OF HYDRAZONE DERIVED FROM PYRIDOXAL 5’-PHOSPHATE AND ISONIAZID." IZVESTIYA VYSSHIKH UCHEBNYKH ZAVEDENIY KHIMIYA KHIMICHESKAYA TEKHNOLOGIYA 61, no. 12 (2018): 101–7. http://dx.doi.org/10.6060/ivkkt.20186112.5846.

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The hydrazones derived from pyridoxal or pyridoxal 5’-phosphate and heterocyclic hydrazides are of interest due to their potential biological activity and metal sensing properties. These characteristics of hydrazones could be dependent on the conformation equilibria of molecule since the most stable conformer could differ from the one with the highest affinity towards biomolecule or metal ion. In the present contribution, deprotonated hydrazone formed by pyridoxal 5’-phosphate and isoniazid (PLP-INH3-) was studied by means of quantum chemistry. Three rotations leading to eight conformers are p
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3

Ekram Abdullah Basheer, Kalid Matny Al-jaanaby, and Feras Shauki Al-joboury. "Synthesis a Number of Heterocyclic Compounds Derived From Levofloxacin." Tikrit Journal of Pure Science 20, no. 5 (2023): 84–95. http://dx.doi.org/10.25130/tjps.v20i5.1244.

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In this paper, the preparation a number of heterocyclic compounds five membered rings like oxadiazole, imidazolidine, thiozolidine, tetrazole, azetidine 2-on. Hydrazide (1) was synthesized from the reaction of levofloxacin with hydrazine hydrate. Hydrazone compounds (2-9) were synthesized from the reaction (1) with a number of aldehydes, and 3-acetyl-1,3,4-oxadiazol (10-17) was prepared from the reaction of hydrazones (2-9) with acetic anhydride, 5-oxo-2-aryl imadazoldine derivative (18-25) were prepared from the reaction of hydrazone derivatives (2-9) with glycine, while the reaction of hydra
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4

NAKASHIMA, TAKAYASU, TAKASHI YAMADA, HIDEKI HASHIMOTO, and TAKAYOSHI KOBAYASHI. "STRUCTURES AND OPTICAL PROPERTIES OF HYDRAZONES DERIVED FROM BIOLOGICAL POLYENES." International Journal of Modern Physics B 15, no. 28n30 (2001): 3893–96. http://dx.doi.org/10.1142/s0217979201008937.

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A set of hydrazone molecules was derived from a series of biological polyenes that have different polyene chain-lengths with common substituent group of 2,4-dinitrophenylhydrazine. Their structures were determined by high-resolution NMR spectroscopy as well as X-ray crystallography, and their optical properties were investigated by room and low temperature optical absorption spectroscopy. Among the derivatives so far synthesized, the one that has the shortest polyene chain (C13-DNPH) afforded single crystals without inversion symmetry, hence applicable for the second-order nonlinear optical de
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5

Nora, Amer Hussien, Y. Hussien Hyffaa, and H. Abdulrahman Shaymaa. "Predictive biological activity of newly synthesized hydrazone compounds derived from indomethacin." Journal of Wildlife and Biodiversity 7, Special Issue (2023): 391–402. https://doi.org/10.5281/zenodo.10246323.

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New derivatives of hydrazone have been successfully created, specifically 2-(1-(Aryl)-5-methoxy-2-methyl-1H-indol-3-yl)-N'-(2-chlorobenzylidene) acetohydrazide. The transformation of Indomethacin ester into hydrazide was achieved through a reaction with hydrazine hydrate in absolute ethanol, followed by the reaction of the resulting hydrazide with aromatic aldehydes. The structures of these newly synthesized hydrazones were validated through IR, 1HNMR, and 13CNMR analyses. Each compound's energies were optimized by utilizing density functional theory (DFT) for theoretical calculations. By empl
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6

Dammene Debbih, Ouafa, Assia Sid, Rafika Bouchene, Sofiane Bouacida, Wissam Mazouz, and Noureddine Gherraf. "Two hydrazones derived from 1-aryl-3-(p-substituted phenyl)prop-2-en-1-one: synthesis, crystal structure, Hirshfeld surface analysis andin vitrobiological properties." Acta Crystallographica Section C Structural Chemistry 74, no. 6 (2018): 703–14. http://dx.doi.org/10.1107/s2053229618006812.

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Two chalcones were synthesized by the aldolic condensation of enolizable aromatic ketones with substituted benzaldehydes under Claisen–Schmidt reaction conditions and then treated with 2,4-dinitrophenylhydrazine to yield their corresponding hydrazones. The two (E,Z)-2,4-dinitrophenylhydrazone structures, namely (Z)-1-(2,4-dinitrophenyl)-2-[(E)-3-(4-methylphenyl)-1-phenylallylidene]hydrazine, C22H18N4O4, (H1), and (Z)-1-[(E)-3-(4-chlorophenyl)-1-(naphthalen-1-yl)allylidene]-2-(2,4-dinitrophenyl)hydrazine, C25H17ClN4O4, (H2), were isolated by recrystallization and characterized by FT–IR, UV–Vis,
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7

Tisovský, Pavol, Miroslav Horváth, Klaudia Csicsai, et al. "Isatin-1,8-Naphthalimide Hydrazones: A Study of Their Sensor and ON/OFF Functionality." Molecules 24, no. 3 (2019): 397. http://dx.doi.org/10.3390/molecules24030397.

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Five novel hydrazones derived from substituted isatins were synthesized as potential anion sensors. Using UV-VIS, FTIR, NMR and fluorescence spectroscopy, these compounds’ tautomeric equilibrium and Z-E photoisomerization were studied in DMF and CHCl3, depending on the hydrazone concentrations, the presence of basic anions and light stimulation. Anion recognition aspects (PF6−, HSO4−, Br−, Cl−, NO3−, F− and CH3COO−) and these receptors’ detection limits were also studied. We also tested the light-stimulated ON-OFF functionality of these compounds in the presence or absence of these anions.
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8

Xu, Xiaoyan, Jun Zhang, Hongguang Xia, and Jie Wu. "C(sp2)–H functionalization of aldehyde-derived hydrazones via a radical process." Organic & Biomolecular Chemistry 16, no. 8 (2018): 1227–41. http://dx.doi.org/10.1039/c8ob00056e.

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This review is focused on the recent advances in the C(sp<sup>2</sup>)–H functionalization of aldehyde-derived hydrazones via a radical process. Diverse substituted hydrazones including N-heterocycles are afforded under mild conditions with excellent selectivities. In general, an aminyl radical as the key intermediate is involved during the reaction process.
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9

Rodina, Liudmila L., Xenia V. Azarova, Jury J. Medvedev, Dmitrij V. Semenok, and Valerij A. Nikolaev. "Novel photochemical reactions of carbocyclic diazodiketones without elimination of nitrogen – a suitable way to N-hydrazonation of C–H-bonds." Beilstein Journal of Organic Chemistry 14 (August 28, 2018): 2250–58. http://dx.doi.org/10.3762/bjoc.14.200.

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The sensitized photoexcitation of 2-diazocyclopentane-1,3-diones in the presence of THF leads to the insertion of the terminal N-atom of the diazo group into the α-С–Н bond of THF, producing the associated N-alkylhydrazones in yields of up to 63–71%. Further irradiation of hydrazones derived from furan-fused tricyclic diazocyclopentanediones culminates in the cycloelimination of furans to yield 2-N-(alkyl)hydrazone of cyclopentene-1,2,3-trione. By contrast, the direct photolysis of carbocyclic diazodiketones gives only Wolff rearrangement products with up to 90–97% yield.
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10

Wang, Fu-Ming, Li-Jie Li, Guo-Wei Zang, Tong-Tong Deng, and Zhong-Lu You. "Synthesis, Characterization, Crystal Structures, and Urease Inhibition of Copper(II) and Zinc(II) Complexes Derived from Benzohydrazones." Acta Chimica Slovenica 67, no. 4 (2020): 1155–62. http://dx.doi.org/10.17344/acsi.2020.6056.

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A new copper(II) complex [Cu(L1)(NCS)(CH3OH)] (1) and a new zinc(II) complex [ZnCl2(HL2)] · CH3OH (2), derived from 4-bromo-N’-(pyridin-2-ylmethylene)benzohydrazide (HL1) and 4-methoxy-N’-(pyridin-2-ylmethylene)benzohydrazide (HL2), were prepared and characterized by elemental analysis, IR and UV-Vis spectroscopy and single crystal X-ray diffraction. The hydrazone HL1 coordinates to the Cu atom in enolate form, while the hydrazone HL2 coordinates to the Zn atom in carbonyl form. Single crystal structural analyses indicate that the hydrazones coordinate to the metal atoms through the pyridine N
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11

Claraz, Aurélie. "Harnessing the versatility of hydrazones through electrosynthetic oxidative transformations." Beilstein Journal of Organic Chemistry 20 (August 14, 2024): 1988–2004. http://dx.doi.org/10.3762/bjoc.20.175.

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Hydrazones are important structural motifs in organic synthesis, providing a useful molecular platform for the construction of valuable compounds. Electrooxidative transformations of hydrazones constitute an attractive opportunity to take advantage of the versatility of these reagents. By directly harnessing the electrical current to perform the oxidative process, a large panel of organic molecules can be accessed from readily available hydrazones under mild, safe and oxidant-free reaction conditions. This review presents a comprehensive overview of oxidative electrosynthetic transformations o
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12

Abdullah, Shaima H., Bushra A. Khairallah, and Khalid A. Al-Badrany. "Preparation and characterization of some azetidine-2-one derivatives derived from benzothiazole-2-ol and evaluation of their biological activity." INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY 35, no. 01 (2025): 37. https://doi.org/10.59467/ijhc.2025.35.37.

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This study involves the use of hydrazones derived from 2-hydroxybenzothiazole as nucleophiles to prepare several heterocyclic azetidine derivatives by reacting the prepared hydrazone with chloroacetyl chloride. Dioxane was used as a solvent, and triethylamine was used as a catalyst. In addition to determining the melting point, the structures of the prepared compounds were confirmed by physical and spectroscopic methods, infrared, proton, and carbon nuclear magnetic resonance (1H and 13C-NMR) spectroscopy, and thin layer chromatography to track the reaction progress. The biological viability w
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13

Kuranova, Natalia N., Oleg A. Pimenov, Maksim N. Zavalishin, and George A. Gamov. "Complexes of Gold(III) with Hydrazones Derived from Pyridoxal: Stability, Structure, and Nature of UV-Vis Spectra." International Journal of Molecular Sciences 25, no. 9 (2024): 5046. http://dx.doi.org/10.3390/ijms25095046.

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Pyridoxal and pyridoxal 5′-phosphate are aldehyde forms of B6 vitamin that can easily be transformed into each other in the living organism. The presence of a phosphate group, however, provides the related compounds (e.g., hydrazones) with better solubility in water. In addition, the phosphate group may sometimes act as a binding center for metal ions. In particular, a phosphate group can be a strong ligand for a gold(III) ion, which is of interest for researchers for the anti-tumor and antimicrobial potential of gold(III). This paper aims to answer whether the phosphate group is involved in t
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14

Epishina, Margarita A., Alexander S. Kulikov, and Leonid L. Fershtat. "4-Amino-3-(1-{[amino(3-methyl-2-oxido-1,2,5-oxadiazol-4-yl)methylene]hydrazinylidene}ethyl)-1,2,5-oxadiazole 2-Oxide." Molbank 2022, no. 3 (2022): M1425. http://dx.doi.org/10.3390/m1425.

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Functionally substituted 1,2,5-oxadiazole 2-oxides (furoxans) are important pharmaceutical scaffolds used for the preparation of various pharmacologically active substances. Furoxans bearing hydrazone functionality are considered as promising drug candidates for the treatment of neglected diseases. However, pharmacologically oriented hydrazones derived from (furoxanyl)amidrazones and acetylfuroxans have remained unknown so far. In this communication, a simple method for the synthesis of 4-amino-3-(1-{[amino(3-methyl-2-oxido-1,2,5-oxadiazol-4-yl)methylene]hydrazinylidene}ethyl)-1,2,5-oxadiazole
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15

Palanimuthu, Duraippandi, Zhixuan Wu, Patric J. Jansson, et al. "Novel chelators based on adamantane-derived semicarbazones and hydrazones that target multiple hallmarks of Alzheimer's disease." Dalton Transactions 47, no. 21 (2018): 7190–205. http://dx.doi.org/10.1039/c8dt01099d.

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16

Sulaiman, Ahmed T., and Susan W. Sarsam. "Synthesis, Characterization and Antibacterial Activity Evaluation of New Indole-Based Derivatives." Iraqi Journal of Pharmaceutical Sciences ( P-ISSN: 1683 - 3597 , E-ISSN : 2521 - 3512) 29, no. 1 (2020): 207–2015. http://dx.doi.org/10.31351/vol29iss1pp207-2015.

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A new series of N-acyl hydrazones (4a-g) derived from indole-3-propionic acid (IPA) were synthesized. These N-acyl hydrazones were prepared by the reaction of 3-(1H-indol-3-yl) propane hydrazide and aldehyde in the existence of glacial acetic acid as a catalyst. 1HNMR and FT-IR analyses were used to identify the synthesized compounds and they were in vitro evaluated as antibacterial agents against six different types of microorganisms by using well diffusion method. All the tested N-acyl hydrazones (4a-g) displayed moderate activity against the Gram-negative E.coli, comparable to that of Amoxi
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17

Pallapati, Ramya Krishna, Baby Ramana Mutchu, Umamaheswara Rao Vanga, Ravi Varala, and Hari Babu Bollikolla. "Synthesis, Characterization and Antioxidant Activity of Some New 3-(3-(Trifluoromethyl)phenyl)acrylic Acid Derived Hydrazide-Hydrazone Scaffolds." Asian Journal of Chemistry 32, no. 8 (2020): 2099–104. http://dx.doi.org/10.14233/ajchem.2020.22825.

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Some new analogues of trifluoromethylphenyl acrylic acid scaffold derived hydrazide-hydrazones (4a-l) were produced by using various structurally divergent aromatic aldehydes. All the hydrazones were obtained in moderate to good yields (64-78%) in methanol at a temperature of 45-65 °C. All the compounds were screened for antioxidant activity by DPPH method and the compounds 4c, 4d, 4e and 4h were found to be showed maximum antioxidant activity among the synthesized compounds.
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18

Volkova, Yulia A., Elena I. Chernoburova, Albina S. Petrova, Alexander A. Shtil, and Igor V. Zavarzin. "Reactions of hydrazones derived from oxamic acid thiohydrazides." Phosphorus, Sulfur, and Silicon and the Related Elements 192, no. 2 (2016): 237–40. http://dx.doi.org/10.1080/10426507.2016.1250759.

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19

Digambar, Dr Kokane Balaji. "Facile Synthesis Of 1H-Indazoles Through IodobenzeneCatalyzed C–H Amination Under Mild And Metal-Free Conditions." IOSR Journal of Applied Chemistry 18, no. 1 (2025): 01–03. https://doi.org/10.9790/5736-1801010103.

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The transition-metal- and halogen-free synthesis of N-aryl substituted 1H-indazole and derivatives was accomplished on the basis of the iodobenzene-catalyzed intramolecular C -H amination of hydrazones under mild conditions. Reactions of hydrazones derived from ketones and hydrazines with a catalytic amount of iodobenzene in the presence of Oxone as an oxidant in trifluoroacetic acid took place to afford 1H indazoles in moderate to good yields.
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20

Nesterkina, Mariia, Dmytro Barbalat, and Iryna Kravchenko. "Design, synthesis and pharmacological profile of (−)-verbenone hydrazones." Open Chemistry 18, no. 1 (2020): 943–50. http://dx.doi.org/10.1515/chem-2020-0103.

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AbstractA series of novel (−)-verbenone hydrazones was designed and synthesized via condensation of terpenoid with hydrazides derived from phenoxyacetic acid. The structure of target compounds was confirmed by 1H-NMR and 13C-NMR analysis, Raman and FT-IR spectroscopy, electrospray ionization method and fast atom bombardment (FAB) mass spectrometry. Thermal properties of (−)-verbenone hydrazones 3a–3e were estimated by differential scanning calorimetry and their purity by HPLC coupled to mass spectrometry. Verbenone hydrazones were revealed to exist as Z/E geometrical isomers about C═N bond and
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21

ASIRI, A., I. ISMAIL, K. ALAMRY, and N. FATANI. "Novel dyes derived from hydrazones. Part 2: synthesis and characterizations of -methyl-4-tricyanovinylidenephenyl-hydrazones." Dyes and Pigments 67, no. 2 (2005): 111–15. http://dx.doi.org/10.1016/j.dyepig.2004.10.010.

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22

MRIDULA, VERMA, and M. VERMA SHIVA. "Hydrogen Bonding and the Stereochemistry of Hydrazones and Hydrazides derived from 1,3-Dicarbonyl Compounds involving Imino Nitrogen." Journal of Indian Chemical Society Vol. 69, Sep 1992 (1992): 561–62. https://doi.org/10.5281/zenodo.6006453.

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Department of Chemistry, Banaras Hindu University, Varanasi-221 005 <em>Manuscript received 5 August 1991, revised 8 June 1992, accepted 3 July 1992</em> <em>&beta;</em>-Diketones form hydrazones with <em>N&#39; ,N&#39;</em> -diacylhydrazines and exhibit a six-membered hydrogen bonded cyclic ketiminyl system involving the imino nitrogen. <sup>1</sup>H nmr spectra of the hydrazones obtained from <em>N</em>-amino -&alpha;, &beta;- (9,10-dihydroanthracene-9,10-endo-diyl)succinimide and acetylacetone demonstrated restricted rotation about <em>N-N</em> bond and a planer hydrogen bonded cyclic syste
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23

Pimenov, Oleg A., Konstantin V. Grazhdan, Maksim N. Zavalishin, and George A. Gamov. "Geometry and UV-Vis Spectra of Au3+ Complexes with Hydrazones Derived from Pyridoxal 5′-Phosphate: A DFT Study." International Journal of Molecular Sciences 24, no. 9 (2023): 8412. http://dx.doi.org/10.3390/ijms24098412.

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Gold(III) complexes with different ligands can provide researchers with a measure against pathogenic microorganisms with antibiotic resistance. We reported in our previous paper that the UV-Vis spectra of different protonated species of complexes formed by gold(III) and five hydrazones derived from pyridoxal 5′-phosphate are similar to each other and to the spectra of free protonated hydrazones. The present paper focuses on the reasons of the noted similarity in electron absorption spectra. The geometry of different protonated species of complexes of gold(III) and hydrazones (15 structures in
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24

Ano, Yusuke, Masaya Higashino, Yuki Yamada, and Naoto Chatani. "Palladium-catalyzed synthesis of nitriles from N-phthaloyl hydrazones." Chemical Communications 58, no. 23 (2022): 3799–802. http://dx.doi.org/10.1039/d2cc00342b.

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25

Kumara, H. K., R. Suhas, D. M. Suyoga Vardhan, M. Shobha, and D. Channe Gowda. "A correlation study of biological activity and molecular docking of Asp and Glu linked bis-hydrazones of quinazolinones." RSC Advances 8, no. 19 (2018): 10644–53. http://dx.doi.org/10.1039/c8ra00531a.

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26

Basiony, Ebtesam A., Allam A. Hassan, Zahra M. Al-Amshany, et al. "Synthesis and Cytotoxic Activity of New Thiazolopyrimidine Sugar Hydrazones and Their Derived Acyclic Nucleoside Analogues." Molecules 25, no. 2 (2020): 399. http://dx.doi.org/10.3390/molecules25020399.

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New thienyl- or chlorophenyl-substituted thiazolopyrimidine derivatives and their derived sugar hydrazones incorporating acyclic d-galactosyl or d-xylosyl sugar moieties in addition to their per-O-acetylated derivatives were synthesized. Heterocyclization of the formed sugar hydrazones afforded the derived acyclic nucleoside analogues possessing the 1,3,4-oxadiazoline as modified nucleobase via acetylation followed by the cyclization process. The cytotoxic activity of the synthesized compounds was studied against human breast cancer MCF7 and MDA-MB-231 cell lines as well as human colorectal ca
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27

Zhu, Xin, Zhi He, Qiu-Yan Li, and Xiao-Jun Wang. "Direct C(sp2)–H amination of aryl aldehyde-derived hydrazones via visible light promoted photoredox catalysis." RSC Advances 7, no. 40 (2017): 25171–74. http://dx.doi.org/10.1039/c7ra01229b.

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28

Kalpana, Chaturvedi. "Novel Synthesis of Some Organophosphorus Derivatives as Chemotherapeutants against Fungal Pathogens of Sugracane." Der Pharma Chemica 14, no. 2 (2022): 7. https://doi.org/10.4172/0975-413X.14.2. 16-22.

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The reactions of O,O-diethylchlorophosphate or O,O-diethylchlorothiophosphate with 1,4-phthalazine-bis(hydrazones), derived by the condensation of 1,4-dihydrazinophthalazine dihydrochloride monohydrate and 2-hydroxy benzaldehyde/4-hydroxy benzaldehyde/2- hydroxyacetophenone/4-hydroxyacetophenone, have been studied and a variety of organophosphorus derivatives have been obtained. The derivatives have been characterized on the basis of analyses and spectral (IR, 1H NMR) data and tested for their antifungal efficacy against colletotrichum falcatum, Fusarium oxysporum and Curvularia pallescens (al
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29

Chaturvedi, Kalpana, and Smita Chaturvedi. "Novel Synthesis of Some Organophosphorus Derivatives as Chemotherapeutants against Fungal Pathogens of Sugracane." Der Pharma Chemica 14, no. 2 (2022): 7. https://doi.org/10.5281/zenodo.13354182.

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The reactions of O,O-diethylchlorophosphate or O,O-diethylchlorothiophosphate with 1,4-phthalazine-bis(hydrazones), derived by the condensation of 1,4-dihydrazinophthalazine dihydrochloride monohydrate and 2-hydroxy benzaldehyde/4-hydroxy benzaldehyde/2- hydroxyacetophenone/4-hydroxyacetophenone, have been studied and a variety of organophosphorus derivatives have been obtained. The derivatives have been characterized on the basis of analyses and spectral (IR, 1H NMR) data and tested for their antifungal efficacy against colletotrichum falcatum, Fusarium oxysporum and Curvularia pallescens (al
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30

Satyender, Apuri, and Doo Ok Jang. "Highly Diastereoselective Indium-Mediated Allylation of Proline-Derived Hydrazones." Bulletin of the Korean Chemical Society 34, no. 9 (2013): 2571–72. http://dx.doi.org/10.5012/bkcs.2013.34.9.2571.

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31

TOK, Fatih, Nagihan BEYHAN, Yalçın ERZURUMLU, Recep İLHAN, Petek BALLAR, and Bedia KOÇYİĞİT KAYMAKÇIOĞLU. "Antiproliferative activity of some tautomeric hydrazones derived from chalcones." MARMARA PHARMACEUTCAL JOURNAL 20, no. 2 (2016): 157. http://dx.doi.org/10.12991/mpj.20162093956.

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32

Easmon, J., H. Frunicke, G. Heinisch, J. Hofmann, and G. Pürstinger. "Novel diazine derived hydrazones as potential ribonucleotide reductase inhibitors." Journal of Cancer Research and Clinical Oncology 121, S1 (1995): S38. http://dx.doi.org/10.1007/bf02559903.

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33

Łukasik, Beata, Justyna Kowalska, Sebastian Frankowski, and Łukasz Albrecht. "Vinylogous hydrazone strategy for the organocatalytic alkylation of heteroaromatic derivatives." Chemical Communications 57, no. 51 (2021): 6312–15. http://dx.doi.org/10.1039/d1cc01923f.

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A new umpolung approach for the asymmetric Friedel–Crafts-type alkylation of electron-poor heteroaromatic systems has been developed. It is based on the vinylogous reactivity of hydrazones derived from heteroaromatic aldehydes.
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34

Liu, Jialin, Jilei Cao, Rongfang Liu, Ruifeng Li, Yan Qiao, and Rong Zhou. "Condensation of 1,2-dicarbonyl compounds with modified Huisgen zwitterions: synthesis of N-aryl–N-acyl hydrazones." Organic & Biomolecular Chemistry 18, no. 3 (2020): 530–37. http://dx.doi.org/10.1039/c9ob02508a.

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The reactivity patterns of the modified Huisgen zwitterions derived from arylazocarboxylates toward 1,2-dicarbonyl compounds have been studied for the first time for a facile synthesis of N-aryl–N-acyl hydrazones.
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35

Velázquez, Marta, Saúl Alberca, Javier Iglesias-Sigüenza, Rosario Fernández, José M. Lassaletta та David Monge. "Catalytic enantioselective synthesis of α-aryl α-hydrazino esters and amides". Chemical Communications 56, № 43 (2020): 5823–26. http://dx.doi.org/10.1039/d0cc02478c.

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Asymmetric 1,2-addition of aryl boronic acids to N-carbamoyl (Cbz and Fmoc) protected glyoxylate-derived hydrazones affords α-aryl α-hydrazino esters/amides, key building blocks en route to artificial peptides.
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36

Jia, Wen-Qiang, Han-Ming Zhang, Chun-Lin Zhang, Zhong-Hua Gao та Song Ye. "N-Heterocyclic carbene-catalyzed [4 + 2] annulation of α,β-unsaturated carboxylic acids: enantioselective synthesis of dihydropyridinones and spirocyclic oxindolodihydropyridinones". Organic Chemistry Frontiers 3, № 1 (2016): 77–81. http://dx.doi.org/10.1039/c5qo00301f.

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The N-heterocyclic carbene-catalyzed [4 + 2] annulation of α,β-unsaturated carboxylic acid with hydrazones and isatin-derived imines was developed, affording the corresponding dihydropyridinones, respectively, in good yields with high enantioselectivities.
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37

Uozumi, Yasuhiro, Takao Osako, Makoto Nagaosa, and Go Hamasaka. "Asymmetric Copper-Catalyzed C(sp)–H Bond Insertion of Carbenoids Derived from N-Tosylhydrazones." Synlett 29, no. 17 (2018): 2251–56. http://dx.doi.org/10.1055/s-0037-1611003.

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A chiral copper(I)–phosphoramidite complex efficiently catalyzed the asymmetric insertion of the carbenoids derived from N-tosyl hydrazones into alkyne C–H bonds to give the corresponding chiral alkynylated products in up to 77% yield and with up to 74% ee.
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38

Brecknell, DJ, RM Carman, and RC Schumann. "Kinetic v. Thermodynamic Effects During a Wolff-Kishner Reduction." Australian Journal of Chemistry 42, no. 4 (1989): 527. http://dx.doi.org/10.1071/ch9890527.

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A Wolff-Kishner reduction is discussed which leads to kinetic products through reduction of hydrazones derived from thermodynamically less-stable ketones of an equilibrium mixture. The syntheses and conformational analyses of a range of 9-substituted 2,3,6,7-tetramethyldecahydroanthracenes are discussed.
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39

Mague, J. T., S. Vang, D. G. Berge, and W. F. Wacholtz. "Isomerism/Tautomerism in Hydrazones Derived from Thiophenaldehydes and 2-Hydrazinoquinoline." Acta Crystallographica Section C Crystal Structure Communications 53, no. 7 (1997): 973–79. http://dx.doi.org/10.1107/s0108270197001212.

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40

Dilek, Ozlem, and Susan L. Bane. "Synthesis and Spectroscopic Characterization of Fluorescent Boron Dipyrromethene-Derived Hydrazones." Journal of Fluorescence 21, no. 1 (2010): 347–54. http://dx.doi.org/10.1007/s10895-010-0723-0.

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41

Koçyiğit-Kaymakçıoğlu, Bedia, Emine Elçin Oruç-Emre, Seda Unsalan, and Sevim Rollas. "Antituberculosis activity of hydrazones derived from 4-fluorobenzoic acid hydrazide." Medicinal Chemistry Research 18, no. 4 (2008): 277–86. http://dx.doi.org/10.1007/s00044-008-9126-z.

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42

Tsitsa, P., A. Psarrea-Sandris, and C. Sandris. "Synthesis of hydrazones derived from 2-substituted-10-carboxyphenothiazine hydrazides." Journal of Heterocyclic Chemistry 24, no. 6 (1987): 1661–63. http://dx.doi.org/10.1002/jhet.5570240632.

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43

Hamilton, Gregory, and Patience Mukashyaka. "A Fluorenyl Activating Group Enables Addition of Simple Grignard Reagents to C=N Electrophiles." Synlett 29, no. 14 (2018): 1857–60. http://dx.doi.org/10.1055/s-0037-1609551.

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Nucleophilic addition of organometallic reagents to ketimines and hydrazones can be a challenging transformation. Here we report the use of fluorenone-derived mixed azines which promote facile addition of Grignard reagents. The fluorenylidene activating group is easily installed and removed, thereby offering practical access to highly substituted amines and hydrazines.
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44

Riya, Datta, R. Sunaja Devi K., and B. Sreeja P. "Synthesis, spectral characterization and antimicrobial studies of novel acyl hydrazones of p-acetoxybenzaldehyde." Journal of Indian Chemical Society Vol. 92, Jun 2015 (2015): 967–69. https://doi.org/10.5281/zenodo.5674319.

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Department of Chemistry, Christ University, Bangalore-560 029, India <em>E-mail </em>: riya.datta@christuniversity.in Novel acyl hydrazones derived from <em>p</em>-acetoxybenzaldehyde and various acid hydrazides have been synthesized. Synthetic procedure is simple and convenient and affords good yield. Elemental analysis and spectral results of the products are also reported.
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45

Attanasi, Orazio A., Lucia De Crescentini, Paolino Filippone, Elisabetta Foresti, and Fabio Mantellini. "2-Oxohydrazones, 4-Hydrazono-1H-pyrazol-5-ones, and Derived Products by Air Oxidation of 1,2-Hydrazino-hydrazones." Journal of Organic Chemistry 65, no. 9 (2000): 2820–23. http://dx.doi.org/10.1021/jo9917792.

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46

Alsalim, Tahseen Abdul Qader, Hussain Ali Mzban, and Einas Nasir Abood. "Synthesis and antioxidant study of new hydrazones derived from bisdemethoxycurcumin pyrazole." European Journal of Chemistry 8, no. 4 (2017): 344–48. http://dx.doi.org/10.5155/eurjchem.8.4.344-348.1630.

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47

HAN, Muhammed İhsan, Güler GÜROL, Temel YILDIRM, Sadık KALAYCI, and Fikrettin ŞAHİN. "Synthesis and antibacterial activity of hnew hydrazide-hydrazones derived from Benzocaine." Marmara Pharmaceutical Journal 21, no. 4 (2017): 961–66. http://dx.doi.org/10.12991/mpj.2017.34.

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48

Despaigne, Angel A. Recio, Jeferson G. da Silva, Ana Cerúlia M. do Carmo, et al. "Copper(II) and zinc(II) complexes with 2-formylpyridine-derived hydrazones." Polyhedron 28, no. 17 (2009): 3797–803. http://dx.doi.org/10.1016/j.poly.2009.07.059.

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Denmark, Scott E., James P. Edwards, Theodor Weber, and David W. Piotrowski. "Organocerium additions to proline-derived hydrazones: synthesis of enantiomerically enriched amines." Tetrahedron: Asymmetry 21, no. 9-10 (2010): 1278–302. http://dx.doi.org/10.1016/j.tetasy.2010.04.042.

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Krátký, Martin, Szilvia Bősze, Zsuzsa Baranyai, Jiřina Stolaříková, and Jarmila Vinšová. "Synthesis and biological evolution of hydrazones derived from 4-(trifluoromethyl)benzohydrazide." Bioorganic & Medicinal Chemistry Letters 27, no. 23 (2017): 5185–89. http://dx.doi.org/10.1016/j.bmcl.2017.10.050.

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