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Journal articles on the topic 'Hydrazones'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 July 2025

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1

Ji, Heng, Hui-qiong Ni, Peng Zhi, et al. "Visible-light mediated directed perfluoroalkylation of hydrazones." Organic & Biomolecular Chemistry 15, no. 28 (2017): 6014–23. http://dx.doi.org/10.1039/c7ob01144j.

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A convenient and efficient protocol was reported to access a series of perfluoroalkylated aromatic aldehyde hydrazones. Aliphatic aldehyde hydrazones and N-monosubstituted hydrazones which are unreactive in previously reported hydrazone perfluoroalkylation reactions now take part in the reaction.

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2

KushalNath Mishra, Shambaditya Goswami, Kumudhavalli M.V, et al. "Hydrazones and their metal complexes: A short review on their biological potentia." International Journal of Research in Pharmaceutical Sciences 11, SPL4 (2020): 1440–47. http://dx.doi.org/10.26452/ijrps.v11ispl4.4319.

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Hydrazones belong to complexes are beneficial in different fields for their essential role in the development of a range of stable complexes in the coordination chemistry. Different researchers have reported the various medicinal properties of hydrazones. Hydrazone and its metal complexes are useful for the detection of some organic components from pharmaceutical formulations. These metallic compounds act as a catalyst for conducting various chemical reactions and help in making different chemical complexes that are effective against bacteria, fungi, and many other microbes. Aromatic hydrazone

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3

Asif, Mohammad, and Asif Husain. "Analgesic, Anti-Inflammatory, and Antiplatelet Profile of Hydrazones Containing Synthetic Molecules." Journal of Applied Chemistry 2013 (December 17, 2013): 1–7. http://dx.doi.org/10.1155/2013/247203.

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Hydrazones are present in many of the bioactive compounds with wide interest because of their diverse pharmacological applications. Hydrazones possess wide variety of biological activities such as anticonvulsant, antidepressant, analgesic, anti-inflammatory, antiplatelet, antimicrobial, anticancer, antihypertensive, anthelmintic, antidiabetic, antiparasitic, and other anticipated activities. This created an interest for researchers towards synthesized variety of hydrazone derivatives for different biological activities. Therefore many researchers have synthesized hydrazone derivatives as targe

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4

Kajal, Anu, Suman Bala, Neha Sharma, Sunil Kamboj, and Vipin Saini. "Therapeutic Potential of Hydrazones as Anti-Inflammatory Agents." International Journal of Medicinal Chemistry 2014 (March 4, 2014): 1–11. http://dx.doi.org/10.1155/2014/761030.

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Hydrazones are a special class of organic compounds in the Schiff base family. Hydrazones constitute a versatile compound of organic class having basic structure (R1R2C=NNR3R4). The active centers of hydrazone, that is, carbon and nitrogen, are mainly responsible for the physical and chemical properties of the hydrazones and, due to the reactivity toward electrophiles and nucleophiles, hydrazones are used for the synthesis of organic compound such as heterocyclic compounds with a variety of biological activities. Hydrazones and their derivatives are known to exhibit a wide range of interesting

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5

Šandrik, Róbert, Pavol Tisovský, Klaudia Csicsai, et al. "ON/OFF Photostimulation of Isatin Bipyridyl Hydrazones: Photochemical and Spectral Study." Molecules 24, no. 14 (2019): 2668. http://dx.doi.org/10.3390/molecules24142668.

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Four novel isatin hydrazones containing bipyridyl fragments were synthesized as potential ON/OFF switches. Hydrazone Z-isomers exhibit high thermal stability. The characteristic photochemical reaction for all studied hydrazones is the Z–E isomerization in CHCl3. After irradiation of hydrazones 1 and 2 in dimethylformamide (DMF), the photoreaction products are tautomers. When using light with the appropriate wavelength, the photo-tautomerization reaction is reversible. In these conditions, studied hydrazones have ON/OFF switch properties. In the case of hydrazones 1 and 2, by alternating heat a

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6

Jollimore, Jason V., Marc Vacheresse, Keith Vaughan, and Donald L. Hooper. "The effect of ortho and para substituents on the formation of the E and Z isomers of the arylhydrazones obtained from diazonium coupling with methyl 3-aminocrotonate and 3-aminocrotononitrile." Canadian Journal of Chemistry 74, no. 2 (1996): 254–62. http://dx.doi.org/10.1139/v96-029.

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Reaction of arene diazonium salts with 3-aminocrotononitrile or methyl 3-aminocrotonate affords the 2-aryl-hydrazono-3-oxobutanenitrile (1 or 3 and 3′) or the methyl 2-arylhydrazono-3-oxobutanoate (2 and 2′ or 4 and 4′). A series of these hydrazones has been prepared with a range of electron-withdrawing and -donating substituents in the ortho or para position of the aryl moiety. The hydrazones have been characterized by spectroscopic methods, with emphasis on the 1H NMR spectra, which have been used to determine the configuration of the hydrazones as E or Z or a mixture of the two. The para-su

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7

Sihag, Monika, and Rinku Soni. "HTIB as an Efficient and Convenient Reagent for Oxidative Cleavage of C=N in Pyrimidinyl Hydrazones." Indian Journal of Heterocyclic Chemistry 33, no. 04 (2023): 393. http://dx.doi.org/10.59467/ijhc.2023.33.393.

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This study is aimed to explore the efficiency of [hydroxy(tosyloxy)iodo]benzene (HTIB) in the oxidative cleavage of some pyrimidinyl hydrazones. The protocol involves stirring the hydrazone derivatives with HTIB in dichloromethane at room temperature. The oxidative cleavage of C = N in pyrimidinyl hydrazones regenerated parent ketones in high yields. The methodology has advantage of preventing over oxidation of carbonyl functionality.

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8

Wahbeh, Jenna, and Sarah Milkowski. "The Use of Hydrazones for Biomedical Applications." SLAS TECHNOLOGY: Translating Life Sciences Innovation 24, no. 2 (2019): 161–68. http://dx.doi.org/10.1177/2472630318822713.

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The use of hydrazones presents an opportunity for enhancing drug delivery through site-specific drug release, including areas such as tumor tissue or thrombosis. Many researchers are experimenting on how to more efficiently form these hydrazones, specifically using heat and chemical catalysts. Hydrazones respond on the pH environment or are synthesized with particular functional groups of the hydrazone and are two of the many unique features that allow for their programmed drug release. Their flexibility allows them to be relevant in a diverse range of applications, from anti-inflammatory to a

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9

Rajeev, Jain, Padmaja P., Gupta S., and Gupta Seema. "Electrochemical investigations on some hydrazones." Journal of Indian Chemical Society Vol. 77, Feb 2000 (2000): 91–93. https://doi.org/10.5281/zenodo.5862703.

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School of Studies in Chemistry, Jiwaji University, Gwalior-474 011, India <em>Manuscript received 10 November 1998, revised 2 August 1999, accepted 13 August 1999</em> The electrochemical behaviour of 3-(4'-sulphonamoyl)hydrazono-4-phenylaminobutane-2,4-drones has been studied over a wide pH range at dropping mercury and glassy carbon electrodes. These aryl hydrazones give one four-electron wave/peak corresponding to the reduction of hydrazono group. The wave/peak is found to be diffusion-controlled and irreversible in nature. A reduction mechanism is suggested for the aryl hydra

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10

Pisk, Jana, Ivica Đilović, Tomica Hrenar, Danijela Cvijanović, Gordana Pavlović, and Višnja Vrdoljak. "Effective methods for the synthesis of hydrazones, quinazolines, and Schiff bases: reaction monitoring using a chemometric approach." RSC Advances 10, no. 63 (2020): 38566–77. http://dx.doi.org/10.1039/d0ra06845d.

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11

Patra, Debashis, Subhabrata Paul, Indira Majumder та ін. "Exploring the effect of substituent in the hydrazone ligand of a family of μ-oxidodivanadium(v) hydrazone complexes on structure, DNA binding and anticancer activity". Dalton Transactions 46, № 46 (2017): 16276–93. http://dx.doi.org/10.1039/c7dt03585c.

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12

Fazylov, S., O. Nurkenov, I. Pustolaikina, et al. "CLATHRATE COMPLEXES OF HYDRAZONES OF 2- AND 4-HYDROXYBENZOIC ACIDS WITH CYCLODEXTRINS AND THEIR PROPERTIES." Chemical Journal of Kazakhstan, no. 1 (March 27, 2025): 25–36. https://doi.org/10.51580/2025-1.2710-1185.03.

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The paper presents the results of a study on the preparation of water-soluble complexes of inclusions of 4- and 2-hydroxyhydrazides of benzoic acid and their hydrazones with cyclodextrins (β-CD, γ-CD) in an aqueous alcohol solution. Methods. The complexation of the obtained hydrazones with --, -, -cyclodextrins was studied in silico using molecular docking and modeling methods. Results and discussion. All the investigated hydrazones demonstrated the best value of binding affinity with β -cyclodextrin. The efficiency of binding of the studied hydrazones to cyclodectrins is provided primarily

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13

Kpoviessi, Bénédicta Kpadonou, Bardieu Atchadé, Basile Goueti, et al. "Synthesis, Spectrometrical Characterization and Pharmacological Properties of Six Substituted Hydrazones with Carbonyl Compounds." Chemical Science International Journal 34, no. 2 (2025): 11–24. https://doi.org/10.9734/csji/2025/v34i2953.

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Hydrazones are molecules that prevent the growth of several microbial and parasitic strains by inhibited the replication of DNA sequences due to their chelating properties of metal ions. They are well recognized for Antiparasitic, Antimicrobial, Antibacterial, Antiviral, Antitumoral, Antimalarial and Anticonvulsive activities. The aim of the current study is to synthesized novel substituted hydrazones of ketones and aromatic aldehydes and to study their antiparasitic activities against Trypanosoma brucei brucei parasite. Synthesized hydrazone derivatives have been confirmed by elemental analys

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14

Dinda, Soumitra, Tamanna Sultana, Suhana Sultana, et al. "Ruthenocycles of benzothiazolyl and pyridyl hydrazones with ancillary PAHs: synthesis, structure, electrochemistry and antimicrobial activity." New Journal of Chemistry 44, no. 26 (2020): 11022–34. http://dx.doi.org/10.1039/d0nj01447h.

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The antimicrobial activity of ruthenocycles of pyridyl and benzothiazolyl hydrazones has been investigated. The study established that such activity is comparatively higher for the complex containing benzothiazolyl hydrazone.

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15

Zhu, Xu, and Shunsuke Chiba. "TEMPO-mediated allylic C–H amination with hydrazones." Org. Biomol. Chem. 12, no. 26 (2014): 4567–70. http://dx.doi.org/10.1039/c4ob00839a.

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TEMPO-mediated reactions of alkenyl hydrazones afforded azaheterocycles via sp<sup>3</sup> C–H allylic amination. The transformation is featured by a sequence of remote allylic H-radical shift and allylic homolytic substitution with hydrazone radicals.

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16

Vojinovic-Jesic, Ljiljana, Sladjana Novakovic, Vukadin Leovac, and Valerija Cesljevic. "Transition metal complexes with Girard reagents and their hydrazones." Journal of the Serbian Chemical Society 77, no. 9 (2012): 1129–55. http://dx.doi.org/10.2298/jsc120704083v.

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This is the first review dealing with the coordination chemistry of metal complexes with Girard's reagents and their hydrazones. The short introduction points out to chemical properties and significance of these organic compounds. The next section briefly describes synthetic methods for preparing complexes with Girard's reagents, as well as modes of coordination of these ligands. The last two extensive sections review the preparation, stereochemistry and structural characteristics of metal complexes with Girard's hydrazones, including some newer non-hydrazonic derivatives of Girard's reagents,

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17

Kandil, Farouk, Mohamad Khaled Chebani, and Wail Al Zoubi. "Synthesis of Macrocyclic Bis-Hydrazone and Their Use in Metal Cations Extraction." ISRN Organic Chemistry 2012 (February 8, 2012): 1–8. http://dx.doi.org/10.5402/2012/208284.

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Two new macrocyclic hydrazone Schiff bases were synthesized by reaction of succindihydrazide and adipdihydrazide with acetylacetone. Hydrazones have been characterized by elemental analyses and IR, mass, 1H NMR, and 13C NMR spectral data. Hydrazones have been studied by liquid-liquid extraction towards the s-metal ions (Li+, Na+, and K+) and d-metal ions (Cu2+ and Cr3+) from aqueous phase to organic phase. The effect of chloroform and dichloromethane as organic solvents over the metal chlorides extraction was investigated at 25 ± 0.1°C by using flame atomic absorption. We found differences bet

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18

Popiołek, Łukasz. "Updated Information on Antimicrobial Activity of Hydrazide–Hydrazones." International Journal of Molecular Sciences 22, no. 17 (2021): 9389. http://dx.doi.org/10.3390/ijms22179389.

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Hydrazide–hydrazones possess a wide spectrum of bioactivity, including antibacterial, antitubercular, antifungal, anticancer, anti-inflammatory, anticonvulsant, antidepressant, antiviral, and antiprotozoal properties. This review is focused on the latest scientific reports regarding antibacterial, antimycobacterial, and antifungal activities of hydrazide–hydrazones published between 2017 and 2021. The molecules and their chemical structures presented in this article are the most active derivatives, with discussed activities having a hydrazide–hydrazone moiety as the main scaffold or as a side

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19

Al Nasr, Ibrahim S., Waleed S. Koko, Tariq A. Khan, Rainer Schobert, and Bernhard Biersack. "Old Dogs with New Tricks: Antiparasitic Potential of Structurally Diverse 5-Nitrofuran and 5-Nitrothiophene Imines and Acyl Hydrazones." Scientia Pharmaceutica 91, no. 3 (2023): 44. http://dx.doi.org/10.3390/scipharm91030044.

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Miscellaneous imines and acyl hydrazones were prepared from 5-nitrofuraldehyde and 5-nitrothiophene-2-carboxaldehyde. Their activities against Toxoplasma gondii and Leishmania major parasites were evaluated. Promising antiparasitic effects and selectivities were observed for certain acyl hydrazones and imines. Cobalt(II) and copper(II) complexes conserved the high anti-Toxoplasma activities of 3-hydroxy-2-naphthoic carboxyl hydrazone (2a). In addition, sound activities against L. major promastigotes were observed for various analogs of 2a (2b and 2i) and pyrid-2-ylpyrazole-based imines (3g and

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20

Pangal, Anees, Javed A. Shaikh, Mansura Mulani, and Khursheed Ahmed. "SYNTHESIS, ANTICANCER ACTIVITIES AND IN SILICO SCREENING OF 3-ACETYLCOUMARINHYDRAZONE SCAFFOLDS." Journal of Advanced Scientific Research 12, no. 04 Suppl 1 (2021): 225–33. http://dx.doi.org/10.55218/jasr.s1202112425.

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3-acetylcoumarin hydrazone scaffolds, synthesized from 3-acetylcoumarin and substituted benzoic acid hydrazides are reported with structural characterization using IR, HRMS, 1H and 13C-NMR. The In vitro anticancer activities against three human cancer cell lines viz. MCF-7 (human breast cancer cell line), HeLa (human cervical cancer cell line) and SCC-40 (human oral squamous cell carcinoma) are carried out while the tumour selectivity of compounds are tested on the normal human peripheral blood mononuclear cells (PBMCs). The compounds 3ACOH, 3ACDH and 3ACMH exhibited higher sensitivity towards

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21

Zahirović, Adnan, Irnesa Osmanković, Amar Osmanović, et al. "Interaction of Copper(II) Complexes of Bidentate Benzaldehyde Nicotinic Acid Hydrazones with BSA: Spectrofluorimetric and Molecular Docking Approach." Acta Chimica Slovenica 70, no. 1 (2023): 74–85. http://dx.doi.org/10.17344/acsi.2022.7826.

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Two copper(II) complexes of 4-chloro- and 4-dimethylaminobenzaldehyde nicotinic acid hydrazones were prepared and characterized by elemental analysis, mass spectrometry, infrared and electron spectroscopy and conductometry. These rare examples of bis(hydrazonato)copper(II) complexes are neutral complex species with copper(II) center coordinated with two monoanionic bidentate O,N-donor hydrazone ligands coordinated in enol-imine form. The interaction of hydrazone ligands and corresponding copper(II) complexes with CT DNA and BSA was investigated. Copper(II) complexes are slightly effective in b

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22

Sun, Zi-Qiang, Shun-Feng Yu, Xin-Lan Xu, Xiao-Yang Qiu, and Shu-Juan Liu. "Two Vanadium(V) Complexes Derived from Bromo and Chloro-Substituted Hydrazone Ligands: Syntheses, Crystal Structures and Antimicrobial Property." Acta Chimica Slovenica 67, no. 4 (2020): 1281–89. http://dx.doi.org/10.17344/acsi.2020.6236.

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Two vanadium(V) complexes derived from the bromo and chloro-substituted hydrazones N’-(4-bromo-2-hydroxybenzylidene)- 2-chlorobenzohydrazide (H2L1) and N’-(3-bromo-5-chloro-2-hydroxybenzylidene)-3-methylbenzohydrazide (H2L2) with the formula [VOL1(OCH3)(CH3OH)] (1) and [VOL2(OCH3)(CH3OH)] (2) were newly synthesized and characterized by IR, UV-Vis and 1H NMR spectroscopy. The structures of H2L1 and the complexes were further confirmed by single crystal X-ray diffraction. Both vanadium complexes are mononuclear, with the metal atoms coordinated by the hydrazone ligands, methanol ligands, and met

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23

El-Azab, Adel S., Alaa A. M. Abdel-Aziz, Ahmed H. Bakheit, et al. "Remarkable utilization of quinazoline-based homosulfonamide for in vitro cytotoxic effects with triple kinase inhibition activities: cell cycle analysis and molecular docking profile." RSC Advances 15, no. 1 (2025): 541–58. https://doi.org/10.1039/d4ra07174c.

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Hydrazone 5 had a higher mean GI50 (1.1 μM) than gefitinib and erlotinib (2.1 and 7.7 μM). Compared to gefitinib and dinaciclib, hydrazones 5 and 6 strongly inhibit EGFR, HER2, and CDK9 kinases. They are also less toxic to WI-38 than doxorubicin.

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24

Li, Chao-Jun, Jianlin Huang, Xi-Jie Dai, et al. "An Old Dog with New Tricks: Enjoin Wolff–Kishner Reduction for Alcohol Deoxygenation and C–C Bond Formations." Synlett 30, no. 13 (2019): 1508–24. http://dx.doi.org/10.1055/s-0037-1611853.

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The Wolff–Kishner reduction, discovered in the early 1910s, is a fundamental and effective tool to convert carbonyls into methylenes via deoxygenation under strongly basic conditions. For over a century, numerous valuable chemical products have been synthesized by this classical method. The reaction proceeds via the reversible formation of hydrazone followed by deprotonation with the strong base to give an N-anionic intermediate, which affords the deoxygenation product upon denitrogenation and protonation. By examining the mechanistic pathway of this century old classical carbonyl deoxygenatio

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25

Harjeet, Kaur, Manpreet, and Shilpa. "Review on hydrazone and it's biological activities." International Journal of Multidisciplinary Research Transactions 6, no. 4 (2024): 166–81. https://doi.org/10.5281/zenodo.11075191.

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The main traits and attributes of hydrazone are enumerated in its abstract. The chemical compound hydrazone is composed of a particular functional group known as the hydrazone group (-NHN=). Numerous biological activities, such as antibacterial, antiviral, antioxidant, and anticancer properties, are well-known for it. Because of these properties, hydrazone molecules are attractive options for a range of medical and pharmaceutical applications. However, hydrazones' particular biological activity can differ based on their chemical makeup and alterations. To completely comprehend their methods of

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26

Costa, Maximilian, Frances Adhamidhi, Maxim Mastyugin, et al. "Solvent- and Catalyst-Free Environmentally Benign High Hydrostatic Pressure-Assisted Synthesis of Bioactive Hydrazones and the Evaluation of Their Stability Under Various Storage Conditions." Molecules 29, no. 22 (2024): 5287. http://dx.doi.org/10.3390/molecules29225287.

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Our group has seen great promise in using substituted diaryl-hydrazones to alleviate oxidative stress in preeclampsia. Specifically, fluorinated diaryl-hydrazones have shown great efficacy, confirmed via antioxidant assays and animal trials using pregnant mice. In addition to efficient antioxidant properties, these diaryl-hydrazones are also considered non-toxic. While the synthesis of these compounds is relatively simple, it commonly utilizes undesirable solvents and glacial acetic acid as the catalyst; additional solvents are needed for the isolation of the desired products, which negatively

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27

Kaur, Aneet Kamal, Renu Bala, Poonam Kumari, Sumit Sood, and Karan Singh. "Microwave Assisted Vilsmeier-Haack Reaction on Substituted Cyclohexanone Hydrazones: Synthesis of Novel 4,5,6,7-Tetrahydroindazole Derivatives." Letters in Organic Chemistry 16, no. 3 (2019): 170–75. http://dx.doi.org/10.2174/1570178615666180917101637.

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Vilsmeier-Haack reaction is one of the most important chemical reactions used for formylation of electron-rich arens. Even though Vilsmeier-Haack reaction was studied on a wide variety of hydrazones of enolizable ketones, literature lacks the examples of the use of 4-substituted cyclohexanones as a substrate. The cyclization potential of hydrazones of cyclic keto compounds is still interested topic of investigation. In the present study, the reaction of various hydrazines with 4-substituted cyclohexanones was proceeded and the resulted hydrazones in crude form were treated with Vilsmeier- Haac

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28

KASIMBI, D., K. HUSSAIN REDDY, and N. DEVANNA. "Synthesis, Spectral Characterization and Antibacterial Activity of Copper(II) Complexes of Functionalized Hydrazones." Asian Journal of Chemistry 31, no. 6 (2019): 1289–93. http://dx.doi.org/10.14233/ajchem.2019.21942.

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Copper(II) complexes having the formula CuL2 {where, L = 2-acetylthiophene acetoylhydrazone (ATAH), 2-acetylthiophene benzoylhydrazone (ATBH)} have been investigated on the basis of elemental analysis, molar conductivity measurements, magnetic susceptibility, UV-visible, IR and ESR spectral data. Non-electrolytic nature of the complexes are revealed by molar conductance data. IR spectral data suggested that hydrazones act as tridentate ligands. The spin Hamiltonian, orbital reduction and bonding parameters of complexes are calculated using ESR spectra of complexes. The compounds are screened f

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29

Enders, Dieter, and Christoph Thiebes. "Efficient stereoselective syntheses of piperidine, pyrrolidine, and indolizidine alkaloids." Pure and Applied Chemistry 73, no. 3 (2001): 573–78. http://dx.doi.org/10.1351/pac200173030573.

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Recent advances in the diastereo- and enantioselective synthesis of piperidine, pyrrolidine, and indolizidine alkaloids, based on the highly stereoselective 1,2-addition to the CN double bond of chiral aldehyde-SAMP/RAMP hydrazones, are described. The enantioselective syntheses of the pyrrolidine alkaloids bgugaine and (2S,12¢R)-2-(12¢-aminotridecyl)-pyrrolidine, a defense alkaloid of the Mexican bean beetle are reported. Furthermore, the SAMP/RAMP-hydrazone method was applied to the syntheses of two 5,8-disubstituted indolizidine alkaloids that have been extracted from neotropical poison-dart

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Nocheva, Hristina, Stanislava Vladimirova, Diana Tzankova, Lily Peikova, and Maya Georgieva. "Analgesic properties of newly synthesized N pyrrolyl hydrazide hydrazones." Tropical Journal of Pharmaceutical Research 22, no. 1 (2023): 121–27. http://dx.doi.org/10.4314/tjpr.v22i1.17.

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Purpose: To screen a series of newly synthesized N-pyrrolyl hydrazide hydrazones for analgesic activity via Paw-pressure (PP) test and hot plate test (HPT). Methods: The compounds newly synthesized through the classical Paal-Knor cyclization, N-pyrrolyl hydrazide-hydrazones were administered intraperitoneally at a dose of 20 mg/kg. Paw pressure and hot plate tests were applied to assess the analgesic properties. In addition, stress-induced analgesia with naloxone as a non-selective opioid receptor antagonist was performed. Results: The compound (DI-5g), containing an izatine carbon

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31

Çıkla-Süzgün, Pelin, and Ş. Güniz Küçükgüzel. "Recent Advances in Apoptosis: THE Role of Hydrazones." Mini-Reviews in Medicinal Chemistry 19, no. 17 (2019): 1427–42. http://dx.doi.org/10.2174/1389557519666190410125910.

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: The process of programmed cell death in higher eukaryotes (apoptosis), is generally characterized by distinct morphological characteristics and energy-dependent biochemical mechanisms. Apoptosis is considered as a vital component of various processes including normal cell turnover, proper development and functioning of the immune system, hormone-dependent atrophy, embryonic development and chemical-induced cell death. Apoptosis seems to play an important key role in the progression of several human diseases like Alzheimer's disease, Parkinson's disease and many types of cancer. Promotion of

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32

Hamed, Atef A., Hesham F. Bader, and El-Sayed H. El-Ashry. "4′, x-Seco And 4′,x-4′,5′-Diseco C-Nucleosides From 2-Hydrazino-(3H)- Thieno [2,3-D] Pyrimidin-4-Ones." Zeitschrift für Naturforschung B 56, no. 8 (2001): 826–36. http://dx.doi.org/10.1515/znb-2001-0817.

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Cyclization of 2-hydrazino-5,6-dimethyl-3H-thieno[2,3-d]pyrimidin-4-one (1) with acetic acid gave 3,6,7-trimethyl-l,2,4-triazolo[3,4-a]thieno[2,3-d] pyrimidin-5-one (5) whose Dimroth rearrangement gave 2,6,7-trimethyl-l,2,4-triazolo[3,4-a]thieno[2,3-d]pyrimidin-5-one (11). Alternatively, 5 was obtained from the dehydrogenative cyclization of acetaldehyde 5,6- dimethyl-4-3H-oxo-thieno[2,3-d]pyrimidin-2-yl hydrazone (7). Reaction of 1 and 2 with a number of sugars gave the respective hydrazones 19 and 20. Those of the D-glucose exist in the cyclic pyranosyl structure in addition to minor amounts

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Chandrasekhar, Vadapalli, Venkatasubbaiah Krishnan, Arunachalampillai Athimoolam, and Gurusamy Thangavelu Senthil Andavan. "New hybrid inorganic-organic polymers containing cyclophosphazenes as pendant groups: Cyclophosphazene ligands containing hydrazone linkages and their conversion to polymers." Canadian Journal of Chemistry 80, no. 11 (2002): 1415–20. http://dx.doi.org/10.1139/v02-099.

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The reaction of the cyclotriphosphazene N3P3Cl5[O-C6H4-p-C6H4-p-CH=CH2] (2) with 10 equiv of N-methylhydrazine proceeds in a regio-specific manner to afford the multi-functional hydrazide N3P3[N(Me)NH2]5[O- C6H4-p-C6H4-p-CH=CH2] (3). Condensation of 3 with o-hydroxy benzaldehyde or pyridine-2-carboxaldehyde affords the corresponding hydrazones N3P3[N(Me)N=CH-C6H4-o-OH]5[O-C6H4-p-C6H4-p-CH=CH2] (4) and N3P3[N(Me)N=CH-C6H4N]5[O-C6H4-p-C6H4-p-CH=CH2] (5), respectively. These hydrazones can be homopolymerized to afford polymers 6 and 7 containing multi-site coordinating cyclophosphazenes as pendan

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34

Sarkar, Souvik, Asim A. Siddiqui, Shubhra J. Saha, et al. "Antimalarial Activity of Small-Molecule Benzothiazole Hydrazones." Antimicrobial Agents and Chemotherapy 60, no. 7 (2016): 4217–28. http://dx.doi.org/10.1128/aac.01575-15.

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ABSTRACTWe synthesized a new series of conjugated hydrazones that were found to be active against malaria parasitein vitro, as well asin vivoin a murine model. These hydrazones concentration-dependently chelated free iron and offered antimalarial activity. Upon screening of the synthesized hydrazones, compound 5f was found to be the most active iron chelator, as well as antiplasmodial. Compound 5f also interacted with free heme (KD[equilibrium dissociation constant] = 1.17 ± 0.8 μM), an iron-containing tetrapyrrole released after hemoglobin digestion by the parasite, and inhibited heme polymer

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35

Silva, Laís Peres, Ivanilson Pimenta Santos, Dahara Keyse Carvalho Silva, et al. "Molecular Hybridization Strategy on the Design, Synthesis, and Structural Characterization of Ferrocene-N-acyl Hydrazones as Immunomodulatory Agents." Molecules 27, no. 23 (2022): 8343. http://dx.doi.org/10.3390/molecules27238343.

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Immunomodulatory agents are widely used for the treatment of immune-mediated diseases, but the range of side effects of the available drugs makes necessary the search for new immunomodulatory drugs. Here, we investigated the immunomodulatory activity of new ferrocenyl-N-acyl hydrazones derivatives (SintMed(141–156). The evaluated N-acyl hydrazones did not show cytotoxicity at the tested concentrations, presenting CC50 values greater than 50 µM. In addition, all ferrocenyl-N-acyl hydrazones modulated nitrite production in immortalized macrophages, showing inhibition values between 14.4% and 74.

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Krátký, Martin, Katarína Svrčková, Quynh Anh Vu, Šárka Štěpánková, and Jarmila Vinšová. "Hydrazones of 4-(Trifluoromethyl)benzohydrazide as New Inhibitors of Acetyl- and Butyrylcholinesterase." Molecules 26, no. 4 (2021): 989. http://dx.doi.org/10.3390/molecules26040989.

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Based on the broad spectrum of biological activity of hydrazide–hydrazones, trifluoromethyl compounds, and clinical usage of cholinesterase inhibitors, we investigated hydrazones obtained from 4-(trifluoromethyl)benzohydrazide and various benzaldehydes or aliphatic ketones as potential inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). They were evaluated using Ellman’s spectrophotometric method. The hydrazide–hydrazones produced a dual inhibition of both cholinesterase enzymes with IC50 values of 46.8–137.7 µM and 19.1–881.1 µM for AChE and BuChE, respectively. The m

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Pogonin, Aleksandr E., George A. Gamov, Maksim N. Zavalishin, and Valentin A. Sharnin. "CONFORMATIONAL BEHAVIOR OF HYDRAZONE DERIVED FROM PYRIDOXAL 5’-PHOSPHATE AND ISONIAZID." IZVESTIYA VYSSHIKH UCHEBNYKH ZAVEDENIY KHIMIYA KHIMICHESKAYA TEKHNOLOGIYA 61, no. 12 (2018): 101–7. http://dx.doi.org/10.6060/ivkkt.20186112.5846.

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The hydrazones derived from pyridoxal or pyridoxal 5’-phosphate and heterocyclic hydrazides are of interest due to their potential biological activity and metal sensing properties. These characteristics of hydrazones could be dependent on the conformation equilibria of molecule since the most stable conformer could differ from the one with the highest affinity towards biomolecule or metal ion. In the present contribution, deprotonated hydrazone formed by pyridoxal 5’-phosphate and isoniazid (PLP-INH3-) was studied by means of quantum chemistry. Three rotations leading to eight conformers are p

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38

Dammene Debbih, Ouafa, Assia Sid, Rafika Bouchene, Sofiane Bouacida, Wissam Mazouz, and Noureddine Gherraf. "Two hydrazones derived from 1-aryl-3-(p-substituted phenyl)prop-2-en-1-one: synthesis, crystal structure, Hirshfeld surface analysis andin vitrobiological properties." Acta Crystallographica Section C Structural Chemistry 74, no. 6 (2018): 703–14. http://dx.doi.org/10.1107/s2053229618006812.

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Two chalcones were synthesized by the aldolic condensation of enolizable aromatic ketones with substituted benzaldehydes under Claisen–Schmidt reaction conditions and then treated with 2,4-dinitrophenylhydrazine to yield their corresponding hydrazones. The two (E,Z)-2,4-dinitrophenylhydrazone structures, namely (Z)-1-(2,4-dinitrophenyl)-2-[(E)-3-(4-methylphenyl)-1-phenylallylidene]hydrazine, C22H18N4O4, (H1), and (Z)-1-[(E)-3-(4-chlorophenyl)-1-(naphthalen-1-yl)allylidene]-2-(2,4-dinitrophenyl)hydrazine, C25H17ClN4O4, (H2), were isolated by recrystallization and characterized by FT–IR, UV–Vis,

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39

Kapusterynska, Anna, Christian Bijani, Damian Paliwoda, et al. "Mechanochemical Studies on Coupling of Hydrazines and Hydrazine Amides with Phenolic and Furanyl Aldehydes—Hydrazones with Antileishmanial and Antibacterial Activities." Molecules 28, no. 13 (2023): 5284. http://dx.doi.org/10.3390/molecules28135284.

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Hydrazone compounds represent an important area of research that includes, among others, synthetic approaches and biological studies. A series of 17 hydrazones have been synthesized by mechanochemical means. The fragments chosen were phenolic and furanyl aldehydes coupled with 12 heterocyclic hydrazines or hydrazinamides. All compounds can be obtained quantitatively when operating on a planetary ball mill and a maximum reaction time of 180 min (6 cycles of 30 min each). Complete spectroscopic analyses of hydrazones revealed eight compounds (3–5, 8–11, 16) present in one geometric form, six com

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Shah, Muhammad Abdullah, Ala Uddin, Muhammad Raza Shah, et al. "Synthesis and Characterization of Novel Hydrazone Derivatives of Isonicotinic Hydrazide and Their Evaluation for Antibacterial and Cytotoxic Potential." Molecules 27, no. 19 (2022): 6770. http://dx.doi.org/10.3390/molecules27196770.

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Hydrazones are active compounds having an azomethine –NHN=CH group and are widely studied owing to their ease of preparation and diverse pharmacological benefits. Novel isonicotinic hydrazone derivatives of vanillin aldehyde and salicyl aldehyde were synthesized that had azomethine linkages and were characterized by UV–Visible, FTIR, EI-MS, 1H-NMR and 13C-NMR spectroscopy. The compounds were screened for their antibacterial activity against Staphylococcus aureus, Bacillus subtilus, and Escherichia coli using disc diffusion and minimum inhibitory concentration (MIC) methods. For cytotoxicity, a

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Siemann, Stefan, Darryl P. Evanoff, Laura Marrone, Anthony J. Clarke, Thammaiah Viswanatha та Gary I. Dmitrienko. "N-Arylsulfonyl Hydrazones as Inhibitors of IMP-1 Metallo-β-Lactamase". Antimicrobial Agents and Chemotherapy 46, № 8 (2002): 2450–57. http://dx.doi.org/10.1128/aac.46.8.2450-2457.2002.

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ABSTRACT Members of a family of N-arylsulfonyl hydrazones have been identified as novel inhibitors of IMP-1, a metallo-β-lactamase of increasing prevalence. Structure-activity relationship studies have indicated a requirement for bulky aromatic substituents on each side of the sulfonyl hydrazone backbone for these compounds to serve as efficient inhibitors of IMP-1. Molecular modeling has provided insight into the structural basis for the anti-metallo-β-lactamase activity exhibited by this class of compounds.

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ANENKO, D. S., P. S. BOBROV, I. L. ABISALOVA, G. A. SUBOCH, E. O. SERGEEVA, and T. N. GLIZHOVA. "ANTIOXIDANT ACTIVITY OF QUINOXALYL HYDRAZONES OF 2-HYDROXYIMINO-1,3-DICARBONYL COMPOUNDS." Chemistry for Sustainable Development 31, no. 4 (2023): 349–53. http://dx.doi.org/10.15372/csd2023477.

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Biosimilarity and pharmacokinetic descriptors were obtained using SwissADME and ADMETlab 2.0 web services. Analysis of the obtained descriptors shows that, according to Lipinski’s rule, quinoxalyl hydrazones of 2-hydroximino-1,3-dioxocompounds may be promising candidates for drug development for oral administration. Analysis of the pharmacokinetic descriptors of the structures studied shows that, according to the in silico predictions, the compounds can penetrate the blood-brain barrier, be absorbed in the gastrointestinal tract, bind to plasma proteins, be rapidly eliminated from target cells

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Suvarapu, Lakshmi Narayana, Young Kyo Seo, Sung-Ok Baek, and Varada Reddy Ammireddy. "Review on Analytical and Biological Applications of Hydrazones and their Metal Complexes." E-Journal of Chemistry 9, no. 3 (2012): 1288–304. http://dx.doi.org/10.1155/2012/534617.

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Hydrazones are very important group of analytical regents for the determination of various metal ions by using various analytical techniques. Besides this use of hydrazones are also having biological activities also. In this paper we first discussed about the chemical nature of hydrazones and their biological activities. We mainly focused on the papers which were published during 1980-2011 on analytical applications (spectrophotometric and spectrofluorimetric) of hydrazones. We gave the total established conditions for the determination of various metal ions with hydrazones.

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Kasimbi, D., K. Hussain Reddy, and N. Devanna. "Synthesis, Spectral Characterization and Antibacterial Activity of Functionalized Hydrazones." Oriental Journal of Chemistry 35, no. 2 (2019): 557–62. http://dx.doi.org/10.13005/ojc/350208.

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New hydrazones have been synthesized by condensing 2-acetylthiophene with acetic hydrazide and benzhydrazide. The synthesized hydrazones viz. 2-acetylthiophene acetoylhydrazone (ATAH), 2-acetylthiophene benzoylhydrazone (ATBH) are characterized in the light of physicochemical and analytical data. Structures of ATAH and ATBH are confirmed by FT-IR, 1H-NMR and Mass spectral data. The hydrazones are screened for their anti-bacterial activities against E Coli, Bacillus cereus, Staphylococcus aureus and Pseudomonas aureoginos. Acetoyl hydrazones are found to show more antibacterial activity than th

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45

Ekram Abdullah Basheer, Kalid Matny Al-jaanaby, and Feras Shauki Al-joboury. "Synthesis a Number of Heterocyclic Compounds Derived From Levofloxacin." Tikrit Journal of Pure Science 20, no. 5 (2023): 84–95. http://dx.doi.org/10.25130/tjps.v20i5.1244.

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In this paper, the preparation a number of heterocyclic compounds five membered rings like oxadiazole, imidazolidine, thiozolidine, tetrazole, azetidine 2-on. Hydrazide (1) was synthesized from the reaction of levofloxacin with hydrazine hydrate. Hydrazone compounds (2-9) were synthesized from the reaction (1) with a number of aldehydes, and 3-acetyl-1,3,4-oxadiazol (10-17) was prepared from the reaction of hydrazones (2-9) with acetic anhydride, 5-oxo-2-aryl imadazoldine derivative (18-25) were prepared from the reaction of hydrazone derivatives (2-9) with glycine, while the reaction of hydra

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Kyne, Sara H., and Carl H. Schiesser. "Ab Initio Studies of Carbonyl Radical Additions to Hydrazone Systems." Australian Journal of Chemistry 62, no. 7 (2009): 728. http://dx.doi.org/10.1071/ch09165.

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Ab initio and DFT calculations reveal that intermolecular radical additions of both acyl and oxyacyl radials to hydrazones occur through SOMO → π*hydrazone, πhydrazone → SOMO and LPN → SOMO interactions between the radical and the hydrazone π-system. Both acetyl and methoxycarbonyl radicals show preference for addition to the carbon end of the carbon–nitrogen π-bond. At the highest level of theory used in this study (G2//MP2(full)/6-31G*), energy barriers of 11.2 and 22.6 kJ mol–1 are calculated for acetyl radical addition to the carbon and nitrogen-ends of N-aminomethanimine respectively. The

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Brown, D. Sean, Jason V. Jollimore, Marcus P. Merrin, Keith Vaughan, and Donald L. Hooper. "Formation of methyl 2-arylhydrazono-3-oxobutanoates and 2-arylhydrazono-3-oxobutanenitriles during the coupling reaction of arenediazonium ions with methyl 3-aminocrotonate and 3-aminocrotononitrile." Canadian Journal of Chemistry 73, no. 2 (1995): 169–75. http://dx.doi.org/10.1139/v95-025.

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Reaction of aryldiazonium salts with methyl 3-aminocrotonate (1) affords high yields of the methyl 2-arylhydrazono-3-oxobutanoates (4); analogous diazonium coupling with 3-aminocrotononitrile (2) gives the 2-arylhydrazono-3-oxobutanenitriles (5). The hydrazones are the product of diazonium coupling at the C2-vinylic carbon, concomitant with hydrolysis of the 3-amino substituent to the 3-oxo derivative; there is no evidence for the formation of a triazene (6), which would be the product of N-coupling. All hydrazones (4a–e and 5a–d) have been fully characterized by IR and 1H and 13C NMR spectros

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Sun, Hong-Xia, Shao-Xuan Gong, Hong-Yang Zhang, et al. "Research Progress on the Reaction of Carbon Dioxide with Hydrazones and Their Derivatives." Molecules 30, no. 9 (2025): 1987. https://doi.org/10.3390/molecules30091987.

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CO2, an abundant and renewable C1 source, presents significant potential for applications in organic synthesis. Hydrazones, recognized for their distinctive properties, exhibit high versatility in synthetic chemistry, facilitating numerous chemical transformations. Given their crucial roles in organic synthesis, the combination of CO2 with hydrazones has garnered increasing research interest. This review provides a comprehensive summary of recent progress in reactions involving CO2 and hydrazones or their derivatives. These include the coupling of amines and N-tosylhydrazones with CO2, the ump

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Tisovský, Pavol, Miroslav Horváth, Klaudia Csicsai, et al. "Isatin-1,8-Naphthalimide Hydrazones: A Study of Their Sensor and ON/OFF Functionality." Molecules 24, no. 3 (2019): 397. http://dx.doi.org/10.3390/molecules24030397.

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Five novel hydrazones derived from substituted isatins were synthesized as potential anion sensors. Using UV-VIS, FTIR, NMR and fluorescence spectroscopy, these compounds’ tautomeric equilibrium and Z-E photoisomerization were studied in DMF and CHCl3, depending on the hydrazone concentrations, the presence of basic anions and light stimulation. Anion recognition aspects (PF6−, HSO4−, Br−, Cl−, NO3−, F− and CH3COO−) and these receptors’ detection limits were also studied. We also tested the light-stimulated ON-OFF functionality of these compounds in the presence or absence of these anions.

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Teneva, Yoanna, Rumyana Simeonova, Orlin Besarboliev, Hristina Sbirkova-Dimitrova, and Violina T. Angelova. "X-ray Single-Crystal Analysis, Pharmaco-Toxicological Profile and Enoyl-ACP Reductase-Inhibiting Activity of Leading Sulfonyl Hydrazone Derivatives." Crystals 14, no. 6 (2024): 560. http://dx.doi.org/10.3390/cryst14060560.

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Taking into consideration the growing resistance towards currently available antimycobacterials, there is still an unmet need for the development of new chemotherapeutic agents to combat the infectious agents. This study presents X-ray single-crystal analysis to verify the structure of leading sulfonyl hydrazone 3b, which has proven its potent antimycobacterial activity against Mycobacterium tuberculosis H37Rv with an MIC value of 0.0716 μM, respectively, low cytotoxicity, and very high selectivity indexes (SI = 2216), and which has been fully characterized by Nuclear Magnetic Resonance (NMR)

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