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Dissertations / Theses on the topic 'Hydrocephalus. Microdialysis. Cerebrospinal Fluid'

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Published: 4 June 2021

Last updated: 1 February 2022

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1

Ågren, Wilsson Aina. "On the pathophysiology of idiopathic adult hydrosephalus syndrome : energy metabolism, protein patterns, and intracranial pressure." Umeå : Univ, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-520.

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2

Ågren, Wilsson Aina. "On the pathophysiology of idiopathic adult hydrosephalus syndrome : energy metabolism, protein patterns, and intracranial pressure." Doctoral thesis, Umeå universitet, Neurologi, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-520.

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The symptoms in Idiopathic Adult Hydrocephalus Syndrome (IAHS) – gait disturbance, incontinence, and cognitive deficit – correlate anatomically to neuronal dysfunction in periventricular white matter. The pathophysiology is considered to include a cerebrospinal fluid (CSF) hydrodynamic disturbance, including pressure oscillations (“B waves”), in combination with cerebrovascular disease. IAHS and Subcortical Arteriosclerotic Encephalopathy (SAE) show clinical similarities, which constitutes a diagnostic problem. The aim of this thesis was to investigate biochemical markers in CSF, possibly rela

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3

Samuel, Madan. "Quantitative assessment of the tympanic membrane displacement test in children and adolescents with shunted hydrocephalus : reproducibility of tympanic membrane displacement test measurements in children with shunted hydrocephalus." Thesis, University of Southampton, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.266378.

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4

Cains, Sarah. "Cerebrospinal fluid folate and the development of the cerebral cortex in congenital hydrocephalus." Thesis, University of Manchester, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.518429.

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5

Lebret, Alain. "Study on the cerebrospinal fluid volumes." Thesis, Paris Est, 2013. http://www.theses.fr/2013PEST1088/document.

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Cette thèse contribue au manque d'outils informatiques pour l'analyse d'images médicales et le diagnostic, en particulier en ce qui concerne l'étude des volumes du liquide cérébrospinal. La première partie concerne la mesure du volume des compartiments du liquide à partir d'images corps entier, pour une population composée d'adultes sains et de patients atteints d'hydrocéphalie. Les images sont obtenues à partir d'une séquence IRM développée récemment et mettant en évidence le liquide par rapport aux structures voisines, de manière à faciliter sa segmentation. Nous proposons une méthode automa

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6

Whitehouse, Helen Eleri. "Methods to assess CSF dynamics and the mechanical properties of the cerebral mantel in hydrocephalus." Thesis, University of London, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.322325.

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7

Andersson, Nina. "Cerebrospinal fluid infusion methods : development and validation on patients with idiopathic normal pressure hydrocephalus." Doctoral thesis, Umeå : Univ, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1359.

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8

Lebret, Alain, and Alain Lebret. "Study on the cerebrospinal fluid volumes." Phd thesis, Université Paris-Est, 2013. http://tel.archives-ouvertes.fr/tel-00939308.

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This work aims to contribute to the lack of computational methods for medical image analysis and diagnosis about the study of cerebrospinal fluid volumes. In the first part, we focus on the volume assessment of the fluid spaces, from whole body images, in a population consisting of healthy adults and hydrocephalus patients. To help segmentation, these images, obtained from a recent "tissue-specific" magnetic resonance imaging sequence, highlight cerebrospinal fluid unlike its neigh borhood structures. We propose automatic segmentation and separation methods of the different spaces, which allow

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9

Jingami, Naoto. "Two-Point Dynamic Observation of Alzheimer’s Disease Cerebrospinal Fluid Biomarkers in Idiopathic Normal Pressure Hydrocephalus." Kyoto University, 2020. http://hdl.handle.net/2433/253481.

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10

Virhammar, Johan. "Idiopathic Normal Pressure Hydrocephalus : Cerebrospinal Fluid Tap Test and Magnetic Resonance Imaging as Preoperative Prognostic Investigations." Doctoral thesis, Uppsala universitet, Neurologi, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-222779.

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Idiopathic normal pressure hydrocephalus (iNPH) is a condition with dilated cerebral ventricles but intracranial pressure within normal limits. The symptoms of gait impairment, cognitive decline and urinary incontinence develop gradually. Treatment with shunt insertion results in improvement in eight out of ten patients. The cerebrospinal fluid tap test (CSF TT) and preoperative magnetic resonance imaging (MRI) are methods used to select patients who may benefit from shunt surgery, but they are performed and interpreted differently in different centers throughout the world. The aim of this the

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11

Mwenda, Lona Albertha. "An Examination of Lumbar and Ventricular Cerebrospinal Fluid Findings in Children with Tuberculous Meningitis and Hydrocephalus." Master's thesis, Faculty of Health Sciences, 2019. http://hdl.handle.net/11427/31073.

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Background: Childhood tuberculous meningitis (TBM) has poor outcomes. These are often associated with delayed diagnosis because early diagnosis and treatment is challenging. Existing diagnostic criteria use CSF characteristics to suspect TBM. However, lumbar and ventricular CSF may differ. These differences have not been well characterised Sometimes only ventricular CSF is available and decisions about surgical treatment may be influenced by CSF characteristics. This study examined CSF parameters from lumbar and ventricular compartments in patients with TBM and hydrocephalus who required neuro

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12

Tully, Brett. "Allostasis of cerebral water : modelling the transport of cerebrospinal fluid." Thesis, University of Oxford, 2010. http://ora.ox.ac.uk/objects/uuid:168586f0-f34a-4d5e-8acf-822cd0e1bfe2.

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A validated model of water transport in the cerebral environment is both an ambitious and timely task; many brain diseases relate to imbalances in water regulation. From tumours to strokes, chronic or acute, transport of fluid in the brain plays a crucial role. The importance and complexity of the brain, together with the range of unmet clinical needs that are connected with this organ,make the current research a high-priority. One of the most paradoxical cerebral conditions, hydrocephalus, serves as an excellent metric for judging the success of anymodel developed. In particular, normal press

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13

Andersson, Kennet. "Assessment of cerebrospinal fluid system dynamics : novel infusion protocol, mathematical modelling and parameter estimation for hydrocephalus investigations." Doctoral thesis, Umeå universitet, Radiofysik, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-42383.

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Patients with idiopathic normal pressure hydrocephalus (INPH) have a disturbance in the cerebrospinal fluid (CSF) system. The treatment is neurosurgical – a shunt is placed in the CSF system. The infusion test is used to assess CSF system dynamics and to aid in the selection of patients that will benefit from shunt surgery. The infusion test can be divided into three parts: a mathematical model, an infusion protocol and a parameter estimation method. A non-linear differential equation is used to mathematically describe the CSF system, where two important parameters are the outflow conductance

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14

Arnell, Kai. "Cerebrospinal Fluid Shunts in Children : Technical Considerations and Treatment of Certain Complications." Doctoral thesis, Uppsala University, Department of Surgical Sciences, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8295.

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<p>Ventriculo-peritoneal shunting is the most commonly used method for the treatment of paediatric hydrocephalus. Despite improved shunts and surgical techniques there are still complications. This retrospective study focuses on diagnoses and treatment of shunt malfunction and infections. Cost/benefit of using an adjustable shunt was assessed. Two adjustable cerebrospinal fluid shunts and their compatible antisiphon devices were compared in-vitro.</p><p>In 21 of 46 children the standard shunt was changed to an adjustable one due to over-drainage. Adjustment of the shunt was performed in 73% of

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15

Wichern, Donald Monte. "A Framework for an Implantable Wireless Pressure and Volume Sensor Focusing on the Diagnosis and Treatment of Shunt Failure in Hydrocephalus Patients." Diss., CLICK HERE for online access, 2006. http://contentdm.lib.byu.edu/ETD/image/etd1162.pdf.

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16

Deshpande, Abhishek. "Vascular Endothelial Growth Factor Receptor-2 (VEGFR-2) and blood vessel density changes in an experimental model of Chronic Hydrocephalus." Kent State University / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=kent1279288736.

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17

Cheng, Shao Koon Graduate School of Biomedical Engineering Faculty of Engineering UNSW. "The role of brain tissue mechanical properties and cerebrospinal fluid flow in the biomechanics of the normal and hydrocephalic brain." Awarded by:University of New South Wales. Graduate School of Biomedical Engineering, 2006. http://handle.unsw.edu.au/1959.4/27292.

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The intracranial system consists of three main basic components - the brain, the blood and the cerebrospinal fluid. The physiological processes of each of these individual components are complex and they are closely related to each other. Understanding them is important to explain the mechanisms behind neurostructural disorders such as hydrocephalus. This research project consists of three interrelated studies, which examine the mechanical properties of the brain at the macroscopic level, the mechanics of the brain during hydrocephalus and the study of fluid hydrodynamics in both the normal an

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18

Saraiva, Carolina Rebocho Vilas. "Hidrocefalia em canídeos : a propósito de dezasseis casos clínicos." Master's thesis, Universidade de Lisboa. Faculdade de Medicina Veterinária, 2016. http://hdl.handle.net/10400.5/11138.

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Dissertação de Mestrado Integrado em Medicina Veterinária<br>A hidrocefalia é a doença congénita do sistema nervoso central mais comum em cães. Traduz--se numa distensão ativa do sistema ventricular cerebral resultante de uma passagem inadequada do líquido cefalorraquidiano, desde o seu local de produção até ao local de absorção. A obstrução pode ocorrer ao longo de todo o percurso e, é normalmente de origem congénita, podendo também ser adquirida. Os objetivos deste estudo consistiram na caracterização de uma amostra de canídeos (n=16) relativamente à raça, idade, sexo, porte corporal, sinto

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19

Behrens, Anders. "Measurements in Idiopathic Normal Pressure Hydrocephalus : Computerized neuropsychological test battery and intracranial pulse waves." Doctoral thesis, Umeå universitet, Klinisk neurovetenskap, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-96195.

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Idiopathic Normal Pressure Hydrocephalus (INPH) is a condition affecting gait, cognition and continence. Radiological examination reveals enlarged ventricles of the brain. A shunt that drains CSF from the ventricles to the abdomen often improves the symptoms. Much research on INPH has been focused on identifying tests that predict the outcome after shunt surgery. As part of this quest, there are attempts to find measurement methods of intracranial parameters that are valid, reliable, tolerable and safe for patients. Today's technologies for intracranial pressure (ICP) measurement are invasive,

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20

Qvarlander, Sara. "Analysis of ICP pulsatility and CSF dynamics : the pulsatility curve and effects of postural changes, with implications for idiopathic normal pressure hydrocephalus." Doctoral thesis, Umeå universitet, Radiofysik, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-82784.

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The volume defined by the rigid cranium is shared by the brain, blood and cerebrospinal fluid (CSF). With every heartbeat the arterial blood volume briefly increases and venous blood and CSF are forced out of the cranium, leading to pulsatility in CSF flow and intracranial pressure (ICP). Altered CSF pulsatility has been linked to idiopathic normal pressure hydrocephalus (INPH), which involves enlarged cerebral ventricles and symptoms of gait/balance disturbance, cognitive decline and urinary incontinence that may be improved by implantation of a shunt. The overall aim of this thesis was to in

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21

Dalla, Corte Amauri. "Fatores associados à hidrocefalia em pacientes com mucopolissacaridose." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2017. http://hdl.handle.net/10183/172116.

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Introdução: As mucopolissacaridoses (MPS) constituem um grupo de doenças lisossômicas caracterizadas pela deficiência de uma das enzimas responsáveis pela degradação dos glicosaminoglicanos (GAGs). É difícil determinar a incidência precisa de hidrocefalia em pacientes com MPS, pois não possui uma definição formal por consenso. Além disso, é difícil distinguir a hidrocefalia comunicante da dilatação ventricular secundária à atrofia cerebral, porque ambas apresentam características clínicas e neuroradiológicas comuns. Embora várias técnicas sejam usadas para identificar pacientes com MPS com mai

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22

Lenfeldt, Niklas. "The search for reversibility of Idiopathic normal pressure hydrocephalus : Aspects on intracranial pressure measurments and CSF volume alteration." Doctoral thesis, Umeå universitet, Farmakologi och klinisk neurovetenskap, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1422.

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BACKGROUND: Idiopathic normal pressure hydrocephalus (INPH) is still a syndrome generating more questions than answers. Today, research focuses mainly on two areas: understanding the pathophysiology – especially how the malfunctioning CSF system affects the brain parenchyma – and finding better methods to select patients benefiting from a shunt operation. This thesis targets the aspect of finding better selection methods by investigating the measurability of intracranial pressure via lumbar space, and determining if intraparenchymal measurement of long-term ICP-oscillations (B-waves) could be

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23

Sosa, Carrero Jordana Mag Lui [Verfasser], and Martin [Akademischer Betreuer] Schuhmann. "Computerized analysis of intracranial pressure and cerebrospinal fluid dynamics in patients with idiopathic normal pressure hydrocephalus and positive clinical response to lumbar CSF drainage / Jordana Mag Lui Sosa Carrero ; Akademischer Betreuer: Martin Schuhmann." Tübingen : Universitätsbibliothek Tübingen, 2017. http://d-nb.info/1199627240/34.

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24

Sosa, Carrero Jordana Mag-Lui [Verfasser], and Martin [Akademischer Betreuer] Schuhmann. "Computerized analysis of intracranial pressure and cerebrospinal fluid dynamics in patients with idiopathic normal pressure hydrocephalus and positive clinical response to lumbar CSF drainage / Jordana Mag Lui Sosa Carrero ; Akademischer Betreuer: Martin Schuhmann." Tübingen : Universitätsbibliothek Tübingen, 2017. http://d-nb.info/1199627240/34.

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25

Spirakis, Susan E. "Incidence of Unilateral, High Frequency, Sensorineural Hearing Loss in Shunt Treated Hydrocephalic Children Ipsilateral to Shunt Placement." Scholar Commons, 2000. https://scholarcommons.usf.edu/etd/1548.

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The purpose of this study was to investigate further the characteristics of hearing loss in ventriculoperitoneal (VP) shunted hydrocephalus. Twelve (VP) shunt treated hydrocephalus children participated in this study. The etiology of the hydrocephalus was either intraventricular hemorrhage or spina bifida. A recent neurological examination reported the shunt to be patent in each child. Audiometric examination included pure tone air conduction thresholds, tympanometry, contralateral and ipsilateral acoustic reflex thresholds and distortion product otoacoustic emissions (DPOAEÊ¹s). A unilateral,

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26

Eisenträger, Almut. "Finite element simulation of a poroelastic model of the CSF system in the human brain during an infusion test." Thesis, University of Oxford, 2012. http://ora.ox.ac.uk/objects/uuid:372f291f-cf36-48ef-8ce8-d4c102bce9e3.

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Cerebrospinal fluid (CSF) fills a system of cavities at the centre of the brain, known as ventricles, and the subarachnoid space surrounding the brain and the spinal cord. In addition, CSF is in free communication with the interstitial fluid of the brain tissue. Disturbances in CSF dynamics can lead to diseases that cause severe brain damage or even death. So-called infusion tests are frequently performed in the diagnosis of such diseases. In this type of test, changes in average CSF pressure are related to changes in CSF volume through infusion of known volumes of additional fluid. Traditiona

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27

Reiss-Zimmermann, Martin, Michael Scheel, Markus Dengl, Matthias Preuß, Dominik Fritzsch, and Karl-Titus Hoffmann. "The influence of lumbar spinal drainage on diffusion parameters in patients with suspected normal pressure hydrocephalus using 3T MRI." Sage, 2014. https://tud.qucosa.de/id/qucosa%3A35424.

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Background: Normal pressure hydrocephalus (NPH) has been an ongoing and challenging field of research for the past decades because two main issues are still not fully understood: the pathophysiologic mechanisms underlying ventricular enlargement and prediction of outcome after surgery. Purpose: To evaluate changes in diffusion tensor imaging (DTI) derived parameters in patients with suspected normal pressure hydrocephalus before and after withdrawal of cerebrospinal fluid (CSF). Material and Methods: Twenty-four consecutive patients with clinical and radiological suspicion of NPH and 14 agemat

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28

Oliveira, Matheus Fernandes de. "Derivação ventriculosinusal retrógrada em lactentes com hidrocefalia após correção de mielomeningocele." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/5/5138/tde-19062017-161737/.

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INTRODUÇÃO. Atualmente, o tratamento da hidrocefalia é realizado principalmente através de uma Derivação ventrículo-peritoneal (DVP). Este estudo tem como objetivo descrever a aplicação da derivação ventrículosinusal retrógrada (DVSR) em pacientes com hidrocefalia após o tratamento cirúrgico de mielomeningocele. MÉTODO. Estudo prospectivo, randomizado e controlado. Foram selecionados consecutivamente 9 pacientes com hidrocefalia após correção cirúrgica de mielomeningocele de janeiro de 2010 a janeiro de 2012. Os pacientes foram submetidos à DVSR ou DVP eletiva. Cinco submetidos à DVSR e 4 à DV

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29

Del, Bigio Marc Ronald. "Experimental hydrocephalus and cerebrospinal fluid shunting in rabbits." 1987. http://hdl.handle.net/1993/15444.

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30

Wilkie, Kathleen Patricia. "Cerebrospinal Fluid Pulsations and Aging Effects in Mathematical Models of Hydrocephalus." Thesis, 2010. http://hdl.handle.net/10012/5363.

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In this Thesis we develop mathematical models to analyze two proposed causative mechanisms for the ventricular expansion observed in hydrocephalus: cerebrospinal fluid pulsations and small transmantle pressure gradients. To begin, we describe a single compartment model and show that such simple one-dimensional models cannot represent the complex dynamics of the brain. Hence, all subsequent models of this Thesis are spatio-temporal. Next, we develop a poroelastic model to analyze the fluid-solid interactions caused by the pulsations. Periodic boundary conditions are applied and the system is

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31

Preston, Daniel. "TRPV4 in the Choroid Plexus Epithelium: Pathway Analysis and Implications for Cerebrospinal Fluid Production." Thesis, 2019. http://hdl.handle.net/1805/21335.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>Hydrocephalus is a disease characterized by an increase in cerebrospinal fluid (CSF) in the ventricles of the brain. This manifests as a result of either overproduction or underabsorption of CSF leading to increases in pressure, swelling and loss of brain matter. Current treatments for this disease include surgical interventions via the introduction of shunts or endoscopic third ventriculostomy, both of which aim to redirect flow of CSF in to another cavity for absorption. Limited pharmacotherapies are available in the treatment of h

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32

Chou, Mei-Chuan, and 周美鵑. "Analysis of changes of gait and cognition after cerebrospinal fluid (CSF) tap test in patients with normal pressure hydrocephalus." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/96771705295264723780.

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碩士<br>高雄醫學大學<br>醫學系神經學科碩士班<br>97<br>Background and Purpose: Normal pressure hydrocephalus is one of the few causes of dementia that is potentially reversible or treatable. Timely diagnosis and placement of a ventriculoperitoneal shunt can lead to significant improvement. The cerebrospinal fluid (CSF) tap test remains one of the most reliable methods to predict the response of shunting. The aim of the study is to investigate (1) whether the rate of positive CSF tap test responders differ between the patients with idiopathic normal pressure hydrocephalus ( INPH ) and secondary normal pressure hy

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33

Beggs, Clive B. "Venous hemodynamics in neurological disorders: an analytical review with hydrodynamic analysis." 2013. http://hdl.handle.net/10454/9565.

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Yes<br>Venous abnormalities contribute to the pathophysiology of several neurological conditions. This paper reviews the literature regarding venous abnormalities in multiple sclerosis (MS), leukoaraiosis, and normal-pressure hydrocephalus (NPH). The review is supplemented with hydrodynamic analysis to assess the effects on cerebrospinal fluid (CSF) dynamics and cerebral blood flow (CBF) of venous hypertension in general, and chronic cerebrospinal venous insufficiency (CCSVI) in particular.CCSVI-like venous anomalies seem unlikely to account for reduced CBF in patients with MS, thus other mech

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34

Beggs, Clive B., Simon J. Shepherd, and P. Zamboni. "Cerebral venous outflow resistance and interpretation of cervical plethysmography data with respect to the diagnosis of chronic cerebrospinal venous insufficiency." 2014. http://hdl.handle.net/10454/10606.

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No<br>PURPOSE: To investigate cerebrospinal fluid (CSF) dynamics in the aqueduct of Sylvius (AoS) in chronic cerebrospinal venous insufficiency (CCSVI)-positive and -negative healthy individuals using cine phase contrast imaging. MATERIALS AND METHODS: Fifty-one healthy individuals (32 CCSVI-negative and 19 age-matched CCSVI-positive subjects) were examined using Doppler sonography (DS). Diagnosis of CCSVI was established if subjects fulfilled >/=2 venous hemodynamic criteria on DS. CSF flow and velocity measures were quantified using a semiautomated method and compared with clinical and routi

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