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Dissertations / Theses on the topic 'Hydrocortison'

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Published: 4 June 2021

Last updated: 14 February 2022

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1

Dagge, Alexander. "Hydrocortison in Stressdosierung, traumatische Erinnerungen und Posttraumatische Belastungsstörung." Diss., lmu, 2004. http://nbn-resolving.de/urn:nbn:de:bvb:19-23439.

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2

Graß, Corinna. "Reduziert Cortisol das Abrufinduzierte Vergessen? eine Doppelblindstudie /." [S.l. : s.n.], 2008. http://nbn-resolving.de/urn:nbn:de:bsz:352-opus-55086.

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3

Keh, Didier. "Hämodynamische und immunmodulatorische Effekte von niedrig dosiertem Hydrocortison im septischen Schock." [S.l.] : [s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=973452366.

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4

Keh, Didier. "Hämodynamische und immunmodulatorische Effekte von niedrig dosiertem Hydrocortison im septischen Schock." Doctoral thesis, Humboldt-Universität zu Berlin, Medizinische Fakultät - Universitätsklinikum Charité, 2004. http://dx.doi.org/10.18452/13955.

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In einer prospektiven, randomisierten, doppelblinden, Placebo-kontrollierten Cross-over-Studie wurden hämodynamische und immunologische Effekte einer dreitägigen adjunktiven Therapie mit niedrig dosiertem Hydrocortison (HC) (100 mg Bolus + 10 mg/Stunde) bei 40 Patienten im septischen Schock untersucht. Die Therapie mit HC führte zum Anstieg des mittleren arteriellen Drucks und des systemischen Gefäßwiderstands sowie zur Reduktion des Herzzeitvolumens und der Herzfrequenz, die pulmonalvaskulären Widerstände blieben unverändert. Die Nitrit/Nitrat-Plasmaspiegel (Stickstoffmonoxid-Synthese) und der Katecholaminverbrauch nahmen ab. Die Immunreaktionen waren komplex: Abnahme proinflammatorischer (Interleukin-(IL)-6, 8) und antiinflammatorischer (IL-10, lösliche Tumor-Nekrosefaktor-Rezeptoren) Mediatoren, Anstieg proinflammatorischer Zytokine (IL-12 und Interferon-?), Reduktion der Endothel- (E-Selektin) und Granulozytenaktivierung (CD11b, CD64), Reduktion der T-Helfer- und Suppressorzellzahl und der eosinophilen und basophilen Granulozyen, die Monozytenzahl stieg an und die neutrophilen Granulozyten sowie die Gesamtleukozytenzahl blieben unverändert. Parameter der unspezifischen (Respiratory Burst, Phagozytose) und der spezifischen Immunreaktion (HLA-DR auf Monozyten, Antigenpräsentation) wurden nicht oder nicht wesentlich supprimiert, die Phagozytosefähigkeit von Monozyten nahm zu. Eine Beendigung der HC-Therapie führte zu ausgeprägten hämodynamischen und immunologischen Rebound-Phänomenen. Die Wirkung von niedrig dosiertem HC im septischen Schock kann daher als kreislaufstabilisierend und immunmodulatorisch charakterisiert werden, Zeichen einer ausgeprägten Immunsuppression fanden sich nicht.<br>In a prospective, double-blind, randomised, placebo-controlled cross-over study, hemodynamic and immune effects of a three-day adjunctive treatment with low doses of hydrocortisone (HC) (100 mg bolus followed by 10 mg per hour) were investigated in forty patients with septic shock. HC-therapy induced a rise of mean arterial pressure and systemic vascular resistance and a decline of cardiac index and heart rate without altering pulmonary vascular resistance. Both, nitrite/nitrate levels (nitric oxide formation) and cathecholamine requirement were reduced. Immune responses were complex and included: reduction of proinflammatory (interleukin-(IL)-6, 8) and antiinflammatory (IL-10, soluble tumor necrosis factor receptors) mediators, an increase of proinflammatory cytokines (IL-12 and interferon-?), a reduction of endothelial (E-selectin) and granulocyte activation (CD11b, CD64), and a decrease of T-helper and suppressor cells as well as eosinophil and basophil granulocytes; monocytes increased and total granulocyte and leukocyte counts remained unaltered. Parameters of innate (respiratory burst, phagocytosis) and adaptive immune responses (HLA-DR-expression on monocytes, antigen presentation) were not essentially affected, monocyte phagocytosis rather increased. HC-withdrawal induced marked hemodynamic and immunologic rebound effects. In conclusion, effects of low dose HC-therapy in septic shock is characterised by hemodynamic stabilisation and immunomodulation, without inducing severe immunosuppression.

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5

Janele, David. "Effekte von Testosteron und 17beta-Östradiol auf die Zytokinsekretion peripherer humaner Leukozyten im Zusammenspiel mit Kortisol." kostenfrei, 2009. http://www.opus-bayern.de/uni-regensburg/volltexte/2009/1355/.

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6

Schwub, Degenhart. "Einfluss von Hydrocortison auf Zinkaufnahme und Zinkgehalt kultivierter Lungenzellen bei erhöhtem Zinkangebot /." München, 2008. http://opac.nebis.ch/cgi-bin/showAbstract.pl?sys=000253669.

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7

Schneeweiß, Johannes [Verfasser]. "Der Einfluss von Hydrocortison auf die Konsolidierung neutraler und emotionaler Gedächtnisinhalte / Johannes Schneeweiß." Lübeck : Zentrale Hochschulbibliothek Lübeck, 2011. http://d-nb.info/1010619586/34.

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8

Eck, Marleen Magdalena Margarethe van. "Stress, mood, and cortisol dynamics in daily life." [Maastricht : Maastricht : Universiteit Maastricht] ; University Library, Maastricht University [Host], 1996. http://arno.unimaas.nl/show.cgi?fid=6695.

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9

Dahler, Dominik Philemon. "Endokrinologische Korrelate der akuten Belastungssymptomatik nach Unfalltrauma." [S.l. : s.n.], 2005.

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10

Temrueck, Olga. "Einfluss von N-Acetylcystein auf die Toxizität von Zink in mit Hydrocortison vorbehandelten Typ 2 Alveolarepithelzelllinien." Diss., lmu, 2007. http://nbn-resolving.de/urn:nbn:de:bvb:19-78779.

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11

Reuter, Martin. "Cortisol und Emotion : ein experimentell-pharmakopsychologischer Forschungsansatz /." Hamburg : Kovac, 2001. http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&doc_number=009475198&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA.

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12

Appel, Daniel. "Biotransformation von 11-Desoxycortisol mit Schizosaccharomyces pombe und Aspergillus nidulans." [S.l. : s.n.], 2005. http://nbn-resolving.de/urn:nbn:de:bsz:93-opus-25224.

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13

Engelhardt, Tilmann [Verfasser]. "Der Einfluss von niedrig dosiertem Hydrocortison auf die Monozytenfunktion und HLA-DR Expression im septischen Schock / Tilmann Engelhardt." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2012. http://d-nb.info/1030382182/34.

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14

Schroeder, Henrike [Verfasser]. "Die Wirkung von Pentoxifyllin und Hydrocortison auf klinisch relevante Outcomevariablen nach kardiochirurgischen Eingriffen - eine retrospektive Untersuchung / Henrike Schroeder." Lübeck : Zentrale Hochschulbibliothek Lübeck, 2016. http://d-nb.info/109817061X/34.

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15

Gaßmann, Karin [Verfasser]. "Einfluss von Epinephrin und Hydrocortison auf die Insulinrezeptorregulation sowie die Tumornekrosefaktor-alpha- und Interleukin-10-Konzentration bei Gesunden / Karin Gaßmann." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2007. http://d-nb.info/102185591X/34.

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16

Schnelle, Kerstin [Verfasser], Tanja [Akademischer Betreuer] Lange, and Rolf [Gutachter] Verleger. "Der Einfluss von Hydrocortison auf die schlafassoziierte Konsolidierung deklarativer und prozeduraler Gedächtnisinhalte / Kerstin Schnelle ; Gutachter: Rolf Verleger ; Akademischer Betreuer: Tanja Lange." Lübeck : Zentrale Hochschulbibliothek Lübeck, 2020. http://d-nb.info/1207039098/34.

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17

Blacha, Antje K. [Verfasser], Birgit [Akademischer Betreuer] Harbeck, and Jürgen [Akademischer Betreuer] Koehler. "Einfluss einer Substitutionstherapie mit Hydrocortison auf die kognitive Leistungsfähigkeit von Patienten mit Nebenniereninsuffizienz / Antje K. Blacha ; Akademische Betreuer: Birgit Harbeck, Jürgen Koehler." Lübeck : Zentrale Hochschulbibliothek Lübeck, 2021. http://d-nb.info/1231031549/34.

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18

Grenz, Charlotte Denise [Verfasser], and Michael [Akademischer Betreuer] Hofbeck. "Sicherheit, Wirkung und Ansprechen einer Hydrocortison-Rescue-Therapie bei therapierefraktärer arterieller Hypotension nach Operation von Kindern mit angeborenem Herzfehler und kardiopulmonalem Bypass / Charlotte Denise Grenz ; Betreuer: Michael Hofbeck." Tübingen : Universitätsbibliothek Tübingen, 2018. http://d-nb.info/116872905X/34.

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19

Bonfig, Walter, Friedhelm Roehl, Stefan Riedl, et al. "Sodium Chloride Supplementation Is Not Routinely Performed in the Majority of German and Austrian Infants with Classic Salt-Wasting Congenital Adrenal Hyperplasia and Has No Effect on Linear Growth and Hydrocortisone or Fludrocortisone Dose." Karger, 2018. https://tud.qucosa.de/id/qucosa%3A70638.

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Introduction: Sodium chloride supplementation in saltwasting congenital adrenal hyperplasia (CAH) is generally recommended in infants, but its implementation in routine care is very heterogeneous. Objective: To evaluate oral sodium chloride supplementation, growth, and hydrocortisone and fludrocortisone dose in infants with salt-wasting CAH due to 21-hydroxylase in 311 infants from the AQUAPE CAH database. Results: Of 358 patients with classic CAH born between 1999 and 2015, 311 patients had salt-wasting CAH (133 females, 178 males). Of these, 86 patients (27.7%) received oral sodium chloride supplementation in a mean dose of 0.9 ± 1.4 mmol/kg/day (excluding nutritional sodium content) during the first year of life. 225 patients (72.3%) were not treated with sodium chloride. The percentage of sodium chloride-supplemented patients rose from 15.2% in children born 1999–2004 to 37.5% in children born 2011–2015. Sodium chloride-supplemented and -unsupplemented infants did not significantly differ in hydrocortisone and fludrocortisone dose, target height-corrected height-SDS, and BMI-SDS during the first 2 years of life. Conclusion: In the AQUAPE CAH database, approximately one-third of infants with salt-wasting CAH receive sodium chloride supplementation. Sodium chloride supplementation is performed more frequently in recent years. However, salt supplementation had no influence on growth, daily fludrocortisone and hydrocortisone dose, and frequency of adrenal crisis.

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20

WYTS, LAURENCE. "Aminoglutethimide et hydrocortisone dans les adenocarcinomes prostatiques." Lille 2, 1991. http://www.theses.fr/1991LIL2M333.

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21

Walser, Moritz, Rico Fischer, Thomas Goschke, Clemens Kirschbaum, and Franziska Plessow. "Intention Retrieval and Deactivation Following an Acute Psychosocial Stressor." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2014. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-133421.

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We often form intentions but have to postpone them until the appropriate situation for retrieval and execution has come, an ability also referred to as event-based prospective memory. After intention completion, our cognitive system has to deactivate no-more-relevant intention representations from memory to avoid interference with subsequent tasks. In everyday life, we frequently rely on these abilities also in stressful situations. Surprisingly, little is known about potential stress effects on these functions. Therefore, the present study aimed to examine the reliability of event-based prospective memory and of intention deactivation in conditions of acute psychosocial stress. To this aim, eighty-two participants underwent the Trier Social Stress Test, a standardized stress protocol, or a standardized control situation. Following this treatment, participants performed a computerized event-based prospective memory task with non-salient and focal prospective memory cues in order to assess prospective memory performance and deactivation of completed intentions. Although the stress group showed elevated levels of salivary cortisol as marker of a stress-related increase in hypothalamus-pituitary-adrenal axis activity throughout the cognitive testing period compared to the no-stress group, prospective memory performance and deactivation of completed intentions did not differ between groups. Findings indicate that cognitive control processes subserving intention retrieval and deactivation after completion may be mostly preserved even under conditions of acute stress.

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22

Garcia, Monica. "Differential Effects of Hydrocortisone on PTSD Symptom Clusters." Kent State University / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=kent1523196739368854.

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23

Walser, Moritz, Rico Fischer, Thomas Goschke, Clemens Kirschbaum, and Franziska Plessow. "Intention Retrieval and Deactivation Following an Acute Psychosocial Stressor." Public Library of Science, 2013. https://tud.qucosa.de/id/qucosa%3A27510.

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We often form intentions but have to postpone them until the appropriate situation for retrieval and execution has come, an ability also referred to as event-based prospective memory. After intention completion, our cognitive system has to deactivate no-more-relevant intention representations from memory to avoid interference with subsequent tasks. In everyday life, we frequently rely on these abilities also in stressful situations. Surprisingly, little is known about potential stress effects on these functions. Therefore, the present study aimed to examine the reliability of event-based prospective memory and of intention deactivation in conditions of acute psychosocial stress. To this aim, eighty-two participants underwent the Trier Social Stress Test, a standardized stress protocol, or a standardized control situation. Following this treatment, participants performed a computerized event-based prospective memory task with non-salient and focal prospective memory cues in order to assess prospective memory performance and deactivation of completed intentions. Although the stress group showed elevated levels of salivary cortisol as marker of a stress-related increase in hypothalamus-pituitary-adrenal axis activity throughout the cognitive testing period compared to the no-stress group, prospective memory performance and deactivation of completed intentions did not differ between groups. Findings indicate that cognitive control processes subserving intention retrieval and deactivation after completion may be mostly preserved even under conditions of acute stress.

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24

Hall, Clifford Michael. "Relative efficacy of hydrocortisone and methylprednisolone in acute severe asthma." Thesis, University of Cape Town, 1993. http://hdl.handle.net/11427/25562.

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25

Hamitouche, Noureddine. "Modélisation pharmacocinétique - pharmacodynamique de la fludrocotisone par approche de population." Thesis, Rennes 1, 2017. http://www.theses.fr/2017REN1B026/document.

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Introduction. Les corticoïdes sont supposés avoir des effets bénéfiques à faibles doses chez les patients en choc septique réfractaire. Ces effets ont été retrouvés dans plusieurs études utilisant l’hydrocortisone. Mais des données similaires n’existent cependant pas pour la fludrocortisone. Pourtant, l’hypothèse est que ces effets seraient liés en partie à l’action minéralocorticoïde. Or, la fludrocortisone est considérée comme un puissant minéralocorticoïde. Avant une éventuelle évaluation de la fludrocortisone chez les patients en choc septique, il est nécessaire dans un premier temps d’étudier sa pharmacocinétique (PK) et sa relation pharmacocinétique-pharmacodynamique (PK-PD) afin de mieux cerner ses effets et de sélectionner sa posologie efficace. Méthodes. Pour répondre aux objectifs, plusieurs travaux ont été réalisés. La modélisation en pharmacométrie par approche de population a été utilisée dans ces travaux pour caractériser la PK et la relation PK-PD de la fludrocortisone chez des volontaires sains après administration unique et répétée et la PK chez les patients en choc septique. Résultats. Chez les volontaires sains en administration unique seule ou en association avec l’hydrocortisone, la fludrocortisone a montré une demi-vie courte et proche de celle de l’hydrocortisone. Par ailleurs, la fludrocortisone présentait une puissance de l’effet minéralocorticoïde environ 200 fois plus importante que celle de l’hydrocortisone. Les simulations ont montré que la fludrocortisone nécessiterait d’être administrée à raison de quatre fois par jour. Chez les patients en choc septique, l’absorption de la fludrocortisone était très variable (7/21 des patients n’absorbaient pas la molécule) ce qui suggérait la nécessité de mettre au point une forme administrable par voie intraveineuse. A nouveau chez les volontaires sains mais en administration répétée pendant plusieurs jours, la fludrocortisone a montré une demi-vie et des paramètres pharmacocinétiques semblables à ceux retrouvés lors de la première étude et sur le plan pharmacodynamique, des effets hémodynamiques favorables (sur la réactivité vasculaire, la pression artérielle…) montrés pour la première fois avec cette molécule. Conclusion. La fludrocortisone a montré qu’elle pouvait induire les effets biologiques et hémodynamiques recherchés. Les effets hémodynamiques sur la réactivité vasculaire et la pression artérielle ont été observés après une imprégnation de 5 jours d’administration répétée de la fludrocortisone notamment avec la dose de 400 µg/jour. Une évaluation de l’efficacité de la fludrocortisone chez les patients en choc septique et maintenant envisageable et nécessaire pour confirmer les résultats obtenus<br>Introduction. Low doses of corticosteroids showed beneficial effects in septic shock patients. These favorable effects may be partly result from the stimulation of the mineralocorticoid receptors. This finding has led us to explore the pharmacokinetic and the effects on hemodynamic and biologic parameters of fludrocortisone which is a potent mineralocorticoid. Methods. In this work, a population approach modeling (nonlinear mixed effects modeling) was used to characterize the pharmacokinetic and the pharmacokinetic-pharmacodynamic relationship of fludrocortisone in healthy volunteers and the pharmacokinetic in septic shock patients. Results. In healthy volunteers after single oral administration alone or in combination with hydrocortisone, fludrocortisone 50 µg showed a short and similar plasma elimination half-life that intravenous hydrocortisone. Fludrocortisone plasma concentrations and effect on urinary sodium/potassium ratio had a higher inter-individual variability as compared to hydrocortisone. Simulations suggested that the administration regimen of fludrocortisone should be reconsidered. In septic shock patient, a single oral dose of fludrocortisone at 50 µg yielded detectable plasma drug concentrations in two-thirds of adults with septic shock. Fludrocortisone pharmacokinetics showed a short plasma elimination half-life and a large inter-individual variability. These results suggested that an intravenous formulation of fludrocortisone would be useful to reduce its pharmacokinetic variability in septic patients. In healthy volunteers again, after 5 days of repeated oral administration, fludrocortisone improved pressor response to phenylephrine. This effect was observed only at the dose of 400 µg/day, suggesting that fludrocortisone at higher doses than previously administered (50 µg/day) may be useful to be effective. Furthermore, we showed that fludrocortisone had a short plasma half-live (1.94 h) which is consistent with our previously published study. After 5 day of repeated administration, fludrocortisone significantly increased blood pressure. This effect was more marked at the dose of 400 µg/day. Conclusion. Our results argue in favor of potential beneficial effects that fludrocortisone could have in septic shock patients. An evaluation of the effectiveness of fludrocortisone in these patients is now possible and necessary to confirm our results

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26

Bosela, Ahmed Abdalla. "The effect of gamma-radiation on hydrocortisone in solutions and topical preparations." Thesis, University of Bath, 1987. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.377371.

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27

Gochenour, Lori L. "Cortisol responsivity association with fear and pain related to root canal therapy /." Morgantown, W. Va. : [West Virginia University Libraries], 2003. http://etd.wvu.edu/templates/showETD.cfm?recnum=2946.

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Thesis (M.S.)--West Virginia University, 2003.<br>Title from document title page. Document formatted into pages; contains ix, 57 p. : ill. (some col.). Vita. Includes abstract. Includes bibliographical references (p. 43-46).

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28

Schulz, Julia [Verfasser]. "Reduction in daily hydrocortisone dose improves bone health in primary adrenal insufficiency / Julia Schulz." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2017. http://d-nb.info/1126504254/34.

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29

Melin, Johanna [Verfasser]. "Pharmacometric approaches to assess hydrocortisone therapy in paediatric patients with adrenal insufficiency / Johanna Melin." Berlin : Freie Universität Berlin, 2018. http://d-nb.info/1176631810/34.

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30

Melin, Johanna Stina Elisabet [Verfasser]. "Pharmacometric approaches to assess hydrocortisone therapy in paediatric patients with adrenal insufficiency / Johanna Melin." Berlin : Freie Universität Berlin, 2018. http://d-nb.info/1176631810/34.

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31

Woods, Diana Lynn. "The effect of therapeutic touch on glucocortcoids and agitated behaviour in individuals with dementia of the Alzheimer type /." Thesis, Connect to this title online; UW restricted, 1999. http://hdl.handle.net/1773/7298.

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32

Webb, Patrick Thomas. "The Pre-Application of Hydrocortisone Cream and Its Effect on Transdermal Drug Delivery by Phonophoresis." BYU ScholarsArchive, 2012. https://scholarsarchive.byu.edu/etd/3935.

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Context: Transdermal delivery of hydrocortisone by phonophoresis is used for the treatment of musculoskeletal conditions. Research shows hydrocortisone and other white or opaque topical preparations transmit ultrasound energy poorly. Effective transmission of ultrasound is important in phonophoresis. Main Outcome measured: Samples of subcutaneous interstitial fluid were collected during and for 20 minutes following phonophoresis treatment. Cortisol concentrations were analyzed by an enzyme linked immune-assay (ELISA) test. Objective: Determine the subcutaneous cortisol concentration after two different phonophoresis treatments using a 2.5% hydrocortisone preparation. Design: Randomized design in which 22 healthy participants were assigned to receive a phonophoresis treatment where: 1) hydrocortisone cream was rubbed in completely prior to phonophoresis or 2) hydrocortisone powder was compounded with an ultrasound coupling gel. Test Subjects: 22 healthy individuals were recruited: 13 females with a mean age of 21 years and 9 males with a mean age of 21.8 years. Intervention: Phonophoresis consisted of pulsed ultrasound at 1 MHz, 1.0 w/cm2, and a 50% duty cycle. The treatment duration was 10 minutes and was localized over the distal gastrocnemius muscle. Results: We observed no significant difference in subcutaneous cortisol concentration between the two phonophoresis treatments (p=0.05). Also no significant difference was detected between pre and post-treatment cortisol levels within each individual treatment group. Conclusions: Our data indicates that completely rubbing a topical hydrocortisone application into the skin prior to placement of ultrasound gel does not result in increased transdermal delivery of cortisol when compared with the use of a compound of ultrasound gel and hydrocortisone powder applied topically to the skin.

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33

Kuchnia, Adam J. "Stress response and salivary cortisol levels in collegiate wrestlers." Online version, 2008. http://www.uwstout.edu/lib/thesis/2008/2008kuchniaa.pdf.

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34

Santema, Peter. "Conflict, cooperation and cortisol in meerkats." Thesis, University of Cambridge, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.608222.

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35

Loric, Sylvain. "Transcortine sérique : méthode de dosage par mesure de sa capacité de liaison pour le cortisol." Paris 5, 1989. http://www.theses.fr/1989PA05P151.

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36

Muller, Caroline. "Etude du mécanisme d'action anti-glucocorticoïde des dérivés 7-hydroxylés de la déhydroépiandrostérone." Paris, CNAM, 2006. http://www.theses.fr/2006CNAM0554.

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Des expériences de microscopie confocale réalisées dans la lignée cellulaire COS transfectée par le récepteur glucocorticoïde humain (hGR) ont montré que ni la déhydroépiandrostérone (DHEA) ni ses dérivés 7-hydroxylés ne modifient la localisation du récepteur et n'empêchent son transfert nucléaire. Ces stéroïdes sont également sans effet sur l'activité transactivatrice du hGR. La voie d’action génomique impliquant le hGR ne serait donc pas la cible de l’action de ces stéroïdes. Une analyse enzymologique des réactions catalysées par la 11β-hydroxystéroïde déshydrogénase 1 humaine (h11β-HSD1) exprimée dans la levure a mis en évidence une interconversion des métabolites de la DHEA, en parallèle de la réaction d’oxydo-réduction du cortisol et de la cortisone. Une compétition s’opère donc entre les glucocorticoïdes, immuno-suppresseurs, et les anti-glucocorticoïdes, immuno-stimulateurs, pour la liaison à la h11β-HSD1 au sein des tissus où coexistent ces deux types de substrats<br>Experiments with a confocal microscope with a COS cell line transfected with the human glucocorticoid receptor (hGR) showed that dehydroepiandrosterone (DHEA) and its 7-hydroxylated derivatives do not modify the location of the receptor and do not prevent the nuclear transfer of hGR. These steroids had no effect on the transactivation activity of hGR. Thus, these neurosteroids were inactive on this model and their genomic action through the GR could be excluded. The human 11β-hydroxysteroid dehydrogenase type 1 (h11β-HSD1) was expressed in the yeast and each of the enzyme-catalyzed reactions were analyzed. The inter-conversion of the 7-hydroxylated DHEA metabolites was demonstrated as well as the oxidoreduction of cortisol and cortisone. A competition for the binding with the h11β-HSD1 may take place between these steroids and the glucocorticoid activation process, the former triggering immunity and the latter suppressing it

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37

Laviolle, Bruno. "Pharmacologie de la fludrocortisone dans le choc septique." Rennes 1, 2011. http://www.theses.fr/2011REN1B144.

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L’intérêt des faibles doses d’hydrocortisone (HC) et de fludrocortisone (FC) dans le traitement du choc septique est aujourd’hui débattu. Nous avons évalué les effets biologiques de l’association HC+FC dans le choc septique, et les effets biologiques et hémodynamiques des deux molécules, administrées seules ou en association, chez le volontaire sain et chez le rat normal et en choc endotoxinique. Chez les malades en choc septique, l’association HC+FC a exercé les effets biologiques gluco- et minéralo-corticoïdes attendus parallèlement à leur effet bénéfique sur la mortalité. Chez le volontaire sain, en administration unique et aux doses utilisées dans le choc septique, l’HC a entraîné un effet minéralo-corticoïde plus marqué et plus précoce que la FC et a induit des effets hémodynamiques transitoires non retrouvés avec la FC, et l’HC et la FC ont diminué la réponse pressive à la phényléphrine avec un effet additif. Chez le rat, la FC et l’HC ont augmenté la pression artérielle, cet effet étant plus marqué chez les rats en choc endotoxinique que chez les rats normaux, et ont modifié la réactivité vasculaire d’anneaux d’artère mésentérique à la phényléphrine, le sens et l’amplitude de ces effets dépendant de la dose et des conditions expérimentales (animaux normaux ou en choc). La FC a montré qu’elle pouvait induire des effets biologiques et sur la réactivité vasculaire, chez le volontaire sain et le rat normal ou en choc endotoxinique, similaires à ceux de l’HC. Ces effets dépendent de la dose utilisée et des conditions expérimentales. Une recherche de la dose optimale à utiliser dans le choc septique semble aujourd’hui nécessaire avant de réévaluer son efficacité<br>The interest of low doses of hydrocortisone (HC) and fludrocortisone (FC) in the treatment of septic shock is controversial. We investigated the biological effects of the combination of HC+FC in septic shock, and the biological and hemodynamic effects of the two drugs, given alone or in combination, in healthy volunteers and in normal and endotoxemic rats. In septic shock patients, HC+FC induced the expected gluco- and mineralo-corticoid effects and these effects were observed simultaneously to the improvement of patient’s outcome. In healthy volunteers, using the same single doses than those used in septic shock, HC induced a more marked and earlier mineralo-corticoid effect than FC and induced transient hemodynamic effects whereas FC did not, and HC and FC decreased the pressor response to phenylephrine with additive effects. In rats, FC and HC increased blood pressure, this effect being more marked in endotoxemic than in normal rats, and modified the contractile response of mesenteric artery rings to phenylephrine, the direction and magnitude of these effects depending on the dose and experimental conditions (normal or endotoxemic animals). Our studies showed that FC could induce biological effects and modify vascular reactivity, in healthy volunteers and in normal and endotoxemic rats, in a similar way than HC. These effects depend on the dose and experimental conditions studied. Defining the optimal dose to be used in septic shock patients seems necessary before re-assessing its efficacy

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38

Mudyahoto, Nyengeterai Amanda. "Assessment of pharmaceutical equivalence of topical cream products containing hydrocortisone acetate using in vitro release testing (IVRT)." Thesis, Rhodes University, 2018. http://hdl.handle.net/10962/63384.

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39

Ratliff, Jeffrey. "The effects of anticipatory stress on analgesia and Cortisol concentrations in competitive athletes." Diss., Connect to the thesis, 2006. http://hdl.handle.net/10066/747.

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Dolich, Caryn Hurwitz Emily Nagle Sarah Ratliff Jeffrey. "The effects of anticipatory stress on pain threshold and Cortisol responses in male and female athletes." Diss., Connect to the thesis, 2006. http://hdl.handle.net/10066/746.

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Hurwitz, Emily. "Stress induced analgesia in competitive athletes." Diss., Connect to the thesis, 2006. http://hdl.handle.net/10066/736.

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Gastrich, Heidi J. "Allostasis and allostatic load reproducibility of cortisol excretion rates in women with and without family histories of breast cancer /." Diss., Online access via UMI:, 2007.

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43

Wells, Aaron M. "The Effects of Low Frequency Ultrasound in Transdermal Drug Delivery." BYU ScholarsArchive, 2010. https://scholarsarchive.byu.edu/etd/2560.

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Objective: Determine if varying ultrasound frequency affects the delivery of 10% hydrocortisone concentrations during phonophoresis. Utilize intramuscular microdialysis probe for drug collection, thus improving the experimental model. Methods: Thirty one (10 in groups 1 and 2, 11 in group 3) healthy subjects participated in this study. Interventions: Subjects were randomly assigned to one of three treatment groups receiving 10 minute ultrasound treatments applied to a standardized area of the gastrocnemius muscle of the right leg. The ultrasound was performed over the treated area using a 10% hydrocortisone compound mixed with standard ultrasound gel. The contralateral limb served as the control (no mixed compound or treatment) for all groups. Group one received sham ultrasound. Medicated gel was placed on the treatment site, the sound head moved, but no ultrasound was applied. Group two received 45 KHz at .056 w/cm2. Group three received 1 MHz at 1.0 w/cm2 at a 50 % duty cycle. Results: There was no difference in cortisol concentration change during treatment between the three treatment groups on the treated limbs (sham = 1.1 ±7.5 ng/ml, 45 KHz = 1.1 ± 1.5 ng/ml, 1 MHz = 4.1 ± 7.8 ng/ml; F2,22 = .34, P = .72) or control limbs (sham = 1.65 ± 6.6 ng/ml, 45 KHz = -1.3 ± 2.7 ng/ml, 1 MHz = 0.37 ± 8.1 ng/ml; F2,22 = .67, P = .546). No difference was found in cortisol concentration change during treatment between the treatment limbs and the control limbs (treatment = 2.1 ± 6.2 ng/ml, control = 0.20 ± 5.9 ng/ml; F1,22 = .9, P = .35). The following factors were found to influence cortisol concentrations levels in dialysate collected during treatment: depth of muscle in the treatment limbs (F1,22 = 6.4, P = .02), microdialysis probe depth in the control limbs (F1,22 = 4.1, P = .05), and pre treatment cortisol level in the control limbs (F1,22 = 10.1, P = .004. Conclusions: There was no evidence altering ultrasound frequency from 45 KHz to 1 MHZ enhanced the delivery of 10% hydrocortisone to treatment tissues under these experimental conditions.

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44

Lee, Wai Sin. "Effects of exogenous cortisol on the expression of cortisol and natriuretic peptide B receptors mRNA in gill epithelia of Japanese eels, Anguilla japonica." HKBU Institutional Repository, 2003. http://repository.hkbu.edu.hk/etd_ra/418.

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Normington, Charmaine. "Genotoxic effects of NSAIDs and hydrocortisone in bulk and nano forms in lymphocytes from patients with haematological cancers." Thesis, University of Bradford, 2017. http://hdl.handle.net/10454/17440.

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Chronic inflammation is intimately linked with cancer development and progression and therefore reducing or eliminating inflammation represents a logical treatment and prevention strategy. Studies have shown that anti-inflammatory agents have anti-tumour effects in cancers, with reduced metastases and mortality. Current use of anti-inflammatory agents in the treatment and prevention of cancer is limited by their toxicity and side effects. The emerging field of nanotechnology allows the fundamental properties of a drug to be altered, creating a product with improved reactivity and bioavailability, leading to more targeted treatments and reduced dosage. In the present study, the genotoxic effects of three commonly used anti-inflammatory drugs; aspirin, ibuprofen and hydrocortisone, in their bulk and nano forms were evaluated on peripheral blood lymphocytes of healthy donors using the comet assay and the micronucleus assay. In order to determine any anti-cancer effects, these agents were also tested in peripheral blood lymphocytes in patients with haematological cancers. The glucocorticoid hydrocortisone was also evaluated for anti-oxidant capacity. Our results demonstrate that the nano versions of each drug produced a different response than the bulk counterpart, indicating that a reduction in particle size had an impact on the reactivity of the drug. Our results also indicate that the nano versions of each drug were less genotoxic than the bulk formulation, further emphasising the potential of nanoparticles as an improvement to current treatment options. We also found an anti-oxidant effect with hydrocortisone, with a more profound effect seen with the nano formulation.

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Lewis, Erin Elizabeth. "Cortisol production during the strange situation differences between foster and comparison children /." Access to citation, abstract and download form provided by ProQuest Information and Learning Company; downloadable PDF file, 61 p, 2007. http://proquest.umi.com/pqdweb?did=1338922221&sid=19&Fmt=2&clientId=8331&RQT=309&VName=PQD.

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Martin, Björn Franklin. "The formulation and characterisation of corticosteroid loaded Ethosomes for topical delivery." University of the Western Cape, 2020. http://hdl.handle.net/11394/7922.

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Magister Pharmaceuticae - MPharm<br>Background/Introduction: Atopic dermatitis (AD) is one of the most prevalent diseases worldwide. It is a rapidly growing field of study with several research avenues to explore its pathophysiology and to find innovative treatment and management regimens. Clinically, it is classified as a non-contagious, intensely pruritic, inflammatory, chronic skin disorder mediated by abnormalities associated with atopy. Symptoms include inflammation, redness, pain and a negative impact on the patient‘s overall quality of life. Chronic itching often leads to the formation of lichenified skin, which may increase the thickness of the epidermis and exacerbate the barrier function of the skin. AD is treated with topical corticosteroids which help to decrease inflammation. However, lichification of the skin may decrease the efficacy of topical dosage forms. Nanomedicine is a rapidly developing field where advances have been made using ethosomes for topical delivery. As such, corticosteroid loaded ethosomal formulations containing hydrocortiosone acetate (HCA) and betamethasone valerate (BMV) were developed and characterised to develop novel tools for topical drug delivery. Aim: This study aimed at developing corticosteroid loaded ethosomes as a pre-formulation component for inclusion in a topical dosage form. To date, no ethosmal formulation with HCA and BMV has been investigated for topical drug delivery. Method: Ethosomes were synthesised using the hot method and the cold method, a modified version of a double emulsion (o/w/o), solvent evaporation technique, as developed by Touitou et al, 2007.1 Ethosomes were prepared using fixed concentrations of either BMV or HCA (10 mg/ml), ethanol (30% v/v) and purified water (70% v/v) and were comminuted using bath sonication or mini-extrusion. Centrifugation and centrifugal drying were used to purify and isolate the ethosomes for solid state characterisation. The morphology was determined using Scanning electron microscopy (SEM). Ethosomes were characterised using: dynamic light scattering (DLS), Fourier-transform infrared spectroscopy (FTIR), hot stage microscopy (HSM), differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA). The encapsulation efficiency (EE) and drug loading (DL) were determined using validated HPLC methods. Finally, the drug release was determined using Franz diffusion cells and mathematical models were fitted to the % cumulative release data to determine the release kinetics. Results: Ethosomes were assessed according to the following criteria for topical drug delivery which were determined using dynamic light scattering (DLS): Hydrodynamic diameter (HdD), ~ 200 nm, polydispersity index (PdI) < 0.5 and zeta potential (ζp) ± 30 mV. The optimum formulations contained phosphatidylcholine (PC) 50 mg/ml. Extrusion was found to be the best method for particle reduction based on the reproducibility of the results. The HdD was 163.8±31.99 and 147.7±19.91 for BMV loaded ethosomes and HCA loaded ethosomes respectively and both formulations had an acceptable PdI of 0.049 and 0.111, respectively. SEM analyses indicated that the ethosomes had a spherical shape. Encapsulation of the APIs was verified by the thermoanalyses and possible intermolecular interactions were identified using FTIR. BMV loaded and HCA loaded ethosomes had a respective EE of 74.57 % and 37.30 %, and a DL of 14.91 % and 7.46 %, respectively. The release kinetics best fit the Peppas-Sahlin model indicative of an anomalous non-Fickian diffusion coupled with polymer relaxation and zero order release. Conclusions: BMV and HCA loaded ethosomes for topical drug delivery were successfully synthesised and characterised. These novel nanoparticles have provided an array of avenues for further investigation and application in the topical delivery of corticosteroids

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KOHEK, MARIA B. da F. "Avaliacao da excrecao urinaria de cortisol por radioimunoensaio atraves de dois metodos (extraido e nao extraido)." reponame:Repositório Institucional do IPEN, 1992. http://repositorio.ipen.br:8080/xmlui/handle/123456789/10304.

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Made available in DSpace on 2014-10-09T12:37:07Z (GMT). No. of bitstreams: 0<br>Made available in DSpace on 2014-10-09T13:56:35Z (GMT). No. of bitstreams: 1 01915.pdf: 720683 bytes, checksum: 792e69704da8eebe940bb7946e887376 (MD5)<br>Dissertacao (Mestrado)<br>IPEN/D<br>Instituto de Pesquisas Energeticas e Nucleares - IPEN/CNEN-SP

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Filaire, Edith. "Influence de l'activité physique sur les réponses hormonales (cortisol et androgènes surrénaliens) chez la femme." Clermont-Ferrand 2, 1997. http://www.theses.fr/1997CLF20027.

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Le but de ce travail est l'étude de l'influence de l'activité sportive et du niveau de performance sur l'activité surrenalienne chez la femme. Notre population est composée de 36 sportives adultes reparties en 4 groupes : handballeuses nationales (n = 13), handballeuses régionales (n = 7), volleyeuses nationales (n = 7), volleyeuses régionales (n = 9), et d'un groupe témoin de 10 sédentaires. Des mesures anthropométriques ainsi que des mesures de vo#2 max. , des tests psychologiques et des dosages salivaires d'hormones ont été effectues a 4 reprises au cours d'une saison sportive de 4 mois. Les concentrations salivaires de cortisol, de dehydroepiandrosterone, d'androstenedione et de 11 hydroxyandrostenedione ont été determinées le matin, avant et après un exercice physique (session d'entrainement ou compétition) et le lendemain matin. Une activite sportive, même modérée, augmente les valeurs de repos des androgènes surrénaliens. Par contre, c'est seulement a partir d'un haut niveau de performance et/ou d'un volume d'entrainement élève qu'apparait une augmentation des concentrations de cortisol de repos. Le comportement du cortisol lors d'une session d'entrainement et lors d'une compétition officielle est fonction de la nature de l'activité pratique et/ou des traits psychologiques propres a chacune des populations. Les différences de réaction du cortisol entre une session d'entrainement et une compétition officielle sont les témoins de l'importance de la composante psychologique en compétition. La réactivite des androgènes surrénaliens lors d'un exercice physique (session d'entrainement, compétition) est en relation avec la nature même de l'activité pratique. La compétition induit un déséquilibre de la balance androgène/cortisol le jour de la compétition et lors de la récupération, l'activité androgénique étant plus sollicitée chez les volleyeuses.

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Del, Corral Salcedo Pedro. "Serum and salivary cortisol responses during aerobic exercise in children." Virtual Press, 1993. http://liblink.bsu.edu/uhtbin/catkey/879850.

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In adults, serum and salivary cortisol increase during aerobic exercise. There is little data on serum and no data on salivary cortisol responses during aerobic exercise in children. The purpose of this study was to examine serum and salivary cortisol during and after aerobic exercise. Ten male children with a mean age of 10.6 ± 0.6 years were subjects in this study. Each child came to the laboratory on three occasions. The first visit was to familiarize the child with the procedures. On the second visit, each child performed a maximal exercise test on a cycle ergometer (mean VO2. 49.5 ± 3.6 ml•kg''-min-') . On the third visit, an indwelling catheter was placed in a forearm vein. Thirty minutes later baseline blood and saliva samples were obtained followed by 30 minutes of exercise on a cycle ergometer at 69.5 ± 3.0% of VOA. Blood and saliva samples we e obtained at mid-exercise, end exercise and 15 minutes post-exercise. Serum and salivary cortisol were analyzed using RIA skit. Serum samples were corrected for changes in plasma volume. A repeated measures ANOVA revealed that exercise significantly increased serum, but not salivary cortisol. Mean salivary cortisol (ug.dl'') at baseline was 0.079 ± 0.042, at mid-exercise 0.099 ± 0.070, at end-exercise 0.133 ± 0.112, and at 15 minutes post-exercise was 0.143 ± 0.140. Post-hoc analyses indicated that mean serum cortisol at midexercise (7.94 ± 4.53 ug•dl-'), end-exercise (8.72 ± 5.61) and 15 minute post-exercise (8.21 ± 5.03 ug•dl'') were significantly greater than baseline (5.54 ± 2.73 ug•dl-'). The ratio of mean salivary to mean serum cortisol ranged from 1.3% to 1.7%. Serum and salivary cortisol were significantly correlated at mid-exercise (r=0.77), post-exercise (r=0.90) and 15 minutes post-exercise (r=0.84), but not at baseline. It is concluded that: (1) as a result -of exercise, children show adrenocortical activation as measured by serum cortisol; and, (2) salivary and serum cortisol are strongly correlated during and after exercise in children.<br>School of Physical Education

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