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WYTS, LAURENCE. "Aminoglutethimide et hydrocortisone dans les adenocarcinomes prostatiques." Lille 2, 1991. http://www.theses.fr/1991LIL2M333.
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Garcia, Monica. "Differential Effects of Hydrocortisone on PTSD Symptom Clusters." Kent State University / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=kent1523196739368854.
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Hamitouche, Noureddine. "Modélisation pharmacocinétique - pharmacodynamique de la fludrocotisone par approche de population." Thesis, Rennes 1, 2017. http://www.theses.fr/2017REN1B026/document.
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Introduction. Les corticoïdes sont supposés avoir des effets bénéfiques à faibles doses chez les patients en choc septique réfractaire. Ces effets ont été retrouvés dans plusieurs études utilisant l’hydrocortisone. Mais des données similaires n’existent cependant pas pour la fludrocortisone. Pourtant, l’hypothèse est que ces effets seraient liés en partie à l’action minéralocorticoïde. Or, la fludrocortisone est considérée comme un puissant minéralocorticoïde. Avant une éventuelle évaluation de la fludrocortisone chez les patients en choc septique, il est nécessaire dans un premier temps d’étudier sa pharmacocinétique (PK) et sa relation pharmacocinétique-pharmacodynamique (PK-PD) afin de mieux cerner ses effets et de sélectionner sa posologie efficace. Méthodes. Pour répondre aux objectifs, plusieurs travaux ont été réalisés. La modélisation en pharmacométrie par approche de population a été utilisée dans ces travaux pour caractériser la PK et la relation PK-PD de la fludrocortisone chez des volontaires sains après administration unique et répétée et la PK chez les patients en choc septique. Résultats. Chez les volontaires sains en administration unique seule ou en association avec l’hydrocortisone, la fludrocortisone a montré une demi-vie courte et proche de celle de l’hydrocortisone. Par ailleurs, la fludrocortisone présentait une puissance de l’effet minéralocorticoïde environ 200 fois plus importante que celle de l’hydrocortisone. Les simulations ont montré que la fludrocortisone nécessiterait d’être administrée à raison de quatre fois par jour. Chez les patients en choc septique, l’absorption de la fludrocortisone était très variable (7/21 des patients n’absorbaient pas la molécule) ce qui suggérait la nécessité de mettre au point une forme administrable par voie intraveineuse. A nouveau chez les volontaires sains mais en administration répétée pendant plusieurs jours, la fludrocortisone a montré une demi-vie et des paramètres pharmacocinétiques semblables à ceux retrouvés lors de la première étude et sur le plan pharmacodynamique, des effets hémodynamiques favorables (sur la réactivité vasculaire, la pression artérielle…) montrés pour la première fois avec cette molécule. Conclusion. La fludrocortisone a montré qu’elle pouvait induire les effets biologiques et hémodynamiques recherchés. Les effets hémodynamiques sur la réactivité vasculaire et la pression artérielle ont été observés après une imprégnation de 5 jours d’administration répétée de la fludrocortisone notamment avec la dose de 400 µg/jour. Une évaluation de l’efficacité de la fludrocortisone chez les patients en choc septique et maintenant envisageable et nécessaire pour confirmer les résultats obtenus<br>Introduction. Low doses of corticosteroids showed beneficial effects in septic shock patients. These favorable effects may be partly result from the stimulation of the mineralocorticoid receptors. This finding has led us to explore the pharmacokinetic and the effects on hemodynamic and biologic parameters of fludrocortisone which is a potent mineralocorticoid. Methods. In this work, a population approach modeling (nonlinear mixed effects modeling) was used to characterize the pharmacokinetic and the pharmacokinetic-pharmacodynamic relationship of fludrocortisone in healthy volunteers and the pharmacokinetic in septic shock patients. Results. In healthy volunteers after single oral administration alone or in combination with hydrocortisone, fludrocortisone 50 µg showed a short and similar plasma elimination half-life that intravenous hydrocortisone. Fludrocortisone plasma concentrations and effect on urinary sodium/potassium ratio had a higher inter-individual variability as compared to hydrocortisone. Simulations suggested that the administration regimen of fludrocortisone should be reconsidered. In septic shock patient, a single oral dose of fludrocortisone at 50 µg yielded detectable plasma drug concentrations in two-thirds of adults with septic shock. Fludrocortisone pharmacokinetics showed a short plasma elimination half-life and a large inter-individual variability. These results suggested that an intravenous formulation of fludrocortisone would be useful to reduce its pharmacokinetic variability in septic patients. In healthy volunteers again, after 5 days of repeated oral administration, fludrocortisone improved pressor response to phenylephrine. This effect was observed only at the dose of 400 µg/day, suggesting that fludrocortisone at higher doses than previously administered (50 µg/day) may be useful to be effective. Furthermore, we showed that fludrocortisone had a short plasma half-live (1.94 h) which is consistent with our previously published study. After 5 day of repeated administration, fludrocortisone significantly increased blood pressure. This effect was more marked at the dose of 400 µg/day. Conclusion. Our results argue in favor of potential beneficial effects that fludrocortisone could have in septic shock patients. An evaluation of the effectiveness of fludrocortisone in these patients is now possible and necessary to confirm our results
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Hall, Clifford Michael. "Relative efficacy of hydrocortisone and methylprednisolone in acute severe asthma." Thesis, University of Cape Town, 1993. http://hdl.handle.net/11427/25562.
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Bosela, Ahmed Abdalla. "The effect of gamma-radiation on hydrocortisone in solutions and topical preparations." Thesis, University of Bath, 1987. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.377371.
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Gochenour, Lori L. "Cortisol responsivity association with fear and pain related to root canal therapy /." Morgantown, W. Va. : [West Virginia University Libraries], 2003. http://etd.wvu.edu/templates/showETD.cfm?recnum=2946.
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Thesis (M.S.)--West Virginia University, 2003.<br>Title from document title page. Document formatted into pages; contains ix, 57 p. : ill. (some col.). Vita. Includes abstract. Includes bibliographical references (p. 43-46).
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Woods, Diana Lynn. "The effect of therapeutic touch on glucocortcoids and agitated behaviour in individuals with dementia of the Alzheimer type /." Thesis, Connect to this title online; UW restricted, 1999. http://hdl.handle.net/1773/7298.
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Santema, Peter. "Conflict, cooperation and cortisol in meerkats." Thesis, University of Cambridge, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.608222.
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Loric, Sylvain. "Transcortine sérique : méthode de dosage par mesure de sa capacité de liaison pour le cortisol." Paris 5, 1989. http://www.theses.fr/1989PA05P151.
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Muller, Caroline. "Etude du mécanisme d'action anti-glucocorticoïde des dérivés 7-hydroxylés de la déhydroépiandrostérone." Paris, CNAM, 2006. http://www.theses.fr/2006CNAM0554.
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Des expériences de microscopie confocale réalisées dans la lignée cellulaire COS transfectée par le récepteur glucocorticoïde humain (hGR) ont montré que ni la déhydroépiandrostérone (DHEA) ni ses dérivés 7-hydroxylés ne modifient la localisation du récepteur et n'empêchent son transfert nucléaire. Ces stéroïdes sont également sans effet sur l'activité transactivatrice du hGR. La voie d’action génomique impliquant le hGR ne serait donc pas la cible de l’action de ces stéroïdes. Une analyse enzymologique des réactions catalysées par la 11β-hydroxystéroïde déshydrogénase 1 humaine (h11β-HSD1) exprimée dans la levure a mis en évidence une interconversion des métabolites de la DHEA, en parallèle de la réaction d’oxydo-réduction du cortisol et de la cortisone. Une compétition s’opère donc entre les glucocorticoïdes, immuno-suppresseurs, et les anti-glucocorticoïdes, immuno-stimulateurs, pour la liaison à la h11β-HSD1 au sein des tissus où coexistent ces deux types de substrats<br>Experiments with a confocal microscope with a COS cell line transfected with the human glucocorticoid receptor (hGR) showed that dehydroepiandrosterone (DHEA) and its 7-hydroxylated derivatives do not modify the location of the receptor and do not prevent the nuclear transfer of hGR. These steroids had no effect on the transactivation activity of hGR. Thus, these neurosteroids were inactive on this model and their genomic action through the GR could be excluded. The human 11β-hydroxysteroid dehydrogenase type 1 (h11β-HSD1) was expressed in the yeast and each of the enzyme-catalyzed reactions were analyzed. The inter-conversion of the 7-hydroxylated DHEA metabolites was demonstrated as well as the oxidoreduction of cortisol and cortisone. A competition for the binding with the h11β-HSD1 may take place between these steroids and the glucocorticoid activation process, the former triggering immunity and the latter suppressing it
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Kuchnia, Adam J. "Stress response and salivary cortisol levels in collegiate wrestlers." Online version, 2008. http://www.uwstout.edu/lib/thesis/2008/2008kuchniaa.pdf.
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Webb, Patrick Thomas. "The Pre-Application of Hydrocortisone Cream and Its Effect on Transdermal Drug Delivery by Phonophoresis." BYU ScholarsArchive, 2012. https://scholarsarchive.byu.edu/etd/3935.
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Context: Transdermal delivery of hydrocortisone by phonophoresis is used for the treatment of musculoskeletal conditions. Research shows hydrocortisone and other white or opaque topical preparations transmit ultrasound energy poorly. Effective transmission of ultrasound is important in phonophoresis. Main Outcome measured: Samples of subcutaneous interstitial fluid were collected during and for 20 minutes following phonophoresis treatment. Cortisol concentrations were analyzed by an enzyme linked immune-assay (ELISA) test. Objective: Determine the subcutaneous cortisol concentration after two different phonophoresis treatments using a 2.5% hydrocortisone preparation. Design: Randomized design in which 22 healthy participants were assigned to receive a phonophoresis treatment where: 1) hydrocortisone cream was rubbed in completely prior to phonophoresis or 2) hydrocortisone powder was compounded with an ultrasound coupling gel. Test Subjects: 22 healthy individuals were recruited: 13 females with a mean age of 21 years and 9 males with a mean age of 21.8 years. Intervention: Phonophoresis consisted of pulsed ultrasound at 1 MHz, 1.0 w/cm2, and a 50% duty cycle. The treatment duration was 10 minutes and was localized over the distal gastrocnemius muscle. Results: We observed no significant difference in subcutaneous cortisol concentration between the two phonophoresis treatments (p=0.05). Also no significant difference was detected between pre and post-treatment cortisol levels within each individual treatment group. Conclusions: Our data indicates that completely rubbing a topical hydrocortisone application into the skin prior to placement of ultrasound gel does not result in increased transdermal delivery of cortisol when compared with the use of a compound of ultrasound gel and hydrocortisone powder applied topically to the skin.
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Melin, Johanna [Verfasser]. "Pharmacometric approaches to assess hydrocortisone therapy in paediatric patients with adrenal insufficiency / Johanna Melin." Berlin : Freie Universität Berlin, 2018. http://d-nb.info/1176631810/34.
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Melin, Johanna Stina Elisabet [Verfasser]. "Pharmacometric approaches to assess hydrocortisone therapy in paediatric patients with adrenal insufficiency / Johanna Melin." Berlin : Freie Universität Berlin, 2018. http://d-nb.info/1176631810/34.
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Schulz, Julia [Verfasser]. "Reduction in daily hydrocortisone dose improves bone health in primary adrenal insufficiency / Julia Schulz." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2017. http://d-nb.info/1126504254/34.
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Laviolle, Bruno. "Pharmacologie de la fludrocortisone dans le choc septique." Rennes 1, 2011. http://www.theses.fr/2011REN1B144.
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L’intérêt des faibles doses d’hydrocortisone (HC) et de fludrocortisone (FC) dans le traitement du choc septique est aujourd’hui débattu. Nous avons évalué les effets biologiques de l’association HC+FC dans le choc septique, et les effets biologiques et hémodynamiques des deux molécules, administrées seules ou en association, chez le volontaire sain et chez le rat normal et en choc endotoxinique. Chez les malades en choc septique, l’association HC+FC a exercé les effets biologiques gluco- et minéralo-corticoïdes attendus parallèlement à leur effet bénéfique sur la mortalité. Chez le volontaire sain, en administration unique et aux doses utilisées dans le choc septique, l’HC a entraîné un effet minéralo-corticoïde plus marqué et plus précoce que la FC et a induit des effets hémodynamiques transitoires non retrouvés avec la FC, et l’HC et la FC ont diminué la réponse pressive à la phényléphrine avec un effet additif. Chez le rat, la FC et l’HC ont augmenté la pression artérielle, cet effet étant plus marqué chez les rats en choc endotoxinique que chez les rats normaux, et ont modifié la réactivité vasculaire d’anneaux d’artère mésentérique à la phényléphrine, le sens et l’amplitude de ces effets dépendant de la dose et des conditions expérimentales (animaux normaux ou en choc). La FC a montré qu’elle pouvait induire des effets biologiques et sur la réactivité vasculaire, chez le volontaire sain et le rat normal ou en choc endotoxinique, similaires à ceux de l’HC. Ces effets dépendent de la dose utilisée et des conditions expérimentales. Une recherche de la dose optimale à utiliser dans le choc septique semble aujourd’hui nécessaire avant de réévaluer son efficacité<br>The interest of low doses of hydrocortisone (HC) and fludrocortisone (FC) in the treatment of septic shock is controversial. We investigated the biological effects of the combination of HC+FC in septic shock, and the biological and hemodynamic effects of the two drugs, given alone or in combination, in healthy volunteers and in normal and endotoxemic rats. In septic shock patients, HC+FC induced the expected gluco- and mineralo-corticoid effects and these effects were observed simultaneously to the improvement of patient’s outcome. In healthy volunteers, using the same single doses than those used in septic shock, HC induced a more marked and earlier mineralo-corticoid effect than FC and induced transient hemodynamic effects whereas FC did not, and HC and FC decreased the pressor response to phenylephrine with additive effects. In rats, FC and HC increased blood pressure, this effect being more marked in endotoxemic than in normal rats, and modified the contractile response of mesenteric artery rings to phenylephrine, the direction and magnitude of these effects depending on the dose and experimental conditions (normal or endotoxemic animals). Our studies showed that FC could induce biological effects and modify vascular reactivity, in healthy volunteers and in normal and endotoxemic rats, in a similar way than HC. These effects depend on the dose and experimental conditions studied. Defining the optimal dose to be used in septic shock patients seems necessary before re-assessing its efficacy
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Ratliff, Jeffrey. "The effects of anticipatory stress on analgesia and Cortisol concentrations in competitive athletes." Diss., Connect to the thesis, 2006. http://hdl.handle.net/10066/747.
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Dolich, Caryn Hurwitz Emily Nagle Sarah Ratliff Jeffrey. "The effects of anticipatory stress on pain threshold and Cortisol responses in male and female athletes." Diss., Connect to the thesis, 2006. http://hdl.handle.net/10066/746.
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Hurwitz, Emily. "Stress induced analgesia in competitive athletes." Diss., Connect to the thesis, 2006. http://hdl.handle.net/10066/736.
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Gastrich, Heidi J. "Allostasis and allostatic load reproducibility of cortisol excretion rates in women with and without family histories of breast cancer /." Diss., Online access via UMI:, 2007.
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Lee, Wai Sin. "Effects of exogenous cortisol on the expression of cortisol and natriuretic peptide B receptors mRNA in gill epithelia of Japanese eels, Anguilla japonica." HKBU Institutional Repository, 2003. http://repository.hkbu.edu.hk/etd_ra/418.
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Wells, Aaron M. "The Effects of Low Frequency Ultrasound in Transdermal Drug Delivery." BYU ScholarsArchive, 2010. https://scholarsarchive.byu.edu/etd/2560.
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Objective: Determine if varying ultrasound frequency affects the delivery of 10% hydrocortisone concentrations during phonophoresis. Utilize intramuscular microdialysis probe for drug collection, thus improving the experimental model. Methods: Thirty one (10 in groups 1 and 2, 11 in group 3) healthy subjects participated in this study. Interventions: Subjects were randomly assigned to one of three treatment groups receiving 10 minute ultrasound treatments applied to a standardized area of the gastrocnemius muscle of the right leg. The ultrasound was performed over the treated area using a 10% hydrocortisone compound mixed with standard ultrasound gel. The contralateral limb served as the control (no mixed compound or treatment) for all groups. Group one received sham ultrasound. Medicated gel was placed on the treatment site, the sound head moved, but no ultrasound was applied. Group two received 45 KHz at .056 w/cm2. Group three received 1 MHz at 1.0 w/cm2 at a 50 % duty cycle. Results: There was no difference in cortisol concentration change during treatment between the three treatment groups on the treated limbs (sham = 1.1 ±7.5 ng/ml, 45 KHz = 1.1 ± 1.5 ng/ml, 1 MHz = 4.1 ± 7.8 ng/ml; F2,22 = .34, P = .72) or control limbs (sham = 1.65 ± 6.6 ng/ml, 45 KHz = -1.3 ± 2.7 ng/ml, 1 MHz = 0.37 ± 8.1 ng/ml; F2,22 = .67, P = .546). No difference was found in cortisol concentration change during treatment between the treatment limbs and the control limbs (treatment = 2.1 ± 6.2 ng/ml, control = 0.20 ± 5.9 ng/ml; F1,22 = .9, P = .35). The following factors were found to influence cortisol concentrations levels in dialysate collected during treatment: depth of muscle in the treatment limbs (F1,22 = 6.4, P = .02), microdialysis probe depth in the control limbs (F1,22 = 4.1, P = .05), and pre treatment cortisol level in the control limbs (F1,22 = 10.1, P = .004. Conclusions: There was no evidence altering ultrasound frequency from 45 KHz to 1 MHZ enhanced the delivery of 10% hydrocortisone to treatment tissues under these experimental conditions.
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Lewis, Erin Elizabeth. "Cortisol production during the strange situation differences between foster and comparison children /." Access to citation, abstract and download form provided by ProQuest Information and Learning Company; downloadable PDF file, 61 p, 2007. http://proquest.umi.com/pqdweb?did=1338922221&sid=19&Fmt=2&clientId=8331&RQT=309&VName=PQD.
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KOHEK, MARIA B. da F. "Avaliacao da excrecao urinaria de cortisol por radioimunoensaio atraves de dois metodos (extraido e nao extraido)." reponame:Repositório Institucional do IPEN, 1992. http://repositorio.ipen.br:8080/xmlui/handle/123456789/10304.
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Martin, Björn Franklin. "The formulation and characterisation of corticosteroid loaded Ethosomes for topical delivery." University of the Western Cape, 2020. http://hdl.handle.net/11394/7922.
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Magister Pharmaceuticae - MPharm<br>Background/Introduction: Atopic dermatitis (AD) is one of the most prevalent diseases worldwide. It is a rapidly growing field of study with several research avenues to explore its pathophysiology and to find innovative treatment and management regimens. Clinically, it is classified as a non-contagious, intensely pruritic, inflammatory, chronic skin disorder mediated by abnormalities associated with atopy. Symptoms include inflammation, redness, pain and a negative impact on the patient‘s overall quality of life. Chronic itching often leads to the formation of lichenified skin, which may increase the thickness of the epidermis and exacerbate the barrier function of the skin. AD is treated with topical corticosteroids which help to decrease inflammation. However, lichification of the skin may decrease the efficacy of topical dosage forms. Nanomedicine is a rapidly developing field where advances have been made using ethosomes for topical delivery. As such, corticosteroid loaded ethosomal formulations containing hydrocortiosone acetate (HCA) and betamethasone valerate (BMV) were developed and characterised to develop novel tools for topical drug delivery. Aim: This study aimed at developing corticosteroid loaded ethosomes as a pre-formulation component for inclusion in a topical dosage form. To date, no ethosmal formulation with HCA and BMV has been investigated for topical drug delivery. Method: Ethosomes were synthesised using the hot method and the cold method, a modified version of a double emulsion (o/w/o), solvent evaporation technique, as developed by Touitou et al, 2007.1 Ethosomes were prepared using fixed concentrations of either BMV or HCA (10 mg/ml), ethanol (30% v/v) and purified water (70% v/v) and were comminuted using bath sonication or mini-extrusion. Centrifugation and centrifugal drying were used to purify and isolate the ethosomes for solid state characterisation. The morphology was determined using Scanning electron microscopy (SEM). Ethosomes were characterised using: dynamic light scattering (DLS), Fourier-transform infrared spectroscopy (FTIR), hot stage microscopy (HSM), differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA). The encapsulation efficiency (EE) and drug loading (DL) were determined using validated HPLC methods. Finally, the drug release was determined using Franz diffusion cells and mathematical models were fitted to the % cumulative release data to determine the release kinetics. Results: Ethosomes were assessed according to the following criteria for topical drug delivery which were determined using dynamic light scattering (DLS): Hydrodynamic diameter (HdD), ~ 200 nm, polydispersity index (PdI) < 0.5 and zeta potential (ζp) ± 30 mV. The optimum formulations contained phosphatidylcholine (PC) 50 mg/ml. Extrusion was found to be the best method for particle reduction based on the reproducibility of the results. The HdD was 163.8±31.99 and 147.7±19.91 for BMV loaded ethosomes and HCA loaded ethosomes respectively and both formulations had an acceptable PdI of 0.049 and 0.111, respectively. SEM analyses indicated that the ethosomes had a spherical shape. Encapsulation of the APIs was verified by the thermoanalyses and possible intermolecular interactions were identified using FTIR. BMV loaded and HCA loaded ethosomes had a respective EE of 74.57 % and 37.30 %, and a DL of 14.91 % and 7.46 %, respectively. The release kinetics best fit the Peppas-Sahlin model indicative of an anomalous non-Fickian diffusion coupled with polymer relaxation and zero order release. Conclusions: BMV and HCA loaded ethosomes for topical drug delivery were successfully synthesised and characterised. These novel nanoparticles have provided an array of avenues for further investigation and application in the topical delivery of corticosteroids
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Filaire, Edith. "Influence de l'activité physique sur les réponses hormonales (cortisol et androgènes surrénaliens) chez la femme." Clermont-Ferrand 2, 1997. http://www.theses.fr/1997CLF20027.
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Le but de ce travail est l'étude de l'influence de l'activité sportive et du niveau de performance sur l'activité surrenalienne chez la femme. Notre population est composée de 36 sportives adultes reparties en 4 groupes : handballeuses nationales (n = 13), handballeuses régionales (n = 7), volleyeuses nationales (n = 7), volleyeuses régionales (n = 9), et d'un groupe témoin de 10 sédentaires. Des mesures anthropométriques ainsi que des mesures de vo#2 max. , des tests psychologiques et des dosages salivaires d'hormones ont été effectues a 4 reprises au cours d'une saison sportive de 4 mois. Les concentrations salivaires de cortisol, de dehydroepiandrosterone, d'androstenedione et de 11 hydroxyandrostenedione ont été determinées le matin, avant et après un exercice physique (session d'entrainement ou compétition) et le lendemain matin. Une activite sportive, même modérée, augmente les valeurs de repos des androgènes surrénaliens. Par contre, c'est seulement a partir d'un haut niveau de performance et/ou d'un volume d'entrainement élève qu'apparait une augmentation des concentrations de cortisol de repos. Le comportement du cortisol lors d'une session d'entrainement et lors d'une compétition officielle est fonction de la nature de l'activité pratique et/ou des traits psychologiques propres a chacune des populations. Les différences de réaction du cortisol entre une session d'entrainement et une compétition officielle sont les témoins de l'importance de la composante psychologique en compétition. La réactivite des androgènes surrénaliens lors d'un exercice physique (session d'entrainement, compétition) est en relation avec la nature même de l'activité pratique. La compétition induit un déséquilibre de la balance androgène/cortisol le jour de la compétition et lors de la récupération, l'activité androgénique étant plus sollicitée chez les volleyeuses.
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Mudyahoto, Nyengeterai Amanda. "Assessment of pharmaceutical equivalence of topical cream products containing hydrocortisone acetate using in vitro release testing (IVRT)." Thesis, Rhodes University, 2018. http://hdl.handle.net/10962/63384.
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Del, Corral Salcedo Pedro. "Serum and salivary cortisol responses during aerobic exercise in children." Virtual Press, 1993. http://liblink.bsu.edu/uhtbin/catkey/879850.
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In adults, serum and salivary cortisol increase during aerobic exercise. There is little data on serum and no data on salivary cortisol responses during aerobic exercise in children. The purpose of this study was to examine serum and salivary cortisol during and after aerobic exercise. Ten male children with a mean age of 10.6 ± 0.6 years were subjects in this study. Each child came to the laboratory on three occasions. The first visit was to familiarize the child with the procedures. On the second visit, each child performed a maximal exercise test on a cycle ergometer (mean VO2. 49.5 ± 3.6 ml•kg''-min-') . On the third visit, an indwelling catheter was placed in a forearm vein. Thirty minutes later baseline blood and saliva samples were obtained followed by 30 minutes of exercise on a cycle ergometer at 69.5 ± 3.0% of VOA. Blood and saliva samples we e obtained at mid-exercise, end exercise and 15 minutes post-exercise. Serum and salivary cortisol were analyzed using RIA skit. Serum samples were corrected for changes in plasma volume. A repeated measures ANOVA revealed that exercise significantly increased serum, but not salivary cortisol. Mean salivary cortisol (ug.dl'') at baseline was 0.079 ± 0.042, at mid-exercise 0.099 ± 0.070, at end-exercise 0.133 ± 0.112, and at 15 minutes post-exercise was 0.143 ± 0.140. Post-hoc analyses indicated that mean serum cortisol at midexercise (7.94 ± 4.53 ug•dl-'), end-exercise (8.72 ± 5.61) and 15 minute post-exercise (8.21 ± 5.03 ug•dl'') were significantly greater than baseline (5.54 ± 2.73 ug•dl-'). The ratio of mean salivary to mean serum cortisol ranged from 1.3% to 1.7%. Serum and salivary cortisol were significantly correlated at mid-exercise (r=0.77), post-exercise (r=0.90) and 15 minutes post-exercise (r=0.84), but not at baseline. It is concluded that: (1) as a result -of exercise, children show adrenocortical activation as measured by serum cortisol; and, (2) salivary and serum cortisol are strongly correlated during and after exercise in children.<br>School of Physical Education
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PORTUGAL, HENRI. "Dosage spectrofluorimetrique de quatre corticoides anti-inflammatoires." Aix-Marseille 2, 1989. http://www.theses.fr/1989AIX22976.
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Williams, Evan, and Jacob Dale Stearley. "Physicochemical Properties of a ‘Magic Mouthwash’ for Chemotherapy Induced Oral Mucositis." The University of Arizona, 2011. http://hdl.handle.net/10150/623534.
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Class of 2011 Abstract<br>OBJECTIVES: To determine the solubility and stability of hydrocortisone in a ‘magic mouthwash; suspension. METHODS: A literature review was conducted to establish the most common ingredients in a ‘magic mouthwash’ suspension It was decided that the test suspension would consist of 75% commercially available diphenhydramine solution, 12.5% nystatin suspension (100,000 units/ml) , and 12.5% lidocaine solution (2% lidocaine). Powdered hydrocortisone was then added to the test suspensions at different concentrations and stored at 27C, 38C, and 48C. Aliquots were taken from each of the test samples at the time of compounding and at 4, 7, 13, 19, and 26 days to be analyzed by HPLC for degradation of hydrocortisone and percent hydrocortisone in suspension. RESULTS: At 27C, 98.5% of hydrocortisone was recovered after 26 days, versus 33.7% at 38C, and 7% at 48C. The solubility of hydrocortisone in the suspension was higher at higher temperatures, with 82% in solution at 48C, 70% at 38C, and 38% at 27C.
CONCLUSION: The amount of hydrocortisone recovered deteriorated over time and at higher temperatures, and solubility of hydrocortisone in the suspension was greater at higher temperatures.
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Penza, Kristin Marie. "Cortisol recovery from stress : the roles of childhood abuse, recent adversity, and affect among depressed and never-depressed women /." view abstract or download file of text, 2002. http://wwwlib.umi.com/cr/uoregon/fullcit?p3072601.
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Thesis (Ph. D.)--University of Oregon, 2002.<br>Typescript. Includes vita and abstract. Includes bibliographical references (leaves 125-137). Also available for download via the World Wide Web; free to University of Oregon users.
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Keh, Didier. "Hämodynamische und immunmodulatorische Effekte von niedrig dosiertem Hydrocortison im septischen Schock." Doctoral thesis, Humboldt-Universität zu Berlin, Medizinische Fakultät - Universitätsklinikum Charité, 2004. http://dx.doi.org/10.18452/13955.
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In einer prospektiven, randomisierten, doppelblinden, Placebo-kontrollierten Cross-over-Studie wurden hämodynamische und immunologische Effekte einer dreitägigen adjunktiven Therapie mit niedrig dosiertem Hydrocortison (HC) (100 mg Bolus + 10 mg/Stunde) bei 40 Patienten im septischen Schock untersucht. Die Therapie mit HC führte zum Anstieg des mittleren arteriellen Drucks und des systemischen Gefäßwiderstands sowie zur Reduktion des Herzzeitvolumens und der Herzfrequenz, die pulmonalvaskulären Widerstände blieben unverändert. Die Nitrit/Nitrat-Plasmaspiegel (Stickstoffmonoxid-Synthese) und der Katecholaminverbrauch nahmen ab. Die Immunreaktionen waren komplex: Abnahme proinflammatorischer (Interleukin-(IL)-6, 8) und antiinflammatorischer (IL-10, lösliche Tumor-Nekrosefaktor-Rezeptoren) Mediatoren, Anstieg proinflammatorischer Zytokine (IL-12 und Interferon-?), Reduktion der Endothel- (E-Selektin) und Granulozytenaktivierung (CD11b, CD64), Reduktion der T-Helfer- und Suppressorzellzahl und der eosinophilen und basophilen Granulozyen, die Monozytenzahl stieg an und die neutrophilen Granulozyten sowie die Gesamtleukozytenzahl blieben unverändert. Parameter der unspezifischen (Respiratory Burst, Phagozytose) und der spezifischen Immunreaktion (HLA-DR auf Monozyten, Antigenpräsentation) wurden nicht oder nicht wesentlich supprimiert, die Phagozytosefähigkeit von Monozyten nahm zu. Eine Beendigung der HC-Therapie führte zu ausgeprägten hämodynamischen und immunologischen Rebound-Phänomenen. Die Wirkung von niedrig dosiertem HC im septischen Schock kann daher als kreislaufstabilisierend und immunmodulatorisch charakterisiert werden, Zeichen einer ausgeprägten Immunsuppression fanden sich nicht.<br>In a prospective, double-blind, randomised, placebo-controlled cross-over study, hemodynamic and immune effects of a three-day adjunctive treatment with low doses of hydrocortisone (HC) (100 mg bolus followed by 10 mg per hour) were investigated in forty patients with septic shock. HC-therapy induced a rise of mean arterial pressure and systemic vascular resistance and a decline of cardiac index and heart rate without altering pulmonary vascular resistance. Both, nitrite/nitrate levels (nitric oxide formation) and cathecholamine requirement were reduced. Immune responses were complex and included: reduction of proinflammatory (interleukin-(IL)-6, 8) and antiinflammatory (IL-10, soluble tumor necrosis factor receptors) mediators, an increase of proinflammatory cytokines (IL-12 and interferon-?), a reduction of endothelial (E-selectin) and granulocyte activation (CD11b, CD64), and a decrease of T-helper and suppressor cells as well as eosinophil and basophil granulocytes; monocytes increased and total granulocyte and leukocyte counts remained unaltered. Parameters of innate (respiratory burst, phagocytosis) and adaptive immune responses (HLA-DR-expression on monocytes, antigen presentation) were not essentially affected, monocyte phagocytosis rather increased. HC-withdrawal induced marked hemodynamic and immunologic rebound effects. In conclusion, effects of low dose HC-therapy in septic shock is characterised by hemodynamic stabilisation and immunomodulation, without inducing severe immunosuppression.
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Normington, Charmaine. "Genotoxic effects of NSAIDs and hydrocortisone in bulk and nano forms in lymphocytes from patients with haematological cancers." Thesis, University of Bradford, 2017. http://hdl.handle.net/10454/17440.
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Chronic inflammation is intimately linked with cancer development and progression and therefore reducing or eliminating inflammation represents a logical treatment and prevention strategy. Studies have shown that anti-inflammatory agents have anti-tumour effects in cancers, with reduced metastases and mortality. Current use of anti-inflammatory agents in the treatment and prevention of cancer is limited by their toxicity and side effects. The emerging field of nanotechnology allows the fundamental properties of a drug to be altered, creating a product with improved reactivity and bioavailability, leading to more targeted treatments and reduced dosage. In the present study, the genotoxic effects of three commonly used anti-inflammatory drugs; aspirin, ibuprofen and hydrocortisone, in their bulk and nano forms were evaluated on peripheral blood lymphocytes of healthy donors using the comet assay and the micronucleus assay. In order to determine any anti-cancer effects, these agents were also tested in peripheral blood lymphocytes in patients with haematological cancers. The glucocorticoid hydrocortisone was also evaluated for anti-oxidant capacity. Our results demonstrate that the nano versions of each drug produced a different response than the bulk counterpart, indicating that a reduction in particle size had an impact on the reactivity of the drug. Our results also indicate that the nano versions of each drug were less genotoxic than the bulk formulation, further emphasising the potential of nanoparticles as an improvement to current treatment options. We also found an anti-oxidant effect with hydrocortisone, with a more profound effect seen with the nano formulation.
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Aardal-Eriksson, Elisabeth. "Salivary cortisol and posttraumatic stress reactions : methodological and applied studies before and after trauma /." Linköping : Univ, 2002. http://www.bibl.liu.se/liupubl/disp/disp2002/med705s.pdf.
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Pilgrim, Kamala. "Mechanisms underlying cortisol reactivity to stress in low and high socioeconomic status individuals : role of naturally-occurring attentional biases." Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=116040.
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This Master's dissertation explored whether a rapid orienting of attention toward or away from social stress information during a restful state, relates to the magnitude of glucocorticoids (GC) released in response to a stressor, the Trier Social Stress Test (TSST). It also assessed whether childhood rearing in a low socioeconomic status (SES) context mediates this relationship. Subjects rested for 45 minutes during which time they completed a modified version of Posner's attention paradigm, comprising social stress words. Immediately following, participants were exposed to the stressor. Results indicated that a rapid attentional engagement toward social stress words associated with pronounced GC responses to the TSST. Fast engagers displayed lower self-esteem and did not differ in terms of their past SES. These findings demonstrate that attentional biases for social stress information at rest combine with diminished self-esteem to predict the magnitude of GC released during psychological stress irrespective of early SES conditions.
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Steele, Amber. "Cortisol and mood as a function of luteal progesterone change : a prospective cohort study in Cambridge using diary methods and biological samples." Thesis, University of Cambridge, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.610359.
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Joannidis, S. "Effets de la substitution glucocorticoide sur la fonction thyreotrope dans les atteintes hypothalamo-hypophysaires : interet de l'etude du rythme circadien de la tsh." Lille 2, 1989. http://www.theses.fr/1989LIL2M092.
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GUIGNON, IRMINE. "Effets de l'hemisuccinate d'hydrocortisone sur la dyspnee chez des patients emphysemateux en etat stable." Aix-Marseille 2, 1993. http://www.theses.fr/1993AIX20842.
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Mathieu, Annie. "Rôle de la luminosité et du taux de cortisol dans l'agitation motrice de personnes atteintes de démence vivant en hébergement." Sherbrooke : Université de Sherbrooke, 2002.
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Oxford, Jonathan K. Geary David C. "Testosterone and cortisol in coalitional competition." Diss., Columbia, Mo. : University of Missouri--Columbia, 2008. http://hdl.handle.net/10355/5728.
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The entire thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file; a non-technical public abstract appears in the public.pdf file. Title from PDF of title page (University of Missouri--Columbia, viewed on October 2, 2009). Thesis advisor: Dr. David C. Geary. Includes bibliographical references.
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Toumi, Mondher. "Modulation pharmacologique de la dyspnee chez l'asthmatique." Aix-Marseille 2, 1993. http://www.theses.fr/1993AIX20114.
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Robertson, Dylan. "Hydrocortisone and TGF-ß1 regulate the glucocorticoid receptor and the serotonin transporter in SWAN-71 and JEG-3 cells." Thesis, Griffith University, 2019. http://hdl.handle.net/10072/386033.
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Introduction
Pregnancy-related disorders such as pre-eclampsia (PE), intrauterine growth restriction (IUGR), and pre-term birth (PTB) significantly contribute to maternal and fetal morbidity and mortality in all human societies. Each of these conditions can result from placental insufficiency, a pathophysiological condition affecting the placenta due to trophoblast dysfunction. Maternal complications during pregnancy such as gestational diabetes mellitus (GDM) and perinatal depression (PD) show significant associations with these placental pathologies. Perturbations in stress and inflammatory mediators, cortisol and TGF-β1, as well as the serotonin transporter of the serotonin system, have been associated with abnormal properties of trophoblast function including proliferation, migration, invasion, and remodelling which underpin trophoblast dysfunction and incomplete placentation. While glucocorticoid signalling, TGF-β1 signal transduction, and the serotonin system have been implicated in the aetiologies of these pathological conditions, their interactions have been seldom explored in placental cell models.
Experimental aims
The aim of the present study was to investigate the effects of stress and inflammatory mediators, cortisol and TGF-β1, on cell metabolic activity and cytotoxicity measured using the MTT and LDH assays, protein expression of glucocorticoid receptor isoforms and the serotonin transporter measured using Western blot analysis, as well as mRNA expression of the glucocorticoid receptor measured using NanoString nCounter analysis in placental cell lines, SWAN-71 and JEG-3. The purpose of these experiments was to elucidate the relationships between stress, inflammation, and the serotonin system in trophoblast pathophysiology and possible involvement in the aetiologies of PE, IUGR, and PTB.
Methods
SWAN-71 and JEG-3 cell lines were chosen as placental cell models for the present study. MTT and LDH assays were carried out to determine the effects of the proposed pharmacological treatments – hydrocortisone, mifepristone, TGF-β1, and SB431542 – may have on cell viability. Cells were treated with hydrocortisone (500 nM and 1 μM), mifepristone (10 nM), TGF-β1 (5 ng/mL), or SB431542 (1 μM) for a period of 24 hours; following which whole-cell lysates were extracted for subsequent protein or mRNA studies. Extracted protein was first quantitated using the BCA assay and then glucocorticoid receptor isoforms (GRα-A, GRβ, GRγ, GRP, GRA, GRα-C, and GRα-D) and serotonin transporter proteins were semi-quantitated through Western blot analysis. The A549 cell line was used as the internal standard as well as the positive control for both proteins; and cofilin was used as a loading control for all wells. Extracted mRNA was quantitated using NanoString nCounter techniques where total glucocorticoid receptor mRNA were measured. All data were presented as mean ± standard deviation. Cell viability assay and Western blot data were analysed via one-way ANOVA with Tukey’s post-hoc comparison of means; while NanoString nCounter data were analysed via unpaired student T-test with Welch’s correction. These statistical analyses were performed using GraphPad Prism Version 8.0, with a cut-off p < 0.05 for statistical significance.
Results
MTT and LDH viability assays showed that hydrocortisone and TGF-β1 treatments did not affect overall cell viability in either SWAN-71 or JEG-3 cells after 24 hours (p > 0.05). Western blot analysis revealed that both hydrocortisone and TGF-β1, in isolation and in combination, downregulated GRα-A isotype protein expression in both SWAN-71 and JEG-3 cells after 24 hours with no additive effects observed when combined (p < 0.05). Further, TGF-β1 also upregulated GRβ protein expression in JEG-3 cells (p < 0.05). In SWAN-71 and JEG-3 cells treated with hydrocortisone or TGF-β1, individually and in combination, there was significant upregulation of SERT protein expression after 24 hours with no additive effects observed when combined (p < 0.05). Moreover, hydrocortisone and TGF-β1 had no effect on SWAN-71 cell total GR mRNA expression after 24 hours through NanoString nCounter analysis. Mifepristone and SB431542 had no effect on GR isotype nor SERT protein expression after 24-hour treatments in both SWAN-71 and JEG-3 cell lines (p > 0.05). SB431542 also had no effect on total GR mRNA expression after 24-hour treatments in SWAN-71 cells (p > 0.05).
Conclusion
The present study was the first to investigate the effects of stress and inflammatory mediators on cell viability, GR isotype and SERT protein expression, as well as total GR mRNA expression in the placental cell lines, SWAN-71 and JEG-3. Novel findings included the downregulation of GRα-A and upregulation of SERT protein expression after treatment with hydrocortisone or TGF-β1, individually and in combination, with no additive effects in the placental cell lines, SWAN-71 and JEG-3. TGF-β1 was also observed to upregulate GRβ in JEG-3 cells. These results indicate that perturbations in stress and inflammatory physiology can have deleterious effects on both GR and serotonin signalling processes that can alter trophoblast function and play a role in the aetiologies of pregnancy-related pathologies such as PE, IUGR, and PTB.<br>Thesis (Masters)<br>Master of Medical Research (MMedRes)<br>School of Medical Science<br>Griffith Health<br>Full Text
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Storbeck, Karl-Heinz. "The influence of dual CYP17 expression on adrenal steroidogenesis in the South African Angora Goat." Thesis, Link to the online version, 2008. http://hdl.handle.net/10019.1/1101.
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Costa, Nathalia dos Santos [UNESP]. "Obstrução experimental de jejuno em eqüinos: efeito da hidrocortisona nos parâmetros clínicos e laboratoriais." Universidade Estadual Paulista (UNESP), 2008. http://hdl.handle.net/11449/101132.
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Made available in DSpace on 2014-06-11T19:31:08Z (GMT). No. of bitstreams: 0
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costa_ns_dr_jabo.pdf: 657826 bytes, checksum: ea3cd1fea9c1ec9dc87c6c0888f96d4d (MD5)<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)<br>Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)<br>A síndrome abdômen agudo é uma das principais doenças dos eqüinos, colocando em risco a vida do paciente quando não se institui rapidamente um tratamento adequado. Com o incremento de informações sobre lesões isquêmicas difundiu-se o conceito de que a reperfusão nestes tecidos, apesar de essencial para prevenir a morte celular por anoxia, induz efeito paradoxal de agravamento das lesões pré-existentes, o que se denomina lesão de reperfusão. Os glicocorticóides representam uma alternativa terapêutica para o tratamento das lesões de reperfusão. No estudo proposto foram utilizados 15 eqüinos adultos, machos e fêmeas, sem alterações clínicas aparentes, distribuídos aleatoriamente em três grupos de cinco animais, sob neuroleptoanalgesia e anestesia local, submetidos ou não à obstrução experimental do jejuno, mediante a colocação de um balão intraluminal, , para reproduzir a isquemia intestinal o quadro de abdômen agudo. Os eqüinos do grupo I foram submetidos a todas as manobras cirúrgicas aplicadas aos dos outros grupos, exceto a distensão do balão para provocar obstrução; os do grupo II foram submetidos à isquemia do jejuno durante 4 horas; e os grupo III foram submetidos à isquemia de 4 horas, seguida de tratamento com hidrocortisona uma hora antes da desobstrução. Para os exames laboratoriais, foram obtidas amostras de material biológico em quatro momentos: uma hora antes do procedimento cirúrgico e aplicação da neuroleptoanalgesia (M1), ao final da isquemia (M2) e uma hora (M3) e 18 horas (M4) após o início da reperfusão. Para a verificação de lesões à distância, as amostras de diversos órgãos foram colhidas na ocasião da necropsia ao término do experimento.<br>The acute abdomen syndrome is a common equine’s disease, which goes on risk the patient when a correct treatment is not established. The reperfusion in ischemical tissues, despite it is essential in preventing cell death by anoxia, leads a paradoxical effect in worsing the pre-existed lesions, was spread and its called reperfusion lesion. Glucocorticoids represents an alternative to treatment of reperfusion’s lesions. In the proposed study, were used 15 adults horses, male or female, without clinical apparent changes, distributed ramdonly in three groups of five animals. These animals were submitted or not to jejuni experimental obstruction through intraluminal ballon, under tranquilization and local anesthesia to imitate acute abdomen. The group I was submitted to surgical procedures, except the distention of the balloon to induce obstruction; the group II was submitted to jejuni’s ischemia for 4 hours and the group III was submitted to jejuni’s ischemia for 4 hours followed by hydrocortisone treatment one hour before desobstruction. For laboratorial tests, samples of biological material were obtained in four moments: one hour before surgical procedure and practice of drugs (M1), in the end of ischemia (M2) and one hour (M3) and 18 hours (M4) after the beginning of reperfusion. To verify distant lesions, samples of many organs were collected in the necropsy at the end of experiment.
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Byrd-Craven, Jennifer. "The relationship between cortisol and social stress in late adolescent girls' friendships." Diss., Columbia, Mo. : University of Missouri-Columbia, 2007. http://hdl.handle.net/10355/4849.
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Thesis (Ph. D.)--University of Missouri-Columbia, 2007.<br>The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. Title from title screen of research.pdf file (viewed on November 26, 2007) Vita. Includes bibliographical references.
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Wall, Sarah Josephine. "Effects of physical activity on cortisol levels in African American toddlers attending full-time daycare." Auburn, Ala., 2005. http://repo.lib.auburn.edu/2005%20Fall/Dissertation/WALL_SARAH_59.pdf.
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Valiquette, Luc François. "Association between self-reported childhood maltreatment and cortisol profiles in psychotic patients." Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=112314.
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Childhood maltreatment is extremely common in patients diagnosed with psychotic disorders. Moreover, it has been linked with impaired functioning of the Hypothalamic-Pituitary-Adrenal axis. Furthermore, abnormality of the HPA has been found in psychotic patients. Presence of childhood maltreatment could then explain why the HPA axis is dysfunctional in these subjects. Our objective was to clarify the role of childhood trauma in the cortisol profiles of psychotic patients. Thirty-one patients underwent assessments of childhood maltreatment. Diurnal cortisol and cortisol after a controlled psychosocial stress were also collected. Our results show that childhood trauma is associated with lower cortisol levels during the morning and during 24 hours. In men diagnosed with psychosis, childhood trauma is also associated with a higher cortisol response during psychosocial stress. This suggests an alteration of the HPA axis in psychotic patients, resulting from early trauma. Moreover, our results suggest that looking at specific types of childhood abuse may also be important.
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Marin, Marie-France. "Immediate and delayed effects of stress on a reactivitated declarative long-term memory trace." Thesis, McGill University, 2009. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=116034.
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In 1968, a study demonstrated that consolidated memories can be affected again if they are reactivated. Given the importance of the stress hormones glucocorticoids (GCs) on memory consolidation, the goal of the current study was to assess whether GCs had the capacity to affect a reactivated long-term memory and whether neutral and emotional memories were affected differently. At the first session, participants encoded a movie containing neutral and emotional scenes. Two days later, they recalled the story. Half of them were then exposed to a psychosocial stressor. Memory performance was assessed again right after the stressor and five days later. The stressed group recalled less neutral material five days after the stressor compared to controls. Immediately after the stressor, the stressed group recalled more emotional material than controls. Moreover, this enhanced memory trace was maintained across time. This highlights the importance of minimizing exposure to stressful contexts when reactivating emotional memories.
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Neyrão, Iuri Moraes. "Mediação de respostas imunes e do sistema de defesa antioxidante pelo cortisol em pacu (Piaractus mesopotamicus) /." Jaboticabal, 2017. http://hdl.handle.net/11449/150261.
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Orientador: Elisabeth Criscuolo Urbinati<br>Coorientadora: Jaqueline Dalbello Biller Takahashi<br>Banca: Luis Henrique Montrezor<br>Banca: Marisa Narciso Fernandes<br>Resumo: O objetivo deste trabalho foi avaliar se o sistema imune inato e o sistema antioxidante hepático são mediados pelo cortisol circulante, em condições de elevação exógena e endógena do hormônio em pacu. Os peixes foram submetidos aos tratamentos: alimentados com ração comercial RC controle (C); alimentados com RC contendo 400 mg de hidrocortisona / kg (HC); expostos a captura por 2 minutos seguida de exposição aérea por 4 minutos (E). No dia da amostragem, os grupos C e HC foram alimentados com a respectiva ração e amostrados 1, 3, 6, 24 e 72 horas depois (n=9), enquanto o grupo E foi alimentado com RC, no mesmo horário dos outros grupos, em seguida exposto ao estressor e amostrado 1, 3, 6, 24 e 72 horas depois. Os peixes tiveram sangue, fígado e baço coletados. No sangue foram determinadas: a concentração de cortisol, glicose, atividade respiratória de leucócitos ARL, concentração sérica de lisozima (CSL) e atividade hemolítica do sistema complemento (AHC). O fígado foi utilizado para determinação da atividade das enzimas catalase (CAT) e glutationa peroxidase (GPx). O baço foi utilizado para cálculo do índice esplenossomático e análise histológica para observação de polpa branca, polpa vermelha, melanomacrófagos e centros de melanomacrófagos. Os resultados obtidos demonstraram que o estresse exógeno e endógeno, de modo geral, elevaram as concentrações sanguíneas de cortisol e glicose. Inicialmente (3 horas), o estresse de manejo aumentou a ARL, mas de modo geral a elevação do... (Resumo completo, clicar acesso eletrônico abaixo)<br>Abstract: The aim of this study was to evaluate if the innate immune system and the hepatic antioxidant system are mediated by circulating cortisol, under conditions of exogenous and endogenous elevation of the hormone in pacu. The fish were submitted to the treatments: fed with commercial RC fed control (C); fed with RC containing 400 mg hydrocortisone / kg feed (HC); exposed to capture for 2 minutes followed by air exposure for 4 minutes (E). On the sampling day, the groups C and HC were fed with the respective feed and sampled 1, 3, 6, 24 and 72 hours later (n= 9), while group E was fed as the other groups, then exposed to the stressor and sampled 1, 3, 6, 24 and 72 hours later. The fish had blood, liver and spleen collected. In the blood it were determined: the concentration of cortisol, glucose, respiratory activity of leukocytes ARL, serum concentration of lysozyme (CLS) and complement haemolytic activity (ACH). The liver was used to determine the activity of the enzymes catalase (CAT) and glutathione peroxidase (GPx). The spleen was used to calculate the splenosomatic index and histological analysis for observation of white pulp, red pulp, melanomacrophages and melanomacrophage centers. The results obtained demonstrated that exogenous and endogenous stress, in general, increased blood concentrations of cortisol and glucose. Initially (3 hours), the stressful handling increased ARL, but in general the elevation of cortisol was associated with a reduction of ARL and AHC, as well as the activity of the GPx and CAT enzymes. The stressful handling additionally caused the appearance of melanomacrophages and melanomacrophage centers in the spleen, suggesting cellular damage in this lymphoid organ.<br>Mestre
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Bomfim, Gabriela Facholi. "Produção de leite em cabras Sannen : relações estresse, IGF-1 e apoptose /." Jaboticabal, 2016. http://hdl.handle.net/11449/147110.
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Orientador: João Alberto Negrão<br>Banca: Luis Felipe Prada e Silva<br>Banca: Lenira El Faro Zadra<br>Banca: Kênia Cardoso Bícego<br>Banca; Márcia Helena Machado da Rocha Fernandes<br>Resumo: O aumento da produção leiteira no início de lactação depende do número e capacidade de síntese das células epiteliais mamárias. Porém, alguns estudos indicam que a partir do pico da lactação, o processo de apoptose das células mamárias aumentam gradualmente até o final da lactação, reduzindo progressivamente o número de células epiteliais bem como sua capacidade de síntese de leite. Alguns estudos sugerem que as alterações metabólicas causadas pelo estresse durante a lactação, podem via ação do cortisol, intensificar o processo de apoptose na glândula mamária.Inicialmente presumimos que o cortisol reduz a liberação de IGF-1 (que tem sido visto como hormônio anti-apoptótico, prolongando assim a lactação) e acelera o processo apoptose das células epiteliais. Neste contexto, o estudo da liberação do cortisol e sua relação com o IGF-1 são ferramentas importantes para avaliar o efeito do estresse na apoptose das células mamárias durante a lactação. Ao estudar via respostas zootécnicas e fisiológicas a associação entre o cortisol e IGF-1 será possível entender as relações entre a apoptose e proliferação celular durante a lactação. Utilizando como modelo experimental cabras Saanen em lactação, esse projeto propõe estudar se o aumento de cortisol reduz a liberação de IGF-1 acelerando a apoptose das células epiteliais bem como, se o IGF-1 realmente possui efeito anti-apoptótico nas células epiteliais.Os estudos foram realizadosin vivo(Experimento I) e in vitro (Experimento II). Para t... (Resumo completo, clicar acesso eletrônico abaixo)<br>Abstract: The increase in milk production in early lactation depends on the number and capacity of synthesis of mammary epithelial cells. However, some studies indicate that from the peak of lactation the process of apoptosis of mammalian cells gradually increases until the end of the same progressively reducing the number of epithelial cells as well as their milk synthesis capability. Some studies suggest that the metabolic alterations caused by stress during lactation can via cortisol action to intensify the process of apoptosis in mammary gland. At first, we assume that cortisol reduces the release of IGF-1 (which has beenseen as antiapoptotic hormone, thus prolonging lactation) and accelerates the apoptosis of epithelial cells. In this context, the study of the release of cortisol and its relationship with the IGF-1 are important tools to evaluate the effect of stress on apoptosis of mammalian cells during lactation. By studying via zootechnical and physiological responses to the association between cortisol and IGF-1, it will be possible to understand the relationship between apoptosis and cell proliferation during lactation. Using an experimental Saanen goats lactating model, this project proposes to study the increase of cortisol reduces the release of IGF-1 accelerating the apoptosis of epithelial cells as well as IGF-1 actually has anti-apoptotic effect on epithelial cells, studies will be conducted in vivo (Experiment I) and in vitro (Experiment II). Therefore, the experimental goats will bechalleng via exogenous administration of ACTH (standard physiological stress)<br>Doutor