Relevant bibliographies by topics / Hydrogel

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'Hydrogel'

Author: Grafiati
Published: 4 June 2021
Last updated: 29 March 2025

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Journal articles on the topic "Hydrogel"

1

Li, Zhangkang, Cheng Yu, Hitendra Kumar, Xiao He, Qingye Lu, Huiyu Bai, Keekyoung Kim, and Jinguang Hu. "The Effect of Crosslinking Degree of Hydrogels on Hydrogel Adhesion." Gels 8, no. 10 (October 21, 2022): 682. http://dx.doi.org/10.3390/gels8100682.

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The development of adhesive hydrogel materials has brought numerous advances to biomedical engineering. Hydrogel adhesion has drawn much attention in research and applications. In this paper, the study of hydrogel adhesion is no longer limited to the surface of hydrogels. Here, the effect of the internal crosslinking degree of hydrogels prepared by different methods on hydrogel adhesion was explored to find the generality. The results show that with the increase in crosslinking degree, the hydrogel adhesion decreased significantly due to the limitation of segment mobility. Moreover, two simple strategies to improve hydrogel adhesion generated by hydrogen bonding were proposed. One was to keep the functional groups used for hydrogel adhesion and the other was to enhance the flexibility of polymer chains that make up hydrogels. We hope this study can provide another approach for improving the hydrogel adhesion generated by hydrogen bonding.
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Lee, Celine, He-Shin Huang, Yun-Ying Wang, You-Sheng Zhang, Rajan Deepan Chakravarthy, Mei-Yu Yeh, Hsin-Chieh Lin, and Jeng Wei. "Stretchable, Adhesive, and Biocompatible Hydrogel Based on Iron–Dopamine Complexes." Polymers 15, no. 22 (November 10, 2023): 4378. http://dx.doi.org/10.3390/polym15224378.

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Hydrogels’ exceptional mechanical strength and skin-adhesion characteristics offer significant advantages for various applications, particularly in the fields of tissue adhesion and wearable sensors. Herein, we incorporated a combination of metal-coordination and hydrogen-bonding forces in the design of stretchable and adhesive hydrogels. We synthesized four hydrogels, namely PAID-0, PAID-1, PAID-2, and PAID-3, consisting of acrylamide (AAM), N,N′-methylene-bis-acrylamide (MBA), and methacrylic-modified dopamine (DA). The impact of different ratios of iron (III) ions to DA on each hydrogel’s performance was investigated. Our results demonstrate that the incorporation of iron–dopamine complexes significantly enhances the mechanical strength of the hydrogel. Interestingly, as the DA content increased, we observed a continuous and substantial improvement in both the stretchability and skin adhesiveness of the hydrogel. Among the hydrogels tested, PAID-3, which exhibited optimal mechanical properties, was selected for adhesion testing on various materials. Impressively, PAID-3 demonstrated excellent adhesion to diverse materials and, combined with the low cytotoxicity of PAID hydrogel, holds great promise as an innovative option for biomedical engineering applications.
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Wang, Xinyu, Huiyuan Wang, Hongmin Zhang, Tianxi Yang, Bin Zhao, and Juan Yan. "Investigation of the Impact of Hydrogen Bonding Degree in Long Single-Stranded DNA (ssDNA) Generated with Dual Rolling Circle Amplification (RCA) on the Preparation and Performance of DNA Hydrogels." Biosensors 13, no. 7 (July 23, 2023): 755. http://dx.doi.org/10.3390/bios13070755.

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DNA hydrogels have gained significant attention in recent years as one of the most promising functional polymer materials. To broaden their applications, it is critical to develop efficient methods for the preparation of bulk-scale DNA hydrogels with adjustable mechanical properties. Herein, we introduce a straightforward and efficient molecular design approach to producing physically pure DNA hydrogel and controlling its mechanical properties by adjusting the degree of hydrogen bonding in ultralong single-stranded DNA (ssDNA) precursors, which were generated using a dual rolling circle amplification (RCA)-based strategy. The effect of hydrogen bonding degree on the performance of DNA hydrogels was thoroughly investigated by analyzing the preparation process, morphology, rheology, microstructure, and entrapment efficiency of the hydrogels for Au nanoparticles (AuNPs)–BSA. Our results demonstrate that DNA hydrogels can be formed at 25 °C with simple vortex mixing in less than 10 s. The experimental results also indicate that a higher degree of hydrogen bonding in the precursor DNA resulted in stronger internal interaction forces, a more complex internal network of the hydrogel, a denser hydrogel, improved mechanical properties, and enhanced entrapment efficiency. This study intuitively demonstrates the effect of hydrogen bonding on the preparation and properties of DNA hydrogels. The method and results presented in this study are of great significance for improving the synthesis efficiency and economy of DNA hydrogels, enhancing and adjusting the overall quality and performance of the hydrogel, and expanding the application field of DNA hydrogels.
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Palungan, Juliana, Widya Luthfiyah, Apon Zaenal Mustopa, Maritsa Nurfatwa, Latifah Rahman, Risfah Yulianty, Nasrul Wathoni, Jin-Wook Yoo, and Nurhasni Hasan. "The Formulation and Characterization of Wound Dressing Releasing S-Nitrosoglutathione from Polyvinyl Alcohol/Borax Reinforced Carboxymethyl Chitosan Self-Healing Hydrogel." Pharmaceutics 16, no. 3 (February 29, 2024): 344. http://dx.doi.org/10.3390/pharmaceutics16030344.

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Self-healing hydrogels often lack mechanical properties, limiting their wound-dressing applications. This study introduced S-Nitrosoglutathione (GSNO) to self-healing hydrogel-based wound dressings. Self-healing hydrogel mechanical properties were improved via polymer blends. Applying this hydrogel to the wound site allows it to self-heal and reattach after mechanical damage. This work evaluated polyvinyl alcohol (PVA)-based self-healing hydrogels with borax as a crosslinking agent and carboxymethyl chitosan as a mechanical property enhancer. Three formulations (F1, F4, and F7) developed self-healing hydrogels. These formulations had borax concentrations of 0.8%, 1.2%, and 1.6%. An FTIR study shows that borate ester crosslinking and hydrogen bonding between polymers generate a self-healing hydrogel. F4 has a highly uniform and regular pore structure, as shown by the scanning electron microscope image. F1 exhibited faster self-healing, taking 13.95 ± 1.45 min compared to other formulations. All preparations had pH values close to neutrality, making them suitable wound dressings. Formula F7 has a high drug content (97.34 ± 1.21%). Good mechanical qualities included high tensile stress–strain intensity and Young’s modulus. After 28 h of storage at −20 °C, 5 °C, and 25 °C, the self-healing hydrogel’s drug content dropped significantly. The Korsmeyer–Peppas release model showed that the release profile of GSNO followed Fickian diffusion. Thus, varying the concentration of crosslinking agent and adding a polymer affects self-healing hydrogels’ physicochemical properties.
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Dai, Bailin, Ting Cui, Yue Xu, Shaoji Wu, Youwei Li, Wu Wang, Sihua Liu, Jianxin Tang, and Li Tang. "Smart Antifreeze Hydrogels with Abundant Hydrogen Bonding for Conductive Flexible Sensors." Gels 8, no. 6 (June 13, 2022): 374. http://dx.doi.org/10.3390/gels8060374.

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Recently, flexible sensors based on conductive hydrogels have been widely used in human health monitoring, human movement detection and soft robotics due to their excellent flexibility, high water content, good biocompatibility. However, traditional conductive hydrogels tend to freeze and lose their flexibility at low temperature, which greatly limits their application in a low temperature environment. Herein, according to the mechanism that multi−hydrogen bonds can inhibit ice crystal formation by forming hydrogen bonds with water molecules, we used butanediol (BD) and N−hydroxyethyl acrylamide (HEAA) monomer with a multi−hydrogen bond structure to construct LiCl/p(HEAA−co−BD) conductive hydrogel with antifreeze property. The results indicated that the prepared LiCl/p(HEAA−co−BD) conductive hydrogel showed excellent antifreeze property with a low freeze point of −85.6 °C. Therefore, even at −40 °C, the hydrogel can still stretch up to 400% with a tensile stress of ~450 KPa. Moreover, the hydrogel exhibited repeatable adhesion property (~30 KPa), which was attributed to the existence of multiple hydrogen bonds. Furthermore, a simple flexible sensor was fabricated by using LiCl/p(HEAA−co−BD) conductive hydrogel to detect compression and stretching responses. The sensor had excellent sensitivity and could monitor human body movement.
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Jiang, Zhiqiang, Ya Li, Yirui Shen, Jian Yang, Zongyong Zhang, Yujing You, Zhongda Lv, and Lihui Yao. "Robust Hydrogel Adhesive with Dual Hydrogen Bond Networks." Molecules 26, no. 9 (May 4, 2021): 2688. http://dx.doi.org/10.3390/molecules26092688.

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Hydrogel adhesives are attractive for applications in intelligent soft materials and tissue engineering, but conventional hydrogels usually have poor adhesion. In this study, we designed a strategy to synthesize a novel adhesive with a thin hydrogel adhesive layer integrated on a tough substrate hydrogel. The adhesive layer with positive charges of ammonium groups on the polymer backbones strongly bonds to a wide range of nonporous materials’ surfaces. The substrate layer with a dual hydrogen bond system consists of (i) weak hydrogen bonds between N,N-dimethyl acrylamide (DMAA) and acrylic acid (AAc) units and (ii) strong multiple hydrogen bonds between 2-ureido-4[1H]-pyrimidinone (UPy) units. The dual hydrogen-bond network endowed the hydrogel adhesives with unique mechanical properties, e.g., toughness, highly stretchability, and insensitivity to notches. The hydrogel adhesion to four types of materials like glass, 316L stainless steel, aluminum, Al2O3 ceramic, and two biological tissues including pig skin and pig kidney was investigated. The hydrogel bonds strongly to dry solid surfaces and wet tissue, which is promising for biomedical applications.
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Juan, Chieh-Yun, You-Sheng Zhang, Jen-Kun Cheng, Yu-Hsu Chen, Hsin-Chieh Lin, and Mei-Yu Yeh. "Lysine-Triggered Polymeric Hydrogels with Self-Adhesion, Stretchability, and Supportive Properties." Polymers 16, no. 10 (May 13, 2024): 1388. http://dx.doi.org/10.3390/polym16101388.

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Hydrogels, recognized for their flexibility and diverse characteristics, are extensively used in medical fields such as wearable sensors and soft robotics. However, many hydrogel sensors derived from biomaterials lack mechanical strength and fatigue resistance, emphasizing the necessity for enhanced formulations. In this work, we utilized acrylamide and polyacrylamide as the primary polymer network, incorporated chemically modified poly(ethylene glycol) (DF-PEG) as a physical crosslinker, and introduced varying amounts of methacrylated lysine (LysMA) to prepare a series of hydrogels. This formulation was labeled as poly(acrylamide)-DF-PEG-LysMA, abbreviated as pADLx, with x denoting the weight/volume percentage of LysMA. We observed that when the hydrogel contained 2.5% w/v LysMA (pADL2.5), compared to hydrogels without LysMA (pADL0), its stress increased by 642 ± 76%, strain increased by 1790 ± 95%, and toughness increased by 2037 ± 320%. Our speculation regarding the enhanced mechanical performance of the pADL2.5 hydrogel revolves around the synergistic effects arising from the co-polymerization of LysMA with acrylamide and the formation of multiple intermolecular hydrogen bonds within the network structures. Moreover, the acid, amine, and amide groups present in the LysMA molecules have proven to be instrumental contributors to the self-adhesion capability of the hydrogel. The validation of the pADL2.5 hydrogel’s exceptional mechanical properties through rigorous tensile tests further underscores its suitability for use in strain sensors. The outstanding stretchability, adhesive strength, and fatigue resistance demonstrated by this hydrogel affirm its potential as a key component in the development of robust and reliable strain sensors that fulfill practical requirements.
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Fu, Qiang, Junxiao Tang, Weimin Wang, and Rongjie Wang. "Biocomposite Polyvinyl Alcohol/Ferritin Hydrogels with Enhanced Stretchability and Conductivity for Flexible Strain Sensors." Gels 11, no. 1 (January 11, 2025): 59. https://doi.org/10.3390/gels11010059.

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Protein-based hydrogels with stretchability and conductivity have potential applications in wearable electronic devices. However, the development of protein-based biocomposite hydrogels is still limited. In this work, we used natural ferritin to develop a PVA/ferritin biocomposite hydrogel by a repetitive freeze–thaw method. In this biocomposite hydrogel, ferritin, as a nano spring, forms a hydrogen bond with the PVA networks, which reduces the crystallinity of PVA and significantly improves the stretchability of the hydrogel. The fracture strain of the PVA/ferritin hydrogel is 203%, and the fracture stress is 112.2 kPa. The fracture toughness of the PVA/ferritin hydrogel is significantly enhanced to 147.03 kJ/m3, more than 3 times that of the PVA hydrogel (39.17 kJ/m3). In addition, the free residues and iron ions of ferritin endow the biocomposite hydrogel with enhanced ionic conductivity (0.15 S/m). The strain sensor constructed from this hydrogel shows good sensitivity (gauge factor = 1.7 at 150% strain), accurate real-time resistance response, and good long cyclic working stability when used for joint motion monitoring. The results indicate that a PVA/ferritin biocomposite hydrogel prepared by a facile method has enhanced stretchability and conductivity for flexible strain sensors. This work develops a new method for the preparation of protein-based hydrogels for wearable electronic devices.
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Xing, Wenjin, Amin Jamshidi Ghahfarokhi, Chaoming Xie, Sanaz Naghibi, Jonathan A. Campbell, and Youhong Tang. "Mechanical Properties of a Supramolecular Nanocomposite Hydrogel Containing Hydroxyl Groups Enriched Hyper-Branched Polymers." Polymers 13, no. 5 (March 6, 2021): 805. http://dx.doi.org/10.3390/polym13050805.

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Owing to highly tunable topology and functional groups, hyper-branched polymers are a potential candidate for toughening agents, for achieving supramolecular interactions with hydrogel networks. However, their toughening effects and mechanisms are not well understood. Here, by means of tensile and pure shear testings, we characterise the mechanics of a nanoparticle–hydrogel hybrid system that incorporates a hyper-branched polymer (HBP) with abundant hydroxyl end groups into the matrix of the polyacrylic acid (PAA) hydrogel. We found that the third and fourth generations of HBP are more effective than the second one in terms of strengthening and toughening effects. At a HBP content of 14 wt%, compared to that of the pure PAA hydrogel, strengths of the hybrid hydrogels with the third and fourth HBPs are 2.3 and 2.5 times; toughnesses are increased by 525% and 820%. However, for the second generation, strength is little improved, and toughness is increased by 225%. It was found that the stiffness of the hybrid hydrogel is almost unchanged relative to that of the PAA hydrogel, evidencing the weak characteristic of hydrogen bonds in this system. In addition, an outstanding self-healing feature was observed, confirming the fast reforming nature of broken hydrogen bonds. For the hybrid hydrogel, the critical size of failure zone around the crack tip, where serious viscous dissipation occurs, is related to a fractocohesive length, being about 0.62 mm, one order of magnitude less than that of other tough double-network hydrogels. This study can promote the application of hyper-branched polymers in the rapid evolving field of hydrogels for improved performance.
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Rao, Kummara Madhusudana, Kannan Badri Narayanan, Uluvangada Thammaiah Uthappa, Pil-Hoon Park, Inho Choi, and Sung Soo Han. "Tissue Adhesive, Self-Healing, Biocompatible, Hemostasis, and Antibacterial Properties of Fungal-Derived Carboxymethyl Chitosan-Polydopamine Hydrogels." Pharmaceutics 14, no. 5 (May 10, 2022): 1028. http://dx.doi.org/10.3390/pharmaceutics14051028.

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In this work, fungal mushroom-derived carboxymethyl chitosan-polydopamine hydrogels (FCMCS-PDA) with multifunctionality (tissue adhesive, hemostasis, self-healing, and antibacterial properties) were developed for wound dressing applications. The hydrogel is obtained through dynamic Schiff base cross-linking and hydrogen bonds between FCMCS-PDA and covalently cross-linked polyacrylamide (PAM) networks. The FCMCS-PDA-PAM hydrogels have a good swelling ratio, biodegradable properties, excellent mechanical properties, and a highly interconnected porous structure with PDA microfibrils. Interestingly, the PDA microfibrils were formed along with FCMCS fibers in the hydrogel networks, which has a high impact on the biological performance of hydrogels. The maximum adhesion strength of the hydrogel to porcine skin was achieved at about 29.6 ± 2.9 kPa. The hydrogel had good self-healing and recoverable properties. The PDA-containing hydrogels show good antibacterial properties on Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) bacteria. Moreover, the adhesive hydrogels depicted good viability and attachment of skin fibroblasts and keratinocyte cells. Importantly, FCMCS and PDA combined resulted in fast blood coagulation within 60 s. Hence, the adhesive hydrogel with multifunctionality has excellent potential as a wound dressing material for infected wounds.
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Dissertations / Theses on the topic "Hydrogel"

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Corkhill, P. H. "Novel hydrogel polymers." Thesis, Aston University, 1988. http://publications.aston.ac.uk/9725/.

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Hydrogels may be conveniently described as hydrophilic polymers that are swollen by, but do not dissolve in water. In this work a series of copolymer hydrogels and semi-interpenetrating polymer networks based on the monomers 2-hydroxyethyl methacrylate, N-vinyl pyrrolidone and N'N' dimethyl acrylamide, together with some less hydrophilic hydroxyalkyl acrylates and methacrylates have been synthesised. Variations in structure and composition have been correlated both with the total equilibrium water content of the resultant hydrogel and with the more detailed water binding behaviour, as revealed by differential scanning calorimetry studies. The water binding characteristics of the hydrogels were found to be primarily a function of the water structuring groups present in gel. The water binding abilities of these groups were, however, modified by steric effects. The mechanical properties of the hydrogels were also investigated. These were found to be dependent on both the polymer composition and the amount and nature of the water present in the gels. In biological systems, composite formation provides a means of producing strong, high water content materials. As an analogy with these systems hydrogel composites were prepared. In an initial study of these materials the water binding and mechanical properties of semi-interpenetrating polymer networks of N'N'dimethyl acrylamide with cellulosic type materials, with polyurethanes and with ester containing polymers were examined. A preliminary investigation of surface properties of both the copolymers and semi-interpenetrating polymer networks has been completed, using both contact angle measurements and anchorage dependent fibroblast cells. Measurable differences in surface properties attributable to structural variations in the polymers were detected by droplet techniques in the dehydrated state. However, in the hydrated state these differences were masked by the water in the gels. The use of cells enabled the underlying differences to be probed and the nature of the water structuring group was again found to be the dominant factor.
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Ma, James J. "Novel hydrogel polymers." Thesis, Aston University, 1995. http://publications.aston.ac.uk/9661/.

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Hydrogels are a unique class of polymers which swell, but do not dissolve in water. A range of 2-hydroxyethyl methacrylate based copolymer hydrogels have been synthesised and are described in this thesis. Initially, hydrogels were synthesised containing acryloylmorpholine, N,N-dimethyl acrylamide and N-vinyl pyrrolidone. Variations in structure and composition have been correlated with the sequence distribution, equilibrium water content (EWC) , mechanical and surface properties of the hydrogels. The sequence distribution was found to be dependant on the structure and reactivity of the monomers. The Ewe was found to be dependant on the water structuring groups present in the hydrogel, although the water binding abili ties were modified by steric effects. The mechanical properties were also investigated and were found to be dependant on the monomer structure, sequence distribution and the amount and nature of water in the hydrogel. The macroscopic surface properties of the hydrogels were probed using surface energy determinations and were found to be a function of the water content and the hydrogel composition. At a molecular level, surface properties were investigated using an in vitro ocular spoilation model and single protein adhesion studies. The results indicate that the sequence distribution and the polarity of the surface affect the adhesion of biological species. Finally, a range of 2-hydroxyethyl methacrylate based copolymer hydrogels containing both charged monomer groups and linear polyethers have been synthesised and described. Although variations in the Ewe are observed with the structure of the monomers, it was observed that the Ewe increased due to the polar character of the charged monomers and the chain length and hydrophilicity of the polyethers. Investigation of these hydrogel surfaces revealed subtle changes. The molecular surface properties indicate the significance of the effect of charge and molecular mobility of the groups expressed at the hydrogel surface
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Kim, Jongseong. "Stimuli-Responsive Hydrogel Microlenses." Diss., Georgia Institute of Technology, 2007. http://hdl.handle.net/1853/14496.

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This dissertation is aimed towards using stimuli-responsive pNIPAm-co-AAc microgels synthesized via free-radical precipitation polymerization to prepare stimuli-responsive hydrogel microlenses. Chapter 1 gives a detailed background of hydrogels, and their applications using responsive hydrogels. Chapter 2 describes the use of colloidal hydrogel microparticles as microlens elements and the fabrication method to form the hydrogel microlens arrays via Coulombic interactions. Chapter 3 shows the demonstration of tunable microlenses prepared by the method used in Chapter 2. In this chapter the microlenses are subjected to various pH and temperature in aqueous solutions. Chapter 4 describes that the microlens arrays constructed on Au nanoparticle-functionalized glass substrates by self-assembly display dramatic changes in lensing power in response to an impingent frequency-doubled Nd:YAG laser. The microlens photoswitching is highly reversible, with sub-millisecond lens switching times. Chapter 5 describes the development of bioresponsive hydrogel microlenses as a new protein detection technology. The microlens method is shown to be very specific for the target protein, with no detectable interference from nonspecific protein binding. Chapter 6 describes the use of bioresponsive hydrogel microlenses as a label-free biosensing scaffolding. These microstructures simultaneously act as the biosensors scaffolding/immobilization architecture, transducer, amplifier, and also allow for broad tunability of the analyte concentration to which the microlens is sensitive.
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Pareek, Pradeep. "Photo-crosslinked Surface Attached Thin Hydrogel Layers." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2005. http://nbn-resolving.de/urn:nbn:de:swb:14-1115623310082-44480.

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Stimuli sensitive polymers and hydrogels respond with large property changes to small physical and chemical stimuli (e.g. temperature, pH, ionic strength). The bulk behavior of these polymers is widely studied and they show an isotropic swelling. However, thin hydrogel layers of polymers on a substrate show a swelling behavior, which is constrained in some way. Therefore, size, confinement, patternability, response time and transition temperature of thin hydrogel layers are the most important parameters in technological applications and this study focuses on the investigation of these above-mentioned parameters. The aim of this study involves synthesis, characterization and application of thin photo-crosslinked hydrogel layers. Dimethylmaleimide (DMI) moiety was incorporated in the polymers chains and was used to introduce photo-crosslinking by [2+2] cyclodimerization reaction in the presence of UV irradiation. The following photo-crosslinkers based on DMI group were synthesized ? - Acrylate photo-crosslinker (DMIAm) - Acrylamide photo-crosslinker (DMIAAm) - Polyol photo-crosslinker (DMIPA, DMIPACl) The conventional free radical polymerization of above listed photo-crosslinker with its respective monomer resulted in formation of photo-crosslinkable polymers of (a) HEMA, (b) DMAAm, (c) NIPAAm/DMAAm, (d) NIPAAm/Cyclam. The properties of these polymers were investigated by NMR, UV-VIS spectroscopy, GPC and SPR. Thin hydrogel layers were prepared by spin coating on gold-coated LaSFN9 glass. The covalent attachment to the surface was achieved through an adhesion promoter. Swelling behavior of the thin polymer layers was thoroughly investigated by Surface Plasmon Resonance (SPR) Spectroscopy and Optical Waveguide Spectroscopy (OWS). SPR and OWS gave a wide range of information regarding the film thickness, swelling ratio, refractive index, and volume degree of swelling of the thin hydrogel layer. For hydrophilic photo-crosslinked hydrogel layers of HEMA and DMAAm, it was observed that the volume degree of swelling was independent of temperature changes but was dependent on the photo-crosslinker mol-% in the polymer. These surface attached thin hydrogel layer exhibited an anisotropic swelling. For NIPAAm photo-crosslinked hydrogel layers with DMAAm as a hydrophilic monomer, it was observed that both transition temperature (Tc) and volume degree of swelling increases with increase in the mol-% of DMAAm. To study the effect of film thickness on Tc and volume degree of swelling, hydrogels with wide range of film thickness were prepared and investigated by SPR. These results provided vital information on the swelling behavior of surface attached hydrogel layer and showed the versatility of SPR instrument for studying thin hydrogel layers. Later part of project involved synthesis of multilayer hydrogel assembly involving a thermoresponsive polymer and a hydrophilic polymer. The combination of two layers with photo-crosslinkable DMAAm polymer as base layer and photo-crosslinkable NIPAAm polymer as top layer formulate a multilayer assembly where, the base layer only swells in response to temperature and the top layer shows temperature dependent swelling. Photo-crosslinked hydrogel layers of NIPAAm, DMAAm and HEMA shows a high-resolution patterns when irradiated by UV light through a chromium mask. At last this study focused on an important application of these hydrogel layers for cell attachment processes. Cell growth, proliferation and spreading shows a biocompatible nature of these hydrogel surfaces. Such thermoresponsive photo-crosslinkable multilayer structure forms bases for future projects involving their use in actuator material and cell-attachment processes.
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Trinh, Quang Thong. "Hydrogel based piezoresistive pH sensors." Dresden TUDpress, 2006. http://deposit.d-nb.de/cgi-bin/dokserv?id=2860048&prov=M&dok_var=1&dok_ext=htm.

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Al-Shohani, Athmar Dhahir Habeeb. "Hydrogel formulations for ophthalmic delivery." Thesis, University College London (University of London), 2017. http://discovery.ucl.ac.uk/1540916/.

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Going blind is incomprehensible and with an aging population the number of people with blinding disease is increasing. Glaucoma and age related macular degeneration (AMD) are two major causes of blindness affecting people as they age. The only proven treatment for glaucoma is lowering of the intraocular pressure (IOP) which is best done by surgically placing a channel from the anterior chamber to allow aqueous outflow to drain into the subconjunctival space. The drainage channel can be formed by the use of a glaucoma drainage device (GDD) or by glaucoma filtration surgery (GFS). Both GFS and the use of a GDD often fail over time because local fibrosis (scarring) in the subconjunctival space blocks aqueous outflow resulting in the increase of IOP and disease progression. It was hypothesised that a more biocompatible GDD could be fabricated from a hydrogel, and that the hydrogel material could be used to restrict aqueous outflow to control the IOP. Hydrogels are widely used in ophthalmic applications including contact lens and intraocular lens. Since hydrogels are widely examined for use in drug delivery, it was also hypothesised that a hydrogel implant could be made for the subconjunctival space after GFS to stop tissue adhesion and to deliver locally an anti-fibrotic or anti-inflammatory drug to increase the chances for long-term surgical success. For AMD, the current treatment is intravitreal (IVT) injections of anti-VEGF antibodies approximately every 4-6 weeks. IVT injections are an invasive procedure and associated with some complications, but it is also becoming apparent that many healthcare systems around the world cannot cope with the increasing demands for IVT injections to treat AMD. To reduce the frequency for IVT injections, there is a need to develop formulations that allow a longer duration of action for therapeutic proteins in the back of the eye. Maintaining protein stability is a major challenge in formulation science and clinical use. It was further hypothesied that injectable hydrogels could also be used to formulate an antibody for IVT injection to display an extended residence time in the vitreous cavity. Free radical polymerisations of 2-hydroxyethyl methacrylate (HEMA) and 2-methacryloyloxyethyl phosphoryl choline (MPC) in the presence of a cross-linker, poly¬(ethylene glycol diacrylate) (PEGDA) were conducted to prepare HEMA-MPC co-polymer hydrogel films. Both HEMA and MPC are widely used in ophthalmic hydrogel products and MPC is known to be exceptionally biocompatible, although it must only be used as a co-polymer to ensure there are suitable processing and mechanical properties in the resulting hydrogel. Different HEMA-MPC hydrogels with increasing relative stoichiometries of MPC (0%-100% (w/w)) were prepared and characterised to determine if water flow through the gel was possible. Unfortunately the hydrogel films formed have low permeability (1.1×10-18 m2 s-1 pas-1) compared to the permeability required to control flow at a rate of 2 μL/min under 10-15 mmHg IOP, which is (6 ×10-14 m2 s-1 pas-1). Although the HEMA-MPC hydrogel films could not be used for flow control, they were further examined for use as potential implants for local tissue site drug delivery in subconjunctiva. HEMA-MPC hydrogels with 10% MPC were found to offer the best balance between water content, mechanical strength and drug loading and release that was required for the possible implantation drug loaded films derived from a range drugs (dexamethasone, pirfenidone and doxycycline). The process used for drug loading of dexamethasone was optimised by using, methanol and the in vitro half-life of DEX was increased from 1.8 to 9.1 days with release being sustained for more than 3 weeks. There are other causes of subconjunctival scarring, in particular trachoma, which is the main cause of blindness due to infection. Doxycycline is thought to be a good candidate drug for treating patients after trachoma surgery because it has both anti-bacterial and anti-fibrotic properties. As a water-soluble drug, doxycycline release could not be sustained for more than 3 days, so the 10% MPC films were modified with the incorporation of β-cyclodextrin (β-CD) in an effort exploit the possible affinity of doxycycline with β-CD to prolong doxycycline release. Several methods were examined to introduce β-CD into the HEMA-MPC films including the formation of HEMA-MPC films with pendant β-CD, the embedding of β-CD cross-linked particles within the hydrogel network and formation of an interpenetrating network (IPN) of β-CD and HEMA-MPC. Unfortunately, the release profile of doxycycline was similar in the modified and non-modified HEMA-MPC hydrogels. To evaluate hydrogels for use in IVT injections of antibodies, N-isopropylacylamide (NIPAAm) thermoresponsive hydrogels were evaluated. Three different macromolecular hydrophilic cross-linkers were evaluated; PEGDA, phosphorylcholine 3059 (PC 3059) and acrylated hyaluronic acid (Ac-HA). The prepared hydrogels were characterised regarding physical properties such as water content, water retention thermoresponsivness and protein release. The thermal responsiveness decreased with increasing cross-linker percentage. Modification in the type and percentage of cross-linker used allowed the preliminary screening of the different formulations. Hydrogel formulations made with 40 mg NIPAAm as monomer and 8 μL PEGDA, 20 mg PC3059 or 4 mg Ac-HA were able to sustain the release of antibodies for a month in a validated in vitro model of the eye.
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Read, Helen E. S. B. Massachusetts Institute of Technology. "Rheometric measurement of hydrogel toughness." Thesis, Massachusetts Institute of Technology, 2020. https://hdl.handle.net/1721.1/127870.

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Thesis: S.B., Massachusetts Institute of Technology, Department of Mechanical Engineering, May, 2020
Cataloged from the official PDF of thesis.
Includes bibliographical references (pages 11-12).
As soft physical gels become more popular due to their biological applications, there is increased interest in measuring mechanical properties such as toughness. However, traditional tensile testing methods do not work for such materials due to the intrinsic softness of the material. We present a novel method for measuring fracture energy using a rheometer and show it is broadly consistent with the pure shear test, a standard method where the material exhibits mode I fracture. This method has potential applications in characterizing a wide range of soft and transient gels.
by Helen E. Read.
S.B.
S.B. Massachusetts Institute of Technology, Department of Mechanical Engineering
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Hamilton, C. J. "Transport phenomena in hydrogel membranes." Thesis, Aston University, 1988. http://publications.aston.ac.uk/9719/.

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In this thesis the factors surrounding the permeation of alkali and alkaline earth metal salts through hydrogel membranes are investigated. Although of relevance to aqueous separations in general, it was with their potential application in sensors that this work was particularly concerned. In order to study the effect that the nature of the solute has on the transport process, a single polymer matrix, poly (2-hydroxyethyl methacrylate), was initially studied. The influence of cation variation in the presence of a fixed anion was looked at, followed by the effect of the anion in the presence of a fixed cation. The anion was found to possess the dominant influence and tended to subsume any influence by the cation. This is explained in terms of the structure-making and structure-breaking characteristics of the ions in their solute-water interactions. Analogies in the transport behaviour of the salts are made with the Hofmeister series. The effect of the chemical composition of the polymer backbone on the water structuring in the hydrogel and, consequently, transport through the membrane, was investigated by preparing a series of poly (2-hydroxyethyl methacrylate) copolymer membranes and determining the permeability coefficient of salts with a fixed anion. The results were discussed in terms of the `free-volume' model of permeation and the water structuring of the polymer backbone. The ability of ionophores to selectively modulate the permeation of salts through hydrogel membranes was also examined. The results indicated that a dualsorption model was in operation. Finally, hydrogels were used as membrane overlays on coated wire ion-selective electrodes that employed conventional plasticised-PVC-valinomycin based sensing membranes. The hydrogel overlays were found to affect the access of the analyte but not the underlying electrochemistry.
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Huettner, Nick. "Developing hydrogel systems for Biofabrication." Thesis, Queensland University of Technology, 2019. https://eprints.qut.edu.au/126397/1/Nick_Huettner_Thesis.pdf.

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The two research projects cover the versatile applications of hydrogels in biofabrication. Hydrogels find application as synthetic matrices in bioprinting, can be easily modified with bioactive motifs and processed by robotic systems, enabling high-throughput screening (HTS) approaches. The first project targeted cellular response to cell adhesion peptides in poly(ethylene glycol)-based hydrogels. An upscalable platform using a robotic system was developed, enabling HTS of the peptide-modified hydrogel matrices, tailorable to different cell types. The second project aimed to develop a tailorable physical hydrogel for bioprinting, based on different architectures of a poly(2-oxazoline)-b-poly(2-oxazine) copolymer. Hydrogel properties were evaluated by rheology.
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Gholap, S. G. "Hydrogel membranes for bio-separations." Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 2005. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/2436.

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Books on the topic "Hydrogel"

1

Li, Hua. Smart Hydrogel Modelling. Berlin, Heidelberg: Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-642-02368-2.

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Corkhill, Philip Harold. Novel hydrogel polymers. Birmingham: Aston University. Department of Chemical Engineering and AppliedChemistry, 1988.

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Li, Hua. Smart hydrogel modelling. Heidelberg: New York, 2009.

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Chu, Liang-Yin, Rui Xie, Xiao-Jie Ju, and Wei Wang. Smart Hydrogel Functional Materials. Berlin, Heidelberg: Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-642-39538-3.

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Gerlach, Gerald, and Karl-Friedrich Arndt, eds. Hydrogel Sensors and Actuators. Berlin, Heidelberg: Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-540-75645-3.

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Lyon, L. Andrew, and Michael Joseph Serpe, eds. Hydrogel Micro and Nanoparticles. Weinheim, Germany: Wiley-VCH Verlag GmbH & Co. KGaA, 2012. http://dx.doi.org/10.1002/9783527646425.

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Gerlach, Gerald, and Karl-Friedrich Arndt. Hydrogel sensors and actuators. Heidelberg: Springer, 2009.

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Choi, Andy H., and Besim Ben-Nissan. Hydrogel for Biomedical Applications. Singapore: Springer Nature Singapore, 2024. http://dx.doi.org/10.1007/978-981-97-1730-9.

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Hamilton, Colin James. Transport phenomena in hydrogel membranes. Birmingham: Aston University. Department of Chemical Engineering and Applied Chemistry, 1988.

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Trevett, Adrian Simon. The mechanical properties of hydrogel polymers. Birmingham: Aston University. Department of Chemical Engineering and Applied Chemistry, 1991.

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Book chapters on the topic "Hydrogel"

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Nicoletta, Fiore Pasquale, Giovanni De Filpo, and Patrizia Formoso. "Hydrogel." In Encyclopedia of Membranes, 977–80. Berlin, Heidelberg: Springer Berlin Heidelberg, 2016. http://dx.doi.org/10.1007/978-3-662-44324-8_2015.

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Nicoletta, Fiore Pasquale, Giovanni De Filpo, and Patrizia Formoso. "Hydrogel." In Encyclopedia of Membranes, 1–4. Berlin, Heidelberg: Springer Berlin Heidelberg, 2015. http://dx.doi.org/10.1007/978-3-642-40872-4_2015-1.

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Gooch, Jan W. "Hydrogel." In Encyclopedic Dictionary of Polymers, 374. New York, NY: Springer New York, 2011. http://dx.doi.org/10.1007/978-1-4419-6247-8_6108.

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Kim, Moon Suk, and Kinam Park. "Injectable Hydrogel." In Encyclopedia of Nanotechnology, 1–7. Dordrecht: Springer Netherlands, 2015. http://dx.doi.org/10.1007/978-94-007-6178-0_100-2.

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Kim, Moon Suk, and Kinam Park. "Injectable Hydrogel." In Encyclopedia of Nanotechnology, 1600–1606. Dordrecht: Springer Netherlands, 2016. http://dx.doi.org/10.1007/978-94-017-9780-1_100.

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Holowka, Eric P., and Sujata K. Bhatia. "Hydrogel Materials." In Drug Delivery, 225–64. New York, NY: Springer New York, 2014. http://dx.doi.org/10.1007/978-1-4939-1998-7_6.

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Nicoletta, Fiore Pasquale, Giovanni De Filpo, and Patrizia Formoso. "Hydrogel Membranes." In Encyclopedia of Membranes, 982–85. Berlin, Heidelberg: Springer Berlin Heidelberg, 2016. http://dx.doi.org/10.1007/978-3-662-44324-8_1912.

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Nicoletta, Fiore Pasquale, Giovanni De Filpo, and Patrizia Formoso. "Hydrogel Nanoparticles." In Encyclopedia of Membranes, 985–87. Berlin, Heidelberg: Springer Berlin Heidelberg, 2016. http://dx.doi.org/10.1007/978-3-662-44324-8_1913.

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Piacentini, Emma. "Hydrogel Capsules." In Encyclopedia of Membranes, 980–82. Berlin, Heidelberg: Springer Berlin Heidelberg, 2016. http://dx.doi.org/10.1007/978-3-662-44324-8_1946.

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Deyhle, Hans, Georg Schulz, Bert Müller, Roger H. French, Roger H. French, Meghan E. Samberg, Nancy A. Monteiro-Riviere, et al. "Injectable Hydrogel." In Encyclopedia of Nanotechnology, 1091–96. Dordrecht: Springer Netherlands, 2012. http://dx.doi.org/10.1007/978-90-481-9751-4_100.

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Conference papers on the topic "Hydrogel"

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Wallmersperger, Thomas, and Gabriele Sadowski. "Hydrogel research in Germany: the priority programme, Intelligent Hydrogels." In SPIE Smart Structures and Materials + Nondestructive Evaluation and Health Monitoring, edited by Yoseph Bar-Cohen and Thomas Wallmersperger. SPIE, 2009. http://dx.doi.org/10.1117/12.815430.

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Trehan, Kartik, Christopher Yu, Sasha Bakhru, and Hai-Quan Mao. "Novel Hydrogel Microfibers for Tissue Engineering." In ASME 2007 2nd Frontiers in Biomedical Devices Conference. ASMEDC, 2007. http://dx.doi.org/10.1115/biomed2007-38066.

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Cell encapsulation in hydrogels or microcapsules is one of the approaches for providing a biomimetic microenvironment to support cell survival, proliferation and functions. Microcapsules in particular have been used to improve the mass transport properties and ease of delivery through injection. More importantly, the microenvironment in hydrogels or hydrogel microcapsules can be tailored by incorporation of relevant adhesion molecules and growth factors through chemical conjugation and physical encapsulation. These functionalized hydrogels have been shown to effectively influence cell adhesion, proliferation and differentiation. In this study, we describe the preparation and characterization of a novel hydrogel fiber by polyelectrolyte complexation. This unique fiber geometry can be useful for regeneration of cylindrical tissues and for coculture of two different cell types inside and outside the fiber membrane.
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Vicente, Adam, Zachary McCreery, and Karen Chang Yan. "Printability of Hydrogels for Hydrogel Molding Based Microfluidic Device Fabrication." In ASME 2019 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2019. http://dx.doi.org/10.1115/imece2019-11545.

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Abstract Microfabrication-free methods have been developed in recent years for fabricating microfluidic devices to enable the applications of microfluidic devices to a broader range. Our group has been working on developing a process for fabricating electrospun fiber embedded microfluidic devices by integrating hydrogel molding (HGM) and electrospinning (ES), and the feasibility of this integrated method has been demonstrated through our initial study. Recently, we have modified an extrusion based 3D printer kit to deposit hydrogels and form microchannels. Agarose has been used for our previous studies owning to its temperature dependent gelation. In this study, we examined the feasibility of using gelatin gel as an alternative material for hydrogel molding. Gel materials with various concentrations were examined via printability assessments; and optimal gel materials were identified. Upon completion of pattern printing, the samples were then encapsulated in polydimethylsiloxane (PDMS) and cured; formed microchannels were then characterized via micrographic image analysis. The results show that three gels, 2% w/v agarose gel, 7.5% w/v gelatin gel, and a mixture of 2% w/v agarose gel and 7.5% w/v gelatin gel (1:1 ratio), yield consistent printed patterns and form consistent microchannels subsequently.
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Mehner, Philipp J., Sebastian Haefner, Markus Franke, Andreas Voigt, Uwe Marschner, and Andreas Richter. "Finite Element Model of a Hydrogel-Based Micro-Valve." In ASME 2016 Conference on Smart Materials, Adaptive Structures and Intelligent Systems. American Society of Mechanical Engineers, 2016. http://dx.doi.org/10.1115/smasis2016-9181.

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Micro-valves play an important role in controlling and operating microfluidic systems. Utilizing stimuli-sensitive hydrogels facilitates the construction of smart micro-valves controlled by temperature, concentration (salt, organic solvent) or pH level. We propose a finite element model which uses the thermal domain as an auxiliary domain for the volume change response of hydrogels. Behaviors like local displacements within the hydrogel are difficult to measure, but can be reproduced with finite elements. For the application of the micro-valve, the hydrogel model is connected to the fluid domain. The hydrogel is placed directly into the fluid flow and opens or closes the flow path. For this, a full iterative cycle with material properties and remeshing in each simulation step is implemented in ANSYS®. This model concept and the results will help to better understand, predict and visualize the behavior of hydrogels and support the development of highly integrated hydrogel-based microfluidic circuits.
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in het Panhuis, M. "Hydrogel electrode materials." In Devices (COMMAD). IEEE, 2010. http://dx.doi.org/10.1109/commad.2010.5699763.

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Rivera, Michael L., Jack Forman, Scott E. Hudson, and Lining Yao. "Hydrogel-Textile Composites." In CHI '20: CHI Conference on Human Factors in Computing Systems. New York, NY, USA: ACM, 2020. http://dx.doi.org/10.1145/3334480.3382788.

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Yang, Yao-Joe. "Hydrogel-based microdevices." In 2015 International Symposium on VLSI Design, Automation and Test (VLSI-DAT). IEEE, 2015. http://dx.doi.org/10.1109/vlsi-dat.2015.7114543.

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McCallum, Don, Cameron Ferris, Paul Calvert, Gordon Wallace, and Marc in het Panhuis. "Printed hydrogel materials." In 2010 International Conference on Nanoscience and Nanotechnology (ICONN). IEEE, 2010. http://dx.doi.org/10.1109/iconn.2010.6045215.

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Voigt, Andreas, Uwe Marschner, and Andreas Richter. "Multiphysics Equivalent Circuit of a Thermally Controlled Hydrogel-Micro Valve." In ASME 2015 Conference on Smart Materials, Adaptive Structures and Intelligent Systems. American Society of Mechanical Engineers, 2015. http://dx.doi.org/10.1115/smasis2015-8996.

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Hydrogels consist of a network of cross-linked polymers that swell when put into water. For temperature-sensitive smart hydrogels the equilibrium hydrogel size depends on the temperature of the liquid. These hydrogels are used to build temperature-controlled fluidic valves. Here we present an equivalent circuit model of such a hydrogel valve. The transient behavior is based on the model by Tanaka with three additional assumptions: 1. Only the fundamental mode of the deformation field, i.e. the slowest-decaying exponential temporal behavior, is relevant. 2. There are distinct equilibrium sizes for the swollen and the de-swollen state. 3. As observed in experiment, the swollen gel and the de-swollen gel have different elastic moduli, which affect the time constants of swelling vs. de-swelling. The resulting network model includes three physical subsystems: the thermal subsystem, the polymeric subsystem and the fluidic subsystem. The thermal subsystem considers the temperature of the heater, of the adhesive and of the hydrogel. It is assumed that adhesive, housing and hydrogel act as heat capacities in combination with heat resistors. The modeled polymeric subsystem causes in addition time delays for swelling and de-swelling of first order with different delay constants. The fluidic subsystem basically includes the fluidic channel between hydrogel and housing with time varying cross section, which is modeled as controlled source. All subsystems are described and coupled within one single circuit. Thus the transient behavior of the hydrogel can be calculated using a circuit simulator. Simulation results for an assumed hydrogel setup are presented.
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Erikson, Isaac E., Cindy Chung, Jason A. Burdick, and Robert L. Mauck. "Hyaluronic Acid Macromer Concentration Influences Functional MSC Chondrogenesis in Photocrosslinked MSC-Laden Hydrogels." In ASME 2008 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2008. http://dx.doi.org/10.1115/sbc2008-193096.

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Intrinsic repair of articular cartilage is poor, and so numerous tissue engineering strategies have been developed for producing functional cartilage replacements. Photopolymerizable methacrylated hyaluronic acid (MeHA) hydrogels have been developed as a potential hydrogel that possesses the distinct advantage of being biologically relevant as well as easily modified to generate a range of hydrogel properties [1]. To date, optimization of this hydrogel has been carried out by adjusting macromer molecular weight, concentration, and extent of methacrylation. Recent studies using MeHA hydrogels with auricular chondrocytes have shown that adjustments in these parameters can have significant impact on cell viability and construct maturation. [1, 2].
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Reports on the topic "Hydrogel"

1

Smith, Lisa S., Vipin K. Rastogi, Laura Burton, Pooja R. Rastogi, and Kristina Parman. A Novel Hydrogel-Based Biosampling Approach. Fort Belvoir, VA: Defense Technical Information Center, March 2016. http://dx.doi.org/10.21236/ad1006005.

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Li, Yuzhan, Vera Bocharova, Seung Pyo Jeong, Navin Kumar, Som Shrestha, Kyle Gluesenkamp, and Diana Hun. Fabrication of New PCM Hydrogel Composites. Office of Scientific and Technical Information (OSTI), April 2021. http://dx.doi.org/10.2172/1779119.

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Sirivat, Anuvat. Electrically controlled release of drugs from alginate hydrogels for transdermal drug delivery application. Chulalongkorn University, 2014. https://doi.org/10.58837/chula.res.2014.80.

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A drug-loaded conductive polymer/hydrogel blend, benzoic acid-loaded poly(3,4-ethylenedioxythiophene/alginate (BA-loaded PEDOT/Alg) hydrogel, was used as a carrier/matrix for an electrical stimuli transdermal drug delivery system (TDDS). The effects of crosslinking ratio, PEDOT particle size, and electric field strength on the release mechanism and the diffusion coefficient (D) of BA were examined by using a modified Franz-diffusion cell. The diffusion scaling exponent value of BA is close to 0.5 which refers to the diffusion controlled mechanism, or the Fickian diffusion as the BA release mechanism. The D increased when there was a decrease in the crosslinking ratio due to the mesh size-hindering effect. When increasing electric field strength, the D of BA-loaded PEDOT/Alg hydrogel increased because the cathode-BA electrorepulsion, electro-induced alginate expansion, and PEDOT electro-neutralization simultaneously occurred. The highest D belonged to a blend with the smallest PEDOT particle and highest electrical conductivity. The D of BA was a function of the matrix mesh size except when drug size/mesh size was lower than 2.38x10³, where D of BA became mesh size independent as the matrix mesh size was extremely large. Thus, the fabricated conductive polymer hydrogel blends have a great potential to be used in TDDS under electrical stimulation.
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Fernando, P. U. Ashvin Iresh, Rebecca Crouch, Bobbi Stromer, Travis Thornell, Johanna Jernberg, and Erik Alberts. Scaled-up synthesis of water-retaining alginate-based hydrogel. Engineer Research and Development Center (U.S.), December 2023. http://dx.doi.org/10.21079/11681/48032.

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Synthesis of a scaled-up version of a lithium-ion-based alginate/poly(acrylamide-co-stearyl methacrylate) [Li-alginate/P(AAm-co-SMA)] hydrogel with several optimizations for thermal signature investigations on various environmental substrates.
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จิรชาญชัย, สุวบุญ, and สิรภัทร วีระถาวร. รายงานผลการวิจัย ไฮโดรเจลแบบร่างแหสองชั้นเพื่อการพัฒนาดินอย่างยั่งยืน. วิทยาลัยปิโตรเลียมและปิโตรเคมี จุฬาลงกรณ์มหาวิทยาลัย, 2018. https://doi.org/10.58837/chula.res.2018.89.

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ไฮโดรเจล (hydrogel) เป็นวัสดุที่อยู่บนความคาดหวังในการนำมาใช้ในการแก้ปัญหาดินแห้งและการรักษาความชุ่นชื้นในดิน ในการที่จะให้ไฮโดรเจลปลดปล่อยน้ำจากโครงสร้างไฮโดรเจล ณ อุณหภูมิที่กำหนดได้นั้น ไฮโดรเจลจำเป็นจะต้องผ่านการออกแบบให้มีกลไกตอบสนองต่ออุณหภูมิได้ ในงานวิจัยนี้ คณะวิจัยเสนอแนวคิดของไฮโดรเจลที่เตรียมจากโคพอลิเมอร์ที่ตอบสนองต่ออุณหภูมิเพื่อให้อุณหภูมิต่ำกว่าวิกฤตสารละลาย (LCST) นำไปสู่สายโซ่พอลิเมอร์ที่หดตัวทับกันเพื่อบีบสายโซ่เชื่อมขวางพอลิเมอร์และนำไปสู่การที่น้ำถูกบีบคายออกงานวิจัยนี้จึงเสนอการออกแบบโมเลกุลและการสังเคราะห์ไฮโดรเจลแบบเชื่อมขวางสองร่างแหภายใต้โครงสร้างของพอลิ(เอ็น-ไอโซพรอพิลอะคริลาไมด์)-โค-พอลิอคริลิก เอซิด งานวิจัยนี้ครอบคลุมขั้นตอนการสังเคราะห์และเตรียมไฮโดรเจลการพิสูจน์ทราบโครงสร้าง การติดตามค่า LCST รวมถึงการศึกษาสมบัติการตอบรับอุณหภูมิผ่านกรณีศึกษาของดิน
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Lui, E., and Monica L. Moya. Optimization of vascularization-­inducing hydrogel bioinks for 3D bioprinting. Office of Scientific and Technical Information (OSTI), September 2016. http://dx.doi.org/10.2172/1325866.

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Nock, Anthony. Silica Hydrogel and its Use in Edible Oil Processing. AOCS, November 2016. http://dx.doi.org/10.21748/lipidlibrary.40336.

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Price, Capri. Early Detection of Corrosion via Hydrogel-based Spectroelectrochemical Sensors. Portland State University Library, January 2000. http://dx.doi.org/10.15760/etd.6521.

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Molinari, Joseph F., and James F. Socks. Effects of Hyperbaric Conditions on Corneal Physiology with Hydrogel Contact Lenses. Fort Belvoir, VA: Defense Technical Information Center, October 1987. http://dx.doi.org/10.21236/ada189152.

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Rujiravanit, Ratana. Preparation and characterization of hydrogel from chitin derivative and silk fibroin. Thailand Research Fund, 2003. https://doi.org/10.58837/chula.res.2003.80.

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Natural polymer blend films composed of chitosan and silk fibroin were prepared by solution casting technique with various ratios of chitosan to silk fibroin, using glutaraldehyde as crosslinking agent. The effects of the ratio of chitosan to silk fibroin and crosslinking agent on mechanical properties, swelling behavior and drug releasing property of the blend films were studied. For the swelling behavior, the blend films exhibited a dramatic change in the degree of swelling when immersed in acidic solutions. The blend film with 80% chitosan content had the maximum degree of swelling. It appeared that crosslinking occurred in the blend films helped the films retain their three dimensional structure. In addition, FTIR spectra of the films showed evidence of hydrogen bonding interaction between chitosan and silk fibroin. Drug release characteristics of the blend films with various blend compositions were investigated using theophylline, diclofenac sodium, amoxicillin trihydrate and salicylic acid as model drugs. It was found that the blend film with 80% chitosan content showed the maximum amount of drug release at pH 2.0 for all types of drugs. The maximum amount of salicylic acid, theophylline, diclogenac sodium and amoxicillin release from blend films with 80% chitosan content at pH 2.0 were 92.7%, 81.1%, 76.6%, and 37.2%, respectively. Drug release properties of the films with various blend compositions were also investigated using a modified Franz Diffusion cell and pig skin was used as material representing human skin.
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