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Journal articles on the topic 'Hydrogel de polysaccharide'

Author: Grafiati

Published: 4 June 2021

Last updated: 6 February 2022

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1

Ye, Jing, Gang Yang, Jing Zhang, et al. "Preparation and characterization of gelatin-polysaccharide composite hydrogels for tissue engineering." PeerJ 9 (March 15, 2021): e11022. http://dx.doi.org/10.7717/peerj.11022.

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Background Tissue engineering, which involves the selection of scaffold materials, presents a new therapeutic strategy for damaged tissues or organs. Scaffold design based on blends of proteins and polysaccharides, as mimicry of the native extracellular matrix, has recently become a valuable strategy for tissue engineering. Objective This study aimed to construct composite hydrogels based on natural polymers for tissue engineering. Methods Composite hydrogels based on blends of gelatin with a polysaccharide component (chitosan or alginate) were produced and subsequently enzyme crosslinked. The

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2

Choi, Jae Hyuk, Donghee Son, and Mikyung Shin. "Sundew-Inspired Adhesive Hydrogel Threads through Reversible Complexation of Polyphenol and Boronic Acid." Applied Sciences 11, no. 18 (2021): 8591. http://dx.doi.org/10.3390/app11188591.

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Adhesive hydrogels have been utilized as tissue sealants, hemostatic agents, and wound dressings, with the aim of replacing conventional sutures. To prevent immune response and serious inflammation from those hydrogels after sealing, natural biocompatible polysaccharides are widely used as a component of the hydrogels. However, the weak mechanical strength, insufficient adhesiveness, and rapid dissociation of the hydrogels necessitates additional suturing at the wound site. In this study, we report on a solid polysaccharide thread reversibly crosslinked with boronic acid-polyphenol complexatio

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3

Heidarian, Pejman, Hossein Yousefi, Akif Kaynak, et al. "Dynamic Nanohybrid-Polysaccharide Hydrogels for Soft Wearable Strain Sensing." Sensors 21, no. 11 (2021): 3574. http://dx.doi.org/10.3390/s21113574.

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Electroconductive hydrogels with stimuli-free self-healing and self-recovery (SELF) properties and high mechanical strength for wearable strain sensors is an area of intensive research activity at the moment. Most electroconductive hydrogels, however, consist of static bonds for mechanical strength and dynamic bonds for SELF performance, presenting a challenge to improve both properties into one single hydrogel. An alternative strategy to successfully incorporate both properties into one system is via the use of stiff or rigid, yet dynamic nano-materials. In this work, a nano-hybrid modifier d

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Zhang, Chen, Yanan He, Zhejie Chen, Jinfeng Shi, Yan Qu, and Jinming Zhang. "Effect of Polysaccharides from Bletilla striata on the Healing of Dermal Wounds in Mice." Evidence-Based Complementary and Alternative Medicine 2019 (October 24, 2019): 1–9. http://dx.doi.org/10.1155/2019/9212314.

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Bletilla striata has been largely used in traditional folk medicine in China as a wound healing agent and to treat gastritis and several other health problems. Some studies have shown that plant polysaccharides may have the ability to promote wound healing. The aim of this work was to evaluate the wound healing activity of the polysaccharide extracted from Bletilla striata. Firstly, a Bletilla striata polysaccharide was extracted by water extraction and alcohol precipitation and characterized by Fourier transform infrared spectroscopy. The Bletilla striata polysaccharide was then tested for ce

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5

McCarthy, Pumtiwitt C., Yongchao Zhang, and Fasil Abebe. "Recent Applications of Dual-Stimuli Responsive Chitosan Hydrogel Nanocomposites as Drug Delivery Tools." Molecules 26, no. 16 (2021): 4735. http://dx.doi.org/10.3390/molecules26164735.

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Polysaccharides are a versatile class of macromolecules that are involved in many biological interactions critical to life. They can be further modified for added functionality. Once derivatized, these polymers can exhibit new chemical properties that can be further optimized for applications in drug delivery, wound healing, sensor development and others. Chitosan, derived from the N-deacetylation of chitin, is one example of a polysaccharide that has been functionalized and used as a major component of polysaccharide biomaterials. In this brief review, we focus on one aspect of chitosan’s uti

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6

Hu, Hao, Chao Huang, Massimiliano Galluzzi, et al. "Editing the Shape Morphing of Monocomponent Natural Polysaccharide Hydrogel Films." Research 2021 (June 3, 2021): 1–12. http://dx.doi.org/10.34133/2021/9786128.

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Shape-morphing hydrogels can be widely used to develop artificial muscles, reconfigurable biodevices, and soft robotics. However, conventional approaches for developing shape-morphing hydrogels highly rely on composite materials or complex manufacturing techniques, which limit their practical applications. Herein, we develop an unprecedented strategy to edit the shape morphing of monocomponent natural polysaccharide hydrogel films via integrating gradient cross-linking density and geometry effect. Owing to the synergistic effect, the shape morphing of chitosan (CS) hydrogel films with gradient

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7

Wang, Rong, Xinhua Wan, and Jie Zhang. "Multi-stimuli-responsive induced chirality of polyoxometalates in natural polysaccharide hydrogels." Chemical Communications 55, no. 32 (2019): 4711–14. http://dx.doi.org/10.1039/c9cc01981b.

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Multi-stimuli-responsive induced circular dichroism of polyoxometalates was realized in natural polysaccharide hydrogels. The extrinsic chiral factors rather than the intrinsic chirality of the polyoxometalates were dominant in κ-carrageenan hydrogel hybrids.

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8

Chen, Nifeng, Huina Zhang, Yinmao Dong, and Li Li. "Polysaccharide Hydrogel and its Application Analysis." Asian Journal of Beauty and Cosmetology 18, no. 1 (2020): 129–35. http://dx.doi.org/10.20402/ajbc.2020.0004.

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9

SMEDS, KIMBERLY A., ANNE PFISTER-SERRES, DIANE L. HATCHELL, and MARK W. GRINSTAFF. "SYNTHESIS OF A NOVEL POLYSACCHARIDE HYDROGEL." Journal of Macromolecular Science, Part A 36, no. 7-8 (1999): 981–89. http://dx.doi.org/10.1080/10601329908951194.

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10

SMEDS, KIMBERLY, ANNE PFISTER-SERRES, DIANE HATCHELL, and MARK GRINSTAFF. "SYNTHESIS OF A NOVEL POLYSACCHARIDE HYDROGEL." Journal of Macromolecular Science, Part A- Pure and Applied Chemistry 36, no. 7&8 (1999): 981–89. http://dx.doi.org/10.1081/ma-100101577.

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11

Byrkina, T. S., K. P. Loveckij, and N. D. Oltarzhevskaya. "Methods of Accelerated Prediction of The Shelf Life of Medical Polysaccharide-Based Hydrogels." Biomedical Chemistry: Research and Methods 1, no. 4 (2018): e00081. http://dx.doi.org/10.18097/bmcrm00081.

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The paper describes an accelerated technique for determining the warranty period for the hydrogel-based polymer materials used for medical purposes. It deals with the technological production stages of hydrogel therapeutic materials “Kolegel” based on a polysaccharide of sodium alginate. On these stages deterioration of the material properties might lead to reduction of the shelf life of products (using natural raw materials, sterilization). The article introduces the ways to reduce this negative effect and subsequently increase the warranty period of the medical product by adding stabilizing

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12

Аbilova, Guzel, Danelya Makhayeva, Galiya Irmukhametova, and Vitaliy Khutoryanskiy. "Chitosan based hydrogels and their use in medicine." Chemical Bulletin of Kazakh National University, no. 2 (June 5, 2020): 16–28. http://dx.doi.org/10.15328/cb1100.

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Chitosan is a natural biopolymer, polysaccharide, a product of chitin deacetylation. Chitosan is a non-toxic, biocompatible and biodegradable polymer with high biological activity and stability in the environment. In addition, chitosan is obtained from natural renewable resources and is an inexpensive substance. Due to all these properties, chitosan is widely used in practical medicine, for example, in the form of hydrogel dosage forms in combination with natural and synthetic polymers. This review is focused on polymer hydrogel materials based on chitosan. Special attention is paid to the pre

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13

Davis, Bryce, and Warren J. Goux. "Single-Laboratory Validation of an NMR Method for the Determination of Aloe Vera Polysaccharide in Pharmaceutical Formulations." Journal of AOAC INTERNATIONAL 92, no. 6 (2009): 1607–16. http://dx.doi.org/10.1093/jaoac/92.6.1607.

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Abstract This report presents a single-laboratory-validated NMR method for determining the quantity of aloe vera polysaccharide in product formulations. The ratio of signal intensities of the acetyl methyl protons to methyl protons of an internal reference varied linearly with concentration (r2 &gt; 0.99) with a lower LOQ of 0.2 g/100 mL for two commercial aloe polysaccharide standards, Acemannan Hydrogel (AH) and Immuno10 (I10). The assay was used to quantify these standards in two nonacetylated polysaccharide matrices, dextrin and arabinogalactan, and in a pharmaceutical product. The con

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14

Wei, Zhao, Jian Hai Yang, Zhen Qi Liu, et al. "Novel Biocompatible Polysaccharide-Based Self-Healing Hydrogel." Advanced Functional Materials 25, no. 9 (2015): 1352–59. http://dx.doi.org/10.1002/adfm.201401502.

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15

Zimmer, Jochen. "Structural features underlying recognition and translocation of extracellular polysaccharides." Interface Focus 9, no. 2 (2019): 20180060. http://dx.doi.org/10.1098/rsfs.2018.0060.

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Essentially all living systems produce complex carbohydrates as an energy source, structural component, protective coat or adhesive for cell attachment. Many polysaccharides are displayed on the cell surface or are threaded through proteinaceous tunnels for degradation. Dictated by their chemical composition and mode of polymerization, the physical properties of complex carbohydrates differ substantially, from amphipathic water-insoluble polymers to highly hydrated hydrogel-forming macromolecules. Accordingly, diverse recognition and translocation mechanisms evolved to transport polysaccharide

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16

Gao, Zhi Yuan, Jian Xin Jiang, and Ning Yin. "Synthesis and Characterizations of Thermo-Sensitive Graft-Polymer Hydrogel from Gleditsia sinensis polysaccharide." Journal of Biomimetics, Biomaterials and Tissue Engineering 9 (January 2011): 57–68. http://dx.doi.org/10.4028/www.scientific.net/jbbte.9.57.

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The thermo-sensitive graft-polymer of Gleditsia Sinensis polysaccharide with N-Isopropyl Acrylamide (NIPAM) was prepared and cross linked with glutaraldehyde to form the hydrogel. The effect of reaction conditions on the graft rate and gel strength of Gleditsia Sinesis Polysaccharide-g-NIPAM was evaluated. The graft rate of Gleditsia Sinensis polysaccharide reached the highest value with temperature of 75°C, reaction time of 5 hours and initiator of 0.025% (ratio of initiator to hydrogel, w/w) respectively. The gel strength of hydrogel, generated by the graft-polymer using glutaraldehyde as a

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17

Muşat, Viorica, Elena Maria Anghel, Agripina Zaharia, et al. "A Chitosan–Agarose Polysaccharide-Based Hydrogel for Biomimetic Remineralization of Dental Enamel." Biomolecules 11, no. 8 (2021): 1137. http://dx.doi.org/10.3390/biom11081137.

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Developing multifunctional systems for the biomimetic remineralization of human enamel is a challenging task, since hydroxyapatite (HAP) rod structures of tooth enamel are difficult to replicate artificially. The paper presents the first report on the simultaneous use of chitosan (CS) and agarose (A) in a biopolymer-based hydrogel for the biomimetic remineralization of an acid-etched native enamel surface during 4–10-day immersion in artificial saliva with or without (control group) fluoride. Scanning electron microscopy coupled with energy-dispersive X-ray spectrometry, Fourier transform infr

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18

Sarker, Bapi, Raminder Singh, Tobias Zehnder, et al. "Macromolecular interactions in alginate–gelatin hydrogels regulate the behavior of human fibroblasts." Journal of Bioactive and Compatible Polymers 32, no. 3 (2016): 309–24. http://dx.doi.org/10.1177/0883911516668667.

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Due to the presence of tripeptide arginine–glycine–aspartic acid, gelatin is considered a very promising additive material to improve the cytocompatibility of alginate-based hydrogels. Two different strategies, physical blending and chemical crosslinking with gelatin, are used in this study to modify alginate hydrogel. As the intermolecular interactions between the polysaccharide and protein in the resulting physically blended and chemically crosslinked hydrogels are different, significant differences in the properties of these hydrogel types, regarding especially their surface topography, deg

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19

Tai, Chia, Soukaina Bouissil, Enkhtuul Gantumur, et al. "Use of Anionic Polysaccharides in the Development of 3D Bioprinting Technology." Applied Sciences 9, no. 13 (2019): 2596. http://dx.doi.org/10.3390/app9132596.

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Three-dimensional (3D) bioprinting technology is now one of the best ways to generate new biomaterial for potential biomedical applications. Significant progress in this field since two decades ago has pointed the way toward use of natural biopolymers such as polysaccharides. Generally, these biopolymers such as alginate possess specific reactive groups such as carboxylate able to be chemically or enzymatically functionalized to generate very interesting hydrogel structures with biomedical applications in cell generation. This present review gives an overview of the main natural anionic polysa

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20

Kadokawa, Jun-ichi. "Enzymatic preparation of functional polysaccharide hydrogels by phosphorylase catalysis." Pure and Applied Chemistry 90, no. 6 (2018): 1045–54. http://dx.doi.org/10.1515/pac-2017-0802.

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Abstract This article reviews enzymatic preparation of functional polysaccharide hydrogels by means of phosphorylase-catalyzed enzymatic polymerization. A first topic of this review deals with the synthesis of amylose-grafted polymeric materials and their formation of hydrogels, composed of abundant natural polymeric main-chains, such as chitosan, cellulose, xantham gum, carboxymethyl cellulose, and poly(γ-glutamic acid). Such synthesis was achieved by combining the phosphorylase-catalyzed enzymatic polymerization forming amylose with the appropriate chemical reaction (chemoenzymatic method).

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21

Whitfield, Colette J., Alice M. Banks, Gema Dura, et al. "Cell-free protein synthesis in hydrogel materials." Chemical Communications 56, no. 52 (2020): 7108–11. http://dx.doi.org/10.1039/d0cc02582h.

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22

Chen, Jiayao, Minfeng Li, Wei Hong, Yuanjun Xia, Jingjing Lin, and Xudong Chen. "Bioinspired interconnected hydrogel capsules for enhanced catalysis." RSC Advances 8, no. 65 (2018): 37050–56. http://dx.doi.org/10.1039/c8ra07037g.

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23

Muhammad, Gulzar, Muhammad Ajaz Hussain, Muhammad Umer Ashraf, Muhammad Tahir Haseeb, Syed Zajif Hussain, and Irshad Hussain. "Polysaccharide based superabsorbent hydrogel from Mimosa pudica: swelling–deswelling and drug release." RSC Advances 6, no. 28 (2016): 23310–17. http://dx.doi.org/10.1039/c5ra23088h.

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24

Tang, Yuqin, Xueqin Cai, Yingying Xiang, Yu Zhao, Xinge Zhang, and Zhongming Wu. "Cross-linked antifouling polysaccharide hydrogel coating as extracellular matrix mimics for wound healing." Journal of Materials Chemistry B 5, no. 16 (2017): 2989–99. http://dx.doi.org/10.1039/c6tb03222b.

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25

Luo, Yi, Huajia Diao, Suhua Xia, Lei Dong, Jiangning Chen, and Junfeng Zhang. "A physiologically active polysaccharide hydrogel promotes wound healing." Journal of Biomedical Materials Research Part A 94A, no. 1 (2010): 193–204. http://dx.doi.org/10.1002/jbm.a.32711.

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26

Marquis, M., J. Davy, B. Cathala, A. Fang, and D. Renard. "Microfluidics assisted generation of innovative polysaccharide hydrogel microparticles." Carbohydrate Polymers 116 (February 2015): 189–99. http://dx.doi.org/10.1016/j.carbpol.2014.01.083.

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27

Zheng, Xinyu, Yang Gao, Xiuyan Ren, and Guanghui Gao. "Polysaccharide-tackified composite hydrogel for skin-attached sensors." Journal of Materials Chemistry C 9, no. 9 (2021): 3343–51. http://dx.doi.org/10.1039/d0tc05589a.

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28

Głąb, Magdalena, Anna Drabczyk, Sonia Kudłacik-Kramarczyk, et al. "Starch Solutions Prepared under Different Conditions as Modifiers of Chitosan/Poly(aspartic acid)-Based Hydrogels." Materials 14, no. 16 (2021): 4443. http://dx.doi.org/10.3390/ma14164443.

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Recently, there has been great interest in the application of polysaccharides in the preparation of diverse biomaterials which result from their biocompatibility, biodegradability and biological activity. In this work, the investigations on chitosan/poly(aspartic acid)-based hydrogels modified with starch were described. Firstly, a series of hydrogel matrices was prepared and investigated to characterize their swelling properties, structure via FT-IR spectroscopy, elasticity and tensile strength using the Brookfield texture analyzer as well as their impact on simulated physiological liquids. H

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29

Chowdhury, Md Najmul Kabir, Ahmad Fauzi Ismail, Mohammad Dalour Hossen Beg, Gurumurthy Hegde, and Rasool Jamshidi Gohari. "Polyvinyl alcohol/polysaccharide hydrogel graft materials for arsenic and heavy metal removal." New Journal of Chemistry 39, no. 7 (2015): 5823–32. http://dx.doi.org/10.1039/c5nj00509d.

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30

Gopalakrishnan Usha, Preethi, Sreekutty Jalajakumari, Unnikrishnan Babukuttan Sheela, et al. "Engineering cartilage graft using mesenchymal stem cell laden polyacrylamide-galactoxyloglucan hydrogel for transplantation." Journal of Biomaterials Applications 36, no. 3 (2021): 541–51. http://dx.doi.org/10.1177/08853282211019521.

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Hydrogels are reported to have various biomedical field applications, and many reports also suggest that soft gels promote stem cell differentiation. Chondrogenic differentiation of mesenchymal stem cells (MSC) is significant in articular cartilage repair. This study focuses on polysaccharide-based hydrogels which enhance chondrocyte lineage differentiation of MSC when grown in the hydrogels. This study implies that the prepared hydrogels promote specific lineage without any external chemical induction factors. The techniques, including immunofluorescence and functional assays to assess the di

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31

Cao, Jinying, Ling Xiao, and Xiaowen Shi. "Injectable drug-loaded polysaccharide hybrid hydrogels for hemostasis." RSC Advances 9, no. 63 (2019): 36858–66. http://dx.doi.org/10.1039/c9ra07116d.

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32

Yu, Yibin, Hao Pan, Yingying Wang, et al. "New insights into an innovative Auricularia auricular polysaccharide pH-sensitive hydrogel for controlled protein drug delivery." RSC Advances 6, no. 64 (2016): 59794–99. http://dx.doi.org/10.1039/c6ra06463a.

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33

Rossi, B., V. Venuti, F. D'Amico, et al. "Water and polymer dynamics in a model polysaccharide hydrogel: the role of hydrophobic/hydrophilic balance." Physical Chemistry Chemical Physics 17, no. 2 (2015): 963–71. http://dx.doi.org/10.1039/c4cp04045g.

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34

Souza, Jaqueline F., Gabriel P. Costa, Rafael Luque, Diego Alves, and André R. Fajardo. "Polysaccharide-based superporous hydrogel embedded with copper nanoparticles: a green and versatile catalyst for the synthesis of 1,2,3-triazoles." Catalysis Science & Technology 9, no. 1 (2019): 136–45. http://dx.doi.org/10.1039/c8cy01796d.

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35

Ashiri, Samira, and Ebrahim Mehdipour. "Preparation of a novel palladium catalytic hydrogel based on graphene oxide/chitosan NPs and cellulose nanowhiskers." RSC Advances 8, no. 57 (2018): 32877–85. http://dx.doi.org/10.1039/c8ra06623j.

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36

Roh, Hyun-Ho, Hyun-Seung Kim, Chunggoo Kim, and Kuen-Yong Lee. "3D Printing of Polysaccharide-Based Self-Healing Hydrogel Reinforced with Alginate for Secondary Cross-Linking." Biomedicines 9, no. 9 (2021): 1224. http://dx.doi.org/10.3390/biomedicines9091224.

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Three-dimensional (3D) bioprinting has been attractive for tissue and organ regeneration with the possibility of constructing biologically functional structures useful in many biomedical applications. Autonomous healing of hydrogels composed of oxidized hyaluronate (OHA), glycol chitosan (GC), and adipic acid dihydrazide (ADH) was achieved after damage. Interestingly, the addition of alginate (ALG) to the OHA/GC/ADH self-healing hydrogels was useful for the dual cross-linking system, which enhanced the structural stability of the gels without the loss of their self-healing capability. Various

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37

Makuuchi, K. "Critical review of radiation processing of hydrogel and polysaccharide." Radiation Physics and Chemistry 79, no. 3 (2010): 267–71. http://dx.doi.org/10.1016/j.radphyschem.2009.10.011.

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38

Xiao, Congming. "ChemInform Abstract: Preparation and Properties of Polysaccharide-Based Hydrogel." ChemInform 41, no. 49 (2010): no. http://dx.doi.org/10.1002/chin.201049251.

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39

Cha, Chaenyung, Eleni Antoniadou, Minkyung Lee, et al. "Tailoring Hydrogel Adhesion to Polydimethylsiloxane Substrates Using Polysaccharide Glue." Angewandte Chemie International Edition 52, no. 27 (2013): 6949–52. http://dx.doi.org/10.1002/anie.201302925.

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40

Cha, Chaenyung, Eleni Antoniadou, Minkyung Lee, et al. "Tailoring Hydrogel Adhesion to Polydimethylsiloxane Substrates Using Polysaccharide Glue." Angewandte Chemie 125, no. 27 (2013): 7087–90. http://dx.doi.org/10.1002/ange.201302925.

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41

Jeong, Keun-Seung, Ho-Joong Kim, Hwa-Lim Lim, et al. "Synthesis and Biocompatibility of Silicone Hydrogel Functionalized with Polysaccharide." Bulletin of the Korean Chemical Society 36, no. 6 (2015): 1649–53. http://dx.doi.org/10.1002/bkcs.10315.

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42

Nie, Jingyi, Boying Pei, Zhengke Wang, and Qiaoling Hu. "Construction of ordered structure in polysaccharide hydrogel: A review." Carbohydrate Polymers 205 (February 2019): 225–35. http://dx.doi.org/10.1016/j.carbpol.2018.10.033.

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43

Bogdanova, L. R., A. M. Rogov, O. S. Zueva, and Yu F. Zuev. "Lipase enzymatic microreactor in polysaccharide hydrogel: structure and properties." Russian Chemical Bulletin 68, no. 2 (2019): 400–404. http://dx.doi.org/10.1007/s11172-019-2399-1.

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44

Duval, Sophie, Cheryl Chung, and David Julian McClements. "Protein-Polysaccharide Hydrogel Particles Formed by Biopolymer Phase Separation." Food Biophysics 10, no. 3 (2015): 334–41. http://dx.doi.org/10.1007/s11483-015-9396-1.

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45

Wang, Chunming, Jinghua Hao, Feng Zhang, Kai Su, and Dong-An Wang. "RNA extraction from polysaccharide-based cell-laden hydrogel scaffolds." Analytical Biochemistry 380, no. 2 (2008): 333–34. http://dx.doi.org/10.1016/j.ab.2008.06.005.

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46

Hinton, Thomas J., Quentin Jallerat, Rachelle N. Palchesko, et al. "Three-dimensional printing of complex biological structures by freeform reversible embedding of suspended hydrogels." Science Advances 1, no. 9 (2015): e1500758. http://dx.doi.org/10.1126/sciadv.1500758.

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We demonstrate the additive manufacturing of complex three-dimensional (3D) biological structures using soft protein and polysaccharide hydrogels that are challenging or impossible to create using traditional fabrication approaches. These structures are built by embedding the printed hydrogel within a secondary hydrogel that serves as a temporary, thermoreversible, and biocompatible support. This process, termed freeform reversible embedding of suspended hydrogels, enables 3D printing of hydrated materials with an elastic modulus <500 kPa including alginate, collagen, and fibrin. Computer-a

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47

Milojević, Marko, Gregor Harih, Boštjan Vihar, et al. "Hybrid 3D Printing of Advanced Hydrogel-Based Wound Dressings with Tailorable Properties." Pharmaceutics 13, no. 4 (2021): 564. http://dx.doi.org/10.3390/pharmaceutics13040564.

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Despite the extensive utilization of polysaccharide hydrogels in regenerative medicine, current fabrication methods fail to produce mechanically stable scaffolds using only hydrogels. The recently developed hybrid extrusion-based bioprinting process promises to resolve these current issues by facilitating the simultaneous printing of stiff thermoplastic polymers and softer hydrogels at different temperatures. Using layer-by-layer deposition, mechanically advantageous scaffolds can be produced by integrating the softer hydrogel matrix into a stiffer synthetic framework. This work demonstrates t

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48

Xu, Wenjin, Xianran He, Min Zhong, Xianming Hu, and Yuling Xiao. "A novel pH-responsive hydrogel based on natural polysaccharides for controlled release of protein drugs." RSC Advances 5, no. 5 (2015): 3157–67. http://dx.doi.org/10.1039/c4ra08147a.

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49

Patel, Jenny, and Elizabeth Barker. "EMBR-31. DEVELOPMENT OF INJECTABLE POLYSACCHARIDE HYDROGEL TO ENHANCE DRUG PENETRATION IN PEDIATRIC BRAIN TUMORS." Neuro-Oncology 23, Supplement_1 (2021): i12. http://dx.doi.org/10.1093/neuonc/noab090.048.

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Abstract Improving unacceptable low response rates and reducing acute and long-term morbidities remain significant challenges in pediatric neuro-oncology. Chemotherapy is an effective primary or adjuvant treatment for pediatric disease, but current administration approaches hinder the pharmacological activity exerted by chemotherapy treatments. Barriers in the route of drug administration and in the tumor microenvironment limit anticancer drugs from penetrating tissue efficiently and reaching all cancer cells. Strategies have been proposed to overcome these barriers with hope of leading to sus

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Chen, Yujie, Runjing Zhang, Baiqin Zheng, et al. "A Biocompatible, Stimuli-Responsive, and Injectable Hydrogel with Triple Dynamic Bonds." Molecules 25, no. 13 (2020): 3050. http://dx.doi.org/10.3390/molecules25133050.

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Injectable hydrogels have attracted growing interests as promising biomaterials for clinical applications, due to their minimum invasive implanting approach and easy-handling performance. Nevertheless, natural biomaterials-based injectable hydrogels with desirable nontoxicity are suffering from limited functions, failing to fulfill the requirements of clinical biomaterials. The development of novel injectable biomaterials with a combination of biocompatibility and adequate functional properties is a growing urgency toward biomedical applications. In this contribution, we report a simple and ef

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