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Journal articles on the topic 'Hydrogen Peroxide T-Lymphocytes'

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Published: 4 June 2021

Last updated: 16 February 2022

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1

Lv, Jingzhu, Xiaojie Zhang, Caizhi Wang, Hongtao Wang, Ting Wang, and Zhongqing Qian. "Hydrogen peroxide promotes the activation of preeclampsia peripheral T cells." Innate Immunity 24, no. 4 (2018): 203–9. http://dx.doi.org/10.1177/1753425918767305.

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Preeclampsia (PE) is a pregnancy disorder with a high mortality rate. Patients with PE exhibit systemic high oxidative stress status and inflammatory immune activation. This study aims to define the role of H2O2 in the activation of neutrophils and T lymphocytes in PE patients. CD3+/HLA-DR+ cells in blood from PE patients are remarkably increased compared with those of normal non-pregnancies or normal pregnancies, while the percentage of CD3+/CD62L+ cells is significantly reduced in PE patients compared to normal pregnancies. Furthermore, CD62L levels in granulocytes of periphery blood of PE p

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2

Ryazantseva, N. V., E. A. Stepovaya, E. V. Konovalova, et al. "Oxidative stress modeling in the blood lymphocytes in vitro to examine the Jurkat line tumor cells apoptosis." Kazan medical journal 94, no. 5 (2013): 736–40. http://dx.doi.org/10.17816/kmj1932.

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Aim. To experimentally select the optimum concentration of hydrogen peroxide capable of efficiently induce oxidative stress and launch the programmed death of the maximum number of lymphocytes, but not induce the necrosis. Methods. Jurkat tumor cell line (human T-lymphoblastic leukemia) lymphocytes isolated from the blood of healthy donors (15 males, 18 females) aged 18 to 25 years were the objects of the study. To confirm the object of study, blood cells typing for CD5 using flow cytometry was performed. To model the oxidative stress in vitro, blood lymphocytes were incubated in the presence

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3

Aurelius, Johan, Galia Askarieh, Ana I. Romero, Fredrik B. Thorén, Mats L. Brune, and Kristoffer Hellstrand. "CD16/FcãRIII Antigen Expression Determines Oxidative Sensitivity in Cytotoxic Lymphocyte Subsets." Blood 112, no. 11 (2008): 4921. http://dx.doi.org/10.1182/blood.v112.11.4921.4921.

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Abstract Oxidative stress, referring to cellular toxicity induced by reactive oxygen metabolites (ROM), has been proposed as a mechanism of immunosuppression in hematological malignant diseases. ROM produced by myeloid cells such as normal or malignant phagocytes have been shown to compromise functions of lymphocytes including natural killer (NK) cells and CD4+ or CD8+ T cells. Phagocyte-derived ROM induce downmodulation of the CD3/CD16 zeta; transduction antigen in these lymphocyte subsets with ensuing loss of function and lack of responsiveness to activating cytokines such as IL- 2. In addit

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4

Dı́az-Llera, Silvia, Andrej Podlutsky, Anne-May Österholm, Sai-Mei Hou, and Bo Lambert. "Hydrogen peroxide induced mutations at the HPRT locus in primary human T-lymphocytes." Mutation Research/Genetic Toxicology and Environmental Mutagenesis 469, no. 1 (2000): 51–61. http://dx.doi.org/10.1016/s1383-5718(00)00058-9.

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5

Chi, Xiaoqing, Xiaodan Ma, Zoushuyi Li, et al. "Protective Effect of Epigallocatechin-3-Gallate in Hydrogen Peroxide-Induced Oxidative Damage in Chicken Lymphocytes." Oxidative Medicine and Cellular Longevity 2020 (December 31, 2020): 1–15. http://dx.doi.org/10.1155/2020/7386239.

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Epigallocatechin-3-gallate (EGCG) is one of the fundamental compounds in green tea. The present study was to evaluate the protective effect of EGCG in oxidative damage and apoptosis induced by hydrogen peroxide (H2O2) in chicken lymphocytes. Results showed that preincubation of lymphocytes with EGCG significantly decreased H2O2-reduced cell viability and apoptotic cells with DNA damage, restored the H2O2-dependent reduction in total antioxidant capacity (T-AOC), glutathione peroxidase (GSH-PX), superoxide dismutase (SOD), glutathione (GSH), and glutathione disulfide (GSSG), and suppressed the

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6

Yano, Sumio, Noriko Yano, Nayra Rodriguez, et al. "Suppression of Intracellular Hydrogen Peroxide Generation and Catalase Levels in CD8+ T-Lymphocytes From HIV+ Individuals." Free Radical Biology and Medicine 24, no. 2 (1998): 349–59. http://dx.doi.org/10.1016/s0891-5849(97)00275-x.

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7

Howe, Christopher J., Michelle M. LaHair, Jill A. Maxwell та ін. "Participation of the Calcium/Calmodulin-dependent Kinases in Hydrogen Peroxide-induced IκB Phosphorylation in Human T Lymphocytes". Journal of Biological Chemistry 277, № 34 (2002): 30469–76. http://dx.doi.org/10.1074/jbc.m205036200.

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8

Romero, Ana I., Fredrik B. Thorén, Mats Brune, and Kristoffer Hellstrand. "Histamine Dihydrochloride Maintains Cytotoxic Effector T Lymphocyte Function and Viability under Conditions of Oxidative Stress." Blood 110, no. 11 (2007): 2309. http://dx.doi.org/10.1182/blood.v110.11.2309.2309.

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Abstract BACKGROUND: Malignant diseases are frequently accompanied by suppression of cytotoxic lymphocyte function, and a large body of circumstantial evidence suggests that lymphocyte suppression may have implications for disease-free survival in several hematopoietic cancers. In AML, a plethora of immunosuppressive mechanisms have been described including the production of T- and NK-cell-inhibitory factors by AML blasts, a deficient expression of activating receptors on natural killer (NK) cells, and an impaired stimulatory interaction between the CD28 antigen expressed by T cells and contac

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9

Bayer, Diana, Jonathon Jansen, and Lisa A. Beltz. "Differential Effects of Tea Extracts on Growth and Cytokine Production by Normal and Leukemic Human Leukocytes." Functional Foods in Health and Disease 2, no. 4 (2012): 72. http://dx.doi.org/10.31989/ffhd.v2i4.97.

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Background: Tea is one of the world’s most highly consumed beverages, second only to water. It is affordable and abundant and thus has great potential for improving health of those in both developed and developing areas. Green, oolong, and black teas differ in the extent of fermentation and types of bioactive polyphenols produced. Green tea and its major polyphenol decrease growth of some cancer cells and effect production of immune system cytokines. This study compares the effects of different types of tea extracts on viability and cytokine production by normal and leukemic human T lymphocyte

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10

WU, Haitao, Tomoko YOKOYAMA, Beiwei ZHU, Yasuaki SHIMOISHI, Yoshiyuki MURATA, and Yoshimasa NAKAMURA. "(−)-Epigallocatechin-3-gallate Potentiates the Cytotoxicity Induced by Benzyl Isothiocyanate and Hydrogen Peroxide in Human Jurkat T Lymphocytes." Bioscience, Biotechnology, and Biochemistry 72, no. 11 (2008): 3034–37. http://dx.doi.org/10.1271/bbb.80422.

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11

Wirleitner, Barbara, Gabriele Baier-Bitterlich, Günther Böck, Bernhard Widner, and Dietmar Fuchs. "7,8-dihydroneopterin-induced apoptosis in Jurkat T lymphocytes: a comparison with anti-Fas- and hydrogen peroxide-mediated cell death." Biochemical Pharmacology 56, no. 9 (1998): 1181–87. http://dx.doi.org/10.1016/s0006-2952(98)00168-3.

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12

Chochola, J., A. D. Strosberg, and M. Stanislawski. "Release of Hydrogen Peroxide from Human T Cell Lines and Normal Lymphocytes Co-Infected with Hiv-1 and Mycoplasma." Free Radical Research 23, no. 3 (1995): 197–212. http://dx.doi.org/10.3109/10715769509064034.

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13

Gilston, Vanessa, Marc A. Williams, Adrian C. Newland та Paul G. Winyard. "Hydrogen peroxide and tumour necrosis factor-α induce NF-κB-DNA binding in primary human T lymphocytes in addition to T cell lines". Free Radical Research 35, № 6 (2001): 681–91. http://dx.doi.org/10.1080/10715760100301201.

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14

Low, Felicia M., Mark B. Hampton, Alexander V. Peskin, and Christine C. Winterbourn. "Peroxiredoxin 2 functions as a noncatalytic scavenger of low-level hydrogen peroxide in the erythrocyte." Blood 109, no. 6 (2006): 2611–17. http://dx.doi.org/10.1182/blood-2006-09-048728.

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AbstractPeroxiredoxin 2 (Prx2), a thiol-dependent peroxidase, is the third most abundant protein in the erythrocyte, and its absence in knock-out mice gives rise to hemolytic anemia. We have found that in human erythrocytes, Prx2 was extremely sensitive to oxidation by H2O2, as dimerization was observed after exposure of 5 × 106 cells/mL to 0.5 μM H2O2. In contrast to Prx2 in Jurkat T lymphocytes, Prx2 was resistant to overoxidation (oxidation of the cysteine thiol to a sulfinic/sulfonic acid) in erythrocytes. Reduction of dimerized Prx2 in the erythrocyte occurred very slowly, with reversal o

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15

Palyvoda, K., A. Samoylenko, L. Drobot, O. Matyshevska, and P. Scharff. "Protective effects of C60fullerenes on staurosporine-, cytosine arabinoside- and hydrogen peroxide-induced cell death of normal but not of transformed T lymphocytes." Materialwissenschaft und Werkstofftechnik 40, no. 4 (2009): 308–11. http://dx.doi.org/10.1002/mawe.200800447.

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16

Mattagajasingh, Subhendra N., and Hara P. Misra. "CARCINOGENIC CHROMIUM(VI) INDUCES OXIDATIVE STRESS IN CULTURED HUMAN LEUKEMIC T-LYMPHOCYTES. 1. GENERATIO OF HYDROGEN PEROXIDE DURIN INTRACELLULAR REDUCTION OF CHROMATE." Toxic Substance Mechanisms 16, no. 1 (1997): 63–80. http://dx.doi.org/10.1080/107691897229801.

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17

Wolf, Gabriele, Nicole Aumann, Marta Michalska та ін. "Peroxiredoxin III protects pancreatic β cells from apoptosis". Journal of Endocrinology 207, № 2 (2010): 163–75. http://dx.doi.org/10.1677/joe-09-0455.

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Type 1 diabetes mellitus is characterized by a progressive autoimmune destruction of insulin-producing β cells. Macrophages and T lymphocytes release cytokines, which induce the synthesis of oxygen and nitrogen radicals in the pancreatic islets. The resulting cellular and mitochondrial damage promotes β cell death. β cells are very sensitive to the autoimmune free radical-dependent attack due to their low content of antioxidant enzymes such as glutathione peroxidase and catalase. A focal point of β cell protection should be the control of the mitochondrial redox status, which will result in th

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18

Mohamed, Hager, Eric Gebski, Rufranshell Reyes, et al. "Differential Effect of Non-Thermal Plasma RONS on Two Human Leukemic Cell Populations." Cancers 13, no. 10 (2021): 2437. http://dx.doi.org/10.3390/cancers13102437.

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Non-thermal plasma application to cancer cells is known to induce oxidative stress, cytotoxicity and indirect immunostimulatory effects on antigen presenting cells (APCs). The purpose of this study was to evaluate the responses of two leukemic cell lines—Jurkat T lymphocytes and THP-1 monocytes—to NTP-generated reactive oxygen and nitrogen species (RONS). Both cell types depleted hydrogen peroxide, but THP-1 cells neutralized it almost immediately. Jurkat cells transiently blunted the frequency-dependent increase in nitrite concentrations in contrast to THP-1 cells, which exhibited no immediat

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19

Borchers, Michael T., Nathaniel L. Harris, Scott C. Wesselkamper, Mark Vitucci, and David Cosman. "NKG2D ligands are expressed on stressed human airway epithelial cells." American Journal of Physiology-Lung Cellular and Molecular Physiology 291, no. 2 (2006): L222—L231. http://dx.doi.org/10.1152/ajplung.00327.2005.

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Immune surveillance of the airways is critical to maintain the integrity and health of the lung. We have identified a family of ligands expressed on the surface of stressed airway epithelial cells whose function is to bind the NKG2D-activating receptor found on several pulmonary lymphocytes, including natural killer cells, γδ+ T cells, and CD8+ T cells. We employed real-time PCR and flow cytometry in normal and transformed airway epithelial cell to demonstrate that major histocompatibility complex class I chain-related (MIC) B and the UL-16 binding protein (ULBP) ligands (ULBP1–4) are ubiquito

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20

Tsao, Tien-Ping, Jenn-Haung Lai, Shih-Ping Yang, et al. "Suppression of tissue necrosis factor-alpha or hydrogen peroxide-activated primary human T lymphocytes by Ginkgo biloba extract through down-regulation of activator protein-1 signal transduction." Phytomedicine 15, no. 3 (2008): 170–76. http://dx.doi.org/10.1016/j.phymed.2007.03.016.

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21

Peters, S. E., G. K. Paterson, E. S. D. Bandularatne, et al. "Salmonella enterica Serovar Typhimurium trxA Mutants Are Protective against Virulent Challenge and Induce Less Inflammation than the Live-Attenuated Vaccine Strain SL3261." Infection and Immunity 78, no. 1 (2009): 326–36. http://dx.doi.org/10.1128/iai.00768-09.

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ABSTRACT In Salmonella enterica serovar Typhimurium, trxA encodes thioredoxin 1, a small, soluble protein with disulfide reductase activity, which catalyzes thiol disulfide redox reactions in a variety of substrate proteins. Thioredoxins are involved as antioxidants in defense against oxidative stresses, such as exposure to hydrogen peroxide and hydroxyl radicals. We have made a defined, complete deletion of trxA in the mouse-virulent S. Typhimurium strain SL1344 (SL1344 trxA), replacing the gene with a kanamycin resistance gene cassette. SL1344 trxA was attenuated for virulence in BALB/c mice

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22

Nurrahman, Nurrahman, and Nurhidajah Nurhidajah. "PENGARUH KONSUMSI TEMPE KEDELAI HITAM TERHADAP AKTIVITAS MAKROFAG DAN KADAR INTERLEUKIN 1(IL-1) PADA TIKUS SECARA IN VIVO The Effect of Black Soybean Tempe Consumption on Activity of Macrofages and Levels of IL-1 in Rat, in vivo." Jurnal Agritech 35, no. 03 (2015): 294. http://dx.doi.org/10.22146/agritech.9340.

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Black soybean tempe diet could increase the stimulation index of proliferation T cells, lymphocytes durability of hydrogen peroxide and the enzyme activity of SOD.The purpose of this study was to determine the effect of black soybean tempe consumption on on the activity of macrophages and the levels of IL-1 in rat in vivo. A total of 30 ratswere grouped into 5 (five), each group of rats were 6. For 30 days each group was maintained by administering a standard diet and diet plus black soybean tempe flour (25, 50, 75 and 100% instead of casein). After the peritoneal fluid was taken to be used fo

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23

Los, Marek, Wulf Dröge, Kirstin Stricker, Patrick A. Baeuerle, and Klaus Schulze-Osthoff. "Hydrogen peroxide as a potent activator of T lymphocyte functions." European Journal of Immunology 25, no. 1 (1995): 159–65. http://dx.doi.org/10.1002/eji.1830250127.

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24

Lieser, M. J., R. A. Kozol, and S. D. Tennenberg. "Interferon-gamma primes neutrophil-mediated gastric surface cell cytotoxicity." American Journal of Physiology-Gastrointestinal and Liver Physiology 268, no. 5 (1995): G843—G848. http://dx.doi.org/10.1152/ajpgi.1995.268.5.g843.

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The T lymphocyte product interferon-gamma (IFN-gamma) upregulates or primes polymorphonuclear leukocyte (PMN) oxidative responses to the receptor-initiated stimulant N-formyl-methionyl-leucyl-phenylalanine (FMLP) but not to the transduction-mediated stimulant phorbol myristate acetate (PMA). We sought a functional correlation between IFN-gamma-induced oxidative priming of PMNs and PMN-mediated cytotoxicity, using an in vitro assay of 51Cr release from rabbit gastric surface cells. Compared with control PMNs, IFN-gamma-primed PMNs exhibited a significant increase in cytotoxicity when stimulated

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25

Bishop, C. J., C. M. Rzepczyk, D. Stenzel, and K. Anderson. "The role of reactive oxygen metabolites in lymphocyte-mediated cytolysis." Journal of Cell Science 87, no. 3 (1987): 473–81. http://dx.doi.org/10.1242/jcs.87.3.473.

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To examine the possible role of reactive oxygen metabolites in lymphocyte-mediated cytolysis, the morphology of cell death following the exposure of cells to reactive oxygen metabolites in vitro was compared with the morphology of cell-mediated killing in vitro of tumour cells by natural killer (NK) cells. Ultrastructural examination of human tumour cells that were dying following incubation for 60 min with the oxygen metabolite generating systems, xanthine-xanthine oxidase or t-butylhydroperoxide, showed that cell death in both instances was exclusively by necrosis. It was unclear which oxyge

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26

Ball, Jennifer A., Isabella Vlisidou, Matthew D. Blunt, Will Wood, and Stephen G. Ward. "Hydrogen Peroxide Triggers a Dual Signaling Axis To Selectively Suppress Activated Human T Lymphocyte Migration." Journal of Immunology 198, no. 9 (2017): 3679–89. http://dx.doi.org/10.4049/jimmunol.1600868.

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27

Freed, Brian M. "Inhibition of Early Events in the Human T-Lymphocyte Response to Mitogens and Alloantigens by Hydrogen Peroxide." Archives of Surgery 122, no. 1 (1987): 99. http://dx.doi.org/10.1001/archsurg.1987.01400130105016.

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28

Emberesh, Myesa, Katie Giger Seu, Sana Emberesh, et al. "Peroxiredoxin II (PRDX2) Is a Novel Candidate Gene for Congenital Dyserythropoietic Anemia." Blood 132, Supplement 1 (2018): 3605. http://dx.doi.org/10.1182/blood-2018-99-120056.

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Abstract CDAR (ClinicalTrials.gov Identifier: NCT02964494), a registry for patients with Congenital Dyserythropoietic Anemia (CDA) in North America, has been created with the goal to provide a longitudinal database and associated biorepository to facilitate natural history studies and research on the molecular pathways involved in the pathogenesis of CDAs. A 1 y.o. female patient with non-immune hemolytic anemia with suboptimal reticulocytosis, requiring frequent transfusions, and with the pathologic diagnosis of CDA was enrolled in CDAR. Her father had a similar phenotypical presentation in e

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29

Pollard, K., D. Lunny, C. S. Holgate, P. Jackson, and C. C. Bird. "Fixation, processing, and immunochemical reagent effects on preservation of T-lymphocyte surface membrane antigens in paraffin-embedded tissue." Journal of Histochemistry & Cytochemistry 35, no. 11 (1987): 1329–38. http://dx.doi.org/10.1177/35.11.3309048.

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Fixatives, fixation additives, paraffin processing reagents, and immunochemical reagents were investigated for effects on preservation of T-lymphocyte surface membrane antigens CD3, CD4, and CD8 in human tonsil. Individual reagent effects were assessed in frozen sections by use of monoclonal antibodies and this information was used to optimize T-cell immunostaining in paraffin sections. Harmful factors were fixation delay, fixation at acid pH, fixation and processing at temperatures above 4 degrees C, hot paraffin wax, proteolytic enzymes, methanolic hydrogen peroxide, Triton X-100, and prolon

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30

Zhang, Zhihua, Jack M. Lipman, Robert M. Diener, and Peter Thomas. "Comparative Immunotoxicity Evaluation of Amphotericin B and ABELCET®, an Amphotericin B Lipid Complex (ABLC)." International Journal of Toxicology 25, no. 6 (2006): 487–92. http://dx.doi.org/10.1080/10915810600961242.

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ABELCET®, an amphotericin B lipid complex formulation (ABLC) and an aqueous, non–lipid-containing formulation with sodium deoxycholate (AmBd), were evaluated for their potential to induce immunotoxicity in B6C3F1 female mice. ABLC was administered intravenously at doses of 1, 3, and 10 mg/kg daily for 28 days, while AmBd at 1 mg/kg was administered by the same route and duration. The effect of ABLC and AmBd on clinical signs, body weight, and spleen weight was determined. Peritoneal macrophage function was measured by phagocytosis of 51Cr-labeled chicken red blood cells and generation of hydro

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31

Prater, M. R., R. M. Gogal, B. L. Blaylock, and S. D. Holladay. "Cis-Urocanic Acid Increases Immunotoxicity and Lethality of Dermally Administered Permethrin in C57BL/6N Mice." International Journal of Toxicology 22, no. 1 (2003): 35–42. http://dx.doi.org/10.1080/10915810305070.

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Immunomodulatory effects of a single topical permethrin exposure, 5-day exposure to cis-urocanic acid (c UCA), or a combination of the two chemicals were evaluated in 4- to 5-week-old female C57BL/6N mice. Permethrin alone decreased thymic weight and cellularity. Although c UCA alone did not affect thymic end points, coexposure to topical permethrin and c UCA exacerbated the thymolytic effects of permethrin. The single topical dose of permethrin also depressed several immune responses in isolated splenic leukocytes. This included splenic T-cell proliferative response to mitogen, splenic macrop

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32

Cichocki, Frank, Karrune Woan, Cheng-Ying Wu, et al. "NK Cells Lacking CD38 Are Resistant to Oxidative Stress-Induced Death." Blood 134, Supplement_1 (2019): 3215. http://dx.doi.org/10.1182/blood-2019-124490.

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Cytolytic effector lymphocytes must contend with unfavorable microenvironments when infiltrating sites of infection or malignancy. Tumor cells typically have high levels of oxidative stress and produce reactive oxygen species (ROS) that suppress the cytotoxic functions of both natural killer (NK) cells and CD8+ T cells. Levels of activated granulocytes that release ROS are also elevated in cancer patients. Free radicals, such as ROS, cause detrimental cellular effects including protein oxidation, lipid peroxidation and DNA damage. Chronic viral infections, including CMV, are also associated wi

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33

Lewandowski, Krzysztof, Maria Zozulińska, Adam Szczepanik, Grzegorz Dworacki, Hanna Tilgner, and Krystyna Zawilska. "Normal Sialophorine (CD43) Expression in a Thrombocytopenic and Immunodeficient Woman Carrier of Wiskott—Aldrich Syndrome." Clinical and Applied Thrombosis/Hemostasis 2, no. 2 (1996): 137–41. http://dx.doi.org/10.1177/107602969600200209.

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We report on a 24-year-old thrombocytopenic woman with a history of recurrent infections, skin and mucosal bleeding, and a member of a family with the Wiskott—Aldrich syndrome. Hemorrhagic complications occurred at age 20, when mild peripheral thrombocyto penia (38-52 g/L) was confirmed. Four male family mem bers died of infectious complications at ages ranging from 6 months to 3 years. At the time of the study, she was free of infection. Physical examination exhibited ecchymoses of skin of the legs only, and her laboratory investigations demonstrated a lack of secondary waves of platelet ag g

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34

Lahav, Meir, Orit Uziel, Hagai Reshef, Anat Ravid, and Ina Fabian. "The Role of Oxidative Stress on Telomere Shortening, Telomere Dysfunction and Damage to Telomere G- Strand Overhang - A Putative Model of Carcinogenesis in Fanconi Anemia Cells." Blood 106, no. 11 (2005): 1607. http://dx.doi.org/10.1182/blood.v106.11.1607.1607.

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Abstract Fanconi Anemia is an autosomal recessive disease characterized by various inborn abnormalities and severe genetic instability, which may lead to bone marrow failure and increased incidence of cancer. One possible explanation for this genomic instability may be the cellular hypersensitivity to oxidative stress, leading to chromosomal breaks. The goal of our study was to explore the possible oxidative damage caused by H2O2 to telomeres of Fanconi Anemia (FA) lymphocyte cell line, HSC536/N and its possible relation to carcinogenesis. We surmised that combination of oxygenative damage to

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35

Olajuyin, Ayobami Matthew, Adefunke Kafayat Olajuyin, Ziqi Wang, et al. "Anti-proliferative, antioxidant effects of methanol extract of Calotropis procera leaf on lung cancer cells (H1299) and its ameliorative effect on expression of CD146 on blood cells." Clinical Phytoscience 7, no. 1 (2021). http://dx.doi.org/10.1186/s40816-021-00289-x.

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Abstract Background Calotropis procera leaf is one of the plants commonly utilized in phytomedicine in Nigeria. The present investigation explored the use of the extracts on cell viability and apoptosis respectively. In this study, the expression of the Cluster of differentiation 146 (CD146) in the blood of lung cancer patients on regulatory T cells (Tregs) was determined. The antioxidant and anti-proliferative effects of methanol extracts of Caloropis procera leaf on lung cancer cell H1299 were investigated. Methods From the flow cytometry, the expression of the CD146+ in the T cells were eva

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