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Journal articles on the topic 'Hydrogenated Soybean Phosphatidylcholine (HSPC)'

Author: Grafiati

Published: 5 June 2025

Last updated: 2 August 2025

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1

Gaál, Anikó, Tamás M. Garay, Ildikó Horváth, et al. "Development and In Vivo Application of a Water-Soluble Anticancer Copper Ionophore System Using a Temperature-Sensitive Liposome Formulation." Pharmaceutics 12, no. 5 (2020): 466. http://dx.doi.org/10.3390/pharmaceutics12050466.

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Liposomes containing copper and the copper ionophore neocuproine were prepared and characterized for in vitro and in vivo anticancer activity. Thermosensitive PEGylated liposomes were prepared with different molar ratios of 1,2-dipalmitoyl-sn-glycero-3-phosphatidylcholine (DPPC) and hydrogenated soybean phosphatidylcholine (HSPC) in the presence of copper(II) ions. Optimal, temperature dependent drug release was obtained at 70:30 DPPC to HSPC weight ratio. Neocuproine (applied at 0.2 mol to 1 mol phospholipid) was encapsulated through a pH gradient while using unbuffered solution at pH 4.5 ins

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Srikala, Vodnala, and Sunitha Redd M. "An overview of Transethosomes: Novel nanocarrier for transdermal drug delivery system." GSC Biological and Pharmaceutical Sciences 26, no. 3 (2024): 222–31. https://doi.org/10.5281/zenodo.11057698.

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The Human skin is made of different layers and the skin will act as a barrier `and it allows the delivery of the drugs through it which is known as TDDS. The delivery of the drug through the epidermis layer of the stratum corneum is difficult as it never allows large particle-sized molecules through it. So there is a need to decrease the particle size and it can be done with new advancements in transdermal delivery by preparing Deformable vesicles which act as a nanocarrier to deliver the drug by changing their shape while transferring from the epidermis to hypodermis. The most advanced Nanoca

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3

Chrysostomou, Varvara, Aleksander Foryś, Barbara Trzebicka, Costas Demetzos, and Stergios Pispas. "Amphiphilic Copolymer-Lipid Chimeric Nanosystems as DNA Vectors." Polymers 14, no. 22 (2022): 4901. http://dx.doi.org/10.3390/polym14224901.

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Lipid-polymer chimeric (hybrid) nanosystems are promising platforms for the design of effective gene delivery vectors. In this regard, we developed DNA nanocarriers comprised of a novel poly[(stearyl methacrylate-co-oligo(ethylene glycol) methyl ether methacrylate] [P(SMA-co-OEGMA)] amphiphilic random copolymer, the cationic 1,2-dioleoyl-3-(trimethylammonium) propane (DOTAP), and the zwitterionic L-α-phosphatidylcholine, hydrogenated soybean (soy) (HSPC) lipids. Chimeric HSPC:DOTAP:P[(SMA-co-OEGMA)] nanosystems, and pure lipid nanosystems as reference, were prepared in several molar ratios of

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Kitayama, Hiroki, Yuki Takechi, Nobutake Tamai, Hitoshi Matsuki, Chikako Yomota, and Hiroyuki Saito. "Thermotropic Phase Behavior of Hydrogenated Soybean Phosphatidylcholine–Cholesterol Binary Liposome Membrane." Chemical and Pharmaceutical Bulletin 62, no. 1 (2014): 58–63. http://dx.doi.org/10.1248/cpb.c13-00587.

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5

Gaisinskaya-Kipnis, Anastasia, Sabrina Jahn, Ronit Goldberg, and Jacob Klein. "Effect of Glucosamine Sulfate on Surface Interactions and Lubrication by Hydrogenated Soy Phosphatidylcholine (HSPC) Liposomes." Biomacromolecules 15, no. 11 (2014): 4178–86. http://dx.doi.org/10.1021/bm501189g.

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6

Goldberg, Ronit, Avi Schroeder, Yechezkel Barenholz, and Jacob Klein. "Interactions between Adsorbed Hydrogenated Soy Phosphatidylcholine (HSPC) Vesicles at Physiologically High Pressures and Salt Concentrations." Biophysical Journal 100, no. 10 (2011): 2403–11. http://dx.doi.org/10.1016/j.bpj.2011.03.061.

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7

Huang, Neil K., Alice H. Lichtenstein, Gregory Matuszek, and Nirupa R. Matthan. "Comparison of Plasma Metabolome Response to Diets Enriched in Soybean and Partially-Hydrogenated Soybean Oil in Moderately Hypercholesterolemic Adults-A Pilot Study." Metabolites 13, no. 4 (2023): 474. http://dx.doi.org/10.3390/metabo13040474.

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Partially-hydrogenated fat/trans fatty acid intake has been associated with adverse effects on cardiometabolic risk factors. Comparatively unexplored is the effect of unmodified oil relative to partially-hydrogenated fat on the plasma metabolite profile and lipid-related pathways. To address this gap, we conducted secondary analyses using a subset of samples randomly selected from a controlled dietary intervention trial involving moderately hypercholesterolemic individuals. Participants (N = 10, 63 ± 8 y, BMI, 26.2 ± 4.2 kg/m2, LDL-C, 3.9 ± 0.5 mmol/L) were provided with diets enriched in soyb

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8

Ahmad, Md Iftekhar, Punet Kumar, Sangam Singh, and Nitin Kumar. "Method Development and Characterization of Liposomal Formulation of Isotretinoin." Borneo Journal of Pharmacy 4, no. 2 (2021): 117–27. http://dx.doi.org/10.33084/bjop.v4i2.1915.

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This study aims to develop a liposomal drug delivery system of isotretinoin, an acne drug-using spray drying, as a cost-effective and time-effective technique. The liposomal formulation was prepared by using spray drying; three different strategies were adopted: suspension spray drying (SSD), thin-film hydration and spray drying (TFHSD), and emulsion spray drying (ESD). Isotretinoin was 99% bound with lipid, so lipids hydrogenated soy phosphatidylcholine (HSPC), distearoyl phosphatidylglycerol (DSPG), and cholesterol were selected for the formulation development. The HSPC, DSPG, cholesterol, a

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9

Najlah, Mohammad, Ammar Said Suliman, Ibrahim Tolaymat, et al. "Development of Injectable PEGylated Liposome Encapsulating Disulfiram for Colorectal Cancer Treatment." Pharmaceutics 11, no. 11 (2019): 610. http://dx.doi.org/10.3390/pharmaceutics11110610.

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Disulfiram (DS), an anti-alcoholism medicine, shows strong anti-cancer activity in the laboratory, but the application in clinics for anti-cancer therapy has been limited by its prompt metabolism. Conventional liposomes have shown limited ability to protect DS. Therefore, the aim of this study is to develop PEGylated liposomes of DS for enhanced bio-stability and prolonged circulation. PEGylated liposomes were prepared using ethanol-based proliposome methods. Various ratios of phospholipids, namely: hydrogenated soya phosphatidylcholine (HSPC) or dipalmitoyl phosphatidylcholine (DPPC) and N-(C

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10

R. Telange, Darshan, Arun T. Patil, Amol Tatode, and Bhushan Bhoyar. "Development and Validation of UV Spectrophotometric Method for the Estimation of Kaempferol in Kaempferol: Hydrogenated Soy PhosphatidylCholine (HSPC) Complex." Pharmaceutical Methods 5, no. 1 (2014): 34–38. http://dx.doi.org/10.5530/phm.2014.1.6.

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11

Tsichlis, Ioannis, Athanasia-Paraskevi Manou, Vasiliki Manolopoulou, et al. "Development of Liposomal and Liquid Crystalline Lipidic Nanoparticles with Non-Ionic Surfactants for Quercetin Incorporation." Materials 16, no. 16 (2023): 5509. http://dx.doi.org/10.3390/ma16165509.

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The aim of the present study is the development, physicochemical characterization, and in vitro cytotoxicity evaluation of both empty and quercetin-loaded HSPC (hydrogenated soy phosphatidylcholine) liposomes, GMO (glyceryl monooleate) liquid crystalline nanoparticles, and PHYT (phytantriol) liquid crystalline nanoparticles. Specifically, HSPC phospholipids were mixed with different non-ionic surfactant molecules (Tween 80 and/or Span 80) for liposomal formulations, whereas both GMO and PHYT lipids were mixed with Span 80 and Tween 80 as alternative stabilizers, as well as with Poloxamer P407

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Zouliati, Konstantina, Christina Massala, Natassa Pippa, Nikolaos Naziris, Stergios Pispas, and Costas Demetzos. "Influence of Lipid’s Main Transition Temperature on the Stability of Chimeric Liposomal Systems." Current Nanomedicine 9, no. 2 (2019): 158–65. http://dx.doi.org/10.2174/2405461503666180912095425.

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Background: The incorporation of polymeric components into liposomes promotes structural rearrangement of the lipid bilayers that could affect their properties and their behavior. Therefore, by mixing phospholipids with polymeric compounds the, socalled chimeric liposomal nanosystems are produced and could be advantageous, compared with conventional (e.g. composed of pure phospholipids) liposomal nanostructures. Objective: In this work, we used lipids with different main transition temperature (Tm) i.e 1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC, Tm=55°C), L-α-phosphatidylcholine, hydroge

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13

Vlachou, Marilena, Natassa Pippa, Angeliki Siamidi, and Aimilia Kyrili. "Thermal analysis studies on the compatibility of furosemide with solid state and liquid crystalline excipients." Chemical Industry 74, no. 1 (2020): 15–23. http://dx.doi.org/10.2298/hemind190910002v.

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In the context of the present study, the thermal behavior of furosemide and the solid state excipients, sodium alginate, poly(ethylene oxide), poly(vinylpyrrolidone), lactose mono-hydrate and magnesium stearate, using Differential Scanning Calorimetry (DSC), was probed. It was found that the thermal behavior of these solid-state pharmaceutical excipients and furosemide correlates nicely with the literature relevant data. Regarding the furosemide-excipients mixtures, the DSC scans appear as a compilation of the thermal curves of each excipient. This suggests that the formulations containing the

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14

Kontara, E. K. M., I. S. Djunaidah, P. Coutteau, and P. Sorgeloos. "Comparison of native, lyso and hydrogenated soybean phosphatidylcholine as phospholipid source in the diet of postlarval penaeus japonicus bate." Archiv für Tierernaehrung 51, no. 1 (1998): 1–19. http://dx.doi.org/10.1080/17450399809381901.

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15

Zhang, Weinan, and Weitao Zhang. "Understanding the Effects of Cholesterol and Ethanol on the Stability and Morphology of Bicellar Mixtures." Highlights in Science, Engineering and Technology 30 (February 15, 2023): 185–95. http://dx.doi.org/10.54097/hset.v30i.4972.

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Elucidating the stability and morphology of bicellar mixtures is of great importance in the biomedical field. In this report, self-assembly cholesterol (CHOL)-containing bicellar mixtures were investigated, that were composed of long chain hydrogenated soybean phospholipids (HSPC), short chain 1, 2-diheptanoyl-sn-glycero-3-phosphocholine (DHPC) phospholipids, negatively charged dipalmitoyl phosphatidylglycerol (1, 2-dipalmitoyl-sn-glycero-3-phospho-(1'-rac-glycerol) (DPPG), and polyethylene glycol conjugated (1, 2-dimyristoyl-sn-glycero-3-phosphoethano-lamine-N-[methoxy (polyethylene glycol)-2

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16

Matsuo, Seira, Kenjirou Higashi, Kunikazu Moribe, et al. "Combination of Roll Grinding and High-Pressure Homogenization Can Prepare Stable Bicelles for Drug Delivery." Nanomaterials 8, no. 12 (2018): 998. http://dx.doi.org/10.3390/nano8120998.

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To improve the solubility of the drug nifedipine (NI), NI-encapsulated lipid-based nanoparticles (NI-LNs) have been prepared from neutral hydrogenated soybean phosphatidylcholine and negatively charged dipalmitoylphosphatidylglycerol at a molar ratio of 5/1 using by roll grinding and high-pressure homogenization. The NI-LNs exhibited high entrapment efficiency, long-term stability, and enhanced NI bioavailability. To better understand their structures, cryo transmission electron microscopy and atomic force microscopy were performed in the present study. Imaging from both instruments revealed t

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17

Forte, Jacopo, Patrizia Nadia Hanieh, Noemi Poerio та ін. "Mucoadhesive Rifampicin-Liposomes for the Treatment of Pulmonary Infection by Mycobacterium abscessus: Chitosan or ε-Poly-L-Lysine Decoration". Biomolecules 13, № 6 (2023): 924. http://dx.doi.org/10.3390/biom13060924.

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Mycobacterium abscessus (Mabs) is a dangerous non-tubercular mycobacterium responsible for severe pulmonary infections in immunologically vulnerable patients, due to its wide resistance to many different antibiotics which make its therapeutic management extremely difficult. Drug nanocarriers as liposomes may represent a promising delivery strategy against pulmonary Mabs infection, due to the possibility to be aerosolically administrated and to tune their properties in order to increase nebulization resistance and retainment of encapsulated drug. In fact, liposome surface can be modified by dec

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18

Tran, David T., Mark E. Hayes, Charles O. Noble, Zhipeng Dai, Peter K. Working, and Francis C. Szoka. "Twice Monthly Liposome Encapsulated Deferoxamine (LDFO) Has a High Molar Efficiency in Removing Total Body Iron in an Iron Dextran-Overloaded Mouse Model." Blood 128, no. 22 (2016): 2322. http://dx.doi.org/10.1182/blood.v128.22.2322.2322.

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Abstract Introduction: Patients who have β-thalassemia, sickle cell anemia, and myelodysplastic syndromes are sustained by long-term blood transfusion therapy. Transfusion therapy results in iron accumulation initially in the liver, spleen and bone marrow. These are the organs responsible for eliminating apoptotic red blood cells. To prevent iron overload, iron must be removed using iron chelators, administered either orally or infused on a daily basis. One strategy to more effectively deliver chelators to the sites of iron accumulation is to encapsulate them in liposomes. Liposomes also accum

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19

Tanka-Salamon, Anna, Attila Bóta, András Wacha, Judith Mihály, Miklós Lovas, and Krasimir Kolev. "Structure and Function of Trypsin-Loaded Fibrinolytic Liposomes." BioMed Research International 2017 (2017): 1–10. http://dx.doi.org/10.1155/2017/5130495.

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Protease encapsulation and its targeted release in thrombi may contribute to the reduction of haemorrhagic complications of thrombolysis. We aimed to prepare sterically stabilized trypsin-loaded liposomes (SSLT) and characterize their structure and fibrinolytic efficiency. Hydrogenated soybean phosphatidylcholine-basedSSLTwere prepared and their structure was studied by transmission electron microscopy combined with freeze fracture (FF-TEM), Fourier transform infrared spectroscopy (FT-IR), and small-angle X-ray scattering (SAXS). Fibrinolytic activity was examined at 45, 37, or 24°C on fibrin

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20

Lin, Weifeng, Zhang Liu, Nir Kampf, and Jacob Klein. "The Role of Hyaluronic Acid in Cartilage Boundary Lubrication." Cells 9, no. 7 (2020): 1606. http://dx.doi.org/10.3390/cells9071606.

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Hydration lubrication has emerged as a new paradigm for lubrication in aqueous and biological media, accounting especially for the extremely low friction (friction coefficients down to 0.001) of articular cartilage lubrication in joints. Among the ensemble of molecules acting in the joint, phosphatidylcholine (PC) lipids have been proposed as the key molecules forming, in a complex with other molecules including hyaluronic acid (HA), a robust layer on the outer surface of the cartilage. HA, ubiquitous in synovial joints, is not in itself a good boundary lubricant, but binds the PC lipids at th

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21

Khorami, Keyoomars, Sam Darestani Farahani, Anette Müllertz, and Thomas Rades. "Drug–Phospholipid Co-Amorphous Formulations: The Role of Preparation Methods and Phospholipid Selection." Pharmaceutics 16, no. 12 (2024): 1602. https://doi.org/10.3390/pharmaceutics16121602.

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Background/Objectives: This study aims to broaden the knowledge on co-amorphous phospholipid systems (CAPSs) by exploring the formation of CAPSs with a broader range of poorly water-soluble drugs, celecoxib (CCX), furosemide (FUR), nilotinib (NIL), and ritonavir (RIT), combined with amphiphilic phospholipids (PLs), including soybean phosphatidylcholine (SPC), hydrogenated phosphatidylcholine (HPC), and mono-acyl phosphatidylcholine (MAPC). Methods: The CAPSs were initially prepared at equimolar drug-to-phospholipid (PL) ratios by mechano-chemical activation-based, melt-based, and solvent-based

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22

Wang, Haoyu, Jian Song, and Yuhong Liu. "Superlubricity of Double‐Network Hydrogels Modified With Tween 80 and Hydrogenated Soybean Phosphatidylcholine." Biosurface and Biotribology 11, no. 1 (2025). https://doi.org/10.1049/bsb2.70008.

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ABSTRACTArtificial joint cartilage materials are central to arthroplasty for the treatment of osteoarthritis. Hydrogels are highly promising materials for fabricating artificial cartilage owing to their excellent biocompatibility and lubricity. Inspired by natural articular cartilage, in this study, we designed a modification strategy to enhance the lubricity of double‐network (DN) hydrogels. Specifically, two lubricating substances, nonionic surfactant Tween 80 and hydrogenated soybean phosphatidylcholine (HSPC), were incorporated into a DN hydrogel. Lubricity‐enhanced DN hydrogel exhibited s

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Miatmoko, Andang, Devy Maulidya Cahyani, Kumi Kawano, and Yoshiyuki Hattori. "Comparative Cellular and In Vivo Anti-cancer studies of Doxorubicin Liposomes Prepared with Different Types of Phospholipids." Indonesian Journal of Pharmacy, September 25, 2024. http://dx.doi.org/10.22146/ijp.9734.

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The selection of lipid components of membrane bilayer determines the rigidity of liposomes affecting drug efficacy, especially for cancer drug delivery. The present study evaluated liposomes with different rigidity for delivering doxorubicin (DOX). In this work, liposomes composed of rigid lipid, hydrogenated soybean phosphatidylcholine (HSPC), were totally or partially substituted with 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) or 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE). The liposomes are composed of phosphatidylcholine (HSPC, POPC), with and without combination with

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24

Kazemi Oskuee, Reza, Leila Gholami, Amir abbas Momtazi-Borojeni, et al. "Selective cellular uptake and cytotoxicity of curcumin-encapsulated SPC and HSPC liposome nanoparticles on human bladder cancer cells." Current Pharmaceutical Design 29 (March 31, 2023). http://dx.doi.org/10.2174/1381612829666230331084848.

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Background: Curcumin is a main bioactive constituent of turmeric (Curcuma longa L.) with pleiotropic health beneficial effects. However, poor bioavailability is the major barrier to the efficient pharmacological effects of curcumin in humans. Aims: The present study aimed to develop liposome formulations based on soybean phosphatidylcholine (SPC) and hydrogenated SPC (HSPC) to enhance the bioavailability of curcumin in bladder cancer cells. Methods: Curcumin was encapsulated in HSPC and SPC liposome nanoparticles using the solvent evaporation method. Physical properties, encapsulation efficien

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25

Momtazi-Borojeni, Amir Abbas, Elham Abdollahi, Mahmoud R. Jaafari, Maciej Banach, Gerald F. Watts, and Amirhossein Sahebkar. "Negatively-charged liposome nanoparticles can prevent dyslipidemia and atherosclerosis progression in the rabbit model." Current Vascular Pharmacology 19 (August 20, 2021). http://dx.doi.org/10.2174/1570161119666210820115150.

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Background and Aim: Negatively charged nanoliposomes have a strong attraction towards plasma lipoprotein particles and can thereby regulate lipid metabolism. Here, the impact of such nanoliposomes on dyslipidaemia and progression of atherosclerosis was investigated in a rabbit model. Methods: Two sets of negatively-charged nanoliposome formulations including [hydrogenated soy phosphatidylcholine (HSPC)/1,2-distearoyl-sn-glycero-3- phosphoglycerol (DSPG)] and [1,2-Dimyristoyl-sn-glycero-3-phosphorylcholine (DMPC)/1,2-Dimyristoyl-sn-glycero-3-phosphorylcholine (DMPG)/Cholesterol] were evaluated.

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26

Miatmoko, Andang, Ira Nurjannah, Nuril Fadilatul Nehru, et al. "Interactions of primaquine and chloroquine with PEGylated phosphatidylcholine liposomes." Scientific Reports 11, no. 1 (2021). http://dx.doi.org/10.1038/s41598-021-91866-0.

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AbstractThis study aimed to analyze the interaction of primaquine (PQ), chloroquine (CQ), and liposomes to support the design of optimal liposomal delivery for hepatic stage malaria infectious disease. The liposomes were composed of hydrogenated soybean phosphatidylcholine, cholesterol, and distearoyl-sn-glycero-3-phosphoethanolamine-N-(methoxy[polyethyleneglycol]-2000), prepared by thin film method, then evaluated for physicochemical and spectrospic characteristics. The calcein release was further evaluated to determine the effect of drug co-loading on liposomal membrane integrity. The result

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27

Rao, Pallavi, Madhavachary Rudrakshula, Rajendar Potham та ін. "Unified synthesis of DSPC and PSPC: Chemical entities of hydrogenated soy L-α-phosphatidylcholine (HSPC), a key component of liposomal drug formulations". Tetrahedron Letters, грудень 2024, 155424. https://doi.org/10.1016/j.tetlet.2024.155424.

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28

Momtazi-Borojeni, A. A., E. Abdollahi, M. R. Jaafari, M. Banach, and A. A. Sahebkar. "Protective effects of anionic nanoliposomes on hyperlipidemia and atherosclerosis progression in a rabbit model." European Heart Journal 41, Supplement_2 (2020). http://dx.doi.org/10.1093/ehjci/ehaa946.2995.

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Abstract Background and purpose Anionic nanoliposomes can regulate lipid metabolism by interacting with plasma lipoproteins. Here, we aimed to investigate the protective effects of anionic nanoliposomes against hyperlipidemia and atherosclerosis in the rabbit fed a high-fat diet (HFD) recapitulating human hyperlipidemia and atherosclerosis. Methods To prepare anionic nanoliposome formulations [containing hydrogenated soy phosphatidylcholine (HSPC) and 1,2-distearoyl-sn-glycero-3- phosphoglycerol (DSPG)] and [containing 1,2-Dimyristoyl-sn-glycero-3-phosphorylcholine (DMPC) and 1,2-Dimyristoyl-s

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29

Kolbina, Marina, Adrian Schulte, Peter van Hoogevest, Martin Körber, and Roland Bodmeier. "Evaluation of Hydrogenated Soybean Phosphatidylcholine Matrices Prepared by Hot Melt Extrusion for Oral Controlled Delivery of Water-Soluble Drugs." AAPS PharmSciTech 20, no. 4 (2019). http://dx.doi.org/10.1208/s12249-019-1366-3.

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30

Gupta, Twinkle, Priyanshu Nema, Sakshi Soni, et al. "Preparation and in vitro evaluation of BBG-250 loaded liposomal formulation for anticancer potential." Future Journal of Pharmaceutical Sciences 10, no. 1 (2024). http://dx.doi.org/10.1186/s43094-024-00581-w.

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Abstract Background Liposome-mediated drug delivery systems have emerged as a promising avenue for enhancing cancer treatment strategies. This study aims to develop and assess liposomal carriers loaded with Brilliant Blue G-250 (BBG-250), a potent P2X7 receptor antagonist that shows potential as an anti-tumor agent. Specifically, two types of liposomal formulations were designed: conventional liposomes composed of hydrogenated soya phosphatidylcholine (HSPC) and cholesterol, and pH-sensitive liposomes consisting of dioleoylphosphatidylethanolamine (DOPE), distearoylphosphatidylethanolamine-met

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31

Ryu, Hyeri, and Eun Seong Lee. "Artificial Liposomes With Internal Docking Site for Protein Delivery." Polymers for Advanced Technologies 36, no. 4 (2025). https://doi.org/10.1002/pat.70186.

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ABSTRACTIn this study, we developed a liposomal system incorporating two distinct pH‐responsive polymers to enhance the efficiency of protein delivery. Two pH‐responsive polymers were synthesized by conjugating deoxycholic acid (DOCA) and pH‐sensitive moieties [2,3‐dimethylmaleic anhydride (DMA) or 3‐(diethylamino)propylamine (DEAP)] to hyaluronic acid (HA), resulting in HA conjugates with DOCA and DMA (HDOC‐DMA) and with DOCA and DEAP (HDOC‐DEAP). Liposomes were fabricated using the thin‐film hydration technique with hydrogenated soy phosphatidylcholine (HSPC), HDOC‐DEAP, and HDOC‐DMA. Lysozy

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32

Bahrami, Azita, Alireza Farasat, Leila Zolghadr, Yalda Sabaghi, Farnaz PourFarzad, and Nematollah Gheibi. "The anticancer impacts of free and liposomal caffeic acid phenethyl ester (CAPE) on melanoma cell line (A375)." Cell Biochemistry and Function, December 18, 2023. http://dx.doi.org/10.1002/cbf.3900.

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AbstractThe deadliest type of skin cancer, malignant melanoma, is also the reason for the majority of skin cancer‐related deaths. The objective of this article was to investigate the efficiency of free caffeic acid phenethyl ester (CAPE) and liposomal CAPE in inducing apoptosis in melanoma cells (A375) in in vitro. CAPE was loaded into liposomes made up of hydrogenated soybean phosphatidylcholine, cholesterol, and 1,2‐distearoyl‐sn‐glycero‐3 phosphoethanolamine‐N‐[methoxy (polyethylene glycol)‐2000], and their physicochemical properties were assessed. (3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyl

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