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Journal articles on the topic 'Hydrophilic cellulose matrix'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Rama Rao, Tadikonda. "HYDROPHILIC MATRIX TABLETS AS ORAL CONTROLLED DRUG DELIVERY SYSTEMS IN 20TH CENTURY: A REVIEW." International Journal of Advanced Research 12, no. 08 (2024): 1372–93. http://dx.doi.org/10.21474/ijar01/19381.

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Matrix systems are easy to formulate compared to other controlled release dosage forms. The manufacture of matrix tablets involves the direct compression of blend of drug, retardant material and additives to form a tablet in which drug is embedded in a matrix core of the retardant. Alternatively, retardant-drug blends may be granulated prior to compression. Of the three classes of retardant material used to formulate matrix tablets, polymers that form hydrophilic matrices are attracting the attention of pharmaceutical technologists. These polymers include Methyl cellulose (MC), Hydroxy ethyl c

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2

Aravind, T., Mohd Shaikhul Ashraf, Rajesh A. S., et al. "Study of Progress on Nanocrystalline Cellulose and Natural Fiber Reinforcement Biocomposites." Journal of Nanomaterials 2022 (October 4, 2022): 1–16. http://dx.doi.org/10.1155/2022/6519480.

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Cellulosic biomass hydrolysis yields a nanoscale substance known as nanocrystalline cellulose (NCC). Gel, liquid, or powder is adaptable to a variety of uses. Nanocrystalline cellulose has unique renewability, biodegradability, and mechanical and physicochemical qualities, and abundance boosts the material’s mechanical strength by many orders of magnitude when introduced into the material matrix (polymer, ceramic, or metal). Nanocrystalline cellulose is not related with any serious environmental issues because it is a natural substance. The progress of this biomaterial as a green and renewable

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3

Bourlinos, Athanasios B., Ioannis Panagiotopoulos, Dimitrios Niarchos, and Dimitrios Petridis. "Hydrophilic Co–Pt Alloy Nanoparticles: Synthesis, Characterization, and Perspectives." Journal of Materials Research 19, no. 4 (2004): 1227–33. http://dx.doi.org/10.1557/jmr.2004.0159.

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Hydrophilic Co–Pt alloy nanoparticles nearing the equiatomic ratio and dispersedin water-soluble sodium carboxymethyl cellulose were synthesized by the aqueous reduction of CoCl2⋅6H2O and [Pt(NH3)4]Cl2⋅H2O with NaBH4 in presence of the cellulosic derivative. The as-received Co–Pt nanoparticles in the cellulosic matrix possess a disordered fcc structure that, upon calcination under an Ar atmosphereand carbonization of the cellulosic mantle of the particles, transformed to an ordered fcc phase. Both as-synthesized and calcined samples are magnetically soft at room temperature and exhibit a stron

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4

K., Rekha Rani* Y. Navya Reddy R. Mohana Priya. "FORMULATION AND EVALUATION OF SUSTAINED RELEASE DOSAGE FORM OF KETOPROFEN." indo American Journal of Pharmaceutical Sciences 04, no. 05 (2017): 1384–90. https://doi.org/10.5281/zenodo.804916.

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Sustained release Ketoprofen matrix tablets were prepared by direct compression method. The nature of the polymer influences the physical and release characteristics of the matrix tablet. The hydrophobic polymer, Ethyl cellulose has retarded the drug release from the tablet and the hydrophilic polymer, HPMC (15 cps) has release the drug. While making the combination of both hydrophilic and hydrophobic polymers i.e HPMC and Ethylcellulose with optimized ratio (F7) leads to sustained release of drug from matrix tablet for 12 hours was observed Key words: Ketoprofen, HPMC (15 cps), Ethyl cellulos

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5

Kenneth, Chinedu Ugoeze Nkemakolam Nwachukwu *. Favour Chiamaka Anumaka Goodness Nwovuhoma Ezioka. "STUDIES ON A HYDROPHILIC CELLULOSE MATRIX DERIVED FROM IPOMOEA BATATAS TUBERS I: PROCESSING AND PHYSICOCHEMICAL PROPERTIES." INDO AMERICAN JOURNAL OF PHARMACEUTICAL RESEARCH 07, no. 08 (2017): 638–45. https://doi.org/10.5281/zenodo.1036538.

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This work was designed to develop a hydrophilic cellulose matrix from the fibre contained in the tubers of Ipomoea batatas and to evaluate its excipient functionality. Starch was filtered from the slurry of milled tubers to obtain the fibre which was dried at 60 o C and pulverised. A 500 g of fibre was submerged in 3.50 % w/v of sodium hypochlorite and blended for 10 min. This was washed with distilled water to a neutral pH, then slurried in 96 % ethanol for 5 min, dried at 60 o C and reduced to 250 μm. The product was coded as I-hydrocel. Its organoleptic, pH, densities, flows, elemental cont

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6

Qu, Ping, Lu Bai, Yuan Gao, Guo Feng Wu, and Li Ping Zhang. "Compatibilizing Effects of Poly(ethylene Glycol) on PLA/Cellulose Nanowhiskers Composites." Materials Science Forum 675-677 (February 2011): 395–98. http://dx.doi.org/10.4028/www.scientific.net/msf.675-677.395.

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One best way to harness the petroleum-based solid wastes is to develop biodegradable materials. Among which, PLA is the most important one, because it is made from renewable plant. But Poly(lactic acid) (PLA) is brittle and low impact resistance. The cellulose nanowhiskers are about 5-40 nm in diameter and the length can be from 100 nm to several micrometers depending on the source of cellulose and the processing technology. The cellulose nanowhiskers can act as efficient reinforcement because of the high aspect ratios, important surface areas and high modulus. The celluloses nanowhiskers are

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7

Gaware, Ravi U., Gayatri R. Waykar, Madhuri K. Yewale, Rutuja B. Mhaske, and Poonam S. Mhaske. "Formulation and In-vitro evaluation of sustained release matrix tablet of Metformin hydrochloride." Journal of Drug Delivery and Therapeutics 9, no. 3 (2019): 95–98. http://dx.doi.org/10.22270/jddt.v9i3.2606.

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The low bioavailability and short half-life of Metformin hydrochloride (MH) make the development of sustained-release forms desirable. Present work involves preparation and optimization of sustained release matrix tablet of MH by direct compression method using HPMC K 100 and ethyl cellulose as a matrix forming polymer. Avicel was added as a direct compaction vehicle to improve the compaction behavior of Metformin which otherwise exhibits poor compaction behavior which again is further increased by its relatively high dose. Hydrophilic matrix of HPMC alone resulted in initial burst of Metformi

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8

M.Sreenivas, Varma* T.Mallika S.Spandana. "FORMULATION, DEVELOPMENT AND EVALUATION OF EXTENDED RELEASE MATRIX TABLETS OF GLIPIZIDE." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 05, no. 09 (2018): 9091–105. https://doi.org/10.5281/zenodo.1434252.

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Glipizide is used for treatment of type 2 diabetes mellitus. It is IInd generation sulfonylurea derivative. It is BCS class 2 drug and has a half life of 2-4 hours. The usual dosage is 2.5, 5 and 10 mg twice or thrice a day. To reduce the frequency of administration and to improve the patient compliance, a once daily extended release formulation of Glipizide is desirable. Hence selection of rate controlling excipient is necessary to achieve a constant in vivo input of drug. Hence in the present work an attempt has been made to develop extended release matrix tablets of Glipizide using hydrophi

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9

Qu, Ping, Yuan Gao, Guo-feng Wu, and Li-ping Zhang. "Nanocomposites of poly(lactic acid) reinforced with cellulose nanofibrils." BioResources 5, no. 3 (2010): 1811–23. http://dx.doi.org/10.15376/biores.5.3.1811-1823.

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A chemo-mechanical method was used to prepare cellulose nanofibrils dispersed uniformly in an organic solvent. Poly(ethylene glycol) (PEG 1000) was added to the matrix as a compatibilizer to improve the interfacial interaction between the hydrophobic poly(lactic acid) (PLA) and the hydrophilic cellulose nanofibrils. obtained by solvent casting methods from N,N-Dimethylacetamide (DMAc) were characterized by tensile testing machine, atomic force microscope (AFM), scanning electron microscope (SEM), and Fourier transform infrared spectroscopy (FT-IR). The tensile test results indicated that, by a

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10

Patel, Rupal, Viness Pillay, Yahya E. Choonara, and Thirumala Govender. "A Novel Cellulose-Based Hydrophilic Wafer Matrix for Rapid Bioactive Delivery." Journal of Bioactive and Compatible Polymers 22, no. 2 (2007): 119–42. http://dx.doi.org/10.1177/0883911506076045.

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11

Singh, Namrata, and Surya Prakash Gupta. "Formulation and Evaluation of Naringin Loaded Transdermal Patches using 32 Full Factorial Design." INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY 14, no. 02 (2024): 664–69. http://dx.doi.org/10.25258/ijddt.14.2.08.

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The main goal of the current study was to maximize the bioavailability of naringin by prolonging the drug’s release using transdermal patches. Ethyl cellulose (EC) served as the lipophilic component and hydroxy propyl methyl cellulose (HPMC) as the hydrophilic matrix in the preparation of transdermal patches. A 32-complete factorial technique was used to build the optimal design matrix, altering the ratio between the hydrophilic and lipophilic matrices. To create the best optimum formulation, three alternative ratios of EC and HPMC were employed. The patches had pH values ranging from 5.28 ± 0

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12

T N K, Suriyaprakash, S. Lakshmana Prabu, Arumugarajan A, and Sumathi A. "Formulation and Evaluation of Oral Controlled Release Clarithromycin Matrix Tablets using Hydrophilic Polymer." International Journal of Pharmaceutical Sciences and Nanotechnology 6, no. 4 (2013): 2255–59. http://dx.doi.org/10.37285/ijpsn.2013.6.4.8.

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The objective of the present study was to develop clarithromycin tablets from polymeric hydrophilic matrices using methocel and characterization for its physic-chemical properties and in vitro release studies to optimize its release profile with the standard marketed product. Matrix tablets were prepared by wet granulation method using PVP and ethyl cellulose as binding agents. The matrix tablets were evaluated for its thickness, hardness, friability, weight variation, drug content and in vitro release studies. The drug delivery was analyzed using the paddle method in phosphate buffer pH 6.0 (

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13

Khizer, Zara, Muhammad R. Akram, Rai M. Sarfraz, et al. "Plasticiser-Free 3D Printed Hydrophilic Matrices: Quantitative 3D Surface Texture, Mechanical, Swelling, Erosion, Drug Release and Pharmacokinetic Studies." Polymers 11, no. 7 (2019): 1095. http://dx.doi.org/10.3390/polym11071095.

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Hydroxypropyl methyl cellulose, HPMC, a hydrophilic polymer, is widely used for the development of extended release hydrophilic matrices and it is also considered as a good contender for the fabrication of 3D printing of matrix tablets. It is often combined with plasticisers to enable extrusion. The aim of the current project was to develop plasticizer-free 3D printed hydrophilic matrices using drug loaded filaments prepared via HME to achieve an in vitro (swelling, erosion and drug release) and in vivo (drug absorption) performance which is analogous to hydrophilic matrix tablets developed th

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14

Wei, Peng, Weiwei Chen, Qinghua Song, Yibing Wu, and Youjia Xu. "Superabsorbent hydrogels enhanced by quaternized tunicate cellulose nanocrystals with adjustable strength and swelling ratio." Cellulose 28, no. 6 (2021): 3723–32. http://dx.doi.org/10.1007/s10570-021-03776-z.

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AbstractSuperabsorbent hydrogels were prepared from biodegradable material, where the matrix was cross-linked cellulose and carboxymethyl cellulose and reinforced by quaternized tunicate cellulose nanocrystals (Q-TCNCs). Due to the large amount of hydrophilic groups on cellulose, carboxymethyl cellulose, and Q-TCNCs, the hydrogels had excellent water absorption capacity. The equilibrium swelling ratio of superabsorbent hydrogels exceeded 500 g/g in deionized water and exceeded 120 g/g even in synthetic urine, which was higher than those of commercial absorbent materials composed of copolymers

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15

Dhananjay, M. Patil* Abdullah S. Farooque Vinod A. Bairagi. "FORMULATION, DEVELOPMENT AND EVALUATION OF SUSTAINED RELEASE MATRIX TABLET OF METHIMAZOLE." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 05, no. 01 (2018): 209–25. https://doi.org/10.5281/zenodo.1145732.

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Sustained release tablets are generally taken once or twice a day during a course of treatment whereas in conventional dosage forms there is need to take 3-4 times dosage in a day to achieve the same therapeutic action. The drug was confirmed using FTIR, DSC and UV Spectroscopy, and tested for the stability of drug and polymer interactions. The tablet is formulated using carbopol, Ethyl cellulose and Eudragit, which makes it a matrix tablet, the carbopol is hydrophilic in nature and ramming two are hydrophobic in nature, which controls the release of drug. This formulation was tested for Mucoa

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16

Vueba, M. L., L. A. E. Batista de Carvalho, F. Veiga, J. J. Sousa, and M. E. Pina. "In vitrorelease of ketoprofen from hydrophilic matrix tablets containing cellulose polymer mixtures." Drug Development and Industrial Pharmacy 39, no. 11 (2012): 1651–62. http://dx.doi.org/10.3109/03639045.2012.729146.

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17

Vueba, M. L., L. A. E. Batista de Carvalho, F. Veiga, J. J. Sousa, and M. E. Pina. "Influence of cellulose ether polymers on ketoprofen release from hydrophilic matrix tablets." European Journal of Pharmaceutics and Biopharmaceutics 58, no. 1 (2004): 51–59. http://dx.doi.org/10.1016/j.ejpb.2004.03.006.

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18

Rojas, John, Cesar González, Carolina Rico, and Oswaldo Saez. "Formulation of a modified release metformin. HCl matrix tablet: influence of some hydrophilic polymers on release rate and in-vitro evaluation." Brazilian Journal of Pharmaceutical Sciences 47, no. 3 (2011): 483–93. http://dx.doi.org/10.1590/s1984-82502011000300006.

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Metformin hydrochloride is an antidiabetic agent which improves glucose tolerance in patients with type 2 diabetes and reduces basal plasma levels of glucose. In this study, a simplex centroid experimental design with 69 runs was used to select the best combination of some hydrophilic polymers that rendered a 24 h in-vitro release profile of metformin.HCl. The Korsmeyer-Peppas model was used to model the dissolution profiles since it presented the best fit to the experimental data. Further, a cubic model predicted the best formulation of metformin.HCl containing polyvinyl pyrrolidone, ethyl ce

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19

Li, Nancy, Jackie Zheng, Pejman Hadi, et al. "Synthesis and Characterization of a High Flux Nanocellulose–Cellulose Acetate Nanocomposite Membrane." Membranes 9, no. 6 (2019): 70. http://dx.doi.org/10.3390/membranes9060070.

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Despite the advantages of membrane processes, their high energy requirement remains a major challenge. Fabrication of nanocomposite membranes by incorporating various nanomaterials in the polymer matrix has shown promise for enhancing membrane flux. In this study, we embed functionalized cellulose nanofibers (CNFs) with high aspect ratios in the polymer matrix to create hydrophilic nanochannels that reduce membrane resistance and facilitate the facile transport of water molecules through the membrane. The results showed that the incorporation of 0.1 wt % CNF into the polymer matrix did not cha

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20

Verma, Amit Kumar, Arun Kumar, Subbiah Ramasamy, Ajit Kumar Yadav, and Rohit Kumar Bijauliya. "Evaluation of Drug Release from Carboxymethyl Starch-Xanthan Gum-HPMC Matrix." Journal of Drug Delivery and Therapeutics 11, no. 5 (2021): 27–32. http://dx.doi.org/10.22270/jddt.v11i5.5000.

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The use of hydrophilic polymers from natural origin. Especially the polysaccharides have been the focus of current research activity in the design of matrix device due to their non toxic, biocompatible, biodegradable nature and broad regulatory acceptance. A large number of polysaccharides such as Carboxymethyl starch, Xanthan gum, Hydroxy propyl methyl cellulose (HPMC), Sodium Alginate etc, have been used as hydrophilic matrices to investigate release behavior of drug. In order to enrich the resources, there is a quest for new polysaccharide owing to their diverse chemical composition and fun

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21

Pang, C., R. Shanks, K. Ing, and F. Daver. "Plasticised cellulose acetate-natural fibre composite." World Journal of Engineering 10, no. 5 (2013): 405–10. http://dx.doi.org/10.1260/1708-5284.10.5.405.

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Due to positive impact on the environment, biodegradable composite materials are of growing interest. This study used cellulose acetate, a derivative of cellulose, as the matrix for its solubility and flexibility. Kenaf composites have been used in furniture, ceiling panels, and fences. The aim is to prepare composites with plasticized cellulose acetate and natural fibre. The kenaf fibres were surface treated to remove impurities, in particular, hemicellulose, wax, and lignin. Chopped kenaf was added to dissolve cellulose acetate and cast on a Petri dish. After solvent has evaporated, the comp

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22

Siddiqui, Mehak, L. K. Omray, and Pushpendra Soni. "Formulation of Metformin Sustained Release Tablet Using Natural Polymer." Journal of Drug Delivery and Therapeutics 11, no. 2 (2021): 31–37. http://dx.doi.org/10.22270/jddt.v11i2.4579.

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The overall objective of the present work was to develop an oral sustained-release (SR) Metformin tablet that is prepared by the direct compression method by using hydrophilic hydroxyl propyl methyl cellulose (HPMC) and Guar gum polymer alone as well as in combination at different concentrations. Metformin is a biguanide that has a relatively short plasma half-life. It has low absolute bioavailability. All the properties were evaluated for thickness, weight variation, hardness and drug content uniformity and in vitro drug release. The mean dissolution time is used to characterize the drug rele

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23

Rahman, B. M., M. A. Islam, M. I. I. Wahed, et al. "In-vitro Studies of Pentoxifylline Controlled-Release from Hydrophilic Matrices." Journal of Scientific Research 1, no. 2 (2009): 353–62. http://dx.doi.org/10.3329/jsr.v1i2.1080.

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Methocel K15 MCR (a modified hydroxypropylmethylcellulose) matrix tablets of pentoxifylline using microcrystalline cellulose (MCC), starch and lactose were prepared by wet granulation process. There was no significant difference in drug release between the hydrophilic matrices when the Methocel K15 MCR concentration was modified in low percentage. The release of pentoxifylline was influenced by the presence of microcrystalline cellulose, and by the different concentrations of starch and lactose. The data obtained proved that the formulation with 12.5% Methocel K15 MCR and 20% lactose is more u

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24

Amior, Aicha, Hamid Satha, Alessandra Vitale, Roberta Bongiovanni, and Sara Dalle Vacche. "Photocured Composite Films with Microfibrillated Cellulose: A Study of Water Vapor Permeability." Coatings 13, no. 2 (2023): 297. http://dx.doi.org/10.3390/coatings13020297.

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Photocuring is a crosslinking process, widely employed to produce polymers in the form of film. As it is an environmentally friendly process, it is particularly interesting for the preparation of sustainable materials and composites. In this work, composite self-standing films were obtained combining microfibrillated cellulose (MFC) and photocured matrices. To understand the influence of the polarity and surface tension of the matrix on the properties of the composite, poly(ethylene glycol) diacrylate was selected as a hydrophilic matrix and soybean oil epoxidized acrylate as a hydrophobic mat

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Leluk, Karol, Stanisław Frąckowiak, Joanna Ludwiczak, Tomasz Rydzkowski, and Vijay Kumar Thakur. "The Impact of Filler Geometry on Polylactic Acid-Based Sustainable Polymer Composites." Molecules 26, no. 1 (2020): 149. http://dx.doi.org/10.3390/molecules26010149.

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Recently, biocomposites have emerged as materials of great interest to the scientists and industry around the globe. Among various polymers, polylactic acid (PLA) is a popular matrix material with high potential for advanced applications. Various particulate materials and nanoparticles have been used as the filler in PLA based matrix. One of the extensively studied filler is cellulose. However, cellulose fibres, due to their hydrophilic nature, are difficult to blend with a hydrophobic polymer matrix. This leads to agglomeration and creates voids, reducing the mechanical strength of the result

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26

Klančar, Uroš, Matej Horvat, and Saša Baumgartner. "Correlating Cellulose Derivative Intrinsic Viscosity with Mechanical Susceptibility of Swollen Hydrophilic Matrix Tablets." AAPS PharmSciTech 13, no. 3 (2012): 903–10. http://dx.doi.org/10.1208/s12249-012-9811-6.

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27

PANOMSUK, Suwannee P., Tomomi HATANAKA, Tetsuya AIBA, Kazunori KATAYAMA, and Tamotsu KOIZUMI. "A Study of the Hydrophilic Cellulose Matrix: Effect of Drugs on Swelling Properties." CHEMICAL & PHARMACEUTICAL BULLETIN 44, no. 5 (1996): 1039–42. http://dx.doi.org/10.1248/cpb.44.1039.

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28

Sunil, Firangi* Ananth Rao Kulkarni R. B. Sangoligi Dr. S. N. Hiremath Dr Syed Sanaullah. "Formulation and In-vitro Evaluation of Controlled Release Matrix Tablets of Anti-Hypertensive Drug: Verapamil Hydrochloride." International Journal in Pharmaceutical Sciences 1, no. 10 (2023): 1–12. https://doi.org/10.5281/zenodo.8396256.

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The aim of the present study was to develop model controlled release (CR) matrix tablet formulations for Verapamil hydrochloride and to study the influence of hydroxy propyl methyl cellulose (HPMC) ratio on drug release and also to assess the potential value of HPMC mixtures as gelling agents in matrix tablets. The release of verapamil hydrochloride CR matrix tablets based on hydrophilic matrices of hydroxy propyl methyl cellulose of different viscosity grades of HPMC 50cps, HPMC K4M and HPMC K100M was studied. The compressed matrix tablets were evaluated for various parameters like hardness,

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29

WANG, JUNPING, YIZHOU ZHU, and JIAN DU. "BACTERIAL CELLULOSE: A NATURAL NANOMATERIAL FOR BIOMEDICAL APPLICATIONS." Journal of Mechanics in Medicine and Biology 11, no. 02 (2011): 285–306. http://dx.doi.org/10.1142/s0219519411004058.

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Bacterial cellulose (BC) synthesized from Acetobacter xylinum has drawn lots of attention and interest from biomedical device field due to its unique structure and properties. Characterized by its remarkable physical strength and extremely hydrophilic surface, BC has become a favorable material for wound healing, neuron protection, and vascular grafts. Moreover, due to its homologous structure with native extracellular matrix, BC nanofibrous matrix could also be a potent candidate for tissue-engineered scaffolding materials. In this review, the characters and properties of BC, as a promising m

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Dr., K. Vinod Kumar*, Rama Devi B., Siva Sai B., Sai Anil Kumar Dora B., Yeshwanth G., and Ashik Sk. "FORMULATION AND EVALUATION OF TOLTERODINE EXTENDED RELEASE TABLETS." World Journal of Pharmaceutical Science and Research 3, no. 3 (2024): 312–24. https://doi.org/10.5281/zenodo.12732638.

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The objective of this study was to develop and evaluate Tolterodine Extended Release matrix tablet by using various grades and ratios of hydroxy propyl methyl cellulose (HPMC), Xanthan gum, Ethyl cellulose as rate controlling hydrophilic polymers and bioequivalent testing with the innovator Detrol. The drug was compatible with the formulation components. Hence Lactose Anhydrous, Di calcium Phosphate (DC grade), Xanthan gum, Ethyl cellulose, HPMCK4M, HPMCK100M, Opadry orange were selected as excipients for the lab scale development. Blends were evaluated for various parameters such as bulk dens

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Nissilä, Tuukka, Jiayuan Wei, Shiyu Geng, Anita Teleman, and Kristiina Oksman. "Ice-Templated Cellulose Nanofiber Filaments as a Reinforcement Material in Epoxy Composites." Nanomaterials 11, no. 2 (2021): 490. http://dx.doi.org/10.3390/nano11020490.

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Finding renewable alternatives to the commonly used reinforcement materials in composites is attracting a significant amount of research interest. Nanocellulose is a promising candidate owing to its wide availability and favorable properties such as high Young’s modulus. This study addressed the major problems inherent to cellulose nanocomposites, namely, controlling the fiber structure and obtaining a sufficient interfacial adhesion between nanocellulose and a non-hydrophilic matrix. Unidirectionally aligned cellulose nanofiber filament mats were obtained via ice-templating, and chemical vapo

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32

Heyam, Saad Ali, Saad Rasha, M. A. Elhaj Babiker, Khan Jiyauddin, Kaleemullah Mohammed, and Al-Dhalli Samer. "Effect of Different Parameters on the Release of Diclofenac Modified Tablets." International Journal of Current Pharmaceutical Review and Research 8, no. 2 (2017): 192–97. https://doi.org/10.5281/zenodo.12677968.

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In the present study the influence of designing and development of sustained release (SR) matrix tablets of diclofenacsodium were investigated. The aim was to increase therapeutic efficacy, reduce frequency of administration, and improvepatient compliance. Sustained release matrix tablets of diclofenac sodium, were developed by using different drug: gumratios, using Xanthan gum as matrix former, microcrystalline cellulose as diluent and Polyethylene Glycol (PEG 6000) asrelease modifier. Formulated tablets were evaluated for friability, hardness, thickness and their relation to the amount ofgum

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Aziz, Fatin Akilah, and Mokhtar Mat Salleh. "<i>In Sit</i>u Surface Treatment on All-Cellulose Composites (ACCs) Using Alkyl Ketene Dimer (AKD) via Solvent Infusion Processing (SIP)." Materials Science Forum 1077 (December 15, 2022): 3–9. http://dx.doi.org/10.4028/p-m00p6g.

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Water repellence all-cellulose composite (ACC) was developed using alkyl ketene dimer (AKD). ACC is a novel single polymer composite (SPC), consisting of cellulose for both reinforcing and matrix phases. However, a technical challenge was observed for ACCs due to hydrophilic characteristic of cellulose, contributing to a higher water absorption, instability and deterioration of its physical and mechanical properties. In this study, ACC was prepared using solvent infusion process (SIP) and AKD treatment was performed in-situ during SIP prior to the drying process. As the results, ACC changed fr

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34

Milotskyi, Romain, Ryo Serizawa, Kaoru Yanagisawa, et al. "Composite of Cellulose-Nanofiber-Reinforced Cellulose Acetate Butyrate: Improvement of Mechanical Strength by Cross-Linking of Hydroxyl Groups." Journal of Composites Science 7, no. 3 (2023): 130. http://dx.doi.org/10.3390/jcs7030130.

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A great challenge hindering the use of cellulose nanofibers (CNF) as a reinforcing filler in bio-based polymeric matrices are their poor chemical compatibility. This is because of the inherent hydrophilic nature of CNF and the hydrophobic nature of the polymeric matrix. In this study, cellulose laminates were prepared by using CNF as a filler and cellulose acetate butyrate (CAB) as the polymer matrix. To improve the compatibility between CAB and CNF, the residual hydroxyl groups of CAB and the hydroxyl groups on the surface of CNF were cross-linked with bio-derived polyisocyanurate D376N (STAB

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Fernando, Sarah, Chamila Gunasekara, Amin Shahpasandi, et al. "Sustainable Cement Composite Integrating Waste Cellulose Fibre: A Comprehensive Review." Polymers 15, no. 3 (2023): 520. http://dx.doi.org/10.3390/polym15030520.

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This review presents the research conducted to date in the field of cement-based composites reinforced with waste paper-based cellulose fibres, focusing on their composition, mechanical properties, and durability characteristics. The literature demonstrates that the properties of raw material (depending on their own chemical composition) significantly influence the formation of the cement composite binders. When considering fresh properties, the presence of silica and magnesium compounds generally lead to favourable effects on the setting of the cement composite when combined with waste paper

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Spiers, Andrew J., and Paul B. Rainey. "The Pseudomonas fluorescens SBW25 wrinkly spreader biofilm requires attachment factor, cellulose fibre and LPS interactions to maintain strength and integrity." Microbiology 151, no. 9 (2005): 2829–39. http://dx.doi.org/10.1099/mic.0.27984-0.

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The wrinkly spreader (WS) isolate of Pseudomonas fluorescens SBW25 forms a substantial biofilm at the air–liquid interface. The biofilm is composed of an extracellular partially acetylated cellulose-fibre matrix, and previous mutagenesis of WS with mini-Tn5 had identified both the regulatory and cellulose-biosynthetic operons. One uncharacterized WS mutant, WS-5, still expressed cellulose but produced very weak biofilms. In this work, the mini-Tn5 insertion site in WS-5 has been identified as being immediately upstream of the tol-pal operon. Like Tol-Pal mutants of other Gram-negative bacteria

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Granda, Luis Angel, Helena Oliver-Ortega, Maria José Fabra, et al. "Improved Process to Obtain Nanofibrillated Cellulose (CNF) Reinforced Starch Films with Upgraded Mechanical Properties and Barrier Character." Polymers 12, no. 5 (2020): 1071. http://dx.doi.org/10.3390/polym12051071.

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Nowadays, the interest on nanofibrillated cellulose (CNF) has increased owing to its sustainability and its capacity to improve mechanical and barrier properties of polymeric films. Moreover, this filler shows some drawbacks related with its high capacity to form aggregates, hindering its dispersion in the matrix. In this work, an improved procedure to optimize the dispersability of CNF in a thermoplastic starch was put forward. On the one hand, CNF needs a hydrophilic dispersant to be included in the matrix, and on the other, starch needs a hydrophilic plasticizer to obtain a thermoformable m

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Shi, Shih-Chen, Tao-Hsing Chen, and Pramod Kumar Mandal. "Enhancing the Mechanical and Tribological Properties of Cellulose Nanocomposites with Aluminum Nanoadditives." Polymers 12, no. 6 (2020): 1246. http://dx.doi.org/10.3390/polym12061246.

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Hydroxypropyl methylcellulose (HPMC) is a common hydrophilic and biodegradable polymer that can form films. This study incorporated aluminum nanoadditives as an enhancement reagent into a HPMC matrix. Mechanical properties of nanocompoistes, including the tensile strength and the elastic modulus, were analyzed with a nano-tensile tester. The incorporation of additives in HPMC films significantly enhances their mechanical and film barrier properties. Evidence of bonding between the additive and matrix was observed by Fourier-transform infrared spectrometer analysis. The additives occupy the spa

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Modi, Vaibhav, and Antti J. Karttunen. "Molecular Dynamics Simulations on the Elastic Properties of Polypropylene Bionanocomposite Reinforced with Cellulose Nanofibrils." Nanomaterials 12, no. 19 (2022): 3379. http://dx.doi.org/10.3390/nano12193379.

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Cellulose-reinforced polypropylene bionanocomposites can show improved elastic properties over their pure polypropylene counterparts. We have used equilibrium and non-equilibrium molecular dynamics (MD) simulations to study the elastic properties of polypropylene bionanocomposite systems composed of cellulose nanofibrils (CNF), polypropylene (PP) matrix, and maleic anhydride (MAH) coupling agent. The components of the bionanocomposite were parametrized for compatibility with the AMBER14SB force fields. The elastic properties of pure PP systems converge for the chains with at least 20 monomers.

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Kusmono, Kusmono, and Hasn Risda Azizah. "Pengembangan Acetylated Cellulose Nanofibers dari Microcrystalline Cellulose: Studi Perubahan Gugus Fungsi dan Indeks Kristalinitas melalui Asetilasi dan Nanofibrilasi." Journal of Mechanical Engineering 1, no. 1 (2024): 67–75. http://dx.doi.org/10.47134/jme.v1i1.2192.

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Cellulose nanofiber (CNF) has promising potential as a reinforcement in polymer matrix nanocomposites. CNF is polar or hydrophilic due to having many hydroxyl groups. When CNF particles are combined with a non-polar polymer matrix, the CNF is difficult to distribute evenly and tends to agglomerate due to differences in polarity so that the strengthening effect of CNF is limited. To overcome this problem, it is necessary to chemically modify the CNF surface. Acetylation is one of the most widely used CNF surface modification methods to increase the compatibility between a non-polar polymer matr

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Sheferov, Ilya Alexandrovich, Anastasia Anatol`evna Emasheva, Alyona Anatol`evna Sheferova, et al. "Study of xymedone release from hydrogels with zinc oxide nanoparticles." Journal of Drug Delivery and Therapeutics 14, no. 8 (2024): 43–48. http://dx.doi.org/10.22270/jddt.v14i8.6728.

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In this work the approaches to assess of the xymedone release from hydrophilic gels with zinc oxide nanoparticles were proposed using a vertical Franz diffusion cell at 37 ℃. A partial validation protocol included the varying of the membrane polarity (lipophilic or hydrophilic cellulose acetate), the acceptor chamber volume (4,35 mL or 12,71 mL), the gel composition (with or without zinc oxide nanoparticles), as well as the metrological characteristics for the xymedone assay when it was released through the membrane in a Franz cell. It was estimated that the Franz cell with the volume of 12,71

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Bochare, Umesh J* Shelke Satish P. Ambore Sandeep M. Jain Shirish P. Ghodke Amol D. "FORMULATION AND EVALUATION OF SUSTAINED RELEASE MATRIX TABLET OF GLIPIZIDE BY USING COMBINATION OF NATURAL AND SYNTHETIC POLYMER." Journal of Pharma Research 7, no. 7 (2018): 136–43. https://doi.org/10.5281/zenodo.1311809.

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<strong><em>ABSTRACT</em></strong> <strong><em>C</em></strong><em>ontrolled release delivery system provides a uniform concentration or amount of the drug at the absorption site and thus, after absorption allow maintenance of plasma concentrations within a therapeutic range, which minimizes side effects and also reduces the frequency of administration. </em><em>The overall objective of this work was to develop a tablet glipizide oral sustained release prepared by the method of direct compression, using hydroxy propyl methyl cellulose (HPMC K-100M) and xanthan gum polymer alone and in combinati

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43

Bochare, Umesh J. *. Shelke Satish P. Ambore Sandeep M. Jain Shirish P. Ghodke Amol D. "FORMULATION AND EVALUATION OF SUSTAINED RELEASE MATRIX TABLET OF GLIPIZIDE BY USING COMBINATION OF NATURAL AND SYNTHETIC POLYMER." Journal of Pharma Research 7, no. 7 (2018): 136–42. https://doi.org/10.5281/zenodo.1311813.

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<strong><em>ABSTRACT</em></strong> <strong><em>C</em></strong><em>ontrolled release delivery system provides a uniform concentration or amount of the drug at the absorption site and thus, after absorption allow maintenance of plasma concentrations within a therapeutic range, which minimizes side effects and also reduces the frequency of administration. </em><em>The overall objective of this work was to develop a tablet glipizide oral sustained release prepared by the method of direct compression, using hydroxy propyl methyl cellulose (HPMC K-100M) and xanthan gum polymer alone and in combinati

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44

Bochare, Umesh J. *. Shelke Satish P. Ambore Sandeep M. Jain Shirish P. Ghodke Amol D. "FORMULATION AND EVALUATION OF SUSTAINED RELEASE MATRIX TABLET OF GLIPIZIDE BY USING COMBINATION OF NATURAL AND SYNTHETIC POLYMER." Journal of Pharma Research 7, no. 7 (2018): 136–42. https://doi.org/10.5281/zenodo.1311817.

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<strong><em>ABSTRACT</em></strong> <strong><em>C</em></strong><em>ontrolled release delivery system provides a uniform concentration or amount of the drug at the absorption site and thus, after absorption allow maintenance of plasma concentrations within a therapeutic range, which minimizes side effects and also reduces the frequency of administration. </em><em>The overall objective of this work was to develop a tablet glipizide oral sustained release prepared by the method of direct compression, using hydroxy propyl methyl cellulose (HPMC K-100M) and xanthan gum polymer alone and in combinati

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45

Bochare, Umesh J. *. Shelke Satish P. Ambore Sandeep M. Jain Shirish P. Ghodke Amol D. "FORMULATION AND EVALUATION OF SUSTAINED RELEASE MATRIX TABLET OF GLIPIZIDE BY USING COMBINATION OF NATURAL AND SYNTHETIC POLYMER." Journal of Pharma Research 7, no. 7 (2018): 136–42. https://doi.org/10.5281/zenodo.1311823.

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<strong><em>ABSTRACT</em></strong> <strong><em>C</em></strong><em>ontrolled release delivery system provides a uniform concentration or amount of the drug at the absorption site and thus, after absorption allow maintenance of plasma concentrations within a therapeutic range, which minimizes side effects and also reduces the frequency of administration. </em><em>The overall objective of this work was to develop a tablet glipizide oral sustained release prepared by the method of direct compression, using hydroxy propyl methyl cellulose (HPMC K-100M) and xanthan gum polymer alone and in combinati

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Oishi, Yukako, and Atsushi Hotta. "The Structure and the Mechanical Properties of a Newly Fabricated Cellulose-Nanofiber/Polyvinyl-Alcohol Composite." MRS Proceedings 1621 (2014): 149–54. http://dx.doi.org/10.1557/opl.2014.141.

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ABSTRACTCellulose nanofibers (Cel-F) were extracted by a simple and harmless Star Burst (SB) method, which produced aqueous cellulose-nanofiber solution just by running original cellulose beads under a high pressure of water in the synthetic SB chamber. By optimizing the SB process conditions, the cellulose nanofibers with high aspect ratios and the small diameter of ∼23 nm were obtained, which was confirmed by transmission electron microscopy (TEM). From the structural analysis of the Cel-F/PVA composite by the scanning electron microscopy (SEM), it was found that the Cel-F were homogeneously

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Li, Lei, Minjian Cao, Jingdan Li, Cong Wang, and Shengjuan Li. "Structure Optimization of Cellulose Nanofibers/Poly(Lactic Acid) Composites by the Sizing of AKD." Polymers 13, no. 23 (2021): 4119. http://dx.doi.org/10.3390/polym13234119.

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Recently, cellulose nanofibers (CNF) are used as one novel fillers to reinforce poly(lactic acid) (PLA) matrix and form PLA green nanocomposites. In the present work, alkyl ketene dimer (AKD) was used as the sizing of CNF to improve the interfacial compatibility between the hydrophilic CNF and the hydrophobic PLA. The interactions between the AKD and CNF were characterized by X-ray diffraction (XRD) and Fourier transform infrared spectroscopy (FTIR), which showed the formation of ketone ester structure between AKD and the hydroxyl groups of CNF. Thermo gravimetric analysis (TGA) showed the lit

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48

LU, YUAN, HALIL LEVENT TEKINALP, CLAUDE CLIFFORD EBERLE, WILLIAM PETER, AMIT KUMAR NASKAR, and SOYDAN OZCAN. "Nanocellulose in polymer composites and biomedical applications." June 2014 13, no. 6 (2014): 47–54. http://dx.doi.org/10.32964/tj13.6.47.

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Nanocellulose materials are nano-sized cellulose fibrils or crystals produced by bacteria or derived from plants. These materials exhibit exceptional strength characteristics, light weight, transparency, and excellent biocompatibility. Compared with some other nanomaterials, nanocellulose is renewable and less expensive to produce, and a wide range of applications for nanocellulose has been envisioned. The areas most extensively studied include polymer composites and biomedical applications. Cellulose nanofibrils and nanocrystals have been used to reinforce both thermoplastic and thermoset pol

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Chauhan, Shikha Baghel, Tanveer Naved, and Nayyar Parvez. "EFFECT OF HYDROPHILIC AND HYDROPHOBIC POLYMER MATRIX ON THE TRANSDERMAL DRUG DELIVERY OF ETHINYLESTRADIOL AND MEDROXYPROGESTERONE ACETATE." International Journal of Applied Pharmaceutics 11, no. 1 (2019): 210. http://dx.doi.org/10.22159/ijap.2019v11i1.29886.

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Objective: The aims of the present study were to develop different matrix patches with various ratios of hydrophilic and hydrophobic polymer combinations such as ethyl cellulose (EC) and polyvinylpyrrolidone (PVP) and eudragit RL 100 (ERL) and eudragit RS 100 (ERS) containing ethinylestradiol and medroxyprogesterone acetate and to perform physicochemical characterization and in vitro permeation studies through rat skin.Methods: Six formulations (F1 to F6) were developed by varying the concentration of both hydrophilic and hydrophobic polymer and keeping the drug load constant. Physical paramet

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50

Venkatesh, D. Nagasamy, Jawahar N., Ganesh G.N.K., et al. "Development and In vitro Evaluation of Sustained Release Matrix Tablets of Theophylline using Hydrophilic Polymer as Release Retardant." International Journal of Pharmaceutical Sciences and Nanotechnology 2, no. 1 (2009): 450–56. http://dx.doi.org/10.37285/ijpsn.2009.2.1.9.

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In the present investigation, an attempt has been made to increase therapeutic efficacy, reduce frequency of administration and improve patient compliance by developing sustained release matrix tablets of theophylline. Sustained release matrix tablets of theophylline were developed by using drug and different concentrations of polymer such as 10, 20, 30, 40 and 50%. Hydroxypropylmethylcellulose (HPMC) was used as a matrix material and microcrystalline cellulose as diluent. All the lubricated formulations were compressed using 10 mm flat faced punches. Compressed tablets were evaluated for unif

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