Relevant bibliographies by topics / Hydrophilic Interaction Liquid Chromatoghraphy (HILIC)

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  2. Dissertations / Theses
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Academic literature on the topic 'Hydrophilic Interaction Liquid Chromatoghraphy (HILIC)'

Author: Grafiati
Published: 20 February 2023
Last updated: 31 July 2025

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Journal articles on the topic "Hydrophilic Interaction Liquid Chromatoghraphy (HILIC)"

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Ajay, A.* Prasanth S. S. Sanooja P. k. Jisha U. K. T. Akshara Riya Rajan Sibina M. K. Mohammed Farooq P. "Hydrophilic Interaction Liquid Chromatography (Hilic)." International Journal of Pharmaceutical Sciences 2, no. 8 (2024): 2816–21. https://doi.org/10.5281/zenodo.13292739.

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Hydrophilic interaction liquid chromatography or HILIC is a powerful analytical technique for the separation and analysis of polar and hydrophilic compounds, including small molecules, peptides, and proteins. HILIC is a variation of normal phase chromatography. It is also called as “Reverse reversed-phase” or “Aqueous normal-phase” chromatography. This chromatographic method capitalizes on the unique interactions between analytes and a polar stationary phase, which enhances the retention of hydrophilic compounds through mechanisms such as partitioning, hydrogen bonding
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Boersema, Paul J., Shabaz Mohammed, and Albert J. R. Heck. "Hydrophilic interaction liquid chromatography (HILIC) in proteomics." Analytical and Bioanalytical Chemistry 391, no. 1 (2008): 151–59. http://dx.doi.org/10.1007/s00216-008-1865-7.

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Noga, Sylwia, Attila Felinger, and Bogusław Buszewski. "Hydrophilic Interaction Liquid Chromatography and Per Aqueous Liquid Chromatography in Fungicides Analysis." Journal of AOAC INTERNATIONAL 95, no. 5 (2012): 1362–70. http://dx.doi.org/10.5740/jaoacint.sge_noga.

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Abstract The goal of the study was to investigate the retention mechanism of selected fungicides in hydrophilic interaction liquid chromatography (HILIC) and per aqueous liquid chromatography (PALC). Chromatographic measurements were made on four physicochemically diversified HILIC columns, which were evaluated for the analysis of nine biologically active compounds, such as strobilurins and triazoles. The effects of the operating conditions on separations were investigated, including the concentration of the organic solvent in the aqueous-organic (acetonitrile) mobile phase. The results were c
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Radoičić, Aleksandra, Sandra Šegan, Aleksandra Dramićanin, and Dušanka Milojković-Opsenica. "Hydrophilic Interaction Liquid Chromatography for the Analysis of Pharmaceutical Formulations." Current Analytical Chemistry 20, no. 5 (2024): 295–317. http://dx.doi.org/10.2174/0115734110290557240305045032.

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Abstract: For a long time, Reversed-Phase Liquid Chromatography (RPLC) was the most dominant technique for the analysis of pharmaceutical compounds, but with poor efficiency in the separation of small polar molecules. From the efforts to solve the problem of insufficient retention of these molecules, during the last decades, a mode of liquid chromatography named Hydrophilic Interaction Liquid Chromatography (HILIC) has experienced vast expansion. It is based on the use of a highly hydrophilic stationary phase along with an aqueous mobile phase with high organic modifier content. In this review
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Skoczylas, Magdalena, Szymon Bocian, and Bogusław Buszewski. "Dipeptide-bonded stationary phases for hydrophilic interaction liquid chromatography." RSC Advances 6, no. 98 (2016): 96389–97. http://dx.doi.org/10.1039/c6ra17704b.

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Wang, Meng, Ryoichi Hiraki, Norihiro Nakamura, et al. "Determination of Gemcitabine in Plasma of Bladder Cancer Patients by Hydrophilic Interaction Chromatography with Ultraviolet Detection." Journal of Chromatographic Science 58, no. 7 (2020): 587–90. http://dx.doi.org/10.1093/chromsci/bmaa020.

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Abstract Gemcitabine is a deoxycytidine analog that has been used for a broad spectrum of tumor, such as nonsmall-cell lung cancer, bladder cancer and pancreatic cancer. Because gemcitabine is hydrophilic, hydrophilic interaction liquid chromatography (HILIC), where analytes are retained on a polar column according to their hydrophilicity, should be adequate for separation analysis of gemcitabine. In the present study, we proposed a hydrophilic interaction chromatography with ultraviolet (HILIC-UV) method with liquid–liquid extraction and adding tetrahydrouridine to plasma samples for gemcitab
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Sentkowska, Aleksandra, Magdalena Biesaga, and Krystyna Pyrzynska. "Application of Hydrophilic Interaction Liquid Chromatography for the Quantification of Flavonoids inGenista tinctoriaExtract." Journal of Analytical Methods in Chemistry 2016 (2016): 1–9. http://dx.doi.org/10.1155/2016/3789348.

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Hydrophilic interaction chromatography (HILIC) was employed to investigate chromatographic behavior of selected flavonoids from their different subgroups differing in polarity. Chromatographic measurements were performed on two different HILIC columns: unmodified silica (Atlantis-HILIC) and zwitterionic sulfoalkylbetaine (SeQuant ZIC-HILIC). Separation parameters such as content and type of organic modifier were studied. On ZIC column retention factors were observed to be inversely proportional to the buffer content in the mobile phase, which is the typical partitioning mechanism. In the case
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Si, Tiantian, Licheng Wang, Xiaofeng Lu, Xiaojing Liang, Shuai Wang, and Yong Guo. "An alternative approach for the preparation of a core–shell bimetallic central metal–organic framework as a hydrophilic interaction liquid chromatography stationary phase." Analyst 145, no. 11 (2020): 3851–56. http://dx.doi.org/10.1039/d0an00304b.

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Wang, Yadi, M. Farooq Wahab, Zachary S. Breitbach, and Daniel W. Armstrong. "Carboxylated cyclofructan 6 as a hydrolytically stable high efficiency stationary phase for hydrophilic interaction liquid chromatography and mixed mode separations." Analytical Methods 8, no. 31 (2016): 6038–45. http://dx.doi.org/10.1039/c6ay01246a.

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Ortiz-Villanueva, Elena, Meritxell Navarro-Reig, Joaquim Jaumot, and Romà Tauler. "Chemometric evaluation of hydrophilic interaction liquid chromatography stationary phases: resolving complex mixtures of metabolites." Analytical Methods 9, no. 5 (2017): 774–85. http://dx.doi.org/10.1039/c6ay02976k.

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Dissertations / Theses on the topic "Hydrophilic Interaction Liquid Chromatoghraphy (HILIC)"

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Bui, Nhat Thi Hong. "Polyhydroxyl and Polyphosphorylcholine functionalized Silica for Hydrophilic interaction liquid Chromatography- Synthesis, characterization and application." Doctoral thesis, Umeå universitet, Kemiska institutionen, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-60600.

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This thesis focuses on the development of new stationary phases for use in hydrophilic interaction liquid chromatography using TRIS-based and phosphorylcholine typed monomers and porous silica particles as starting substrates. In this thesis, several ways of polymerizing highly hydrophilic mono­mers onto pore surfaces of silica supports are described, based on several “grafting from” schemes. “Controlled/living” radical polymerizations including atom transfer radical polymerization (ATRP) and iniferter-mediated polymerization in conjunction with conventional free radical polymerization are dem
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Kamleh, Muhammad Anas. "The combination of hydrophilic interaction liquid chromatography and high resolution mass spectrometry (HILIC-HRMS) : optimisation and application in pharmaceutical analysis." Thesis, University of Strathclyde, 2010. http://oleg.lib.strath.ac.uk:80/R/?func=dbin-jump-full&object_id=22731.

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The development of analytical technology over the last few decades has opened the door to new and intriguing fields of research, allowing investigations at a level of quality not achieved before. Chromatography and mass spectrometry have undergone a revolution of advances in the last four decades with extensive developments in new stationary phases and new developments in ionisation and ion separation techniques. The work in this thesis investigated the application of two of these advances, hydrophilic interaction liquid chromatography (HILIC) and Fourier transformation mass spectrometry (FTMS
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Shah, Heta N. "INVESTIGATION OF PHENYLEPHRINE SULFATION AND INHIBITION USING A NOVEL HILIC ASSAY METHOD." VCU Scholars Compass, 2015. http://scholarscompass.vcu.edu/etd/3952.

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Phenylephrine (PE) is the most commonly used over-the-counter nasal decongestant. The problem associated with phenylephrine is that it undergoes extensive first pass metabolism in the intestinal gut wall leading to its poor and variable oral bioavailability. This research project aims at developing strategies in order to increase the oral bioavailability of PE by co-administration of GRAS compounds. A HILIC assay method was developed to detect the parent drug, phenylephrine (PE) and its sulfate metabolite (PES).The enzyme kinetic studies were done with phenolic dietary or GRAS compounds using
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Palm, Sindy. "Simultan kvantifiering av metylmalon­syra och total homocystein : En kombinationsmetod baserad på hydrofil interaktion vätskekromatografi och elektrospray jonisations­masspektrometri." Thesis, Umeå universitet, Biomedicinsk laboratorievetenskap, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-58642.

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Le, Tinh. "Determination of Cisplatin using Hydrophilic Interaction Liquid Chromatography (HILIC) Coupled with Inductively Coupled Plasma Mass Spectrometry (ICP-MS): A Study on Cisplatin’s Retention Mechanisms in HILIC and Uptake and Intracellular Decay Kinetics in in-vitro Grown Cells." Thesis, Umeå universitet, Kemiska institutionen, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-56554.

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Cisplatin (cis-diamminedichloroplatinum(II), CDDP) is widely used for the treatment of several solid tumors. The antitumor property of cisplatin is generally proved that the covalent binding of cisplatin to DNA distorts the DNA structure, which leads to the death of the cancer cells. The obstacle for chemotherapy is that tumors can acquire resistance to cisplatin and induce the severe side effects associated with cisplatin treatment. How cisplatin enters the cells and metabolizes in cytoplasm is not completely elucidated. The purpose of this project was to study the kinetics of cellular uptake
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Planinc, Ana. "Detection of changes in n-glycosylation profiles of therapeutic glycoproteins using LC-MS." Doctoral thesis, Universite Libre de Bruxelles, 2016. https://dipot.ulb.ac.be/dspace/bitstream/2013/241427/4/Table.pdf.

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Biopharmaceuticals are becoming one of the most promising drugs on the market mainly due to their successful treatment of a vast array of serious diseases, such as cancers, immune disorders, and infections. Structurally, biopharmaceuticals are proteins and it is important to mention that more than 60 % of biopharmaceuticals are glycosylated. Glycosylation is one of the most common posttranslational modifications. It is also the most demanding and the most complex posttranslational modification. The research showed that glycosylation can significantly impact on the safety, efficiency, and quali
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Domingues, Diego Soares. "Desenvolvimento de métodos por cromatografia líquida acoplada à espectrometria de massas em tandem para análises de fármacos (LC-MS/MS no modo column switching com capilar monolítico de sílica híbrida), aminoácidos e neurotransmissores (HILIC-MS/MS) em amostras de plasma de pacientes esquizofrênicos." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/59/59138/tde-03102015-152159/.

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A esquizofrenia é um transtorno neuropsiquiátrico crônico que afeta aproximadamente 1% da população mundial. As teorias neurobiológicas descrevem que a esquizofrenia é essencialmente causada por alterações bioquímicas e estruturais do cérebro, devido às disfunções nos sistemas glutamatérgico, dopaminérgico e serotoninérgico. Desta forma, a determinação das concentrações de aminoácidos e neurotransmissores em amostras de plasma de pacientes esquizofrênicos pode auxiliar na avaliação da eficácia da terapia. Além dos antipsicóticos, medicação de primeira linha no tratamento inicial da esquizofren
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Pinto, Joana Isabel Monteiro. "Healthy pregnancy and prenatal disorders followed by blood plasma metabolomics." Doctoral thesis, Universidade de Aveiro, 2015. http://hdl.handle.net/10773/14784.

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Doutoramento em Bioquímica<br>The work presented in this thesis aimed to investigate the impact of healthy pregnancy and selected prenatal disorders on the metabolome and lipidome of maternal blood plasma, in order to define new potential biomarkers for non-invasive prediction and diagnosis. Chapter 1 describes the present status and challenges of the clinically relevant prenatal disorders, along with a presentation of the metabolomics strategy applied and the state of the art of metabolomics in prenatal research. All experimental details are described in Chapter 2, comprising sample metadata
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Chirita, Raluca-Ioana. "Développement de nouvelles méthodes séparatives compatibles avec une détection par spectrométrie de masse et par électrochimie pour l'analyse de traces de catécholamines et molécules apparentées." Thesis, Orléans, 2009. http://www.theses.fr/2009ORLE2043/document.

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Les catécholamines et les indolamines font partie de la famille des neurotransmetteurs. Un déséquilibre dans leur concentration peut être associé à différentes maladies telles les maladies de Parkinson et Alzheimer, la dépression ou la schizophrénie. C’est pourquoi le développement de méthodes de dosage spécifiques et très sensibles du fait de leurs très faibles teneurs dans les fluides biologiques est nécessaire. Dans un premier temps nous avons développé une méthode chromatographique en appariement d’ions (IP-LC) utilisant des colonnes C18 de nouvelle génération (monolithique et « fused core
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Talebi, M. "New stationary phases for high‐performance liquid chromatography of biomolecules." Thesis, 2013. https://eprints.utas.edu.au/17162/2/Whole-Talebi-thesis-2013.pdf.

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This work presents a study on the preparation and application of polymer monoliths for the liquid chromatography of biomolecules with a focus on the ion‐exchange (IEX) mode. As one important application of polymer monoliths in bioanalysis, charge heterogeneity profiling of monoclonal antibodies (mAbs) in different biopharmaceuticals was performed by developing an elution approach based on shallow pH gradient, generated using single component buffer systems as eluents through cation‐exchange (CEX) monoliths as stationary phases. A useful selection of small molecule buffer species is described
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Books on the topic "Hydrophilic Interaction Liquid Chromatoghraphy (HILIC)"

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Grumbach, Eric S., Kenneth J. Fountain, and Water Corporation Western Australia Staff. Comprehensive Guide to HILIC: Hydrophilic Interaction Chromatography. Waters Corporation, 2010.

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Wang, Perry G., and Weixuan He. Hydrophilic Interaction Liquid Chromatography (HILIC) and Advanced Applications. Taylor & Francis Group, 2011.

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Wang, Perry G., and Weixuan He. Hydrophilic Interaction Liquid Chromatography (HILIC) and Advanced Applications. Taylor & Francis Group, 2017.

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Wang, Perry G. Hydrophilic Interaction Liquid Chromatography (Hilic) and Advanced Applications. Taylor & Francis Group, 2011.

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Wang, Perry G., and Weixuan He. Hydrophilic Interaction Liquid Chromatography (HILIC) and Advanced Applications. Taylor & Francis Group, 2011.

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Hydrophilic interaction liquid chromatography (HILIC) and advanced applications. Taylor & Francis, 2011.

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Book chapters on the topic "Hydrophilic Interaction Liquid Chromatoghraphy (HILIC)"

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Groskreutz, Stephen R., and Dwight R. Stoll. "Theory and Practice of Two-Dimensional Liquid Chromatography Separations Involving the HILIC Mode of Separation." In Hydrophilic Interaction Chromatography. John Wiley & Sons, Inc., 2013. http://dx.doi.org/10.1002/9781118495247.ch9.

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Letzel, Thomas. "Specifications of Gradients in Hydrophilic Interaction Liquid Chromatography (HILIC)." In Gradient HPLC for Practitioners. Wiley-VCH Verlag GmbH & Co. KGaA, 2019. http://dx.doi.org/10.1002/9783527812745.ch6.

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Goli, Mona, Peilin Jiang, Mojibola Fowowe, Md Abdul Hakim, and Yehia Mechref. "Hydrophilic Interaction Liquid Chromatography (HILIC) Enrichment of Glycopeptides Using PolyHYDROXYETHYL A." In Methods in Molecular Biology. Springer US, 2024. http://dx.doi.org/10.1007/978-1-0716-3666-4_16.

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Teleki, Attila, and Ralf Takors. "Quantitative Profiling of Endogenous Metabolites Using Hydrophilic Interaction Liquid Chromatography–Tandem Mass Spectrometry (HILIC-MS/MS)." In Methods in Molecular Biology. Springer New York, 2018. http://dx.doi.org/10.1007/978-1-4939-8757-3_10.

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Jensen, Pia Hønnerup, Simon Mysling, Peter Højrup, and Ole Nørregaard Jensen. "Glycopeptide Enrichment for MALDI-TOF Mass Spectrometry Analysis by Hydrophilic Interaction Liquid Chromatography Solid Phase Extraction (HILIC SPE)." In Methods in Molecular Biology. Humana Press, 2012. http://dx.doi.org/10.1007/978-1-62703-146-2_10.

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"Hydrophilic Interaction Liquid Chromatography (HILIC)." In Handbook of Ion Chromatography. Wiley-VCH Verlag GmbH & Co. KGaA, 2016. http://dx.doi.org/10.1002/9783527651610.ch7.

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Kirtawade, Rupali, Pallavi Salve, Anita Kulkarni, and Pandurang Dhabale. "Hydrophilic Interaction Liquid Chromatography (HILIC): A Review." In Novel Aspects on Pharmaceutical Research Vol. 1. B P International (a part of SCIENCEDOMAIN International), 2023. http://dx.doi.org/10.9734/bpi/napr/v1/8506f.

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Peru, Kerry, Sandra Kuchta, John Headley, and Allan Cessna. "Hydrophilic Interaction Chromatography–Mass Spectrometry." In Hydrophilic Interaction Liquid Chromatography (HILIC) and Advanced Applications. CRC Press, 2011. http://dx.doi.org/10.1201/b10609-9.

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Wang, Ping. "Clinical Applications of Hydrophilic Interaction Liquid Chromatography." In Hydrophilic Interaction Liquid Chromatography (HILIC) and Advanced Applications. CRC Press, 2011. http://dx.doi.org/10.1201/b10609-10.

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Hao, Zhigang. "Polar Functional Groups for HILIC Method." In Hydrophilic Interaction Liquid Chromatography (HILIC) and Advanced Applications. CRC Press, 2011. http://dx.doi.org/10.1201/b10609-12.

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