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Journal articles on the topic 'Hydrotropes'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 July 2025

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1

Prakash, D. Gnana, Pradeep Panneerselvam, Sai Madhusudanan, and V. Aditya. "Hydrotropic Extraction of Xanthones from Mangosteen Pericarp." Advanced Materials Research 984-985 (July 2014): 372–76. http://dx.doi.org/10.4028/www.scientific.net/amr.984-985.372.

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A novel separation process for extraction of xanthones from mangosteen pericarp was investigated using aqueous hydrotrope solution. The hydrotropes sodium salicylate was used for the extraction. The effects of factors such as hydrotrope concentration, extraction temperature and solid loading were investigated by using Response Surface Methodology (RSM). The optimal conditions to obtain the highest yield of xanthones were 2M sodium salicylate, extraction temperature of 40°C and 3% solid loading. This hydrotropic extraction technique is simple and cost effective for the separation of bioactive c

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2

Thenesh-Kumar, S., D. Gnana-Prakash, and N. Nagendra-Gandhi. "The effect of hydrotropes on the solubility and mass transfer coefficient of 2-nitrobenzoic acid." Polish Journal of Chemical Technology 11, no. 2 (2009): 55–59. http://dx.doi.org/10.2478/v10026-009-0025-y.

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The effect of hydrotropes on the solubility and mass transfer coefficient of 2-nitrobenzoic acid A comprehensive investigation on the solubility and mass transfer coefficient enhancement of 2-nitrobenzoic acid through hydrotropy, has been undertaken. The solubility and mass transfer coefficient studies were carried out using hydrotropes such as sodium acetate, citric acid and nicotinamide under a wide range of hydrotrope concentrations (0 to 3.0 mol/L) and different system temperatures (303 to 333 K). It was found that the solubility and mass transfer coefficient of 2-nitrobenzoic acid increas

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3

Maruthi, N.*, M. Hiremath Rudrayyaswamy, P. S. Rithesh, and B. C. Pooja. "SOLUBILITY ENHANCEMENT TECHNIQUE OF CINNARIZINE BY MIXED HYDROTROPY." World Journal of Pharmaceutical Science and Research 3, no. 5 (2024): 407–25. https://doi.org/10.5281/zenodo.14050663.

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Cinnarizine complex is prepared by Mixed Hydrotropy method by using four different hydrotropes such as Sodium citrate, Sodium acetate, Resorcinol and Niacinamide. The prepared Cinnarizine complex were then subjected for characterization of FTIR, DSC, SEM and XRD, solubility, drug content, percentage yield, Micromeretic property and in-vitro drug dissolution. The solubility and dissolution rate of prepared complexes were significantly higher than the pure drug. Initially the solubility of drug is determined by different concentrations of individual hydrotropes viz 10, 20, 30 and 40. The highest

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4

Snehal, Kashid Purva Katore Madhavi Tirkhunde Rutuja Thorat Harshada Padwal* Dr. Vrushali Tambe. "A Review on Solubility Enhancement of Poorly Soluble Drugs by Using Hydrotrophic Agents." International Journal of Pharmaceutical Sciences 3, no. 3 (2025): 2797–808. https://doi.org/10.5281/zenodo.15099654.

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Solubility enhancement of poorly water-soluble drugs remain a significant challenge in pharmaceutical formulation development. Drug solubility is a quite common issue and affects the bioavailability of a drug in the body. Various methods can accommodate to improve solubility of poorly soluble drugs. Hydrotropy is one of the unique technique which can be used to enhance the solubility of poorly water-soluble drugs with many folds by using hydrotropes like sodium citrate, urea, sodium benzoate, etc. Hydrotropes typically contain both a hydrophilic and a hydrophobic component which help to form m

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5

HUSSAIN, NUR IZZAH ATIRAH MAT, NURJANNAH SALIM, SITI NOOR HIDAYAH MUSTAPHA, IZAN IZWAN MISNON, MOHD HASBI AB RAHIM, and RASIDI ROSLAN. "LIGNOCELLULOSE BIOMASS DELIGNIFICATION USING ACID HYDROTROPE AS GREEN SOLVENT: A MINI-REVIEW." Cellulose Chemistry and Technology 57, no. 9-10 (2023): 1017–28. http://dx.doi.org/10.35812/cellulosechemtechnol.2023.57.90.

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"Efficient and cost-effective conversion of lignocellulosic biomass into usable forms of energy presents unique challenges. Lignocellulosic biomass, comprising cellulose, hemicelluloses, and lignin, necessitates advanced conversion technologies. Common commercial delignification techniques, including kraft pulping, sulfite pulping, acid hydrolysis, and organosolv pulping, often involve harsh conditions leading to structural changes in lignin and environmental impacts. To address these issues, acid hydrotropes have emerged as a promising method for lignin extraction. Acid hydrotropes, represent

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6

Gerald, Ugodi W., Mbah J. Chika, Nwodo J. Ngozi, Ozochi A. Oluchi, and Momoh Nafisa. "Utilization of Hydrotropes on Solubilization of Tenoxicam in Aqueous Solution." Asian Journal of Chemical Sciences 14, no. 6 (2024): 98–105. http://dx.doi.org/10.9734/ajocs/2024/v14i6337.

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Hydrotropy is a unique solubilization technique utilize to depict the increase in the solubility of a solute by the addition of a second solute (in large amount) resulting in an increase in the aqueous solubility solute of interest. Therapeutic effectiveness of a drug depends on its aqueous solubility and bioavailability. The purpose of the study was to establish tenoxicam solubility in hydrotropes at very low concentrations as well as explore solubilization behavior of the drug in mixed hydrotropic systems at very low concentrations. The methodology involved the use of rotary flask shaker at

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7

Anum Saif, Rashid Ali Khan, Shahiq Uz Zaman, Muhammad Ali Shahbaz, Atif Sarwar, and Muhammad Nouman Arif. "Effects of Hydrotropic Phenomenon on Solubility Enhancement of Ebastine; Formulation and Characterization." Pharmaceutical Communications 1, no. 01 (2022): 55–69. http://dx.doi.org/10.55627/pharma.001.001.0180.

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Hydrotropes are the nontoxic small organic molecules that at certain concentrations result in solubility enhancement of poorly water-soluble compounds. In this study various hydrotropes including nicotinamide, sodium acetate and trisodium citrate were used at varying ratios to observe the effect on solubility enhancement of Ebastine. Various combinations of drug-hydrotrope complexes were prepared with each above mentioned hydrotropes using solvent evaporation technique. The resultant residues were subjected to various analytical and characterization techniques for verification of complexation

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8

Prachi, Katvate* Dr. Avinash M. Bhagwat Mansi Mane Avantika Bhandugare. "Titrimetric Analysis of Bulk Drug Salicylic Acid Using Hydrotropic Solubilization Method." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 2903–6. https://doi.org/10.5281/zenodo.15450243.

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One of the enhancement techniques is hydrotropic solubilization, which uses hydrotropes like sodium citrate, sodium benzoate, urea, etc., to greatly increase solubility. This method has several advantages, such as not requiring organic solvents, chemically modifying hydrophobic drugs, or preparing emulsion systems.This study aims to use hydrotropy to a specific problem: how to make the medicine ibuprofen more soluble in 0.1 M ammonium acetate.Ionic organic salts considered as hydrotropic agent.These days, hydrotropic agents are being utilized to increase the therapeutic efficiency and bioavail

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9

Nainwal, Nidhi, Sunil Jawala, Ranjit Singh, and Vikas A. Saharan. "Solubility-Permeability Interplay of Hydrotropic Solubilization Using Response Surface Methodology." Drug Delivery Letters 10, no. 3 (2020): 209–18. http://dx.doi.org/10.2174/2210303110666200220124230.

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Background:: The solubility/dissolution of a drug in the gastrointestinal (GI) region and the permeability of a drug through the GI membrane are the two key parameters governing drug absorption. Poor aqueous solubility is the rate-limiting factor for the absorption of poorly soluble drugs through the GI region. Objective: The purpose of this work is to investigate the influence of two different hydrotropes, namely sodium benzoate (SB), and nicotinamide (NA), at different levels (10-40%) and in combination on the solubility and permeability of poorly soluble drug glibenclamide (GLB). The work w

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10

Ibrahim, Naz, Shahla Smail, Nozad Hussein, and Tara Abdullah. "Solubility enhancement of nimodipine using mixed hydrotropic solid dispersion technique." Zanco Journal of Medical Sciences 24, no. 3 (2020): 386–94. http://dx.doi.org/10.15218/zjms.2020.046.

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Background and objective: Low aqueous solubility of active pharmaceutical ingredients has an effect on both formulation development and bioavailability. Nimodipine is an antihypertensive agent with low oral bioavailability, which might be attributed to the extremely poor water solubility. This study aimed to increase the solubility of nimodipine in water using hydrotropes and solid dispersion technology to increase dissolution rate compared to the marketed drug product. Methods: Solubility of nimodipine was determined separately in sodium acetate, sodium citrate, sodium benzoate, and niacinami

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11

Shimizu, Seishi, and Nobuyuki Matubayasi. "The origin of cooperative solubilisation by hydrotropes." Physical Chemistry Chemical Physics 18, no. 36 (2016): 25621–28. http://dx.doi.org/10.1039/c6cp04823d.

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The signature of hydrotropic solubilisation is the sigmoidal solubility curve; when plotted against hydrotrope concentration, solubility increases suddenly after the minimum hydrotrope concentration (MHC), and reaches a plateau at higher hydrotrope concentrations. Here we explain the origin of hydrotropic cooperativity based on statistical thermodynamics.

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12

Rashma, L. Judith, S. I. David Presley, and D. Gnana Prakash. "Extraction of geraniol from palmarosa oil using hydrotropic solvents." Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas 23, no. 3 (2024): 382–89. http://dx.doi.org/10.37360/blacpma.24.23.3.26.

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The extraction of geraniol from palmarosa oil using hydrotropic solvents was investigated. Palmarosa oil possesses an appealing rose aroma and properties like anti-inflammatory, antifungal, and antioxidant due to the presence of geraniol. The extraction of geraniol from palmarosa oil by using distillation methods like steam distillation and fractional distillation was a laborious process. So hydrotropes were tried for extraction. The geraniol yield and purity depend on parameters like concentration of hydrotrope, solvent volume ratio, and time period. Using the Box Benkhem Design (BBD), the ex

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13

Dhinakaran, M., Antony Bertie Morais, and N. Nagendra Gandhi. "Separation of m/p-Aminoacetophenone Using Hydrotropy." E-Journal of Chemistry 9, no. 4 (2012): 2006–14. http://dx.doi.org/10.1155/2012/504767.

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The aqueous solubilities of m/p-aminoacetophenone in different concentrations (0-3.0 mol/L) of hydrotropes such as diethyl nicotinamide, sodium pseudocumene sulfonate and sodium thiocyanate solutions at different system temperatures (303K to 333K) were studied. The percentage extraction (%E) of m- aminoacetophenone from m/p-aminoacetophenone mixture increases with increase in hydrotrope concentration. A Minimum Hydrotrope Concentration (MHC) in the aqueous phase was required to initiate the significance of the %E of m-aminoacetophenone. Percentage extraction (%E) is the ratio of moles of m-ami

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14

Amareshwar, Shabada* Yellanki Prashanthi CH. Yella Reddy Boya Vivekananda. "FORMULATION DEVELOPMENT AND EVALUATION OF HYDROTROPIC SOLUBILIZATION BASED SUSPENSIONS OF ITRACONAZOLE." Indo American Journal of Pharmaceutical Sciences 04, no. 11 (2017): 4425–34. https://doi.org/10.5281/zenodo.1064832.

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Hydrotropic solublization is new, simple, economic, safe method, can be used in analysis of drug. The use of various hydrotropes in place of organic solvents for the purpose of solubilization. Hydrotropes increases the solubility of organics in water. Objective of present investigation was to enhance the solubility of Itraconazole using the technique of hydrotropic solubilization technique and convert them into suitable oral liquid dosage form (suspension) useful for enhancement of bioavailability.0.5M, 1M, 2M of the hydrotropes (trisodium citrate, urea, sodium acetate, sodium benzoate and sod

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15

Prakash, D. Gnana, S. Thenesh Kumar, and N. Nagendra Gandhi. "Enhancement of Solubility and Mass Transfer Coefficient of Benzoic Acid Through Hydrotropy." Polish Journal of Chemical Technology 15, no. 1 (2013): 46–50. http://dx.doi.org/10.2478/pjct-2013-0009.

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The effect of hydrotropes such as sodium salicylate, sodium benzoate, and nicotinamide on the solubility and mass transfer coefficient of benzoic acid has been investigated. The solubility studies were carried out under a wide range of hydrotrope concentrations (0 to 3.0 mol/L) and different system temperatures (303K to 333K). It has been observed that the solubility and mass transfer coefficient of benzoic acid increases with an increase in hydrotrope concentration and also with system temperature. A Minimum Hydrotrope Concentration (MHC) was found essential to initiate a significant increase

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16

Sintra, T. E., K. Shimizu, S. P. M. Ventura, S. Shimizu, J. N. Canongia Lopes, and J. A. P. Coutinho. "Enhanced dissolution of ibuprofen using ionic liquids as catanionic hydrotropes." Physical Chemistry Chemical Physics 20, no. 3 (2018): 2094–103. http://dx.doi.org/10.1039/c7cp07569c.

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17

Labrath, Y. P. "Hydrotropic Extraction for Process Intensification in Delignification of Dried Jackfruit (Artocarpus heterophyllus) Leaves." International Journal of Biochemistry Research & Review 34, no. 3 (2025): 67–81. https://doi.org/10.9734/ijbcrr/2025/v34i3986.

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Background: The extraction of lignin is costliest, challenging process and is significant for production of various starting material useful in chemical synthesis, fuel production, weakening of cell wall to assists the extraction of natural active constituents from plants, in solid waste management and delignification assists in breaking of strong bonds of lignin and hemicellulose which entraps the fermentable cellulose. There is huge dried leaf waste, which has lignin component suitable for various applications. Further, the available lignin extraction methods affect the quality of lignin. Ai

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18

Aime, Aliunui, Harpritkaur Bagga, Gunjan Chaudhari, and Ujwal Vyas. "Novel Approaches and Emerging Trends in Hydrotropic Solubilization Technology." INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY 14, no. 03 (2024): 1736–44. http://dx.doi.org/10.25258/ijddt.14.3.69.

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Hydrotropic solubilization technology enhances the solubility and bioavailability of poorly water-soluble drugs, a major challenge in pharmaceutical research. This review discusses hydrotropic agents’ structures, the solubilization process, and factors affecting drug solubility. It explores optimizing agent concentrations, the role of computer modeling and QSAR studies, and hydrotropes’ impact on overcoming biological barriers and improving pharmacokinetics and pharmacodynamics. The review highlights hydrotropic compounds’ potential in advancing pharmaceutical formulations and clinical applica

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19

Gaspar, Rita, Marcelo Coelho dos Santos Muguet, and Pedro Fardim. "Advanced Fractionation of Kraft Lignin by Aqueous Hydrotropic Solutions." Molecules 28, no. 2 (2023): 687. http://dx.doi.org/10.3390/molecules28020687.

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Lignin is an underutilized high-potential biopolymer that has been extensively studied over the past few decades. However, lignin still has drawbacks when compared with well-known petroleum-based equivalents, and the production of tailored lignin fractions is highly in demand. In this work, a new method for the fractionation of Lignoboost Kraft Lignin (LKL) is proposed by using two different hydrotropes: sodium xylenesulfonate (SXS) and sodium cumenesulfonate (SCS). The different fractions are obtained by sequentially decreasing the hydrotropic concentration with the addition of water. Four an

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20

Friberg, Stig E., and Miin Chiu. "HYDROTROPES." Journal of Dispersion Science and Technology 9, no. 5 (1988): 443–57. http://dx.doi.org/10.1080/01932698808944004.

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21

Friberg, Stig E. "Hydrotropes." Current Opinion in Colloid & Interface Science 2, no. 5 (1997): 490–94. http://dx.doi.org/10.1016/s1359-0294(97)80096-9.

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22

Kunz, Werner, Krister Holmberg, and Thomas Zemb. "Hydrotropes." Current Opinion in Colloid & Interface Science 22 (April 2016): 99–107. http://dx.doi.org/10.1016/j.cocis.2016.03.005.

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23

Eastoe, Julian, Marios Hopkins Hatzopoulos, and Peter J. Dowding. "Action of hydrotropes and alkyl-hydrotropes." Soft Matter 7, no. 13 (2011): 5917. http://dx.doi.org/10.1039/c1sm05138e.

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24

Dawid, Mikulski, and Kłosowski Grzegorz. "Microwave-assisted hydrotropic pretreatment as a new and highly efficient way to cellulosic ethanol production from maize distillery stillage." Applied Microbiology and Biotechnology 105, no. 8 (2021): 3381–92. http://dx.doi.org/10.1007/s00253-021-11258-2.

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Abstract Aim of the study was to assess the suitability of the combined use of microwave radiation and sodium cumene sulfonate under optimized process conditions for the preparation of maize stillage biomass as a raw material for the production of cellulosic ethanol. The key parameter guaranteeing a high level of lignin removal from biomass (ca. 44%) was concentration of hydrotrope. Even at high biomass concentration (16% w/v) and a cellulase enzyme dose of about 4 filter-paper units/g, maize stillage biomass subjected to microwave-assisted hydrotropic pretreatment was highly susceptible to en

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25

Neha, Shivathaya*1 Aliza Bagaban2 Suhel Mulla2 Nivedita Kappattanavar2 Sahana Khavatakoppa2 and Swaroop Karaguppi2. "Formulation And Evaluation of Ibuprofen Tablets Using Hydrotropic Solid Dispersion Technique." International Journal of Pharmaceutical Sciences 3, no. 3 (2025): 3285–97. https://doi.org/10.5281/zenodo.15111441.

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Ibuprofen, a non-steroidal anti-inflammatory drug (NSAID), belongs to Class II of the Biopharmaceutical Classification System, characterized by low aqueous solubility and high permeability, which limits its dissolution and oral bioavailability. This study aims to enhance the solubility of Ibuprofen through hydrotropy-based solid dispersion and evaluate its tablet formulations. Various hydrotropes were screened for solubility enhancement, with sodium benzoate demonstrating the highest solubility of 18.73 mol/L. A solid dispersion of Ibuprofen was prepared using a drug-to-hydrotrope ratio of 1:3

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26

Friberg, Stig E., Chris Brancewicz, and David S. Morrison. "O/W Microemulsions and Hydrotropes: The Coupling Action of a Hydrotrope." Langmuir 10, no. 9 (1994): 2945–49. http://dx.doi.org/10.1021/la00021a016.

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27

Neumann, Miguel G., Carla C. Schmitt, Katia R. Prieto, and Beatriz E. Goi. "The photophysical determination of the minimum hydrotrope concentration of aromatic hydrotropes." Journal of Colloid and Interface Science 315, no. 2 (2007): 810–13. http://dx.doi.org/10.1016/j.jcis.2007.07.020.

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28

Kazi, Maseera Rizwan, Sanket Gandhi, Shubham V. Desai, Rohan Barse, and Vijay Jagtap. "Review: Hydrotropy as Prominent Approach for Enhancement of Aqueous Solubility of Drugs." Journal of Drug Delivery and Therapeutics 12, no. 4 (2022): 231–36. http://dx.doi.org/10.22270/jddt.v12i4.5461.

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Solubility is crucial element to achieve the desired drug absorption in the total pharmacological response. Low water solubility can considerably limit the medication efficacy, and to improve aqueous solubility, a variety of approaches are employed. The capacity which increases water solubility for particular drug can thus be a useful tool for enhancing efficiency and/or decreasing negative effects. This is true for parental administered, topically applied and orally consumed solutions. It is a difficult work for researchers and pharmaceutical scientist to use solubility features in bioavailab

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29

Gaikar, V. G., and M. M. Sharma. "Separations with hydrotropes." Separations Technology 3, no. 1 (1993): 2–11. http://dx.doi.org/10.1016/0956-9618(93)80001-8.

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30

Friberg, Stig E., Robert V. Lochhead, Irena Blute, and Torbjörn Wärnheim. "Hydrotropes—Performance Chemicals." Journal of Dispersion Science and Technology 25, no. 3 (2004): 243–51. http://dx.doi.org/10.1081/dis-120037685.

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31

Bergfeld, Wilma F., Donald V. Belsito, Curtis D. Klaassen, et al. "Safety Assessment of Xylene Sulfonic Acid, Toluene Sulfonic Acid, and Alkyl Aryl Sulfonate Hydrotropes as Used in Cosmetics." International Journal of Toxicology 30, no. 6_suppl (2011): 270S—283S. http://dx.doi.org/10.1177/1091581811429085.

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Xylene sulfonic acid, toluene sulfonic acid, and alkyl aryl sulfonate hydrotropes used in cosmetics as surfactants, hydrotropes, were reviewed in this safety assessment. The similar structure, properties, functions, and uses of these ingredients enabled grouping them and using the available toxicological data to assess the safety of the entire group. The Cosmetic Ingredient Review Expert Panel reviewed relevant animal and human data related to these ingredients. The panel concluded that xylene sulfonic acid and alkyl aryl sulfonate hydrotropes are safe as cosmetic ingredients in the present pr

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32

Dandekar, Deepak, G. K. Jayaprakasha, and Bhimanagouda Patil. "Citrus Bioactive Limonoid Extraction using Environment-friendly Hydrotropy." HortScience 41, no. 4 (2006): 1008C—1008. http://dx.doi.org/10.21273/hortsci.41.4.1008c.

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Citrus consumption has been shown to promote human health due to presence of several bioactive compounds. In the process of understanding the health benefits of citrus, we need to isolate and characterize these compounds. Limonoids are one of such prominent, but lesser-known phytonutrients that have been shown to prevent cancers of the mouth, skin, lung, breast, and colon. With the growing interest in the health-promoting properties of citrus limonoids, the demand for these bioactives has significantly increased. It has been critical to explore environment-friendly extraction methods rather th

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33

Alves, Luís, Solange Magalhães, Cátia Esteves, Marco Sebastião, and Filipe Antunes. "Synergisms between Surfactants, Polymers, and Alcohols to Improve the Foamability of Mixed Systems." J 7, no. 2 (2024): 169–82. http://dx.doi.org/10.3390/j7020010.

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In order to produce detergents with improved performance and good market acceptability, it is crucial to develop formulations with improved foamability and cleaning performance. The use of a delicate balance of surfactants and additives is an appealing strategy to obtain good results and enables a reduction in the amount of chemicals used in formulations. Mixtures of hydrophobically modified linear polymers and surfactants, as well as balanced mixtures with co-surfactants and/or hydrotropes, are the most effective parameters to control foamability and foam stability. In the present study, the

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34

Liu, Bin, Shuo Yin, Xia Wu, et al. "Interactions Between Cationic Micellar Solution and Aromatic Hydrotropes with Subtle Structural Variations." Molecules 29, no. 22 (2024): 5482. http://dx.doi.org/10.3390/molecules29225482.

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Wormlike micelles (WLMs) with tunable viscoelastic characteristics have emerged as indispensable smart materials with a wide range of applications, which have garnered intense interest over the past few decades. However, quantitatively predicting the effect of various hydrotropes on the rheological behaviors of WLMs remains a challenge. In this article, micelles were formed in a mixture of 3-hexadecyloxy-2-hydroxypropyltrimethylammonium bromide (R16HTAB) and aromatic hydrotropes (e.g., sodium benzoate, sodium cinnamate and their derivatives, respectively) in an aqueous solution. The phase beha

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35

Matero, Anna, Åsa Mattsson, and Martin Svensson. "Alkyl polyglucosides as hydrotropes." Journal of Surfactants and Detergents 1, no. 4 (1998): 485–89. http://dx.doi.org/10.1007/s11743-998-0046-y.

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36

Agarwal, Mamta, and Vilas G. Gaikar. "Extractive separations using hydrotropes." Separations Technology 2, no. 2 (1992): 79–84. http://dx.doi.org/10.1016/0956-9618(92)80010-b.

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37

Hopkins Hatzopoulos, Marios, Julian Eastoe, Peter J. Dowding, Sarah E. Rogers, Richard Heenan, and Robert Dyer. "Are Hydrotropes Distinct from Surfactants?" Langmuir 27, no. 20 (2011): 12346–53. http://dx.doi.org/10.1021/la2025846.

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38

GAIKAR, V. G., and M. M. SHARMA. "NOTE: EXTRACTIVE SEPARATIONS WITH HYDROTROPES." Solvent Extraction and Ion Exchange 4, no. 4 (1986): 839–46. http://dx.doi.org/10.1080/07366298608917896.

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39

Subbarao, C. V., I. P. K. Chakravarthy, A. V. S. L. Sai Bharadwaj, and K. M. M. Prasad. "Functions of Hydrotropes in Solutions." Chemical Engineering & Technology 35, no. 2 (2012): 225–37. http://dx.doi.org/10.1002/ceat.201100484.

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40

Sethi, Vaishali, Jayanti Mishra, Arpan Bhattacharyya, Debasis Sen, and Ashok K. Ganguli. "Hydrotrope induced structural modifications in CTAB/butanol/water/isooctane reverse micellar systems." Physical Chemistry Chemical Physics 19, no. 33 (2017): 22033–48. http://dx.doi.org/10.1039/c7cp03191b.

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41

Kang, Xin, Wanli Kang, Hongbin Yang, et al. "pH-Responsive aggregates transition from spherical micelles to WLMs induced by hydrotropes based on the dynamic imine bond." Soft Matter 16, no. 42 (2020): 9705–11. http://dx.doi.org/10.1039/d0sm01413c.

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42

Herbinski, Aurélien, Estelle Métay, Eric Da Silva, Estelle Illous, Jean-Marie Aubry, and Marc Lemaire. "An eco-compatible pathway to new hydrotropes from tetraols." Green Chemistry 20, no. 6 (2018): 1250–61. http://dx.doi.org/10.1039/c7gc02990j.

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43

Abranches, Dinis O., Bruna P. Soares, Ana M. Ferreira, Seishi Shimizu, Simão P. Pinho, and João A. P. Coutinho. "The impact of size and shape in the performance of hydrotropes: a case-study of alkanediols." Physical Chemistry Chemical Physics 24, no. 13 (2022): 7624–34. http://dx.doi.org/10.1039/d2cp00496h.

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Cláudio, Ana Filipa M., Márcia C. Neves, Karina Shimizu, José N. Canongia Lopes, Mara G. Freire, and João A. P. Coutinho. "The magic of aqueous solutions of ionic liquids: ionic liquids as a powerful class of catanionic hydrotropes." Green Chemistry 17, no. 7 (2015): 3948–63. http://dx.doi.org/10.1039/c5gc00712g.

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Song, Yanliang, Richard P. Chandra, Xu Zhang, Tianwei Tan, and Jack N. Saddler. "Comparing a deep eutectic solvent (DES) to a hydrotrope for their ability to enhance the fractionation and enzymatic hydrolysis of willow and corn stover." Sustainable Energy & Fuels 3, no. 5 (2019): 1329–37. http://dx.doi.org/10.1039/c8se00617b.

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Olaru, Iulia Ioana, Dragos Paul Mihai, Octavian Tudorel Olaru, et al. "Comparative Toxicological Evaluation of Solubilizers and Hydrotropic Agents Using Daphnia magna as a Model Organism." Environments 12, no. 5 (2025): 172. https://doi.org/10.3390/environments12050172.

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Improving the aqueous solubility of poorly soluble pharmaceuticals is essential for accurate pharmacotoxicological testing, but the biological safety of solubilizers and hydrotropic agents used for this purpose requires careful evaluation. This study assessed the acute toxicity, physiological parameters (heart rate, claw and appendage movement), behavioral responses (swimming speed), and embryotoxicity of 15 commonly used solubilizers and hydrotropes using Daphnia magna as a biological model. Compounds included surfactants (polysorbate 20 (Tween 20), polysorbate 80 (Tween 80), sodium lauryl su

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Ansari, Khursheed B., and Vilas G. Gaikar. "Green hydrotropic extraction technology for delignification of sugarcane bagasse by using alkybenzene sulfonates as hydrotropes." Chemical Engineering Science 115 (August 2014): 157–66. http://dx.doi.org/10.1016/j.ces.2013.10.042.

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Abranches, Dinis O., Jordana Benfica, Bruna P. Soares, et al. "Unveiling the mechanism of hydrotropy: evidence for water-mediated aggregation of hydrotropes around the solute." Chemical Communications 56, no. 52 (2020): 7143–46. http://dx.doi.org/10.1039/d0cc03217d.

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AGARWAL, MAMTA, and V. G. GAIKAR. "EXTRACTIVE DISTILLATION WITH AQUEOUS SOLUTIONS OF HYDROTROPES." Chemical Engineering Communications 115, no. 1 (1992): 83–94. http://dx.doi.org/10.1080/00986449208936030.

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Venkatesh, Nagasamy. "Solubility enhancement of terbinafine hydrochloride by hydrotropic technique." Journal of medical pharmaceutical and allied sciences 12, no. 1 (2023): 5596–603. http://dx.doi.org/10.55522/jmpas.v12i1.4067.

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Terbinafine hydrochloride is an antifungal drug belonging to the class of allylamines. The drug exhibits poor aqueous solubility and thus results in decrease in oral bioavailability. In the present study, an attempt was made to enhance the solubility of terbinafine hydrochloride using hydrotropic solubilization technique employing different hydrotropesnamely sodium benzoate and ureain different proportions and their combinations. The different hydrotropes were selected based on the saturation solubility exhibited by the drug. Among them best batches of the drughydrotrope combinations of varyin

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