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Journal articles on the topic 'Hydroxy proline'

Author: Grafiati

Published: 7 June 2025

Last updated: 2 August 2025

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1

Long, Mengfei, Meijuan Xu, Zhenfeng Ma, et al. "Significantly enhancing production of trans-4-hydroxy-l-proline by integrated system engineering in Escherichia coli." Science Advances 6, no. 21 (2020): eaba2383. http://dx.doi.org/10.1126/sciadv.aba2383.

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Trans-4-hydroxy-l-proline is produced by trans-proline-4-hydroxylase with l-proline through glucose fermentation. Here, we designed a thorough “from A to Z” strategy to significantly improve trans-4-hydroxy-l-proline production. Through rare codon selected evolution, Escherichia coli M1 produced 18.2 g L−1l-proline. Metabolically engineered M6 with the deletion of putA, proP, putP, and aceA, and proB mutation focused carbon flux to l-proline and released its feedback inhibition. It produced 15.7 g L−1trans-4-hydroxy-l-proline with 10 g L−1l-proline retained. Furthermore, a tunable circuit base

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2

de Aquino, Pedro Everson Alexandre, Ítalo Rosal Lustosa, Caren Nádia Soares de Sousa, et al. "The N-Methyl-(2S, 4R)-trans-4-hydroxy-L-proline-Enriched Methanol Fraction from Sideroxylon obtusifolium Shows an Anticonvulsant Activity Associated with its Anti-inflammatory/Antioxidant Actions." Planta Medica International Open 07, no. 04 (2020): e158-e169. http://dx.doi.org/10.1055/a-1328-5093.

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AbstractEpilepsy is a neurological disorder characterized by recurrent seizures, resulting from excessive neuronal discharges. Sideroxylon obtusifolium is used in Brazil for its anti-inflammatory/antioxidant properties, known to be involved with epilepsy. The anticonvulsant effects of the methanol fraction from S. obtusifolium leaves, rich in N-methyl-(2S,4R)-trans-4-hydroxy-L-proline, were investigated on pilocarpine- and pentylenetetrazole-induced convulsion models. Mice were pretreated with N-methyl-(2S,4R)-trans-4-hydroxy-L-proline (50, 100, 200 mg/kg, p.o.) and, 1 h later, by pilocarpine

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3

Smith, Jessica A., G. Paul Savage, and Oliver E. Hutt. "Studies on the Synthesis of cis-4-Hydroxy-L-proline." Australian Journal of Chemistry 64, no. 11 (2011): 1509. http://dx.doi.org/10.1071/ch11204.

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A high yielding practical three-step procedure, which relies on an extractive work-up procedure, has been developed to convert N-phenylsulfonyl-trans-4-hydroxy-l-proline to N-phenylsulfonyl-cis-4-hydroxy-l-proline methyl ester in 82 % yield over three steps.

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4

Ferrario, Eugenio, Riccardo Miggiano, Menico Rizzi та Davide M. Ferraris. "Structure of Thermococcus litoralis Δ1-pyrroline-2-carboxylate reductase in complex with NADH and L-proline". Acta Crystallographica Section D Structural Biology 76, № 5 (2020): 496–505. http://dx.doi.org/10.1107/s2059798320004866.

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L-Hydroxyproline (L-Hyp) is a nonstandard amino acid that is present in certain proteins, in some antibiotics and in the cell-wall components of plants. L-Hyp is the product of the post-translational modification of protein prolines by prolyl hydroxylase enzymes, and the isomers trans-3-hydroxy-L-proline (T3LHyp) and trans-4-hydroxy-L-proline (T4LHyp) are major components of mammalian collagen. T4LHyp follows two distinct degradation pathways in bacteria and mammals, while T3LHyp is metabolized by a two-step metabolic pathway that is conserved in bacteria and mammals, which involves a T3LHyp d

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5

Jain, Vipin Kumar. "Diastereoselective Synthesis of (–)-Bestatin, Epibestatin, Phebestin and (3S,4R)-4-Amino-3-hydroxy-5-phenylpentanoic Acid from an Aldehyde Derived from d-Phenylalanine." SynOpen 03, no. 04 (2019): 114–23. http://dx.doi.org/10.1055/s-0039-1690223.

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A convenient and efficient method for the synthesis of (–)-bestatin, epibestatin, phebestin, and (3S,4R)-4-amino-3-hydroxy-5-phenylpentanoic acid is reported. The key step is a proline-catalyzed α-hydroxylation of an aldehyde derived from d-phenylalanine, which leads to incorporation of a hydroxyl group at the α-position of that aldehyde with good yield and very high diastereoselectivity. Bestatin and its diastereomer epibestatin are synthesized from the same starting material using the same sequence of reactions, except for proline as the catalyst. An O-MOM and Boc-protected amino acid, a co

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6

MacLean, Allyson M., Catharine E. White, Jane E. Fowler, and Turlough M. Finan. "Identification of a Hydroxyproline Transport System in the Legume Endosymbiont Sinorhizobium meliloti." Molecular Plant-Microbe Interactions® 22, no. 9 (2009): 1116–27. http://dx.doi.org/10.1094/mpmi-22-9-1116.

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Hydroxyproline-rich proteins in plants offer a source of carbon and nitrogen to soil-dwelling microorganisms in the form of root exudates and decaying organic matter. This report describes an ABC-type transport system dedicated to the uptake of hydroxyproline in the legume endosymbiont Sinorhizobium meliloti. We have designated genes involved in hydroxyproline metabolism as hyp genes and show that an S. meliloti strain lacking putative transport genes (ΔhypMNPQ) is unable to grow with or transport trans-4-hydroxy-l-proline when this compound is available as a sole source of carbon. Expression

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7

Hasegawa, H., and S. Mori. "Non-proline-accumulating rice mutants resistant to hydroxy-L-proline." Theoretical and Applied Genetics 72, no. 2 (1986): 226–30. http://dx.doi.org/10.1007/bf00266996.

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8

Minguillón, Cristina, Teresa González, Olga Abad, and M. Carmen Santano. "Synthetic Studies onl-Proline and (4 R )-Hydroxy-l-proline Derivatives." Synthesis 2004, no. 08 (2004): 1171–82. http://dx.doi.org/10.1055/s-2004-822384.

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9

T. Mohd Ali, M., and . "Synthesis of -Hydroxy -Proline: Potential for Organocataly-sis Reactions." International Journal of Engineering & Technology 7, no. 4.14 (2019): 237. http://dx.doi.org/10.14419/ijet.v7i4.14.27571.

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A chiral organic molecule, L-proline catalyzed an enantioselective transformation reaction has becoming interesting synthetic protocol especially in the area of organocatalysis. Herein, a synthetic approach towards -hydroxy--proline starting from bicyclic lactone lactam is hereby described. The syntheses utilized dicarboxylation reaction of bicyclic lacton lactam, followed by ether hydrolysis of the bicyclic ether and oxidation reaction of the primary alcohol. The synthetic strategy disclosed here allows further the enantioselective synthesis of a variety of unnatural amino acids based on -

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10

Naidu, Bodapati P., Leslie G. Paleg, and Graham P. Jones. "Accumulation of proline analogues and adaptation of Melaleuca species to diverse environments in Australia." Australian Journal of Botany 48, no. 5 (2000): 611. http://dx.doi.org/10.1071/bt99059.

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The genus Melaleuca is native to Australia, with about 250 species spread from favourable to very stressful ecological habitats. We analysed the leaves of 125 Melaleuca species for the accumulation of proline analogues to explore relationships between the ability of the species to accumulate proline analogues and their ability to adapt to various stressful habitats in Australia. Melaleuca species that have evolved the ability to accumulate only L-proline seem to be adapted to non-saline or non-sodic soils in regions of higher rainfall. Species that accumulate N-methyl-L-proline seem to be adap

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11

Naidu, BP, GP Jones, LG Paleg, and A. Poljakoff-Mayber. "Proline Analogues in Melaleuca Species: Response of Melaleuca lanceolata and M. uncinata to Water Stress and Salinity." Functional Plant Biology 14, no. 6 (1987): 669. http://dx.doi.org/10.1071/pp9870669.

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Fifteen species of Melaleuca and two species of Callistemon from the field were examined to determine whether they accumulated nitrogen-containing compatible solutes and, if so, which. In addition to L-proline, N-methyl-L-proline (MP) (isolated for the first time from plants), trans-4-hydroxy-N-methyl- L-proline (MHP), and N, N'-dimethyl-trans-4-hydroxy-L-proline (DHP) were found in various combinations in the 15 Melaleuca species. M. lanceolata seedlings were subjected to water or salinity stress and M. uncinata to water stress under laboratory conditions. In both species significant reductio

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12

Janská, A., S. Zelenková, M. Klíma, M. Vyvadilová, and T. I. Prášil. "Freezing tolerance and proline content of in vitro selected hydroxyproline resistant winter oilseed rape." Czech Journal of Genetics and Plant Breeding 46, No. 1 (2010): 35–40. http://dx.doi.org/10.17221/52/2009-cjgpb.

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Twelve doubled haploid (DH) winter oilseed rape plants with altered levels of proline and/or freezing tolerance were obtained by in vitro selection for resistance to trans-4-hydroxy-l-proline (Hyp) in five segregating microspore populations. No significant response to selection either in proline content or in freezing tolerance, compared with the non-selected control populations, was observed. When data from all examined materials were combined, a weak correlation between proline content and freezing tolerance was observed.

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13

Kumar, H. Vijay, C. R. Gnanendra, and Nagaraja Naik. "Synthesis of Amino Acid Analogues of 5H-Dibenz[b,f]azepine and Evaluation of their Radical Scavenging Activity." E-Journal of Chemistry 6, no. 1 (2009): 125–32. http://dx.doi.org/10.1155/2009/361490.

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A method for the synthesis of tyrosine, phenyl alanine, hydroxy proline and threonine free amino acid analogues of 5H-dibenz[b,f]azepine is proposed. 5H-dibenz[b,f]azepine was prepared by known method. The key intermediate 3-chloro-1-(5H-dibenz[b,f]azepine-5-yl)propan-1-one was obtained byN-acylation of 5H-dibenz[b,f]azepine with 3-chloro propionyl chloride. Further coupling of respective free amino acid to produce 2-(3-(5H-dibenz[b,f]azepine-5-yl)-3-oxopropylamino)3-(4 hydroxyphenyl) propanoic acid, 2-(3-(5H-dibenz[b,f]azepine-5-yl)-3-oxopropylamino)-3-phenyl propanoicacid,1-(3-(5H-dibenz[b,f

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14

Dong, Chuan-Ming, Li-Gong Chen, Xue-Min Duan, Xue-Gui Shu, Tao Zeng, and Yang Li. "N-(2-Hydroxy-1-naphthylmethyl)-(S)-proline." Acta Crystallographica Section E Structure Reports Online 61, no. 4 (2005): o960—o961. http://dx.doi.org/10.1107/s1600536805006859.

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15

Sigmund, Amy E., Wonpyo Hong, Rafael Shapiro, and Robert DiCosimo. "Chemoenzymatic Synthesis ofcis-4-Hydroxy-D-proline." Advanced Synthesis & Catalysis 343, no. 6-7 (2001): 587–90. http://dx.doi.org/10.1002/1615-4169(200108)343:6/7<587::aid-adsc587>3.0.co;2-v.

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16

Taylor, C. M., C. A. Weir, and C. G. Jørgensen. "Synthesis of D-Galactopyranosides of trans-4-Hydroxy-L-proline Utilizing the Sulfoxide Glycosylation Method." Australian Journal of Chemistry 55, no. 2 (2002): 135. http://dx.doi.org/10.1071/ch01156.

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Phenyl 1-thio-β-D-galactopyranoside (1) was converted into two sulfoxide glycosyl donors: phenyl (2,3,4,6-tetra-O-benzyl)-1-thio-β-D-galactopyranoside S-oxide (3) and phenyl (2,3,4,6-tetra-O-pivaloyl)- 1-thio-β-D-galactopyranoside S-oxide (5). These glycosyl donors were then each reacted with Na- fluorenylmethoxycarbonyl-trans-4-hydroxy-L-proline allyl ester (7). The glycosylation reactions were conducted at -70°C with triflic anhydride as promotor, in the presence of 2,6-di-tert-butyl-4-methylpyridine. In the case of the perbenzylated sulfoxide donor (3), the major product was Na-fluorenylmet

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17

Chen, Siyun, Catharine E. White, George C. diCenzo, et al. "l-Hydroxyproline and d-Proline Catabolism in Sinorhizobium meliloti." Journal of Bacteriology 198, no. 7 (2016): 1171–81. http://dx.doi.org/10.1128/jb.00961-15.

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ABSTRACTSinorhizobium melilotiforms N2-fixing root nodules on alfalfa, and as a free-living bacterium, it can grow on a very broad range of substrates, includingl-proline and several related compounds, such as proline betaine,trans-4-hydroxy-l-proline (trans-4-l-Hyp), andcis-4-hydroxy-d-proline (cis-4-d-Hyp). Fourteenhypgenes are induced upon growth ofS. melilotiontrans-4-l-Hyp, and of those,hypMNPQencodes an ABC-typetrans-4-l-Hyp transporter andhypREencodes an epimerase that convertstrans-4-l-Hyp tocis-4-d-Hyp in the bacterial cytoplasm. Here, we present evidence that the HypO, HypD, and HypH

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18

Shibasaki, Takeshi, Hideo Mori, Shigeru Chiba, and Akio Ozaki. "Microbial Proline 4-Hydroxylase Screening and Gene Cloning." Applied and Environmental Microbiology 65, no. 9 (1999): 4028–31. http://dx.doi.org/10.1128/aem.65.9.4028-4031.1999.

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ABSTRACT Microbial proline 4-hydroxylases, which hydroxylate freel-proline totrans-4-hydroxy-l-proline, were screened in order to establish an industrial system for biotransformation of l-proline totrans-4-hydroxy-l-proline. Enzyme activities were detected in eight strains, including strains ofDactylosporangium spp. and Amycolatopsis spp. The Dactylosporangium sp. strain RH1 enzyme was partially purified 3,300-fold and was estimated to be a monomer polypeptide with an apparent molecular mass of 31 kDa by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. Degenerate primers based on the

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19

Mandal, Gour, Shifali Choudhary, Steven Kelley, and Shyam Sathyamoorthi. "Stereoselective Preparation of (4S)-1-Methyl-4-propyl-L-proline Commencing from (cis)-4-Hydroxy-L-proline." Molbank 2025, no. 2 (2025): M2003. https://doi.org/10.3390/m2003.

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We present a recipe for the stereoselective conversion of commercial (cis)-4-hydroxy-L-proline into (4S)-1-methyl-4-propyl-L-proline, an analog of the amino acid fragment found in the clinically used antibacterial antibiotic lincomycin. The single-crystal X-ray diffraction analysis of the final target’s hydrochloride salt confirms its identity and absolute stereochemistry.

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20

Kumar, K. S. Ajish, та Subrata Chattopadhyay. "d-Glucose based syntheses of β-hydroxy derivatives of l-glutamic acid, l-glutamine, l-proline and a dihydroxy pyrrolidine alkaloid". RSC Advances 5, № 25 (2015): 19455–64. http://dx.doi.org/10.1039/c5ra01340b.

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21

Jones, G. P., L. G. Paleg, Y. Waisel, A. Solomon, S. Beer, and E. R. T. Tiekink. "trans-3-Hydroxy-N-methyl-L-proline Hydrochloride." Acta Crystallographica Section C Crystal Structure Communications 51, no. 2 (1995): 287–89. http://dx.doi.org/10.1107/s0108270194009431.

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22

Sapkal, Anjali, Rakesh Kumar, and Abhijeet Purude. "Microwave induced synthesis of 4-hydroxy-3-methyl-7, 8-dihydroquinoline-5(6H)-one using proline catalyst." World Journal of Biology Pharmacy and Health Sciences 17, no. 1 (2024): 114–16. https://doi.org/10.5281/zenodo.11244964.

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In the present investigation synthesis of 4-hydroxy-3-methyl-7,8-dihydroquinolin-5(6H)-one was successfully demonstrated from cyclohexane-1,3-dione using microwave heating using proline catalyst. The synthesis of Hexa-Hydro-Quinolone derivatives, carried out by sequential in situ, Michael Addition, Cyclisation, and Aromatization. A new protocol for one step synthesis of 4-hydroxy-3-methyl-7,8-dihydroquinolin-5(6H)-one was successfully demonstrated from cyclohexane-1,3-dione with 98% yield.

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23

Lyda, Brent R., Gregory P. Leary, Jill Farnsworth, et al. "Discovery and Synthesis of Hydroxy-l-Proline Blockers of the Neutral Amino Acid Transporters SLC1A4 (ASCT1) and SLC1A5 (ASCT2)." Molecules 29, no. 10 (2024): 2330. http://dx.doi.org/10.3390/molecules29102330.

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As a conformationally restricted amino acid, hydroxy-l-proline is a versatile scaffold for the synthesis of diverse multi-functionalized pyrrolidines for probing the ligand binding sites of biological targets. With the goal to develop new inhibitors of the widely expressed amino acid transporters SLC1A4 and SLC1A5 (also known as ASCT1 and ASCT2), we synthesized and functionally screened synthetic hydroxy-l-proline derivatives using electrophysiological and radiolabeled uptake methods against amino acid transporters from the SLC1, SLC7, and SLC38 solute carrier families. We have discovered a no

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24

Hanson, R. L., R. M. Johnston, S. L. Goldberg, W. L. Parker та R. N. Patel. "Enzymatic preparation of 5-hydroxy-l-proline, N-Cbz-5-hydroxy-l-proline, and N-boc-5-hydroxy-l-proline from (α-N-protected)-l-ornithine using a transaminase or an amine oxidase". Enzyme and Microbial Technology 48, № 6-7 (2011): 445–53. http://dx.doi.org/10.1016/j.enzmictec.2011.03.007.

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25

SHIBASAKI, Takeshi, Hideo MORI, and Akio OZAKI. "Enzymatic Production oftrans-4-Hydroxy-L-proline by Regio- and Stereospecific Hydroxylation ofL-Proline." Bioscience, Biotechnology, and Biochemistry 64, no. 4 (2000): 746–50. http://dx.doi.org/10.1271/bbb.64.746.

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26

Lee, Ren-Shen, and Jen-Ming Yang. "Pseudopoly(amino acid)s: Copolymerization oftrans-4-hydroxy-L-proline and ?-hydroxy acids." Journal of Polymer Science Part A: Polymer Chemistry 39, no. 5 (2001): 724–31. http://dx.doi.org/10.1002/1099-0518(20010301)39:5<724::aid-pola1044>3.0.co;2-n.

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27

Sinhababu, Amalendu. "Modified Ninhydrin reagent for the detection of amino acids on TLC plates." Journal of Applied and Natural Science 5, no. 1 (2013): 125–27. http://dx.doi.org/10.31018/jans.v5i1.292.

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Ninhydrin is the most well known spray reagent for identification of amino acids due to its high sensitivity. But, it produces same purple/violet color with all amino acids, except proline and hydroxy proline. A new spray reagent, para bromobenzoic acid has been introduced here which produces distinguishable colors with the amino acids with moderately high sensitivity (0.01-1.0) μg. A probable mechanism for such color formation has also been proposed.

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28

Musetti, R., A. Vecchione, L. Stringher, et al. "Inhibition of Sporulation and Ultrastructural Alterations of Grapevine Downy Mildew by the Endophytic Fungus Alternaria alternata." Phytopathology® 96, no. 7 (2006): 689–98. http://dx.doi.org/10.1094/phyto-96-0689.

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One hundred twenty-six endophytic microorganisms isolated from grapevine leaves showing anomalous symptoms of downy mildew were tested on grapevine leaf disks as biocontrol agents against Plasmopara viticola. Among the 126 microorganisms, only five fungal isolates completely inhibited the sporulation of P. viticola; all of them were identified as Alternaria alternata. Ultrastructural analyses were carried out by transmission electron microscopy to observe cellular interactions between P. viticola and A. alternata in the grapevine leaf tissue. Cytological observations indicated that, even witho

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29

Poljakoff-Mayber, A., DE Symon, GP Jones, BP Naidu, and LG Paleg. "Nitrogenous Compatible Solutes in Native South Australian Plants." Functional Plant Biology 14, no. 3 (1987): 341. http://dx.doi.org/10.1071/pp9870341.

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Australian native flora was examined with nuclear magnetic resonance (n.m.r.) techniques for its content of nitrogenous compatible solutes. Plants were sampled from four habitats: two arid, one subhumid, and one saline estuarine marsh. Eight and two of the 15 plants in the subhumid area accumulated proline and glycinebetaine, respectively, whereas many of the plants in the two arid habitats accumulated these solutes. With only two exceptions plants in the saline marsh could be described as either proline accumulators (six species) or glycinebetaine accumulators (eight species). Attempts to cor

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30

Brandenburg, Fabian, Stephan Klähn, Andreas Schmid, and Jens O. Krömer. "Produktion von Aminosäurederivaten in Cyanobakterien." BIOspektrum 28, no. 3 (2022): 341–43. http://dx.doi.org/10.1007/s12268-022-1756-z.

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AbstractAs photolithoautotrophs, cyanobacteria are key to a future photobiotechnology. We studied the capacity of Synechocystis sp. PCC 6803 to produce trans-4-hydroxy-L-proline, a valuable chiral synthon using oxygenic photosynthesis and a recombinant L-proline-4-hydroxylase. At scale, such a process would use comparable area of land to a heterotrophic one if the photosynthesis of sugar is also considered. Phototrophs offer a huge potential for higher production rates and product titers.

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Pilkington, Rowan L., Madeleine A. Dallaston, G. Paul Savage, Craig M. Williams, and Anastasios Polyzos. "Enone-promoted decarboxylation of trans-4-hydroxy-l-proline in flow: a side-by-side comparison to batch." Reaction Chemistry & Engineering 6, no. 3 (2021): 486–93. http://dx.doi.org/10.1039/d0re00442a.

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An efficient and scalable enone-promoted method for the decarboxylation of trans-4-hydroxy-proline has been developed in flow to provide access to (R)-pyrrolidin-3-ol hydrochloride using biomass-derived isophorone.

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32

Hara, Toshiaki J., Torarinn Sveinsson, Robert E. Evans, and Dorthy A. Klaprat. "Morphological and functional characteristics of the olfactory and gustatory organs of three Salvelinus species." Canadian Journal of Zoology 71, no. 2 (1993): 414–23. http://dx.doi.org/10.1139/z93-058.

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Morphological features and response characteristics of the olfactory and gustatory organs were studied in three char species, Arctic char (Salvelinus alpinus), brook char (S. fontinalis), and lake char (S. namaycush). In brook, lake, and Norwegian-stock Arctic chars the olfactory rosette consisted of 12–16 primary olfactory lamellae radiating from the rostro-caudally oriented raphe, with the secondary folding typical of salmonids. Nauyuk-stock Arctic char had fewer (7–9) olfactory lamellae without secondary folding. Electro-olfactogram response characteristics to L-cysteine, L-arginine, and L-

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33

Gharibi, Hassan, Alexey L. Chernobrovkin, Gunilla Eriksson, et al. "Abnormal (Hydroxy)proline Deuterium Content Redefines Hydrogen Chemical Mass." Journal of the American Chemical Society 144, no. 6 (2022): 2484–87. http://dx.doi.org/10.1021/jacs.1c12512.

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34

Serizawa, Nobufusa, Tatsuji Matsuoka, Tsuyoshi Hosoya, and Kouhei Furuya. "Fermentative Production oftrans-4-Hydroxy-L-proline byClonostachys cylindrospora." Bioscience, Biotechnology, and Biochemistry 59, no. 3 (1995): 555–57. http://dx.doi.org/10.1271/bbb.59.555.

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35

Sinha, Surajit, Santosh Tilve, and Srinivasan Chandrasekaran. "A convenient synthesis of trans -3-hydroxy-L-proline." Arkivoc 2005, no. 11 (2005): 209–17. http://dx.doi.org/10.3998/ark.5550190.0006.b18.

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36

Chakraborty, T. K., P. Srinivasu, R. Vengal Rao, S. Kiran Kumar, and A. C. Kunwar. "Conformational Studies of Peptides Containingcis-3-Hydroxy-d-proline." Journal of Organic Chemistry 69, no. 21 (2004): 7399–402. http://dx.doi.org/10.1021/jo048893r.

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37

Sharifi, Azam, Sakineh Mashjoor, Behzad Sharif Makhmalzadeh, Layasadat Khorsandi, and Mohammad Reza Shushizadeh. "Baicalin-loaded proline and hydroxy proline functionalized chitosan derivative nanofiber composite as burning wound dressings." Applied Materials Today 41 (December 2024): 102519. http://dx.doi.org/10.1016/j.apmt.2024.102519.

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38

Burger, Klaus, Martin Rudolph, and Susanna Fehn. "Synthesis of 4-Oxo-L-proline andcis-4-Hydroxy-L-proline Derivatives fromL-Aspartic Acid." Angewandte Chemie International Edition in English 32, no. 2 (1993): 285–87. http://dx.doi.org/10.1002/anie.199302851.

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39

Mori, S., H. Hasegawa, R. Che, H. Nakanishi, and M. Murakami. "Free proline contents in two different groups of rice mutants resistant to hydroxy-L-proline." Theoretical and Applied Genetics 77, no. 1 (1989): 44–48. http://dx.doi.org/10.1007/bf00292314.

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Eteme, Olivier Ndogo, Nkwengoua Tchouboun Zondegoumba Ernestine, Soh Desire, Oladimeji Taiwo Babatunde, and Barthelemy Nyasse. "Inhibition of prolyl oligopeptidase by flavonoids isolated from the roots of Allexis obanensis (Baker f.) Melch." BIOMED natural and applied science 1, no. 2 (2021): 39–44. http://dx.doi.org/10.53858/bnas01023944.

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Background: Prolyl oligopeptidase is a cytosolic serine peptidase that hydrolyzes peptides containing proline at the carboxy terminus of proline residues. It has been associated with several neurodegenerative diseases. Therefore, it is a target in the management of these disease conditions. Methods: Allexis obanensis was taken through cold extraction, subjected to column chromatography and flavonoids isolated via high-performance liquid chromatographic technique. The flavonoids obtained were investigated for their in vitro prolyl oligopeptidase inhibitory activity. Results: The flavonoids isol

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Sapkal Anjali, Kumar Rakesh, and Purude Abhijeet. "Microwave induced synthesis of 4-hydroxy-3-methyl-7, 8-dihydroquinoline-5(6H)-one using proline catalyst." World Journal of Biology Pharmacy and Health Sciences 17, no. 1 (2024): 114–16. http://dx.doi.org/10.30574/wjbphs.2024.17.1.0018.

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In the present investigation synthesis of 4-hydroxy-3-methyl-7,8-dihydroquinolin-5(6H)-one was successfully demonstrated from cyclohexane-1,3-dione using microwave heating using proline catalyst. The synthesis of Hexa-Hydro-Quinolone derivatives, carried out by sequential in situ, Michael Addition, Cyclisation, and Aromatization. A new protocol for one step synthesis of 4-hydroxy-3-methyl-7,8-dihydroquinolin-5(6H)-one was successfully demonstrated from cyclohexane-1,3-dione with 98% yield.

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Klein, Christian, and Wolfgang Hüttel. "Tertiary alcohol preferred: Hydroxylation oftrans-3-methyl-L-proline with proline hydroxylases." Beilstein Journal of Organic Chemistry 7 (December 5, 2011): 1643–47. http://dx.doi.org/10.3762/bjoc.7.193.

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The enzymatic synthesis of tertiary alcohols by the stereospecific oxidation of tertiary alkyl centers is a most-straightforward but challenging approach, since these positions are sterically hindered. In contrast to P450-monooxygenases, there is little known about the potential of non-heme iron(II) oxygenases to catalyze such reactions. We have studied the hydroxylation oftrans-3-methyl-L-proline with the α-ketoglutarate (α-KG) dependent oxygenases,cis-3-proline hydroxylase type II andcis-4-proline hydroxylase (cis-P3H_II andcis-P4H). Withcis-P3H_II, the tertiary alcohol product (3R)-3-hydrox

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Mukai, Yuri, Keitaro Machino, Kenji Etchuya, Hirotaka Tanaka, and Takanori Sasaki. "CORRELATION BETWEEN PROLINE-PROLINE/HYDROXY-PROLINE IN COLLAGEN PROTEINS AND THE MOISTURE CONTENT OF THE STRATUM CORNEUM AFTER ORAL INGESTION." International Journal on Applied Bio-Engineering 7, no. 1 (2013): 71–75. http://dx.doi.org/10.18000/ijabeg.10113.

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Kostritskiy, Alexander Yu, Marina G. Nakonechnikova, Olga V. Fedotova, and Nina V. Pchelintseva. "Synthesis and Heterocyclization of 4-Hydroxy-3 - ((2-hydroxy-4,4-dimethyl-6-oxocyclohex1-en-1-yl) (aryl) methyl) -2H-chromen-2-ones." Izvestiya of Saratov University. New Series. Series: Chemistry. Biology. Ecology 20, no. 4 (2020): 362–71. http://dx.doi.org/10.18500/1816-9775-2020-20-4-362-371.

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The possibility of obtaining asymmetric 1,5-diketones based on 4-hydroxy-2H-chromen-2-one and dimedone by three-component condensation in the presence of L-proline as a catalyst is shown. As a result, a series of 4-hydroxy3 - ((2-hydroxy-4,4-dimethyl-6-oxocyclohex1-en-1-yl) (aryl) methyl) -2H-chromen-2-ones was obtained with a yield of 25 up to 73%. The study revealed that the highest yield was observed for compounds containing fragments of ortho-substituted aldehydes capable of forming a hydrogen bond. For meta- and para-substituted – the lowest yield was observed. In the case of ortho-substi

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Karamthulla, Shaik, Suman Pal, Tasneem Parvin, and Lokman H. Choudhury. "L-proline catalyzed multicomponent reactions: facile access to 2H-benzo[g]pyrazolo[3,4-b]quinoline-5,10(4H,11H)-dione derivatives." RSC Adv. 4, no. 29 (2014): 15319–24. http://dx.doi.org/10.1039/c4ra00876f.

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Three component reaction of 2-hydroxy 1,4-naphthoquinones, aldehydes, and aminopyrazoles in the presence of a catalytic amount ofl-proline has been described for the synthesis of a series of 2H-benzo[g]pyrazolo[3,4-b]quinoline-5,10(4H,11H)-dione derivatives.

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KURODA, HISAYA, SHIGERU KUBO, NAOYOSHI CHINO, TERUTOSHI KIMURA, and SHUMPEI SAKAKIBARA. "Unexpected racemization of proline or hydroxy-proline phenacyl ester during coupling reactions with Boc-amino acids." International Journal of Peptide and Protein Research 40, no. 2 (2009): 114–18. http://dx.doi.org/10.1111/j.1399-3011.1992.tb01458.x.

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Neacsu, Ana, Daniela Gheorghe, Cornelia Marinescu, Elena Stancu, Victorita Tecuceanu, and Crinu Ciuculescu. "The effect of gamma rays upon L-proline and 4-hydroxy-L-proline. A thermochemical study." Radiation Physics and Chemistry 156 (March 2019): 115–27. http://dx.doi.org/10.1016/j.radphyschem.2018.11.004.

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Hara, Ryotaro, and Kuniki Kino. "Characterization of novel 2-oxoglutarate dependent dioxygenases converting l-proline to cis-4-hydroxy-l-proline." Biochemical and Biophysical Research Communications 379, no. 4 (2009): 882–86. http://dx.doi.org/10.1016/j.bbrc.2008.12.158.

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Dar, Ajaz A., Sameer Hussain, Debasish Dutta, Parameswar K. Iyer, and Abu T. Khan. "One-pot synthesis of functionalized 4-hydroxy-3-thiomethylcoumarins: detection and discrimination of Co2+ and Ni2+ ions." RSC Advances 5, no. 71 (2015): 57749–56. http://dx.doi.org/10.1039/c5ra09152g.

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A variety of 4-hydroxy-3-thiomethylcoumarin derivatives were synthesized via a one-pot three-component reaction catalysed by l-proline at room temperature. One of the derivative was used as fluorescence probe to monitor and distinguish Co<sup>2+</sup> and Ni<sup>2+</sup>.

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Bashir, Abdallah, Tamara Hoffmann, Bettina Kempf, Xiulan Xie, Sander H. J. Smits, and Erhard Bremer. "Plant-derived compatible solutes proline betaine and betonicine confer enhanced osmotic and temperature stress tolerance to Bacillus subtilis." Microbiology 160, no. 10 (2014): 2283–94. http://dx.doi.org/10.1099/mic.0.079665-0.

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l-Proline is a widely used compatible solute and is employed by Bacillus subtilis, through both synthesis and uptake, as an osmostress protectant. Here, we assessed the stress-protective potential of the plant-derived l-proline derivatives N-methyl-l-proline, l-proline betaine (stachydrine), trans-4-l-hydroxproline and trans-4-hydroxy-l-proline betaine (betonicine) for cells challenged by high salinity or extremes in growth temperature. l-Proline betaine and betonicine conferred salt stress protection, but trans-4-l-hydroxyproline and N-methyl-l-proline was unable to do so. Except for l-prolin

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