Academic literature on the topic 'Hydroxylated biphenyls'

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Journal articles on the topic "Hydroxylated biphenyls"

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Higson, F. K., and D. D. Focht. "Bacterial metabolism of hydroxylated biphenyls." Applied and Environmental Microbiology 55, no. 4 (1989): 946–52. http://dx.doi.org/10.1128/aem.55.4.946-952.1989.

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Satoh, Andrea Y., James E. Trosko, and Susan J. Masten. "Epigenetic Toxicity of Hydroxylated Biphenyls and Hydroxylated Polychlorinated Biphenyls on Normal Rat Liver Epithelial Cells." Environmental Science & Technology 37, no. 12 (2003): 2727–33. http://dx.doi.org/10.1021/es021041t.

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Tampal, Nilufer, Hans-Joachim Lehmler, Parvaneh Espandiari, Tina Malmberg, and Larry W. Robertson. "Glucuronidation of Hydroxylated Polychlorinated Biphenyls (PCBs)." Chemical Research in Toxicology 15, no. 10 (2002): 1259–66. http://dx.doi.org/10.1021/tx0200212.

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Hall, Emma A., Md Raihan Sarkar, and Stephen G. Bell. "The selective oxidation of substituted aromatic hydrocarbons and the observation of uncoupling via redox cycling during naphthalene oxidation by the CYP101B1 system." Catalysis Science & Technology 7, no. 7 (2017): 1537–48. http://dx.doi.org/10.1039/c7cy00088j.

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Pham, Thi Thanh My, Mohammad Sondossi, and Michel Sylvestre. "Metabolism of Doublypara-Substituted Hydroxychlorobiphenyls by Bacterial Biphenyl Dioxygenases." Applied and Environmental Microbiology 81, no. 14 (2015): 4860–72. http://dx.doi.org/10.1128/aem.00786-15.

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ABSTRACTIn this work, we examined the profile of metabolites produced from the doublypara-substituted biphenyl analogs 4,4′-dihydroxybiphenyl, 4-hydroxy-4′-chlorobiphenyl, 3-hydroxy-4,4′-dichlorobiphenyl, and 3,3′-dihydroxy-4,4′-chlorobiphenyl by biphenyl-inducedPandoraea pnomenusaB356 and by its biphenyl dioxygenase (BPDO). 4-Hydroxy-4′-chlorobiphenyl was hydroxylated principally through a 2,3-dioxygenation of the hydroxylated ring to generate 2,3-dihydro-2,3,4-trihydroxy-4′-chlorobiphenyl and 3,4-dihydroxy-4′-chlorobiphenyl after the removal of water. The former was further oxidized by the b
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Turner, Kendrick, Smita Joel, Jessika Feliciano, et al. "Transcriptional regulatory proteins as biosensing tools." Chemical Communications 53, no. 51 (2017): 6820–23. http://dx.doi.org/10.1039/c6cc09512g.

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We have developed sensing systems employing different classes of transcriptional regulatory proteins genetically and chemically modified to incorporate a fluorescent reporter molecule for detection of arsenic, hydroxylated polychlorinated biphenyls (OH-PCBs), and cyclic AMP (cAMP).
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Shi, Yong Fu, Zhou Luo Ou, You Qiong Cai, et al. "Effects of Polychlorinated Biphenyl (PCB101) and its Hydroxylated Metabolites on Proliferation of MCF-7 Human Breast Cancer Cells." Advanced Materials Research 781-784 (September 2013): 927–31. http://dx.doi.org/10.4028/www.scientific.net/amr.781-784.927.

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Polychlorinated biphenyls and their hydroxylated metabolites become more and more concerned for their endocrine disruption. At the presented study, experiment was designed to obtain the disruption effect of PCB101 and its hydroxylated metabolites . The proliferation of MCF-7 human breast cancer cells was detected at different exposed concentration and time period. MCF-7 cells were cultured with the concentration of PCB101 and twor of its hydroxylated metabolites at 5×10-95×10-85×10-75×10-6mol/L. And the concentrations of 17β-Estradiol (E2) were2×10-92×10-82×10-72×10-6mol/L respectively. And th
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SINJARI, T., E. KLASSON-WEHLER, L. HOVANDER, and P. O. DARNERUD. "Hydroxylated polychlorinated biphenyls : distribution in the pregnant mouse." Xenobiotica 28, no. 1 (1998): 31–40. http://dx.doi.org/10.1080/004982598239731.

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Wiegel, Juergen, Xiaoming Zhang, and Qingzhong Wu. "Anaerobic Dehalogenation of Hydroxylated Polychlorinated Biphenyls by Desulfitobacterium dehalogenans." Applied and Environmental Microbiology 65, no. 5 (1999): 2217–21. http://dx.doi.org/10.1128/aem.65.5.2217-2221.1999.

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ABSTRACT Ten years after reports on the existence of anaerobic dehalogenation of polychlorinated biphenyls (PCBs) in sediment slurries, we report here on the rapid reductive dehalogenation ofpara-hydroxylated PCBs (HO-PCBs), the excreted main metabolites of PCB in mammals, which can exhibit estrogenic and antiestrogenic activities in humans. The anaerobic bacteriumDesulfitobacterium dehalogenans completely dehalogenates all flanking chlorines (chlorines in ortho position to thepara-hydroxyl group) from congeners such as 3,3′,5,5′-tetrachloro-4,4′-dihydroxybiphenyl.
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Kostić, Kristina, Jasmina Brborić, Giovanna Delogu, et al. "Antioxidant Activity of Natural Phenols and Derived Hydroxylated Biphenyls." Molecules 28, no. 6 (2023): 2646. http://dx.doi.org/10.3390/molecules28062646.

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A comparative in vitro study of the antioxidant potential of natural phenols (zingerone, curcumin, raspberry ketone, magnolol) and their synthesized derivatives was performed. The antioxidant efficiency was evaluated in blood serum obtained from healthy individuals, by means of spectrophotometry, before and after the addition of pro-oxidant tert-butyl hydroperoxide (TBH). Moreover, the antioxidant effect of an equimolar mixture of curcumin and zingerone was investigated. Interpretation of our results reveals that in the blood serum of healthy individuals curcumin (C1), raspberry ketone (RK1),
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Dissertations / Theses on the topic "Hydroxylated biphenyls"

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Bhalla, Renu. "BIOLOGICAL EFFECTS OF HYDROXYLATED METABOLITES OF POLYCHLORINATED BIPHENYLS." Master's thesis, Temple University Libraries, 2011. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/120626.

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Civil Engineering<br>M.S.E.<br>Polychlorinated biphenyls (PCBs) are widespread persistent organic pollutants. The metabolism of PCBs by various organisms involves many steps that can lead to the formation of a wide range of metabolites. These metabolites frequently exhibit a toxicity and biodegradability different than the parent compounds. There is currently little information available about the biological effects of PCB hydroxylated metabolites that can be generated by various organisms and potentially released into the environment. The objective of the present research is to compare the to
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Subramanian, Srishty. "MOLECULAR METHODS FOR ASSESSING THE RESPONSE OF ARABIDOPSIS THALIANA PLANTS TO POLYCHLORINATED BIPHENYLS AND HYDROXYLATED POLYCHLORINATED BIPHENYLS." Diss., Temple University Libraries, 2018. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/535049.

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Environmental Engineering<br>Ph.D.<br>Polychlorinated biphenyls (PCBs) are a class of persistent organic contaminants that are ubiquitous and persistent in the environment. In the environment, PCBs have been shown to undergo various degradation processes and generate hydroxylated metabolites known as hydroxylated polychlorinated biphenyls (OH-PCBs). There is a growing scientific interest in studying OH-PCBs as they are being increasingly detected in biotic and abiotic samples. Due to their widespread presence in the air, water, and soil, as well as their ability to bioaccumulate in living orga
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Geng, Shen. "INVESTIGATION OF THE TOXICITY AND EFFLUX OF POLYCHLORINATED BIPHENYLS AND HYDROXYLATED POLYCHLORINATED BIPHENYLS IN ESCHERICHIA COLI." UKnowledge, 2011. http://uknowledge.uky.edu/gradschool_theses/133.

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Polychlorinated biphenyls (PCBs) are persistent organic pollutants. Due to their properties, PCBs accumulate in the food-chain and post a threat to the health of human beings and wildlife. Hydroxylated PCBs (OH-PCBs) are oxidative metabolites of PCBs and are more hydrophilic than their parent PCBs. One of the best approaches to break down these contaminants is through bioremediation, which is an environmental friendly process that uses microorganisms to restore natural environment. Towards this goal, we have investigated the toxicity and accumulation of PCBs and OH-PCBs in a Gram-negative bact
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Ekuase, Edugie Jennifer. "Structure-activity relationships for interactions of hydroxylated polychlorinated biphenyls with human hydroxysteroid sulfotransferase hSULT2A1." Diss., University of Iowa, 2011. https://ir.uiowa.edu/etd/959.

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Industrial chemicals known as polychlorinated biphenyls (PCBs) were widely used for decades until their production was banned worldwide due to their persistence and toxicities to humans and other animals. Upon oxidative metabolism by cytochrome P450, hydroxylated metabolites of PCBs (OHPCBs) are formed. OHPCBs have been shown to competitively displace thyroxine from transthyretin, block normal hormonal activity, and inhibit phenol or family 1 sulfotransferases (SULTs) which catalyze sulfation of thyroid hormones and estrogens. Recently, three OHPCBs were shown to also interact with hydroxyster
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Malmberg, Tina. "Identification and characterisation of hydroxylated PCB and PBDE metabolites in blood : congener specific synthesis and analysis /." Stockholm : Institutionen för miljökemi, Univ, 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-245.

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Afsarmanesh, Tehrani Rouzbeh. "AEROBIC BACTERIAL DEGRADATION OF HYDROXYLATED PCBs: POTENTIAL IMPLICATIONS FOR NATURAL ATTENUATION OF PCBs." Diss., Temple University Libraries, 2013. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/216532.

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Civil Engineering<br>Ph.D.<br>Polychlorinated biphenyls (PCBs) are toxic and persistent chemicals that have been largely dispersed into the environment. The biological and abiotic transformations of PCBs often generate hydroxylated derivatives, which have been detected in a variety of environmental samples, including animal tissues and feces, water, and sediments. Because of their toxicity and widespread dispersion in the environment, hydroxylated PCBs (OH-PCBs) are today increasingly considered as a new class of environmental contaminants. Although PCBs are known to be susceptible to microbia
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Koh, Wen Xin. "Polychlorinated biphenyls and their hydroxylated metabolites in human serum from urban and rural cohorts in the United States." Diss., University of Iowa, 2015. https://ir.uiowa.edu/etd/5793.

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In this dissertation, concentrations of 209 polychlorinated biphenyl (PCB) congeners and 64 hydroxylated PCB (OH-PCB) congeners were determined in 97 adolescents and 86 mothers living in East Chicago, Indiana and Columbus Junction, Iowa. Sera of the participants were collected between April 2010 and March 2011. PCBs and OH-PCBs in human sera were extracted, separated and quantified using gas chromatography tandem mass spectrometry (GC-MS/MS). A quality control protocol was established to ensure data quality during extraction and analysis processes and to affirm the data were representative, ac
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Uwimana, Eric. "Probing the PCB metabolome: metabolism of chiral and non-chiral polychlorinated biphenyls to chiral hydroxylated metabolites in humans and rats." Diss., University of Iowa, 2018. https://ir.uiowa.edu/etd/6657.

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Polychlorinated biphenyls (PCBs) continue to pose a health concern because of their predominance in the diet and air as well as in environmental samples and humans. PCB congeners with 3 or 4 chlorine substituents in ortho position have been associated with neurodevelopmental disorders. Hydroxylated metabolites (OH-PCBs) of these PCBs are also potentially toxic to the developing brain. Metabolism studies have mainly focused on animal models. However, preliminary data from this dissertation work have revealed PCB metabolism differences between laboratory animal models and humans in terms of meta
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Marek, Rachel Frances. "Polychlorinated biphenyls (PCBs) and hydroxylated PCBs in serum from U.S. children and their mothers and in sediment from a Lake Michigan waterway." Diss., University of Iowa, 2013. https://ir.uiowa.edu/etd/1878.

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In this dissertation I compare concentrations of polychlorinated biphenyls (PCBs) and hydroxylated PCBs (OH-PCB) in serum of children and their mothers from urban and rural U.S. communities, determine the variability of these concentrations from year to year, and report the detection of OH-PCBs in sediment from a Lake Michigan waterway and original commercial Aroclors. I developed extraction and analytical methods for the analysis of PCBs and OH-PCBs in 377 human serum samples and 20 sediment samples. I also developed a quality assurance protocol and analyzed more than 300 quality control samp
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Rodriguez, Eric Alberto. "Hydroxylated and sulfated metabolites of lower chlorinated PCBs bind with high affinity to human serum albumin and exhibit selective toxicity to neuronal cells." Diss., University of Iowa, 2016. https://ir.uiowa.edu/etd/3175.

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Polychlorinated biphenyls (PCBs) are a class of persistent organic pollutants that have been associated with a myriad of negative human health effects. These man-made compounds were used throughout most of the 20th century and although their intentional production has since been banned and their use limited to closed systems, their prevalence in the environment remains a factor in disease states for exposed populations. The worldwide levels of PCBs has been declining, however, there is evidence for renewed sources of these compounds. The presence of PCBs with lower numbers of chlorine atoms (L
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Conference papers on the topic "Hydroxylated biphenyls"

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Shi, Yong-Fu, Dong-Mei Huang, Youqiong Cai, Yuan Wang, and Hong Lin. "Silylation Derivatization for the Detection of Hydroxylated Polychlorinated Bipheny in Aquatic Products by GC/MS." In 2009 3rd International Conference on Bioinformatics and Biomedical Engineering (iCBBE). IEEE, 2009. http://dx.doi.org/10.1109/icbbe.2009.5163385.

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