Journal articles: 'Hydroxypropyl starch phosphate'

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Tian, Shuangqi, Yimei Chen, Zhicheng Chen, Yingqi Yang, and Yanbo Wang. "Preparation and Characteristics of Starch Esters and Its Effects on Dough Physicochemical Properties." Journal of Food Quality 2018 (November 12, 2018): 1–7. http://dx.doi.org/10.1155/2018/1395978.

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As a recyclable natural material, starch is an important raw material in food and other fields. The native starch by esterification could improve the performance of the original starch and expand its range of application. This article reviews the preparation process of acetylated distarch adipate, starch sodium octenylsuccinate, starch acetate, hydroxypropyl starch, and starch phosphate and research into the influence of starch esters on dough. At the same time, it forecasts the trend of starch esters and application prospect in the future research.

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Wang, Wentao, Hui Zhang, Yangyong Dai, Hanxue Hou, and Haizhou Dong. "Effects of low poly(vinyl alcohol) content on properties of biodegradable blowing films based on two modified starches." Journal of Thermoplastic Composite Materials 30, no. 7 (October 28, 2015): 1017–30. http://dx.doi.org/10.1177/0892705715614080.

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Biodegradable films from hydroxypropyl distarch phosphate (HPDSP)/poly(vinyl alcohol) (PVA) and cationic starch/PVA blends were obtained by extrusion blowing at ratios of 100:0, 95:5, 90:10, 85:15, and 80:20. The morphology, X-ray patterns, transparency, mechanical properties, thermal properties, and water vapor permeability (WVP) of the films were measured and compared. Scanning electron microscopic micrographs of the films showed continuous matrix texture as well as better compatibility between modified starches and PVA. X-Ray diffraction indicated the formation of ordered crystalline structures in the films during extrusion blowing. The addition of PVA to modified starches significantly increased their tensile strength (TS, 3.92 MPa) while decreasing their water vapor permeability (WVP, 3.23 × 10−10 g m−1 s−1 Pa−1). The starch/PVA composite films did not show phase separation.

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Til, H. P., V. J. Feron, H. R. Immel, and W. F. Vogel. "Chronic (89-week) feeding study with hydroxypropyl distarch phosphate, starch acetate, lactose and sodium alginate in mice." Food and Chemical Toxicology 24, no. 8 (August 1986): 825–34. http://dx.doi.org/10.1016/0278-6915(86)90072-4.

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Vidrih, R., E. Zlatić, and J. Hribar. "Release of Strawberry Aroma Compounds by Different Starch-Aroma Systems." Czech Journal of Food Sciences 27, Special Issue 1 (June 24, 2009): S58—S61. http://dx.doi.org/10.17221/912-cjfs.

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In the food industry, the addition of flavours is used to reinforce the aroma profile of different goods. However, interactions between starch and aroma compounds can occur, and this can impact upon aroma release and perception. In the present study, we have investigated the influence of starch type on aroma release from starch-aroma systems. The food model system used was composed of an aqueous starch dispersion (1 g dry starch/100 g dispersion) and 10 aroma compounds (ethyl butanoate, ethyl 2-methylbutanoate, ethyl 3-methylbutanoate, ethyl pentanoate, methyl hexanoate, ethyl hexanoate, methyl ethyl propanoate, hexyl acetate, 3-hexenol, and phenyl methyl acetate). Different commercially available starches were used: Amilogels P, K, PDP, G, MVK, HP, OK and HPW, and carrageenan (Amilogel CAR) and guar gum (Amilogel GG). Aroma release from these starch-aroma systems into the gas phase above food (headspace) were monitored by GC-MS analysis with a solid-phase micro-extraction technique. The smell of the starch-aroma system was also evaluated sensorially by a trained panel. The release of aroma compounds from the different starch-aroma systems was statistically significant (<I>P</I> < 0.0001) for all of the aroma compounds, with the exception of ethyl pentanoate. A correlation between the concentration of individual aroma compounds in the headspace and the sensory evaluation (smell) was seen. Starch-aroma systems comprising corn starch (Amilogel G), physically modified starches that are soluble in cold water (Amilogels K, PDP), and hydroxypropyl distarch phosphate (Amilogels HP) had sensorially superior smells compared to the other types of starches tested. At the same time, the headspace GC-MS analyses showed ethyl butanoate, ethyl 2-methylbutanoate, ethyl 3-methylbutanoate and ethyl pentanoate to be at the highest concentrations, which are all typical aroma compounds of strawberry fruit, and which also have low perception thresholds. Dextrin-roasted starch, guar gum and carrageenan provided the lowest sensory scores, although in contrast, they more strongly retained these aroma compounds.

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Shimotoyodome, Akira, Junko Suzuki, Yoji Kameo, and Tadashi Hase. "Dietary supplementation with hydroxypropyl-distarch phosphate from waxy maize starch increases resting energy expenditure by lowering the postprandial glucose-dependent insulinotropic polypeptide response in human subjects." British Journal of Nutrition 106, no. 1 (February 22, 2011): 96–104. http://dx.doi.org/10.1017/s0007114510005854.

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The aim of the present study was to investigate the effects of hydroxypropyl-distarch phosphate (HDP) supplementation on postprandial energy metabolism and glucose-dependent insulinotropic polypeptide (GIP) in human subjects. A total of ten healthy male subjects, with a mean BMI of 23·6 (sem 1·3) kg/m2, age 35·2 (sem 1·9) years and body weight 71·1 (sem 4·0) kg, participated in a randomised, cross-over, intervention study with two different test meals (1673·6 kJ) containing either waxy maize starch or HDP from waxy maize starch (degree of substitution 0·154, P content 0·004 %). Resting energy expenditure (REE) and blood concentrations of various biomarkers were measured at fasting and up to 180 min postprandially. Indirect calorimetry showed that the HDP meal caused higher REE (P < 0·05) and fat utilisation (P < 0·001) than the waxy maize starch meal. The HDP meal led to significantly lower postprandial glucose (P < 0·05), insulin (P < 0·05) and GIP (P < 0·05) responses than the waxy maize starch meal. Both postprandial REE (R − 0·576, P < 0·01) and fat utilisation (R − 0·514, P < 0·05) were negatively correlated with the postprandial GIP response, but not with the glucose and insulin responses. In conclusion, dietary supplementation with HDP lowers postprandial GIP and increases postprandial REE and fat utilisation in healthy humans. An HDP-rich diet may therefore have beneficial implications in weight management. Further studies are required to confirm the efficacy in overweight or obese subjects, and to determine the precise mechanisms.

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Qin, Yang, Wentao Wang, Hui Zhang, Yangyong Dai, Hanxue Hou, and Haizhou Dong. "Effects of Organic Modification of Montmorillonite on the Properties of Hydroxypropyl Di-Starch Phosphate Films Prepared by Extrusion Blowing." Materials 11, no. 7 (June 23, 2018): 1064. http://dx.doi.org/10.3390/ma11071064.

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Kishida, Taro, Yuka Nakai, and Kiyoshi Ebihara. "Hydroxypropyl-Distarch Phosphate from Tapioca Starch Reduces Zinc and Iron Absorption, but not Calcium and Magnesium Absorption, in Rats." Journal of Nutrition 131, no. 2 (February 1, 2001): 294–300. http://dx.doi.org/10.1093/jn/131.2.294.

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Ebihara, Kiyoshi, Yuka Nakai, and Taro Kishida. "Hydroxypropyl-Distarch Phosphate from Potato Starch Increases Fecal Output, but Does Not Reduce Zinc, Iron, Calcium, and Magnesium Absorption in Rats." Journal of Food Science 71, no. 2 (May 31, 2006): S163—S168. http://dx.doi.org/10.1111/j.1365-2621.2006.tb08920.x.

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M, Naga Sujan, Kunal K. Mehta, Amit B. Patil, and Anusha Vajhala. "Formulation, Characterisation and Evaluation of the Ethosuximide Oral Immediate Release Tablets." International Journal of Research in Pharmaceutical Sciences 11, no. 2 (April 14, 2020): 1807–13. http://dx.doi.org/10.26452/ijrps.v11i2.2084.

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The present study is aimed to formulate, characterization, and evaluate oral immediate-release tablets of Ethosuximide. It is employed as an anti-epileptic agent used in the treatment of epilepsy, in all the age groups who were≥ 1 year. The dosage form is formulated by directly compressing the blend and granulating the powder blend by wet granulation methods. The optimized formulation is achieved by the trial and error method by changing the concentration of lactose monohydrate and di-basic calcium phosphate dehydrate as diluents, sodium starch glycolate as Super-dis-integrant, rice Starch as an intra-granular binder, hydroxypropyl cellulose as binder talc as a lubricant. Evaluation parameters such as micrometric properties, disintegration time along with in-vitro drug release studies were performed for characterizing the dosage form. In-vitro drug release studies were carried out using 0.1 N HCl as dissolution media with 75 rpm and temperature of 370C ± 50C by employing USP apparatus II (Paddle type). Estimation of the % drug release of the tablet was carried out using the UV method. The prepared formulation and the marketed formulation were tested for the in-vitro drug release profile and the prepared formulation was compared with the marketed formulation. All the evaluated result was found to be within the specifications. Therefore, from the obtained evaluation results F6 trail was selected as the best formulation.

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Yang, Huaiwen, and Yuhsien Lin. "Effect of Thermal Processing on Flow Properties and Stability of Thickened Fluid Matrices Formulated by Tapioca Starch, Hydroxyl Distarch Phosphate (E-1442), and Xanthan Gum Associating Dysphagia-Friendly Potential." Polymers 13, no. 1 (January 4, 2021): 162. http://dx.doi.org/10.3390/polym13010162.

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The flow behavior of the administrated fluid matrices demands careful assessments for stability when consumed by individuals with dysphagia. In the present study, we incorporated tapioca starch (TS), hydroxypropyl distarch phosphate (HDP), and xanthan gum (XG) as thickeners into different nectars (300 ± 20 mPa.s) undergoing thermal processing and evaluated their stability. The thickened nectars presented better water holding and oil binding capacities at 25 °C than 4 °C, and the nectars with TS provided the best results for both capacities as well as the highest solubility index and swelling power (p < 0.05). All prepared nectars appeared to be shear-thinning fluids with yield stress closely fitting the power law and Casson models. XG-containing nectars presented a higher yield stress and consistency index. Matrices thickened by HDP exhibited a higher viscoelastic property compared to those thickened by TS during thermal processing. TS nectars presented viscous behavior, whereas HDP and XG nectars presented elastic behavior at 80 °C processing. The 3 min thermal processing HDP nectars remained stable and met dysphagia-friendly requirements under 4 °C storage for 28 days, regardless of the type of fluid base (distilled water, sport drink, or orange juice). The employed thickeners present adequate physicochemical properties to be potentially utilized for producing dysphagia-friendly formulations.

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Pandey, Bikash, and Arshad Bashir Khan. "ENHANCEMENT OF SOLUBILITY AND OPTIMIZATION OF ORALLY DISINTEGRATING FILMS OF ACYCLOVIR." Asian Journal of Pharmaceutical and Clinical Research 11, no. 9 (September 7, 2018): 280. http://dx.doi.org/10.22159/ajpcr.2018.v11i9.26891.

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Objective: The objective of this work was to prepare and optimize orally disintegrating films of acyclovir (ACV), which is a known antiviral agent. To enhance the solubility of ACV, solid dispersions of ACV were made.Methods: The films were prepared using a solvent casting technique. Full factorial design was utilized for the optimization of the effect of independent variables such as the amount of hydroxypropyl methylcellulose 5 cps, sodium starch glycolate, and propylene glycol on the disintegration time. Other evaluation tests such as drug release, drug content, thickness, and folding endurance of film were also conducted.Results: Compatibility studies by Fourier transform infrared showed that there was no significant interaction between the drug and excipients used. Disintegration time was found to be 43 s for the optimized batch. The in vitro release profile of formulation response disintegrating time in phosphate buffer pH 6.8 revealed that there was a significant increment in drug release of the optimized batch in comparison to the screening batches. Further, short-term accelerated stability studies carried out for 4 weeks for the optimized formulation which proved that the formulated films were stable at the accelerated conditions of temperature and humidity (40±2°C/75±5% RH).Conclusions: It was concluded that such ACV solid dispersion films could be beneficial in enhancement of dissolution and consequently the oral bioavailability of ACV.

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12

Panda, Subhranshu, C. H. Surya Kumari, and G. Puniya. "FORMULATION AND EVALUATION OF COMPRESSION COATING FLOATING TABLETS OF CARVEDILOL PHOSPHATE ONCE DAILY DOSE." International Journal of Pharmacy and Pharmaceutical Sciences 10, no. 6 (June 1, 2018): 82. http://dx.doi.org/10.22159/ijpps.2018v10i6.25367.

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Objective: The rationale for the study was to develop a once-daily dose of immediate as well as a gastro-retentive form of carvedilol phosphate by compression coating floating technique.Methods: In the presented study the core tablet was containing half the quantity of the drug formulated as floating drug delivery using different controlled release polymers blend in various proportions like ethyl cellulose, carbopol, hydroxypropyl methylcellulose (HPMC) K4, K15, and K100 by direct compression method. Outer coat layer was formulated with rest of the drug with the blend of different super disintegrants in various proportions like crospovidone, croscarmellose sodium (CCS), sodium starch glycolate (SSG) for the immediate release of the drug. Both the immediate and controlled formulation was separately formulated from sf1 to sf9 and f1 to f9 respectively. Based on the evaluation parameters finally, formulation F1 to F9 were formulated by applying compression coating floating method. These formulations were characterized for their tablet density, disintegration time, floating lag time, in vitro drug release, drug-excipients interaction and accelerated stability studies etc.Results: The result revealed formulation sf9 containing SSG of 15% was able to 97.2% of drug release within 15 min towards the achievement of immediate release. Similarly, the formulation f9 containing 0.5:0.5:4.5 ratios of ethyl cellulose, carbopol and HPMC K15 was able to 95.3% of drug release within 16h. From compressed coat tablets batches of F1 to F9, based on the dissolution data F9 was considered as an optimized formulation which was able to release 48.6% of drug release within 15 min and cumulatively controlled the release up to 96.4% for 16 h, followed zero-order kinetics and Higuchi pattern.Conclusion: The results obtained in this research work clearly indicated that the compression coating floating tablet of carvedilol phosphate was the best dosage form for the treatment of hypertension. Results of the evaluation of prepared batches indicate that the batch F9 is a promising formulation for both a quick onset of action as well as gastro-retentive dosage form to maintain the constant drug action which would improve the maximum therapeutic efficacy and patient compliance.

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Shaik, Salma, Sudhir Maddela, and Buchi N. Nalluri. "Development of Capecitabine Floating Tablet Dosage Forms for Treating Stomach Cancer." Journal of Drug Delivery and Therapeutics 10, no. 3-s (July 14, 2020): 199–205. http://dx.doi.org/10.22270/jddt.v10i3-s.4171.

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Objective: In the present research work, oral gastro retentive dosage forms (GRDFs) of capecitabine (CPC) were formulated using floating concept. Methods: GRDFs were formulated using hydroxypropyl methyl cellulose (HPMC K4M and K15M) as drug release retardant, sodium bicarbonate (NaHCO3) and calcium carbonate (CaCO3) as gas generating agents, and micro crystalline cellulose (MCC), dicalcium phosphate (DCP), spray dried lactose (SDL), and pre gelatinized starch (PGS) as fillers. The tablets were prepared by direct compression method and evaluated for various parameters. The GRDFs were also characterized by Fourier-transform infrared spectroscopy (FTIR), and differential scanning calorimetry (DSC). Results and Discussion: All the formulations were subjected for pre and post compression parameters, shows all the data within the limits. The lag times of GRDFs has decreased significantly for formulations containing calcium carbonate when compared to sodium bicarbonate as gas generating agent. In vitro drug release studies indicate that higher polymer concentration delayed the CPC release, and the sustaining effect was in the order K4M > K15M > LVCR 100. Addition of MCC, DCP, SDL, and PGS as fillers further affected the lag time and in turn the CPC release rates. Conclusion: The formulation (F9) containing 10%w/w HPMC K4M as the release retardant, microcrystalline cellulose as filler and 20%w/w CaCO3 as gas generating agent fulfilled regulatory requirements in terms of percent drug release at the end of 24h. Keywords: Capecitabine, Gastro retentive floating tablets, floating drug delivery systems, FTIR, DSC.

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"Synthesis and Evaluation of New Environment-Friendly Starch Hydroxypropyl Phosphate as Flocculant." Egyptian Journal of Chemistry 56, no. 5 (December 30, 2013): 417–33. http://dx.doi.org/10.21608/ejchem.2013.1121.

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Mortensen, Alicja, Fernando Aguilar, Riccardo Crebelli, Alessandro Di Domenico, Birgit Dusemund, Maria Jose Frutos, Pierre Galtier, et al. "Re‐evaluation of oxidised starch (E 1404), monostarch phosphate (E 1410), distarch phosphate (E 1412), phosphated distarch phosphate (E 1413), acetylated distarch phosphate (E 1414), acetylated starch (E 1420), acetylated distarch adipate (E 1422), hydroxypropyl starch (E 1440), hydroxypropyl distarch phosphate (E 1442), starch sodium octenyl succinate (E 1450), acetylated oxidised starch (E 1451) and starch aluminium octenyl succinate (E 1452) as food additives." EFSA Journal 15, no. 10 (October 2017). http://dx.doi.org/10.2903/j.efsa.2017.4911.

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Shrestha, Sangam, Preethi Sudheer, and Kavitha A.N. "Amorphous Solid Dispersion Based Oral Disintegrating Film of Ezetimibe: Development and evaluation." Drug Metabolism Letters 14 (September 1, 2020). http://dx.doi.org/10.2174/1872312814666200901182517.

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Background: Ezetimibe is a cholesterol lowering agent with an oral bioavailability of 50 % by the virtue of its poor solubility, extensive hepatic and intestinal metabolism. Objective: The study is aimed to overcome low bioavailability issues of ezetimibe by formulating an oral disintegrating film. Method: The low solubility of ezetimibe was tackled preparing solid dispersions using mannitol, β-cyclodextrin and urea. The mannitol solid dispersion assimilated oral disintegrating film was prepared and optimized using 2 3 factorial design, where concentration of film formers hydroxypropyl methyl cellulose (K5 & K15) (X1and X2) and super disintegrant, sodium starch glycolate (X3) was used as factors on the response disintegration time (Y). The films were evaluated for physical properties, time of disintegration and drug release profiles. Results and Discussions: Mannitol solid dispersion (1:2 ratio) on the basis of the superior drug content, solubility and in vitro release profile was preferred in film formation. The low crystalline nature of the solid dispersion was very evident by the absence of prominent peaks in the X Ray diffraction pattern and the reduced peak intensity of melting endotherms. The correlation coefficient (R2 ) and statistical parameter analysis of variance specifies implication of linear factors on responses, which is apparent from confidence intervals (Pvalues) less than 0.05. The in vitro release profile of all the eight formulations (F1-F8) in phosphate buffer solution pH 6.8 revealed a significant increment in comparison to ezetimibe. Conclusion: The study revealed that the formulation approach could overcome the biopharmaceutical challenge of solubility as well as low bioavailability issues of ezetimibe.

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Journal articles on the topic 'Hydroxypropyl starch phosphate'

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