Relevant bibliographies by topics / Hydroxyquinoline derivatives

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Academic literature on the topic 'Hydroxyquinoline derivatives'

Author: Grafiati
Published: 5 June 2025
Last updated: 1 August 2025

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Journal articles on the topic "Hydroxyquinoline derivatives"

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Suwanjang, Wilasinee, Supaluk Prachayasittikul, and Virapong Prachayasittikul. "Effect of 8-hydroxyquinoline and derivatives on human neuroblastoma SH-SY5Y cells under high glucose." PeerJ 4 (August 31, 2016): e2389. http://dx.doi.org/10.7717/peerj.2389.

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8-Hydroxyquinoline and derivatives exhibit multifunctional properties, including antioxidant, antineurodegenerative, anticancer, anti-inflammatory and antidiabetic activities. In biological systems, elevation of intracellular calcium can cause calpain activation, leading to cell death. Here, the effect of 8-hydroxyquinoline and derivatives (5-chloro-7-iodo-8-hydroxyquinoline or clioquinol and 8-hydroxy-5-nitroquinoline or nitroxoline) on calpain-dependent (calpain-calpastatin) pathways in human neuroblastoma (SH-SY5Y) cells was investigated. 8-Hydroxyquinoline and derivatives ameliorated high
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Csuvik, Oszkár, and István Szatmári. "Synthesis of Bioactive Aminomethylated 8-Hydroxyquinolines via the Modified Mannich Reaction." International Journal of Molecular Sciences 24, no. 9 (2023): 7915. http://dx.doi.org/10.3390/ijms24097915.

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8-hydroxyquinoline (oxine) is a widely known and frequently used chelating agent, and the pharmacological effects of the core molecule and its derivatives have been studied since the 19th century. There are several synthetic methods to modify this core. The Mannich reaction is one of the most easily implementable examples, which requires mild reaction conditions and simple chemical reagents. The three components of the Mannich reaction are a primary or secondary amine, an aldehyde and a compound having a hydrogen with pronounced activity. In the modified Mannich reaction, naphthol or a nitroge
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ZARIF, H. KHALIL, S. YANNI AMAL, A. ABDEL-HAFEZ ALI, and A. KHALAF ALI. "Synthesis and Microbial Activity of 5-Heterocyclo-8-hydroxyquinolines." Journal of Indian Chemical Society Vol. 67, Oct. 1990 (1990): 821–23. https://doi.org/10.5281/zenodo.6244154.

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Chemistry Department, Faculty of Science, Assiut University, Assiut, Egypt <em>Manuscript received 24 March 1986, revised 27 March 1990, accepted 22 August 1990</em> A new series of &nbsp;5-substituted cinnamoyl-8-hydroxyquinoline (1a-e) were prepared via the reaction of &nbsp;5-acetyl-8-hydroxyquinoline with the selected aldehydes. 5 Pyrazolino-, isooxazolino-, and/or pyrmidine-thiono 8-hydroxyquinoline (2 - 4 respectively) were obtained from the reaction of &nbsp;la-e with hydrazines, hydroxylamine and thiourea. Michael addition of active methylene compounds, e.g. malononitrile, cyanoethyl a
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Kaplaushenko, Т. М., О. І. Panasenko та Y. G. Samelyuk. "Synthesis and establishment of physico-chemical constants 2-(5-( chinoline -2-il, 2-hydroxyquinoline-4-іл)-4-R1-1,2,4-triazole-3-ілтіо) acetate acids and their esther". Farmatsevtychnyi zhurnal, № 2 (14 серпня 2018): 53–59. http://dx.doi.org/10.32352/0367-3057.2.16.04.

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The large interest in the plan of search biologically of active agents is caused by the heterocyclic system of 1,2,4-triazole, due to high biological activity, and by the low indexes of toxicness, that inherent it to the structural analogues. Today in medical practice the derivatives of 1,2,4-triazole are used as high-efficiency antioxidants, cytostatic antimycotic agent , antidepressants and others.&#x0D; Literary information testify that among connections, representatives derivative of 3-tio-1,2,4-triazole range condensed with heteryl carboxylic acid, and their derivatives, find matters with
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Xueling Zheng, Xueling Zheng. "Synthesis, Photoelectrochemical and Aggregation Properties of Two New 8-hydroxyquinoline Derivatives." Journal of the chemical society of pakistan 47, no. 1 (2025): 58. https://doi.org/10.52568/001625/jcsp/47.01.2025.

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Two new 8-hydroxyquinoline (8-HQ) derivatives, namely 5-((4-chlorobenzene) diazene) -8-hydroxyquinoline (N-HQ) and 5-((4-chlorobenzene) methylene amino) -8-hydroxyquinoline (C-HQ), were designed and synthesized. Their structures were characterized by 1H NMR, 13C NMR, FT-IR and HR-MS. Their physical and photoelectrochemical properties were studied by absorption, emission, electrochemistry and thermog ravimetry. In addition, the gaussian program was used to calculate the geometric configurations of the two derivatives. Since N-HQ has an approximate planar configuration, it is packed in a highly
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Merkulov, V. V., A. I. Almazov, S. K. Kabiyeva, S. N. Mantler, and V. V. Konshin. "A Simple Procedure for Synthesis of Biological Active 4-oxo-4-(quinolin-8-yloxy)but-2-enoic acid." Eurasian Chemico-Technological Journal 24, no. 1 (2022): 51. http://dx.doi.org/10.18321/ectj1148.

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The article is devoted to research on the synthesis of hydroxyquinoline derivative based on 8-oxyquinoline and maleic anhydride. Analysis of available literature was carried out, some drugs were found that are produced based on hydroxyquinoline derivatives and have antiprotozoal, antimicrobial and antiseptic effects, used alone or in combination with other active substances. A technique has been developed for the synthesis of a new derivative in the medium of petroleum distillate using sulfuric acid as a catalyst. A water-soluble ester of 8-oxyquinoline and maleic acid was obtained in good yie
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Cai, Fangjian, Fei Xia, Yingxin Guo, et al. "“Off–on–off” type of selectively pH-sensing 8-hydroxyquinoline-substituted gallium(iii) corrole." New Journal of Chemistry 43, no. 46 (2019): 18012–17. http://dx.doi.org/10.1039/c9nj04544a.

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We herein reported the synthesis and pH sensing property of a novel gallium corrole derivatives based on 8-hydroxyquinoline. Ga-corrole derivative showed good fluorescent response upon changing the pH values in the wide region of pH 1 to 12.
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El Safadi, Mahmoud, Katie A. Wilson, Indigo J. Strudwicke, et al. "Amphetamine-like Deferiprone and Clioquinol Derivatives as Iron Chelating Agents." Molecules 29, no. 17 (2024): 4213. http://dx.doi.org/10.3390/molecules29174213.

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The accumulation of iron in dopaminergic neurons can cause oxidative stress and dopaminergic neuron degeneration. Iron chelation therapy may reduce dopaminergic neurodegeneration, but chelators should be targeted towards dopaminergic cells. In this work, two series of compounds based on 8-hydroxyquinoline and deferiprone, iron chelators that have amphetamine-like structures, have been designed, synthesized and characterized. Each of these compounds chelated iron ions in aqueous solution. The hydroxyquinoline-based compounds exhibited stronger iron-binding constants than those of the deferipron
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Rao, K. T. V., Hima G. Bindu, and Paul S. Douglas. "Facile multi-component one-pot synthesis of 4-amidoaralkyl-3-hydroxyquinolines using ZnO NPs: Evaluation of anti-bacterial and anti-diabetic activity." Research Journal of Chemistry and Environment 26, no. 3 (2022): 85–93. http://dx.doi.org/10.25303/2603rjce8593.

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A three-component one-pot synthesis was performed to obtain 4-amidoaralkyl-3-hydroxyquinolines (4a-j), belonging to heterocyclic class of compounds. These derivatives were obtained by the fusion of 3- hydroxyquinoline (1), aromatic aldehydes (2a-j) and amides (3a-j) in the presence of ZnO nanoparticles under solvent free conditions at 40oC temperature. Using 1HNMR, 13CNMR, FTIR spectral techniques and LC-MS analytical technique, the structural and elemental aspects of the derivatives have been confirmed. Higher yields and less reaction time (1.5 h) were the major outcomes of the protocol and f
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RITA, DIXIT, O. MARATHE D., and S. BHAVE N. "Stability Constants of Neodymium(III) Complexes with 8-Hydroxyquinoline and Its Derivatives." Journal of Indian Chemical Society Vol. 64, Jul 1987 (1987): 435–36. https://doi.org/10.5281/zenodo.6198138.

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University Department of Chemistry, Nagpur University, Nagpur-440 010 <em>Manuscript received 6 August 1980, revised 15 June 1987,&nbsp;</em><em>accepted 6 July 1987</em> Stability Constants of Neodymium(III) Complexes with 8-Hydroxyquinoline and Its Derivatives. &nbsp;
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Dissertations / Theses on the topic "Hydroxyquinoline derivatives"

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Vu, Thi huyen. "Synthesis and Development New 8-Hydroxyquinoline Derivatives for the Treatment of Chlamydia trachomatis Infection." Thesis, Université de Paris (2019-....), 2020. https://wo.app.u-paris.fr/cgi-bin/WebObjects/TheseWeb.woa/wa/show?t=4392&f=28906.

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Chlamydia trachomatis, une bactérie à Gram négatif, est responsable, à la fois, de l'infection bactérienne sexuellement transmissible la plus diagnostiquée dans le monde et du trachome, une cause importante de cécité. Aucun vaccin n'est disponible mais deux antibiotiques (Azithromycine, Doxycycline) sont recommandés par l'Organisation Mondiale de la Santé. Toutefois, un échec du traitement est signalé chez 10 à 20% des patients et résulte probablement d'un manque de sensibilité des formes persistantes de la bactérie et des modestes concentrations intracellulaires des médicaments conventionnell
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Pretorius, Alet. "A preliminary investigation of the potential anticancer properties of 8-hydroxyquinoline derivatives." Diss., University of Pretoria, 2011. http://hdl.handle.net/2263/24884.

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Derivatives of the quinoline moiety have been shown to exert a range of biological activities, including anti-neoplastic activity. The clinical application of quinoline derivatives in the treatment of malignancies has been limited due to non-selectivity. Four novel hydroxyquinoline derivatives were synthesised as potential anticancer agents. Each of these compounds contains the characteristic quinoline nucleus: a heterocyclic moiety containing a nitrogen atom. A hydroxyl group is present on C-8 and an azo bond links the heterocyclic quinoline core to a monocyclic benzene ring with various subs
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Wu, Qingguo. "Luminescent organic and organometallic compounds based on 7-azaindole, 2,2'-dipyridylamine, 8-hydroxyquinoline and derivatives and their electroluminescent applications." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0010/NQ52866.pdf.

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Benaissa, Tahar. "Synthèse de ligands contenant un atome de fluor et pouvant donner des complexes à applications médicales : étude de la complexation de la 5-fluoro-8-hydroxyquinoline avec des cations métalliques, par RMN du fluor." Université Joseph Fourier (Grenoble), 1996. http://www.theses.fr/1996GRE10100.

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Ce travail se place a la convergence de deux grands themes etudies au laboratoire: le marquage de molecules par un atome de fluor et l'etude de la complexation de cations metalliques par des ligands. La premiere partie concerne la preparation de deux series de ligands contenant du fluor: des biphenols et des composes contenant des groupements 2-fluoropyridines. Les biphenols substitues par deux ou quatre atomes de fluor (en position 4,4' ; 5,5' ; 4,4 ;,5,5') ont ete obtenus a partir de bromophenols par une reaction de type ullman. Leurs derives sulfones ont egalement ete prepares pour augmente
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Stewart, Matthew Blair. "Computational and experimental investigations of biologically interesting molecules." Thesis, full-text, 2009. https://vuir.vu.edu.au/1957/.

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The reconciliation of experimental and computational data is an on-going challenge in many fields of scientific enquiry. This is particularly true in chemistry, especially with respect to biologically interesting molecules, given the myriad of problems that now lend themselves to theoretical investigation. This work sampled several areas of this greater landscape using various computational methods, and compared these results to relevant, experimentally derived data.
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Chang, Chun-Yi, and 張峻誼. "Synthesis of 2-Styrylchromone and 8-Hydroxyquinoline Derivatives as Anticancer Agents." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/38371500242574807026.

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碩士<br>淡江大學<br>化學學系碩士班<br>98<br>The first part : A series of 2-styrylchromone analogs were synthesized and examined for their antiproliferative effects on a panel of carcinoma cells. Among the tested agents, only 34 exhibited a moderate activity with an IC50 value of 28.9 μM against PC-3 cells which indicates the selectivity of PC-3 cells in response to 2-styrylchromones. In addition, 38 demonstrated the most antiproliferative effect with an IC50 value of 4.9 μM against HeLa cells. Together, these results suggest a potential structural optimization and pharmacological study of 2-styrylchromones
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Yu-Fang, Jhang, and 張玉芳. "The Photophysical and Photochemical Properties of 2-Styrylquinoline Derivatives：(a) 5-Member Hetero-ring series (b) 8-Hydroxyquinoline series." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/4jws85.

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碩士<br>國立嘉義大學<br>應用化學系研究所<br>96<br>Different 2-styrylquinoline derivatives possessing intramolecular charge transfer characters, including 5-member heterocyclic or 8-hydroxyquinoline, were synthesized to study the influence of substituent on the photophysics and photochemistry. For 5-member heterocyclic derivatives, the basicity of the quinoline ring are enhanced in excited state (pKa ⊿= 8 ~ 10). Comparing with thiophene derivatives, pyrrole ring possesses a stronger electron-donating ability. However, these molecules all practiced an excited state proton transfer (ESPT) reaction in strong hydr
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LIN, KUO-CHEN, and 林國成. "New Hydroxyquinoline-based Derivative Protects Dermal Fibroblasts From Ultraviolet B Irradiation Induced Cytotoxicity." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/65257904670617007060.

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碩士<br>國防醫學院<br>生物化學研究所<br>105<br>This study examined whether a newly synthesized metal chelator hydroxyquinoline based derivative, (HLH2), protects human dermal fibroblasts from ultraviolet B (UVB) irradiation-induced cytotoxicity and skin aging. UVB irradiation increased reactive oxygen species (ROS) levels, subsequently ROS activated the mitochondrial apoptotic pathway. HLH2 inhibited the decrease of UVB-irradiation-induced NQO-1 and HO-1 expression, ROS generation and apoptosis. UVB irradiation activated 12-lipooxygenase and the product of 12-lipooxygenase 12-hydroxyeicosatetraenoic acid (1
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Pellow-Jarman, Martin Vincent. "The liquid-liquid extraction of Germaniun with the 7-alkylated 8- hydroxyquinoline derivative - KELEX 100." Thesis, 1990. http://hdl.handle.net/10413/6133.

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Germanium can be extracted from aqueous solutions by KELEX 100 dissolved in an appropriate diluent. KELEX 100 is a commercially available chelating extractant containing the active constituent 7-(4ethyl-l-methyloctyl)-8-hydroxyquinoline. Previous work in the solvent extraction of germanium with this reagent has shown that germanium is extracted most efficiently at low pH. When the germanium is present in sulphuric acid solutions at pH less than 2, the extracted complex is GeL3+HS04-,however at pH 3 to 8, the metal is extracted as GeL2(OH)2 (where HL = KELEX 100). In this work, the extraction k
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Kuo, CHIA-WEI, and 郭家維. "New Hydroxyquinoline Based Derivative Protects NG108-15 Neuroblastoma x Glioma Hybrid Cells Against Hydrogen Peroxide- or Rotenone-induced Cytotoxicity." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/9k7hk7.

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碩士<br>國防醫學院<br>生物化學研究所<br>107<br>The hybrid cell of neuroblastoma and glioma, NG108-15, would be induced apoptosis by hydrogen peroxide(H2O2) or rotenone. A new hydroxyquinoline-based derivative, DPMQ((E)-2-(4-dimethylamino)phenylimino)methyl)quinolin-8-ol) can take copper into cells, preventing amyloid-β aggregation and ROS level increasing in cell. This study wonders whether DPMQ protect NG108-15 cell from H2O2 or rotenone induced cytotoxicity and the mechanism underlying. Treated NG108-15 with 10μM H2O2 or 1μM rotenone, we found cell viability decreased, ROS level raised, mitochondria membr
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Book chapters on the topic "Hydroxyquinoline derivatives"

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Chung, Kun Hoe, Kwang Yun Cho, Yasuko Asami, Nobutaka Takahashi, and Shigeo Yoshida. "New 4-Hydroxypyridine and 4-Hydroxyquinoline Derivatives as Inhibitors of NADH-Ubiquinone Oxidoreductase in the Respiratory Chain II." In Bioenergetics. Springer US, 1990. http://dx.doi.org/10.1007/978-1-4684-5835-0_8.

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Rbaa, Mohamed, Younes El Kacimi, Brahim Lakhrissi, and Abdelkader Zarrouk. "Advances in the synthesis and use of 8-hydroxyquinoline derivatives as effective corrosion inhibitors for steel in acidic medium." In Environmentally Sustainable Corrosion Inhibitors. Elsevier, 2022. http://dx.doi.org/10.1016/b978-0-323-85405-4.00002-1.

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Rbaa, Mohamed, Mouhsine Galai, Elyor Berdimurodov, et al. "Novel Bio-Based Green and Sustainable Corrosion Inhibitors." In Handbook of Research on Corrosion Sciences and Engineering. IGI Global, 2023. http://dx.doi.org/10.4018/978-1-6684-7689-5.ch012.

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Development of non-toxic and sustainable corrosion inhibitors is greatly needed, in view of these several forms of green corrosion inhibitors natural Chitosan oligosaccharide gained substantial advancement. In this book chapter, the Chitosan oligosaccharide was modified with an 8-hydroxyquinoline derivative to develop a novel bio-based, green, and sustainable mild steel corrosion inhibitor. Fourier transform infrared spectroscopy and nuclear magnetic resonance were used to characterize the modified oligosaccharide. Electrochemical measurements as well as theoretical investigations have been us
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Kumar, N. Sunil, K. N. N. Prasad, S. Chandrasekhar, and J. Thipperudrappa. "Exploring the Solvatochromism in Hydroxyquinoline Derivative: An Experimental and Simulated DFT Study." In Current Perspective to Physical Science Research Vol. 9. B P International, 2024. http://dx.doi.org/10.9734/bpi/cppsr/v9/8417e.

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Conference papers on the topic "Hydroxyquinoline derivatives"

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Kepeňová, Martina, Michaela Benediková, Mária Vilková, Miroslava Litecká, and Ivan Potočňák. "Ionic palladium(II) complexes with nitro and halogen derivatives of 8-hydroxyquinoline." In 2nd International Conference on Chemo and Bioinformatics. Institute for Information Technologies, University of Kragujevac, 2023. http://dx.doi.org/10.46793/iccbi23.443k.

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Four commercially unavailable derivatives of 8-hydroxyquinoline with different functional groups (nitro and halogen) in positions 5 and 7 were prepared: 5-nitro-7-iodo-8-hydroxyquinoline (HNIQ), 5-nitro-7-bromo-8-hydroxyquinoline (HNBrQ), 5-iodo-7-bromo-8-hydroxyquinoline (HIBrQ) and 5-chloro-7-bromo-8-hydroxyquinoline (HClBrQ). Their characterization was performed by IR and NMR spectroscopy, elemental analysis and in the case of HIBrQ and HClBrQ by single crystal X-ray structure analysis. Prepared compounds were used for the synthesis of new palladium(II) complexes NH2(CH3)2[PdCl2(XQ)], where
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Harmošová, Michaela, Martin Kello, Mária Vilková, Erika Samoľová, and Ivan Potočňák. "Synthesis, structure and anticancer activity of Zr(IV) complexes with Schiff bases derived from 8-hydroxyquinoline." In 2nd International Conference on Chemo and Bioinformatics. Institute for Information Technologies, University of Kragujevac, 2023. http://dx.doi.org/10.46793/iccbi23.439h.

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The Schiff base 2-{[(2-hydroxyphenyl)imino]methyl}quinolin-8-ol (HLH) and its 5,7-dibromo- (HBrLH) and 5,7-diiodo-derivatives (HILH), which were prepared by multi-step organic synthesis, were used to synthesize [Zr(L)2]·2DMF (1), [Zr(BrL)2]·DMF (2), and [Zr(IL)2]·2DMF (3) complexes. The prepared products were characterized by elemental analysis, IR and NMR spectroscopy, which also monitored the stability of the prepared substances in DMSO, and in the case of HBrLH, HILH and 3, also by single crystal X-ray structural analysis. In the complex 3, two IL ligands are tetradentately bound to the cen
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Sayfutyarov, R. R., I. V. Taydakov, E. P. Dolotova, et al. "Pt (II)-based complexes with ligands of 8-hydroxyquinoline and its 2-methyl derivative for OLED." In 2018 International Conference Laser Optics (ICLO). IEEE, 2018. http://dx.doi.org/10.1109/lo.2018.8435608.

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Do, Lee Mi, Do Hoon Hwang, Kang Hoon Choi, et al. "Polymer light-emitting diodes of poly(m-phenylene-thiophene) derivative and tris(8-hydroxyquinoline) aluminum heterostructure." In Optical Science, Engineering and Instrumentation '97, edited by Zakya H. Kafafi. SPIE, 1997. http://dx.doi.org/10.1117/12.295543.

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