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Journal articles on the topic 'Hydroxystearic acids'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

Zalambani, Chiara, Lorenzo Anconelli, Natalia Calonghi, et al. "New Compounds with Enhanced Biological Activity Through the Strategic Introduction of Silylated Groups into Hydroxystearic Acids." Molecules 30, no. 3 (2025): 440. https://doi.org/10.3390/molecules30030440.

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In the field of medicinal chemistry, the introduction of silylated groups is an important strategy to alter the activity, selectivity, and pharmacokinetics of compounds based on the diverse traits of silicon, including atomic size, electronegativity, and hydrophobicity. The hydroxy group on C-9 or C-9 and C-10 of hydroxystearic acids have been functionalized as t-butyl dimethyl silyl ether. The target compounds have been fully characterized and tested for in vitro cytotoxicity in tumor cells HT29, HCT116, CaCo2, HeLa, MCF7, U2OS, and Jurkat J6 and normal I407 cells. In particular, the silyl de

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2

C., V. CHANDRASEKHARAN, and K. BASU A. "Synthesis, Characterisation and Surfactant Behaviours of Acylaminoethyl Esters of Fatty Acids." Journal of Indian Chemical Society Vol. 73, Feb- Mar 1996 (1996): 123–28. https://doi.org/10.5281/zenodo.5892307.

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Balmer Lawrie & Co. Ltd., 21 N. S. Road, Calcutta-700 001 Department of Chemical Technology, University of Calcutta, 92 A. P. C. Road, Calcutta-700 009 <em>Manuscript received 26 April 1994, accepted 22 July 1994</em> Acylaminoethyl esters of myristic, stearic, 12-hydroxystearic, oleic, ricinoleic and erucic acids have been synthesised at 60° using immobilised lipase as catalyst through the esterification of monoethanolamine with the respective fatty acid. Various surfactant properties of the synthesised esters have been evaluated and compared.

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Stan, Raluca, Nicoleta Chira, Cristina Ott, Cristina Todasca, and Emile Perez. "Catanionic Organogelators Derived from D-Sorbitol and Natural Fatty Acids." Revista de Chimie 59, no. 3 (2008): 273–76. http://dx.doi.org/10.37358/rc.08.3.1747.

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Several catanionic organogelators derived from 1,3 :2,4-bis-O-(p-aminobenzylidene)-D-sorbitol (p-NH2-DBS) and hydroxy derivatives of natural fatty acids were synthesized, characterized and their gelation ability was evaluated. SEM observations of the xerogels formed by association of 1,3 :2,4-bis-O-(p-aminobenzylidene)-D-sorbitol and 12-hydroxystearic acid showed important modifications in the morphology and depend upon the nature of solvent as compared with the xerogels formed by each individual organogelator.

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4

Kokotou, Maroula G., Christiana Mantzourani, Asimina Bourboula, Olga G. Mountanea, and George Kokotos. "A Liquid Chromatography-High Resolution Mass Spectrometry (LC-HRMS) Method for the Determination of Free Hydroxy Fatty Acids in Cow and Goat Milk." Molecules 25, no. 17 (2020): 3947. http://dx.doi.org/10.3390/molecules25173947.

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A liquid chromatography–high resolution mass spectrometry (LC-HRMS) method for the direct determination of various saturated hydroxy fatty acids (HFAs) in milk was developed for the first time. The method involves mild sample preparation conditions, avoids time-consuming derivatization procedures, and permits the simultaneous determination of 19 free HFAs in a single 10-min run. This method was validated and applied in 17 cow milk and 12 goat milk samples. This work revealed the existence of various previously unrecognized hydroxylated positional isomers of palmitic acid and stearic acid in bo

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Dongoran, Rachmad Anres, Tsung-Jen Lin, Akhsholphan Byekyet, Sheau-Chung Tang, Jen-Hung Yang, and Chin-Hung Liu. "Determination of Major Endogenous FAHFAs in Healthy Human Circulation: The Correlations with Several Circulating Cardiovascular-Related Biomarkers and Anti-Inflammatory Effects on RAW 264.7 Cells." Biomolecules 10, no. 12 (2020): 1689. http://dx.doi.org/10.3390/biom10121689.

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Fatty acid esters of hydroxy fatty acids (FAHFAs) are newly discovered long-chain fatty acids. However, the major endogenous FAHFAs in healthy human circulation, their correlation with cardiovascular (CV) biomarkers, and their anti-inflammatory effects have not been investigated and remain unclear. In the present study, a total of 57 healthy subjects were recruited. Liquid chromatography–mass spectrometry (LC-MS) was developed for the simultaneous determination of seven FAHFAs, four long-chain fatty acids, and four non-traditional circulating CV-related biomarkers. We found two major types of

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6

Dari, Carolina, Fabrice Cousin, Clemence Le Coeur, et al. "Ultrastable and Responsive Foams Based on 10-Hydroxystearic Acid Soap for Spore Decontamination." Molecules 28, no. 11 (2023): 4295. http://dx.doi.org/10.3390/molecules28114295.

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Currently, there is renewed interest in using fatty acid soaps as surfactants. Hydroxylated fatty acids are specific fatty acids with a hydroxyl group in the alkyl chain, giving rise to chirality and specific surfactant properties. The most famous hydroxylated fatty acid is 12-hydroxystearic acid (12-HSA), which is widely used in industry and comes from castor oil. A very similar and new hydroxylated fatty acid, 10-hydroxystearic acid (10-HSA), can be easily obtained from oleic acid by using microorganisms. Here, we studied for the first time the self-assembly and foaming properties of R-10-HS

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7

Medina, S., J. J. Benítez, M. A. Castro, C. Cerrillos, C. Millán, and M. D. Alba. "Monolayer arrangement of fatty hydroxystearic acids on graphite: Influence of hydroxyl groups." Thin Solid Films 539 (July 2013): 194–200. http://dx.doi.org/10.1016/j.tsf.2013.05.053.

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8

Hagedoorn, Peter Leon, Frank Hollmann, and Ulf Hanefeld. "Novel oleate hydratases and potential biotechnological applications." Applied Microbiology and Biotechnology 105, no. 16-17 (2021): 6159–72. http://dx.doi.org/10.1007/s00253-021-11465-x.

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Abstract Oleate hydratase catalyses the addition of water to the CC double bond of oleic acid to produce (R)-10-hydroxystearic acid. The enzyme requires an FAD cofactor that functions to optimise the active site structure. A wide range of unsaturated fatty acids can be hydrated at the C10 and in some cases the C13 position. The substrate scope can be expanded using ‘decoy’ small carboxylic acids to convert small chain alkenes to secondary alcohols, albeit at low conversion rates. Systematic protein engineering and directed evolution to widen the substrate scope and increase the conversion rate

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9

Ebert, Cynthia, Fulvia Felluga, Cristina Forzato, et al. "Enzymatic kinetic resolution of hydroxystearic acids: A combined experimental and molecular modelling investigation." Journal of Molecular Catalysis B: Enzymatic 83 (November 2012): 38–45. http://dx.doi.org/10.1016/j.molcatb.2012.06.017.

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10

Kartun, I. M., and B. F. Kochirko. "Active substances of a solid corrosion inhibitor for the oil and gas industry." Voprosy Khimii i Khimicheskoi Tekhnologii, no. 1 (February 2024): 21–28. http://dx.doi.org/10.32434/0321-4095-2024-152-1-21-28.

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This paper reports the method of synthesis and the results of the investigation of the components of a solid corrosion inhibitor intended for the protection of equipment of gas-condensate and oil wells. 1-Amidohydroxystearate-diethyldiamine-2-hydroxystearylimidazoline was synthesized by the interaction of hydroxystearic acid with triethyltetramine. By chemical transformation of pork fat with triethyltetramine, amidoamines of fatty acids were synthesized. The passage of the relevant chemical reactions was confirmed by the methods of infrared spectroscopy and gas chromatographic analysis. The gr

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11

Espinosa-Dzib, Alejandra, and Sergey Vyazovkin. "Nanoconfined gelation in systems based on stearic and 12-hydroxystearic acids: A calorimetric study." Journal of Molecular Liquids 335 (August 2021): 116191. http://dx.doi.org/10.1016/j.molliq.2021.116191.

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12

Yarova, Galina, William Lathrop, John Nip, et al. "33261 Topically applied skin natural fatty acids and 12-hydroxystearic acid boosts barrier lipids." Journal of the American Academy of Dermatology 87, no. 3 (2022): AB214. http://dx.doi.org/10.1016/j.jaad.2022.06.888.

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13

Serra, Stefano, Davide De Simeis, Antonio Castagna, and Mattia Valentino. "The Fatty-Acid Hydratase Activity of the Most Common Probiotic Microorganisms." Catalysts 10, no. 2 (2020): 154. http://dx.doi.org/10.3390/catal10020154.

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In this work, we studied the biotechnological potential of thirteen probiotic microorganisms currently used to improve human health. We discovered that the majority of the investigated bacteria are able to catalyze the hydration reaction of the unsaturated fatty acids (UFAs). We evaluated their biocatalytic activity toward the three most common vegetable UFAs, namely oleic, linoleic, and linolenic acids. The whole-cell biotransformation experiments were performed using a fatty acid concentration of 3 g/L in anaerobic conditions. Through these means, we assessed that the main part of the invest

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14

Calonghi, Natalia, Carla Boga, Patrizia Nitti, et al. "Effects of Regioisomerism on the Antiproliferative Activity of Hydroxystearic Acids on Human Cancer Cell Lines." Molecules 27, no. 8 (2022): 2396. http://dx.doi.org/10.3390/molecules27082396.

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A series of regioisomers of the hydroxystearic acid (HSA) was prepared, and the effect of the position of the hydroxyl group along the chain on a panel of human cancer cell lines was investigated. Among the various regioisomers, those carrying the hydroxyl at positions 5, 7, and 9 had growth inhibitor activity against various human tumor cell lines, including CaCo-2, HT29, HeLa, MCF7, PC3, and NLF cells. 10-HSA and 11-HSA showed a very weak effect. 8-HSA did not show inhibitory activity in all cell lines. The biological role of 7-HSA and 9-HSA is widely recognized, while little is known about

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15

Kokotou, Maroula G. "Determination of Free Fatty Acids in Breast Milk Reveals the Presence of Hydroxypalmitic and Stearic Acids." Biomolecules 14, no. 12 (2024): 1602. https://doi.org/10.3390/biom14121602.

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Breast milk is a rich source of fatty acids (FAs) while being irreplaceable for the health and development of an infant. Herein, we present a fast and simple method for the direct detection and quantification of 37 free FAs (FFAs) in breast milk samples, avoiding any derivatization step, and a study on the % variation of FA contents in samples collected from the same mother within five consecutive days. The average breakdown of FAs was 60.5% saturated and 39.5% unsaturated, in which polyunsaturated FAs were 13.3% and monounsaturated FAs 26.2%. The most abundant FFA in the breast milk samples w

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16

Mountanea, Olga G., Christiana Mantzourani, Dimitrios Gkikas, Panagiotis K. Politis, and George Kokotos. "Asymmetric Synthesis of Saturated and Unsaturated Hydroxy Fatty Acids (HFAs) and Study of Their Antiproliferative Activity." Biomolecules 14, no. 1 (2024): 110. http://dx.doi.org/10.3390/biom14010110.

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Hydroxy fatty acids (HFAs) constitute a class of lipids, distinguished by the presence of a hydroxyl on a long aliphatic chain. This study aims to expand our insights into HFA bioactivities, while also introducing new methods for asymmetrically synthesizing unsaturated and saturated HFAs. Simultaneously, a procedure previously established by us was adapted to generate new HFA regioisomers. An organocatalytic step was employed for the synthesis of chiral terminal epoxides, which either by alkynylation or by Grignard reagents resulted in unsaturated or saturated chiral secondary alcohols and, ul

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17

Almeida, Maëva, Daniel Dudzinski, Catherine Amiel, et al. "Aqueous Binary Mixtures of Stearic Acid and Its Hydroxylated Counterpart 12-Hydroxystearic Acid: Cascade of Morphological Transitions at Room Temperature." Molecules 28, no. 11 (2023): 4336. http://dx.doi.org/10.3390/molecules28114336.

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Here, we describe the behavior of mixtures of stearic acid (SA) and its hydroxylated counterpart 12-hydroxystearic acid (12-HSA) in aqueous mixtures at room temperature as a function of the 12-HSA/SA mole ratio R. The morphologies of the self-assembled aggregates are obtained through a multi-structural approach that combines confocal and cryo-TEM microscopies with small-angle neutron scattering (SANS) and wide-angle X-ray scattering (WAXS) measurements, coupled with rheology measurements. Fatty acids are solubilized by an excess of ethanolamine counterions, so that their heads are negatively c

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18

Syed, Ismail, Jennifer Lee, Pedro M. Moraes-Vieira, et al. "Palmitic Acid Hydroxystearic Acids Activate GPR40, Which Is Involved in Their Beneficial Effects on Glucose Homeostasis." Cell Metabolism 27, no. 2 (2018): 419–27. http://dx.doi.org/10.1016/j.cmet.2018.01.001.

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19

Boga, Carla, Silvia Puggioli, Marica Gherpelli, et al. "Fluorescein conjugates of 9- and 10-hydroxystearic acids: synthetic strategies, photophysical characterization, and confocal microscopy applications." Analytical Biochemistry 335, no. 2 (2004): 196–209. http://dx.doi.org/10.1016/j.ab.2004.09.014.

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20

Mantzourani, Christiana, and Maroula G. Kokotou. "Targeted and Suspect Fatty Acid Profiling of Royal Jelly by Liquid Chromatography—High Resolution Mass Spectrometry." Biomolecules 13, no. 3 (2023): 424. http://dx.doi.org/10.3390/biom13030424.

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Royal jelly (RJ) is a bee product produced by the mandibular and hypopharyngeal glands of worker honeybees which has attracted special attention because of its numerous pharmacological activities and its applications to dermatology and cosmetics. In 2020, we demonstrated a liquid chromatography–high resolution mass spectrometry (LC–HRMS) method for the determination of seven medium-chain FFAs in RJ samples. The aim of the present work was to extend our studies on FA profiling of RJ, exploring the presence of common long-chain saturated, mono-unsaturated and poly-unsaturated free FAs in RJ samp

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di Bitonto, Luigi, Antonella Angelini, and Carlo Pastore. "Energy Recovery from Municipal Sewage Sludge: An Environmentally Friendly Source for the Production of Biochemicals." Applied Sciences 14, no. 12 (2024): 4974. http://dx.doi.org/10.3390/app14124974.

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In this work, a detailed analysis of the lipid component in primary sludge and sewage scum up-taken from several wastewater treatment plants located in southern Italy was carried out. Lipids in the primary sludge accounted for 200–250 mg/g of the total solids (TS), with calcium soaps as a main component (70–82%), while total lipids made up about 350–500 mg/gTS in the sewage scum and consisted mainly of FFAs (45–60%) and calcium soaps (27–35%). In addition, estolides and 10-hydroxystearic acid were also quantified. A specific valorization process was then developed and tested for either primary

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22

Rodríguez, Juan P., Carlos Guijas, Alma M. Astudillo, Julio M. Rubio, María A. Balboa, and Jesús Balsinde. "Sequestration of 9-Hydroxystearic Acid in FAHFA (Fatty Acid Esters of Hydroxy Fatty Acids) as a Protective Mechanism for Colon Carcinoma Cells to Avoid Apoptotic Cell Death." Cancers 11, no. 4 (2019): 524. http://dx.doi.org/10.3390/cancers11040524.

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Hydroxy fatty acids are known to cause cell cycle arrest and apoptosis. The best studied of them, 9-hydroxystearic acid (9-HSA), induces apoptosis in cell lines by acting through mechanisms involving different targets. Using mass spectrometry-based lipidomic approaches, we show in this study that 9-HSA levels in human colorectal tumors are diminished when compared with normal adjacent tissue. Since this decrease could be compatible with an escape mechanism of tumors from 9-HSA-induced apoptosis, we investigated different features of the utilization of this hydroxyfatty acid in colon. We show t

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Qin, Linlin, Na An, Bifeng Yuan, Quanfei Zhu, and Yuqi Feng. "The Metabolomic Characteristics and Dysregulation of Fatty Acid Esters of Hydroxy Fatty Acids in Breast Cancer." Metabolites 13, no. 11 (2023): 1108. http://dx.doi.org/10.3390/metabo13111108.

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Lipid reprogramming metabolism is crucial for supporting tumor growth in breast cancer and investigating potential tumor biomarkers. Fatty acid esters of hydroxy fatty acids (FAHFAs) are a class of endogenous lipid metabolites with anti-diabetic and anti-inflammatory properties that have been discovered in recent years. Our previous targeted analysis of sera from breast cancer patients revealed a significant down-regulation of several FAHFAs. In this study, we aimed to further explore the relationship between FAHFAs and breast cancer by employing chemical isotope labeling combined with liquid

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Bertucci, C., M. Hudaib, C. Boga, N. Calonghi, C. Cappadone, and L. Masotti. "Gas chromatography/mass spectrometric assay of endogenous cellular lipid peroxidation products: quantitative analysis of 9- and 10-hydroxystearic acids." Rapid Communications in Mass Spectrometry 16, no. 9 (2002): 859–64. http://dx.doi.org/10.1002/rcm.656.

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Cristofolini, Luigi, Marco P. Fontana, Carla Boga, and Oleg Konovalov. "Microscopic Structure of Crystalline Langmuir Monolayers of Hydroxystearic Acids by X-ray Reflectivity and GID: OH Group Position and Dimensionality Effect." Langmuir 21, no. 24 (2005): 11213–19. http://dx.doi.org/10.1021/la0514213.

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Spitzer, V., S. A. de L. Bordignon, E. P. Schenkel, and F. Marx. "Identification of nine acetylenic fatty acids, 9-hydroxystearic acid and 9,10-epoxystearic acid in the seed oil ofJodina rhombifoliahook et arn. (Santalaceae)." Journal of the American Oil Chemists' Society 71, no. 12 (1994): 1343–48. http://dx.doi.org/10.1007/bf02541352.

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27

Boratyński, Filip, Ewa Szczepańska, Davide De Simeis, Stefano Serra та Elisabetta Brenna. "Bacterial Biotransformation of Oleic Acid: New Findings on the Formation of γ-Dodecalactone and 10-Ketostearic Acid in the Culture of Micrococcus luteus". Molecules 25, № 13 (2020): 3024. http://dx.doi.org/10.3390/molecules25133024.

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Microbial conversion of oleic acid (1) to form value-added industrial products has gained increasing scientific and economic interest. So far, the production of natural lactones with flavor and fragrance properties from fatty acids by non-genetically modified organisms (non-GMO) involves whole cells of bacteria catalyzing the hydration of unsaturated fatty acids as well as yeast strains responsible for further β-oxidation processes. Development of a non-GMO process, involving a sole strain possessing both enzymatic activities, significantly lowers the costs of the process and constitutes a bet

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28

Jenkins, Thomas C., Amer A. AbuGhazaleh, Sharon Freeman, and Evanne J. Thies. "The Production of 10-Hydroxystearic and 10-Ketostearic Acids Is an Alternative Route of Oleic Acid Transformation by the Ruminal Microbiota in Cattle." Journal of Nutrition 136, no. 4 (2006): 926–31. http://dx.doi.org/10.1093/jn/136.4.926.

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29

Márquez-Ruiz, G., V. Rodríguez-Pino, and M. A. de la Fuente. "Determination of 10-hydroxystearic, 10-ketostearic, 8-hydroxypalmitic, and 8-ketopalmitic acids in milk fat by solid-phase extraction plus gas chromatography-mass spectrometry." Journal of Dairy Science 94, no. 10 (2011): 4810–19. http://dx.doi.org/10.3168/jds.2011-4424.

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30

Liu, Sihan, Shaohua Wu, Hao Zhang, and Xingchu Gong. "Developing a Quantitative Profiling Method for Detecting Free Fatty Acids in Crude Lanolin Based on Analytical Quality by Design." Chemosensors 13, no. 4 (2025): 126. https://doi.org/10.3390/chemosensors13040126.

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In this study, a quantitative profiling method for detecting free fatty acids in crude lanolin based on the Quality by Design (QbD) concept was developed. High-performance liquid chromatography (HPLC) equipped with a charged aerosol detector (CAD) and a Proshell 120 EC C18 column was employed for the separation of crude lanolin components. Initially, the analytical target profile and critical method attributes were defined. Potential critical method parameters, including column temperature, flow rate, isocratic run time, gradient end organic phase ratio, and gradient time, were identified usin

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Soto-Avellaneda, Alejandro, Alexandra E. Oxford, Fabio Halla, et al. "FABP5-binding lipids regulate autophagy in differentiated SH-SY5Y cells." PLOS ONE 19, no. 6 (2024): e0300168. http://dx.doi.org/10.1371/journal.pone.0300168.

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The motor features of Parkinson’s disease result from loss of dopaminergic neurons in the substantia nigra with autophagy dysfunction being closely linked to this disease. While a large body of work focusing on protein effectors of autophagy has been reported, regulation of autophagy by lipids has garnered far less attention. Therefore, we sought to identify endogenous lipid molecules that act as signaling mediators of autophagy in differentiated SH-SY5Y cells, a commonly used dopaminergic neuron-like cell model. In order to accomplish this goal, we assessed the role of a fatty acid-binding pr

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Luo, Qiuhua, Wen Shi, Puxiu Wang, Yu Zhang, Jia Meng, and Ling Zhang. "Tumor Microenvironment-Responsive Shell/Core Composite Nanoparticles for Enhanced Stability and Antitumor Efficiency Based on a pH-Triggered Charge-Reversal Mechanism." Pharmaceutics 13, no. 6 (2021): 895. http://dx.doi.org/10.3390/pharmaceutics13060895.

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High systemic stability and effective tumor accumulation of chemotherapeutic agents are indispensable elements that determine their antitumor efficacy. PEGylation of nanoparticles (NPs) could prolong the retention time in vivo by improving their stability in circulation, but treatment suffers reduced tumor penetration and cellular uptake of nanomedicines. The tumor microenvironment (TME)-responsive NPs maintain their stealth features during circulation and undergo a stimuli-responsive dePEGylation once exposed to the site of action, thereby achieving enhanced internalization in tumor cells. He

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Ahn, WonSool, and Joon-Man Lee. "Open-Cell Rigid Polyurethane Foam Using Lithium Salt of 12-Hydroxystearic acid as a Cell Opening Agent." Polymer Korea 42, no. 6 (2018): 919–24. http://dx.doi.org/10.7317/pk.2018.42.6.919.

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Kuhn, Jasmin, Yi Lin, Ana Krhac Levacic, et al. "Delivery of Cas9/sgRNA Ribonucleoprotein Complexes via Hydroxystearyl Oligoamino Amides." Bioconjugate Chemistry 31, no. 3 (2020): 729–42. https://doi.org/10.1021/acs.bioconjchem.9b00853.

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<strong>Abstract</strong> The programmable endonuclease activity and simple usage of CRISPR/Cas9 have revolutionized the field of genome editing. The binding of single guide RNA (sgRNA) by the Cas9 protein results in the formation of negatively charged ribonucleoprotein (RNP) complexes. The presence of this functional complex inside cells is imperative for the intended specific genome modifications. The direct intracellular delivery of Cas9/sgRNA RNP complexes is of great advantage. In this work, a compound library of sequence-defined oligo(ethylenamino) amides containing structural motifs for

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"Amended Final Report on the Safety Assessment of Hydroxystearic Acid1." International Journal of Toxicology 18, no. 1_suppl (1999): 1–10. http://dx.doi.org/10.1177/109158189901801s02.

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Hydroxystearic Acid is a fatty acid used as a surfactant–cleansing agent in cosmetic products. Initial review of available safety test data resulted in a finding that there were insufficient data to support the safety of Hydroxystearic Acid for use in cosmetic products. Data needed included concentration of use, chemical characterization, dermal reproductive and developmental toxicity, genotoxicity (and carcinogenicity data if the genotoxicity data were positive), and shin irritation data. Subsequent to that conclusion, new data were received. Use concentrations were reported as high as 10%. S

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Oike, Keiko, Rob Schoevaart, Frank Hollmann, Ulf Hanefeld, and Peter-Leon Hagedoorn. "Immobilization of Oleate Hydratase on Solid Supports." ChemCatChem, May 14, 2024. http://dx.doi.org/10.1002/cctc.202301708.

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Oleate hydratases open a biocatalytic access to hydroxy fatty acids by hydration of unsaturated fatty acids. Their practical applicability, however, is hampered by their low stability. In this study we report the immobilization of the oleate hydratase from Rhodococcus erythropolis PR4 on functionalized porous, spherical polymer beads. Different carrier materials promoting covalent, hydrophobic, ionic and his‐tag affinity were screened and immobilization yields typically >95% were observed. The highest activity recovery of 32% was achieved by immobilization via ionic interaction with quatern

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Biundo, Antonino, Arne Stamm, Ruggiero Gorgoglione, et al. "Regio- and stereoselective biocatalytic hydration of fatty acids from waste cooking oils en route to hydroxy fatty acids and bio-based polyesters." Enzyme and Microbial Technology 163 (November 19, 2022). https://doi.org/10.1016/j.enzmictec.2022.110164.

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The development of biorefinery approaches is of great relevance for the sustainable production of valuable compounds. In accordance with circular economy principles, waste cooking oils (WCOs) are renewable resources and biorefinery feedstocks, which contribute to a reduced impact on the environment. Frequently, this waste is wrongly disposed of into municipal sewage systems, thereby creating problems for the environment and increasing treatment costs in wastewater treatment plants. In this study, regenerated WCOs, which were intended for the production of biofuels, were transformed through a c

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"Use of Lactobacillus rhamnosus (ATCC 53103) as Whole-Cell Biocatalyst for the Regio- and Stereoselective Hydration of Oleic, Linoleic, and Linolenic Acid." Catalysts 8, no. 3 (2018): 109. http://dx.doi.org/10.3390/catal8030109.

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Natural hydroxy fatty acids are relevant starting materials for the production of a number of industrial fine chemicals, such as different high-value flavour ingredients. Only a few of the latter hydroxy acid derivatives are available on a large scale. Therefore, their preparation by microbial hydration of unsaturated fatty acids, affordable from vegetable oils, is a new biotechnological challenge. In this study, we describe the use of the probiotic bacterium Lactobacillus rhamnosus (ATCC 53103) as whole-cell biocatalyst for the hydration of the most common unsaturated octadecanoic acids, name

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Serra, Stefano, Simeis Davide De, Antonio Castagna, and Mattia Valentino. "The Fatty-Acid Hydratase Activity of the Most Common Probiotic Microorganisms." January 28, 2020. https://doi.org/10.3390/catal10020154.

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In this work, we studied the biotechnological potential of thirteen probiotic microorganisms currently used to improve human health. We discovered that the majority of the investigated bacteria are able to catalyze the hydration reaction of the unsaturated fatty acids (UFAs). We evaluated their biocatalytic activity toward the three most common vegetable UFAs, namely oleic, linoleic, and linolenic acids. The whole-cell biotransformation experiments were performed using a fatty acid concentration of 3 g/L in anaerobic conditions. Through these means, we assessed that the main part of the invest

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Hammarstedt, Ann, Ismail Syed, Archana Vijayakumar, et al. "Adipose tissue dysfunction is associated with low levels of the novel Palmitic Acid Hydroxystearic Acids." Scientific Reports 8, no. 1 (2018). http://dx.doi.org/10.1038/s41598-018-34113-3.

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Zhao, Yi-Fan, Wen-Liang Xie, Kai He, Hai-Peng Li, Jiang Pan, and Jian-He Xu. "Continuous Flow Microreactors for the High‐efficiency Enzymatic Synthesis of 10‐Hydroxystearic Acid from Oleic Acid." ChemBioChem, August 2024. http://dx.doi.org/10.1002/cbic.202400345.

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Converting fatty acids into specialty chemicals is sustainable but hindered by the low efficiency and thermal instability of current oleic acid hydratases, along with mass transfer limitations in emulsion reactions. This study introduces an optimized continuous flow micro‐reactor (CFMR) that efficiently transforms oleic acid at low (15 g·L‐1) and high (50 g·L‐1) concentrations, improving reaction efficiency and overcoming key conversion barriers. The first CFMR model showed reaction speeds surpassing traditional batch stirred tank reactors (BSTR). Optimizations were performed on three key comp

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Rawlings, Anthony V., Eliane Wandeler, Igor Bendik, et al. "Effect of regioisomers of hydroxystearic acids as peroxisomal proliferator‐activated receptor agonists to boost the anti‐ageing potential of retinoids." International Journal of Cosmetic Science, September 5, 2021. http://dx.doi.org/10.1111/ics.12730.

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Iizuka, Katsumi, Ken Takao, and Daisuke Yabe. "ChREBP-Mediated Regulation of Lipid Metabolism: Involvement of the Gut Microbiota, Liver, and Adipose Tissue." Frontiers in Endocrinology 11 (December 3, 2020). http://dx.doi.org/10.3389/fendo.2020.587189.

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Carbohydrate response element-binding protein (ChREBP) plays an important role in the development of type 2 diabetes, dyslipidemia, and non-alcoholic fatty liver disease, as well as tumorigenesis. ChREBP is highly expressed in lipogenic organs, such as liver, intestine, and adipose tissue, in which it regulates the production of acetyl CoA from glucose by inducing Pklr and Acyl expression. It has recently been demonstrated that ChREBP plays a role in the conversion of gut microbiota-derived acetate to acetyl CoA by activating its target gene, Acss2, in the liver. ChREBP regulates fatty acid sy

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Lu, Chenyu, Jiaoqi Ren, Shanshan Huang, Meng Wang, Houguang Zhou та Jingchun Guo. "S‐9‐PAHSA Attenuates Aβ Accumulation and Improves Cognitive Deficits by Promoting Mitochondrial Autophagy in 5xFAD Mice". European Journal of Neuroscience 61, № 8 (2025). https://doi.org/10.1111/ejn.70118.

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ABSTRACTAlzheimer's disease (AD) is a prevalent neurodegenerative disorder characterized by significant cognitive impairment and predominantly affects the elderly. With no effective cure available, research continues to explore novel therapeutic and preventive strategies. Recently, palmitic acid‐hydroxystearic acids (PAHSAs), especially their stereochemistry S‐configuration, have shown potential as a dietary supplement with anti‐inflammatory and anti‐diabetic properties. We previously found that one of the PAHSAs, 9‐PAHSA, could improve cognitive impairment in the high‐fat‐diet mice, however,

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Vanderway, David R., Hekmat B. Alhmadi, Joshua D. Diaz, Lisa Wen, and Jenq‐Kuen Huang. "Molecular Cloning and Expression of an Oleate Hydratase From Nocardia Cholesterolicum NRRL 5767." FASEB Journal 30, S1 (2016). http://dx.doi.org/10.1096/fasebj.30.1_supplement.838.2.

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The production of household cooking oils in an industrial setting yields soapstock as a byproduct during the refining process. Soapstock contains a significant amount of oleic acid and due to soapstocks very low price, it serves as a cheap source of oleic acid. Oleate hydratase (Ohase) converts oleic acid to the industrially useful product 10(R)‐hydroxystearic acid (10‐HSA), in a regioselective manner. Classically, 10‐HSA is utilized to thicken grease, but it has potential to be used in the production of plastics, lubricants and other various industrially relevant materials. Barring the use of

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LEE, JENNIFER, KERRY WELLENSTEIN, and BARBARA B. KAHN. "1405-P: Bacteroides thetaiotaomicron Fortifies the Gut Mucosa and Improves Host Metabolism in Dietary Obese Mice." Diabetes 71, Supplement_1 (2022). http://dx.doi.org/10.2337/db22-1405-p.

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Disruption of the intestinal mucosa contributes to insulin resistance in obesity and Type 2 diabetes. Probiotic supplementation, which restores gut microbiota composition and fortifies intestinal barrier function, has therapeutic potential to treat obesity and metabolic disease. Treatment of mice on a chow diet or high fat diet (HFD) with Palmitic Acid Hydroxystearic Acids (PAHSAs) improves insulin sensitivity. These effects are mediated, at least in part, by changes in the gut microbiome. We used this paradigm to identify new microbes that may have beneficial metabolic effects. Metagenome seq

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