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Journal articles on the topic 'Hygienic Laboratory (U.S.)'
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Sienes Bailo, Paula, María Santamaría González, Silvia Izquierdo Álvarez, Raquel Lahoz Alonso, Patricia Serrano Frago, and José Luis Bancalero Flores. "A study of crystalluria: effectiveness of including hygienic-dietary recommendations in laboratory reports." Advances in Laboratory Medicine / Avances en Medicina de Laboratorio 2, no. 1 (February 10, 2021): 109–14. http://dx.doi.org/10.1515/almed-2020-0124.
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Abstract Objectives To assess the effectiveness of incorporating hygienic-dietary recommendations in laboratory reports in reducing the incidence of renal colic (RC). A study was performed to compare the incidence of RC in two groups of patients who had suffered at least a crystalluria event associated with the risk of urolithiasis. Recommendations were only incorporated in the laboratory reports of one group. Methods A retrospective observational study. The study sample was composed of patients who had at least an episode of crystalluria associated with a higher risk of urolithiasis. The laboratory reports of patients in Group A (n=1,115), treated in 2017, did not include any hygienic-dietary recommendations, whereas patients in Group B (n=1,692), treated in 2018, received hygienic-dietary recommendations through their laboratory reports. χ2 and Mann-Whitney U test were used to assess differences based on sex, age, and type of urinary crystals. Results The incidence of RC was 2.02 times higher in group A (2.24%) than in group B (1.12%). No significant differences were observed in the incidence of RC based on the type of urinary crystal. The incidence of RC was substantially higher in patients who suffered at least an event of crystalluria associated with a higher risk for urolithiasis as compared to the general population during the same period (0.46%, consistently with the incidence rates reported in the literature). Conclusions The incorporation of messages alerting on the risk of urolithiasis and the inclusion of hygienic-dietary recommendations in laboratory reports may be useful for reducing the incidence of RC.
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Adamović, Dragan. "Occupational safety in the medical laboratory and formaldehyde exposture." Sigurnost 62, no. 2 (July 8, 2020): 105–14. http://dx.doi.org/10.31306/s.62.2.7.
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SAŽETAK: Opasne kemijske tvari u raznim oblicima narušavaju kakvoću zraka u radnoj okolini. Način unošenja otrovnih tvari u ljudsko tijelo i transformacijski putovi glavni su čimbenici štetnih učinaka. Zbog velike raširenosti formaldehida u mnogim industrijama već nekoliko desetljeća pozornost stručnjaka zaštite na radu usmjerena je na taj fenomen. Studija prikazuje temeljne karakteristike formaldehida i učinke na zdravlje prouzročene izlaganjem različitim koncentracijama te opasne tvari. Težište je na zaposlenima u medicinskim laboratorijima gdje se formaldehid koristi kao sredstvo za dezinfekciju i agens za čuvanje uzoraka tkiva u anatomskim laboratorijima. Eksperimentalni dio studije odrađen je u laboratorijima Odjela za anatomiju, a razine koncentracije formaldehida praćene su u različitim prostorijama kako bi se utvrdila izloženost zaposlenika.
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Cleary, F. J. "THE MATERIAL LABORATORY, U. S. NAVY YARD, NEW YORK." Journal of the American Society for Naval Engineers 43, no. 1 (March 18, 2009): 54–104. http://dx.doi.org/10.1111/j.1559-3584.1931.tb03736.x.
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Purves, Byron. "QUALIFICATION STRATEGIES FOR THE INTERNATIONAL SPACE STATION U. S. LABORATORY." INCOSE International Symposium 6, no. 1 (July 1996): 1124–28. http://dx.doi.org/10.1002/j.2334-5837.1996.tb02131.x.
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Bukuya, Melinda, Teresa Martinelli, Joanne Tzouroutis, Elizabeth Duncan, Katie Welldon, Margaret Collecutt, Heather Aumann, Jim Thom, Grace Gilmore, and Emmanuel Favaloro. "A Comparative Multi-laboratory Assessment of Three Factor VIII/von Willebrand Factor Concentrates." Thrombosis and Haemostasis 87, no. 03 (2002): 466–76. http://dx.doi.org/10.1055/s-0037-1613027.
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SummaryFive expert laboratories have participated in a cross-laboratory study to co-evaluate and compare three commercial Factor VIII/von Willebrand factor (VWF) concentrates. A total of nine factor concentrate lots were evaluated, comprising AHF (High Purity) (AHF HP; X3), Biostate® (X3) and Humate/Haemate (X3). All laboratories blind tested for FVIII:C, VWF:Ag and VWF:CB, four tested for VWF:RCo, and one performed VWF:Multimers. The study yielded inter-laboratory CVs for VWF:Ag and FVIII:C around 10–15%, and for VWF:CB and VWF:RCo around 20%, significantly lower than those of previous multi-laboratory surveys. All three lots of AHF HP contained in the vicinity of 25 U/ml FVIII:C, around 60–75 U/ml of VWF:Ag, but only 30–45 U/ml of VWF:CB and 40–50 U/ml of VWF:RCo (thus, CB/Ag ratio around 0.5–0.6 and RCo/Ag ratio around 0.6–0.7). Study determined that FVIII:C and VWF:RCo levels were similar to manufacturer assigned levels. Some loss of the high molecular weight (HMW) multimers was observed, together with an intense low molecular weight (LMW) VWF band consistent with some reduction or proteolysis of HMW VWF. All three lots of Humate/Haemate contained in the vicinity of 23–32 U/ml of FVIII:C, 70–105 U/ml of VWF:Ag, 50–90 U/ml of VWF:CB and VWF:RCo (i. e. CB/Ag ratio around 0.6–0.9 and RCo/Ag ratio around 0.6–1.1). Study-determined FVIII:C and VWF:RCo levels were similar to manufacturer-assigned levels. The LMW multimer band seen with AHF HP was also observed with Humate/Haemate. All three lots of Biostate contained in the vicinity of 40–55 U/ml of FVIII:C, 105–170 U/ml of VWF:Ag, 90–150 U/ml of VWF:CB, and 90–135 U/ml of VWF:RCo (i. e. CB/Ag and RCo/Ag ratios around 0.7–1.0). Study-determined FVIII:C levels were similar to manufacturer-assigned levels. The LMW multimer band seen with AHF HP was not observed with Biostate. The defined pattern of increasing CB/ Ag from AHF HP to Humate/Haemate and Biostate was consistently observed in study data from each of the five laboratories. In conclusion, study findings indicate some differences in the retention of functional/ HMW VWF between factor concentrates, and this is expected to have significant implications in terms of clinical efficacy for therapy in VWD.
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Elder, S. A., and M. S. Korman. "Laboratory experiments in the acoustics course at the U. S. Naval Academy." Journal of the Acoustical Society of America 94, no. 3 (September 1993): 1854. http://dx.doi.org/10.1121/1.407679.
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LI, Liping, Junying TANG, Liang ZHAO, Songxin MA, Ying CHEN, Ying WANG, Yuhe YANG, and Xia ZUO. "Application of U-G-S Model in Collaborative Innovation for Chemistry Laboratory Education." University Chemistry 33, no. 4 (2018): 1–6. http://dx.doi.org/10.3866/pku.dxhx201709025.
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Stark, N., A. E. Hay, R. Cheel, L. Zedel, and D. Barclay. "Laboratory Measurements of Coarse Sediment Bedload Transport Velocity Using a Prototype Wideband Coherent Doppler Profiler (MFDop)." Journal of Atmospheric and Oceanic Technology 31, no. 4 (April 1, 2014): 999–1011. http://dx.doi.org/10.1175/jtech-d-13-00095.1.
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Abstract A prototype wideband coherent Doppler profiler (MFDop) was tested for measuring bedload velocity of different gravel and coarse-sand-sized fractions (d = 1–32 mm) in the laboratory. The sediment was spread out on a smooth-surface tray, and motion was initiated by tilting the tray at angles of α = 20°–39° from the horizontal. Particle velocities downslope (u), cross slope (υ), and vertical to the tray (w) were determined for different MFDop parameter settings, such as monostatic/bistatic configuration, acoustic beam angle, and pulse length. Video observations of bed particle velocity were made for comparison to the acoustic measurements. Velocities estimated using the MFDop equal to, on average, 71%–74% of the velocities determined using the video observations. Standard deviations ranged from 21% to 35%, including observed irregular motion. Three stages of sediment motion were observed: (i) single particles moving with u ≤ 5 cm s−1, (ii) varying motion of particles and particle groups with predominantly 5 cm s−1 ≤ u ≤ 20 cm s−1, and (iii) fast sheetlike motion with u ≥ 20 cm s−1. The cross-slope velocity υ and the vertical velocity w were significantly smaller than u, hinting at slipping as the major particle motion rather than rolling or saltation. Comparisons between MFDop and video-determined velocities showed good agreement. Standard deviations for the MFDop velocity estimates ranged from 22% to 35%. The trials with different gravelly sediments and coarse sand revealed a significant influence of grain size, as well as grain shape impacting the initiation of sediment transport and transport velocities.
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Baldovin, Tatjana, Irene Amoruso, Fabrizio Caldara, Alessandra Buja, Vincenzo Baldo, Silvia Cocchio, and Chiara Bertoncello. "Microbiological Hygiene Quality of Thermal Muds: A Pilot Study in Pelotherapy Facilities of the Euganean Thermal District (NE Italy)." International Journal of Environmental Research and Public Health 17, no. 14 (July 13, 2020): 5040. http://dx.doi.org/10.3390/ijerph17145040.
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Evaluation of hygienic aspects of thermal mud microbiology is still neglected. This study evaluates the microbiological hygiene quality of thermal muds, providing a comprehensive assessment of the whole mud cultivation chain. Maturing mud, peloid and used mud samples were collected twice in a year from 30 SPAs of the Euganean Thermal District, NE Italy. Samples were processed with an ad hoc laboratory method. The following indicator parameters were assessed: Total Count at 22, 37 and 55 °C; total coliforms; Escherichia coli; enterococci; Staphylococcus aureus; Pseudomonas aeruginosa; sulfite-reducing clostridia; dermatophytes. Statistical significance of differences between the two sampling campaigns and correlation between temperature and indicator parameters were evaluated. One-hundred eighty samples were analyzed. Widespread presence of environmental species was found, as well as hints of possible microorganism transfer from the patient’s skin to the mud. Proper setting of thermal water temperature resulted critical, in terms of hygienic quality. Although optimal maturation should be granted (thermal water at 30–42 °C), a pasteurization step at 60–65 °C is strongly recommended to sanitize peloids before pelotherapy. Facilities re-using thermal muds should also implement a regeneration step at ≥65 °C. Core evaluation of thermal mud hygienic quality could encompass the following guidelines: absence (i.e., 0 colony forming units (CFU)/g) of E. coli, P. aeruginosa, S. aureus and dermatophytes.
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YA. BERDNIKOV, A., YA A. BERDNIKOV, M. FABER, A. N. IVANOV, V. A. IVANOVA, A. V. NIKITCHENKO, and N. I. TROITSKAYA. "ON NONLEPTONIC DECAYS OF THE Λ0-HYPERON IN THE EFFECTIVE QUARK MODEL WITH CHIRAL U(3)×U(3) SYMMETRY." International Journal of Modern Physics A 22, no. 10 (April 20, 2007): 1835–47. http://dx.doi.org/10.1142/s0217751x07036373.
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Within the effective quark model with chiral U (3) × U (3) symmetry we calculate the S-wave and P-wave amplitudes and the partial widths of the nonleptonic decays of the Λ0-hyperon, Λ0 → pπ- and Λ0 → nπ0. The theoretical results agree well with the experimental data. The angular distributions of the decay rates in dependence on the polarizations of baryons are analyzed both in the laboratory frame and in the rest frame of the Λ0-hyperon.
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STAVRIC, S., and J. Y. D'AOUST. "Undefined and Defined Bacterial Preparations for the Competitive Exclusion of Salmonella in Poultry - A Review." Journal of Food Protection 56, no. 2 (February 1, 1993): 173–80. http://dx.doi.org/10.4315/0362-028x-56.2.173.
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During the past two decades, there have been many studies on the efficacy of competitive exclusion for the control of Salmonella in poultry. Undefined preparations of cultured fecal or cecal microflora generally reduce the prevalence of infected chicks upon challenge with a standard dose of Salmonella under laboratory conditions; in contrast, results under field conditions are more variable. The protective capacity of undefined cultures can be affected by several factors including the source of microflora, method for protective culture administration, presence of poultry feed additives, in-laboratory or natural environmental challenge, and hygienic practices on the farm. The formulation of effective defined cultures is most difficult because of insufficient knowledge on the underlying protective mechanism(s) and interactions between gut microflora. Defined cultures are less effective than undefined cultures under laboratory conditions and afford little protection against natural Salmonella challenge; their potency decreases upon storage and manipulation of single or mixtures of defined culture isolates.
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Gupta, Nalini, Vikrant S. Bhar, Arvind Rajwanshi, and Vanita Suri. "Unsatisfactory rate in liquid-based cervical samples as compared to conventional smears: A study from tertiary care hospital." CytoJournal 13 (June 10, 2016): 14. http://dx.doi.org/10.4103/1742-6413.183831.
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Background: Developed countries adopted liquid-based cytology (LBC) cervical cytology, partly because of its lower proportions of unsatisfactory (U/S)/inadequate samples. This study was carried out to evaluate effect on the rate of U/S samples after introduction of LBC in our laboratory. Materials and Methods: An audit of U/S cervical samples was performed, which included split samples (n = 1000), only conventional Pap smear (CPS) smears (n = 1000), and only LBC samples (n = 1000). The smears were reviewed by two observers independently, and adequacy for the samples was assessed as per The Bethesda System 2001. The reasons for U/S rate in split samples were categorized into various cytologic and/or technical reasons. Results: U/S rate was far less in only LBC samples (1.2%) as compared to only CPS (10.5%) cases. Cases in the satisfactory but limited category were also less in only LBC (0.4%) as compared to only CPS (3.2%) samples. The main reasons for U/S smears in split samples were low cell count (37.2% in CPS; 58.8% in LBC). The second main reason was low cellularity with excess blood and only excess blood in CPS samples. Conclusion: There was a significant reduction of U/S rate in LBC samples as compared to CPS samples, and the difference was statistically significant. The main cause of U/S samples in LBC was low cellularity indicating a technical fault in sample collection. The main cause of U/S rate in CPS was low cellularity followed by low cellularity with excess blood. Adequate training of sample takers and cytologists for the precise cell count to determine adequacy in smears can be of great help in reducing U/S rate.
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BABAR, AMIR MOHAMMAD, Mohammad Hanif Mengal, CHANDI KAPOOR, Ghulam Sarwar Pirkani, and MOHAMMAD IQBAL. "VIBRIO CHOLERAE." Professional Medical Journal 16, no. 03 (September 10, 2009): 380–83. http://dx.doi.org/10.29309/tpmj/2009.16.03.2800.
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b j e c t i v e : To isolate the etiological agent of diarrheal outbreak, identification, antibiogram of isolated bacteria. P a t i e n t s a ndM e t h o d s : Stool samples from patients and water samples from reservoir of water collected in transport media. Culture and sensitivity test wereperformed in Microbiology Laboratory of Bolan Medical Complex Hospital Quetta. The isolated strain was confirmed by National Institute ofHealth Laboratory Islamabad and Agha Khan University hospital laboratory Karachi. The outbreak was controlled by preventive measures.R e s u l t s : More than five thousand people affected in the outbreak, including all age and both sexes. Twenty three deaths (0.4%) occurred inthis outbreak. The stool samples from patients and from 5 water reservoir tanks collected for analysis of etiological agent responsible for theoutbreak. The stool and water samples revealed isolation of Vibrio cholerae Inaba, El Tor, which was sensitive to Ampicillin, Ciprofloxacin,Tetracycline, Doxycyline and intermediate to Choloramphenicol and Erythromycin. Resistant to Nalidixic Acid Polymaxin B, and Cotrimaxazole.C o n c l u s i o n : The Vibrio cholerae Inaba, El Tor was the causative agent of this outbreak and the first outbreak which occurred inBalochistan due to Vibrio cholerae Inaba, El Tor.
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Philippé, J., G. Dooijewaard, F. Offner, P. Turion, G. Baele, and G. Leroux-Roels. "Granulocyte Elastase, Tumor Necrosis Factor-α and Urokinase Levels as Prognostic Markers in Severe Infection." Thrombosis and Haemostasis 68, no. 01 (1992): 019–23. http://dx.doi.org/10.1055/s-0038-1656310.
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SummaryWe have examined the prognostic value of the levels in the blood of granulocyte elastase-α1-proteinase inhibitor (E-α1-PI) complex, tumor necrosis factor-α (TNF-α) and urokinase-type plasminogen activator (u-PA) in 35 patients with severe infection upon admission to an Intensive Care Unit. Fourteen patients died.No differences for E-α1-PI complex were found between survivors and nonsurvivors, but in all patients the levels on admission were eight-fold higher than the reference value.TNF-α levels, measured by immunoassay, on admission were four times higher in the nonsurvivors than in the survivors (p = 0.0003) and correlated with the severity of the disease (APACHE II score, r = 0.43, p <0.05). TNF-α was not detectable by bioassay.Total u-PA antigen (u-PA Ag), plasmin-activatable single-chain u-PA (scu-PA) and inactive, nonactivatable u-PA (u-PA#) were on admission all two-fold higher in the nonsurvivors (p = 0.0006, 0.003 and 0.0003, respectively), while normal in the survivors. In both, survivors and nonsurvivors, the ratio between scu-PA and u-PA Ag was significantly decreased (p <0.001, compared to a reference group of healthy volunteers), indicative for enhanced conversion of scu-PA to active two-chain u-PA (tcu-PA) and inactive u-PA# during severe infectious disease. tcu-PA was detected in nine of the 35 patients, while virtually undetectable in controls. scu-PA correlated with the Child-Pugh score on admission (r = 0.42, p <0.05). TNF-α correlated with u-PA Ag (r = 0.38, p <0.05) and with u-PA# (r = 0.47, p <0.01).In a stepwise logistic regression analysis, documentation of infection and plasma levels of u-PA Ag contributed most significantly to prediction of patient outcome. Serum levels of TNF-α did not. These results suggest that, in addition to a number of other clinical and laboratory parameters, u-PA Ag can be used as a prognostic marker in patients with severe infection admitted to an Intensive Care Unit.
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Tripodi, Armando, Rogier M. Bertina, Jacqueline Conard, Ingrid Pabinger, Nuria Sala, and Pier Mannuccio Mannucci. "Multicenter Evaluation of Three Commercial Methods for Measuring Protein S Antigen." Thrombosis and Haemostasis 68, no. 02 (1992): 149–54. http://dx.doi.org/10.1055/s-0038-1656340.
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SummaryThis collaborative study was designed to assess the performance of commercial methods for protein S (PS) antigen measurement. Twenty-five different samples were distributed deep-frozen (24 plasmas) or lyophilized (one plasma) to five laboratories. They were analyzed blind in each laboratory by the method used locally and by three commercial methods which included two electroimmunoassays (EIA), Asseraplate-PS (Diagnostica Stago), Rellplate-S (American Diagnostica) and an ELISA system, Asserachrom-PS (Diagnostica Stago). 1. Reproducibility. Average between-laboratory coefficients of variation were 15.4%, 17.6% and 25.3% for Asserachrom-PS, Asseraplate-PS and Rellplate-S. 2. Specificity. Results of all methods showed that PS is underestimated when C4b binding protein is high. This influence was particularly evident for the ELISA Asserachrom-PS and disappeared when the antibody-antigen incubation period was prolonged to overnight. 3. Sensitivity. In all laboratories ELISA detected even the lowest PS concentration (4 U/dl), whereas the two EIAs were less sensitive (lower detection limit 14 U/dl). All methods and laboratories correctly diagnosed a plasma sample from a PS congenitally deficient patient. Conclusions. This study shows that better standardization of PS immunoassays is necessary to improve accuracy and reduce interlaboratory variability before a candidate plasma standard can be successfully calibrated in an international collaborative study.
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Kahma, Kimmo K., and Mark A. Donelan. "A laboratory study of the minimum wind speed for wind wave generation." Journal of Fluid Mechanics 192 (July 1988): 339–64. http://dx.doi.org/10.1017/s0022112088001892.
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The minimum wind speed for wind wave generation has been investigated in a laboratory wind-wave flume using a sensitive slope gauge to measure the initial wavelets about 10 μm high. The growth at very low wind speeds was higher than predicted by the viscous shear-flow instability theory. Assuming that the growth is exponential, the inception wind speed at which the growth rate becomes positive can be defined. It occurred at (friction velocity) u* ≈ 2 cm/s, somewhat lower than the u* ≈ 4–5 cm/s predicted by shear-flow instability theory. However, the observed growth rates were close to the theory at higher wind speeds when the waves were higher than 1 mm. The effect of temperature on the wind speed at which the waves become readily visible is shown to be appreciable and in keeping with the temperature dependent viscous damping. Other sources of growth are discussed. Our estimates show that the Phillips resonance mechanism might be sufficiently effective to generate the observed growth at very low wind speeds.
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Leykin, I. A., M. A. Donelan, R. H. Mellen, and D. J. McLaughlin. "Asymmetry of wind waves studied in a laboratory tank." Nonlinear Processes in Geophysics 2, no. 3/4 (December 31, 1995): 280–89. http://dx.doi.org/10.5194/npg-2-280-1995.
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Abstract. Asymmetry of wind waves was studied in laboratory tank tinder varied wind and fetch conditions using both bispectral analysis of wave records and third-order statistics of the surface elevation. It is found skewness S (the normalized third-order moment of surface elevation describing the horizontal asymmetry waves) varies only slightly with the inverse wave u*/Cm (where u* is the air friction velocity and Cm is phase speed of the dominant waves). At the same time asymmetry A, which is determined from the Hilbert transform of the wave record and characterizes the skewness of the rate of change of surface elevation, increase consistently in magnitude with the ratio u*/Cm. This suggests that nonlinear distortion of the wave profile determined by the degree of wind forcing and is a sensitive indicator of wind-wave interaction processes. It is shown that the asymmetric profile of waves can described within the frameworks of the nonlinear nonspectral concept (Plate, 1972; Lake and Yuen, 197 according to which the wind-wave field can be represented as a coherent bound-wave system consisting mainly of dominant component w. and its harmonics propagating with the same speed C. , as observed by Ramamonjiaris and Coantic (1976). The phase shift between o). harmonics is found and shown to increase with the asymmetry of the waves.
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Robinson, Jeff H., Ian Dodd, Ashiq Esmail, Harry Ferres, and Barbara Nunn. "Slow Clearance of Acylated, Hybrid Thrombolytic Enzymes." Thrombosis and Haemostasis 59, no. 03 (1988): 421–25. http://dx.doi.org/10.1055/s-0038-1647508.
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SummaryTwo hybrid plasminogen activators, plasmin A-chair/t-PA Bchain and plasmin A-chain/u-PA B-chain have been synthestzed and purified in sufficient yield to permit measurement of clearance in small laboratory animals. Each hybrid enzyme was reversibly acylated at the active centre to allow the pharmacokinetic profile to be followed using an activity-based method without interference from plasma inhibitors. The acylated plasmin/u-PA hybrid had a clearance half-life (t½) in guinea pigs of approximately 80 min, whereas acyl u-PA had a t½ of 3 min. The pharmacokinetic profile of the acylated plasmin/t-PA hybrid was measured in guinea pigs, rats and rabbits; the half-lives in all three species were 60–80 min compared to half-lives of acylated, native t-PA that were in the range 0.5–1.0 min. Thus, plasmin A-chaincontaining, acylated hybrid enzymes are cleared some 30- to 100-fold more slowly than the acylated parent activators.
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Jovičić, Snežana. "Biochemical Aspects, Laboratory Diagnosis and Follow-Up of High Blood Cholesterol: NCEP ATP III Guidelines." Journal of Medical Biochemistry 27, no. 1 (January 1, 2008): 64–85. http://dx.doi.org/10.2478/v10011-007-0044-2.
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Biohemijski Aspekti, Laboratorijska Dijagnoza I Praćenje Povišene Koncentracije Holesterola: PreporukeNCEP ATP IIITreći izveštaj ekspertske grupe o detekciji, evaluaciji i tretmanu povišene koncentracije holesterola u odraslih (Adult Treatment Panel III, ATP III) predstavlja ažuriran klinički vodič Nacionalnog programa edukacije o holesterolu (National Cholesterol Education Program, NCEP), o određivanju holesterola i zbrinjavanju osoba s povišenom koncentracijom holesterola u serumu. Pored toga što preporučuje intenzivan tretman pacijenata sa koronarnom srčanom bolešću (coronary heart disease/CHD), važna karakteristika ATP III je težište na primarnoj prevenciji kod osoba sa više prisutnih faktora rizika. ATP III nastavlja da identifikuje povišene koncentracije LDL holesterola kao primarni cilj terapije za snižavanje holesterola. Osnovni princip prevencije je da se intenzitet terapije prilagođava apsolutnom riziku za CHD svake osobe pojedinačno. Procena rizika podrazumeva određivanje LDL holesterola u sklopu analize lipoproteina i identifikaciju pratećih determinanti rizika (prisustvo ili odsustvo CHD, drugih kliničkih oblika aterosklerotske bolesti i dijabetesa, pušenje, hipertenzija, niska koncentracija HDL holesterola, porodična anamneza prevremene pojave CHD, starost). U kategoriji najvišeg rizika nalaze se osobe sa CHD i CHD ekvivalentima rizika, čiji je apsolutni rizik od pojave srčane smrti ili nefatalnog infarkta miokarda u narednih 10 godina ≥20%. Drugu kategoriju čine osobe sa dva ili više faktora rizika kod kojih je 10-godišnji rizik <20%. Apsolutni rizik se procenjuje na osnovuFraminghamrizik skora. U trećoj kategoriji su osobe sa jednim ili nijednim faktorom rizika. Definisane su preporučene koncentracije LDL holesterola za svaku kategoriju i postižu se korekcijom ishrane i/ili farmakoterapijom. Evropske preporuke za prevenciju kardiovaskularne bolesti (cardiovascular disease, CVD) u kliničkoj praksi preporučuju upotrebu SCO-RE (Systematic COronary Risk Evaluation) tablica za procenu rizika za pojavu CVD, koje podrazumevaju apsolutnu verovatnoću za fatalan ishod CVD u toku 10 godina. Cilj ovog rada je predstavljanje delova NCEP ATP III i evropskih preporuka značajnih za njihovu implementaciju u laboratorijsku praksu.
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Sancho, L. G., B. Schroeter, and F. Valladares. "Photosynthetic Performance of Two Closely Related Umbilicaria Species in Central Spain: Temperature as a Key Factor." Lichenologist 29, no. 1 (January 1997): 67–82. http://dx.doi.org/10.1006/lich.1996.0061.
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AbstractNet photosynthesis (NP) and dark respiration (DR) of thalli of the lichen species Umbilicaria grisea and U. freyi growing together in the same habitat the Sierra de Guadarrama, central Spain, were measured under controlled conditions in the laboratory and under natural conditions in the field over a range of photosynthetic photon flux densities (PPFD), thallus temperatures and thallus water contents. Laboratory experiments revealed that the photosynthetic response to PPFD at optimum thallus water content is very similar in both species. The light compensation points of NP increased from PPFD of c. 20 µmol m−2 s−1 at 0°C up to c. 100 µmol m−2 s−1 PPFD at 25°C. In both species light saturation was not reached up to 700 µmol m−2 s−1 PPFD except at 0°C. By contrast, the temperature dependence of CO2 gas exchange differed substantially between U. grisea and U. freyi. Both species gave significant rates at 0°C. Optimal temperatures of NP were always higher in U. grisea at various PPFD levels if the samples were kept at optimal thallus water content. NP showed maximal rates at 95% dw in U. grisea and 110% dw in U. freyi respectively. In U. grisea a much stronger depression of NP was observed with only 5% of maximal NP reached at 180% dw. At all PPFD and temperature combinations U. freyi showed higher rates of NP and more negative rates of DR if calculated on a dry weight basis. This was also true under natural conditions at the same site, when U. freyi was always more productive than U. grisea. The differences in the photosynthetic response to temperature between both species correlated well with the different distribution patterns of both species. The possibility of genetic control of the physiological performance of these species and its influence on their distribution patterns and autecology is discussed.
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Bertina, R. M., A. van Wijngaarden, J. Reinalda-Poot, S. R. Poort, and V. J. J. Bom. "Determination of Plasma Protein S - The Protein Cofactor of Activated Protein C." Thrombosis and Haemostasis 53, no. 02 (1985): 268–72. http://dx.doi.org/10.1055/s-0038-1661291.
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SummaryProtein S, an important cofactor of activated protein C, and C4b-binding protein were purified from human plasma. Specific antibodies against the purified proteins were raised in rabbits and used for the development of immunologic assays for these proteins in plasma: an immunoradiometric assay for protein S (which measures both free protein S and protein S complexed with C4b-binding protein) and an electroimmunoassay for C4b- binding protein. Ranges for the concentrations of these proteins were established in healthy volunteers and patients using oral anticoagulant therapy. A slight decrease in protein S antigen was observed in patients with liver disease (0.78 ± 0.25 U/ml); no significant decrease in protein S was observed in patients with DIC (0.95 ± 0.25 U/ml).Criteria were developed for the laboratory diagnosis of an isolated protein S deficiency
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Kaduk, James A., and Joel Reid. "Typical values of Rietveld instrument profile coefficients." Powder Diffraction 26, no. 1 (March 2011): 88–93. http://dx.doi.org/10.1154/1.3548128.
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GSAS instrument parameters are tabulated for a variety of laboratory and synchrotron diffractometers to give users an idea of the typical ranges of profile parameters when they generate their own instrument parameter files. For modern high-resolution laboratory diffractometers, the parameters fall in the ranges 0<U<3, V=0, 0<W<4, 1<X<3, 0<Y<3, 1<asym<3, and 0<S/L<0.03. For synchrotron diffractometers, the parameters fall in the ranges 0<U<1.2, −1<V<0, 0<W<1, 0<X<1, 0<Y<1, 0<asym<0.5, 0<S/L<0.001, and 0<H/L<0.007. FULLPROF equivalents are also reported. The factors which are convoluted together to generate the instrument profile are described.
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Kim, Jinho. "Case Study of Space Characteristics and Layout to Promote Communication within the Laboratory Facility - Focusing on the Case of U. S. Laboratory Facility -." Journal of the Korean Institute of Interior Design 30, no. 3 (June 30, 2021): 54–64. http://dx.doi.org/10.14774/jkiid.2021.30.3.054.
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Beer, T. "The Speed of a Fire Front and Its Dependence on Wind-Speed." International Journal of Wildland Fire 3, no. 4 (1993): 193. http://dx.doi.org/10.1071/wf9930193.
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The results of a number of laboratory tests of wind-driven fires indicate the existence of a characteristic wind speed, U'. The form of the fire spread (V) as a function of mid-flame wind speed (U) differs above and below this characteristic speed. The scatter in field data is so great that it is difficult to confirm this result for field data. However, expressions of the form: V/V0 -1 = α(U/U')0.5 U/U' < 1 and V/V0 -1 = α(U/U')3 U/U' > 1 with U' = 2.5 m s-1 perform in a similar manner to existing models. For many fuel types α = 15. A difficulty with existing fire spread models is the measurement and definition of V0, the no-wind rate of spread. It can hardly ever be measured in the field and has to be inferred from analytical formulae, or by extrapolating measured data. The value of a depends on the method used estimate V0.
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Zhou, Ouyang, Zhang, Wei, Tang, Ma, Tan, Zhu, Teklebrhan, and Han. "Sweet Corn Stalk Treated with Saccharomyces Cerevisiae Alone or in Combination with Lactobacillus Plantarum: Nutritional Composition, Fermentation Traits and Aerobic Stability." Animals 9, no. 9 (August 23, 2019): 598. http://dx.doi.org/10.3390/ani9090598.
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This study examined the effects of a high-dose Saccharomyces cerevisiae inoculant alone or jointly with Lactobacillus plantarum on nutrient preservation, fermentation quality, and aerobic stability of sweet corn stalk silage. Fresh stalks (231 g dry matter (DM)/kg) were chopped and subjected to the following treatments: (1) deionized water (Uninoculated; U); (2) S. cerevisiae at 1 × 108 cfu/g of fresh forage (S); and (3) S. cerevisiae at 1 × 108 cfu/g plus L. plantarum at 1 × 105 cfu/g (SL). Treated stalks were ensiled in 5-litre laboratory silos for 30, 60, and 90 d. The S and SL silages had a greater (p < 0.001) pH and greater crude protein, ammonia nitrogen/total nitrogen, neutral detergent fibre, acid detergent fibre, and ethanol contents at all three ensiling periods than the U silage. Acetate, propionate and volatile fatty acids in the S and SL silages after 30 and 90 d of ensiling were greater (p < 0.05) than those in the U silage, but they were lower (p < 0.05) in the S and SL silages than in the U silage after 60 d. The lactate and V-score of the S and SL silages were lower (p < 0.001) than those of the U silage at all three ensiling periods. Compared with the U group, the aerobic stability of the S silage after 90 d of ensiling decreased (p < 0.05), and the aerobic stability of the SL silage was unaffected (p > 0.05). Overall, the quality of sweet corn stalk silage was not improved by inoculation with 108 cfu/g of S. cerevisiae alone or in combination with 1 × 105 cfu/g of L. plantarum.
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Emerson, Craig W. "Influence of Sediment Disturbance and Water Flow on the Growth of the Soft-Shell Clam,Mya arenariaL." Canadian Journal of Fisheries and Aquatic Sciences 47, no. 9 (September 1, 1990): 1655–63. http://dx.doi.org/10.1139/f90-189.
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The importance of sediment disturbance and water flow to the production of the soft-shell clam, Mya arenaria, was assessed in laboratory flumes by measuring growth rates of clams exposed to a gradation of bed shear stress, free-stream velocity, and frequency and depth of sediment disturbance over a 10-m period. In the absence of sediment disturbance, growth of soft-tissue was directly proportional to both free-stream (U) and shear (U*) velocity (r2 = 0.64 and 0.72, respectively). It was suggested that increased organic seston flux linked higher water flow to higher growth. In all treatments, maximum growth rates were observed with daily disturbance of the top centimeter of sediment. No level of disturbance resulted in growth rates lower than those of undisturbed clams in low flow (U = 0.4 cm∙s−1, U* = 0.1 cm∙s−1). The stimulation of growth under maximum sediment disturbance was removed when U exceeded ~3 cm∙s−1(U* = 0.7 cm∙s−1). An energy budget for M. arenaria indicated that the amount of organic material suspended during sediment disturbance was insufficient to account for the increased growth in clams subjected to high levels of disturbance. It was suggested that the sediment disturbance associated with intense clam harvesting, and changes in local hydrography resulting from coastal development, may be responsible for some of the unexplained growth variation in commercial clam stocks.
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Murdock, Paul J., Barry J. Woodhams, Kathy B. Matthews, K. John Pasi, and Alison H. Goodall. "von Willebrand Factor Activity Detected in a Monoclonal Antibody-based ELISA: an Alternative to the Ristocetin Cofactor Platelet Agglutination Assay for Diagnostic Use." Thrombosis and Haemostasis 78, no. 04 (1997): 1272–77. http://dx.doi.org/10.1055/s-0038-1657727.
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SummaryThe monoclonal antibody RFF-VIII:R/1 recognises an epitope on von Willebrand factor involved in its interaction with GPIbα. A two-site, solid phase ELISA has been established using RFF-VIII:R/1 as the solid-phase, capture antibody and an enzyme-conjugated, polyclonal antibody to human VWF, which provides an assay for VWF functional activity with a detection limit of 0.5 U/dl VWF and an interassay %CV<10. Plasma from 192 VWD patients (48 studied retrospectively; 144 prospectively) showed VWF levels of <50 U/dl in type 1 patients (n = 156), <25 U/dl in type 2A (n = 26) and <35 U/dl in type 2B (n = 8) which, in type 1 and 2A patients, correlated with RiCoF activity (r >0.82). In plasma from patients with type 1 VWD values of VWF in the Mab-based ELISA were similar to levels of VWF:Ag measured in a polyclonal antibody-based ELISA (r >0.87) but were significantly lower than VWF:Ag in type 2A and 2B plasmas (p <0.0005), allowing discrimination of variant VWD. The Mab-based ELISA has advantages of sensitivity and reproducibility over the RiCoF assay to measure VWF activity and can be used to analyse stored samples. In conjunction with an ELISA for VWF:Ag and VWF multimer analysis, it provides a reliable method, for the laboratory diagnosis of VWD.
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Galimova, Irina, Rita Yunusova, Irina Usmanova, Larisa Gerasimova, Yigal Granot, Yulia Bortsova, Amina Ishmukhametova, Lilia Kuznetsova, Emil Muratov, and Diana Usmanova. "FEATURES OF CLINICAL AND LABORATORY PARAMETERS AT THE PATIENS WITH RECURRENT ORAL AFTS AND CONDOMITANT ACID-DEPENDENT DISEASES OF THE GASTROINTESTINAL TRACT." Actual problems in dentistry 16, no. 3 (November 5, 2020): 23–29. http://dx.doi.org/10.18481/2077-7566-2020-16-3-23-29.
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Subject. Some features of the clinical picture, hygienic and microbiological state of the oral cavity, acidity and free-radical oxidation of the oral fluid in patients with recurrent aphthates on the background of acid-dependent diseases of the gastrointestinal tract are considered.
The aim is to assess the relationship between clinical and laboratory parameters in patients with recurrent oral aphthae associated with acid-dependent diseases of the gastrointestinal tract.
Methodology. A comprehensive clinical and laboratory examination of 58 young people with revealed recurrent aphthae of the oral cavity against the background of acid-dependent diseases of the gastrointestinal tract was carried out. The level of oral hygiene was assessed using the ONI-s index, the state of free-radical oxidation of the oral fluid - the "Chemilumimer-003" device, individual representatives of the normal flora were identified by inoculating the contents from the surface of aphthous elements on special differential diagnostic media of the HiCrome series. The acidity of the oral fluid was determined using a universal indicator litmus paper pH-1-14, short-term intragastric pHmetry was performed directly during fibrogastroduodenoscopy.
Results. In 46.4 % of those examined, recurrent aphthae were found on the oral mucosa. In persons with chronic gastritis and duodenitis, the frequency of recurrences once a year was 37.9 %, 2-3 times a year ― 62.0, with the presence of chronic pancreatitis against the background of hyperacid gastric secretion ― 44.8 and 55.2, respectively. In patients with recurrent aphthae, a low level of oral hygiene, a violation of its microbiome, and a change in the acidity of the oral fluid were revealed.
Conclusions. The presence of recurrent aphthae complicates individual oral hygiene, because accompanied by severe pain and paresthetic symptoms. This is manifested by an increase in the ONI-S index and a disturbance in the state of the normobiome in the form of an increase in the growth of resident microflora against the background of changes in the acidity of the oral fluid. Chemiluminescence indices correlate with the hygienic state of the oral cavity, qualitative changes in the normobiota and pH of the oral fluid in the studied clinical groups.
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KOSTIK, M. M., M. M. MNUSKINA, I. N. MAKAROVA, D. A. KUZ'MINA, L. A. ShchEPLYaGINA, and V. I. LARIONOVA. "KOSTNAYa MASSA I KOSTNYY METABOLIZM U DETEY S YuVENIL'NYM IDIOPATIChESKIM ARTRITOM." Osteoporosis and Bone Diseases 14, no. 3 (December 15, 2011): 19–23. http://dx.doi.org/10.14341/osteo2011319-23.
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This study describes bone metabolism in children withjuvenile idiopathic arthritis (JIA), association between disturbances of bone metabolism with inflammatory activity, juvenile arthritis disease course and therapy in 198 children. Low bone mineral density (BMD) for chronological age was detected by dual-energy X-ray absorptiometry of lumbar spine L1-L4 (densitometer Hologic QDR 4500C, with pediatric reference database) than Z -score < -2 SD in 36 children (18,2%), in 18 girls (15,5%) and in 18 boys (21,9%). Girls with low BMD received glucocorticoids (GCS) in 66,7 % cases, and girls with normal BMD received it in 26,5% cases (р=0,002). Girls with low BMD had lower height, weight, earlier age of disease onset and higher clinical and laboratory parameters of arthritis activity. Girls with low BMD had higher osteocalcin and tendency to decreased parathyroid hormone levels compared to the girls with normal BMD. Children who received GCS had specific stereotypic changes: boys had significantly lower bone mineral density and total Ca and girls had significantly lower bone mineral content and BMD (g/cm2 and Z-score), total Са, non-organic phosphate and total alkaline phosphatase activity. Patients with systemic arthritis had significantly lower mineralization and bone metabolism turnover compared to children with oligoarticular and polyarticular JIA subtypes. Independent predictors of skeletal mineralization were age onset f JIA (р<0,0001), duration of the disease (p<0,0001), hemoglobin level (р=0,004), total calcium level (р=0,024), a2-globulins level (р=0,046). Independent predictors of low BMD were physician’s assessment VAS (р=0,024), C-reactive protein (р=0,04), inorganic phosphate (р=0,05). Systemic glucocorticoids exposure elevated the risk of low BMD for chronological age realization in JIA patients (OR=1,96, 95%CI=0,76-5,05). Enhanced risk of low BMD was in polyarthicular (OR=2,53, 95%CI=0,66-9,65) and systemic JIA (OR=3,16, 95%CI=0,73-13,76). Thus, parameters of inflammation have negative influence on bone metabolism velocity, linear growth and accordingly bone mineralization. Described factors explain heterogeneity of mineralization disorders.
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Romero, Leonel, W. Kendall Melville, and Jessica M. Kleiss. "Spectral Energy Dissipation due to Surface Wave Breaking." Journal of Physical Oceanography 42, no. 9 (January 20, 2012): 1421–44. http://dx.doi.org/10.1175/jpo-d-11-072.1.
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Abstract A semiempirical determination of the spectral dependence of the energy dissipation due to surface wave breaking is presented and then used to propose a model for the spectral dependence of the breaking strength parameter b, defined in the O. M. Phillips’s statistical formulation of wave breaking dynamics. The determination of the spectral dissipation is based on closing the radiative transport equation for fetch-limited waves, measured in the Gulf of Tehuantepec Experiment, by using the measured evolution of the directional spectra with fetch, computations of the four-wave resonant interactions, and three models of the wind input source function. The spectral dependence of the breaking strength is determined from the Kleiss and Melville measurements of the breaking statistics and the semiempirical spectral energy dissipation, resulting in b = b(k, cp/u*), where k is the wavenumber and the parametric dependence is on the wave age, cp/u*. Guided by these semiempirical results, a model for b(k, cp/u*) is proposed that uses laboratory data from a variety of sources, which can be represented by b = a(S − S0)n, where S is a measure of the wave slope at breaking, a is a constant, S0 is a threshold slope for breaking, and 2.5 < n < 3 is a power law consistent with inertial wave dissipation scaling and laboratory measurements. The relationship between b(S) in the laboratory and b(k) in the field is based on the relationship between the saturation and mean square slope of the wave field. The results are discussed in the context of wind wave modeling and improved measurements of breaking in the field.
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Timsina, Roshan, Bivek Timalsina, and Anjana Singh. "Screening of erm Gene of Inducible Clindamycin Resistant Staphylococcus aureus." Journal of Institute of Science and Technology 24, no. 2 (December 31, 2019): 39–43. http://dx.doi.org/10.3126/jist.v24i2.27255.
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Antibiotic resistance exhibited by Staphylococcus aureus is a growing global concern. This work was undertaken to determine the prevalence rate of inducible clindamycin resistant S. aureus in nasal sample and detect ermB gene in the isolates with inducible clindamycin resistance. Nasal swabs were collected from the school children and cultured on Mannitol Salt Agar (MSA) and Blood Agar (BA) for observation of colony morphology. Gram staining and biochemical test (catalase, oxidase, O-F and coagulase) were performed for further identification of the bacteria. The Kirby-Bauer disc diffusion method using a cefoxitin disc (30 μg) was used to detect methicillin resistant S. aureus (MRSA). All, the MRSA isolates were tested for ermB gene by PCR amplification. Among 64 S. aureus isolates, 17 (26 %) were MRSA. The prevalence of Inducible clindamycin resistant S. aureus (iMLSB) isolates was 23.4 % in the S. aureus isolates. All the isolates of MRSA were resistant to penicillin, while 88.2 % were sensitive to gentamicin. The prevalence of ermB gene was 3.1 % in the total S. aureus isolates and 11.7 % MRSA showed the presence of this gene. Routinely performing a D-test in laboratory will guide the clinicians on the rationale use of clindamycin and improving hygienic practices can reduce the spread of inducible clindamycin resistance.
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BRAR, PARDEEPINDER KAUR, and MICHELLE D. DANYLUK. "Salmonella Transfer Potential during Hand Harvesting of Tomatoes under Laboratory Conditions." Journal of Food Protection 76, no. 8 (August 1, 2013): 1342–49. http://dx.doi.org/10.4315/0362-028x.jfp-13-048.
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Tomato good agricultural practices, mandatory guidelines in Florida, do not have specific regulations for glove use during tomato harvesting. The objective of the research reported here was to evaluate Salmonella transfer from contaminated gloves to tomatoes and vice versa upon single and subsequent touches. Experiments were performed using mature, green, round tomatoes with two types of gloves (reusable and single use) and two hygienic conditions of reusable glove (clean and dirty [fouled with tomato leaves]). The transfer scenarios used during experiments were glove to tomato, tomato to glove, and glove to up to 25 subsequently touched tomatoes. The inoculated surface (6 log CFU per surface), after drying for 24 h, touched the uninoculated surface for 5 s. Salmonella populations from gloves and tomatoes were enumerated on nonselective and selective agar supplemented with 80 μg/ml rifampin. Enrichments were performed when counts fell below the detection limit. The rates of Salmonella transfer to tomatoes during a single touch were similar for single-use and reusable gloves; transfer from tomatoes to gloves was higher to single-use gloves than to reusable gloves under wet (0 h) inoculation conditions. Dirty reusable gloves did not transfer more Salmonella than clean reusable gloves during single contact under any conditions. When a single glove was sequentially touched to multiple tomatoes, clean reusable gloves transferred higher levels of Salmonella to the first few tomatoes touched than did single-use gloves and dirty reusable gloves. As workers' gloves became dirty over time during harvest, the risk of Salmonella transfer to tomatoes did not increase.
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Bielek, Boris, Daniel Szabó, and Milan Lavrinčík. "Transparent Elemental Facade with an Integrated Ventilation Unit for a High-Rise Building – Development and Experimental Verification." Slovak Journal of Civil Engineering 26, no. 4 (December 1, 2018): 66–77. http://dx.doi.org/10.2478/sjce-2018-0030.
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Abstract The article documents the development of a modular transparent elemental facade. The cooperative development was realized in two areas, i.e., the development of facade ventilation units for an under-pressure ventilation system and experimental verification in a laboratory of a facade panel and optimization of its acoustic parameters. The task of controlled ventilation in modern residential buildings is to ensure the optimum quality of the interior environment and fulfill hygienic and thermal technical requirements that guarantee the comfort of the users. The paper discusses the development and experimental verification of atypical vertical ventilation units of an under-pressure controlled ventilation system for a residential high-rise building. A recommended concept for the facade´s details has been developed in relation to the ventilation system. Conceptual designs of alternatives to the air inlet openings of an under-pressure controlled ventilation system for the apartments with an atypical vertical geometry were proposed. An optimized alternative to air inlet openings in the bottom level of a vertical pilaster with the function of an air distribution channel for a ventilation system has been selected and developed. Laboratory experiments have verified the physical properties of the optimized alternative ventilation units of the under-pressure controlled ventilation system in their development cycle. The hydrodynamic regime of the air inlet openings of the controlled ventilation system has been verified by experimental research in a laboratory large rain chamber. The aerodynamic regime of a naturally controlled ventilation system was verified by experimental research in a large laboratory pressure chamber. The acoustic properties of the naturally controlled ventilation system were verified by experimental research in a laboratory´s acoustic chambers. The verified parameters of the ventilation units of the under-pressure controlled ventilation obtained by the experiment were compared with the design parameters. An experimental assessment of the mechanical, thermal and acoustical parameters of the elemental modular facade was carried out in a laboratory. At the end of the article, the results and conclusions of the laboratory experiment are summarized.
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Sharma, Ravindra Nath, Vanessa Matthew-Belmar, Roxane Nicholas-Thomas, Gitanjali Arya, Bob Holtslander, Harry Hariharan, and Victor A. Amadi. "Prevalence of Salmonella spp. in red-footed tortoises (Chelonoidis carbonaria) from Grenada, West Indies." January-June 6, no. 1 (2020): 12–16. http://dx.doi.org/10.14202/ijoh.2020.12-16.
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Background and Aim: There is currently no published information on the prevalence of Salmonella spp. in pet red-footed tortoises in Grenada. Monitoring is essential to understand the dynamics of the epidemiology of Salmonella. This study aimed to estimate the prevalence of Salmonella spp. from pet red-footed tortoises from Grenada and to test for antimicrobial drug resistance of the isolates. Materials and Methods: Established bacterial culture, serotyping, and antimicrobial susceptibility methods were used. Fecal samples were obtained from 114 tortoises from five parishes of Grenada, and cultured for Salmonella using enrichment and selective culture techniques. The serotyping of isolated Salmonella was performed at the Office International des Epizooties Salmonella Reference Laboratory, Guelph, Ontario, Canada. The isolates were tested for antimicrobial susceptibility in the Microbiology Laboratory of the School of Veterinary Medicine, St. George's University, Grenada. Results: Fifteen tortoises (13.2%) out of 114 were positive for Salmonella spp. Five serovars were identified: Salmonella Javiana (6.3%), Salmonella Rubislaw (6.3%), Salmonella Saintpaul (18.75%), Salmonella Glostrup (6.3%), and S. I: Rough.O;e,h:1,2 (62.5%). All isolates were sensitive to the 12 antimicrobial drugs. Conclusion: Three serovars (S. Javiana, S. Saintpaul, and S. Rubislaw) are known pathogens causing disease in humans. Since tortoises included in the study were pets, the tortoises may be a possible source of transmission of Salmonella to their owners. The tortoise owners should be educated on the importance of hygienic raising of their pets. This is the first report of isolation of Salmonella spp. from pet red-footed tortoises in Grenada.
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Maļcevs, Aleksandrs, Jānis Jušinskis, Sergejs Truškovs, Viktors Ševeļevs, and Rafails Rozentāls. "Urine Neutrophil Gelatinase-Associated Lipocalin Determination as a Donor Auxiliary Examination Method — First Results." Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences 67, no. 1 (April 1, 2013): 14–18. http://dx.doi.org/10.2478/prolas-2013-0003.
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A growing lack of donor organs has caused extension of criteria for deceased donation. Therefore, elderly donors and donors with increased serum creatinine levels, as well as donors after cardiocirculatory death, have become used more frequently. The examination of such donors is strongly limited due to the lack of time, and the determination of the quality of donor organs is still based on clinical and laboratory screening data of donors. Implementation of new examination methods is required to determine the functional condition of donor organs more accurately, which would allow correct selection of donors. This retrospective study included all consecutive deceased donor (DD) kidney transplantations (KTx) performed in a single centre during the period from 1 January 2010 till 30 November 2011. The donor examination was supplemented by the urine neutrophil gelatinase-associated lipocalin (U-NGAL) test. Recipients were available for follow- up for at least 12 months (totally 97 KTx from 63 DD). All cases were divided into four groups according to U-NGAL and serum creatinine (S-Crea) levels in donors: group I - normal U-NGAL and S-Crea (n = 70); group II - elevated U-NGAL and S-Crea (n = 10); group III - elevated U-NGAL and normal S-Crea (n = 9); group IV - normal U-NGAL and elevated S-Crea (n = 8). Information about rates of delayed graft function (DGF) and immediate graft function (IGF), acute rejection (AR), recipient S-Crea levels during the first post-transplant year for functioning grafts, graft losses and recipient deaths were summarised. Donor urine NGAL level showed moderate correlation with donor S-creatinie level (r = 0.543, P < 0.001). DGF was observed in 20 recipients (21%) and demonstrated association with increased donor S-creatinine (0.135 ± 0.061 vs. 0.108 ± 0.04 mmol/l in IGF, p < 0.05). Combination of increased donor S-Crea and U-NGAL (group II) was associated with worse graft function during the first year after transplantation. Recipients in group III had increased S-Crea at the time of discharge from hospital and at one year after transplantation. One-year death censored graft survival and recipient survival was similar in all groups (P = NS). Determination of U-NGAL can be used as a donor auxiliary examination method for determination of the kidney graft functional condition and for prediction of post-transplant results. The study needs to be continued with a higher number of observations and longer post-transplant follow-up.
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Мамедов, Ризван, Rizvan Mamedov, Нигяр Садыгова, Nigar Sadigova, Лала Ибрагимова, and Lala Ibrahimova. "OPTIMIZATION OF METHODS FOR THE PREVENTION AND TREATMENT OF INFLAMMATORY PERIODONTAL DISEASES." Actual problems in dentistry 15, no. 2 (August 9, 2019): 114–21. http://dx.doi.org/10.18481/2077-7566-2019-15-2-114-121.
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Relevance. Medicines, taking into account the role of various microbial associations in the development of severe generalized forms of gingivitis and periodontitis, should have high antimicrobial activity, but their use can also cause growth inhibition and representatives of normal microflora. The purpose ― to evaluate the effectiveness of complex treatment of inflammatory periodontal diseases using new prophylactic agents. Material and research methods. For a comparative clinical and laboratory evaluation of the effectiveness of the therapeutic and prophylactic agents used, the patients were divided into 3 groups. With HGPLS - the control group - 18, in which treatment was limited only to hygienic education and the conduct of professional hygiene. The comparison group (20 people with CHPH) received treatment according to the generally accepted standard regimen and prescribed Curasept ADS 712 gel toothpaste. The main group (20 people with CHPH) received the standard therapy with Curaprox Enzycal toothpaste 1450ppm. Microbiological studies of a mixed oral fluid and clinical indices were performed in the work — the SBI bleeding index of the gingival sulcus (Muhlemann, 1971), Silness-Loe hygienic index (S-L, 1964). Evaluation of the cleansing, anti-inflammatory and hemostatic effects of the proposed medications was carried out before treatment and 1,3.6 months after treatment. Research results. The control group, the frequency of occurrence of A.actinomycetemcimitans and P.intermedia three months after the completion of treatment and preventive measures was 5.6 ± 5.4 and 11.1 ± 7.4 %, in the comparison group, where Curasept ADS toothpaste was administered 712, the indicators for the above bacteria dropped to zero. The detected values of the hygienic index three months after treatment in the main, control groups and in the comparison group, respectively, amounted to 1.12 ± 0.038; 1.30 ± 0.028 and 1.13 ± 0.041. In the long-term clinical observations in the main group, the values of the Conclusion. According to the data obtained, the use of Curaprox Enzycal paste with 3 enzymes and sodium fluoride in the minimum amount for use revealed its high prophylactic efficacy.
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Zhang, Haoran, Lluis Sanmiquel Pera, Vintro Sanchez Carla, and Yaojiang Zhao. "Applied Research of U-Shape Ventilation Network in Underground Mine/Badania Stosowane Sicie Wentylacyjnej W Kształcie „U” W Kopalni Podziemnej." Archives of Mining Sciences 59, no. 2 (June 1, 2014): 381–94. http://dx.doi.org/10.2478/amsc-2014-0027.
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Abstract For the purpose of fully and systematically observe, research and optimize the U-sharp ventilation system in Vilafruns mine, a simulation model based on the principles of geometric, kinematic and dynamic similarity is established in the simulation laboratory. By simulating a U-shape ventilation network, t he air volume distribution and wind velocity in different sections of the model were measured and compared with practical data obtained in Vilafruns mine. Results show that the lowest wind velocity in the model is higher than 0.42 m/s, thus it is in a turbulent f low state, which satisfies the kinematical and dynamic similarity principles. T he characteristic of air volume distribution and wind velocity in Vilafruns mine are basically simulated by the experimental model through the obtained data and figures, which reflects the establishment of the model is correct and successful, and the experimental data is accurate and reliable. Moreover, this model provides useful references for the selection of mine ventilation types and for the optimization of the existing ventilation network.
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Iampietro, R., A. M. Woolley, F. E. Preston, and S. Kitchen. "Anti Xa Monitoring during Treatment with Low Molecular Weight Heparin or Danaparoid: Inter-assay Variability." Thrombosis and Haemostasis 82, no. 10 (1999): 1289–93. http://dx.doi.org/10.1055/s-0037-1614377.
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SummaryIf laboratory monitoring of low molecular weight heparin (LMWH) therapy is required the test of choice is the anti Xa activity assay. The relationship between anti Xa results obtained using different techniques is unknown. The aim of the present study was to compare anti Xa results obtained with eight different commercially available anti Xa activity assays (five chromogenic and three clotting based assays) in samples from patients receiving either therapeutic or prophylactic LMWH (enoxaparin or dalteparin) or danaparoid.We have demonstrated that highly significant differences exist between results obtained using different techniques. The mean anti Xa activity in patients receiving treatment or prophylaxis with enoxaparin ranged from 0.28 to 0.64 iu/ml. A similar relationship was present in samples from patients treated with dalteparin, mean anti Xa results ranging from 0.43 to 0.69 iu/ml. The Heptest clotting assay as used here in combination with the Automated Coagulation Laboratory instrument, was associated with lower results than other clotting or chromogenic techniques. In patients receiving danaparoid for heparin induced thrombocytopaenia (HIT) mean results with three clotting based assays were 0.30 to 0.36 u/ml, compared to mean results of 0.47 to 0.65 u/ml for chromogenic assays.Our data clearly indicate that the selection of anti Xa assay method could influence patient management since the dose required to achieve the therapeutic range would differ according to the assay employed. This is particularly important since the frequency of hamorrhagic side effects has been shown by others to be dose dependant, irrespective of the concomitant anti Xa activity results. In danaparoid therapy the clotting assays studied here should not be employed for monitoring without a modified target range, unless it can be demonstrated that the higher doses required to achieve the therapeutic range are safe.
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Negm, Ahmed, Claus Petersen, Andrea Markowski, Birgit Luettig, Kristina Ringe, Tim Lankisch, Michael Manns, Benno Ure, and Andrea Schneider. "The Role of Endoscopic Retrograde Cholangiopancreatography in the Diagnosis of Biliary Atresia: 14 Years' Experience." European Journal of Pediatric Surgery 28, no. 03 (April 12, 2017): 261–67. http://dx.doi.org/10.1055/s-0037-1602260.
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Introduction Biliary atresia (BA) is a rare destructive inflammatory obliterative cholangiopathy of neonates. Early diagnosis is important in disease management. The aim was to evaluate the role of endoscopic retrograde cholangiopancreatography (ERCP) in diagnosing BA in a large cohort. In addition, we evaluated whether parameters such as bile trace, GGT, bilirubin, and laboratory values in combination can be used to develop a risk score that could indicate the referral to specialized centers. Materials and Methods All infants with neonatal cholestasis (2000–2014) who presented to our endoscopy unit for suspected BA were included. Demographics, laboratory parameters, ultrasound findings, liver biopsy results, ERCP diagnosis, and surgical outcome were collected. Value and safety of ERCP and risk factors for BA were retrospectively analyzed. Results We included 251 infants in our cohort (55% males, median age: 53 days). BA was intraoperatively diagnosed in 155 (83.4%) patients and was excluded in 30 (16.2%). Fifty-six cases were not operated due to the ERCP findings. ERCP was successful in 224/251 patients (89.2%) with no procedure-related complications. The operative and endoscopic diagnosis matched in 96.6% of the patients (positive predictive value: 92.2%, negative predictive value: 97.1%). In comparison to cases with excluded BA, the ones with this disease were significantly associated with absence of duodenal bile traces (98.4 vs. 1.6%, p < 0.001), higher bilirubin (p < 0.001, cutoff 7.3 mg/dL), and higher GGT (p < 0.001, cutoff 250 U/L). Conclusion ERCP is safe and accurate in the hands of experts in diagnosing BA if the cause of cholestasis is unclear. While evaluating the role of ERCP for diagnosing this disease, we found that the secondary parameters GGT > 250 U/L, bilirubin > 7.3 mg/dL (125 μmol/L), and the absence of bile traces are risk factors.
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GOLDING, G. R., P. N. LEVETT, R. R. McDONALD, J. IRVINE, M. NSUNGU, S. WOODS, A. HORBAL, et al. "A comparison of risk factors associated with community-associated methicillin-resistant and -susceptible Staphylococcus aureus infections in remote communities." Epidemiology and Infection 138, no. 5 (January 22, 2010): 730–37. http://dx.doi.org/10.1017/s0950268809991488.
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SUMMARYIn this case-control study, cases [community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA), n=79] and controls [community-associated methicillin-susceptible S. aureus (CA-MSSA), n=36] were defined as a laboratory-confirmed infection in a patient with no previous hospital-associated factors. Skin and soft tissue were the predominant sites of infection, both for cases (67·1%) and controls (55·6%). Most of the cases (79·7%) and controls (77·8%) were aged <30 years. Investigations did not reveal any significant statistical differences in acquiring a CA-MRSA or CA-MSSA infection. The most common shared risk factors included overcrowding, previous antibiotic usage, existing skin conditions, household exposure to someone with a skin condition, scratches/insect bites, and exposure to healthcare workers. Similar risk factors, identified for both CA-MRSA and CA-MSSA infections, suggest standard hygienic measures and proper treatment guidelines would be beneficial in controlling both CA-MRSA and CA-MSSA in remote communities.
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Lateef, A., T. E. Davies, A. Adelekan, I. A. Adelere, A. A. Adedeji, and A. H. Fadahunsi. "Akara Ogbomoso: Microbiological Examination and Identification of Hazards and Critical Control Points." Food Science and Technology International 16, no. 5 (September 21, 2010): 389–400. http://dx.doi.org/10.1177/1082013210366894.
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Akara Ogbomoso was examined toward the establishment of hazard analysis and critical control point (HACCP). The akara was produced in residential buildings with the attendant consequence of contamination. There was ample growth of aerobes, coliforms, staphylococci, Shigella and yeast/mold from the samples, water and cowpea pastes. Microbial contaminations occur through the processing, which can be corrected through education by adopting good hygienic and manufacturing practices. The critical control points were identified as frying, storage and refrying. It may be heated in the microwave for 10 s before consumption. Akara, prepared in the laboratory through the implementation of HACCP was not contaminated. Several bacterial isolates, namely; Escherichia coli, Staphylococcus aureus, Staphylococcus epidermidis, Citrobacter freundii, Serratia marcescens, Proteus vulgaris, Bacillus cereus, Streptococcus pyogenes, Bacillus sp. and Shigella sp., showed multiple resistance to antibiotics ranging from two to nine. Seven strains were not resistant to the antibiotics, while five were resistant to one type of antibiotic.
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Connors, Krista L., and Keith J. Karnok. "A Survey of beginning crop science courses at 49 U. S. Universities. II. Laboratory format, teaching methods, and topical content." Journal of Agronomic Education 15, no. 1 (March 1986): 60–62. http://dx.doi.org/10.2134/jae1986.0060.
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Rotter, M. L., W. Koller, G. Wewalka, H. P. Werner, G. A. J. Ayliffe, and J. R. Babb. "Evaluation of procedures for hygienic hand-disinfection: controlled parallel experiments on the Vienna test model." Journal of Hygiene 96, no. 1 (February 1986): 27–37. http://dx.doi.org/10.1017/s0022172400062501.
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SUMMARYControlled parallel experiments were performed on the Vienna test model for the evaluation of procedures for hygienic hand-disinfection in three laboratories (Vienna, Mainz, Birmingham). The degerming activity of four procedures, each taking 1 min, was assessed repeatedly and compared with that of a standard disinfection procedure (ST) using isopropanol 60 % (v/v). The mean log reductions (mean log RF) for each procedure were as follows: n−propanol 50% (v/v) 4·85 and 5·14 in Vienna (V) and Mainz (M) respectively, ethanol 70 % (v/v) + chlorhexidinegluconate 0·5% (w/v), 4·01 (V), 3·76 (M) and 4·00 in Birmingham (B). Washing procedures were less effective, mean log RF 's of 3·19 (V), 3·49 (M) and 3·04 (B) were obtained with povidone-iodine soap, and 2·91 (V), 3·37 (M) and 3·27 (B) with a liquid phenolic soap. Analysis of variance on the data from Vienna and Mainz revealed significant differences of means not only between procedures (‘preparations’) but also on repeat testing. To compensate for the influence of variables such as test subjects, laboratory and day, the Vienna test model provides a method of standardization by testing a ST in parallel with the test procedure (P).Standardization of the results was obtained by pair-wise substraction, log . Analysis of variance on the resulting values demonstrated that comparability of the results between laboratories and on repeat testing was achieved. The relative variation of the measurements within the laboratories ranged from 0·9 to 4·2%. As assessed by power-analysis, a disinfection procedure will be detected as significantly (P= 0·1) inferior to the standard processes in 95 of 100 experiments if it produces a mean log RF that is at least 0·55–0·65 log units smaller than that of the standard.
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Očenášová, Petra, Miloš Barták, and Josef Hájek. "Photoinhibition of photosynthesis in Antarctic lichen Usnea antarctica. II. Analysis of non-photochemical quenching mechanisms activated by low to medium light doses." Czech Polar Reports 4, no. 1 (January 1, 2014): 90–99. http://dx.doi.org/10.5817/cpr2014-1-10.
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The paper focus sensitivity of an Antarctic lichen Usnea antarctica to photoinhibition studied under controlled laboratory conditions. Main emphasis was given to the analysis of quenching mechanisms, i.e. deexcitation pathways of absorbed light energy exploited in non-photochemical processes. Thalli of U. antarctica were collected at the James Ross Island, Antarctica (57°52´57´´ W, 63°48´02´´ S) and transferred in dry state to the Czech Republic. After rewetting in a laboratory, they were exposed to medium light intensities (300, 600 and 1000 mmol m-2 s-1 of photosynthetically active radiation) for 6 h. Before and during photoinhibitory treatments, chlorophyll fluorescence parameters, photoinhibitory (qI), state 1-2 transition (qT), and energy-dependent quenching (qE) in particular were measured to evaluate dose- and time-dependent changes in these parameters. The results showed that among the components forming non-photochemical quenching (qN), qI contributes to the largest extent to qN, while qE and qT contribute less. This finding differs from our earlier studies made in a short term-, and high light-treated U. antarctica that found qE together with qI is the most important part of non-photochemical quenching. Possible explanation is that photoinhibition in PS II in U. ant-arctica, when induced by low to medium light, activates qE to only limited extend and for a relatively short time (tens of minutes). With prolonged high light treatment lasting several hours, qE tends to be reduced to the values close to zero and qI then forms a major part of qN.
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Nikolac Gabaj, Nora, Marijana Miler, Adriana Unic, Lara Milevoj Kopcinovic, Alen Vrtaric, and Jelena Culej. "Ascorbic acid in urine still compromises urinalysis results." Annals of Clinical Biochemistry: International Journal of Laboratory Medicine 57, no. 1 (October 23, 2019): 64–68. http://dx.doi.org/10.1177/0004563219882051.
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Background The aim of this work was to determine the frequency of ascorbic acid-positive urine samples and to evaluate the potential risk on patient safety. Materials and methods A total of 27,856 samples submitted for urinalysis in previous year were retrospectively analysed from the laboratory information system. Urinalysis was done on Iris IQ200 analyzer using 11-parameter iChem Velocity test strips. Risk analysis combined the impact of potentially erroneous results (due to ascorbic acid interference) on patient safety (severity – S) with their frequency (occurrence – O). Potential risk was identified as high, intermediate and low. Results One thousand one hundred and ninety-nine (4.3%) and 1646 (5.9%) samples were mildly (20 mg/dL, 1+) and highly positive (40 mg/dL, 2+) for ascorbic acid, respectively. Severity (S1 to S5) was assigned to four possible errors: false-negative glucose (U-Glc: S2), blood (U-Hb: S5), nitrite (U-Nit: S4) and bilirubin (U-Bil: S1). Based on the frequency of errors, occurrence was categorized as: O2 for U-Glc, and O3 for U-Bil, U-Nit and U-Hb. The risk analysis matrix revealed that false-negative U-Hb was associated with potentially high risk, false-negative U-Nit with intermediate risk, while false-negative U-Glc and U-Bil were associated with low risk on patient safety. Conclusions Positive ascorbic acid can cause potentially high risk for patient safety by missing positive blood in urine.
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Parkhurst, Drew B., Michael T. Andary, and John W. Powell. "An Additional Electrodiagnostic Tool for Ulnar Neuropathy: Mixed across the Elbow." Journal of Brachial Plexus and Peripheral Nerve Injury 15, no. 01 (January 2020): e16-e21. http://dx.doi.org/10.1055/s-0040-1714742.
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Abstract Background Diagnosing ulnar neuropathy at the elbow (UNE) remains challenging despite guidelines from national organizations. Motor testing of hand intrinsic muscles remains a common diagnostic method fraught with challenges. Objective The aim of the study is to demonstrate utility of an uncommon nerve conduction study (NCS), mixed across the elbow, when diagnosing UNE. Methods Retrospective analysis of 135 patients, referred to an outpatient University-based electrodiagnostic laboratory with suspected UNE between January 2013 and June 2019 who had motor to abductor digiti minimi (ADM), motor to first dorsal interosseus (FDI), and mixed across the elbow NCS completed. To perform the mixed across the elbow NCS, the active bar electrode was placed 10-cm proximal to the medial epicondyle between the biceps and triceps muscle bellies. The median nerve was stimulated at the wrist followed by stimulation of the ulnar nerve at the ulnar styloid. The difference between peak latencies, labeled the ulnar-median mixed latency difference (U-MLD), was used to evaluate for correlation between the nerve conduction velocities (NCV) of ADM and FDI. Results Pearson r-values = −0.479 and −0.543 (p < 0.00001) when comparing U-MLD to ADM and FDI NCV across the elbow, respectively. The negative r-value describes the inverse relationship between ulnar velocity across the elbow and increasing U-MLD. Conclusion Mixed across the elbow has moderate–strong correlation with ADM and FDI NCV across the elbow. All three tests measure ulnar nerve function slightly differently. Without further prospective data, the most accurate test remains unclear. The authors propose some combination of the three tests may be most beneficial when diagnosing UNE.
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Statsenko, Yauhen, Fatmah Al Zahmi, Tetiana Habuza, Klaus Neidl-Van Gorkom, and Nazar Zaki. "Prediction of COVID-19 severity using laboratory findings on admission: informative values, thresholds, ML model performance." BMJ Open 11, no. 2 (February 2021): e044500. http://dx.doi.org/10.1136/bmjopen-2020-044500.
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BackgroundDespite the necessity, there is no reliable biomarker to predict disease severity and prognosis of patients with COVID-19. The currently published prediction models are not fully applicable to clinical use.ObjectivesTo identify predictive biomarkers of COVID-19 severity and to justify their threshold values for the stratification of the risk of deterioration that would require transferring to the intensive care unit (ICU).MethodsThe study cohort (560 subjects) included all consecutive patients admitted to Dubai Mediclinic Parkview Hospital from February to May 2020 with COVID-19 confirmed by the PCR. The challenge of finding the cut-off thresholds was the unbalanced dataset (eg, the disproportion in the number of 72 patients admitted to ICU vs 488 non-severe cases). Therefore, we customised supervised machine learning (ML) algorithm in terms of threshold value used to predict worsening.ResultsWith the default thresholds returned by the ML estimator, the performance of the models was low. It was improved by setting the cut-off level to the 25th percentile for lymphocyte count and the 75th percentile for other features. The study justified the following threshold values of the laboratory tests done on admission: lymphocyte count <2.59×109/L, and the upper levels for total bilirubin 11.9 μmol/L, alanine aminotransferase 43 U/L, aspartate aminotransferase 32 U/L, D-dimer 0.7 mg/L, activated partial thromboplastin time (aPTT) 39.9 s, creatine kinase 247 U/L, C reactive protein (CRP) 14.3 mg/L, lactate dehydrogenase 246 U/L, troponin 0.037 ng/mL, ferritin 498 ng/mL and fibrinogen 446 mg/dL.ConclusionThe performance of the neural network trained with top valuable tests (aPTT, CRP and fibrinogen) is admissible (area under the curve (AUC) 0.86; 95% CI 0.486 to 0.884; p<0.001) and comparable with the model trained with all the tests (AUC 0.90; 95% CI 0.812 to 0.902; p<0.001). Free online tool at https://med-predict.com illustrates the study results.
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Rand, Jacob, Paolo Bucciarelli, Ulrich Budde, Perry van Genderen, Hiroshi Mohri, Dominique Meyer, Francesco Rodeghiero, Evan Sadler, and Augusto Federici. "Acquired von Willebrand Syndrome: Data from an International Registry." Thrombosis and Haemostasis 84, no. 08 (2000): 345–49. http://dx.doi.org/10.1055/s-0037-1614018.
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SummaryThe acquired von Willebrand syndrome (AvWS) is a rare bleeding disorder with laboratory findings similar to those of congenital von Willebrand disease (vWD). Despite the numerous cases reported in the literature until 1999 (n = 266), large studies on AvWS are not available. Moreover, diagnosis of AvWS has been difficult and treatment empirical. These considerations prompted us to organize an international registry. A questionnaire, devised to collect specific information on AvWS, was sent to all the members of the International Society on Thrombosis and Haemostasis (ISTH), who were invited to respond if they had diagnosed cases with the AvWS cases. 156 members answered the questionnaire and 54 of them sent information on 211 AvWS cases from 50 centers. Data were compared with those already published in the literature and 25 cases already described or not correctly diagnosed were excluded. The 186 AvWS cases that qualified for the registry were associated with lymphoproliferative (48%) and myeloproliferative disorders (15%), neoplasia (5%), immunological (2%), cardiovascular (21%) and miscellaneous disorders (9%). Ristocetin cofactor activity (vWF:RCo) or collagen binding activity (vWF:CBA) were usually low in AvWS (median values 20 U/dL, range 3-150), while factor VIII coagulant activity was sometimes normal (median 25 U/dL, range 3-191). FVIII/vWF inhibiting activities were present in only a minority of cases (16%). Bleeding episodes in AvWS were mostly of mucocutaneous type (68%) and were managed by DDAVP (32%), FVIII/vWF concentrates (37%), intravenous immunoglobulins (33%), plasmapheresis (19%), corticosteroids (19%) and immunosuppressive or chemotherapic agents (35%). Based upon the data of this international registry, it appears that AvWS is especially frequent in lympho-or myeloproliferative and cardiovascular diseases. Therefore, AvWS should be suspected and searched with the appropriate laboratory tests especially when excessive bleeding occurs in patients with these disorders. On the basis of the information provided by this registry guidelines for diagnosis and management of the AvWS are given.
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Khan, Ambereen, April Bailey, Takeshi Yokoo, Ivan Pedrosa, Donald McIntire, F. Cunningham, and David Nelson. "Liver Injury in Hemolysis, Elevated Liver Enzymes, and Low Platelets Syndrome Measured by Diffusion-Weighted Magnetic Resonance Imaging." American Journal of Perinatology 35, no. 08 (December 27, 2017): 741–47. http://dx.doi.org/10.1055/s-0037-1613684.
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Objective The objective of this study was to evaluate acute liver injury (ALI) detected by diffusion-weighted magnetic resonance imaging (MRI) and the associated laboratory findings in women with hemolysis, elevated liver enzymes, and low platelet (HELLP) syndrome. Study Design This was a retrospective, observational study of women with HELLP syndrome defined by serum aspartate aminotransferase (AST) levels ≥100 U/L and thrombocytopenia with platelets ≤100,000/µL. All women underwent MRI postpartum including diffusion-weighted imaging to estimate the volume of ALI with reconstructed apparent diffusion coefficient (ADC) maps. The ADC map and the volume of ALI were compared with laboratory abnormalities by Spearman's correlation analysis. Results From March 2013 through August 2015, 16 women with HELLP syndrome underwent MRI, and of these, 14 (88%) women had areas of increased signal intensity suggestive of ALI. Their median (range) maximum AST level was 262 (140–1,958) IU/L, and at the time of MRI, AST was 103 (36–1,426) IU/L. Both of these AST levels significantly correlated with ADC map as well as the volume of ALI (both p-values <0.001). Conclusion Women with HELLP syndrome frequently exhibited areas of abnormal diffusion in the liver on diffusion-weighted MRI, suggestive of ALI. The extent of liver injury was significantly correlated with serum AST.
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Tobisu, Mamoru, Naoto Chatani, and Victor Snieckus. "Cluster Preface: C–O And Related Bond Activation." Synlett 28, no. 19 (November 20, 2017): 2559–60. http://dx.doi.org/10.1055/s-0036-1592031.
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Mamoru Tobisu received his PhD from Osaka University under the direction of Prof. Shinji Murai (2001). During his PhD studies, he was a visiting scientist (1999) with Prof. Gregory C. Fu at MIT. Following a period as a scientist at the Takeda Pharmaceutical Company (2001–2005), he started his academic career at Osaka University in 2005 as an assistant professor with Prof. Naoto Chatani. He was then appointed as an associate professor at the Center for Atomic and Molecular Technologies at Osaka University (2011) and was promoted to full professor at the Department of Applied Chemistry of Osaka University (2017). He received the Thieme Chemistry Journals Award (2008), the Chemical Society of Japan Award for Young Chemists (2009), the Young Scientists’ Award, a Commendation for Science and Technology from the Minister of Education, Culture, Sports, Science and Technology (2012), the Merck-Banyu Lectureship Award (2012), Thomson Reuters Research Front Award (2016), and the Mukaiyama Award (2018). Naoto Chatani received his PhD in 1984 under Professors Noboru Sonoda and Shinji Murai. In 1984, he joined the Institute of Scientific and Industrial Research at Osaka University as an Assistant Professor in the laboratory of Professor Terukiyo Hanafusa. After postdoctoral studies (1988–1989 under Professor Scott E. Denmark at the University of Illinois, Urbana-Champaign), he moved back to Osaka University and was promoted to the rank of Associate Professor (1992) and to Full Professor (2003). He is a recipient of The Chemical Society of Japan Award for Young Chemists (1990), The Green & Sustainable Chemistry Award from the Minister of Education, Culture, Sports, Science and Technology (2005), the Nagoya Silver Medal (2013), The Chemical Society of Japan Award (2017), a Humboldt Research Award (2017), a Clarivate Analytics Highly Cited Researcher (2017) and will be a recipient of an Arthur C. Cope Scholar Award (2018). Victor Snieckus was born in Kaunas, Lithuania and spent his childhood in Germany during World War II. He received training at U. Alberta, Canada, (B.Sc.), U. California, Berkeley (M.Sc. D.S. Noyce), and U. Oregon (Ph.D. Virgil Boekelheide). He returned to his adopted country for postdoctoral studies (National Research Council, Ottawa, Ted Edwards). Appointments: U. of Waterloo, Assistant (1966) to Professor (1979); Monsanto/NRC Industrial Research Chair, 1992–1998; Queen’s University, Inaugural Bader Chair in Organic Chemistry (1998–2009); Bader Chair Emeritus and Director, Snieckus Innovations, 2009-. Selective awards: A.C. Cope Scholar (2001, one of 5 Canadians), Order of the Grand Duke Gediminas (2002, from the President of Lithuania), Arvedson-Schlenk (2003, Gesellschaft Deutscher Chemiker), Bernard Belleau (2005, Canadian Society for Chemistry), Givaudan-Karrer Medal (2008, U. Zurich), Honoris causa (2009, Technical U. Tallinn, Estonia), Global Lithuanian Award (2012), Yoshida Lectureship (2017). He hopes that he has only temporarily discontinued playing hockey and wishes also to return to the clarinet.