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Journal articles on the topic 'Hyperglycemia-Induced Hyponatremia'

Author: Grafiati

Published: 7 June 2025

Last updated: 16 July 2025

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1

Jiang, Yu-cai, Cheng-fei Zhao, and Lin-lin Zheng. "Linperlisib causing high blood sugar and hyponatremia, leading to facial nerve paralysis and muscle nerve damage: A rare case report." Medicine 104, no. 24 (2025): e42875. https://doi.org/10.1097/md.0000000000042875.

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Rationale: Linperlisib is a highly selective small-molecule inhibitor of phosphatidylinositol-3-kinase delta for the treatment of relapsed/refractory follicular lymphoma. Patient concerns: The patient was a 64-year-old male with peripheral T-cell lymphoma and diabetes mellitus who experienced hyperglycemia, hyponatremia, facial palsy, and myalgia during linperlisib treatment. Diagnoses: Drug-induced high blood sugar and hyponatremia. Interventions: Active management of hyperglycemia during hospitalization and hyponatremia was corrected with active symptomatic treatment. Outcomes: During hospit

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Wolf, Matthew B. "Hyperglycemia-induced hyponatremia: Reevaluation of the Na + correction factor." Journal of Critical Care 42 (December 2017): 54–58. http://dx.doi.org/10.1016/j.jcrc.2017.06.025.

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3

Kashyap, A. S. "Hyperglycemia-Induced Hyponatremia: Is It Time to Correct the Correction Factor?" Archives of Internal Medicine 159, no. 22 (1999): 2745—a—2746. http://dx.doi.org/10.1001/archinte.159.22.2745-a.

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4

Wittbrodt, Eric T. "Maintaining Fluid and Electrolyte Balance During Exercise." Journal of Pharmacy Practice 16, no. 1 (2003): 45–50. http://dx.doi.org/10.1177/0897190002239633.

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The well-documented benefits and popularity of sports and fitness have led to an increased demand for products that not only replace sweat losses but also provide fuel for continued high-intensity metabolic demands. The twin risks of hypohydration and hyponatremia can lead to morbid and even fatal outcomes if rational replacement regimens are not followed, especially in endurance athletes and during hot or humid conditions. The avoidance of these complications of physical activity with oral replacement products has been documented primarily in high-impact, prolonged-duration events. Replacemen

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5

Adyanthaya, Sindhoora, Fnu Anila, and Bethany Jackson. "ODP225 Mixed Diabetic Ketoacidosis and Hyperglycemic Hyperosmolar Syndrome with recent diagnosis of Diabetes Mellitus." Journal of the Endocrine Society 6, Supplement_1 (2022): A326—A327. http://dx.doi.org/10.1210/jendso/bvac150.676.

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Abstract Background Diabetic ketoacidosis (DKA) and hyperosmolar hyperglycemia syndrome (HHS) are often discussed as two distinct clinical entities but can present in the same patient. Combined DKA and HHS is associated with higher mortality than either DKA or HHS alone. Clinical case: A 68 years old female diagnosed with type 2 diabetes 3 months prior to hospitalization was brought into the hospital with severe hyperglycemia and altered mental status. On exam she was unresponsive with grimace only to sternal rub. Pulse was elevated at 113, RR 31, temperature 100.3, and blood pressure 130/80.

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Sai, P. Shoba, Ch Kiranya, K. Savitha, A. Manasa, Amatul Ali Sameera, and Nazia Lateef Amrohi. "A Retrospective Study on Drug Induced Complications Among Different Age Groups." Journal of Neonatal Surgery 14, no. 8S (2025): 567–76. https://doi.org/10.52783/jns.v14.2581.

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Aim And Objective: This study is aimed to perform a retrospective study on drug induced complications among different age groups. Methodology: This retrospective study was conducted at Aware Global Hospital in Hyderabad aimed to investigate the prevalence of drug induced complications among them. Over a 6 months period, data was collected from 85 patient cases from general medicine department. Results: The research findings reveal a higher drug induced complications incidence in males (54%) than females (46%), predominantly drug induced hypoglycemia (27.05%). According to WHO classification of

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7

Bregadioli, G. C., M. M. Santos, F. M. Cerri, et al. "Effectiveness of oral electrolyte solutions with different compositions for the treatment of neonatal calves with induced osmotic diarrhea." Arquivo Brasileiro de Medicina Veterinária e Zootecnia 75, no. 1 (2023): 1–13. http://dx.doi.org/10.1590/1678-4162-12730.

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ABSTRACT In a randomized controlled trial, we evaluated the effects of five oral electrolyte solutions (OESs) with different compositions of water, electrolyte, and acid-base balances of diarrheal neonatal calves. Osmotic diarrhea and dehydration were induced with sucrose in milk, spironolactone, and hydrochlorothiazide for 48 h in thirty 10-day old Holstein healthy calves with 43.5 ± 3.80 kg BW who were fed with natural milk. They were allocated to five treatment groups (n=6) based on the administered OES (commercial: OES A, B, C, D; and non-commercial: OES UEL). On the day of treatment, the

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8

Bedford, J. J., and J. P. Leader. "Response of tissues of the rat to anisosmolality in vivo." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 264, no. 6 (1993): R1164—R1179. http://dx.doi.org/10.1152/ajpregu.1993.264.6.r1164.

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Rats were exposed to osmotic stress either acutely, over periods of 1 or 4 h, or chronically, over several days. In acute experiments, hyposmolality was induced by intraperitoneal infusion of dilute glucose or mannitol solutions, whereas hyperosmolality was induced by use of sodium chloride, concentrated glucose or mannitol solutions, or urea. Chronic hypernatremia was induced by daily administration of sodium chloride to water-deprived animals; chronic hyponatremia was induced by daily injection of antidiuretic hormone supplemented with glucose. Animals were made hyperglycemic using streptozo

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9

Weiner, R. S., B. S. Kramer, G. H. Clamon, et al. "Effects of intravenous hyperalimentation during treatment in patients with small-cell lung cancer." Journal of Clinical Oncology 3, no. 7 (1985): 949–57. http://dx.doi.org/10.1200/jco.1985.3.7.949.

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One hundred nineteen patients were entered onto a randomized trial of the role of intravenous hyperalimentation (IVH) in patients with small-cell lung cancer. IVH was given during the first 30 days of induction chemotherapy to 54 patients. IVH did not effect any improvement in response or survival from therapy. In view of the lack of benefits from IVH, an analysis was made of the toxicities suffered by the 54 patients receiving IVH as well as any effects IVH might have made on chemotherapy-induced toxicity. Toxicities observed included mechanical difficulties with the catheter leading to tempo

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10

Khoo, Jun Kit, Meng Loong Mok, Pavai Sthaneswar, et al. "LIPOPROTEIN X-MEDIATED PSEUDOHYPONATREMIA IN A PATIENT WITH TYPE 2 DIABETES." Journal of the ASEAN Federation of Endocrine Societies 40, S1 (2025): 66. https://doi.org/10.15605/jafes.040.s1.111.

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INTRODUCTION/BACKGROUNDPseudohyponatremia is a lab abnormality commonly caused by hypertriglyceridemia, hyperglycemia or hypergammaglobulinemia. Lipoprotein X (LpX) is an abnormal lipoprotein that most commonly appears in the plasma of patients with cholestasis. LpX-mediated pseudohyponatremia is rare but has been described in the literature. We report a patient with type 2 diabetes mellitus (T2DM) and LpX-mediated pseudohyponatremia due to severe cholestatic hepatitis. CASEA 31-year-old female was admitted with newly diagnosed T2DM and severe DKA secondary to bilateral calf abscesses. She was

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11

Seery, Tara Elisabeth, Mira Kistler, Chaitali Singh Nangia, et al. "Immunotherapy combining NK and T cell activation with IL-15 super agonist (N-803), off-the-shelf high-affinity CD16 NK (haNK) or PDL1 targeted haNK and checkpoint inhibitor in relapsed/refractory advanced pancreatic cancer." Journal of Clinical Oncology 38, no. 15_suppl (2020): e15015-e15015. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.e15015.

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e15015 Background: Pancreatic cancer is the third leading cause of cancer-related deaths in the US. Patients who relapse after first/second-line chemotherapy have a 2 month median survival. In this relapsed population, there is no approved therapy. Effective response requires a coordinated approach that orchestrates both the innate and adaptive immune system. We hypothesize that by orchestrating the activation of the entire immune system, we could accomplish immunogenic cell death with clinical benefit. We describe a first-in-human novel combination immunotherapy protocol of chemoradiation, cy

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12

Takamatsu, Yasushi, Yutaka Imamura, Tomonori Nakazato, et al. "Once-Weekly Subcutaneous Bortezomib Plus Oral Cyclophosphamide and Dexamethasone Therapy For Relapsed Or Refractory Multiple Myeloma." Blood 122, no. 21 (2013): 5382. http://dx.doi.org/10.1182/blood.v122.21.5382.5382.

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Abstract Background We previously reported that twice-weekly intravenous bortezomib plus doxorubicin and intermediate-dose dexamethasone (iPAD) therapy induced a high complete response (CR) rate of 30% and prolonged remission duration of median 12.1 months in patients with relapsed or refractory myeloma. However, sensory neuropathy was observed in 78% of the patients with grade 3 neuropathy in 22%. To reduce the toxicity, we conducted once-weekly subcutaneous bortezomib therapy given in combination with oral cyclophosphamide and dexamethasone (sVCD). Methods This was a phase 2 multicenter stud

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13

Mandava, Sri, Lucas Pfeifer, Gretel D’Souza, and Mark Wilson. "Diabetes Induced Osmotic Demyelination of the Pons in a Patient on Peritoneal Dialysis." Journal of the Endocrine Society 5, Supplement_1 (2021): A375. http://dx.doi.org/10.1210/jendso/bvab048.764.

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Abstract Introduction: Osmotic demyelination of the pons as a result of uncontrolled diabetes is a rare event. Here we present a unique case of central pontine myelinolysis in a patient with poorly controlled type 2 diabetes mellitus in the setting of peritoneal dialysis. Clinical Case: A 48-year-old male with a history of insulin-dependent diabetes mellitus, hypertension, non-ischemic cardiomyopathy, and end-stage renal disease, treated with peritoneal dialysis, presented to the hospital for slurred speech, inability to walk, and persistent hyperglycemia for 3 days. Approximately 2 years prio

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14

Falchi, Lorenzo, Jennifer Kimberly Lue, Francesca Montanari, et al. "Combined Hypomethylating Agents (HMA) and Histone Deacetylase Inhibitors (HDACi) Exhibit Compelling Activity in Patients with Peripheral T-Cell Lymphoma (PTCL) with High Complete Response Rates in Angioimmunoblastic T-Cell Lymphoma (AITL)." Blood 132, Supplement 1 (2018): 1002. http://dx.doi.org/10.1182/blood-2018-99-116605.

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Abstract Introduction: PTCL may represent the prototypical epigenetic malignant disorder. First, recurring mutations in important epigenetic regulators, such as TET2, IDH2, and DNMT3, have been described across several PTCL subtypes, though especially in AITL. Second, HDACi have only been approved as single agents in patients with relapsed/refractory (R/R) PTCL, and exhibit T-cell lineage-specific activity across disease subtypes. Thirdly, preclinical evidence from our group suggests marked class synergism between HDACi and HMA. In addition, across a panel of diverse T-cell lymphoma lines, the

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15

Rosenbaum, Cara A., Brandelyn Pitcher, Nancy L. Bartlett, et al. "Phase II Trial of Ofatumumab (OFA) in Previously Untreated Follicular Non-Hodgkin Lymphoma (NHL): CALGB 50901 (Alliance)." Blood 126, no. 23 (2015): 2741. http://dx.doi.org/10.1182/blood.v126.23.2741.2741.

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Abstract Background: Rituximab has proven safety and efficacy in untreated patients with advanced stage follicular lymphoma (FL) with response rates upward of 67% (Ghielmini et al., Blood 2004). OFA is a fully humanized anti-CD20 mAb with higher CD20 antigen affinity and increased complement dependent cytotoxicity compared to rituximab. OFA has demonstrated activity in relapsed/refractory FL and high risk untreated FL in combination with chemotherapy. We therefore investigated OFA monotherapy as initial treatment for low/intermediate (int) risk, advanced stage FL in order to determine single a

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16

Ferdjallah, Mohammed, asaad asadi, Zeid Khitan, and Henry Driscoll. "Analysis of Electrolytes and Fluid Volumes Disturbances during Hyperglycemia-Induced Hyponatremia in Diabetes Mellitus Type 1." MedPress Public Health and Epidemiology 4, no. 1 (2024). https://doi.org/10.5281/zenodo.13892438.

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<strong>Abstract: </strong>The objective of this study is to investigate the effects of hypovolemia on hyperglycemiainduced hyponatremia in diabetes mellitus type 1 (DMT1). Because of the change in osmolarity due to increased serum glucose, the serum sodium concentration may be relative and may not reflect the actual concentration of sodium. Although it has been accepted that serum sodium must be corrected by a factor of 1.6 during hyperglycemia-induced hyponatremia, recent studies suggest that the correction factor is much higher when serum glucose is higher than

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17

Panneer, Serene Balaji, and Ayush Jain. "Neuroimaging in uncontrolled hyperglycemia: a case series and literature review." Egyptian Journal of Radiology and Nuclear Medicine 55, no. 1 (2024). http://dx.doi.org/10.1186/s43055-024-01195-1.

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Abstract Background There are wide-ranging differential diagnoses for the myriad of neurological symptoms associated with non-ketotic hyperglycemia. Similarly, various secondary complications of diabetic ketoacidosis present with nonspecific clinical symptoms. These are inadvertently misdiagnosed as epilepsies and strokes with associated hyperglycemia. Direct association between these nonspecific symptoms and hyperglycemia has been proved by demonstrating their resolution with correction of the latter. This case series portrays the spectrum of few rare neuroimaging findings of uncontrolled hyp

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18

Choudhari, Pooja, and Sudha Mootha. "THU147 Peritoneal Dialysis To Improve Hyperglycemic Hyperosmolar State In Child With Renal Failure." Journal of the Endocrine Society 7, Supplement_1 (2023). http://dx.doi.org/10.1210/jendso/bvad114.1399.

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Abstract Disclosure: P. Choudhari: None. S. Mootha: None. Background: Hyperglycemic hyperosmolar state (HHS) without ketosis is rare in children. While the crux of management of HHS is extensive hydration followed by insulin, this management can be difficult for children with kidney failure. Clinical Case: A 6-year-old female with complex medical history including Jeune syndrome (asphyxiating thoracic dystrophy), end stage renal disease status post kidney transplant, currently with rejection, now on peritoneal dialysis (PD), and history of steroid induced hyperglycemia was admitted for altered

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19

Velayutham S, Sakthi, Sowmini PR, Malcolm Jeyaraj K, Sathish Kumar M, and Arunan S. "OSMOTIC DEMYELINATION SYNDROME IN UNUSUAL SETTINGS." PARIPEX INDIAN JOURNAL OF RESEARCH, December 15, 2022, 36–39. http://dx.doi.org/10.36106/paripex/7306705.

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Objective: To highlight the occurrence of osmotic demyelination syndrome (ODS) in settings other than the classical ODS induced by rapid correction of hyponatremic states. The background, clinico- radiological features, treatment and outcome of eight ODS patients are discussed here. We encountered eight patients with ODS in Materials and Methods: uncommon clinical settings at the department of neurology, Government Stanley medical college hospital, Chennai between April 2017 to October 2018. Patients were evaluated, investigated, treated and outcome was assessed. Results: Eight patients in the

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20

Das, Aleena, Mrutyunjay Suar, and K. Sony Reddy. "Hormones in Malaria Infection: Influence on Disease Severity, Host Physiology, and Therapeutic Opportunities." Bioscience Reports, November 4, 2024. http://dx.doi.org/10.1042/bsr20240482.

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Human malaria, caused by Plasmodium parasites, is a fatal disease that disrupts the host’s physiological balance and affects the neuroendocrine system. This review explores how malaria influences and is influenced by hormones. Malaria activates the Hypothalamus-Pituitary-Adrenal axis, leading to increased cortisol, aldosterone, and epinephrine. Cortisol, while reducing inflammation, aids parasite survival, whereas epinephrine helps manage hypoglycemia. The Hypothalamus-Pituitary-Gonad and Hypothalamus-Pituitary-Thyroid axes are also impacted, resulting in lower sex and thyroid hormone levels.

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21

Abate, Ejigayehu G., and Amanda McKenna. "SUN-342 Effect of Hyperglycemia on Bone Mineral Density and Fracture in Pre-Liver Transplant Recipients." Journal of the Endocrine Society 4, Supplement_1 (2020). http://dx.doi.org/10.1210/jendso/bvaa046.1806.

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Abstract The liver plays an important role in bone and mineral metabolism of patients with end-stage liver disease. These patients are known to have an increased risk of osteoporosis and fractures before liver transplant (LT) with reported fracture incidence of 10-56%. The cause is multifactorial, which includes their underlying liver disease, chronic illness, vitamin D deficiency, and hyponatremia. The impact of hyperglycemia and diabetes mellitus on bone health in liver transplant recipients is not known. Hypothesis: Hyperglycemia increases risk of fracture and osteoporosis in pre- LT patien

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22

Porntharukchareon, Thachanun, Borwonkhun Tontivuthikul, Nattaya Sintawichai, and Panudda Srichomkwun. "Pembrolizumab- and ipilimumab-induced diabetic ketoacidosis and isolated adrenocorticotropic hormone deficiency: a case report." Journal of Medical Case Reports 14, no. 1 (2020). http://dx.doi.org/10.1186/s13256-020-02502-w.

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Abstract Background Several human monoclonal antibodies directed against immune checkpoints, including T lymphocyte antigen 4 and programmed cell death protein 1, have been implemented for cancer treatment in order to promote effector T cell response to tumors. Despite the antitumor activity of these agents, a significant number of patients demonstrated immune-related adverse events that affected the functions of multiple organs, including the endocrine system. We report the first case of immune checkpoint inhibitor–induced simultaneous diabetic ketoacidosis and isolated adrenocorticotropic ho

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23

Aljaberi, Asma Khaled, and Fatemeh Hazin. "SAT-682 Unusual Presentation of Diabetic Ketoacidosis Associated with Hypernatremia in Adult Patient." Journal of the Endocrine Society 4, Supplement_1 (2020). http://dx.doi.org/10.1210/jendso/bvaa046.1631.

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Abstract Diabetic ketoacidosis (DKA) is an acute, life threatening complication of diabetes characterized by hyperglycemia, ketonemia and acidosis. It is known to commonly present with hyponatremia and rarely with hypernatremia. DKA can present with hypernatremia in pediatric population which carries poor prognosis when present. We present a 27 year- old Ethiopian lady, previously healthy who was brought to emergency department (ED) with decreased level of consciousness. She had polyuria and polydipsia associated with weight loss for 1 month and flu like symptoms for 3 days prior to admission.

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