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Коленко, Фаіна Григорівна, Фаина Григорьевна Коленко та Faina Hryhorivna Kolenko. "Лицевые гиперкинезы: критерии диагностики". Thesis, Изд-во СумГУ, 2007. http://essuir.sumdu.edu.ua/handle/123456789/5636.
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MacDonald, Mary Ann. "Memory and metamemory in hyperactive children." Thesis, University of British Columbia, 1990. http://hdl.handle.net/2429/30999.
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Memory and metamemory were examined in 30 hyperactive and 30 nonhyperactive children matched on age, grade, and IQ (as measured by the Vocabulary and the Block Design subtests of the WISC-R), within the context of a broad range of tasks. The five tasks investigated in this study were: (a) a prospective memory task, (b) a feeling-of-knowing task, a visual retention task, (c) a word generation task, (d) and (e) an object span and recall task.
Previous research has demonstrated considerable variability in the performance of hyperactive children on memory tasks. They have been shown to perform as well as normal children on tasks of cued recall, paired associates for meaningful words, and on tests of recognition memory. They are distinguished from normal children by their poor performance on tasks of uncued recall, paired associates learning for semantically unrelated words, and in addition, often display performance decrements when task demands increase.
The results of this study suggest that hyperactive children are less efficient in metamemory knowledge and skills than normal children. These findings are consistent with the proposal that the difficulties hyperactive children demonstrate on memory tasks may result from a deficiency in their ability to efficiently engage in metamemory processes.
The hyperactive children in this study generally had more difficulty than the control children with recall on all the tasks. These included tests of both verbal and nonverbal memory, short and long-term memory, and prospective remembering. Further, they did not derive a memorial benefit, as the control subjects did, when generating their own recall items, or when recalling visual stimuli that could be more easily verbally encoded than others.
The hyperactive subjects demonstrated their recall abilities by performing as well as the normal subjects on the recall of read words in the word generation task, and on the recall of the low and medium level of labelability items in the visual retention task. Also, the recall performance of the hyperactive subjects differed significantly between a no-strategy and a provided strategy condition on the prospective memory task. Moreover, there were no group differences on the recognition memory test of the feeling-of-knowing task.
The results of this study are consistent with the previous investigations of memory performance in hyperactive children. The present findings further extend the past research by demonstrating selective memory deficits in the hyperactive subjects that are consistent with deficits in metamemory abilities. The proposition that metamemory skills are implicated in the difficulties that the hyperactive children demonstrated in this study is further supported by the difficulty they experienced in describing how they remembered the task items. The hyperactive subjects had more difficulty than the control subjects when attempting to describe a strategy that they used to aid recall. The strategies they described, relative to the control subjects, tended to be vague and poorly defined. These findings suggest that there may be both qualitative and quantitative differences in the way in which hyperactive and normal children use strategies.
In summary, the findings of this study suggest that hyperactive children, relative to normal children, seem to be deficient in both their metamemory knowledge and the ability to monitor and control their memory performance. Questions addressing whether these children cannot or do not employ these skills were introduced. The clinical implications of the findings were considered and recommendations were made for future research.<br>Arts, Faculty of<br>Psychology, Department of<br>Graduate
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Coghill, David Rockwell. "Heterogeneity in hyperkinetic disorder." Thesis, University of Dundee, 2010. https://discovery.dundee.ac.uk/en/studentTheses/afa9d9e9-eadb-49bf-8c83-db47eb0cadd9.
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It is increasingly recognised that the broadly defined behavioural phenotype of attention deficit – hyperactivity disorder (ADHD) is a heterogeneous condition and that this heterogeneity is seen across all levels of analysis from the genetic and environmental causes to the associated neuropsychological deficits, the clinical presentation and response to treatment. This work investigated whether the more restrictive and clinically homogeneous hyperkinetic disorder (HKD) phenotype is associated with reduced neuropsychological heterogeneity compared with the broader ADHD phenotype. Using a well known, broad based battery of neuropsychological tasks from the Cambridge Neuropsychological Test Automated Battery (CANTAB) and a computerised Go/NoGo task in a large well described group of boys with rigorously diagnosed HKD who were stimulant medication naïve at baseline, it was demonstrated that the neuropsychological heterogeneity in the HKD boys was very similar to that seen previously in children with ADHD. Interestingly, and contrary to popular opinion, the strongest associations were with more simple recognition memory tasks with a low executive demand. Although there were significant associations between HKD and deficits on a range of tasks with high executive demands these were less strong. Could this neuropsychological heterogeneity be a function of different developmental issues or comorbidity? With respect to development there was evidence that boys with HKD lagged behind the healthy boys with respect to the development of their neuropsychological performance. However the pattern of development was similar with the performance of the HKD boys paralleling that of the healthy boys, suggesting that the neuropsychological heterogeneity seen in HKD is not accounted for by developmental issues. With respect to the relationship between neuropsychological functioning and comorbidity, the impact of comorbid oppositional defiant disorder (ODD) and conductdisorder (CD), it was found that all three clinical groups (pure HKD, HKD + ODD and HKD + CD) demonstrated deficits on several tasks compared with the healthy boys. Compared with healthy boys each of the three clinical groups was associated with at least one unique neuropsychological deficit. This suggests that comorbidity between HKD and both ODD and CD may contribute to the neuropsychological heterogeneity in the HKD boys. Is there an association between clinical and neuropsychological responses to the treatment of HKD with the stimulant drug methylphenidate (MPH)? Detailed analyses were conducted to investigate heterogeneity of clinical and neuropsychological response in these boys to MPH. As predicted in previous studies there is evidence for clinical heterogeneity in response with between 68 and 78% of boys with HKD responding to MPH treatment at either one or both of the doses. The precise proportion responding was dependent on the scale and definition of response used. Clinical response was not predicted by age but was predicted to a degree by severity of symptoms at baseline and it was generally true that better response was predicted by lower (better) scores at baseline. Baseline performance on a component reflecting recognition memory performance at baseline predicted clinical response to the lower (0.3 mg/kg/dose), but not the higher (0.6, mg/kg/dose) dose of MPH with poorer baseline neuropsychological performance predicting a better clinical response. Whilst there was improvement on some neuropsychological measures following administration of MPH there was little association between clinical and neuropsychological responses to medication. Clinical response was only associated with neuropsychological response on a single measure from a single task (Go/NoGo Block 2 Errors to Distractors), a task that did not itself discriminate between the HKD boys and healthy Controls at baseline.
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Eekhof, Job Lambert Adam. "Electrophysiological investigations in cranial hyperkinetic syndromes." [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2000. http://dare.uva.nl/document/81828.
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Rhodes, Sinead M. "The neuropsychopharmacology of hyperkinetic disorder (ADHD)." Thesis, University of Dundee, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.288535.
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Tascone, Lyssandra dos Santos. "Morfometria baseada no voxel e sintomas neuropsiquiátricos na Doença de Alzheimer e no comprometimento cognitivo sem demência." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/5/5142/tde-25092013-155146/.
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O estudo dos sintomas neuropsiquiátricos em Doença de Alzheimer (DA) através do agrupamento destes em síndromes tem sido cada vez mais utilizado, uma vez que permitiria detectar diferenças em sua prevalência, em sua evolução, em relação a determinantes psicossociais e a correlatos neurobiológicos. O objetivo deste estudo foi identificar regiões de redução de substância cinzenta em áreas corticais associadas com sintomas e síndromes neuropsiquiátricos específicos, provenientes da Escala Inventário Neuropsiquiátricos (NPI), em pacientes com DA e comprometimento cognitivo sem demência (CIND). O método de morfometria baseada no voxel (VBM) com DARTEL (Diffeomorphic Anatomical Registration Using Exponentiated Lie Algebra) foi utilizado para verificar a correlação entre presença de sintomas e síndromes neuropsiquiátricos específicos e redução regional de volume de substância cinzenta em análise em todo cérebro e em regiões previstas a priori. As síndromes utilizadas foram SN1/Agitação (agitação, alterações de sono e apetite), SN2/Hiperatividade (desinibição, comportamento motor aberrante e irritabilidade), SN3/Afetiva (depressão e apatia) e SN4/Psicose (delírios e alucinações). A presença de delírios foi associada a volume de substância cinzenta reduzido em giro frontal inferior direito (BA45); depressão com xvii redução de substância cinzenta em giro temporal médio e inferior direito (BA 37/22) e giro frontal inferior (BA09-DLPFC) e giro parahipocampal esquerdos; ansiedade com redução em giro frontal médio esquerdo (BA10); e alterações de apetite com redução em córtex anterior cingulado esquerdo (BA32) em pacientes com DA. A presença de SN1/Agitação foi associada a volume de substância cinzenta reduzido em giro frontal médio direito (BA09-DLPFC); SN2/Hiperatividade com redução em giro temporal superior direito (BA22) e frontal inferior bilateral (BA47); e SN4/Psicose com redução em giro pré-central (BA44), temporal superior (BA22) e ínsula direitos em DA. No grupo CIND, somente SN1/Agitação evidenciou associação com redução de substância cinzenta regional. Atrofia de áreas corticais específicas parecem relacionadas aos sintomas e síndromes neuropsiquiátricos em DA. Síndromes neuropsiquiátricas em DA mostraram-se correlacionadas à atrofia de estruturas centrais de alguns circuitos neuronais envolvidos na fisiopatologia de transtornos psiquiátricos<br>The study of neuropsychiatric symptoms in patients with Alzheimer\'s disease (AD) by grouping these symptoms into syndromes has been increasingly used because it would detect differences in its prevalence and evolution, in relation to psychosocial determinants and neurobiological correlates. The aim of this study was to identify regions of reduced gray matter in cortical areas associated with specific neuropsychiatric symptoms and syndromes from the Neuropsychiatric Inventory (NPI) in patients with AD and cognitive impairment, no dementia (CIND). Voxel-based morphometry (VBM) plus Dartel (Diffeomorphic Anatomical Registration Exponentiated Using Lie Algebra) was used to verify the correlation between the presence of specific neuropsychiatric symptoms and syndromes and regional gray matter volume reduction throughout the brain and in regions predicted a priori. The syndromes were NS1/ Agitation (agitation, sleep and eating disorders), NS2/Hyperactivity (disinhibition, aberrant motor behavior and irritability), NS3/Affective (depression and apathy) and NS4/Psychosis (delusions and hallucinations). The presence of delusions was associated with gray matter volume reduction in right inferior frontal gyrus (BA45), depression with reduced gray matter in right inferior middle temporal gyrus (BA 37/22) and left inferior frontal gyrus (BA09-DLPFC) and left parahippocampal gyrus; anxiety with reduction in left middle frontal gyrus (BA10), and eating disorders with reduction in left anterior cingulate cortex (BA32) in patients with AD. The presence of NS1/Agitation was associated with gray matter volume reduction in the right middle frontal gyrus (BA09-DLPFC); NS2/ Hyperactivity with reduction in right superior temporal gyrus (BA22) and bilateral inferior frontal (BA47) and NS4/Psychosis with a reduction in right precentral gyrus (BA44), right superior temporal (BA22) and in right insula in AD. In the CIND group, only SN1/Agitation showed association with regional gray matter reduction. Atrophies of specific cortical areas were showed to be related to symptoms and neuropsychiatric syndromes in patients with AD
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Domingos, Mauricio de Maio. ""O uso da toxina botulínica em doentes com hipercinesia muscular facial contralateral à paralisia facial"." Universidade de São Paulo, 2006. http://www.teses.usp.br/teses/disponiveis/5/5143/tde-17082006-104941/.
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O tratamento da paralisia facial visa recuperar a simetria estática e dinâmica seriamente afetada pela hipercinesia muscular. A toxina botulínica pode ser utilizada em assimetrias faciais. Dezoito doentes foram submetidos à aplicação de 112,5U (0,9ml) de Dysport (toxina botulínica do tipo A), distribuídos nos músculos peribucais. A análise quantitativa das posições estática e dinâmica demonstrou redução significante na hipercinesia por 180 dias. Houve melhora da aparência e satisfação na maioria dos casos. Os eventos adversos foram leves e de curta duração (15 dias), relacionados à dificuldade para beber (9/18) e mastigar (3/18). Como conclusão, a aplicação de toxina botulínica reduziu a hipercinesia facial contralateral à paralisia facial e os doentes ficaram muito satisfeitos com o tratamento<br>The treatment of facial paralysis aims to recover symmetry in both static and dynamic states, seriously affected by the contralateral hyperkinesis. Botulinum toxin may be used to reduce facial asymmetries. Eighteen patients were injected with 112.5 U (0.9 ml) Dysport (Botulinum toxin type A) distributed evenly in the perioral muscles. The quantitative analysis demonstrated a significant reduction in the hyperkinesis for 180 days. Improvement in appearance and satisfaction were found in most of the cases. Adverse events were short-lived (first 15 days) and related to mild difficulty to drink (9/18) and chewing (3/18). Injection of Botulinum toxin was effective in reducing muscular hyperkinesis in the hemiface opposite that affected by facial paralysis and patients were very satisfied with the treatment
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Weeks, Robert Anthony. "Positron emission tomographic studies in hyperkinetic movement disorders." Thesis, Imperial College London, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.368073.
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FORGET, ANNE-PASCALE. "Mise en jeu de la voie metabolique du monoxyde d'azote dans le syndrome hyperkinetique induit par le remplissage au cours du choc endotoxinique du rat." Lille 2, 1994. http://www.theses.fr/1994LIL2M267.
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FLODROPS, ETIENNE. "Apport de la debimetrie cerebrale aux troubles deficitaires de l'attention avec ou sans hyperkinesie." Lille 2, 1993. http://www.theses.fr/1993LIL2M283.
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Lejus-Bourdeau, Corinne. "Association dobutamine noradrenaline pour le traitement du choc septique hyperkinetique post-operatoire en chirurgie digestive." Nantes, 1989. http://www.theses.fr/1989NANT106M.
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Moon, Nathan William. "The amphetamine years a study of the medical applications and extramedical consumption of psychostimulant drugs in the postwar united states, 1945-1980 /." Diss., Atlanta, Ga. : Georgia Institute of Technology, 2009. http://hdl.handle.net/1853/31743.
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Thesis (Ph.D)--History, Technology and Society, Georgia Institute of Technology, 2010.<br>Committee Chair: Tone, Andrea; Committee Member: Flamming, Douglas; Committee Member: Krige, John; Committee Member: Metzl, Jonathan; Committee Member: Usselman, Steven. Part of the SMARTech Electronic Thesis and Dissertation Collection.
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Volodkovič, Stanislava. "Vaikų turinčių hiperkinezinį sindromą socializacijos ypatumai pradinėse klasėse." Master's thesis, Lithuanian Academic Libraries Network (LABT), 2009. http://vddb.library.lt/obj/LT-eLABa-0001:E.02~2009~D_20090630_094115-00810.
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Daugeliui žmonių vaikai yra ne tik didžiausia gyvenimo palaima, bet ir rimčiausias iššūkis. Šioje grupėje ypač išsiskiria negebantys sutelkti dėmesio, judrūs, impulsyvūs vaikai. Kuo labiau padidėjęs vaiko aktyvumas ir impulsyvumas, tuo dažniau jam kyla psichosocialinės adaptacijos sunkumų, ypač vaikų kolektyve. Sutrikusio elgesio, nedėmesingų, impulsyvų vaikų socializacija mokykloje yra svarbi ir sudėtinga pedagoginė problema, kartu tai vienas iš dažniausiai pasitaikančių elgesio ir socialinės raidos sutrikimų tarp vaikų. Išanalizuotoje literatūroje radau, kad visuomenėje yra nuo 3 iki 10 procentų vaikų turinčių hiperkinezinį sindromą. Tirtose mokyklose buvo nustatyta 8% vaikų, turinčių hiperkinezinį sindromą. Nemažas procentas yra impulsyvių, nedėmesingų, neklusnų vaikų. Mokinių, turinčių hiperkinezinį sindromą, tėvai ne visada supranta šio sutrikimo esmę ir dažnai nereaguoja į vaiko hiperaktyvumą, dėmesio stoką ir impulsyvumą. Dauguma vaikų tirtose mokyklose negali pakankamai ilgai susikaupti dėmesį ruošiant pamokas. Tokiems vaikams ne tik sunku paruošti pamokas, bet ir mokytis mokykloje, atlikti tam tikrą veiklą.. Pradinių klasių mokytojai negeba naudotis teisingumu dirbdami su tokiais mokiniais, turinčiais hiperkinezinį sindromą: pernelyg retai vaikas iš anksto supažindinamas su tinkamo elgesio taisyklėmis, retai jam deferencijojamos ir dozuojamos užduotis, vaikas pernelyg retai gauna teigiamą įvertinimą. Mokyklose nėra specialiųjų pedagogu, niekas neužsiima vaiko... [toliau žr. visą tekstą]<br>Problem. Socialisation of primary school pupils with hyperkinetic syndrome.
The object of research. Primary school pupils with hyperkinetic syndrome.
The aim of research. Analyse the peculiarities and problems of socialisation of Polish primary school pupils with hyperkinetic syndrome.
Objectives: 1. To give general characteristics of children with hyperkinetic syndrome.
2. To reveal the problems of Polish – speaking children with hyperkinetic syndrome and suggest some ways to their solution.
3. To define the role of an educator in helping the children with hyperkinetic syndrome.
Most people`s children are not only the greatest blessing but also the most serious challenge. This group includes excessively active and impulsive children with attention – deficit. The more active and impulsive are children, the more often they have psychosocial adaptation difficulties, especially in a children`s group. Socialisation of inattentive, impulsive school children with disruptive behaviour is an important and complicated pedagogical problem. Moreover, it is one of the most often disorders of behaviour and social development in children. Having analysed some literary resources, I have found out that in some western countries, as well as in the USA, there are 3 to 10 per cent of children with hyperkinetic syndrome. Such statistical researches have not been conducted in Lithuania. The research which I have conducted can`t be considered to... [to full text]
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Mokler, Annette Viola. "Okulomotorik bei aufmersamkeitsgestörten, hyperaktiven Kindern nützt bei ADHD ein Training der Blicksteuerung generell oder mit medikamentöser Unterstützung? /." [S.l. : s.n.], 2002. http://www.bsz-bw.de/cgi-bin/xvms.cgi?SWB9793400.
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Giannopoulou, Ioanna. "Preschool hyperactivity : development of observational and self-regulation measures for detecting hyperkinetic disorder in preschool children." Thesis, King's College London (University of London), 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.404417.
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Shue, Karen L. "Attention deficit hyperactivity disorder and the frontal lobe syndrome." Thesis, McGill University, 1989. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=74239.
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The usefulness of frontal lobe (FL) dysfunction as a conceptual model for Attention Deficit Hyperactivity Disorder (ADHD) was investigated. Twenty-four ADHD and 24 normal control (NC) children were tested using tasks sensitive to FL deficits in motor control and problem solving skills and memory tasks sensitive to temporal lobe (TL) dysfunction. ADHD children differed significantly from NCs on measures of FL function, but not on tests of TL functions. Wherever norms were available for normal children on the same FL tests, ADHD subjects performed like 6 to 7 year olds, in spite of their mean age of 10 years and minimum age of 8 years. The differential performance of ADHD children on tasks sensitive to FL and TL damage supports the conceptualization of ADHD deficits as analogous to FL dysfunction and implies that deficits are not explained by reference to generalized impairment.
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Owens, Chase. "A Constructional Approach to Establishing and Maintaining Calm Canine Behavior." Thesis, University of North Texas, 2017. https://digital.library.unt.edu/ark:/67531/metadc984128/.
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Very few behavior-change programs with canines produce effects that persist beyond the training condition. The present study is an experimental demonstration of a constructional program that established calm patterns of behavior as alternatives to hyperactive ones. Three dogs that exhibited hyperactive patterns were chosen as subjects. Seven conditions common to canine-caretaker relationships were used to determine which factors resulted in the hyperactive patterns. Then, sitting and lying down were taught as beginning points using touch as a reinforcer. The final behavior, maintained by naturally occurring reinforcers, was established errorlessly. The study used a control-analysis strategy of behavior change with a changing-criterion design. The intervention resulted in an immediate reduction in hyperactivity and an increase in sitting and lying down for all dogs.
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Reinholdt, Marie. "ADHD in historical and comparative perspective : medical, educational and public approaches to childhood hyperactivity in the US and the UK, 1960-2010." Thesis, University of Manchester, 2013. https://www.research.manchester.ac.uk/portal/en/theses/adhd-in-historical-and-comparative-perspective-medical-educational-and-public-approaches-to-childhood-hyperactivity-in-the-us-and-the-uk-19602010(d5fba2b2-03ef-4b5b-a851-9264b95ec58a).html.
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Adding a much needed historical and comparative dimension to current debates about Attention Deficit Hyperactivity Disorder (ADHD), the present thesis provides an analysis of the changing construction and treatment of childhood hyperactivity in Britain and the United States, focusing on the period from 1960 to 2010. The focal point is the historical discrepancy between the two countries in diagnostic and therapeutic practices, and the question of how and why perspectives have increasingly converged over the past 20 years. Whereas British medical and educational professionals continued to rely on environmental explanations and interventions for the vast bulk of disruptive behaviour in school children, the American concept of hyperactivity disorder from the 1960s onwards became increasingly inclusive and biomedical in orientation. This expansion was closely related to the rise of psycho-stimulants as a widely employed treatment for hyperactivity and attention problems in the US. British and other European clinicians, on the other hand, resisted drug treatments up until the mid-1990s, when rates of diagnosis and prescription grew dramatically on both sides of the Atlantic. A key aim of this study is to explore and explain the rise of ADHD and Ritalin in both the American and British contexts, looking at the interplay of political, professional, institutional and socio-cultural factors that have contributed in each case. The study concentrates on three distinct but interconnected spheres which, both separately and in combination, have underpinned and shaped approaches to hyperactivity in the two countries: medicine, education and the wider public arena, represented by parent support groups. While chapters 2, 3 and 4 focus on the medical debates and practices surrounding hyperactivity, and the points of connection and disconnection between the two medico-psychiatric communities, chapters 5 and 6 examine the role of schooling, disability activism, and educational policy, especially that relating to special educational needs. Finally, chapter 7 explores the issue of parent activism which has been an important factor in the growth and critique of ADHD in both settings.
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Kim, Samuel Doohwan. "Clinical and Neurophysiological correlates of cortical excitability changes studied using the cortical threshold tracking TMS in hyperkinetic and hypokinetic movement disorders." Thesis, The University of Sydney, 2015. http://hdl.handle.net/2123/13645.
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This thesis attempts to answer the question, “what is the significance of abnormal cortical excitability studies in movement disorders?” Remarkably similar cortical excitability findings have been reported in Parkinson's disease (PD) and Stiff-man syndrome (SMS) despite these disorders manifesting with hypokinetic and hyperkinetic movement disorders, respectively. In SMS patients, there was a significant reduction in short intracortical inhibition (SICI) with dissociation between the measures of cortical and spinal excitability and clinical measures of disease severity and plasma levels of anti-GAD antibodies. The results suggest that spinal hyperexcitability and muscle stiffness and spasms are unlikely to be simply due to cortical disinhibition of spinal circuits. In PD patients, there was a significant reduction in SICI and intracortical inhibition (ICF) which appeared to be dependent on disease severity and plasma levodopa levels. Most significant findings were detected in those who had been on long term levodopa carbidopa intestinal gel (LCIG) treatment. Specifically, there was a lack of decrement in hand tapping speed, an objective measure of bradykinesia, despite a significant reduction in matching plasma levodopa levels and SICI. These results raise the possibility of restoration of the long duration effect of levodopa as a result of sustained continuous dopaminergic therapy. This thesis confirms there is much value in further careful research of cortical excitability changes in Parkinson’s disease and other related movement disorders.
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McCairn, Kevin William. "The Behavioral and Neuronal Correlates of Basal Ganglia Hypo and Hyperkinetic Motor Disorders and their Response to Deep Brain Stimulation in Non Human Primates." Thesis, Open University, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.518374.
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Costa, Ursula Thomé. "Correlação entre semiologia clínica e achados do SPECT ictal nas crises epilépticas hipercinéticas." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/17/17140/tde-05012017-093747/.
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INTRODUÇÃO: A classificação recente das Crises Hipercinéticas (CH) proposta por Rheims et al. (2008) sugere dois padrões de CH, baseado na semiologia ictal (Tipos I e II): no Tipo I, a zona epileptogênica foi identificada na região ventral pré-frontal, enquanto que no Tipo II, na região mesial pré-motora. Estudos com SPECT ictal em pacientes com CH evidenciaram hiperperfusão nas regiões frontais e extrafrontais, incluindo ínsula e lobo temporal, além de áreas subcorticais, tais como cerebelo, tálamo, gânglios da base e tronco encefálico. OBJETIVO: Avaliar a rede neural ativada nas CH através do SPECT ictal, correlacionando-a aos dois subtipos de CH (Tipos I e II). MATERIAL E MÉTODOS: Uma amostra de 25 pacientes com idade entre 0 e 60 anos com CH que realizaram SPECT ictal foi submetida a análise do VEEG e das imagens do SPECT ictal a fim de determinar o tipo de CH e as áreas de hiperpefusão ativadas, bem como sua correlação. RESULTADOS: Nove pacientes (36%) tiveram CH do Tipo I, dez (40%), do Tipo II e seis (24%), do Tipo Misto. Não houve diferenças significativas entre os tipos de CH e a presença de semiologia ictal não hipercinética durante as crises, bem como o tempo de doença, frequência das crises, história familiar positiva e exame de neuroimagem anormal. A duração média do tempo de injeção do RF foi de 32,2 segundos. O SPECT demonstrou ativação difusa, com predomínio nas regiões subcorticais, temporal lateral, occipital mesial e frontal dorsolateral. Não houve correlação entre os diferentes tipos de CH e as áreas hiperperfundidas, exceto pela região occipital mesial, que foi significativamente maior no Tipo II. CONCLUSÃO: A classificação proposta por Rheims et al. (2008) é útil porém simplista, já que as CH abrangem uma fenomenologia complexa, não sendo possível classificar todos os pacientes em somente dois tipos (I e II). O SPECT ictal nesta amostra demonstrou a presença de hiperperfusão em diferentes áreas cerebrais, reforçando a hipótese de que uma rede neural ampla, que engloba as regiões frontais e possivelmente extrafrontais, incluindo áreas subcorticais, está envolvida na gênese destas crises.<br>BACKGROUND: The recent classification of hyperkinetic seizures (HS) proposed by Reims et al (2008) suggests two patterns of HS based on ictal symptomatology (Type I and II), whereas in Type I epileptogenic zone was identified in the ventromesial frontal córtex while in Type II, in the mesial premotor córtex. Ictal SPECT studies in patients with HS showed hyperperfusion in frontal and extrafrontal regions, including insula and temporal lobe, and subcortical areas, such as cerebellum, thalamus, basal ganglia and brain stem. OBJECTIVE: To evaluate the neural network activated in HS through the ictal SPECT and to correlate it to the two subtypes of HS (Type I and II). METHODS: We retrospective analyzed ictal signs and ictal SPECT data in 25 patients with HS aged between 0 and 60 years in order to determine the type of HS and the hyperperfused areas, as well as their correlation. RESULTS: Nine patients (36%) were classified as Type I, ten (40%) as Type II and 6 (24%) as a mixed type. There were no significant differences between the types of HS and the presence of non-hyperkinetic ictal semiology, as well as epilepsy duration, frequency of seizures, positive family history and abnormal neuroimage. The average injection duration time was 32.2 seconds. The ictal SPECT showed diffuse activation, predominantly in subcortical regions and the following areas: lateral temporal, mesial occipital and dorsolateral frontal cortex. There was no correlation between the different types of HS and the hyperperfused areas but the mesial occipital region that was significantly higher in Type II. CONCLUSION: The classification proposed by Rheims et al (2008) is useful but simplistic. Since the HS consists of a complex phenomenology, it is not possible to classify all patients in only two types (I and II). The ictal SPECT in this sample showed the presence of hyperperfusion in different brain areas, reinforcing the hypothesis that a broad neural network, which includes the frontal and possibly extrafrontal regions, including subcortical areas, are involved in the genesis of these seizures.
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Mucha, Ján. "Akustická analýza přednesu básně u pacientů s Parkinsonovou nemocí." Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2016. http://www.nusl.cz/ntk/nusl-241984.
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Diploma thesis is focused on the acoustic analysis of poetry recitation in patients with Parkinson's disease. This disease is associated with speech disorder called hypokinetic dysarthria. One objective of this thesis was familiarization with process, symptoms and treatment of these diseases. In thesis is described preprocessing and parametrization of the speech signal and the binary classification methods. Subsequently, it is the above proposal modular system of auto-diagnosis of Parkinson's disease based on acoustic analysis of the speech. The proposed system is implemented in MATLAB. Classification of calculated parameters is realized using the method of Random forest and Support vector machine. The results of these methods are compared and listed in the thesis. The main objective and the result of this thesis is a system of automatic diagnosis of Parkinson's disease based on acoustic analysis of the poem recitation.
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LONGO, FRANCESCO. "Altered motor phenotype and dopamine transmission associated with mutations of the parkinsonian gene LRRK2." Doctoral thesis, Università degli studi di Ferrara, 2015. http://hdl.handle.net/11392/2389103.
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The leucine-rich repeat kinase 2 mutation (LRRK2) G2019S in the kinase-domain is the most common genetic cause of late-onset autosomal dominant Parkinson’s Disease (PD), occurring in >85% of patients carrying this LRRK2 mutation. LRRK2-related PD is clinically indistinguishable from the classic idiopathic form, being characterized by classic neuropathological hallmarks such as progressive degeneration of the substantia nigra pars compacta (SNpc) dopaminergic neurons, gliosis and α-synuclein and ubiquitine-positive intraneuronal cytoplasmic inclusions.
The main goal of this thesis work was to evaluate the role played by the kinase function of LRRK2 in the expression of motor phenotype and dopamine transmission in mice, since transgenic models reported so far failed to recapitulate the parkinsonian phenotype and its neuropathology. To directly explore the impact of the kinase-enhancing G2019S mutation on motor activity in vivo, a longitudinal phenotyping approach was developed. We enrolled two cohorts of G2019S knock-in (KI) mice and wild-type littermates (WT) and analyzed their motor activity at different ages (3, 6, 10, 15 and 19 months) using a set of complementary behavioral tests, specific for akinesia, bradykinesia and overall gait ability. Our study revealed that G2019S KI mice motor performance remained stable up to the age of 19 months and did not show the typical age-related decline in immobility time and stepping activity of WT. To confirm that enhanced kinase activity accounts for this phenotype, we adopted a combined genetic and pharmacological approach. On one hand we performed a parallel longitudinal study in mice carrying a LRRK2 mutation (D1994S) that impairs kinase activity (kinase-dead, D1994S KD), on the other hand we administered two LRRK2 kinase inhibitors (H-1152 and Nov-LRRK2-11) in G2019S mice. We found that i) KD mice were not phenotypic and ii) LRRK2 inhibitors reversed the hyperkinetic phenotype of G2019S KI mice, while being ineffective in WT or in D1994S KD animals. In vivo LRRK2 targeting of kinase inhibitors was further substantiated by the reduction of LRRK2 phosphorylation at Ser935 in the striatum and/or cortex at efficacious doses of LRRK2 inhibitors.
In order to investigate whether the hyperkinetic phenotype of G2019S mice was associated with dysfunction of striatal dopamine neurotransmission, we carried out a series of behavioral, biochemical, and neurochemical experiments. No changes in nigral dopamine cell counts or dopamine striatal density were observed in G2019S mice. However, the overall pattern of responses to a D2/D3 receptor agonist or antagonists and to D1/D5 receptor antagonists suggested an elevated tonic activation of dopamine receptors in G2019S KI mice. Furthermore, blockade of the dopamine transporter (DAT) resulted in an enhancement of motor performance of WT but not G2019S KI mice. Results from in
vitro binding assays revealed a reduction in the DAT protein levels which was associated with an increased dopamine reuptake in G2019S KI mice. In vivo microdialysis showed a reduced metabolites/dopamine ratio in in the striatum of G2019S mice, suggesting a reduced dopamine turnover. Overall the data provide genetic and pharmacological evidence that the kinase activity of LRRK2 is highly implicated in the modulation of motor activity along with the striatal dopaminergic system. However, whether and how the observed changes in motor phenotype and dopamine transmission translate into the overt parkinsonian pathology remains a matter for speculation. It is also possible that G2019S KI mice reflect a pre-symptomatic stage of the disease, as observed in other genetic models of PD. Nonetheless, the present thesis work proposes G2019S KI mice as a valuable in vivo model to investigate the effects of LRRK2 inhibitors.
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Campbell, Nicole Githa. "The central auditory processing and continuous performance of children with attention deficit hyperactivity disorder (ADHD) in the medicated and non-medicated state." Thesis, Pretoria : [s.n.], 2003. http://upetd.up.ac.za/thesis/available/etd-09302005-104833.
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Cavallin, Mara. "Physiopathologie moléculaire et cellulaire des anomalies du développement du cortex cérébral : le syndrome d'Aicardi WDR81 mutations cause extreme microcephaly and impair mitotic progression in human fibroblasts and Drosophila neural stem cells TLE1, a key player in neurogenesis, a new candidate gene for autosomal recessive postnatal microcephaly Mutations in TBR1 gene leads to cortical malformations and intellectual disability Aicardi syndrome: Exome, genome and RNA-sequencing of a large cohort of 19 patients failed to detect the genetic cause Recurrent RTTN mutation leading to severe microcephaly, polymicrogyria and growth restriction Recurrent KIF2A mutations are responsible for classic lissencephaly Recurrent KIF5C mutation leading to frontal pachygyria without microcephaly Rare ACTG1 variants in fetal microlissencephaly De novo TUBB2B mutation causes fetal akinesia deformation sequence with microlissencephaly: An unusual presentation of tubulinopathy A novel recurrent LIS1 splice site mutation in classic lissencephaly Further refinement of COL4A1 and COL4A2 related cortical malformations Prenatal and postnatal presentations of corpus callosum agenesis with polymicrogyria caused By EGP5 mutation Delineating FOXG1 syndrome from congenital microcephaly to hyperkinetic encephalopathy Delineating FOXG1 syndrome: From congenital microcephaly to hyperkinetic encephalopathy." Thesis, Sorbonne Paris Cité, 2019. https://wo.app.u-paris.fr/cgi-bin/WebObjects/TheseWeb.woa/wa/show?t=2213&f=18201.
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Les malformations du cortex cérébral (MDC) représentent une cause importante de handicap et d'épilepsie pharmaco-résistante. Le séquençage à haut débit a permis une amélioration considérable de l'identification des bases moléculaires des MDC non syndromiques. Toutefois, certaines formes, notamment les MDC complexes, demeurent inexpliquées. Mon projet de thèse a pour objectif de progresser dans la compréhension des MDC complexes en utilisant deux modèles : les microlissencéphalies (MLIS) et le syndrome d'Aicardi (AIC), une forme syndromique particulière associant des malformations de l'oeil et du cerveau uniquement rapporté chez les filles. L'étude par séquençage d'exome en trios de 16 familles MLIS m'a permis d'identifier et de caractériser un nouveau gène, WDR81, impliqué dans le cycle cellulaire. Par la même stratégie, j'ai pu identifier un variant homozygote pathogène dans TLE1, un partenaire majeur de FOXG1 dans la balance prolifération/différenciation de progéniteurs neuronaux, dans une famille consanguine de microcéphalie postnatale dont le phénotype est proche du syndrome FOXG1. En parallèle, mes travaux ont permis de préciser les spectres phénotypiques associés à RTTN, EPG5, COL4A1, COL4A2, TBR1, KIF5C, KIF2A et FOXG1. La deuxième partie de mon projet avait pour objet l'identification des bases moléculaires du syndrome d'Aicardi à partir d'une cohorte internationale de 19 patientes. Après avoir exclu un biais d'inactivation du chromosome X et la présence de microremaniements chromosomiques, j'ai réalisé un séquençage d'exome en trio. Aucun variant récurrent n'a été retrouvé dans les séquences codantes. Dans un second temps, j'ai testé une approche combinant les données du séquençage de génome et l'analyse du transcriptome (RNA-Seq) sur fibroblastes, me permettant d'identifier des transcrits dérégulés qui étaient impliqués dans le développement du cerveau et de l'oeil. J'ai comparé les résultats de cette analyse avec ceux de l'analyse du génome dans le but d'identifier des variants dans ces gènes candidats. En conclusion, mon travail de thèse a permis d'améliorer la connaissance des bases moléculaires des MDC complexes et d'ouvrir des perspectives de nouveaux mécanismes tels que ceux engageant les gènes WDR81 et EPG5, et le rôle des endosomes et de l'autophagie dans les MDC, et aussi TLE1 comme nouvelle cause de microcéphalies postnatales. Mes travaux ont également permis de générer une collection de données de séquençage haut débit (WES, WGS et RNA-Seq) qui seront mises en commun dans le cadre d'un consortium international afin de développer des nouvelles stratégies d'analyse en particulier pour les séquences non codantes. Cette approche permettra également d'ouvrir la voie vers la compréhension des mécanismes cellulaires impliqués dans la formation du cerveau et de l' œil<br>Malformations of cortical development (MCD) are a major cause of intellectual disability and drug-resistant epilepsy. Next Generation Sequencing (NGS) has considerably improved the identification of the molecular basis of non-syndromic MCD. However, certain forms, including complex MCD, remain unexplained. My PhD project aimed to improve the understanding of complex MCD using two disorders: Microlissencephaly (MLIS) and Aicardi Syndrome (AIC), the latter associating brain and eye malformations and only reported in girls. Trio Whole Exome Sequencing (WES) performed in 16 MLIS families allowed me to identify and functionally characterize a new MLIS gene, WDR81, in which mutations lead to cell cycle alteration. Moreover, using the same strategy, I was able to identify a pathogenic homozygous variant in TLE1 in a patient from consanguineous family with a postnatal microcephaly, suggestive of a FOXG1-like presentation. Interestingly, TLE1 is a major partner of FOXG1, a gene involved in maintaining the balance between progenitor proliferation and differentiation. In parallel, my work allowed me to redefine the phenotypic spectrum associated with RTTN, EPG5, COL4A1 and COL4A2, TBR1, KIF5C, KIF2A and FOXG1. The second part of my PhD program was aimed at identifying the genetic basis of AIC in an international cohort of 19 patients. After excluding a skewed X chromosome inactivation and the presence of chromosomal rearrangements, I performed WES in trios. The analysis of the data from WES did not allow me to identify any recurrent variants. I therefore tested a new approach combining Whole Genome Sequencing (WGS) and RNA-Sequencing (RNA-Seq) on fibroblast cells. I identified a number of deregulated transcripts implicated in brain and eye development. I compared the results of this analysis with the WGS analysis in order to find variants in these candidate genes. In conclusion, these studies have improved the knowledge of the molecular basis of complex MCD, such as TLE1 in postnatal microcephaly, and revealed the pathogenic mechanisms such as WDR81 in cell cycle progression and EPG5 in endosomes and autophagy. My work has also generated a collection of NGS data (WES, WGS and RNA-Seq) that will be shared in an international consortium to develop new analytical strategies, in particular for the non-coding DNA regions. This novel strategy provides opportunities to improve understanding of the cellular mechanisms involved in brain and eye development
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Dvořák, Jiří. "Biofeedback a jeho použití." Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2009. http://www.nusl.cz/ntk/nusl-217977.
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The aim of this work is describe common methods of biological feedback therapy that is used to treat some psychosomatic diseases. Subsequently, the description is focused on minimal brain dysfunction treatment by the help of EEG biofeedback. Properties and technical requirements for this therapy are concretized. The last part of this thesis is dedicated to the design and realization of practical software tool for EEG biofeedback therapy which is made in LabView 7.1. The M535 acquisition unit and NI USB-6221 measuring device are used for hardware solution.
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Liu, Yu-Hsiang, and 劉毓翔. "Medicalization of Hyperkinesis in Media Discourses." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/93452572374953966157.
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碩士<br>輔仁大學<br>社會學系碩士班<br>103<br>In the present society, despite the spread and influence of medicalization in everyday life, the diagnosis and treatment of Hyperkinesis is still a very controversial and complex subject. By using analysis and media discourses of Hyperkinesis, this research hopes to provide readers with an understanding of the subject, and overcome the arguments and controversies created by practicing medicalization with regards to Hyperkinesis. In addition to this, a preliminary discourse to sort out the trend of practicing medicalisation to Hyperkinesis will be provided in brief.
The methods used in this research are Content analysis, and Participant Observation. By cross examining the topic through the lens of multiple theories, one can cover up the short ends of each research methods while ensuring one specific method does not bias the final result and content.
The main research findings are as follow: First, the data clearly shows that domestically, the public discussions regarding Hyperkinesis is mostly consistent with the trend of medicalization processing of the ailment. In the case of Taiwan, by means of Discourse Analysis, one can clearly sees the sequence of using Behavior Therapy as the main treatment, slowly progressing to a reliance on medicalization.
Secondly, in terms of Hyperkinesias, the mainstream Psychiatry still dominates the discourse. However the so-called non-mainstream discourse (e.g. TCM, Rehabilitation) still have its unique purpose, possessing the value of further research in depth. In the mean time, the position of where these non-mainstream stands is essentially highlighting the doubts concerning the mainstream Psychiatry and the suspicious attitude towards mental drugs usages. Like with TCM, a possible solution for Hyperkinesias could be done via combining special tutoring and careful nursing.
During the course of studying Hyperkinesias, one discovers that its poor reputation is deliberately embedded within those professional discussions and careful elaborations. In the case of professional medical discussion, when it desires to increase attendance rate, then it emphasize strongly the side effect of not seeking any medical advice, including the violent behaviors and anti-sociality characteristic that might emerge in the future. However, when the situation turns the other way, it will then stress out the point that the patients are actually not that awful; people should not consider them as violent and wild. The foul-name of Hyperkinesias, seen to be utilize as only the method and tool of professional discussions, the possible issues of dis-reputing Hyperkinesias appears to be seen as not of importance.
In the end, if hoping to solve the blame game caused by all the interweaving of different expounds surrounding Hyperkinesias, one will have to remove themselves from the current narrative, and look beyond the system. By using the child itself as the reference point, one must reconsider all the related questions and systems. Only in this way will there come a possibility of the three professions (Parents, Education, and Medical) all working together, or else it will remain a zero sum game where nobody wins. In which case, answer to the questions posed will be lost forever.
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Stiles, Enid K. "Physiological and behavioural effects of dextroamphetamine on Beagle dogs : a placebo controlled study." Thèse, 2010. http://hdl.handle.net/1866/3958.
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Plusieurs articles scientifiques et manuels de référence en médecine comportementale distinguent l'hyperactivité ou hyperkinésie de l’activité excessive en évaluant la réponse physiologique et comportementale des chiens suite à l’administration per os de 0.2 à 1.0 mg/kg de dextroamphétamine. Selon ces références, le chien atteint d’un syndrome hyperactif ou hyperkinésie, répondra de façon paradoxale à cette médication par une diminution de l’activité motrice accompagnée d’une réduction minimale de 15% de la fréquence respiratoire et de la fréquence cardiaque. L’objectif de la présente étude était de mesurer la variation de la température corporelle, de la fréquence cardiaque, de l’activité motrice et de différents comportements spécifiques chez un groupe de Beagles ayant reçu de la dextroamphétamine. La fiabilité d'un accéléromètre comme mesure objective d’activité motrice a aussi été évaluée.
Dans le cadre de cette étude croisée contrôlée par placebo, douze Beagles de la colonie de recherche âgés entre 13 et 20 mois ont reçu une dose orale de 0.2 mg/kg de dextroamphétamine. Le moniteur cardiaque Polar® et un accéléromètre Actical® ont été utilisés pour enregistrer la fréquence cardiaque et l’activité motrice avant et après l’administration de la médication. La durée de chacun des comportements spécifiques a été compilée à l’aide du logiciel Noldus® et la température corporelle a été prise par thermomètre rectal. Le modèle équilibré de mesures répétées indique que les sujets ayant reçu la dextroamphétamine montrent une réduction significative (p = 0.044) de leur fréquence cardiaque comparativement aux chiens ayant reçu le placebo. Aucune variation significative n'a été observée concernant la température corporelle, l'activité motrice, et les autres comportements (léchage des babines, halètements, et bâillements) suite à l’administration de la dextroamphétamine. Une corrélation significative, linéaire et positive (p < 0,0001) entre les périodes de mouvements observées (vidéo) et les mesures d’activité enregistrées par l’accéléromètre a été observée. Les résultats de cette étude indiquent que les Beagles peuvent afficher des effets paradoxaux dans les 90 minutes suivant l’administration per os de dextroamphétamine à raison de 0.2 mg/kg.<br>Several veterinary behaviour texts/handbooks used in practice, distinguish hyperactivity or hyperkinesis from over-activity by using the physiological and behavioural responses of dogs given amphetamines. It is presumed that true hyperactive or hyperkinetic dogs given 0.2 - 1.0 mg/kg dextroamphetamine orally will paradoxically calm down, and have at least a 15% reduction in heart and respiratory rates. The purpose of the study was to measure the effects of an oral dose of 0.2 mg/kg dextroamphetamine on heart rate, body temperature, motor activity, and discrete behaviour sequences in Beagle dogs. Reliability of a collar mounted accelerometer, Actical® as an objective measure of motor activity was also investigated.
The study design was a placebo controlled cross-over study. Twelve research colony Beagle dogs (13 - 20 months old) received an oral dose of 0.2 mg/kg dextroamphetamine as treatment. Baseline and post-treatment values for body temperature, heart rate, motor activity, and general behavioural changes, were obtained using rectal temperature, video recordings and Noldus® software, Polar® monitor (heart rate), and a collar mounted Actical®. A repeated measures model indicates that dogs receiving an oral dose of 0.2 mg/kg dextroamphetamine had a significantly (p = 0.044) reduced heart rate compared to placebo. There was no effect of treatment on the dogs’ body temperature, motor activity, or other behaviours such as “lip-licking”, “panting” and “yawning”. There is a significant linear and positive relationship between the gross motor activity as measured by observational video and the Actical® counts (p < 0.0001). Results from this study indicate that Beagle dogs may display some paradoxical effects in the 90 minutes following an oral dose of 0.2 mg/kg dextroamphetamine.
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Archibald, Sarah Jane. "Understanding physical overactivity in ADHD: utilization behavior." Thesis, 2000. https://dspace.library.uvic.ca//handle/1828/9917.
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The primary purpose of this study was to provide a better understanding of the typology and etiology of physical overactivity (hyperactivity) in ADHD. ADHD is uniquely characterized by inappropriate/excessive motor activity, yet motoric aspects of ADHD have been neglected in the research literature. Given high levels of intrusive/inappropriate motor behaviors and evidence that the neuropathology of ADHD involves frontal-striatal dysfunction, this study investigated the possibility that aspects of physical overactivity in ADHD could be a result of a “utilization behavior syndrome”.
Theories of this utilization behavior that claim the syndrome results from an imbalance between medial (frontal; voluntary, goal-directed) and lateral (parietal/visual; automatic, reactive) motor systems were also addressed. Results revealed high levels of utilization behavior specifically characterize hyperactivity in ADHD, and that motor overactivity in ADHD is not simply a result of generally heightened activity levels. Levels of utilization behavior were statistically associated with severity of hyperactive symptomatology as reported by parents of children with ADHD. Furthermore, utilization behavior was significantly related to difficulties on tasks thought to be dependent on the functioning of the medial but not the lateral, motor system. This supports theories that utilization behavior, at least in ADHD, could be a result of disinhibition of the lateral motor system due to dysfunction within the medial motor system.<br>Graduate
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McCarthy, Andrea. "An Integrated Approach to Detecting Communicative Intent amid Hyperkinetic Movements in Children." Thesis, 2010. http://hdl.handle.net/1807/25854.
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Hyperkinetic movement (HKM) can encumber nonverbal communication of preference. Caregiver and clinician interpretation of preference are recognized as a valuable but limited proxy translation. It is known that biomechanical signals can differentiate among movement patterns in various populations. We hypothesize that preference is encoded in HKM; to test this hypothesis we propose a unified approach to detect preference within HKM, fusing observational and quantitative techniques while incorporating caregiver and clinician perspectives. We illustrate this method through two case studies; in the first case preference is detectable by both visual (fair agreement) and accelerometer classification (68.5% accuracy) whereas in the second case preference is only detectable by accelerometer-based classification with 62.9% accuracy. The proposed procedure may enable researchers to effectively explore communicative movement patterns in children with HKM. The findings warrant further investigation into potential communicative patterns in HKM.
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Thanendrarajan, Sharmilan [Verfasser]. "Graphimetrie : eine neue computerunterstützte Methode zur Quantifizierung von Hyperkinesien bei der Huntington-Krankheit / vorgelegt von Sharmilan Thanendrarajan." 2009. http://d-nb.info/999828533/34.
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PAPARELLA, GIULIA. "Bradykinesia in non-parkinsonian conditions: the emerging concept of a network disorder." Doctoral thesis, 2021. http://hdl.handle.net/11573/1542446.
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Bradykinesia (movement slowness) is one of the cardinal motor symptoms of Parkinson‟s disease and atypical parkinsonism and it has hystorically been interpreted as a motor disorder due to basal ganglia dysfunction. Clinical and experimental studies, however, indicate that it may be also observed in the context of various neurological conditions not primarily characterized by parkinsonism. These conditions include hyperkinetic movement disorders, such as dystonia and chorea, as well conditions primarily characterized by tremor (e.g. essential tremor) or other nervous diseases characterized by the involvement of brain areas and network including not only the basal ganglia but also the cerebellum and upper motoneurons. Also, movement slowness may be observed in patients with neurodegenerative or inflammatory diseases of the central nervous system of various origins, like dementia or multiple sclerosis. From a pathophysiological standpoint, the observation of movement slowness in neurological conditions not primarily characterized by parkinsonism is possibly explained by a brain network dysfunction, as hypothesized in parkinsonism. In the present thesis, we will first provide an updated overview on bradykinesia in non-parkinsonian conditions and discuss major findings of clinical reports and experimental studies. In the experimental part of the present thesis, we will provide the results from three original studies, which investigated the presence of bradykinesia and its possible pathophysiological mechanisms in (i) patients with essential tremor, (ii) patients with Alzheimer‟s disease, and (iii) patients with amyotrophic lateral sclerosis. Finally, we will provide a unifying pathophysiological interpretation of bradykinesia in non-parkinsonian conditions from a network perspective and emphasize possible terminological implications.
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ARNICANOVÁ, Zuzana. "Hyperaktivní a "hyperaktivní" dítě ve škole." Master's thesis, 2014. http://www.nusl.cz/ntk/nusl-170180.
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Dissertation focus on problems connected with ADHD and hyperkinetic disorder. First part describes ADHD, it?s symptoms, utterances in different parts of children?s evolution, diagnosis and treatment. Main part focuses on foreknowledge, right usage of term ADHD and hyperactivity of different groups of people. As next, it focuses on finding how is the situation with recognizing of ADHD and diagnosis and consecutive work with these children.
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Valeriánová, Anna. "Kardiovaskulární komplikace u pacientů s chronickým renálním onemocněním." Doctoral thesis, 2019. http://www.nusl.cz/ntk/nusl-408893.
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Patients with end-stage renal disease frequently suffer from cardiovascular complications. Many factors contribute to their development: hyperkinetic circulation caused by anaemia, fluid retention and by presence of dialysis arteriovenous access; metabolic changes leading to acceleration of atherosclerosis and increase of vascular stiffness and also fluctuation of blood pressure and organ perfusion during haemodialysis, that cause repeated tissue hypoxia. We performed our research on patients in chronic haemodialysis programme. The project studying long-term patency of dialysis access showed that dialysis graft patency is negatively influenced by presence of coronary artery disease and low serum concentrations of cholesterol. In our studies about tissue hypoxia we proved that haemodialysis patients suffer from hypoxia of cerebral tissue and muscle tissue of the dialysis access arm, and that the hypoxia worsens during dialysis. Factors associated with brain hypoxia are presence of heart failure, higher BNP levels and higher erythrocyte distribution width. One of the serious consequences of brain hypoxia is development of cognitive deficit. Among the negative impact of haemodialysis on the heart, we observed left atrial dysfunction, which is a consequence of long-term remodelling and cannot be...
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VETCHÁ, Veronika. "ADHD v MŠ - jak se rodí diagnóza." Master's thesis, 2010. http://www.nusl.cz/ntk/nusl-53426.
Full textAbstract:
The thesis is focuced on the origin of the syndrom ADHD and its influence and impact on ensuant life of the pre-schoolers in kindergarten. The main terms connected with ADHD are explained at the beginning of the work, containig terminology, partial symptoms such as hyperaktivity, impulsivity and attention deficit, atc. Furthermore, there are mentioned its possible etiologies, various ways of rectification and treatment and convenient and professional approaches to hyperactive children. The describtion of the the procedures and ways of the revealing and later professional assignment of the diagnosis of this disorder is also mentioned in these thesis. The practical part of the thesis is focused just on the proces and proceeding to the professional assignment of ADHD and its causes and circumstances for this decision , who did that and how the diagnosis influenced life of that child and his/her surroundings.
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Wardle, Wilna Jeanne. "Aandagtekortversteuring met en sonder hiperaktiwiteit : 'n neurosielkundige ondersoek na verskille in die onderliggende elemente van aandag." Diss., 1998. http://hdl.handle.net/10500/17843.
Full textAbstract:
Text in Afrikaans<br>Hierdie studie ondersoek die moontlikheid dat aandagtekort
versteuring met hiperaktiwiteit(ATHV/H) verband hou met probleme
met voortgesette aandag, terwyl aandagtekort versteuring sander
hiperaktiwiteit(ATHV/SO) verband hou met probleme met gefokusde
aandag. Neurosielkundige toetse waarmee voortgesette- en
gefokusde aandag gemeet word, word gebruik om drie groepe,
naamlik ATHV/H(n=24), ATHV/SO(n=l5) en 'n kontrole groep(n=21),
met mekaar te vergelyk. Resul tate dui daarop dat die groep
ATHV/SO beduidend swakker presteer as die ander twee groepe op
sommige van die toetse van gefokusde aandag, en ook neig om
swakker te presteer op die toets van voortgesette aandag. Die
groep ATHV/SO se probleme blyk gekoppel te wees aan 'n stadiger
spoed van kognitiewe prosessering en 'n toestand van hipoopwekking.
Die groep ATHV/H presteer nie beduidend swakker as
die ander twee groepe op die toets van voortgesette aandag nie,
maar presteer wel swakker as die kontrole groep op die Stroop
Colour-Word Test waar inhibisie van ontoepaslike response vereis
word. Die groep ATHV /H se probleme blyk verband te hou met
frontale disfunksie wat manifesteer as 'n neighing tot impulsiwiteit en gebrekkige gedragsregulering.<br>This study examined the possibility that attention deficit
disorder with hyperactivity(ADHD/H) is related to problems with
sustained attention, while attention deficit disorder without
hyperactivity (ADHD/WO) is related to problems with focussed
attention. The performance of three groups: ADHD/H (n=24),
ADHD/WO(n=15) and a control group(n=21) were compared. Results
indicated that the ADHD/WO group performed significantly poorer
than the other two groups on some of the tests of focussed
attention and also tended to perform poorer on the test assessing
sustained attention. This groups' symtoms appear to be related
to a slowed speed of processing and a state of hypo-arousal. The
ADHD/H group did not perform poorer than the other two groups on
the test assessing sustained attention. The ADHD/H groups'
symptoms appear to be related to frontal dysfunction resulting in impulsivity and poor behavioural control.<br>Psychology<br>M.A. (Sielkunde)