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Journal articles on the topic 'Hyperlipidemic'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Fuzeti Gonçalves Netto, Marcela, Gabryella Fraga Ramos Mello, and Viviani De Marco. "Evaluation of the frequency of fasting and postprandial hyperlipidemia in healthy Schnauzers and of hepatic changes and insulin resistance in hyperlipidemic Schnauzers." Clínica Veterinária XXIII, no. 137 (2018): 24–30. http://dx.doi.org/10.46958/rcv.2018.xxiii.n.137.p.24-30.

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Hyperlipidemia in dogs can be primary or secondary. Secondary hyperlipidemia is the most frequent form, and it is associated to endocrine disorders, obesity, and glucocorticoid therapy. Primary hypertriglyceridemia of Miniature Schnauzers is a well-known condition and may predispose to the development of pancreatitis, diabetes, liver and neurological disorders. The goal of this study was to identify the prevalence of hyperlipidemia in 55 asymptomatic Miniature Schnauzers, and the frequency of hepatic changes and insulin resistance in hyperlipidemic dogs. Of the 55 dogs in the study, 56.4% had

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Niimi, Manabu, Yajie Chen, Haizhao Yan, Yao Wang, Tomonari Koike, and Jianglin Fan. "Hyperlipidemic Rabbit Models for Anti-Atherosclerotic Drug Development." Applied Sciences 10, no. 23 (2020): 8681. http://dx.doi.org/10.3390/app10238681.

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Hyperlipidemia or dyslipidemia is a major risk factor for atherosclerotic diseases. Experimental animals play an important role in elucidating the molecular mechanisms of the pathophysiology of hyperlipidemia as well as in drug development. Rabbits are one of the most suitable models to study human hyperlipidemia because many features of the lipoprotein metabolism of rabbits are similar to those of humans such as LDL-rich lipoproteins in plasma, apolipoprotein B mRNA editing, and cholesteryl ester transfer protein. Currently, three types of rabbit models are commonly used for studying hyperlip

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Guo, Wei-Ling, Jian-Bin Guo, Bin-Yu Liu, et al. "Ganoderic acid A from Ganoderma lucidum ameliorates lipid metabolism and alters gut microbiota composition in hyperlipidemic mice fed a high-fat diet." Food & Function 11, no. 8 (2020): 6818–33. http://dx.doi.org/10.1039/d0fo00436g.

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Ganoderic acid A from Ganoderma lucidum has the potential to prevent hyperlipidemia, modulates the composition of gut microbiota in hyperlipidemic mice, and significantly attenuates the liver metabolite profile in hyperlipidemic mice.

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Ren, Zhigang, Yali Li, Jiangyun Liu, et al. "Coreopsis Tinctoria Modulates Lipid Metabolism by Decreasing Low-Density Lipoprotein and Improving Gut Microbiota." Cellular Physiology and Biochemistry 48, no. 3 (2018): 1060–74. http://dx.doi.org/10.1159/000491973.

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Background/Aims: The prevalence of hyperlipidemia is increasing rapidly. The role of Coreopsis tinctoria (CT) in amending lipid metabolism in hyperlipidemia patients has not been reported. This study aims to evaluate the role of CT in altering lipid metabolism in hyperlipidemia patients and to explore the possible mechanisms mediated by gut microbiota in hyperlipidemia mice models. Methods: A retrospective analysis in 40 hyperlipidemia patients was conducted, in which 20 patients took fenofibrate and another 20 patients normatively drank water with CT. Hyperlipidemia mice models were also esta

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A.J., Alhassan,, Muhammad I.U., Jarumi, I.K., and Wudil A.M. "Evaluation Of Anti-Hyperlipidemic Potentials Of Aqueous Fruit Pulp Extract Of Adensonia Digitata In Experimental Rats." European Scientific Journal, ESJ 12, no. 12 (2016): 298. http://dx.doi.org/10.19044/esj.2016.v12n12p298.

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Introduction: Hyperlipidemia is a modifiable risk factor of an important killer disease “cardiovascular diseases”, research work exploring anti- hyperlipidemic activity of local plant is timely gesture. Aim: To investigate anti-hyperlipidemic ability of aqueous fruit pulp extract of Adensonia digitata in experimental rats. Methodology: Hyperlipidemia was induced in rats via feeding on high lipid diet (HLD) for 3 weeks. A total of 42 rats used, were divided into seven groups (GI - GVII) of six rats each. GI served as normal control, GII were normal rats administered with only the extract and GI

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Azeez, Refad A. "Presbycusis and hyperlipidemia: Is there any link?" Muthanna Medical Journal 7, no. 2 (2020): 47–57. http://dx.doi.org/10.52113/1/7.2/20.47.

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Age related hearing loss is one of the most common chronic health conditions affecting the elderly people. With aging, risk of Presbycusis and hyperlipidemia increases. Although most studies do reach some sort of agreement, the evidence supporting a relationship between presbycusis and hyperlipidemia remains questionable. The objective of this study is to determine the association between age related hearing loss and hyperlipidemia and assess the severity of hearing loss in hyperlipidemic patients. This cross sectional analytic study was carried out at ENT Out Patient Clinic at Al Sader teachi

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Azeez, Refad Abdul, Ahmed Al Ansary, and BThenoon Yasin. "Presbycusis and hyperlipidemia: Is there any link?" Muthanna Medical Journal 7, no. 2 (2020): 49–57. http://dx.doi.org/10.52113/1/7.2/2020.57.

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"Age related hearing loss is one of the most common chronic health conditions affecting the elderly people. With aging, risk of Presbycusis and hyperlipidemia increases. Although most studies do reach some sort of agreement, the evidence supporting a relationship between presbycusis and hyperlipidemia remains questionable. The objective of this study is to determine the association between age related hearing loss and hyperlipidemia and assess the severity of hearing loss in hyperlipidemic patients. This cross sectional analytic study was carried out at ENT Out Patient Clinic at Al Sader teach

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Eidi, Maryam, та Tayebeh Moradkhani. "Hypolipidemic effect of dill seed (Anethum graveolens L.) essential oil on lipid profile and peroxisome proliferator-activated receptor- γ expression in hyperlipidemic male rats". Veterinarski arhiv 93, № 6 (2023): 731–40. http://dx.doi.org/10.24099/vet.arhiv.2019.

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Herbal medicines have been suggested for the treatment of hyperlipidemic disorders. The hypolipidemic activities of dill essential oil on lipid profile and peroxisome proliferator-activated receptor-γ (PPARγ) expression in adipose tissue were studied in male rats with hyperlipidemia. The effects were studied and compared of dill essential oil and atorvastatin on serum lipid profile and aspartate aminotransferase (AST), alanine aminotransferase (ALT) levels, histopathological damage of liver and PPARγ gene expression in the adipose tissue of male rats with hyperlipidemia. The treatment with dil

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9

Thomas, Licto, and Jagadish Vasudev Kamath. "EVALUATION OF ANTI-HYPERLIPIDEMIC ACTIVITY OF CAPSICUM FRUTESCENS EXTRACT." International Journal of Current Pharmaceutical Research 9, no. 4 (2017): 165. http://dx.doi.org/10.22159/ijcpr.2017v9i4.21289.

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Objective: The objective of the study was to evaluate the in-vivo anti-hyperlipidemic activity of Capsicum frutescens extracts.Methods: The dried fruit powder were extracted with a three liquid phase extraction system. The acetone extract was isolated and the anti-hyperlipidemic activity was evaluated.Results: The anti-hyperlipidemic study was carried out by inducing hyperlipidemia in rats by means of triton. The serum collected was analyzed for total cholesterol, triglyceride, low-density lipoprotein and high-density lipoprotein.Conclusion: The result of the present study revealed that the ac

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Hsu, Tsui-Wen, Pei-Shyuan Lee, Oswald Nfor, et al. "The Interaction between Sex and Hyperlipidemia on Gout Risk Is Modulated by HLA-B Polymorphic Variants in Adult Taiwanese." Genes 10, no. 3 (2019): 246. http://dx.doi.org/10.3390/genes10030246.

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The effects of genetic variants on the interaction between hyperlipidemia and sex have not been investigated among gout patients in Taiwan. Using Taiwan Biobank and the National Health Insurance Research Database (NHIRD), we examined hyperlipidemia, sex, and their relationship with gout among Taiwanese adults with the human leukocyte antigen B (HLA-B) genetic variants. Hyperlipidemia was present in 1437 patients with gout. Sex and hyperlipidemia had significant associations on gout risk, with hyperlipidemia showing a relatively stronger effect. Gout was present in men, with an odds ratio (OR)

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Elsherbiny, Marwa E., May Almukainzi, Eman Amer, and Marwan Emara. "Hyperlipidemia Increases Nalbuphine Brain Accumulation with Multiple Dosing without Affecting Its Analgesic Response—Its Respiratory Depression Potential Should Be Investigated in Future Studies." Pharmaceuticals 17, no. 3 (2024): 282. http://dx.doi.org/10.3390/ph17030282.

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Nalbuphine is associated with a significant risk of respiratory depression. Its central nervous system entry is hindered by P-glycoproteins, and lower P-glycoprotein activity is a risk factor for respiratory depression. We assessed the effect of hyperlipidemia on nalbuphine pharmacokinetics, brain and liver uptake, and analgesic response following single (2.5 mg/kg) and multiple (2.5 mg/kg/day for three days) doses in normolipidemic and hyperlipidemic rats. Trends of reduction and increase in nalbuphine Cmax and Vdss/F were observed, respectively, in hyperlipidemic rats. Negative correlations

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OO, Adetoboye. "The Hypocholesterolemic and Glucose Modulatory Effect of Fibre Enriched Snack in Hyperlipidemic/Hyperglycemic Rat Model Induced by High Cholesterol and High Fructose Diet." Food Science & Nutrition Technology 6, no. 1 (2021): 1–7. http://dx.doi.org/10.23880/fsnt-16000250.

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Dietary interventions have been used in the management of hyperlipidemia. Incorporation of dietary fibre into food products enhances their nutritional value. This study was done to investigate the effect of a fibre enriched snack on the blood glucose level and lipid profile in hyperlipidemia-hyperglycemia - induced wistar albino rats. The rats (n=25) were divided into 5 groups, 1 - fed standard laboratory diet (Control), 2 - fed hyperlipidemic diet and 10% fructose solution, 3 - fed hyperlipidemic diet, 10% fructose solution alongside fibre enriched snack, 4- fed hyperlipidemic diet which was

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Shinde, Rupali, and Asha Arya. "Studies on life style and dietary pattern of seleceted hyper lipidemic subjects of Parbhani city in Maharashtra." INTERNATIONAL JOURNAL OF AGRICULTURAL SCIENCES 19, no. 1 (2023): 81–86. http://dx.doi.org/10.15740/has/ijas/19.1/81-86.

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Hypercholesterolemia or hyperlipidemia or dyslipidaemia, an anothernoncommunicable health problem. Hence, study was conducted with an objective to determine the socioeconomic status, information about dietary intake of hyperlipidemia. Thirty non-insulin dependent hyperlipidemic subjects (men and women) were selected from Parbhani city of Maharashtra state. Information on diet pattern, lifestyle, known risk factors for disease were collected.The information regarding their dietary habits, frequency of consumption of different food groups in a day etc. were collected.The actual food intake of th

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Ren, Qi, Ge Fang, Bin Wang, Xiaowen Zhou та Xiantao Li. "Atractylenolide II-ameliorated hyperlipidemia in mice by regulating AMPK/PPARα/SREBP-1C signaling pathway". Materials Express 9, № 5 (2019): 517–23. http://dx.doi.org/10.1166/mex.2019.1517.

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In this paper, we present our study on the effect of atractylenolide II on hyperlipidemic model mice. After 8 weeks, the blood of these mice was taken to detect four lipids. Pathological changes were detected in the aortas and livers of the mice. Expression of PPARα and SREBP-1C was detected in the liver by western blot. An enzyme-linked immunosorbent assay was used to detect the effects of atractylenolide II on blood lipids in hyperlipidemia mice. Hematoxylin and eosin staining was used to detect pathological changes in the aortas and livers of mice with hyperlipidemia after treatment with at

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15

Williams, Linus Clark, and John Iacomini. "The Th17 lineage in heart transplant rejection: Examining plasticity and pathogenicity." Journal of Immunology 202, no. 1_Supplement (2019): 69.31. http://dx.doi.org/10.4049/jimmunol.202.supp.69.31.

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Abstract Heart transplants are the only treatment for end-stage heart failure. Over 3000 heart transplants were performed in the United States in 2016, making heart transplant the most common cadaveric organ transplant. Long-term survival of heart transplants remains a significant clinical concern, and median survival rates after the first year have not significantly improved in 25 years. We have previously shown that pro-inflammatory co-morbidities such as hyperlipidemia contribute to accelerated IL-17 dependent rejection of the transplanted heart. Hyperlipidemia, an increased level of trigly

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Alkandahri, M. Y., K. Kusumiyati, H. Renggana, et al. "ANTIHYPERLIPIDEMIC ACTIVITY OF EXTRACT AND FRACTIONS OF Castanopsis costata LEAVES ON RATS FED WITH HIGH CHOLESTEROL DIET." RASAYAN Journal of Chemistry 15, no. 04 (2022): 2350–58. http://dx.doi.org/10.31788/rjc.2022.1547015.

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Castanopsis costata is a widely distributed medicinal plant species in North Sumatra, Indonesia. Historically, the Karo people used it to treat various ailments. Therefore, this study aims to determine the extract and fractions of C. costata leaves' anti-hyperlipidemic efficacy. This was evaluated in a rat model of hyperlipidemia induced by a high cholesterol diet. The results showed that the extract and fractions of C. costata leaves had significant anti-hyperlipidemic and anti-atherogenic effects in a rat model of hyperlipidemia induced by a high cholesterol diet. Meanwhile, this is inextric

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Susanti, Gita, Yufri Aldi, Dian Handayani, Friardi Ismed, and Arif Setiawansyah. "Uncovering The Pharmacological Mechanism of Ficus elastica as Anti-hyperlipidemia Candidate: LC-HRMS, Network Pharmacology, In vitro and In vivo Studies." Journal of Multidisciplinary Applied Natural Science 5, no. 1 (2025): 332–51. https://doi.org/10.47352/jmans.2774-3047.249.

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Hyperlipidemia is a major risk factor for cardiovascular diseases. While conventional treatments exist, there is a growing interest in natural remedies with fewer side effects. Ficus elastica has promising medicinal properties, yet its potential as an anti-hyperlipidemic agent remains unexplored. This study aimed to investigate the anti-hyperlipidemic effects of F. elastica using an integrated approach of LC-HRMS-based chemical bioinformatics and in vitro/in vivo experimental validation. The anti-hyperlipidemic potential of F. elastica and its mechanism of action were screened using integrativ

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Bertolami, M. C., A. A. Faludi, Y. Nakamura, et al. "Prevalence of hyperlipidemia in families of hyperlipidemic patients." Atherosclerosis 144 (May 1999): 138. http://dx.doi.org/10.1016/s0021-9150(99)80538-3.

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19

Sun, Haiyang, Shuhuai Meng, Junyu Chen, and Qianbing Wan. "Effects of Hyperlipidemia on Osseointegration of Dental Implants and Its Strategies." Journal of Functional Biomaterials 14, no. 4 (2023): 194. http://dx.doi.org/10.3390/jfb14040194.

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Hyperlipidemia refers to the abnormal increase in plasma lipid level exceeding the normal range. At present, a large number of patients require dental implantation. However, hyperlipidemia affects bone metabolism, promotes bone loss, and inhibits the osseointegration of dental implants through the mutual regulation of adipocytes, osteoblasts, and osteoclasts. This review summarized the effects of hyperlipidemia on dental implants and addressed the potential strategies of dental implants to promote osseointegration in a hyperlipidemic environment and to improve the success rate of dental implan

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Yada, Divya. "CHLOROFORM EXTRICATE OF TRIANTHEMA PORTULACASTRUM, WHOLE PLANT: AN ANTI-HYPERLIPIDEMIC IN ATHEROGENIC DIET INDUCED HYPERLIPIDEMIC RATS." Journal of Medical pharmaceutical and allied sciences 10, no. 4 (2021): 3094–96. http://dx.doi.org/10.22270/jmpas.v10i4.1067.

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Hyperlipidemia is contemplated to be among the considerable risk factor that contributes to the severity as well as incidence of cardiovascular diseases. The Anti hyperlipidemic effect of Chloroform extricate of entire plant Trianthema portulacastrum has been studied in atherogenic diet induced hyperlipidemic rats. Group-I acted as controls (untreated), Group-II acted as atherogenic diet induced controls, standard Hypolipidemic drug (Simvastatin 4mg/kg) used for treating Group-III. The Chloroform Extricate of Trianthema portulacastrum were administered orally at 100mg/kg and 200mg/kg doses for

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Zhao, Mingxia, Kaina Qiao, Lili Zhang, et al. "Research Progress on Anti-Hyperlipidemia Peptides Derived from Foods." Nutrients 17, no. 7 (2025): 1181. https://doi.org/10.3390/nu17071181.

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Hyperlipidemia is a metabolic disorder in which cholesterol (TC) and triglycerides (TGs) in the blood exceed the normal physiological levels. The incidence of the condition has continued to rise in recent years, posing a serious threat to public health. Its clinical treatment mainly relies on drug interventions, such as statins, fibrate, and niacin. Although these drugs have shown some efficacy in the treatment of hyperlipidemia, their adverse effects cannot be ignored. In contrast, naturally derived peptides have gradually become potential candidates for the prevention and treatment of hyperl

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Scheuer, Hartmut, Wilfried Gwinner, Jan Hohbach, et al. "Oxidant stress in hyperlipidemia-induced renal damage." American Journal of Physiology-Renal Physiology 278, no. 1 (2000): F63—F74. http://dx.doi.org/10.1152/ajprenal.2000.278.1.f63.

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Hyperlipoproteinemia can aggravate glomerulosclerosis and chronic tubulointerstitial (ti) damage in kidneys without primary immunologic disease. We evaluated whether the effect of hyperlipidemia on progression of renal damage differed between kidneys without preexisting glomerular disease and kidneys with mesangioproliferative glomerulonephritis and whether the renal actions of hyperlipidemia were dependent on oxidant-antioxidant balance. Hyperlipidemia was induced by high-fat and high-cholesterol diet in uninephrectomized rats. In rats without glomerulonephritis, hyperlipidemia led to a rise

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Bin Jardan, Yousef A., Ali Abdussalam, Ayman O. S. El-Kadi, and Dion R. Brocks. "Dronedarone: the effect of diet-induced obesity on its metabolism and experimental hyperlipidemia on its metabolism and tissue distribution in the rat." Canadian Journal of Physiology and Pharmacology 98, no. 3 (2020): 177–81. http://dx.doi.org/10.1139/cjpp-2019-0125.

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Dronedarone biodistribution in hyperlipidemia and dronedarone metabolism in hyperlipidemia or obesity were assessed. Male Sprague–Dawley rats were given either normal standard chow with water or various high-fat or high-carbohydrate diets for 14 weeks. There was also a nonobese hyperlipidemic group given poloxamer 407 intraperitoneally. Liver and intestinal microsomes were prepared and the metabolic conversion of dronedarone to desbutyldronedarone was followed. A biodistribution study of dronedarone given orally was conducted in hyperlipidemic and control normolipidemic rats. The metabolism of

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Pang, Weiqiao, Di Wang, Zhaohang Zuo, et al. "Kidney Bean Fermented Broth Alleviates Hyperlipidemic by Regulating Serum Metabolites and Gut Microbiota Composition." Nutrients 14, no. 15 (2022): 3202. http://dx.doi.org/10.3390/nu14153202.

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Hyperlipidemia with fat accumulation and weight gain causes metabolic diseases and endangers human body health easily which is accompanied by metabolic abnormalities and intestinal flora disorders. In this study, the kidney bean fermented broth (KBF) was used in rats that were fed a high-fat diet to induce hyperlipidemia in order to subsequently analyse the serum metabolomics and gut microbiota modulatoration. The results show that the contents of the total polyphenols and total flavonoids in the KBF were up three and one times, while energy and carbohydrates decreased. In the HFD-induced hype

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Brocks, Dion R., Hetal R. Chaudhary, Mohamed Ben-Eltriki, Marwa E. Elsherbiny, and Ayman O. S. El-Kadi. "Effects of serum lipoproteins on cyclosporine A cellular uptake and renal toxicity in vitro." Canadian Journal of Physiology and Pharmacology 92, no. 2 (2014): 140–48. http://dx.doi.org/10.1139/cjpp-2013-0250.

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In-vitro studies were performed to shed light on previous findings that showed increased uptake of cyclosporine A in the kidneys and liver of hyperlipidemic rats, and increased signs of kidney toxicity. Hepatocytes were obtained from rats, cultured, and exposed to a diluted serum from hyperlipidemic rats. Some cells were also exposed to lipid-lowering drugs. After washing out the rat serum or lipid-lowering drugs, cells were exposed to cyclosporine A embedded in serum lipoproteins. Pretreatment with hyperlipidemic serum and lipid-lowering drugs was associated with an increased uptake of cyclos

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Hashem, Mohamed A., Noura A. Abd-Allah, Essam A. Mahmoud, Shimaa A. Amer, and Mohamed Alkafafy. "A Preliminary Study on the Effect of Psyllium Husk Ethanolic Extract on Hyperlipidemia, Hyperglycemia, and Oxidative Stress Induced by Triton X-100 Injection in Rats." Biology 10, no. 4 (2021): 335. http://dx.doi.org/10.3390/biology10040335.

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The aim of this study is to assess the efficiency of psyllium husk ethanolic extract (PHEE) on Triton X-100 induced hyperlipidemic rats by studying the changes in hepatic and pancreatic function and histopathology. Forty male albino rats (bodyweight 175–188 g) were grouped randomly into four sets with ten rats. The experimental groups included: (1) control group (CON); (2) Triton X-100 induced hyperlipidemic group—rats were intraperitoneally injected with a single dose of Triton X-100 (100 mg/kg body weight) on the 21st day of Trial onset; (3) PHEE group—PHEE was orally administered (100 mg/kg

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Sangwan, Aditi, Shikha Tewari, Harpreet Singh, Rajinder Kumar Sharma, and Satish Chander Narula. "Effect of hyperlipidemia on response to nonsurgical periodontal therapy: Statin users versus nonusers." European Journal of Dentistry 10, no. 01 (2016): 069–76. http://dx.doi.org/10.4103/1305-7456.175685.

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ABSTRACT Objective: To evaluate the response to nonsurgical periodontal therapy among hyperlipidemic subjects and whether statin use by hyperlipidemic subjects influences the response. Materials and Methods: This study was conducted on 107 chronic periodontitis subjects (35 normolipidemic [NL] controls, 36 hyperlipidemics on nonpharmacological therapy and 36 hyperlipidemics on statins). Periodontal (plaque index, gingival index [GI], probing depth [PD], and clinical attachment level [CAL]) and biochemical (plasma triglyceride [TG], total cholesterol [TC], low-density lipoprotein cholesterol [L

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Kinoshita, Mikio, Shinichi Oikawa, Kyoko Hayasaka, et al. "Age-related Increases in Plasma Phosphatidylcholine Hydroperoxide Concentrations in Control Subjects and Patients with Hyperlipidemia." Clinical Chemistry 46, no. 6 (2000): 822–28. http://dx.doi.org/10.1093/clinchem/46.6.822.

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Abstract Background: The basal lipid peroxide concentration in the plasma of patients with hyperlipidemia may be related to atherosclerosis. Quantitative determination of lipid peroxides in the plasma is an important step in the overall evaluation of the biochemical processes leading to oxidative injury. Unfortunately, the currently available methods for lipid peroxidation lack specificity and sensitivity. Methods: Hyperlipidemic patients (44 males and 50 females), ages 12–82 years (mean ± SE, 53 ± 2.3 years for males, 58 ± 2.0 years for females, and 56 ± 14 years for total cases), and normoli

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Lestari, Dwintha. "Therapeutic potential of Raphanus sativus var. L ethyl acetate fraction in hyperlipidemic and hyperglycemic wistar rats (Rattus norvegicus)." Journal of Medical Pharmaceutical and Allied Sciences 14, no. 3 (2025): 39–44. https://doi.org/10.55522/jmpas.v14i3.6903.

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Cardiovascular diseases (CVD), primarily driven by hyperlipidemia and hyperglycemia, represent a significant global health burden. Effective treatments for these conditions are often inaccessible, particularly in low-income populations, which underscores the importance of exploring alternative therapeutic approaches. This study investigates the anti-hyperlipidemic and anti-hyperglycemic effects of the ethyl acetate fraction from Raphanus sativus var. L. (white radish) in male Wistar rats. The fraction demonstrated significant cholesterol-lowering effects, reducing total serum cholesterol level

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Li, Tao, Guang-ming Yang, Yu Zhu, et al. "Diabetes and hyperlipidemia induce dysfunction of VSMCs: contribution of the metabolic inflammation/miRNA pathway." American Journal of Physiology-Endocrinology and Metabolism 308, no. 4 (2015): E257—E269. http://dx.doi.org/10.1152/ajpendo.00348.2014.

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Vascular endothelial cell injury is considered to be the major factor inducing vascular complications in metabolic diseases and plays an important role in other organ damage. With diabetic and hyperlipidemic rats and cultured VSMCs, the present study was aimed at investigating whether the early damage of VSMCs during metabolic diseases plays a critical role in vascular dysfunction and the underlying mechanisms and would be a promising treatment target. With diabetic and hyperlipidemic rats and cultured VSMCs, the changes and relationships of vascular relaxation and contractile function to the

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MohamedAli, Shahad, Shahad M. Khaleel, Doaa K. Ibrahim, and Sadeel A. Shanshal. "The antihyperlipidemic effects of coenzyme Q10 and gemfibrozil on hyperlipidemic male rats: a comparative study." Review of Clinical Pharmacology and Pharmacokinetics - International Edition 38, no. 2 (2024): 139–45. http://dx.doi.org/10.61873/litc7985.

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Dyslipidemia is considered as the most common risk factor for cardiovascular diseases, cerebrovascular diseases, and fatty liver disease. The available therapy aimed to decrease lipid profile and reduced long-term risk which do require lifelong therapy, hence adverse effects are suggestive. The goal of the present study is to compare the anti¬hyperlipidemic influence and hepatic side effects of CoQ10 and gemfibrozil in the hyperlipidemic male rats model. Twenty-five albino rats were divided into 5 groups: group 1(normal group), group 2 (olive oil group), group 3(hyperlipidemia-induced group) g

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*Wattamwar, P. B., S. A. Landge, Y. U. Kunte, N. B. Kshirsagar, S. L. Kulkarni, and Chidrawar S. G. Dr. "FORMULATION AND EVALUATION OF ANTI-HYPERLIPIDEMIC TABLET." World Journal of Pharmaceutical Science and Research 3, no. 4 (2024): 147–59. https://doi.org/10.5281/zenodo.13151157.

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Hyperlipidemia is one of the leading causes of mortality in developed as well as in developing countries like India. It attributes to the high risk of coronary heart disease and atherosclerosis which is referred as a silent killer. Herbal treatment for hyperlipidemia is inexpensive, readily available locally, and has no negative side effects. Medicinal plants are the "backbone" of traditional medicine so considered as good source of life for all people due to its wealthy therapeutic properties and being 100% natural. Several drugs in Siddha have been found to be beneficial in lowering lipid le

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Susilowati, Retno, and Abdul Malik Setiawan. "Cinnamomum burmannii (Nees & T. Nees) Blume and Eleutherine palmifolia (L.) Merr. extract combination ameliorate lipid profile and heart oxidative stress in hyperlipidemic mice." July-2020 13, no. 7 (2020): 1404–9. http://dx.doi.org/10.14202/vetworld.2020.1404-1409.

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Background and Aim: Hyperlipidemia is an important risk factor for cardiovascular disease. The use of statins has adverse side effects that result in oxidative stress disorders. The objective of this study was to investigate the antihyperlipidemic effect of a combination of Cinnamomum burmannii and Eleutherine palmifolia extract in high-fat diet (HFD)-induced hyperlipidemia mice. Materials and Methods: Mice were divided into eight groups (n=4): Control group or healthy mice (normal), HFD-induced hyperlipidemic mice without any treatment (CE0), HFD-induced hyperlipidemic mice treated with 3.6 m

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Susilowati, Retno, and Abdul Malik Setiawan. "Cinnamomum burmannii (Nees & T. Nees) Blume and Eleutherine palmifolia (L.) Merr. extract combination ameliorate lipid profile and heart oxidative stress in hyperlipidemic mice." July-2020 13, no. 7 (2020): 1404–9. http://dx.doi.org/10.14202/10.14202/vetworld.2020.1404-1409.

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Background and Aim: Hyperlipidemia is an important risk factor for cardiovascular disease. The use of statins has adverse side effects that result in oxidative stress disorders. The objective of this study was to investigate the antihyperlipidemic effect of a combination of Cinnamomum burmannii and Eleutherine palmifolia extract in high-fat diet (HFD)-induced hyperlipidemia mice. Materials and Methods: Mice were divided into eight groups (n=4): Control group or healthy mice (normal), HFD-induced hyperlipidemic mice without any treatment (CE0), HFD-induced hyperlipidemic mice treated with 3.6 m

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Li, Zhi-Zhao, Qiong Huang, Xiao-li Yang, et al. "Cholesterol Metabolic Markers for Differential Evaluation of Patients with Hyperlipidemia and Familial Hypercholesterolemia." Disease Markers 2022 (April 21, 2022): 1–9. http://dx.doi.org/10.1155/2022/2008556.

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The cholesterol metabolism in humans can be indirectly reflected by measuring cholesterol metabolism marker levels. We aimed to investigate the association of cholesterol homeostasis markers on standard lipid profiling components in familial hypercholesteremia and hyperlipidemia patients. A total of 69 hyperlipidemia patients, 25 familial hypercholesteremia (FHC) patients, and 64 healthy controls were enrolled in this study. We performed routine testing of blood lipid water. Gas chromatography was used to determine the changes in the concentration of cholesterol synthesis (squalene, desmostero

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ELBOUNY, Hamza, Rania BENJAMAA, Brahim OUAHZIZI, et al. "Bioactivity of Hertia maroccana and Teucrium malenconianum: antioxidant, antibacterial, and anti-hyperlipidemic effects." Notulae Scientia Biologicae 16, no. 4 (2024): 12095. https://doi.org/10.55779/nsb16412095.

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The main goal of this study was to conduct a phytochemical investigation on the hydro-ethanolic extracts of Hertia maroccana Batt. and Teucrium malenconianum Maire. and to evaluate their antioxidant, antibacterial, and anti-hyperlipidemic activities. The phytochemical study was carried out using chemical screening tests and the antioxidant potential was assessed using in vitro methods. Moreover, agar well diffusion method was used to determine the antimicrobial properties against Staphylococcus aureus and Escherichia coli. In addition, triton-induced acute hyperlipidemia model was used to eval

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Ugare, S., A. D. Tarnalli, and N. A. Khatib. "DOSE DEPENDENT ANTIHYPERLIPIDEMIC ACTIVITY OF ETHANOLIC EXTRACT OF MENTHA ARVENSIS LEAVES IN TRITON AND HIGH CHOLESTEROL DIET INDUCED RATS." INDIAN DRUGS 56, no. 01 (2019): 71–80. http://dx.doi.org/10.53879/id.56.01.11274.

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A study was undertaken to evaluate antihyperlipidemic activity of ethanolic extract of leaves of Mentha arvensis in Triton and high cholesterol diet induced hyperlipidemic male albino Wstar rats. Acute hyperlipidemia was induced by administration of Triton WR-1339 (100 mg / kg i.v.) to the male albino Wstar rats. In chronic models; the animals were fed with high cholesterol diet for a period of 10 days. EEMA leaves at a dose of 200 and 400 mg/kg of body weight were administered at a single dose per day to the hyperlipidemic induced rats for a period of 14 days. In hyperlipidemic rats there is

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Siddiqui, Naveed Ali, and Muhammad Asadullah. "PRIMARY HYPERLIPIDEMIC PATIENTS." Professional Medical Journal 23, no. 05 (2016): 564–70. http://dx.doi.org/10.29309/tpmj/2016.23.05.1584.

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The ratio of cardiovascular disease (CVD) in Pakistan is high as compare to westernworld and is one of the chief reasons of disability around the world. When CVD is diagnosed,following preventive measures should be taken which include regular exercise, proper diet,weight control and lipid reducing drugs to overcome the risk of morbidity or mortality. Primaryhyperlipidemia is common factors for the progression and development of atherosclerosis andcoronary heart disease. This study was designed to evaluate the effects of simvastatin and alliumsativum (garlic) on lipid profile and to compare the

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Pelligra, Tina, Simonetta Citi, Veronica Marchetti, Verena Habermaass, Sara Tinalli, and Caterina Puccinelli. "Evaluation of Liver Parenchyma in Dogs with Hyperlipidemia Using Ultrasound Attenuation Imaging (ATI)." Veterinary Sciences 11, no. 10 (2024): 454. http://dx.doi.org/10.3390/vetsci11100454.

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(1) Background: Ultrasound attenuation imaging (ATI) is an innovative technique that allows for the evaluation of the degree of lipid infiltration of the liver parenchyma in a simple and non-invasive way. The objective of this study was to verify the applicability of the ATI method in the evaluation of hyperlipidemia. (2) Methods: This study included 53 dogs between January 2021 and December 2022, of which 21 were healthy (A) and 32 had hyperlipidemia (B). The dogs of Group B were divided into mild hyperlipidemic (B1; n = 15) and moderate/severe hyperlipidemic (B2; n = 17). Each dog underwent

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Mutmainah, Mutmainah, I. Kadek Bagiana, Ika Puspitaningrum, Lia Kusmita, and Yani Kresnawati. "Potensi Mikroenkapsulasi Ekstrak Daun Stevia Rebaudiana Terhadap Kadar Trigliserida Tikus Putih Jantan Galur Wistar Hiperlipidemia." Journal of Pharmaceutical and Health Research 4, no. 1 (2023): 163–66. http://dx.doi.org/10.47065/jharma.v4i1.3297.

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Coronary heart disease is a cardiovascular disease caused by atherosclerosis. Hyperlipidemia is known as a risk factor for atherosclerosis. The Stevia rebaudiana Bertoni plant is a plant that is efficacious as a hypolipidemic. This study aims to determine the effect of microencapsulated preparations of Stevia rebaudiana Bertoni leaf extract on triglyceride levels in male Wistar rats. One way to improve the formulation is by using the encapsulation process. The encapsulants used are inulin and chitosan. This research was conducted with the aim of making hyperlipidemic rats induced by alloxan at

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Wu, Gui-Rong, Maureen Cheserek, Yong-Hui Shi, Li-Ye Shen, Jing Yu, and Guo-Wei Le. "Elevated Plasma Dityrosine in Patients with Hyperlipidemia Compared to Healthy Individuals." Annals of Nutrition and Metabolism 66, no. 1 (2014): 44–50. http://dx.doi.org/10.1159/000365731.

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Background: Dityrosine, the modification of tyrosine residues, may contribute to metabolic disorders. This study was undertaken to investigate plasma dityrosine concentrations in patients with hyperlipidemia and to examine the correlation between dityrosine and lipid profiles. Methods: Fluorescence spectrophotometry was used to measure dityrosine in the plasma of healthy subjects (n = 203) and dyslipidemic subjects, which included patients with mild hyperlipidemia (n = 246) and hyperlipidemia (n = 179). Advanced oxidation protein products (AOPP) and malondialdehyde (MDA) were also assayed in a

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Geng, Xiong, Weina Tian, Miaomiao Zhuang, Huayan Shang, Ziyi Gong, and Jianrong Li. "Green Radish Polysaccharides Ameliorate Hyperlipidemia in High-Fat-Diet-Induced Mice via Short-Chain Fatty Acids Production and Gut Microbiota Regulation." Foods 13, no. 24 (2024): 4113. https://doi.org/10.3390/foods13244113.

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The objective of this study was to examine the hypolipidemic effect and potential mechanism of action of green radish polysaccharide (GRP) in hyperlipidemic mice. We found that in mice fed a high-fat diet, supplementing with GRP reduced body weight and liver index, significantly improved serum lipid levels and markers of liver damage, and mitigated oxidative stress and inflammation. Mechanistically, in these hyperlipidemic mice, the size of fat cells was reduced by GRP, and the abnormal accumulation of lipid droplets was reduced. We also found that GRP regulates the composition of the intestin

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Duniya Sheneni, Victor, Victor Akagwu Odiba, Ameh Omede, and Favour Moses Idih. "Anti-hyperlipidemic effect of Vitex doniana in poloxamer induced hyperlipidemia." MOJ Biology and Medicine 3, no. 4 (2018): 168–73. http://dx.doi.org/10.15406/mojbm.2018.03.00093.

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To determine the effect of Vitex doniana (leaves stem and root bark) ethanol extracts on lipid profiles of Poloxamer 407 (P-407) induced hyperlipidemic and normal rats. Fifty four mixed sex rats weighing 100-200g were divided into nine groups comprising six animals per group: group given feed and water only, group induced by an intra-peritoneal injection of P-407 every 48hours without treatment, groups induced and treated with atorvastatin, leaves, stem bark, root bark extracts and groups of normal rats treated with leaves, stem bark and root bark extracts without induction. In all the groups,

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Bighetti, Eliete J. B., Alba R. M. Souza-Brito, Eliana C. de Faria, and Helena C. F. Oliveira. "Chronic treatment with bark infusion fromCroton cajucaralowers plasma triglyceride levels in genetic hyperlipidemic mice." Canadian Journal of Physiology and Pharmacology 82, no. 6 (2004): 387–92. http://dx.doi.org/10.1139/y04-040.

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Aqueous infusion and preparations containing dehydrocrotonin (DHC) and essential oil from Croton cajucara bark were tested for plasma lipid-lowering effects in genetically modified hyperlipidemic mice. Two mouse models were tested: 1) primary hypercholesterolemia resulting from the LDL-receptor gene knockout, and 2) combined hyperlipidemia resulting from crosses of LDL-receptor knockout mice with transgenic mice overexpressing apolipo protein (apo) CIII and cholesteryl ester-transfer protein. Mice treated with bark infusion, DHC, essential oil, or placebos for 25 days showed no signals of toxi

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Li, Zhe, Weichao Dong, Yanan Li, et al. "The Metabolites and Mechanism Analysis of Genistin against Hyperlipidemia via the UHPLC-Q-Exactive Orbitrap Mass Spectrometer and Metabolomics." Molecules 28, no. 5 (2023): 2242. http://dx.doi.org/10.3390/molecules28052242.

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Genistin, an isoflavone, has been reported to have multiple activities. However, its improvement of hyperlipidemia is still unclear, and the same is true with regard to its mechanism. In this study, a high-fat diet (HFD) was used to induce a hyperlipidemic rat model. The metabolites of genistin in normal and hyperlipidemic rats were first identified to cause metabolic differences with Ultra-High-Performance Liquid Chromatography Quadrupole Exactive Orbitrap Mass Spectrometry (UHPLC-Q-Exactive Orbitrap MS). The relevant factors were determined via ELISA, and the pathological changes of liver ti

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Kumar, Vishnu, Mohammad Mubin Khan, Ashok Kumar Khanna, et al. "Lipid Lowering Activity ofAnthocephalus indicusRoot in Hyperlipidemic Rats." Evidence-Based Complementary and Alternative Medicine 7, no. 3 (2010): 317–22. http://dx.doi.org/10.1093/ecam/nen001.

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The lipid lowering activity ofAnthocephalus indicus(family Rubiaceae; Hindi name Kadamba) root extract has been studied in triton WR-1339 induced hyperlipidemia in rats. In this model, feeding with root extract (500 mg kg−1b.w.) lowered plasma lipids and reactivated post-heparin lipolytic activity in hyperlipidemic rats. Furthermore, the root extract (50–500 μM) inhibited the generation of superoxide anions and hydroxyl radicals, in both enzymic and non-enzymic systems,in vitro. The results of the present study demonstrated both lipid lowering and antioxidant activities in root extract ofA. in

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Prasetyastuti, Dianandha Septiana Rubi, Abrory Agus Cahya Pramana, and Ahmad Hamim Sadewa. "Correlation between ratio of Nrf2/Keap1 and catalase gene expression in liver of hyperlipidemic rats after administration of 7-hydroxy-2-(4-hydroxy- 3-methoxyphenyl)-chromen-4-one." Journal of the Medical Sciences (Berkala Ilmu Kedokteran) 51, no. 1 (2019): 24. http://dx.doi.org/10.19106/jmedscie/005101201903.

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Hyperlipidemia results in excessive superoxide anion radicals that are the cause ofoxidative stress. Phytochemical compounds can reduce oxidative stress. The aim of thisstudy was to investigate the correlations between ratio of Nrf2/Keap1 and catalase geneexpression in livers of hyperlipidemic rats after administration of 7-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-chromen-4-one. Twenty-four Rattus norvegicus rats, aged 8 weeks andweighing an average of 200 g were randomly divided into 6 groups i.e. Group 1 wasnormal group (N), Group 2 was hyperlipidemic rats (HL), Group 3 was hyperlipidemicrats w

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Uchenna, Agu Francis, Elizabeth Nweke Obioma, Iheukwumere Barry Chinedu, and Dominic Chinedu Ejiofor. "Anti-Hyperlipidemic Effect of Methanol Seed Kernel Extract of Mangifera indica on Wistar Rat Model." Asian Journal of Biochemistry, Genetics and Molecular Biology 13, no. 4 (2023): 11–14. http://dx.doi.org/10.9734/ajbgmb/2023/v13i4299.

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The aim of this study was to evaluate the anti-hyperlipidemic effect of methanol Mangifera indica seed kernel extract on hyperlipidemic Wistar rats. Mango seed kernels were dried at room temperature before being ground into fine powder. 500 g of mango seed kernel powder was soaked in 500 mL of 98 % methanol and shaken intermittently for 72 h, after which the extract was concentrated. Twenty five adult male wistar rats were divided into five groups of five rats each. Group I: was administered 2 ml of distilled water. Groups II-V were induced hyperlipidemia. However, while Group II was not treat

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Yang, Di, Canji Hu, Xiaoyi Deng, et al. "Therapeutic Effect of Chitooligosaccharide Tablets on Lipids in High-Fat Diets Induced Hyperlipidemic Rats." Molecules 24, no. 3 (2019): 514. http://dx.doi.org/10.3390/molecules24030514.

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Chitooligosaccharide is beneficial for inhibiting dyslipidemia and reducing atherosclerotic and hyperlipidemic risk. The purpose of this study was to investigate the cholesterol-regulating effects and potential mechanisms of Chitooligosaccharide tablets (CFTs) in high-fat diet-induced hyperlipidemic rats. The results revealed that CFTs can regulate serum lipid levels in hyperlipidemic rats in a dosage-dependent manner. Synchronously, gene expressions related to cholesterol excretion were upregulated in a dosage-dependent manner, including cholesterol 7α-hydroxylase (CYP7A1), liver X receptor α

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Shahwan, Moyad, Ghassan Shattat, Tariq Al-Qirim, et al. "Synthesis and Pharmacological Evaluation of Novel Substituted and Unsubstituted N-(Benzoylphenyl)-1H-indole-2-carboxamides as Potent Antihypertriglyceridemic Agents." Zeitschrift für Naturforschung C 65, no. 5-6 (2010): 309–16. http://dx.doi.org/10.1515/znc-2010-5-601.

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The N-(benzoylphenyl)-1H-indole-2-carboxamide derivatives 1 - 6 were synthesized, and the lipid-lowering effects of two of these novel compounds were studied using hyperlipidemic rats as an experimental model. Treatment of ethyl-1H-indole-2-carboxylate with aminobenzophenones in the presence of sodium ethoxide and DMF, followed by purifi cation using column chromatography, gave the target compounds in good yields. The tested animals were divided into control, hyperlipidemic, compounds 2-, 3- and bezafibrate-treated groups. At a dose of 15 mg/kg body weight, compounds 2, 3 and bezafibrate signi

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