Journal articles: 'Hyperproteinemia'

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Manning, R. Davis. "Chronic lymph flow responses to hyperproteinemia." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 275, no. 1 (1998): R135—R140. http://dx.doi.org/10.1152/ajpregu.1998.275.1.r135.

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The long-term responses of lymph flow, lymph protein transport, and the permeability-surface area (PS) product to hyperproteinemia have been studied in conscious dogs. Plasma protein concentration (PPC) was increased by daily intravenous infusion of previously collected autologous plasma for 9 days. Lymph flow was determined by collecting lymph chronically from a lymphatic afferent to the popliteal node in the hind leg. Compared with the average value during the normal-PPC period, the following changes occurred during 10 days of high PPC: lymph flow decreased from 12.3 ± 1.1 to 3.8 ± 0.6 μl/min, lymph protein transport decreased from 241 ± 24 to 141 ± 21 μg/min, PS product decreased from 4.7 ± 0.5 to 3.0 ± 0.5 μl/min, PPC increased from 7.1 ± 0.1 to 8.8 ± 0.4 g/dl, lymph protein concentration increased from 1.9 ± 0.1 to 3.8 ± 0.1 g/dl, plasma colloid osmotic pressure increased from 18.6 ± 0.8 to 24.2 ± 2.1 mmHg, and lymph colloid osmotic pressure increased from 4.8 ± 0.2 to 10.4 ± 0.7 mmHg. In conclusion, long-term hyperproteinemia in dogs resulted in chronic decreases in lymph flow, lymph protein transport, and the PS product and chronic increases in lymph protein concentration and lymph colloid osmotic pressure. The marked decrease in lymph flow during hyperproteinemia decreased lymph protein transport and thus contributed to the increase in lymph protein concentration. In addition, the decreases in PS product and lymph protein transport suggest that transcapillary protein flux decreases during hyperproteinemia.

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Wang, Yong-Feng, Guang Wang, Jiang-Lan Li, et al. "Influence of Hyperproteinemia on Insect Innate Immune Function of the Circulatory System in Bombyx mori." Biology 10, no. 2 (2021): 112. http://dx.doi.org/10.3390/biology10020112.

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Metabolic disorders of the circulatory system of animals (e.g., hyperglycemia and hyperlipidemia) can significantly affect immune function; however, since there is currently no reliable animal model for hyperproteinemia, its effects on immunity remain unclear. In this study, we established an animal model for hyperproteinemia in an invertebrate silkworm model, with a controllable plasma protein concentration (PPC) and no primary disease effects. We evaluated the influence of hyperproteinemia on innate immunity. The results showed that high PPC enhanced hemolymph phagocytosis via inducing a rapid increase in granulocytes. Moreover, while oenocytoids increased, the plasmacytes quickly dwindled. High PPC inhibited hemolymph melanization due to decreased phenoloxidase (PO) activity in the hemolymph via inhibiting the expression of the prophenoloxidase-encoding genes, PPO1 and PPO2. High PPC upregulated the gene expression of antimicrobial peptides via differential activation of the Toll and Imd signaling pathways associated with NF-κB signaling, followed by an induction of inconsistent antibacterial activity towards Gram-positive and Gram-negative bacteria in an animal model of high PPC. Therefore, high PPC has multiple significant effects on the innate immune function of the silkworm circulatory system.

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SALVESEN, HARALD A. "Hyperproteinemia in a Case of Nephrosis.1." Acta Medica Scandinavica 65, no. 1 (2009): 152–59. http://dx.doi.org/10.1111/j.0954-6820.1926.tb12264.x.

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Marfaing‐Koka, Anne, Martine Wolf, Catherine Boyer‐Neumann, Dominique Meyer, Michel Odievre, and Philippe Labrune. "Increased Levels of Hemostatic Proteins are Independent of Inflammation in Glycogen Storage Disease Type Ia." Journal of Pediatric Gastroenterology and Nutrition 37, no. 5 (2003): 566–70. http://dx.doi.org/10.1002/j.1536-4801.2003.tb12063.x.

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ABSTRACTObjectivesGlycogen storage disease type Ia (GSD‐Ia), a congenital deficiency of hepatic glucose‐6‐phosphatase activity, is often associated with hyperproteinemia. To document the mechanism of hyperproteinemia, the proteins of the hemostatic system were analyzed according to their site of synthesis: hepatocyte, endothelial cell, or both. The role of inflammation was investigated by the measurement of tumor necrosis factor alpha (TNF‐α) and interleukin‐6 (IL‐6) levels in plasma.MethodsTwenty‐seven patients with GSD‐Ia were evaluated, as were 14 patients with other types of GSD and 30 healthy control subjects. Of the 41 patients with GSD, 15 also had hepatic adenoma (14 patients with GSD‐Ia and 1 with GSD type III).ResultsIn patients with GSD‐Ia, there was a two‐fold increase in all hepatocyte‐synthesized proteins (i.e., factor VII, protein C, C4b binding protein) compared with control subjects and patients with other types of GSD. The proteins with mixed endothelial and hepatocyte origin (i.e., antithrombin and protein S) also were significantly increased but to a lesser extent. In contrast, the mean concentration of von Willebrand factor, which is exclusively synthesized in endothelial cells, was normal, as was the concentration of TNF‐α and IL‐6.ConclusionsThese results suggest that the hyperproteinemia of GSD‐Ia (including hemostatic proteins) is attributable to hepatocyte dysfunction and not related to an inflammatory process.

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Manning, R. Davis. "Dynamics of extracellular fluid volume changes during hyperproteinemia." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 275, no. 6 (1998): R1878—R1884. http://dx.doi.org/10.1152/ajpregu.1998.275.6.r1878.

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The dynamics of fluid volume distribution between the blood and interstitium during hyperproteinemia were studied in 12 anephric, conscious dogs during several states of hydration. After recovery from splenectomy and unilateral nephrectomy, plasma protein concentration was elevated to 8.4–8.7 g/dl by daily intravenous infusion of 330 ml of previously collected autologous plasma for 11 days. The remaining kidney was then removed, and the next day lactated Ringer solution equivalent to 10 or 20% of body weight was infused intravenously. By the end of the 25-h postinfusion period, Ringer infusion had increased circulating protein mass 20.9 ± 9.1% (mean ± SE) in the 10% group ( P< 0.05) and decreased it 10.5 ± 3.3% in the 20% group ( P < 0.05). The average increase in blood volume and arterial pressure during the postinfusion period was 27.4 ± 2.5 and 20.7 ± 3.7%, respectively, in the 10% group but only 17.8 ± 2.4 and 12 ± 1.6% in the 20% group (all changes significant compared with respective control). The relationship between blood volume and sodium space was similar to that found during normoproteinemia, such that elevations in sodium space of 40–50% increased blood volume but greater elevations in sodium space caused no further increases in blood volume. Overhydration during chronic hyperproteinemia causes hypervolemia and hypertension, but, in contrast to those in short-term studies, the increases in blood volume and arterial pressure are not greater than those achieved during normoproteinemia.

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Proverbio, Daniela, Eva Spada, Roberta Perego, and Giada Bagnagatti de Giorgi. "Seizures as a Consequence of Hyperviscosity Syndrome in Two Dogs Naturally Infected with Leishmania infantum." Journal of the American Animal Hospital Association 52, no. 2 (2016): 119–23. http://dx.doi.org/10.5326/jaaha-ms-6240.

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Serum hyperviscosity syndrome (HVS) was documented in two dogs with canine leishmaniasis (CanL) and seizures as the major clinical complaint. In both cases, laboratory abnormalities included mild non-regenerative anemia, thrombocytopenia, hypoalbuminemia, hyperproteinemia with monoclonal gammopathy, and marked serum hyperviscosity. CanL was diagnosed using cytology in one case and indirect immunofluorescence assay and conventional polymerase chain reaction in the second. Specific therapy with meglumine antimoniate and allopurinolc led to short-term remission in both dogs and normalization of serum viscosity. Although dogs rarely develop HVS, it should be suspected if hyperproteinemia and monoclonal gammopathy are present. Since CanL manifests with a variety of clinical presentations, including seizures resulting from HVS-induced central nervous system hypoxia, it should also be considered as a differential diagnosis in animals with seizures as a primary presenting sign.

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Manning, R. D. "Chronic effects of hyperproteinemia on blood volume and lymph protein concentration." American Journal of Physiology-Heart and Circulatory Physiology 262, no. 4 (1992): H937—H941. http://dx.doi.org/10.1152/ajpheart.1992.262.4.h937.

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The long-term effects of hyperproteinemia on blood volume and lymph protein concentration were studied in six conscious dogs over a 17-day period. Plasma protein concentration (PPC) was increased by daily intravenous infusion of approximately 300 ml of previously collected autologous plasma. By day 17 PPC had increased 2.4 g/dl, and plasma colloid osmotic pressure had increased 51%; however, blood volume was not changed. Also, at this time sulfate space, an index of extracellular fluid volume, had increased 12%, prenodal lymph protein concentration had increased from 1.6 to 5.1 g/dl, mean arterial pressure was unchanged, circulating protein mass was increased, and plasma sodium concentration was decreased slightly. In conclusion, the increase in lymph protein concentration during hyperproteinemia may indicate that interstitial fluid protein concentration also increased. This, in turn, would help to prevent any increase in the transcapillary colloid osmotic pressure gradient and thus attenuate any changes in blood volume.

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Manning, R. D. "Renal hemodynamic, fluid volume, and arterial pressure changes during hyperproteinemia." American Journal of Physiology-Renal Physiology 252, no. 3 (1987): F403—F411. http://dx.doi.org/10.1152/ajprenal.1987.252.3.f403.

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The chronic effects of hyperproteinemia on renal hemodynamics, fluid volume, and arterial pressure were determined in six conscious dogs over a 32-day period. Plasma protein concentration was increased by intravenous infusion of approximately 300 ml/day of previously collected autologous plasma, and the responses to changes in sodium intake were studied. By the end of a 9-day period of hyperproteinemia and normal sodium intake, plasma protein concentration had increased 2.2 g/dl, plasma colloid osmotic pressure had increased 7-8 mmHg, mean arterial pressure had increased 12 mmHg, glomerular filtration rate (GFR) had increased 15%, estimated renal plasma flow (ERPF) had increased 51% primarily due to renal vasodilatation, and filtration fraction had decreased 23%. Also, sodium balance was negative, water balance was positive, sodium iothalamate space had increased, plasma sodium concentration had decreased, and the relationship between mean arterial pressure and urinary sodium excretion was shifted to the right along the arterial pressure axis. In conclusion, long-term increases of plasma protein concentration result in a marked increase in ERPF as well as significant increases in GFR, extracellular fluid volume, and arterial pressure.

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Pasquier, G., F. Boukraa, I. Jday, et al. "T293 Retrospective study of hyperproteinemia and hypergammaglobulinemia in French Guiana." Clinica Chimica Acta 530 (May 2022): S208—S209. http://dx.doi.org/10.1016/j.cca.2022.04.119.

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Wang, Yong-Feng, Xue-Dong Chen, Guang Wang, et al. "Influence of hyperproteinemia on reproductive development in an invertebrate model." International Journal of Biological Sciences 15, no. 10 (2019): 2170–81. http://dx.doi.org/10.7150/ijbs.33310.

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Yefremov, A. V., Yu V. Pakhomova, S. V. Michourina, and Ye A. Pakhomov. "Hormonal-metabolic changes in blood serum of rats in acute period after general controlled hyperthermia as a manifestation of hypermetabolism syndrome." Bulletin of Siberian Medicine 5, no. 2 (2006): 84–89. http://dx.doi.org/10.20538/1682-0363-2006-2-84-89.

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Hormonal-metabolic profile of blood serum of rats in 5 hours, on the first and third day after hyperthermia in water medium at the temperature of 45 °С till rectal temperature rose to 43.5 °С was studied. Hypercorticosteronaemia, hyperinsulinemia, hypoglycemia, hypocholesterolemia, hypotriglyceridaemia, hyperproteinemia and increase of protein metabolites level were revealed which was the evidence of hypermetabolism syndrome development during acute period after controlled hyperthermia.

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Nikitina, A. A. "Results of a study of goat blood in the diagnosis of ketosis." Issues of Legal Regulation in Veterinary Medicine, no. 4 (December 29, 2021): 84–86. http://dx.doi.org/10.52419/issn2072-6023.2021.4.84.

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The article presents the results of a screening study in ketosis in goats of the Saanen breed of industrial dairy content. As a result of the work, it was determined that up to 50% of the total livestock suffers from subclinical ketosis. Sick animals have protein metabolism disorders - hyperproteinemia without dysproteinemia, and pigment metabolism disorders - hyperbilirubinemia, the concentration of β-ketones in their blood increases to 0,9 mmol/l.

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White, Stephen D., Rod A. W. Rosychuk, Thomas A. Janik, Phillipe Denerolle, and Patricia Schultheiss. "Plasma cell stomatitis-pharyngitis in cats 40 cases (1973-1991)." Journal of the American Veterinary Medical Association 200, no. 9 (1992): 1377–80. http://dx.doi.org/10.2460/javma.1992.200.09.1377.

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Summary Clinical signs, laboratory findings, and treatment results of 40 cats with the histologic diagnosis of plasma cell stomatitis-pharyngitis are discussed. Median age was 7.1 years, with no discernable sex predilection. Anorexia and difficulty prehending food were the most common clinical signs. Hyperproteinemia with associated hyperglobulinemia was the most common laboratory finding. Of various treatments, administration of corticosteroids or injectable gold (aurothioglucose) proved most effective in controlling the clinical signs.

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Tsanko, Hristov. "BLOOD CHEMISTRY IN DOGS WITH SPLENIC HEMANGIOSARCOMA." TRADITION AND MODERNITY IN VETERINARY MEDICINE 6, no. 1 (2021): 11–14. https://doi.org/10.5281/zenodo.4613430.

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There were 21 blood chemistry examinations conducted on separate dogs with the average age be-ing 9.6±0.63years with pathohistologically proven hemangiosarcoma of the spleen. The results were compared with a control group of 10 clinically healthy dogs. We confirmed higher values of ASAT, ALAT, AP, bilirubin, hyperproteinemia, hypoalbuminemia, hyperglobulinemia, urea and creatinine. In conclusion: hemangiosarcoma of the spleen in dogs is accompanied with data for serious kidney and liver dysfunction.

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Wang, Guang, Yong-Feng Wang, Jiang-Lan Li, et al. "Mechanism of hyperproteinemia-induced blood cell homeostasis imbalance in an animal model." Zoological Research 43, no. 3 (2022): 301–18. http://dx.doi.org/10.24272/j.issn.2095-8137.2021.397.

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Magid, Jonathan H. "Chronic Hyperproteinemia Associated with a Probable Abdominal Abscess in an Appaloosa Stallion." Veterinary Clinics of North America: Equine Practice 22, no. 1 (2006): 53–60. http://dx.doi.org/10.1016/j.cveq.2005.12.006.

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Yamauchi, Mariko, Sahoko Kamejima, Izumi Yamamoto, Ichiro Ohkido, Jun Araya, and Takashi Yokoo. "A case of pulmonary hyalinizing granuloma characterized by pseudohyponatremia due to hyperproteinemia." Respiratory Medicine Case Reports 43 (2023): 101854. http://dx.doi.org/10.1016/j.rmcr.2023.101854.

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Montargil, Stela Maria Argôlo, Fábio Santos Carvalho, Gabriela Mota Sena De Oliveira, Alexandre Dias Munhoz, Renata Santiago Alberto Carlos, and Amauri Arias Wenceslau. "Clinical, Hematological and Biochemical Profiles of Dogs with Leishmania infantum." Acta Scientiae Veterinariae 46, no. 1 (2018): 7. http://dx.doi.org/10.22456/1679-9216.86690.

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Background: Canine Visceral Leishmaniasis is a zoonosis affecting dogs worldwide. Its epidemiological importance is observed in Brazil, wherein the largest number of cases originates in the Northeast Region of the country. The disease is caused by the etiologic agent Leishmania chagasi (= infantum) and transmitted by an invertebrate form of sand fly of the genus Lutzomia. Domestic dogs are one of the main reservoirs. The aim of this study was to use molecular analysis to diagnose dogs naturally infected with Leishmania spp. in the city of Jequié, State of Bahia, Brazil, and to describe the clinical signs, as well as the hematological and biochemical profiles associated with these cases.Materials, Methods & Results: In the present study, 198 dogs underwent physical examination and had blood samples collected for hematological, biochemical and PCR tests for Leishmania infantum. Two primers have been used for the molecular diagnostic technique (PCR): first, the ITS-1 specific to Leishmania species followed by the PCR-RFVL to identify the genus; and second, the primer pair RV1/RV2 specific to the Leishmania infantum species in all the samplesAmong the 198 samples collected, four animals tested positive for the Leishmania infantum via PCR, two of which were symptomatic and two asymptomatic. Among the symptomatic animals, animal one presented with diffuse alopecia, ulcerated lesions on the tip of the ears, ophthalmopathy, onychogryphosis, cachexia, anemia and neutrophilic leukocytosis, and animal two presented with alopecia, pustules, crusting, diffusely-spread erythema, anemia, hyperproteinemia, thrombocytopenia and azotemia. Among the two asymptomatic dogs, one animal had anemia, hyperproteinemia, thrombocytopenia, leukocytosis with neutrophilia, and azotemia; the other animal’s laboratory findings revealed hyperproteinemia and leukocytosis with neutrophilia.Discussion: Although 48 animals presented clinical signs, as well as hematological and biochemical alterations commonly reported in the available literature on Leishmaniasis, only two tested positive by PCR. This implies that a positive diagnosis for this pathology should not be given only based on nonspecific clinical and laboratory data. On the other hand, two animals positive via PCR were asymptomatic, and could act as silent disseminators of the parasite in the region. Since the region is considered endemic for the disease, many dogs may be in the chronic phase, with low parasitemia. The fact that blood with low parasitemia was examined may have influenced the estimate of the ocurrence, as it is common knowledge that in such cases the PCR can deliver a false-negative result due the low amount of DNA for amplification. The ideal tissue should be obtained from the spleen, liver, lymph nodes or via bone marrow puncture. However, it was not possible to collect this kind of tissue due to the need for general anesthesia, which is a limiting factor when the study is conducted with domiciliated animals. Clinical signs found in positive animals involve different systems, due to the multisystemic nature of the disease, and evaluation for differential diagnosis is essential to rule out other pathologies that lead to similar changes, such as systemic lupus erythematosus, ehrlichiosis, and babesiosis, among others. Some of the hematologic changes found in positive animals included: anemia, hyperproteinemia, leukocytosis; all of which are respectively correlated with spinal cord dysfunction, splenic sequestration and hyperglobulinemia due to the intense immune response. We concluded that the PCR enabled the identification of canine visceral leishmaniasis cases in the city of Jequié. However, our study did not identify a relationship between the molecular positivity of dogs to Leishmania infantum and the clinical signs and the hematologic and biochemical analysis of samples from suspected cases.

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Perondi, Francesca, Claudio Brovida, Gianila Ceccherini, Grazia Guidi, and Ilaria Lippi. "Double filtration plasmapheresis in the treatment of hyperproteinemia in dogs affected byLeishmania infantum." Journal of Veterinary Science 19, no. 3 (2018): 472. http://dx.doi.org/10.4142/jvs.2018.19.3.472.

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Steinberger, Beth A., Stephen M. Ford, and Teresa A. Coleman. "Intravenous immunoglobulin therapy results in post-infusional hyperproteinemia, increased serum viscosity, and pseudohyponatremia." American Journal of Hematology 73, no. 2 (2003): 97–100. http://dx.doi.org/10.1002/ajh.10325.

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Freitas, José Cláudio Carneiro de, Diana Célia Sousa Nunes-Pinheiro, Belarmino Eugênio Lopes Neto, et al. "Clinical and laboratory alterations in dogs naturally infected by Leishmania chagasi." Revista da Sociedade Brasileira de Medicina Tropical 45, no. 1 (2012): 24–29. http://dx.doi.org/10.1590/s0037-86822012000100006.

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INTRODUCTION: Canine visceral leishmaniasis (CVL) is a zoonotic disease with different clinical manifestations. Parasitism often occurs in bone marrow, but changes have been observed in peripheral blood and serum biochemical parameters. The aim of this study was to evaluate the hematological and biochemical parameters in dogs naturally infected by Leishmania chagasi. METHODS: Eighty-five adult dogs of both sexes and various weights and ages from the Zoonosis Control Center of Fortaleza (CCZ) were used, selected by immunofluorescence assay (IFA) and considered positive with IFA titers greater than 1:40 and by visualizing amastigotes of Leishmania chagasi in smears obtained by bone marrow aspiration. The dogs (n = 85) were grouped according to clinical signs: negative (CN = 7), subclinical (CS = 10), and clinical (CC = 68). Blood samples were collected for determination of hematological and biochemical serum values. The experimental protocol was approved by the CEUA/UECE. RESULTS: The most frequent clinical signs were cachexia (77.9%), keratitis (61.8%), and lymphadenopathy (55.9%), and 86.8% of the animals showed more than one clinical sign characteristic of CVL. In CC were observed reductions in red blood cells (63%), hematocrit (72%), and hemoglobin (62%), as well as leukocytosis (33%), neutropenia (28%), thrombocytopenia (50%), uremia (45%), hyperproteinemia (53%, p<0.05), hypergammaglobulinemia (62%, p<0.01), and hypoalbuminemia (58%). CONCLUSIONS: Animals with the clinical form of the disease demonstrate hematological and biochemical changes consistent with anemia, uremia, hyperproteinemia, and hyperglobulinemia, which present themselves as strong clinical markers of visceral leishmaniasis associated with the signs previously reported.

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Abutarbush, Sameeh M. "Hematological and serum biochemical findings in clinical cases of cattle naturally infected with lumpy skin disease." Journal of Infection in Developing Countries 9, no. 03 (2015): 283–88. http://dx.doi.org/10.3855/jidc.5038.

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Introduction: Lumpy skin disease (LSD) is an acute viral disease of cattle that is currently emerging in the Middle East region and poses a serious threat to Europe and the rest of the world. The objective of this study was to describe hematological and serum biochemical findings associated with natural clinical infection of LSD in cattle. Methodology: A total of 129 animals clinically infected with LSD were enrolled in the study. Venous blood sample were collected from study animals, and hematological and serum biochemical parameters were measured. Results: Leukocytopenia was found in 8.7%, while leucocytosis was found in 18.2% of affected cattle. Decreased hematocrit concentration was seen in 18.3%. Most affected cattle had reduced mean corpuscular volume (43.7%), mean corpuscular hemoglobin (14.3%), and mean corpuscular hemoglobin concentration (11.5%). All cattle with abnormal platelets count had thrombocytopenia. Hyperfibrinogenemia, hyperproteinemia, and hyperalbuminemia were found in 69%, 59.6%, and 37.2% of affected cattle, respectively. Decreased creatinine concentration was seen in 65.8%. Hyperkalemia and hyperchloremia was found in 9.6% and 10.4% of the affected cattle, respectively. Conclusions: LSD appears to be associated with inflammatory leukogram, anemia, thrombocytopenia, hyperfibrinogenemia, hyperproteinemia, decreased creatinine concentration, hyperchloramia, and hyperkalemia. These are likely due to the associated severe inflammatory process and disease complications such as anorexia and reduced muscle mass. This is the first study that documents hematological and serum biochemical findings associated with LSD infection. Understanding the blood profile picture may give further insight to the pathogenesis of the disease and help in treatment of individual cattle.

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Johnston, Janet K., Thomas J. Divers, Virginia B. Reef, and Helen Acland. "Cholelithiasis in horses: Ten cases (1982–1986)." Journal of the American Veterinary Medical Association 194, no. 3 (1989): 405–9. https://doi.org/10.2460/javma.1989.194.03.405.

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Summary Ten horses with clinical signs consistent with cholelithiasis were evaluated. Fever, icterus, mild intermittent colic, and weight loss were reported. Clinical laboratory abnormalities included leukocytosis, hyperproteinemia, and hyperfibrinogenemia. Gamma glutamyltransferase and liver isoenzyme of lactate dehydrogenase activities also were high. Choleliths were observed via ultrasonography of the liver in 5 of the 8 horses evaluated, and increased echogenicity of the hepatic parenchyma and dilated bile ducts were observed in all horses. Seven horses were treated medically, 5 of which died or were euthanatized. Three horses were treated surgically, of which only 1 survived. Cholelith composition varied, but cholesterol, calcium bilirubinate, and mixed bile pigments were most commonly observed.

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Moriarty, Patrick M., Heather M. Minchew, and Donald C. Oktona. "TREATING LIPOPROTEIN(A)-HYPERPROTEINEMIA AND PROGRESSIVE CARDIOVASCULAR DISEASE WITH LIPID-APHERESIS IN NORTH AMERICA." Journal of the American College of Cardiology 71, no. 11 (2018): A1784. http://dx.doi.org/10.1016/s0735-1097(18)32325-8.

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Abdulazeez, I., S. Biliaminu, U. Hamza, A. Okesina, and A. Omolade. "Prevalence of hyperproteinemia among samples analysed in a tertiary hospital in north central Nigeria." Clinica Chimica Acta 558 (May 2024): 119416. http://dx.doi.org/10.1016/j.cca.2024.119416.

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Nishikawa, Kazuhiro, and Hirokazu Imai. "A Case with Long-term Abnormalities Such as Anemia, Thrombocytosis, Hyperproteinemia, Hypoalbuminemia and Elevated CRP." Nihon Naika Gakkai Zasshi 100, no. 10 (2011): 3093–94. http://dx.doi.org/10.2169/naika.100.3093.

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Nishikawa, Kazuhiro, and Hirokazu Imai. "A Case with Long-term Abnormalities Such as Anemia, Thrombocytosis, Hyperproteinemia, Hypoalbuminemia and Elevated CRP." Nihon Naika Gakkai Zasshi 100, no. 10 (2011): 3106–7. http://dx.doi.org/10.2169/naika.100.3106.

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Bernardini, D., G. Gerardi, B. Contiero, and M. Caldin. "Interference of haemolysis and hyperproteinemia on Sodium, Potassium, and Chloride measurements in canine serum samples." Veterinary Research Communications 33, S1 (2009): 173–76. http://dx.doi.org/10.1007/s11259-009-9280-x.

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Binhazim, Awadh A., Willie L. Chapman, Kenneth S. Latimer, Martha Styles, and Karen Comer. "Canine Leishmaniasis Caused by Leishmania Leishmania Infantum in Two Labrador Retrievers." Journal of Veterinary Diagnostic Investigation 4, no. 3 (1992): 299–305. http://dx.doi.org/10.1177/104063879200400312.

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Canine leishmaniasis, a generally fatal parasitic disease, was diagnosed in 2 dogs with a medical history of foreign travel, lymphadenopathy, emaciation, anorexia, intermittent fever, and cutaneous lesions. Clinically, hyperproteinemia, proteinuria, azotemia, and glomerulopathy were evident. Isolation of Leishmania species was done using Schneider's Drosophila medium. Syrian hamsters were used for infectivity studies. Clear taxonomic identification was done biochemically by isoenzyme analysis and comparison of zymogram banding patterns with 6 World Health Organization reference strains. Based on the geographic origin of affected dogs, clinicopathologic presentation, visceralization with hepatosplenomegaly in hamsters, and isoenzyme analysis, a diagnosis of Leishmania leishmania infantum was made. This study, representing the first taxonomic identification of an isolate from canine leishmaniasis, demonstrates the Zoonotic and epidemiologic implications of this disease.

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Киричко, Б. П., та Т. В. Звенігородська. "Особливості патогенезу та лікування хвороб пародонту в домашніх котів". Вісник Полтавської державної аграрної академії, № 2 (28 червня 2013): 95–97. http://dx.doi.org/10.31210/visnyk2013.02.26.

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Встановлено, що за хвороб пародонту реєструється підвищення показника ШОЕ, рівня глюкози та загального білку, зменшення кількості еритроцитів та лейкоцитів у крові. В ротовій рідині відмічається гіперпротеїнемія та гіперглікемія. Прослідковано залежність активності каталази та рівня малонового діальдегіду під час лікування. Зареєстровано підвищення лізоцимної активності під час лікування в порівнянні з тваринами до лікування. Поєднання консервативного та оперативного методів лікування запальних хвороб пародонту в котів і використання імплантатів «Біомін» дають позитивний ефект. Found that when periodontal disease detected increased ESR, glucose, and gamma-globulin, reducing the number of red blood cells and white blood cells in the blood. In oral fluid celebrated hyperproteinemia and hyperglycemia. The dependence of the level of catalase and malondialdehyde during treatment. The combination of conservative and surgical treatment of inflammatory periodontal diseases in cats and implants "Biomin" make a positive impact.

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Beserra, Lucas, José Augusto Afonso, Carla de Mendonça, et al. "Hematological and biochemical changes in a cow with metastatic cholangiocarcinoma." Brazilian Journal of Veterinary Pathology 15, no. 3 (2022): 173–75. http://dx.doi.org/10.24070/bjvp.1983-0246.v15i3p173-175.

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We describe here hematological and biochemical findings in a cow with metastatic cholangiocarcinoma. On physical examination, apathy with congested mucous membranes, tachycardia and enlarged abdomen; hypoperistalsis in rumen, abomasum and intestines. In hematological examination, icteric plasma with leukocytosis by neutrophilia with regenerative left shift and inversion of the proportion between lymphocytes and segmented neutrophils, and hypofibrinemia. In serum biochemistry: hyperproteinemia, hypoalbuminemia, hyperglobulinemia, low albumin/globulin ratio and high levels of aspartate aminotransferase, gamma-glutamyltransferase. The cow died and in necropsy was observed a severe and diffuse increase in volume predominantly on the hepatic right lobe and moderate increase of volume in mesenteric lymph nodes. Which was diagnosed microscopically as a cholangiocarcinoma, characterized by arrangements in irregular and coalescent ducts. In conclusion, cholangiocarcinoma may cause important hematological and biochemical changes in cattle.

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Chukwudike Anyakudo, Magnus Michael, and Yinka D. Oluwafemi. "Hyperproteinemia Poses Hepatonephrotoxic Effects and Vasculometabolic Risks in Diabetic Rats Fed With a High Protein Diet." Current Developments in Nutrition 9 (May 2025): 106628. https://doi.org/10.1016/j.cdnut.2025.106628.

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Kraevsky, A. Y., V. M. Sokoluk, and O. M. Chekan. "Homeostasis indicators in cows before ostrus synchronization and their influence on the fertilization rate." Ukrainian Journal of Ecology 10, no. 6 (2020): 112–17. http://dx.doi.org/10.15421/2020_268.

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The relationship between cows' homeostasis in the early postpartum period and the effectiveness of fertilization during lactation was analyzed. There were found a decrease in vitamin E to 3.9 ± 0.16 μg/ml, an increase in urea to 6.4 ± 0.24 mmol/l, alkaline phosphatase to 120.7 ± 5.24 U/l, urea nitrogen to 12.3 ± 0.46 mg/ 100 ml and aspartate aminotransferase up to 137.8 ± 10.45 IU/l in cows that were culled or left infertile throughout the lactation period. These data may indicate an overload of the compensatory reactions of the enzymatic and oxidative systems of the liver in cows with defective rumen digestion. There was also persistent hyperproteinemia with compensated oxidative stress due to a decrease in zinc and vitamin E content in cows fertilized 60-120 days compared with those fertilized six months and later after calving.

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Koutinas, AF, ZS Polizopoulou, MN Saridomichelakis, D. Argyriadis, A. Fytianou, and KG Plevraki. "Clinical considerations on canine visceral leishmaniasis in Greece: a retrospective study of 158 cases (1989-1996)." Journal of the American Animal Hospital Association 35, no. 5 (1999): 376–83. http://dx.doi.org/10.5326/15473317-35-5-376.

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The medical records of 158 dogs with visceral leishmaniasis confirmed cytologically and/or serologically were reviewed. Ages of affected dogs varied from nine months to 15 years, with a male-to-female ratio of 1.3. The most common clinical manifestations of the disease were variable cutaneous lesions such as exfoliative dermatitis and skin ulcerations, chronic renal failure, peripheral lymphadenopathy or lymph node hypoplasia, masticatory muscle atrophy (i.e., chronic myositis), ocular lesions (i.e., conjunctivitis, keratoconjunctivitis sicca, blepharitis, and uveitis), and poor body condition. Ascites, nephrotic syndrome, epistaxis, polyarthritis, and ulcerative stomatitis were seen only in a small number of cases. Clinical splenomegaly was not a common finding. The clinicopathological abnormalities were nonregenerative anemia, hyperproteinemia, glomerular proteinuria, and symptomatic or asymptomatic azotemia. In this study, an indirect immunofluorescence assay's diagnostic sensitivity was found to be higher than that of lymph node aspiration cytology.

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Xavier Júnior, F. A. F., P. L. Martins, S. L. Araújo, et al. "Follicular cystitis in a dog: First case report described in Brazil." Arquivo Brasileiro de Medicina Veterinária e Zootecnia 75, no. 2 (2023): 185. http://dx.doi.org/10.1590/1678-4162-12719.

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ABSTRACT A 2-year-old English bulldog presented history of recurrent lower urinary tract disease, refractory to treatment. The Complete Blood Count revealed lymphopenia, hyperproteinemia, and hyperglobulinemia, while urinalysis indicated leukocyturia and bacteriuria. On the abdominal ultrasound, the bladder had a focal wall thickening in its cranial portion, as well as irregular echogenicity and internal margins. A bladder surgical biopsy was performed, indicating the presence of follicular cystitis. Clinical signs disappeared after treatment with a combination of amoxicillin and clavulanic acid, NSAIDs, supplementation with cranberry extract associated with cat's claw (Uncaria tomentosa). Clinical follow-up 12 months after surgery showed remission at all clinical signs. Follicular cystitis in dogs was reported only once worldwide, this case report is the first in Brazil; thus, it may be considered in the differential diagnosis for patients with refractory and recurrent lower urinary tract disease.

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Idrissi, Mariam Hachimi, Khadija Essahli, Soufiane Benaazza, Qamar Zaza, and Hafid Zahid. "Multiple Myeloma in a Young Patient Revealed by Lumbosciatica: A Case Report." Cross Current International Journal of Medical and Biosciences 7, no. 01 (2025): 1–4. https://doi.org/10.36344/ccijmb.2025.v07i01.001.

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Multiple myeloma, a malignant hematologic disorder characterized by excessive monoclonal plasma cell proliferation in the bone marrow, is rare in individuals under 40, comprising less than 2% of cases. This report details a 27-year-old patient with left-sided lumbosciatica and clinical signs of lumbar and radicular syndrome at the S1 level. Imaging revealed multiple osteolytic lesions with perilesional sclerosis and abnormalities in the first sacral foramen. Biological findings included normochromic normocytic anemia, hypercalcemia, elevated sedimentation rate, monoclonal IgG Kappa, free Kappa light chains, hyperproteinemia, and hypoalbuminemia. A bone marrow biopsy confirmed 95% plasma cell infiltration. The patient underwent a VRD regimen and three cycles of D-VRD and is awaiting autologous stem cell transplantation. This case underscores the need to consider multiple myeloma in young patients, as failure to do so could delay critical diagnosis and treatment.

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Evans, Samantha J. M., Matthew P. Truelove, Nicole A. Tebbe, Dixie F. Mollenkopf, M. Judith Radin, and Kelly S. Santangelo. "Formulae to correct sodium concentrations for serum water fraction in cases of hypo‐ and hyperproteinemia in cats." Veterinary Clinical Pathology 49, no. 1 (2020): 100–105. http://dx.doi.org/10.1111/vcp.12833.

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Aquino, L. P. C. T., R. Z. Machado, A. C. Alessi, et al. "Hematological, biochemical and anatomopathological aspects of the experimental infection with Trypanosoma evansi in dogs." Arquivo Brasileiro de Medicina Veterinária e Zootecnia 54, no. 1 (2002): 8–18. http://dx.doi.org/10.1590/s0102-09352002000100002.

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The course of experimental T. evansi infection in four dogs was followed for 82 days and hematological, biochemical and anatomopathological findings were studied. Infected animals showed progressive decrease in red blood cell count and hemoglobin concentration, leading to anemia which persisted from the third week post-infection until the end of the study. Leucopenia and neutropenia were observed between weeks 2 and 5 of the infection. The infected dogs developed hyperproteinemia and a decrease in the albumin:globulin ratio was observed. Aspartate aminotransferase and alamine aminotransferase levels increased significantly in infected dogs in comparison to control dogs. Histological changes observed in all infected animals consisted of lymphoid hyperplasia in spleens and lymph nodes and centrilobular degeneration and periportal mononuclear cell accumulation in the liver. A massive mononuclear cell infiltration of the myocardium was seen in three dogs and a nonsuppurative meningoencephalitis was evidente in two infected animals.

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Massuda, Mayara Beto, Lucas Giordano Ono, Danielle Passarelli, and Deise Carla Almeida Leite Dellova. "Hematological evaluation and parasitological feces examination in shelter dogs." Brazilian Journal of Veterinary Research and Animal Science 61 (December 6, 2024): e218078. https://doi.org/10.11606/issn.1678-4456.bjvras.2024.218078.

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This study aimed to assess the health status of shelter dogs in two cities in the interior of São Paulo State, Brazil, as part of a university extension initiative focused on collective and preventive veterinary care. The project was conducted in two editions. The first was held in 2013 in a shelter in the city of Pirassununga, and the second in 2016 in a shelter in the city of Santa Cruz da Conceição. In total, 24 parasitological examinations of feces from collective kennels and 127 blood counts were conducted. In both editions, a large number of dogs exhibited thrombocytopenia and hyperproteinemia. We also identified cases of anemia and changes in the leukocyte counts, which were consistent with infectious diseases. Most fecal samples tested positive for intestinal parasites. These findings can be partially attributed to the substantial number of dogs in both shelters, which poses challenges for sanitary control.

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Pang, Lu, Ying Xing, Lingsheng Xing, Linzi Miao, Chongwen An, and Haixia Li. "Contradictory Phenomenon Between Serum Separator Tube and Plasma Tube: A Case Report." Laboratory Medicine 52, no. 5 (2021): e125-e128. http://dx.doi.org/10.1093/labmed/lmab003.

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Abstract Separator gels in blood collection tubes are used to separate serum from clotted whole blood or plasma from cells. Here we present a case of a patient with a contradictory phenomenon between the serum separator tube and the plasma tube. The serum separator tube showed mixed serum and separator gel and distinctly less serum. However, the plasma tube showed fewer cells. Laboratory study revealed an IgG level of 78.9 g/L. Serum immunofixation electrophoresis analysis identified the abnormal pattern as a dense IgG band with a corresponding dense light chain band of λ. Bone marrow smear showed 53% proplasmacytes. The patient was diagnosed with multiple myeloma. The marked hyperproteinemia, especially hyperimmunoglobulinemia, may have resulted in the density alteration of serum that was mixed or located above the separator gel. This phenomenon is also seen in patients injected with iodinated radiologic contrast media such as iohexol and in patients on hemodialysis with a concentrated sodium citrate solution.

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AȘTELEAN, Patricia, Eva DIUGAN, Cristian MOLNAR, et al. "The Efficiency of Rectal Fluid Therapy in Moderately Dehydrated Horses." Bulletin of University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca. Veterinary Medicine 75, no. 1 (2018): 73. http://dx.doi.org/10.15835/buasvmcn-vm:004917.

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Dehydration and hydro-electrolytic imbalances are relatively common and life threatening conditions in many animal species including horses. In the present study, we highlighted the efficacy of rectal rehydration in horses, nowadays less commonly used. The study was performed on eight non-pregnant mares (Romanian semigreus and Lipiţan breeds), from Beclean horse stud farm, affected by mild dehydration. The method consists in rectal administration in the form of a high enema of a balanced polyionic solution by using an esophageal tube; the solution contains water, sodium chloride and potassium chloride. Blood samples were collected on EDTA and procoagulant vacutainers, before and after fluid therapy. Laboratory investigations include complete blood count and electrolytes measurement, total protein, albumin, and creatinine. Expectedly, dehydrated animals shown borderline elevated hematocrit associated with mild relative hyperproteinemia and hypernatremia, and elevated uremia levels. In all cases, the parameters were restored in response to therapy, and no side effects were recorded.

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MAMMERI, Adel, Fatima Zohra KAYOUECHE, Loubna DENHADJI, and Abdelmalek BENMAKHLOUF. "Assessment of Blood Metabolites Disorders and Related Pathological Risk Factors in Cows of Constantine Region, Algeria." Bulletin of University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca. Veterinary Medicine 77, no. 2 (2020): 42. http://dx.doi.org/10.15835/buasvmcn-vm:2020.0006.

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The aim of the present study is to evaluate some blood metabolites and to predict the occurence of nutritional imbalances affecting milk production and health status of cows. It included 180 dairy cows of five different breeds reared in five farms of Constantine Governorate. The biochemical analyzes via Technicon RA-X and RA-1000 autoanalyzers focused on: calcium, phosphorus, total proteins, lipids, glucose and creatinine.It results that hyperphosphatemia (> 65 mg/L) was clear in cows of farms 1 and 2 and moderate in those of farm 3; moderate hypocalcemia (< 97mg/L) in cows of farms 1, 2, 3 and 4; moderate hypoproteinemia (< 67 g/L) in farms 2 and 5; moderate hyperproteinemia (> 74.6 g/L) in farms 3 and 4, a clear hypercholesterolemia in whole farms. The significant differences (P< 0.01) via ANOVA test between farms, suggest variability of management methods, feeding practices and health status of cows.

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Marques Andreo, Nathalia, Victor Gabriel Presnal, Gabriel Aguiar Pavilak, Isaac Romani, Tais Harumi de Castro Sasahara, and Leonardo Martins Leal. "Importance of pre-operative complete blood count in elective surgical procedures in dogs and cats - retrospective study." Journal of Dairy, Veterinary & Animal Research 13, no. 1 (2024): 16–18. http://dx.doi.org/10.15406/jdvar.2024.13.00341.

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The complete blood count (CBC) is a test commonly carried out in the preoperative period of surgical procedures in dogs and cats. Blood cells are analyzed for information that reflects the patient's systemic condition, and it is possible to identify some alterations and diseases, even in asymptomatic patients. This study evaluated the preoperative blood count of 119 animals from elective surgeries performed between 2016 and 2021. The most common alteration found was hyperproteinemia with 31.63% (31), followed by thrombocytopenia with 20.41% (20), erythrocytosis 18.37% (18), thrombocytosis 11.22% (11), leukocytosis 8.16% (8) and anemia with 7.14% (7). The least frequent alteration found was leukopenia, with 3.06% (3). In general, 54,17% of the animals had some laboratory alteration, even though they were clinically healthy. Thus, it was possible to confirm the importance of the preoperative blood count in dogs and cats, highlighting the need for this complementary test to minimize surgical risks to the patient.

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Olaifa, Olanrewaju Samuel, Aderonke Rachel Kolawole, Olatunde Babatunde Akanbi, Christiana Ibironke Odita, and Victor Taiwo. "Hematological and Serum Chemistry of Canine Parvoviral Enteritis in Diverse Breeds of Dogs." Media Kedokteran Hewan 36, no. 1 (2025): 21–29. https://doi.org/10.20473/mkh.v36i1.2025.21-29.

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Canine Parvovirus enteritis (CPV-2) is a highly infectious viral disease occurring in puppies resulting in high mortality with a myriad of clinical signs, hematological and biochemical changes during the progression of the disease. This study investigated hematological and biochemical changes in 30 CPV-positive dogs in Ibadan, Nigeria. Severe non-regenerative anemia (35.71%) and leukopenia (22 cases) were prevalent. Thrombocytopenia was severe in 73.33% of cases. Further analysis revealed normocytic hypochromic anemia in 42.86%, microcytic hypochromic anemia in 28.57%, and leukopenia categorized as mild (5), moderate (12), or severe (5). Biochemical changes included hyperproteinemia (26.7%), hyperalbuminemia, hyperglobulinemia, and elevated liver enzymes in some cases. Renal dysfunction was evident in 16.7% of dogs with elevated creatinine. Significant differences (p<0.05) were observed between infected and healthy dogs. These findings underscore the critical impact of CPV on hematological and biochemical profiles, necessitating supportive care and emphasizing the crucial role of vaccination in disease prevention.

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Boyle, Tonya E., Marie K. Holowaychuk, Allison K. Adams, and Steven L. Marks. "Treatment of Three Cats with Hyperviscosity Syndrome and Congestive Heart Failure Using Plasmapheresis." Journal of the American Animal Hospital Association 47, no. 1 (2011): 50–55. http://dx.doi.org/10.5326/jaaha-ms-5635.

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Three cats were evaluated at a veterinary teaching hospital for congestive heart failure (CHF) secondary to hyperviscosity syndrome from plasma cell neoplasia. All cats had severe hyperproteinemia due to hyperglobulinemia. Multiple myeloma or plasma cell neoplasia was diagnosed based on cytopathology and post mortem examination. The cats presented with signs of CHF including acute collapse, tachypnea, increased respiratory effort, and pulmonary crackles. All cats had heart murmurs and echocardiographic signs consistent with hypertrophic cardiomyopathy. An enlarged left atrium was found in all cats and two of three cats also had spontaneous echocardiographic contrast. Plasmapheresis (centrifugal plasma exchange) was performed on all three cats by the removal of whole blood and the infusion of a balanced electrolyte solution while the whole blood was centrifuged and separated. The RBCs were then washed before being readministered to the patient. Plasmapheresis alleviated the clinical signs of CHF (tachypnea) in all three cats. Plasmapheresis should be considered in cases of CHF secondary to hyperviscosity syndrome to rapidly alleviate clinical signs associated with heart failure while diagnosis of the underlying cause is made and appropriate therapy implemented.

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de Almeida Martins, Ana Julia, Vinícius Cruz Silva Sousa, Raiany Borges Duarte, Karla Irigaray Nogueira Borges, Dirceu Guilherme de Souza Ramos, and Ísis Assis Braga. "Epidemiology and hematological analysis of dogs naturally infected by Hepatozoon spp. from central Brazil - retrospective study." Acta Veterinaria Brasilica 18, no. 2 (2024): 151–56. http://dx.doi.org/10.21708/avb.2024.18.2.12047.

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Hepatozoonosis is a hemoparasitosis caused by intracellular protozoa of the genus Hepatozoon, transmitted to dogs and other carnivores by parasitized ticks, such as Rhipicephalus sanguineus and Amblyomma spp. Its prevalence varies by geographic region, favoring tropical and subtropical areas. Hepatozoon spp. infection cause nonspecific clinical manifestation. This longitudinal retrospective study aims to highlight the epidemiological and hematological aspects of dogs naturally infected with Hepatozoon spp. in the municipality of Mineiros, state of Goiás, Brazil, between 2018–2022. This study considered the following information: age, sex, breed, distribution of cases over the years, seasonality, and hematological profile. A total of 272 domestic dogs were found to be parasitized by Hepatozoon spp. using the blood smear technique. Adult dogs were more likely to be affected by hepatozoonosis, with no breed or sexual predisposition. This study showed an exponential increase in cases diagnosed over the years, particularly in autumn and winter (the dry season). Within the study’s evaluation criteria, most dogs had anemia, thrombocytopenia, and hyperproteinemia; however, there were no changes in the total leukocyte count.

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Kawamoto, M., J. J. Kaneko, A. A. Heusner, E. C. Feldman, and I. Koizumi. "Relation of fructosamine to serum protein, albumin, and glucose concentrations in healthy and diabetic dogs." American Journal of Veterinary Research 53, no. 5 (1992): 851–55. http://dx.doi.org/10.2460/ajvr.1992.53.05.851.

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Summary The relation of the glycated serum protein, fructosamine, to serum protein, albumin, and glucose concentrations was examined in healthy dogs, dogs with hypo- or hyperproteinemia, and diabetic dogs. Fructosamine was determined by use of an adaptation of an automated kit method. The reference range for fructosamine in a composite group of control dogs was found to be 1.7 to 3.38 mmol/L (mean ± sd, 2.54 ± 0.42 mmol/L). Fructosamine was not correlated to serum total protein, but was highly correlated to albumin in dogs with hypoalbuminemia. To normalize the data with respect to albumin, it is suggested that the lower limit of the reference range for albumin concentration (2.5 g/dl) be used for adjustment of fructosamine concentration and only in hypoalbuminemic dogs. In 6 hyperglycemic diabetic dogs, fructosamine concentration was well above the reference range. It is concluded that although fructosamine may be a potentially useful guide to assess the average blood glucose concentration over the preceding few days in dogs, further study is required to establish its value as a guide to glucose control in diabetic dogs.

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Bisiuk, V. V., O. Ye Galatiuk, V. L. Behas, Т. О. Romanishina, and A. R. Lakhman. "Hematological parameters and immune response characteristics in canine chlamydiosis." Scientific Messenger of LNU of Veterinary Medicine and Biotechnologies 27, no. 117 (2025): 126–35. https://doi.org/10.32718/nvlvet11718.

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Chlamydiosis is a zoonotic infectious disease caused by bacteria of the genus Chlamydia, characterized by a wide range of clinical manifestations. This study investigates hematological changes and describes certain immunological mechanisms in various clinical forms of the disease. The aim of the research was to analyze hematological parameters and clinical signs in dogs affected by chlamydiosis to determine the relationship between immunological changes and the clinical course of the disease, thereby improving diagnosis and treatment strategies. The study was conducted on 36 dogs diagnosed with respiratory, intestinal, genital, dermatological, and polyarthritis forms of chlamydiosis, with 10 clinically healthy dogs included as a control group. Clinical examinations assessed appetite, behavior, body condition, spatial positioning, tail and ear posture, gaze, coat and skin condition, pupil size, mucous membranes, dental arcade, respiratory movements, body temperature, and heart rate. Hematological parameters were measured using the MicroCC-20 plus analyzer. Biochemical indices were recorded using the HTI BioChem FC-120 (USA) automatic biochemical analyzer. Ultrasonographic examinations were performed with the Logiq P6 PRO system. Fluorographic screening was conducted using the Univet X-ray apparatus. Immunological studies of biological material from dogs with chlamydiosis were carried out at the “Bald” diagnostic laboratory in Kyiv. According to the study results, the most severe course of chlamydiosis was observed in dogs with respiratory syndrome, characterized by hyperthermia, tracheobronchitis, increased pulmonary pattern intensity, and thickening of bronchial walls. Hematological alterations, including leukocytosis, lymphocytosis, and monocytosis, indicate an intense phagocytic immune response of the host organism. The polyarthritis form of chlamydiosis exhibited an immunological pattern resembling an autoimmune response, radiographically confirmed by periostitis in the mid and upper regions of the humerus. Hematologically, segmental neutropenia, lymphocytosis, and monocytosis were recorded. Biochemical alterations, such as hyperproteinemia (P < 0.05), served as markers of systemic inflammatory processes. Elevated alanine aminotransferase activity (P < 0.05) and decreased creatinine levels suggested disruptions in cellular metabolism and joint inflammation. In the intestinal form of chlamydiosis, intestinal barrier dysfunction and systemic intoxication were confirmed by hyperbilirubinemia and hyperproteinemia in the blood serum of affected dogs. The dermatological form showed a significant increase in segmented neutrophils (P < 0.001). The genital form was accompanied by lymphocytosis, bilirubinemia, and increased alanine aminotransferase activity. The findings confirm the correlation between clinical forms of canine chlamydiosis and changes in hematological and biochemical blood parameters, reflecting specific immune responses to the infection. The obtained data may serve as additional, though nonspecific, diagnostic markers aiding in the more precise identification of different chlamydiosis forms in dogs.

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Matoušek, Vojtěch, Ivan Herold, Lenka Holanová, and Martin Balík. "A Rare Case of Severe Metabolic Alkalosis with Unusual Hyperproteinemia Treated with Continuous Renal Replacement Therapy and Regional Citrate Anticoagulation." Case Reports in Nephrology and Dialysis 8, no. 2 (2018): 138–46. http://dx.doi.org/10.1159/000491628.

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A 23-year-old woman was referred to the tertiary centre with acute kidney injury and severe metabolic alkalosis following an accidental ethylene glycol poisoning. The patient had been treated with continuous haemodiafiltration and regional citrate anticoagulation, and a tracheostomy was performed due to pneumonia. Besides severe metabolic alkalosis and hypernatremia, the laboratory tests revealed total protein of 108 g/L on admission to the tertiary centre. The haemodiafiltration with regional citrate anticoagulation continued with parallel correction of the alkalosis and normalisation of the total plasma protein. The tracheostomy was decannulated and the patient was discharged to the district hospital. The case demonstrates the usefulness of regional citrate anticoagulation even in severe metabolic alkalosis which was likely related to the method setting prior to admission and to an overcompensation of the initial severe metabolic acidosis. The unusual hyperproteinaemia might be interpreted with the aid of the Stewart-Fencl model of the acid-base regulation.

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Haegelen, Claire, Laurent Riffaud, Marc Bernard, Beatrice Carsin-Nicol, and Xavier Morandi. "Dural plasmacytoma revealing multiple myeloma." Journal of Neurosurgery 104, no. 4 (2006): 608–10. http://dx.doi.org/10.3171/jns.2006.104.4.608.

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✓The authors describe the case of a 72-year-old woman with dural plasmacytoma revealing an immunoglobulin (Ig) G-kappa multiple myeloma (MM). She presented with headaches and left hemiparesis. Magnetic resonance imaging demonstrated a right frontal extraaxial lesion arising from the dura mater, and biological studies revealed hypercalcemia, hyperproteinemia, and a serum gamma globulin peak. A diagnosis of IgG-kappa MM was based on microscopic examination and immunohistochemical analysis of the dural plasmacytoma as well as on signs of systemic myeloma after surgery. The patient died 3 years after the first symptoms of MM despite systemic chemotherapy and no recurrence of the dural plasmacytoma. Myelomatous involvement of the dura mater is a rare occurrence given that only three cases have been reported to date. Nevertheless, this pathological entity should be differentiated from solitary dural plasmacytoma (SDP) because the prognosis is radically different. Progression seems to be correlated with systemic disease in contrast to the long-term survival associated with SDP. Careful systemic evaluation should be made in such a presentation to rule out MM, which would require different management and has a different prognosis.

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Journal articles on the topic 'Hyperproteinemia'

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