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Journal articles on the topic 'Hypertonic dextrose'

Author: Grafiati

Published: 5 June 2025

Last updated: 2 August 2025

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1

Yi, Tai-Yung, Ta-Wei Wu, and Kuen-Huei Lin. "Hypertonic Dextrose Injections for Osteoarthritis." Rehabilitation Practice and Science 50, no. 2 (2022): 87–94. http://dx.doi.org/10.6315/tjpmr.202212_50(2).0001.

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DeLorenzo, Robert A., and Jeff P. Vista. "Another hazard of hypertonic dextrose." American Journal of Emergency Medicine 12, no. 2 (1994): 262–63. http://dx.doi.org/10.1016/0735-6757(94)90264-x.

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Lin, Che-Li, Ming-Ta Yang, Yu-Hao Lee, Yi-Wen Chen, Timporn Vitoonpong, and Shih-Wei Huang. "Comparison of Clinical and Ultrasound Imaging Outcomes Between Corticosteroid and Hypertonic Dextrose Injections for Chronic Supraspinatus Tendinopathy." Orthopaedic Journal of Sports Medicine 10, no. 11 (2022): 232596712211296. http://dx.doi.org/10.1177/23259671221129603.

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Background: Both corticosteroids and hypertonic dextrose injections are commonly used for chronic supraspinatus tendinopathy. Purpose: To compare the supraspinatus echogenicity and clinical effects of echo-guided hypertonic dextrose versus corticosteroid injection for treating chronic supraspinatus tendinopathy. Study Design: Cohort study; Level of evidence, 3. Methods: The authors performed a secondary data analysis of a previous clinical trial including patients who received normal saline versus hypertonic dextrose injection; patients who received corticosteroid injection were recruited betw

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Shikha, Priyam Pooja, and Kumar Vikas. "Comparing the Efficacy of Varied Dextrose Prolotherapy Concentrations in Treating Osteoarthritis of the Knee: A Double-Blind Randomized Trial." International Journal of Pharmaceutical and Clinical Research 16, no. 2 (2024): 1613–17. https://doi.org/10.5281/zenodo.11085590.

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<strong>Background:</strong> Osteoarthritis (OA) of the knee poses a significant burden due to its associated pain, stiffness, and decreased mobility. Traditional treatments often provide only temporary relief, prompting exploration of alternative therapies like dextrose prolotherapy. However, the optimal concentration of dextrose for maximal efficacy remains uncertain. The objective of the study is to compare the efficacy of varied dextrose prolotherapy concentrations in treating osteoarthritis of the knee, specifically evaluating their impact on pain reduction and functional improvement

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AMENE, PETER C., ROBERT N. SLADEN, THOMAS W. FEELEY, and ROBERT FISHER. "Hypercapnia during total parenteral nutrition with hypertonic dextrose." Critical Care Medicine 15, no. 2 (1987): 171–72. http://dx.doi.org/10.1097/00003246-198702000-00020.

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Vaibhav, Bhadbhade, and B. Jabshetty Anand. "Dextrose Prolotherapy in Osteoarthritis of Knee Joint." International Journal of Pharmaceutical and Clinical Research 15, no. 12 (2023): 1331–36. https://doi.org/10.5281/zenodo.11201517.

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<strong>Introduction: </strong>Osteoarthritis (OA) of knee joint is a chronic, progressive, and joint disabling disease, often resulting in a poor quality of life. Knee osteoarthritis often results in joint pain, stiffness, and decreased function. The Agency for Healthcare Research and Quality has called for the development of new therapies to prevent and treat knee osteoarthritis. These include hypertonic dextrose prolotherapy, ozone, botulinum toxin, platelet-rich plasma, and hyaluronic acid. <strong>Materials and Methods: </strong>This prospective study enrolled patients from

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Shashi, Preeti, Gursimran Kochhar, and Bo Shen. "Endoscopic therapy of colorectal anastomotic hematoma with hypertonic dextrose." Gastroenterology Report 7, no. 6 (2018): 455–58. http://dx.doi.org/10.1093/gastro/goy026.

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Abstract Anastomotic dehiscence and leak are dreaded complications after a colorectal resection and can often present with rectal bleeding and pelvic abscess or sepsis. Although most cases of bleeding after gastrointestinal anastomoses are minor and self-limited, major bleeding, as defined by hemodynamic instability or the need for blood transfusions, poses a significant challenge for management. Here we report a case in which a patient presenting with profuse rectal bleeding and pelvic hematoma secondary to a colorectal anastomotic leak was treated endoscopically with 50% dextrose spray then

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Zivanna, Avissia, and Eka Poerwanto. "The effect of hypertonic dextrose prolotherapy on knee osteoarthritis outpatients in Dr. Ramelan Navy Hospital Surabaya: case series." Intisari Sains Medis 14, no. 1 (2023): 315–19. http://dx.doi.org/10.15562/ism.v14i1.1456.

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Background: The high use and pressure on the knee cause osteoarthritis to occur frequently. Prolotherapy is a non-surgical injection therapy used to treat chronic pain in musculoskeletal conditions, including knee OA. This solution can create local irritation, inflammation, and tissue regeneration, thereby increasing the strength of damaged ligaments, tendons, and intra-articular structures. Therefore, the aim of this research is to assess the changes in VAS and WOMAC scores, as well as plain radiographs of knee OA patients after hypertonic dextrose prolotherapy. Methods: This experimental cas

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Singh, Neeraj, Anil K. Gupta, Dileep Kumar, Sudhir Mishra, Ganesh Yadav, and Shreya Singh. "The comparative effects of injecting intra-articular platelet-rich plasma and hypertonic dextrose prolotherapy in osteoarthritis knee - A randomized control trial." Journal of Family Medicine and Primary Care 14, no. 6 (2025): 2180–86. https://doi.org/10.4103/jfmpc.jfmpc_1206_24.

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ABSTRACT Introduction: Knee osteoarthritis is an age-dependent disease caused by degenerative and healing processes in subchondral tissue of articular and bone cartilage, resulting in changes of its biochemical properties that eventually causes pain, stiffness, and decreased articular function. Therefore, this study aims to compare the effectiveness of platlet-rich plasma (PRP) therapy and 25% hypertonic dextrose (Dextrose) prolotherapy in patients with knee osteoarthritis. Material and Methods: Single-blind randomized control trial was conducted for 18 months. Patients satisfying the inclusio

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Tzamaloukas, Antonios H. "Avoiding the Use of Hypertonic Dextrose Dialysate In Peritoneal Dialysis." Seminars in Dialysis 13, no. 3 (2001): 156–59. http://dx.doi.org/10.1046/j.1525-139x.2000.00041.x.

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11

Rabago, David, Marlon Mundt, Aleksandra Zgierska, and Jessica Grettie. "Hypertonic dextrose injection (prolotherapy) for knee osteoarthritis: Long term outcomes." Complementary Therapies in Medicine 23, no. 3 (2015): 388–95. http://dx.doi.org/10.1016/j.ctim.2015.04.003.

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Yoshii, Yuichi, Chunfeng Zhao, James D. Schmelzer, Phillip A. Low, Kai-Nan An, and Peter C. Amadio. "Effects of hypertonic dextrose injections in the rabbit carpal tunnel." Journal of Orthopaedic Research 29, no. 7 (2011): 1022–27. http://dx.doi.org/10.1002/jor.21297.

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Hassan, Rao Erbaz, Yaseen Ahmad, Hamza Haroon, Arif Ullah Khan, and Mahnoor Abbasi. "Hypertonic Dextrose Prolotherapy for Knee Osteoarthritis: A Comprehensive Review of Mechanism, Techniques, Limitations, and Side Effects." Journal of Islamabad Medical & Dental College 13, no. 2 (2024): 375–80. http://dx.doi.org/10.35787/jimdc.v13i2.1245.

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This review delves into the potential of hypertonic dextrose prolotherapy (HDP) as a treatment for knee osteoarthritis (KOA), a prevalent condition, that significantly impacts individuals' quality of life, particularly affecting older adults. HDP involves injecting a hypertonic dextrose solution into or around the affected joint, inducing inflammation and subsequent tissue healing. This review examines various aspects of HDP, including its mechanism of action, comparative effectiveness with other therapies, dosage, and safety considerations as well as HDP's cost-effectiveness, safety profile,

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Duman, S., S. ŞEn, E. Y. SÖZmen, and D. G. Oreopoulos. "Atorvastatin Improves Peritoneal Sclerosis Induced by Hypertonic PD Solution in Rats." International Journal of Artificial Organs 28, no. 2 (2005): 170–76. http://dx.doi.org/10.1177/039139880502800214.

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Background Peritoneal sclerosis is a complication of peritoneal dialysis and results in ultrafiltration failure. It is related to chronic peritoneal injury due to dialysis solution content and recurrent peritonitis. Statins have anti-inflammatory properties which may be of value in modulating responses to injury. We evaluated the capacity of atorvastatin to modify peritoneal alterations secondary to hypertonic glucose. Methods Thirty-two non-uremic rats were divided into three groups: group I (Sham) rats received no treatment (n=11), group II received hypertonic (3.86%, 10 ml/day) PD solution

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Ke, Q.-H., T.-B. Liang, J. Yu, and S.-S. Zheng. "A Study of the Pathogenesis and Prevention of Central Pontine Myelinolysis in a Rat Model." Journal of International Medical Research 34, no. 3 (2006): 264–71. http://dx.doi.org/10.1177/147323000603400305.

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The development of central pontine myelinolysis was studied in rats. Severe hyponatraemia was induced using vasopressin tannate and 2.5% dextrose in water and then rapidly corrected with hypertonic saline alone, hypertonic saline and dexamethasone simultaneously, or hypertonic saline plus dexamethasone 24 h later. The permeability of the blood-brain barrier was evaluated using the extravasation of Evans blue dye and the expression of inducible nitric oxide synthase (iNOS) in the brain was examined using Western blot analysis. Histological sections were examined for demyelinating lesions. In ra

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Sethi, Anshul, Muzaffar Mushtaq, Pankaj Dagar, Abdul Basit, and Owais A. Qureshi. "Efficacy of hypertonic dextrose (prolotherapy) in early knee osteoarthritis: a short term outcome." International Journal of Research in Orthopaedics 10, no. 6 (2024): 1270–77. http://dx.doi.org/10.18203/issn.2455-4510.intjresorthop20243122.

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Background: Knee osteoarthritis (OA) is a prevalent, painful, and progressive condition significantly affecting patients' quality of life and imposing a social and economic burden. Traditionally managed through symptom relief and joint function improvement, research is increasingly focusing on disease-modifying treatments. Dextrose prolotherapy, a low-cost alternative involving the injection of a hypertonic solution, has shown promise despite limited acceptance in current guidelines. Methods: This prospective cohort study, approved by the Institutional Ethical Board of Jamia Hamdard University

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Duman, Soner, Ali Ihsan Günal, Sait Sen, et al. "Does Enalapril Prevent Peritoneal Fibrosis Induced by Hypertonic (3.86%) Peritoneal Dialysis Solution?" Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis 21, no. 2 (2001): 219–25. http://dx.doi.org/10.1177/089686080102100221.

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Objective Peritoneal fibrosis (PF) is one of the most serious causes of failure in continuous ambulatory peritoneal dialysis (PD). Although the underlying mechanism responsible for the genesis of PF is still unknown, transforming growth factor p (TGFβ1) has been shown to be associated with PF. Angiotensin converting enzyme inhibitors have been shown to prevent the stimulating effect of growth factors. The aim of the present study was to investigate the effect of enalapril on peritoneal function and morphology in a rat model of experimental PF. Methods Twenty-one albino Wistar rats were divided

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付, 奕翎. "Observation and Analysis of Hypertonic Dextrose in the Treatment of Knee Osteoarthritis." Advances in Clinical Medicine 11, no. 11 (2021): 5207–12. http://dx.doi.org/10.12677/acm.2021.1111769.

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Lui, Kei, Udayabhanu Thungappa, Arun Nair, and Elizabeth John. "Treatment with hypertonic dextrose and insulin in severe hyperkalaemia of immature infants." Acta Paediatrica 81, no. 3 (1992): 213–16. http://dx.doi.org/10.1111/j.1651-2227.1992.tb12206.x.

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Topol, Gastón Andrés, Leandro Ariel Podesta, Kenneth Dean Reeves, et al. "Chondrogenic Effect of Intra-articular Hypertonic-Dextrose (Prolotherapy) in Severe Knee Osteoarthritis." PM&R 8, no. 11 (2016): 1072–82. http://dx.doi.org/10.1016/j.pmrj.2016.03.008.

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21

Flanigan, Michael J., Lisa Pillsbury, George Sadewasser, and Victoria S. Lim. "Regional hemodialysis anticoagulation: hypertonic tri-sodium citrate or anticoagulant citrate dextrose-A." American Journal of Kidney Diseases 27, no. 4 (1996): 519–24. http://dx.doi.org/10.1016/s0272-6386(96)90162-6.

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Akgül, Öncü, and Nilgün Çerikçioğlu. "Hypertonic Sabouraud Dextrose Agar as a Substrate for Differentiation of Candida dubliniensis." Mycopathologia 167, no. 6 (2009): 357–59. http://dx.doi.org/10.1007/s11046-009-9187-7.

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23

Rabago, David, Ken S. Lee, Michael Ryan, et al. "Hypertonic Dextrose and Morrhuate Sodium Injections (Prolotherapy) for Lateral Epicondylosis (Tennis Elbow)." American Journal of Physical Medicine & Rehabilitation 92, no. 7 (2013): 587–96. http://dx.doi.org/10.1097/phm.0b013e31827d695f.

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Khan, Md Salman, Vikas Dwivedi, Sachin Upadhyay, Pradeep Patel, and Jagmohan Singh Dhakar. "To evaluate the Clinical Efficacy of the Cocktail and 15% hypertonic Dextrose Solution Injection for Plantar Fasciitis." SSR Institute of International Journal of Life Sciences 10, no. 6 (2024): 6569–75. https://doi.org/10.21276/ssr-iijls.2024.10.6.31.

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Chalmeh, A., A. Mirzaei, M. Pourjafar, et al. "Glucose related endocrine and metabolic responses following bolus intravenous hypertonic dextrose administration in Iranian fat-tailed ewes at different pre and post parturition periods." BULGARIAN JOURNAL OF VETERINARY MEDICINE 23, no. 1 (2020): 44–59. http://dx.doi.org/10.15547/bjvm.2160.

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Providing glucose as primary metabolic fuel for maintenance, foetal growth and milk production may be considered necessary for protection against negative energy balance and metabolic disorders. Five adult Ghezel ewes were selected 4 weeks before their parturition and followed at 2 weeks before, 2 and 4 weeks and 2, 3 and 4 months after parturition. Dextrose 50% was administered at 500 mg/kg, 10 mL/kg/hour, and blood samples were collected from all ewes prior to and 1, 2, 3 and 4 hours after 50% dextrose infusion. Serum levels of glucose, beta-hydroxybutyric acid, non-esterified fatty acids, c

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Tri Cahyadi, N. Indra, and Paul Steven. "Hypertonic dextrose compare with other substances for knee osteoarthritis: a meta-analysis of randomized control trial." International Surgery Journal 12, no. 1 (2024): 72–79. https://doi.org/10.18203/2349-2902.isj20243988.

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Background: Globally, osteoarthritis (OA) highly prevalent in the elderly more than 80% of those over 55 years old. At least 151 million people worldwide are afflicted. The knees, hips and spine are the joint areas that are most frequently affected. For the treatment of knee OA, intra-articular injection like stem cells, platelet rich plasma (PRP), and hypertonic dextrose (HD) the most used prolotherapy fluid is HD. It is widely accessible, reasonably inexpensive priced and reportedly safe. The aim of this meta-analysis is to thoroughly assess and compare the results of intra articular dextros

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Varma, H. S., Sachin Upadhyay, and A. Vidyarthi. "THERAPEUTIC EFFECT OF COCKTAIL VS PROLOTHERAPY INJECTION IN CHRONIC PLANTAR FASCIITIS, A PROSPECTIVE CONTROLLED RANDOMIZED CLINICAL STUDY." International Journal of Advanced Research 10, no. 10 (2022): 1008–16. http://dx.doi.org/10.21474/ijar01/15575.

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Introduction:- Plantar fasciitis is the most common cause of heel pain. It is a self-limiting condition. If causative factors are not addressed properly, it becomes chronic plantar fasciitis. Objectives:- The study aimed to evaluate the efficacy of 15 % hypertonic dextrose (treatment group) in the treatment of chronic plantar fasciitis through comparison with a cocktail group (control group). Design:- In this prospective controlled, randomized clinical study at N.S.C.B. Medical College Jabalpur, from 1 January 2020 to 31 September 2021. The statistical test used in this study isthe chi-square

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Rowe, Carl E., Thomas T. Fukuyama, and James T. Martinoff. "Growth of Microorganisms in Total Nutrient Admixtures." Drug Intelligence & Clinical Pharmacy 21, no. 7-8 (1987): 633–38. http://dx.doi.org/10.1177/1060028087021007-814.

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It has been reported that intravenous fat emulsions, because of their isotonicity and neutral pH, support microbial growth, but traditional parenteral nutrition solutions, being hypertonic and more acidic, are not as supportive. To date, few studies have documented microbial growth in total nutrient admixtures (TNA) containing dextrose, amino acids, fat, electrolytes, vitamins, and trace elements. This study was undertaken to analyze the growth of Staphylococcus aureus, Candida albicans and four gram-negative enteric bacilli in three different nutrient admixtures, with and without the inclusio

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Turosz, Natalia, Kamila Chęcińska, Maciej Chęciński, et al. "Temporomandibular Joint Injections and Lavage: An Overview of Reviews." Journal of Clinical Medicine 13, no. 10 (2024): 2855. http://dx.doi.org/10.3390/jcm13102855.

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Objectives: This overview was conducted following the Preferred Reporting Items for Overviews of Reviews guidelines and aimed to collect and compare the results of systematic reviews on temporomandibular joint injection treatment. Methods: Systematic reviews of randomized clinical trials on temporomandibular disorders treated with lavage or intra-articular administrations were qualified for syntheses. The final searches were conducted on 27 February 2024, without time frame restrictions. Results: Of the 232 identified records, 42 systematic reviews were selected. The most evidence-based conclu

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YILDIZ, Yavuz, Ali APAYDIN, Mehmet SEVEN, and Aydan ORSCELIK. "The Effects of Prolotherapy (Hypertonic Dextrose) in Recreational Athletes with Patellofemoral Pain Syndrome." Journal of Experimental and Integrative Medicine 6, no. 2 (2016): 53. http://dx.doi.org/10.5455/jeim.260616.or.152.

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Rabago, David, Bobby B. Nourani, Marlon Mundt, Aleksandra Zgierska, and Jessica Grettie. "Hypertonic dextrose injection (prolotherapy) to multiple tissues for knee osteoarthritis: Long term outcomes." Journal of Bodywork and Movement Therapies 20, no. 1 (2016): 153. http://dx.doi.org/10.1016/j.jbmt.2015.07.032.

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Maulahela, Hasan, Amanda Pitarini Utari, Rabbinu Rangga Pribadi, Virly Nanda Muzelina, and Saskia Aziza Nursyirwan. "Hypertonic dextrose spray as topical endoscopic hemostasis for non-variceal upper gastrointestinal bleeding." International Journal of Gastrointestinal Intervention 12, no. 2 (2023): 93–98. http://dx.doi.org/10.18528/ijgii220036.

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Günal, Ali Ihsan, Hüseyin Celiker, Nusret Akpolat, Bilal Üstündag, Soner Duman, and Fehmi Akcicek. "By Reducing Production of Vascular Endothelial Growth Factor Octreotide Improves the Peritoneal Vascular Alterations Induced by Hypertonic Peritoneal Dialysis Solution." Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis 22, no. 3 (2002): 301–6. http://dx.doi.org/10.1177/089686080202200302.

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Objective Chronic peritoneal dialysis (PD) may eventually result in vascular alterations of varying degree, which lead to progressive reduction in dialytic efficacy. Although the pathogenesis has not been elucidated yet, vascular endothelial growth factor (VEGF) has been proposed to play a central role in the process leading to vascular alterations. Design Rats were allocated to three groups: no treatment, intraperitoneal introduction of hypertonic PD solution alone, and intraperitoneal introduction of hypertonic PD solution plus octreotide. After 4 weeks, a 1-hour peritoneal equilibration tes

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Preeti, Soni, Kumar Meena Rajesh, and Kumar Meena Mahesh. "The Prolonged Impact of Prolotherapy on Joint Well-Being in Osteoarthritis Individuals." International Journal of Pharmaceutical and Clinical Research 16, no. 5 (2024): 25–28. https://doi.org/10.5281/zenodo.11395309.

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Over three years, this study evaluates the long-term efficacy and safety of prolotherapy using hypertonic dextrose in treating knee osteoarthritis. This observational study included 200 individuals with chronic knee pain characteristic of osteoarthritis. Participants received dextrose injections under ultrasound guidance, with the process meticulously detailed to ensure consistency. Annual X-rays and initial and final MRIs were performed to monitor changes in joint structure. Pain and functionality were assessed using the Visual Analogue Scale (VAS) and the Western Ontario and McMaster Univers

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Wilcox, C. S., and W. S. Peart. "Release of renin and angiotensin II into plasma and lymph during hyperchloremia." American Journal of Physiology-Renal Physiology 253, no. 4 (1987): F734—F741. http://dx.doi.org/10.1152/ajprenal.1987.253.4.f734.

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Renal vascular resistance (RVR) was related to intrarenal release of renin (RR) and angiotensin II (ANG II) during increases in plasma osmolality (Posmol) or chloride (PCl). Intrarenal infusions of 1.232 M solutions given to in situ kidneys increased Posmol by 7-18%. Hypertonic dextrose (n = 8) reduced RVR (P less than 0.005) but increased RR into plasma (P less than 0.01) and increased lymph renin (LR) (P less than 0.05). The response to hypertonic Na acetate (n = 5) was similar, but hypertonic NaCl (n = 9) increased RVR (P less than 0.02) without changing RR. During infusion of arachidonic a

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Kandhikonda, Sravika, Sai Charan Golusu, Vaibhavi K, et al. "Clinical Management of Paraphimosis in a Mongrel Dog: A Case Report." UTTAR PRADESH JOURNAL OF ZOOLOGY 45, no. 22 (2024): 104–7. https://doi.org/10.56557/upjoz/2024/v45i224663.

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The present case deals with clinical management of paraphimosis in 1 year old mongrel dog Presented to Teaching veterinary Clinical Complex. After thorough clinical examination the protruded penis was cleaned and antiseptic dressing was done. Then edema was reduced by applying Hypertonic solution D25 (25 percent dextrose solution) and ice packs. Once the swelling had sufficiently decreased, the area was cleaned again Lignocaine gel was applied topically for pain management and lubrication, allowing for a gentle repositioning of the penis into the preputial sheath Prognosis was good. No further

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Sit, Regina Wing Shan, Ricky Wing Keung Wu, David Rabago, et al. "Efficacy of Intra-Articular Hypertonic Dextrose (Prolotherapy) for Knee Osteoarthritis: A Randomized Controlled Trial." Annals of Family Medicine 18, no. 3 (2020): 235–42. http://dx.doi.org/10.1370/afm.2520.

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Hoffman, Jerome R., David L. Schriger, Scott R. Votey, and John S. Luo. "The empiric use of hypertonic dextrose in patients with altered mental status: A reappraisal." Annals of Emergency Medicine 21, no. 1 (1992): 20–24. http://dx.doi.org/10.1016/s0196-0644(05)82231-0.

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Duman, S., S. ŞEn, C. Duman, and D. G. Oreopoulos. "Effect of Valsartan versus Lisinopril on Peritoneal Sclerosis in Rats." International Journal of Artificial Organs 28, no. 2 (2005): 156–63. http://dx.doi.org/10.1177/039139880502800212.

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Background Peritoneal sclerosis (PS) is one of the most serious causes of failure in long-term peritoneal dialysis. Angiotensin II is known to promote fibrosis and inflammation in various tissues. We previously showed that ACE inhibitors (ACEIs) have beneficial effects on hypertonic PD solutions (3.86% PD) induced peritoneal alterations. The aim of this study is to compare the effects of an ACEI and a receptor blocker on peritoneal alterations induced by hypertonic PD solutions in rats. Methods Forty-three non-uremic rats were divided into four groups: group I (Sham) rats received no treatment

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Waluyo, Yose, Agussalim Bukhari, Endy Adnan, et al. "Association between cartilage biomarker level and functional outcome in knee osteoarthritis patients receiving dextrose prolotherapy: a cross-sectional study." Bali Medical Journal 11, no. 3 (2022): 1151–56. http://dx.doi.org/10.15562/bmj.v11i3.3395.

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Background: Knee osteoarthritis (KOA) is a degenerative joint disease with relatively high prevalence globally and is one of the leading causes of disability in the elderly population. Dextrose prolotherapy (DPT) has been proven effective in improving functional outcomes in knee osteoarthritis. The effect of hypertonic dextrose on cartilage biomarkers has not been evaluated. Purpose: To evaluate the association between a cartilage biomarker and changes in clinical outcomes among patients with KOA who received dextrose prolotherapy (DPT). Patients and methods: This study was conducted with a cr

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POERWANTO, EKA, HENDRATA ERRY ANDISARI2, Rr. MUTIARA DEVANIA SAMARA QALBA, and RONALD PRATAMA ADIWINOTO. "Perbandingan Efektivitas Platelet Rich Plasma VS Hypertonic Dextrose Prolotherapy terhadap Perbaikan Klinis Pasien Osteoartritis Genu." Hang Tuah Medical Journal 22, no. 1 (2024): 77–96. https://doi.org/10.30649/htmj.v22i1.639.

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Latar belakang: Osteoartritis lutut (OA) terutama menyerang orang yang berusia lanjut, menyebabkan degenerasi sendi dan penurunan mobilitas. Meskipun pengobatan saat ini meliputi obat-obatan dan pembedahan, terapi regeneratif seperti Platelet Rich Plasma (PRP) dan Hypertonic Dextrose Prolotherapy (HDP) menawarkan alternatif yang menjanjikan. Penelitian ini bertujuan untuk membandingkan efektivitas suntikan PRP dan HDP pada pasien OA lutut, untuk memberikan wawasan tentang pilihan pengobatan yang optimal. Metode: Penelitian analitik eksperimental ini melibatkan dua kelompok partisipan. Kelompok

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Ghasemi, Mahshid, Faranak Behnaz, and Mohammadreza Minator Sajjadi. "The Effect of Hypertonic Dextrose Injection on the Control of Pain Associated with Knee Osteoarthritis." World Family Medicine Journal/Middle East Journal of Family Medicine 15, no. 8 (2017): 193–200. http://dx.doi.org/10.5742/mewfm.2017.93076.

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Barzegar, Nasrin, Rezvan Ghaderpanah, Hamid Reza Farpour, and Mohammad Esmaeil Ghorbani Nejad. "Comparing Mannitol and Hypertonic Dextrose Injections for Knee Osteoarthritis Pain and Function: A Randomised Trial." Mediterranean Journal of Rheumatology 36, no. 1 (2025): 100. https://doi.org/10.31138/mjr.280224.cmd.

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Constable, P. D., W. W. Muir, and P. F. Binkley. "Hypertonic saline is a negative inotropic agent in normovolumic dogs." American Journal of Physiology-Heart and Circulatory Physiology 267, no. 2 (1994): H667—H677. http://dx.doi.org/10.1152/ajpheart.1994.267.2.h667.

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The inotropic effects of hypertonic saline (HS) and hyperosmotic dextrose (HD; 2,400 mosmol/l, 4 ml/kg) were determined in normovolumic, chloralose-anesthetized, intact (n = 14) and autonomically blocked (n = 8) dogs. Solutions were infused intravenously over 3 min. HS and HD rapidly increased preload in both intact and autonomically blocked dogs, as assessed by significant (P < 0.05) increases in plasma volume, end-diastolic volume, and end-diastolic pressure. In intact dogs, HS produced a nonsignificant decrease in end-systolic elastance (Ees) and a nonsignificant increase in the maximal

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Balaskas, Elias V., Helen Rodela, and Dimitrios G. Oreopoulos. "Effects of Intraperitoneal Infusion of Dextrose and Amino Acids on the Appetite of Rabbits." Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis 13, no. 2_suppl (1993): 490–99. http://dx.doi.org/10.1177/089686089301302s122.

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We studied the effect of Intraperitoneal Infusion of various volumes and concentrations of dextrose (D) and amino acid (AA) solutions, In a variety of peritoneal dialysis schedules on food Intake and biochemical profile in normal and uremic rabbits. Following omentectomy, a peritoneal catheter was implanted. Animals had free access to food, and consumption was measured daily by weight of the remaining food in the cage. We studied the effect of volume (30-50-100 mL/kg), dextrose concentration (0.5-1.5-2.5-4.25-6.6 g/dL) and AA (Travasol based) (2% in Dianeal or glucose-free solution). Dialysis

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Vokes, T. P., P. R. Aycinena, and G. L. Robertson. "Effect of insulin on osmoregulation of vasopressin." American Journal of Physiology-Endocrinology and Metabolism 252, no. 4 (1987): E538—E548. http://dx.doi.org/10.1152/ajpendo.1987.252.4.e538.

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Patients with uncontrolled insulin-dependent diabetes mellitus have elevations in plasma vasopressin that cannot be completely accounted for by recognized stimuli. To determine whether insulin deficiency per se increases plasma vasopressin, we investigated the effect of acute insulin depletion on the osmoregulation of plasma vasopressin in insulin-dependent diabetics. When intravenous insulin infusion was stopped, plasma vasopressin, osmolality, and glucose increased over the ensuing 5 h, whereas plasma sodium decreased, and blood volume and pressure did not change. This increase in vasopressi

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Constable, Peter D., William W. Muir, and Phillip F. Binkley. "Effect of hypertonic saline solution on left ventricular afterload in normovolumic dogs." American Journal of Veterinary Research 56, no. 11 (1995): 1513–21. http://dx.doi.org/10.2460/ajvr.1995.56.11.1513.

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SUMMARY The effects of hypertonic saline solution (hss) and hyperosmotic dextrose (hd; 2,400 mosm/L, 4 mV kg of body weight) on left ventricular afterload were determined in normovolumic, chloralose-anesthetized, autonomically blocked dogs (n = 8). Solutions were infused iv over 3 minutes. Left ventricular afterload was assessed by use of a dual-tipped micromanometer catheter with an electromagnetic fluidvelocity sensor located in the ascending aorta, and the impedance spectrum was calculated after Fourier analysis of signal-averaged aortic pressure and flow signals. Hypertonic saline solution

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Huang, S. "Effects of hypertonic dextrose injection on chronic supraspinatus tendinopathy: A pilot study of randomized controlled trial." Annals of Physical and Rehabilitation Medicine 61 (July 2018): e146. http://dx.doi.org/10.1016/j.rehab.2018.05.326.

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Fouda, A. A. "Change of site of intra-articular injection of hypertonic dextrose resulted in different effects of treatment." British Journal of Oral and Maxillofacial Surgery 56, no. 8 (2018): 715–18. http://dx.doi.org/10.1016/j.bjoms.2018.07.022.

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Nolph, K. D., H. L. Moore, R. Khanna, and Z. J. Twardowski. "Pentoxifylline Does Not Influence Maximum Ultrafiltration Rates and Peritoneal Transport in Rats." Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis 9, no. 2 (1989): 131–34. http://dx.doi.org/10.1177/089686088900900211.

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Previous publications have suggested that peritoneal capillary blood flow and filtration pressure equilibrium may limit ultrafiltration rates with very hypertonic exchanges. Rats were treated with pentoxifylline, which decreases blood viscosity by increasing red blood cell deformability. Decreases in blood viscosity should reduce microcirculatory resistance and increase effective capillary flow. Transport studies were performed after 2, 4, and 8 weeks of therapy with peritoneal dialysis solutions containing 15 grams % dextrose and using 30-min cycles. Even though rats ingested near the maximum

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