Relevant bibliographies by topics / Hyphenated technique

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Academic literature on the topic 'Hyphenated technique'

Author: Grafiati
Published: 4 June 2021
Last updated: 17 June 2025

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Journal articles on the topic "Hyphenated technique"

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Daram Sushma Reddy Department of Pharmaceutical Analysis, Unnava Jaya Surya, Utukuri Satish, Thulugu Dhanalakshmi, Yatavelli Koushit Reddy, and Yanamala Gopi Krishna. "Hyphenated technologies: Transforming analytical approaches with combined methodologies." International Journal of Science and Research Archive 14, no. 1 (2025): 1431–44. https://doi.org/10.30574/ijsra.2025.14.1.0210.

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The hyphenated technique was developed by combining a separation strategy with an on-line spectroscopic detection technology. Currently, a combination of a separation approach with a more sensitive detection technique is the most used method for determining the speciation of trace elements. Before the addition of a detection approach, such hyphenated techniques involved coupling the separation of a unique sample preparation offline. Currently, a separation method (chromatography) and an online spectroscopic detection method are combined to create the hyphenated technique. Over the past two decades, hyphenated analytical methods have undergone amazing advancements that have greatly expanded their applicability in the analysis of biomaterials, natural products, elemental species, explosives, trace elements, and other things. This article discusses recent developments in the use of various hyphenated techniques, such as GC-MS, LC-MS, LC-FTIR, LC-NMR, etc. in a variety of fields, including forensic science, the environment, biotechnology, the various hyphenated techniques, a brief note on their instrumentation and working principles that are used in the current setup of industries. Like-wise their remarkable improvement and efficiency over the past decade. Techniques like single quadrupole inductively coupled mass spectrometry (ICP-Q-MS), ICP- Triple quadrupole mass spectrometry (ICP-QQQ), Liquid Chromatography-Two -dimensional Gas chromatography, mass spectrometry (LC-GCXGC-MS/MS), Two-dimensional liquid chromatography (2D-LC), Fourier transform near-infrared spectroscopy (FT-NIR), etc. are considered as recent improvements in this trend—geography, and pharmaceuticals, among others, with the use of relevant examples.
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Shounak, Mande*. "A Review Article on Hyphenated Techniques Used in Analytical Method and Development." International Journal of Pharmaceutical Sciences 3, no. 1 (2025): 2407–17. https://doi.org/10.5281/zenodo.14762916.

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The hyphenated techniques refers to the combination or synthesis of distinct analytical methodologies. Spectroscopic techniques are mostly paired with chromatographic techniques. After that, an interphase will allow the mixture's separated components from the chromatographic approach to enter the spectroscopic technique. In GC-MS After separation from gas chromatography, ionization and mass spectrometry are added to MS. analysis and measurement of the mass-to-charge ratios of the ions that the mass spectrometer generates from each analysis. GC and MS can be connected by a membrane separator, jet/orifice separator, or effusion separator. The analytical flow cell in LC-NMR coupling was originally designed for continuous flow to NMR. But the requirement for thorough structural evaluation of novel products has resulted in the use of LCMS in stopped-flow mode. The use of LC-MS-MS is increasing continuously at a rapid rate. Hyphenated methods like UV-coupled HPLC. The combination of mass spectrometry (LC-UV-MS) with biological screening has proven to be quite beneficial for a quick analysis of products. Hyphenated procedures pertain to the process of separating, identifying, and the hyphenated procedures demonstrate improved sample analysis in terms of specificity, accuracy, and precision. (1).
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Gould, Oliver, Natalia Drabińska, Norman Ratcliffe, and Ben de Lacy Costello. "Hyphenated Mass Spectrometry versus Real-Time Mass Spectrometry Techniques for the Detection of Volatile Compounds from the Human Body." Molecules 26, no. 23 (2021): 7185. http://dx.doi.org/10.3390/molecules26237185.

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Mass spectrometry (MS) is an analytical technique that can be used for various applications in a number of scientific areas including environmental, security, forensic science, space exploration, agri-food, and numerous others. MS is also continuing to offer new insights into the proteomic and metabolomic fields. MS techniques are frequently used for the analysis of volatile compounds (VCs). The detection of VCs from human samples has the potential to aid in the diagnosis of diseases, in monitoring drug metabolites, and in providing insight into metabolic processes. The broad usage of MS has resulted in numerous variations of the technique being developed over the years, which can be divided into hyphenated and real-time MS techniques. Hyphenated chromatographic techniques coupled with MS offer unparalleled qualitative analysis and high accuracy and sensitivity, even when analysing complex matrices (breath, urine, stool, etc.). However, these benefits are traded for a significantly longer analysis time and a greater need for sample preparation and method development. On the other hand, real-time MS techniques offer highly sensitive quantitative data. Additionally, real-time techniques can provide results in a matter of minutes or even seconds, without altering the sample in any way. However, real-time MS can only offer tentative qualitative data and suffers from molecular weight overlap in complex matrices. This review compares hyphenated and real-time MS methods and provides examples of applications for each technique for the detection of VCs from humans.
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Liu, Jinchao, Andi Wang, Ji Yang, Shiheng Yin, and Xianfeng Yang. "A Universal Positioning System for Coupling Characterization of SEM and AFM." Scanning 2021 (August 12, 2021): 1–10. http://dx.doi.org/10.1155/2021/5550311.

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Hyphenated techniques, providing comprehensive information in various aspects such as constituent, structure, functional group, and morphology, play an important role in scientific research. Nowadays, coupling characterization of the same position in microscale is in great need in the field of nanomaterial research and exploration. In this article, a new hyphenated technique was developed to facilitate the coupling characterization of atomic force microscope (AFM) and scanning electron microscope (SEM) by designing a universal positioning system. The system consisted of a specimen holder with coordinate grids and a software for converting the coordinate values of the same point to fit SEM, specimen holder, and AFM system. In working condition, the coordinates of the labeled points and target position were firstly extracted from the SEM operation software, then converted into the numerical values adapted to the specimen holder itself, and finally transformed into the coordinates matching the AFM system. The experimental result showed that a retrieving rate of 96% was achieved for a spherical target with a diameter of 1 μm in a 30 μ m × 30 μ m square. The hyphenated technique is a universal, accurate, efficient, and financially feasible method in microanalysis field and has great application potential.
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Prem, Lata Meena, Sandilya Avinash, and Sharma Sachin. "A review of Singular and Hyphenated Analytical techniques in Trace Element analysis." Chemistry Research Journal 4, no. 1 (2019): 117–24. https://doi.org/10.5281/zenodo.13752764.

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At micro trace levels there is a critical need for preconcentration, selective separation, and determine the various metal ions from complex matrices. Trace analysis and various&nbsp;analytical techniques which are used to determine the&nbsp;concentration&nbsp;of a&nbsp;chemical element is described. It can be broadly classified in to singular and hyphenated techniques. For analysis there are different types of singular techniques like Flame Atomic absorption spectroscopy (AAS),Neutron activation analysis (NAA),Graphite furnace atomic absorption spectrometry (GFAAS),&nbsp;inductively coupled plasma mass spectrometry&nbsp;(ICP-MS), X-ray fluorescence (XRF) and inductively coupled plasma atomic emission spectroscopy (ICP-AES).<strong>&nbsp;</strong>Hyphenated technique provides an opportunity to avoid contamination and large reagent consumption with good selectivity and high sensitivity.
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Jansen, J. A. J., J. H. Van Der Maas, and A. Posthuma De Boer. "Hyphenated On-The-Spot TG/FT-IR Technique." Applied Spectroscopy 46, no. 1 (1992): 88–92. http://dx.doi.org/10.1366/0003702924444452.

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By the coupling of thermogravimetry (TG) and Fourier transform infrared spectroscopy (FT-IR), the thermal behavior of polymeric materials can be elucidated from their mass loss combined with characterization of the evolved components. A hyphenated TG/FT-IR technique is presented, which enables the direct detection and characterization of evolving components in TG experiments, i.e., without transferring these components from the TG to the FT-IR equipment. In this on-the-spot TG/FT-IR technique, the IR beam of the FT-IR spectrometer is led directly into the TG equipment. The IR beam is reflected by a mirror mounted inside the TG equipment and subsequently detected by a standard FT-IR detector. In this way, the evolved components are detected both in gas and condensed phase directly in the TG equipment. The detection limits are in the sub µg/s range. The experimental setup and conditions are presented together with advantages and applications in the field of polymeric research.
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Meermann, Björn, and Volker Nischwitz. "ICP-MS for the analysis at the nanoscale – a tutorial review." Journal of Analytical Atomic Spectrometry 33, no. 9 (2018): 1432–68. http://dx.doi.org/10.1039/c8ja00037a.

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The scope of this tutorial review is (i) to provide an overview on ICP-MS based techniques for the analysis of ENPs and natural nanoparticles/colloids by (a) “stand alone” ICP-MS and (b) hyphenated techniques; (ii) highlighting the benefits and pitfalls of each technique as well as providing practical advice regarding method development; (iii) illustrating the possibilities and limitations of each technique by practical applications from the recent literature.
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Komal, Zade* Mrunali Ahirrao Madhuri Shirsath Tufail Dana M. B. Nikam. "HPLC and its Hyphenated Techniques: Review." International Journal of Scientific Research and Technology 2, no. 5 (2025): 584–99. https://doi.org/10.5281/zenodo.15529234.

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High Performance Liquid Chromatography (HPLC) is a precise analytical technique used to separate, identify, and quantify components within complex mixtures. Developed in the late 1960s, it operates by pumping a liquid mobile phase under high pressure (50&ndash;350 bars) through a column packed with solid adsorbents like silica or polymers, which interact differently with each sample component to achieve separation. HPLC is favored in pharmaceuticals, biotechnology, environmental testing, and food industries for its speed, sensitivity, and high resolution. Hyphenated techniques in liquid chromatography combine chromatography with spectroscopic methods, a concept introduced by Hirsch Feld in 1980. These integrated systems, such as LC-MS, LC-NMR, and LC-FTIR, use appropriate interfaces to enable simultaneous separation and detailed detection, offering enhanced qualitative and quantitative analysis. These approaches are crucial in modern drug discovery and chemical analysis, providing comprehensive data in a single run.
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Amir, Mohammad, Puneet Narula, and Farzana Bano. "Analytical Techniques for the Analysis of Lopinavir and Ritonavir in Pharmaceutical Dosage Form and Biological Matrices: A Review." Current Pharmaceutical Analysis 18, no. 4 (2022): 380–414. http://dx.doi.org/10.2174/1573412918666211217145200.

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Background: Lopinavir and Ritonavir are protease inhibitor type of anti-retroviral drugs. Both are used for the treatment of HIV/AIDS. This paper reviews many analytical methods for the analysis of LPV and RTV in pharmaceutical formulations (tablet, capsule, syrup, and bulk) and biological fluids (human plasma, serum, cerebrospinal fluid, rat plasma, and human hair). Objective: The study aims to summarize various analytical techniques, such as chromatography and spectrophotometry, and also hyphenated techniques, such as LC-MS/MS and UPLC-MS, for the analysis of Lopinavir and Ritonavir. Method: The review deals with comprehensive details regarding the type of various analytical techniques, such as spectroscopy (UV), chromatography (RP-HPLC, HPTLC, UPLC), and hyphenated techniques, i.e., LC-MS/MS and UPLC-MS, for the analysis of lopinavir and ritonavir. These techniques are either explored for the quantification and detection of metabolite or for stability studies of the LPV and RTV. Conclusion: The studies presented revealed that the HPLC technique along with spectroscopy have been most widely used for the analysis. Out of the developed methods, hyphenated UPLCMS and LC-MS are very sensitive and help in the easy estimation of drugs compared to other techniques. This review may provide comprehensive details to the researchers working in the area of analytical research of LPV and RTV.
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Proch, Jędrzej. "UKŁADY ŁĄCZONE OPARTE NA DETEKCJI PRZY UŻYCIU OPTYCZNEJ SPEKTROMETRII EMISYJNEJ W OZNACZANIU FORM METALI I METALOIDÓW." Wiadomości Chemiczne 79, no. 1 (2023): 61–79. https://doi.org/10.53584/wiadchem.2025.1.4.

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Hydride generation (HG) has become a widely used technique for efficient analyte introduction in optical emission spectrometry, although only few hyphenated systems using this technique have been developed. It was decided to fill this gap using a modified spray chamber that allows with conventional nebulizer and/or as hydride generator, i.e. the Multi-mode Sample Introduction System (MSIS). The MSIS unit was used as an interface between high-performance liquid chromatography (HPLC) and inductively coupled plasma optical emission spectrometry (ICP OES) or microwave induced plasma optical emission spectrometry (MIP OES). In this way, hyphenated techniques were designed, based on three modes of operation of the MSIS chamber: (1) hydride generation for the determination of metalloid species occurring as anions and forming volatile hydrides, (2) conventional sputtering for the determination of metal species occurring as cations, and (3) dual mode for the simultaneous determination of metal and metalloid species occurring as cations and anions. The article is based on the doctoral dissertation of Jędrzej Proch entitled: "Hyphenated systems based on detection by optical emission spectrometry in determination of metals and metalloids species”, distinguished by the Discipline Council of Chemical Sciences at Adam Mickiewicz University and awarded by the Committee of Analytical Chemistry of the Polish Academy of Sciences in 2024 in the competition for the best doctoral dissertation in analytical spectrometry, the prize funded by MS Spektrum.
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Dissertations / Theses on the topic "Hyphenated technique"

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Harris, Dee. "Design and development of a hyphenated technique for monitoring the cure of epoxy-amine resin systems." Thesis, University of Birmingham, 2011. http://etheses.bham.ac.uk//id/eprint/2872/.

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The main focus of the current study was to design, construct and evaluate a common platform to enable the integration of multiple sensing systems for cure monitoring. An Abbe refractometer was selected to house a custom-made cell which accommodated the following optical sensors: (i) Fresnel reflection sensor; (ii) near-infrared transmission sensor; (iii) evanescent wave sensor; and (iv) fibre Bragg grating sensor. The cell was designed such that it was also possible to simultaneously acquire conventional refractive index data during the cross-linking process. Thus, the cross-correlation of data on refractive index, cross-linking kinetics, strain and temperature was facilitated. It was found that the trends observed in the qualitative (intensity-based refractive index monitoring via the Fresnel reflection sensor) and quantitative (optical fibre-based transmission FTIR spectroscopy) approaches were similar during the cure of common thermosetting resin systems. Furthermore, for the first time, S-2 glass® fibres were used to obtain evanescent wave spectra during cross-linking, and excellent correlation was observed with the transmission FTIR spectral data. Fibre Bragg grating sensors were used to infer the magnitude of the residual fabrication strain. Excellent correlation was observed between the refractive index data generated using the Abbe refractometer and Fresnel reflection sensor.
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Fedrizzi, Bruno. "Identification, quantitation and origin of sulfur compounds in grape products. An approach via hyphenated mass spectrometry techniques." Doctoral thesis, Università degli studi di Padova, 2010. http://hdl.handle.net/11577/3426543.

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The contribute of the Analytical Chemistry in the study of complex matrices, as for instance foodstuff, is crucial. In particular the development of chromatographic methods allows to quantify important technological, microbiological and physiological markers. The ensemble of all these information furthers a deeper and higher knowledge. This Ph.D. project was designed to define the tools and evaluate the contribution of an important class of molecule on wine aroma. Grape products are really important in the cultural and dietary Italian traditions; moreover Italy is both the first producer and the first consumer around the world. Oenological products have been largely studied since the early ’70, even if the lack of biochemical and microbiological knowledge and the poor sensitivity of the analytical techniques did not allow to carry an deep study on sulfur compounds. This project, planned to bid analytical and oenological chemistry, focussed its attention on the study of sulfur compounds. Dealing with complex matrices, the first problem we had to face was the matrix effects. The overcoming of such issue or the attempts in reducing it, costs to chemical laboratory, wasting of time and money to prepare suitable internal standards. In this thesis we proposed a statistical approach based on the variance component model able to handle matrix effects. The benefits obtained by this approach definitely outweigh both the slightly worse sensitivity and uncertainty. Another topic discussed in the thesis is the definition of analytical methods to quantify sulfur compounds. This subject has been studied distinguishing sulfur compounds into two sub-groups: o fermentative sulfur compounds: molecules produced by yeast metabolisms from amino acidic precursors. o varietal sulfur compounds: molecules present in specific variety, as conjugated with cysteine and glutathione. The free forms, which are sensorially active, are released during fermentation by means of a specific enzymatic activity. This further classification was kept in the development of the analytical methods because the two classes required different sensitivity as well as metabolomics study were separated. Concerning fermentative sulfur compounds a HS-SPME/GC-MS method was optimised and validated. With this method a wide range of sulfur compounds were quantified. Such tool was applied to metabolomic studies, concerning the influence of variety, ageing, yeast strain and other technological practice on the level of 13 fermentative sulfur compounds. The results obtained from the development of the analytical method permitted to highlight the potentiality of the HS-SPME technique in sampling volatile compounds in complex matrices. This approach allows an easier and safer lab conditions, avoiding the use of organic solvents. The metabolomic studies furnished important suggestion on the influence of important oenological variables on the level of important sulfur compounds. The last topic discussed in this thesis concerns the study of varietal sulfur compounds. The lack of suitable analytical technique, sufficiently rapid and avoiding the use of mercuro-organic compounds stimulated our research in verifying the performance of headspace technique in extracting these analytes. We optimised and validated HS-SPME and purge and trap methods and finally we defined a non-parametric robust approach to compare performances from different analytical methods. Owing to the recent interest of the scientific research in trying to understand the formation and evolution of varietal sulfur compounds, we focussed our attention on their precursors. The first step was the synthesis of the putative precursors, followed by the optimisation of LC-MS/MS methods to quantify them. It was possible to identify a new precursor by LC-MS/MS experiments. Finally, by the isolation of the enzyme potentially responsible of the biosynthesis of the varietal thiols precursors, we gave a preliminary explanation of the formation of these glutathionylated precursors during grape ripening. By this project it has been possible to study and apply the newest analytical techniques available and it has been possible to define statistical procedures to overcome the most common issues in studying complex matrices. Furthermore it was clarified the contribution of an important class of molecules, such as sullfur compounds, on oenological matrices.<br>Il contributo della Chimica Analitica nello studio delle matrici complesse, quali ad esempio quelle alimentari, è cruciale. In particolare lo sviluppo di metodi cromatografici avanzati può permettere di dosare importanti marker tecnologici, microbiologici e fisiologici e quindi consentire un approfondimento delle attuali conoscenze. Questo lavoro è stato concepito allo scopo di definire gli strumenti per valutare il contributo di un’importante classe di molecole all’aroma dei vini. Il vino riveste un ruolo di primaria importanza nelle tradizioni culturali ed alimentari Italiane, inoltre l’Italia risulta primo produttore e primo consumatore mondiale di vino. I prodotti enologici sono stati largamente studiati fin dai primi anni ’70, anche se l’assenza di conoscenze biochimiche e microbiologiche e la mancanza di tecniche analitiche sufficientemente sensibili non ha consentito lo studio esaustivo della classe dei composti solforati. Questa tesi, nata da esigenze legate alla chimica analitica e alla chimica enologica, ha avuto come punto centrale lo studio dei composti solforati nei vini. Il primo problema che si è dovuto affrontare nello studio di matrici complesse come quelle enologiche è stato quello relativo agli effetti matrice. Il superamento o il contenimento di questo problema crea ogni giorno costi in termini di tempo e di preparazione di opportuni standard interni. In questa tesi si è proposto un metodo statistico basato sul modello a componente di varianza in grado di gestire questo problema. I vantaggi sono notevoli, a fronte di una incertezza leggermente maggiore e di una sensibilità di poco peggiorata. Altro argomento trattato è stata la definizione dei metodi analitici in grado di quantificare e quindi di studiare i composti solforati. Questa materia è stata affrontata riconoscendo una prima distinzione all’interno del gruppo degli analiti indagati: o composti solforati fermentativi: molecole derivanti dal metabolismo del lievito a partire da precursori amminoacidici o composti solforati varietali: molecole presenti in specifiche varietà come coniugati della cisteina e del glutatione e rilasciati durante la fermentazione alcolica ad opera di specifiche attività enzimatiche. Questa suddivisione è stata mantenuta anche nello sviluppo dei metodi analitici, in quanto sensibilità richieste e conseguenze metabolomiche erano anch’esse distinte. Per quanto riguarda i composti solforati fermentativi, durante il dottorato di ricerca è stato ottimizzato e validato un metodo HS-SPME/GC-MS per l’analisi di un’ampia gamma di molecole tipicamente derivanti dal metabolismo del lievito. Tale approccio è poi stato la base per studi di natura più squisitamente metabolomica in cui è stato verificato come il cultivar (i.e. la varietà), l’invecchiamento, il ceppo di lievito e altre pratiche tecnologiche potessero influenze il livello e l’evoluzione degli analiti indagati. I risultati ottenuti per quanto attiene lo sviluppo del metodo in spettrometria di massa hanno potuto confermare con la tecnica SPME con campionamento in spazio di testa sia una tecnica di elezione per l’analisi di molecole volatili. Inoltre questo approccio consente una gestione semplice ed enviromental friendly in confronto con i più obsoleti metodi di estrazione con solvente. Gli studi metabolomici hanno consentito di trarre importanti considerazioni su aspetti molto importanti nella definizione della qualità del prodotto finale. Tali risultati consentono anche una trasferibilità nei settori della ricerca applicata e dell’enologia. Come ultima classe di analiti indagati si sono studiati i composti solforati varietali. L’assenza di metodi sensibili e sufficientemente rapidi da essere applicati per studi su un numero significativo di campioni ha spinto la nostra attenzione alla verifica delle potenzialità delle tecniche in spazio di testa nel dosare queste molecole. Si sono ottimizzati e validati metodi HS-SPME e purge and trap ed è stata definita una procedura non parametrica robusta per il confronto delle performance delle diverse procedure. Visto il recente interesse della ricerca scientifica operante nel settore al controllo della formazione ed evoluzione di queste molecole, abbiamo focalizzato la nostra attenzione sui precursori dei composti solforati varietali. Il primo stadio è stata la sintesi di queste molecole, seguito poi dall’ottimizzazione di metodi LC-MS/MS per il dosaggio di queste molecole. In questo contesto è stato possibile identificare per la prima volta un nuovo potenziale precursore di aroma, tramite esperimenti LC-MS/MS. Da ultimo, attraverso l’isolamento dell’enzima responsabile della biosintesi dei precursori d’aroma è stato possibile proporre una preliminare spiegazione alla formazione di tali molecole durante la maturazione della materia prima. In conclusione, grazie a questa tesi di dottorato, è stato possibile approfondire ed applicare alcune delle più moderne tecniche analitiche a disposizione, è stato possibile definire procedure statistiche per superare i più comuni ostacoli nello studio di matrici complesse, ed è stato possibile chiarire il contributo di una classe importante di molecole come i composti solforati nelle matrici enologiche.
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Homazava, Nadzeya. "Development of a novel microflow-capillary technique online hyphenated to the inductively coupled plasma mass spectrometry for the spatial- and time-resolved investigation of local corrosion /." [S.l.] : [s.n.], 2009. http://opac.nebis.ch/cgi-bin/showAbstract.pl?sys=000288126.

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Wang, Tongwen. "Hyphenated HPLC-MS technique for analysis of compositional monosaccharides of transgenic corn glycoprotein and characterization of degradation products of diazinon, fonofos and aldicarb in various oxidation systems." Diss., Rolla, Mo. : University of Missouri-Rolla, 2007. http://scholarsmine.mst.edu/thesis/pdf/WangTongwen_09007dcc804e975c.pdf.

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Thesis (Ph. D.)--University of Missouri--Rolla, 2007.<br>Vita. The entire thesis text is included in file. Title from title screen of thesis/dissertation PDF file (viewed April 23, 2008) Includes bibliographical references.
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Jordan, Sheri Lynne. "Hyphenated fourier transform infrared spectrometry : techniques for separations and analysis /." Diss., This resource online, 1995. http://scholar.lib.vt.edu/theses/available/etd-08282003-155254/.

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Kapoore, Rahul Vijay. "Mass spectrometry based hyphenated techniques for microalgal and mammalian metabolomics." Thesis, University of Sheffield, 2014. http://etheses.whiterose.ac.uk/8234/.

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In metabolomics, the analytical challenge is to capture the chemical diversity of the metabolome. With the current technologies only a portion of the metabolome can be analysed. As a result there is a drive to direct significant analytical efforts towards capturing the metabolome or changes in the metabolome reliably and reproducibly in biological systems. Apart from analytical challenges, the challenges also include development of appropriate methodologies to quench and extract metabolites which is a crucial parameter in sample preparation and is required to achieve an accurate representation of phenotype. This thesis focuses on addressing both the challenges in mammalian and microalgal metabolomics. Metabolomics in cancer research is gaining momentum as a tool to understand the molecular mechanism of disease progression and for the identification of specific biomarkers which may assist distinguishing between normal, benign and metastatic cancer states. In our first investigation we developed GC-MS based modified direct cell scraping, bead harvesting and LN2 methods for harvesting three adherently grown mammalian cell lines (two breast cancer cell lines MDA-MB 436, MCF7 and an endothelial cell line HMEC1) which provided rapid and reliable route with three fold improved metabolome coverage and reduced the artifacts due to metabolome leakage compared to conventional methods. Later optimized treatments were employed and the influence of various washing and quenching solvents (buffered/unbuffered) on metabolite leakage was investigated for metastatic cancer cell line MDA-MB-231. This identified one washing step with PBS followed by quenching with 60% methanol (buffered with HEPES) as the best washing and quenching solvents. Further validation and comparison of proposed workflows for metabolomic study of two metastatic TNBC cell lines (MDA-MB-231 and MDA-MB-436) resulted in recovery of 154 unique metabolites and demonstrated the robustness and reliability of these methods in pathway based analysis in cancer. In case of GC-MS based microalgal metabolomics, with comprehensive evaluation of selected quenching and extraction methods in model microalga C. reinhardtii, we have successfully demonstrated that the choice of quenching and extraction solvents have significant impact on recovery of different classes of metabolites. Our results clearly indicate that 60% methanol (buffered with HEPES) and 25 % aqueous methanol are the best suited quenching and extraction solvent respectively for untargeted metabolomic analysis of C. reinhardtii, as the highest number of metabolites belonging to various chemical classes were recovered with good intensities and reproducibilities with this miniaturized proposed method compared to other evaluated methods. Later impact of various stages involved in biodiesel production workflow from microalga on recovery of biodiesel was assessed in three microalgal species namely C. reinhardtii, D. salina and N. salina. Within which we have developed an optimized GC-FID method and miniaturized direct TE method for quantification of fatty acids, which can be applied to a small amount of biomass and saves tremendous amounts of time, solvents and reagents required, is less expensive and uses environment friendly solvents making it more suitable for sustainable large scale production. In our final investigation, we directed our efforts towards preliminary optimization and comparative analysis of HILIC and IP-RP-HPLC based separation for the retention and separation of specific metabolites classes. This identified HILIC as the best available column till date for untargeted metabolomic studies. The descriptive understanding gained from each of these investigations provides greater insight into biology of mammalian and algal systems by improving the metabolome coverage for various metabolite classes. These insights illustrating the underlying molecular pathways involved in respective biology's, will help scientific communities in identifying as-of-yet-missing reactions in the metabolic network. In addition these insights will surely help in generating many hypothesis based investigations in microalgal and cancer community.
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Bailey, Nigel John Collingwood. "Development and application of hyphenated NMR techniques to the study of agrochemical metabolism." Thesis, Imperial College London, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.394243.

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Wangkarn, Sunanta. "Development of hyphenated analytical techniques for arsenic speciation in environmental and biological matrices." Thesis, Birkbeck (University of London), 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.342227.

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Williams, Samuel Thomas. "Analysis of erythropoietin for anti-doping purposes with a focus on hyphenated techniques." Thesis, King's College London (University of London), 2014. https://kclpure.kcl.ac.uk/portal/en/theses/analysis-of-erythropoietin-for-antidoping-purposes-with-a-focus-on-hyphenated-techniques(8b6d26e7-a9c5-4d5a-9e3a-f32be79939e2).html.

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To improve detection of the misuse of erythropoietin (EPO) for performance enhancing purposes, this PhD examined ways to improve recovery and preanalysis concentration of EPO from urine. It also looked at ways to enhance the signal in liquid chromatography tandem mass spectrometry of the acidic glycopeptides from digested EPO, and at distinguishing between recombinant EPO and human urinary EPO based on differences in their glycosylation. Due to a shortage of supply of available analytical standards, model glycoproteins were frequently used in place of endogenous EPO. Immunoextraction with magnetic beads effectively recovered EPO from urine which had been filtered to remove large proteins, but was unsuccessful from unfiltered urine, suggesting more research into the right choice of antibody was needed. The specific and reversible binding of boronic acids to cis-diol groups found in the glycan groups of glycoproteins was investigated as a device for the selective binding of EPO. Attempts were made to functionalise mesoporous silica for use as a column packing material. Although there was evidence that at least one method of functionalisation was successful, the use of this silica to extract glycoproteins and glycopeptides was not. Signal enhancement through the introduction of ‘superchargers’ into LC solvents was investigated. This was effective with small molecules, and also improved detection of sialylated glycopeptides. The results do not fit entirely with current models of how superchargers exert their effect, suggesting they are incomplete. Finally, the cleavage, digestion and derivatisation of N-glycans to identify bisected and non-bisected structures as a way to discriminate between rEPO and huEPO was examined. Samples were analysed using LC-MS and CE-LIF, and although much of the work was carried out using a model glycoprotein, there is some evidence that the approach may be capable of discriminating between artificial and endogenous EPO at the levels found in anti-doping samples.
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10

Prazen, Bryan J. "Development of high speed hyphenated chromatographic analyzers and second order data analysis techniques /." Thesis, Connect to this title online; UW restricted, 1998. http://hdl.handle.net/1773/11550.

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Books on the topic "Hyphenated technique"

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Zdeněk, Deyl, ed. Directory of hyphenated techniques. Elsevier, 1994.

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Lobinski, Ryszard, and Joanna Szpunar, eds. Hyphenated Techniques in Speciation Analysis. Royal Society of Chemistry, 2003. http://dx.doi.org/10.1039/9781847551092.

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Provder, Theodore, Marek W. Urban, and Howard G. Barth, eds. Hyphenated Techniques in Polymer Characterization. American Chemical Society, 1994. http://dx.doi.org/10.1021/bk-1994-0581.

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Karjalainen, E. J. Data analysis for hyphenated techniques. Elsevier, 1996.

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Joanna, Szpunar, and Lobinski Ryszard, eds. Hyphenated techniques in speciation analysis. Royal Society of Chemistry, 2003.

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Rosenfeld, J. M., ed. Sample Preparation for Hyphenated Analytical Techniques. Blackwell Publishing Ltd., 2004. http://dx.doi.org/10.1002/9781444305500.

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M, Rosenfeld J., ed. Sample preparation for hyphenated analytical techniques. Blackwell, 2004.

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Flamini, Riccardo, ed. Hyphenated Techniques in Grape and Wine Chemistry. John Wiley & Sons, Ltd, 2008. http://dx.doi.org/10.1002/9780470754320.

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Silva Elipe, Maria Victoria. LC-NMR and Other Hyphenated NMR Techniques. John Wiley & Sons, Inc., 2011. http://dx.doi.org/10.1002/9781118135396.

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1939-, Provder Theodore, and American Chemical Society Meeting, eds. Chromatography of polymers: Hyphenated and multidimensional techniques. American Chemical Society, 1999.

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Book chapters on the topic "Hyphenated technique"

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Graboski, Adriana Marcia, Sandra Cristina Ballen, Juliana Steffens, and Clarice Steffens. "Hyphenated Electronic Nose Technique for Aroma Analysis of Foods and Beverages." In Food Aroma Evolution. CRC Press, 2019. http://dx.doi.org/10.1201/9780429441837-9.

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Chua, Lee Suan. "Hyphenated Technique of LC-PDALC-PDA -MS/MS for Phytochemical Profiling of Ficus deltoidea." In Crystallizing Ideas – The Role of Chemistry. Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-31759-5_4.

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Falkenhagen, Jana, and Steffen Weidner. "Hyphenated Techniques." In Mass Spectrometry in Polymer Chemistry. Wiley-VCH Verlag GmbH & Co. KGaA, 2012. http://dx.doi.org/10.1002/9783527641826.ch7.

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Scholz, Fritz, Uwe Schröder, Rubin Gulaboski, and Antonio Doménech-Carbó. "Hyphenated Techniques." In Electrochemistry of Immobilized Particles and Droplets. Springer International Publishing, 2014. http://dx.doi.org/10.1007/978-3-319-10843-8_4.

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Sarker, Satyajit D., and Lutfun Nahar. "Hyphenated Techniques." In Natural Products Isolation. Humana Press, 2006. http://dx.doi.org/10.1385/1-59259-955-9:233.

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Feng, Xiao, Yunchang Guo, Hongjie An, and Hongshun Yang. "The Hyphenated Technique of High Speed Atomic Force Microscopy and Super Resolution Optical Detection System." In Atomic Force Microscopy in Molecular and Cell Biology. Springer Singapore, 2018. http://dx.doi.org/10.1007/978-981-13-1510-7_6.

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Barth, Howard G. "Hyphenated Polymer Separation Techniques." In Advances in Chemistry. American Chemical Society, 1995. http://dx.doi.org/10.1021/ba-1995-0247.ch001.

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Webb, Andrew. "Small-Volume Hyphenated NMR Techniques." In Micro and Nano Scale NMR. Wiley-VCH Verlag GmbH & Co. KGaA, 2018. http://dx.doi.org/10.1002/9783527697281.ch12.

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Fetzer, John C. "Hyphenated Techniques for Chromatographic Detection." In Handbook of Spectroscopy. Wiley-VCH Verlag GmbH & Co. KGaA, 2005. http://dx.doi.org/10.1002/3527602305.ch21.

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Urban, Marek W. "Synergism of Hyphenated Techniques in Polymer Analysis." In ACS Symposium Series. American Chemical Society, 1994. http://dx.doi.org/10.1021/bk-1994-0581.ch001.

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Conference papers on the topic "Hyphenated technique"

1

Mills, George, Bob Bell, and E. Lynn Shirey. "The Characterization of Coatings Utilizing Thermal Extract Ion/Gas Chromatography Followed by Fourier Transform Infrared Spectroscopy and/or Mass Spectrometry." In CORROSION 1994. NACE International, 1994. https://doi.org/10.5006/c1994-94440.

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Abstract The characterization of coatings utilizing thermal extraction/gas chromatography followed by fourier transform infrared spectroscopy and/or mass spectrometry is a very powerful hyphenated technique capable of providing definitive answers to questions of QA/QC during the development of a paint formulation, during its manufacture, during its application, or during its investigation after a coating failure. Small recovered paint chips reveal a portion of their past history. Positive identification of generic binder types, solvent entrapment, unreacted monomer, and improper catalyzation are demonstrated. Plastic type and degree of degradation may be identified. An introduction to the versatility of the instrument is presented.
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HU, Jian-wen, Meng-meng LIU, Ji-zhong HAN, and Bin ZENG. "Antibiotics and ELISA as a Hyphenated Technique for Screening High Production Cell Lines from Transfected HEK293 Cells for the Production of Recombinant Follicle Stimulating Hormone." In 2nd International Conference on Biomedical and Biological Engineering 2017 (BBE 2017). Atlantis Press, 2017. http://dx.doi.org/10.2991/bbe-17.2017.2.

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Girase, Tejasweeni, Javesh Patil, Aayushi Tatiya, Devyani Patil, and Mamta Patil. "Clomiphene Citrate as Nanomedicine Assistance in Ovulatory Disorders and Its Hyphenated Techniques." In IOCN 2023. MDPI, 2023. http://dx.doi.org/10.3390/iocn2023-14505.

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Gosav, Steluta, Nicoleta Paduraru, and Mirela Praisler. "Hyphenated GC-FTIR and GC-MS techniques applied in the analysis of bioactive compounds." In Second International Conference on Applications of Optics and Photonics, edited by Manuel Filipe P. C. Martins Costa and Rogério Nunes Nogueira. SPIE, 2014. http://dx.doi.org/10.1117/12.2063898.

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Colletti, Marjan. "Postdigital Architecture. What Now?!" In Design Computation Input/Output 2022. Design Computation, 2022. http://dx.doi.org/10.47330/dcio.2022.kkrr9918.

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The hyphenated term ‘post-digital’ was coined over twenty years ago by sonic artist Kim Cascone as a means of thinking about the aesthetics of the time beyond the digital revolution in electronic music, and then adopted in the arts, media, and architecture. In architecture, the term has been adopted to promote an anti-digital ‘downgrading’ aesthetic agenda: as post(minus)digital. However, if understood as post(plus)digital – in short: postdigital – the expression appears to be indicative of an evolution of the digital beyond its first implementation as numerical or virtual alternative to traditional analogue design and making techniques. What postdigital traits and characteristics can be identified? How can they be implemented in architectural design? Why does it matter?
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Reports on the topic "Hyphenated technique"

1

Wai, Chien M., and Bruce Mincher. Ionic Liquid and Supercritical Fluid Hyphenated Techniques for Dissolution and Separation of Lanthanides, Actinides, and Fission Products. Office of Scientific and Technical Information (OSTI), 2012. http://dx.doi.org/10.2172/1058920.

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