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Journal articles on the topic 'Hypocoagulation'
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Lycheva, N. A., I. I. Shakhmatov, and S. V. Moskalenko. "Comparative characteristics of the hemostasis system state during hypothermic and early reactive periods of general freeze injury in rats." Kazan medical journal 98, no. 6 (2017): 989–93. http://dx.doi.org/10.17750/kmj2017-989.
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Aim. To study the hemostasis system state in rats during hypothermic and post-hypothermic periods. Methods. Male Wistar rats (53 individuals) were used in the study. The animals from the experimental group underwent single immersion cooling in water at a temperature of 5 °C until profound hypothermia was reached, the control group of the animals was placed in water at a temperature of 30 °C. From the animals of the first group, blood was taken immediately after reaching profound hypothermia and from the second group - 24 hours after cooling was stopped. Results. Comparative analysis of the results showed that immediately after the end of a single cold exposure, significant increase in platelet aggregation activity occured, as well as appearance of thrombinemia markers in the bloodstream and inhibition of fibrinolytic system activity. 24 hours after the experimental exposure, these parameters returned to the initial values. When assessing the activity of external and internal ways of coagulation immediately after the termination of cooling, development of hypocoagulation was established, both with routine tests and from thromboelastography. After 24-hour period, hypocoagulation, recorded immediately after reaching the sought rectal temperature, persisted. Thus, after the end of a 24-hour period after cold exposure termination, most of the parameters of hemostatic system that had deviated immediately after the end of the experiment, returned to the normal level. The delayed effect of hypothermia in such cold exposure regimen manifested only by hypocoagulative shift at the initial stages of coagulation. Conclusion. Signs of abnormal hemostasiological blood properties, recorded immediately after the cooling termination, disappear within 24 hours, and only hypocoagulation persists in the blood.
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Schött, Ulf, and Thomas Kander. "Prolonged TTM – enhanced hypocoagulation and bleeding?" Resuscitation 118 (September 2017): A3—A4. http://dx.doi.org/10.1016/j.resuscitation.2017.07.001.
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Mironov, N. P., V. A. Svetlov, A. V. Vabishchevich, A. I. Krupatkin, and S. A. Fedotov. "Correction of vascular, thrombocytic and coagulative system of homeostasis in trauma and orthopaedic microsurgery." N.N. Priorov Journal of Traumatology and Orthopedics 5, no. 4 (1998): 36–40. http://dx.doi.org/10.17816/vto104850.
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To improve the blood circulation during reconstructive operations with microsurgical technique acelysin (1.920.19 mg/kg) and clexane (0.590.07 mg/kg) was applied intra- and postoperatively in 16 and 11 patients, respectively. Control group included 12 patients. The study of coagulative, vascular and thrombocytic systems showed that the drugs were effective to keep up moderate blood hypocoagulation during and after long microsurgical operations. Acelysin provided prolonged hypocoagulation state while clexane had less prolonged and more slight effect.
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Enikeeva, D. A., V. N. Byzova, I. K. Sarycheva, G. N. Sytnik, N. A. Sokolova, and R. P. Evstigneeva. "Testing activity of phytomenadione during experimental hypocoagulation." Pharmaceutical Chemistry Journal 19, no. 1 (1985): 29–32. http://dx.doi.org/10.1007/bf00767100.
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Mykhailovskyi, Ya M. "The influence of clinical and genetic factors on the stability of warfarin’s anticoagulant effect in patients with atrial fibrillation." Pathologia 19, no. 1 (2022): 12–17. http://dx.doi.org/10.14739/2310-1237.2022.1.252662.
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The aim. To investigate the influence of clinical and genetic factors on the stability of warfarin’s anticoagulant effect in patients with atrial fibrillation (AF) during the year. Materials and methods. The study involved 60 patients with AF, age 70.50 (64.25; 76.25) years (32 men and 28 women). Coagulogram indexes with International Normalized Ratio (INR) were determined using Coag Chrome 3003 monthly; the CHA2DS2-VASC, HAS-BLED, SAMe-TT2R2 scales scores were evaluated; the calculation of TTR was performed using the Rosendaal method. CYP2C9, CYP4F2, VKORC1 genes polymorphisms were determined using multiplex real time polymerase chain reaction in CFX-96 thermocycler (BioRad). Results. Median TTR in groups of patients with SAMe-TT2R2 score <2 (n = 33) and ≥2 (n = 27) did not differ significantly (74 % versus 68 % respectively, P > 0.05). There were significantly more patients with TTR <70 % in the group with predicted labile INR (59.36 % versus 30.30 %; χ2 = 5.07, P < 0.05). SAMe-TT2R2 score ≥2 increased the risk of poor INR control by 1.96 times (CI 1.05–3.63). No association of TTR with CYP2C9, CYP4F2 and VKORC1 gene polymorphisms was found. Episodes of excessive hypocoagulation (INR >4) were detected in 21 (40 %) patients during the year. Excessive hypocoagulation was significantly more common in patients carrying the allele A of the VKORC1 gene in comparison with non-carriers (51.43 % versus 24.00 %; χ2 = 4.57, P < 0.05). The presence of mutant allele A was associated with 2.14-fold higher risk of excessive hypocoagulation (RR = 2.14; CI 1.06–4.69). Taking amiodarone (χ2 = 3.13; P < 0.05) had a significant effect on the development of excessive hypocoagulation with a relative risk RR = 1.83 (CI 1.01–3.35). Conclusions. SAMe-TT2R2 score can be useful to predict poor INR control, while VKORC1 genotype estimating – to predict excessive hypocoagulation episodes. An integrated approach using clinical and genetic methods is needed to determine the potential efficacy and safety of warfarin therapy.
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Bulanov, Andrey Y., Ekaterina L. Bulanova, Irina B. Simarova, et al. "Integral assays of hemostasis in hospitalized patients with COVID-19 on admission and during heparin thromboprophylaxis." PLOS ONE 18, no. 6 (2023): e0282939. http://dx.doi.org/10.1371/journal.pone.0282939.
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Background Blood coagulation abnormalities play a major role in COVID-19 pathophysiology. However, the specific details of hypercoagulation and anticoagulation treatment require investigation. The aim of this study was to investigate the status of the coagulation system by means of integral and local clotting assays in COVID-19 patients on admission to the hospital and in hospitalized COVID-19 patients receiving heparin thromboprophylaxis. Methods Thrombodynamics (TD), thromboelastography (TEG), and standard clotting assays were performed in 153 COVID-19 patients observed in a hospital setting. All patients receiving treatment, except extracorporeal membrane oxygenation (ECMO) patients (n = 108), were administered therapeutic doses of low molecular weight heparin (LMWH) depending on body weight. The ECMO patients (n = 15) were administered unfractionated heparin (UFH). Results On admission, the patients (n = 30) had extreme hypercoagulation by all integral assays: TD showed hypercoagulation in ~75% of patients, while TEG showed hypercoagulation in ~50% of patients. The patients receiving treatment showed a significant heparin response based on TD; 77% of measurements were in the hypocoagulation range, 15% were normal, and 8% remained in hypercoagulation. TEG showed less of a response to heparin: 24% of measurements were in the hypocoagulation range, 59% were normal and 17% remained in hypercoagulation. While hypocoagulation is likely due to heparin treatment, remaining in significant hypercoagulation may indicate insufficient anticoagulation for some patients, which is in agreement with our clinical findings. There were 3 study patients with registered thrombosis episodes, and all were outside the target range for TD parameters typical for effective thromboprophylaxis (1 patient was in weak hypocoagulation, atypical for the LMWH dose used, and 2 patients remained in the hypercoagulation range despite therapeutic LMWH doses). Conclusion Patients with COVID-19 have severe hypercoagulation, which persists in some patients receiving anticoagulation treatment, while significant hypocoagulation is observed in others. The data suggest critical issues of hemostasis balance in these patients and indicate the potential importance of integral assays in its control.
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Galstyan, G. M., O. A. Polevodova, A. Yu Gavrish, et al. "Thrombotic events in patients with hemophilia." Terapevticheskii arkhiv 89, no. 7 (2017): 76–84. http://dx.doi.org/10.17116/terarkh201789776-84.
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The paper describes 4 clinical cases of thrombotic events (pulmonary embolism, deep vein thrombophlebitis, acute myocardial infarction, ischemic stroke) that have occurred in patients with hemophilia. It discusses the possible causes of their development and methods for their prevention and treatment. Controlled natural hypocoagulation, in which the dose of an administered deficient factor decreases to such an extent that in order to maintain the safe level of hypocoagulation (plasma factor activity is 15—20%; activated partial thromboplastin time is 1.5—2 times normal values), is proposed as one of the treatment options.
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Česnauskaitė, Agnė, Andrius Montrimas, Diana Rinkūnienė, and Aras Puodžiukynas. "ANTICOAGULATION BEFORE AND AFTER CARDIOVERSION OR ABLATION. CHALLENGES, PROBLEMS AND MISTAKES." Health Sciences 31, no. 1 (2021): 65–70. http://dx.doi.org/10.35988/sm-hs.2021.014.
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Background: Limited data exists addressing the daily use of anticoagulants for atrial fibrillation (AF) and atrial flutter (AFL) patients before and after electrical cardioversion (ECV) or catheter ablation procedures. The purpose of the study was to evaluate the appropriateness of anticoagulant therapy. Methods: We evaluated the prescribed dosage of anticoagulant therapy for 257 non-valvular AF and AFL patients scheduled for ECV or catheter ablation and the appropriateness of periprocedural anticoagulation according to European Society of Cardiology (ESC) AF Guidelines. The statistical analysis was performed using IBM SPSS Statistics software (v.26.0). Results: The majority of the patients (84%) used nonvitamin K antagonist oral anticoagulants (NOACs) for pre-procedural anticoagulation. An intervention was not performed for 12.2% of warfarin users because of insufficient hypocoagulation, while anamnesis of patients’ missed doses with a possibility of inadequate hypocoagulation occurred only in 1.9% of patients on NOACs. The odds of having insufficient pre-procedural hypocoagulation were 7.4 times higher for warfarin users compared to the NOACs group (p=0.001, OR=7.4). An incorrect NOAC dose was assigned to 22 (8.6%) patients. Rivaroxaban was the most prescribed NOAC and this group of patients had the highest percentage of incorrect dosage according to the ESC guidelines. Conclusions: Mistakes of prescribing the dosage of anticoagulant therapy are common. The majority of the patients in the study were prescribed with NOACs before and after ECV or catheter ablation procedures. Warfarin users had higher odds of the intervention not being performed and not reaching sufficient hypocoagulation prior to the procedure compared to NOACs users.
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Hasanov, A. G., M. A. Nurtdinov, and A. F. Badretdinov. "Drug-Induced Hypocoagulation: Results of Emergency Surgical Treatment." Creative surgery and oncology 10, no. 1 (2020): 33–38. http://dx.doi.org/10.24060/2076-3093-2020-10-1-33-38.
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Ngo, Tuan Hưng, Nhu Lam Nguyen, Hai An Nguyen, Dinh Hung Tran, and Le Nguyet Minh Tran. "To evaluate safety of the adsorption hemofiltration technique for treatment of septic shock in severe burn patients." Tạp chí Y học Thảm hoạ và Bỏng, no. 6 (December 28, 2024): 22–28. https://doi.org/10.54804/yhthvb.6.2024.340.
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Objectives: Evaluating the safety of continuous hemofiltration using an adsorbent membrane to treat septic shock in severe burns patients. Subjects and methods: The study describes 55 episodes of septic shock in 38 severe burn patients (16 - 60 years old) treated at the Intensive Care Unit, Le Huu Trac National Burn Hospital from January 2023 to June 2024. Results: The total number of filters used was 247, of which 8 filters had frozen membranes (3.2%), the average life of the filter was 15.87 hours. There were no cases of systolic blood pressure falling below 90 mmHg when entering the filter. During continuous veno-venous hemodiafiltration (CVVHDF): Body temperature was always within allowable limits; there were no differences in blood potassium levels, blood protein and albumin concentration, and hypocoagulation disorders at all time points (p > 0.05); blood sodium concentration decreased significantly to normal limits (p < 0.01). There was no difference in hypocoagulation status between time points (p > 0.05). There was 1 case of bleeding at the dialysis catheter fixation site (1.82%) and 2 cases of bleeding at the skin graft lesion requiring hemostatic treatment (3.62%). Conclusion: There were no differences in blood potassium levels, blood protein and albumin concentration, and hypocoagulation disorders at all time points.
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Kolesnyk, M. Yu, and Ya M. Mykhailovskyi. "Efficacy and safety of warfarin therapy in patients with atrial fibrillation using genotype-guided dosing method." Zaporozhye Medical Journal 24, no. 4 (2022): 390–95. http://dx.doi.org/10.14739/2310-1210.2022.4.256945.
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The aim. To evaluate the efficacy and safety of warfarin (WF) therapy in patients with atrial fibrillation (AF) using pharmacogenetic dosing method at an anticoagulant monitoring office according to the results of a one-year prospective follow-up. Materials and methods. The study involved 110 patients with AF (mean age 68.72 ± 0.79; men – 57, women – 53). By the method of stratified randomization, the patients with AF were divided into two groups: the main group – 50 patients with AF and genotype-guided dosing method, the control group – 60 patients with AF and clinical dosing method. The outcomes were examined after the one-year follow-up: excessive hypocoagulation episodes (INR > 4) and bleeding. CYP2C9, CYP4F2, VKORC1 gene polymorphisms were determined using multiplex real time polymerase chain reaction; INR was controlled monthly; CHA2DS2-VASC, HAS-BLED, SAMe-TT2R2 scale scores were evaluated; TTR was calculated using the Rosendaal method. Results. The distribution of CYP2C9, CYP4F2, VKORC1 genotypes in the main and control groups were in accordance with the Hardy–Weinberg equilibrium. In patients with AF and genotype-guided dosing, the frequency and risk of excessive hypocoagulation episodes (χ2 = 5.11; P < 0.05; RR = 0.50 (CI 0.27; 0.94)) and bleeding (χ2 = 9.57; P < 0.05; RR = 0.41 (CI 0.22; 0.77)) were significantly lower. However, the groups did not differ in TTR. The validity of genetic-guided dosing was confirmed by the comparability of the medians and the direct correlation between the calculated and therapeutic WF doses (r = +0.57; P < 0.05). There were no relationships between TTR, excessive hypocoagulation episodes, hemorrhagic complications and clinical and genetic factors in the main group. Conclusions. In patients with AF, the use of genotype-guided dosing method in the anticoagulant monitoring office helped to reduce the frequency and risk of excessive hypocoagulation episodes and bleeding as well as eliminate the influence of endogenous and exogenous factors in the personalized management of patients.
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Efimov, V. S., A. G. Rumyantseva, O. A. Golovleva, and M. Ya Rozkin. "Mechanism of prolonged hypocoagulation following intratracheal injection of heparin." Bulletin of Experimental Biology and Medicine 113, no. 5 (1992): 687–90. http://dx.doi.org/10.1007/bf00783760.
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Vdovin, V. M., I. I. Shakhmatov, and A. P. Momot. "Comparative study of predisposition to thrombosis with administration of known systemic hemostatic agents and fibrin monomer in the experiment." Bulletin of Siberian Medicine 21, no. 4 (2023): 20–28. http://dx.doi.org/10.20538/1682-0363-2022-4-20-28.
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Aim. To compare predisposition to thrombosis caused by administration of known systemic hemostatic agents and fibrin monomer under the conditions of normal coagulation versus drug-induced hypocoagulation in the experiment.Materials and methods. The prothrombotic effect of intravenous (IV) administration of various systemic hemostatic agents was compared in a series of in vivo experiments. These agents included fibrin monomer (FM) (0.25 mg / kg), prothrombin complex concentrate (PCC) (40 IU / kg) or recombinant factor VIIa (rFVIIa) (270 mcg / kg). The studies were conducted under the conditions of hypocoagulation induced by the administration of warfarin (per os at a dose of 0.4–0.5 mg / kg / day for 14 days) or dabigatran etexilate (per os at a single dose of 15–20 mg / kg). Hemostatic system parameters were evaluated using thromboelastometry and calibrated automated thrombography.Results. It was found that PCC reversed anticoagulant effects and led to an overcompensated increase in the density characteristics of the blood clot along with an excessive increase in thrombin generation in the groups of animals with warfarin-induced coagulopathy. The use of PCC and rFVIIa in the groups of animals with dabigatran-induced hypocoagulation also resulted in an increase in blood thrombogenic properties. In the administration of PCC, it was manifested though an increased D-dimer level and in administration of rFVIIa – through an increase in the clot density characteristics. At the same time, replacement of these hemostatic agents with FM did not affect the hemostatic system parameters.Conclusion. FM at a dose of 0.25 mg / kg, as opposed to PCC and rFVIIa, is safer in terms of the risk of thrombosis.
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Baishev, I. M. "Influence of inhibition of contact activation on the stability of hemocoagulation and fibrinolysis factors during storage of donor blood." Kazan medical journal 66, no. 6 (1985): 449–50. http://dx.doi.org/10.17816/kazmj62219.
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Donated blood with a shelf life of more than 1-2 days in some cases can cause hypocoagulation in the recipient due to the presence of a preservative, a decrease in the number of platelets, the activity of factors V, VIII and fibrinogen.
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Galeeva, N. V., and I. E. Kravchenko. "INDICATORS OF HEMOSTASIS IN PATIENTS WITH CHRONIC HEPATITIS C." Epidemiology and Infectious Diseases (Russian Journal) 23, no. 6 (2018): 279–85. http://dx.doi.org/10.18821/1560-9529-2018-23-6-279-285.
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Goal of the study is to reveal the particular features of hemostasis in patients with chronic hepatitis C in dynamics of natural course of disease. Materials and methods. The indices of hemostasis in 535 patients with chronic hepatitis C were assessed by the number of platelets, degree of their aggregation with the use of inductor of adenosine triphosphate and without it (spontaneous aggregation of platelets). Coagulative hemostasis was analyzed by the activated partial thromboplastin time, antitrombin III, prothrombin ratio, prothrombin time, fibrinogen concentration in plasma and international normalized ratio. Based on the number of Tr, typical for the disseminated intravascular coagulation syndrome, conditionally the patients were divided into 3 groups: I group - hypercoagulability; II - transient phase between hyper and hypocoagulation and III- hypocoagulation, which also included patients with liver cirrhosis. Results and discussion. Independent on the phase of disseminated intravascular coagulation syndrome, increase of aggregation of Tr with the growth of maximal amplitude was observed. The main part of studied indices of coagulative hemostasis indicated at the condition of hypocoagulation in patients with chronic hepatitis C - this is significant increase of activated partial thromboplastin time, prothrombin time, international normalized ratio and decrease of fibrinogen concentration in the studied groups by the phases of disseminated intravascular coagulation syndrome. Value of antitrombin III changed oppositely, it decreased, so that plasma hemostasis tends to the hypercoagulation. Conclusion. Under the chronic hepatitis C all phases of disseminated intravascular coagulation syndrome were observed with the disorder of thrombocytic coagulative hemostasis. There was followed up multidirectional change of hemostasis which obtained in the most cases character of delitescent course of disseminated intravascular coagulation syndrome.
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Galeeva, N. V., and I. E. Kravchenko. "INDICATORS OF HEMOSTASIS IN PATIENTS WITH CHRONIC HEPATITIS C." Epidemiology and Infectious Diseases (Russian Journal) 23, no. 6 (2018): 279–85. http://dx.doi.org/10.18821/1560-9529-2019-23-6-279-285.
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Goal of the study is to reveal the particular features of hemostasis in patients with chronic hepatitis C in dynamics of natural course of disease. Materials and methods. The indices of hemostasis in 535 patients with chronic hepatitis C were assessed by the number of platelets, degree of their aggregation with the use of inductor of adenosine triphosphate and without it (spontaneous aggregation of platelets). Coagulative hemostasis was analyzed by the activated partial thromboplastin time, antitrombin III, prothrombin ratio, prothrombin time, fibrinogen concentration in plasma and international normalized ratio. Based on the number of Tr, typical for the disseminated intravascular coagulation syndrome, conditionally the patients were divided into 3 groups: I group - hypercoagulability; II - transient phase between hyper and hypocoagulation and III- hypocoagulation, which also included patients with liver cirrhosis. Results and discussion. Independent on the phase of disseminated intravascular coagulation syndrome, increase of aggregation of Tr with the growth of maximal amplitude was observed. The main part of studied indices of coagulative hemostasis indicated at the condition of hypocoagulation in patients with chronic hepatitis C - this is significant increase of activated partial thromboplastin time, prothrombin time, international normalized ratio and decrease of fibrinogen concentration in the studied groups by the phases of disseminated intravascular coagulation syndrome. Value of antitrombin III changed oppositely, it decreased, so that plasma hemostasis tends to the hypercoagulation. Conclusion. Under the chronic hepatitis C all phases of disseminated intravascular coagulation syndrome were observed with the disorder of thrombocytic coagulative hemostasis. There was followed up multidirectional change of hemostasis which obtained in the most cases character of delitescent course of disseminated intravascular coagulation syndrome.
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GALEEVA, N. V. "Role of platelets as one of the markers of the infectious process activity in patients with chronic hepatitis C with an exacerbation." Practical medicine 18, no. 6 (2020): 143–49. http://dx.doi.org/10.32000/2072-1757-2020-6-143-149.
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The purpose. To determine the role of Tr as one of the prognostic signs of the infectious process activation in case of exacerbation of the natural course of CHC at various periods of infection against the background of functional liver failure. Material and methods. 460 people (244 men and 216 women) were observed, divided into three groups depending on the number of Tr, according to the phases of disseminated intravascular coagulation syndrome (DIC): group I — hypercoagulation: Tr > 350 x 109/l, n = 36; group II — phase of multidirectional shifts: Tr 350–200 x 109/l, n = 148; group III — hypocoagulation: Tr < 200 x 109/l, n = 276, including patients with liver cirrhosis (n = 97) in the CHC outcome. We analyzed the number of Tr and their maximum amplitude (MA) of spontaneous aggregation in patients with an active infectious process, which is manifested clinically by indicators of liver functional tests (alanine aminotransferase, total bilirubin and its direct fraction, gamma-glutamyltranspeptidase, alkaline phosphatase, total protein, albumin) and the degree of fibrosis. Conclusion. The number and function of blood platelets in exacerbation of HCV are closely related not only to inflammation of the liver tissue, but also to the duration of infection, which is reflected in the manifestations of DIC syndrome. The longer the time of infection and the more active the infection process, the more pronounced the phase of hypocoagulation with a low Tr number, signs of cholestasis and fibrosis of the liver tissue. The relationship between the decrease in the number of platelets with impaired liver function tests and the severity of fibrosis is confirmed by the presence of correlations between them. Regardless of the phases of the DIC syndrome, an increase in the MA of spontaneous Tr aggregation is characteristic, especially expressed in the hypocoagulation phase.
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Boldyrev, Sergey Y., Kirill O. Barbukhatty, and Vladimir A. Porhanov. "Surgical Treatment of Acute Type A Aortic Dissection with 18-Litre Bleeding." AORTA 09, no. 01 (2021): 030–32. http://dx.doi.org/10.1055/s-0041-1722897.
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AbstractSurgical treatment of Type-A acute aortic dissection is associated with high mortality and morbidity. One of the reasons is perioperative bleeding, which may lead to worse outcomes. We present a case of successful treatment of a patient with 18-litre perioperative blood loss in DeBakey Type-I acute aortic dissection with drug-induced hypocoagulation and malperfusion of a lower extremity.
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Boldyrev, Sergey Y., Kirill O. Barbukhatty, and Vladimir A. Porhanov. "Surgical Treatment of Acute Type A Aortic Dissection with 18-Litre Bleeding." AORTA 09, no. 01 (2021): 030–32. http://dx.doi.org/10.1055/s-0041-1722897.
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AbstractSurgical treatment of Type-A acute aortic dissection is associated with high mortality and morbidity. One of the reasons is perioperative bleeding, which may lead to worse outcomes. We present a case of successful treatment of a patient with 18-litre perioperative blood loss in DeBakey Type-I acute aortic dissection with drug-induced hypocoagulation and malperfusion of a lower extremity.
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Gorodin, V. N., D. L. Moysova, and A. D. Surkova. "The results of hemostasis assessment using thromboelastography in patients with COVID-19." Journal Infectology 15, no. 3 (2023): 44–50. http://dx.doi.org/10.22625/2072-6732-2023-15-3-44-50.
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All currently existing studies of the hemostasis system in COVID-19 using thromboelastography (TEG) were performed on the delta strain of SARS-CoV-2, while there is no information in the literature on conducting such studies in patients infected with the current omicron strain.Research objective. To determine the state of the hemostasis system in hospitalized patients with COVID-19 (omicron strain) using TEG. To assess the relevance of existing guidelines on anticoagulant therapy.Materials and methods. TEG was performed in 93 hospitalized patients with COVID-19 aged 1 to 88 years, of which 66 patients (group 1) on the first day and 27 patients (group 2) – on the second day. For comparison with the parameters of healthy volunteers, a sample of 30 people was formed. Data analysis was performed using the Statistica, version 12 (StatSoft, USA). To compare the independent variable in more than two samples, a multivariate ANOVA analysis of variance was performed with the calculation of the Kruskal-Wallis test. To assess the relationships between continuous variables, the Spearman direct linear correlation coefficient (r) was determined.Results. 53% of patients had hypocoagulation, 31% had normocoagulation, and 16% had hypercoagulation. Elderly patients (61 [26–72]) more often have developed hypocoagulation. Young patients (24.5 [7–37]) more often have developed hypercoagulation. Routine methods for assessing hemostasis did not reflect its true state. Higher levels of fibrinogen (4.5 [5.8–4] g/l) and D-dimer (1.28 [0.5–2.77] µg/ ml) were observed in patients from the group with normocoagulation. Was revealed a statistical tendency towards an increase in the level of amylase when there was an increase in the coagulation properties of the blood.Conclusion. With the current course of COVID-19 and early admission of non-severe patients to the hospital, normocoagulation and hypocoagulation predominate. Elderly and senile patients are not recommended to prescribe anticoagulants without TEG. It is necessary to specify the recommendations for prescribing anticoagulants to hospitalized patients. For the diagnosis of hemostasis disorders expand application of TEG.
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Grigorjeva, M. E., T. Y. Obergan, L. A. Lyapina, and T. A. Shubina. "Restoration of Normal Blood Coagulation by Chitosan when Modeling Hypocoagulation with Aspirin." Biology Bulletin Reviews 14, no. 6 (2024): 788–94. http://dx.doi.org/10.1134/s2079086424600516.
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Orudzheva, Saida A., Anton N. Kudryavtsev, Valentina S. Demidova, et al. "Anticoagulant therapy in a hemodialysis patient at high risk of thrombotic and hemorrhagic complications. Case report." Consilium Medicum 25, no. 1 (2023): 39–45. http://dx.doi.org/10.26442/20751753.2023.1.201951.
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An attempt to preserve the knee joint in a patient on hemodialysis with stage IV lower limb ischemia with a high risk of thrombotic and hemorrhagic complications is presented. Multifocal atherosclerosis and extensive occlusion of the arteries of the lower leg ruled out the technical possibility of revascularization. The patient refused the proposed hip amputation. An attempt was made to perform amputation at the level of the lower leg. Required therapy aimed at the treatment and prevention of thrombotic complications, and optimization of microcirculation in the ischemic limb. For this purpose, a prolonged blockade of the sciatic and femoral nerves, combined anticoagulant therapy, and treatment with alprostadil were performed. Therapy with antithrombotic and vasoactive drugs was not effective and was complicated by the state of persistent hypocoagulation with an episode of bleeding. Amputation of the limb at the level of the thigh was performed according to vital indications after correction of hypocoagulation. The lack of clinical recommendations on anticoagulant therapy for critical lower limb ischemia in patients with stage 5 chronic kidney disease requires an individual approach to the choice of antithrombotic drugs and their doses, monitoring the state of blood coagulation using an integral method for assessing the hemostasis system thromboelastography.
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Bocharov, R. V., M. N. Bocharova, A. L. Solnyshko, and V. V. Udut. "Diagnosis and correction of disorders of blood aggregate statesin children with burning injury." Bulletin of Siberian Medicine 6, no. 4 (2007): 13–16. http://dx.doi.org/10.20538/1682-0363-2007-4-13-16.
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To reveal the character and dynamics of changes in the aggregate state of blood in children with burning injury and to choose the correction method, 200 children in burn shock were investigated. Hemostasis abnormalities were studied with aт ARP-01 analyzer (Mednord, Tomsk). A tactics for anticoagulation therapy has been chosen. A positive effect was observed from combination of programmed hypocoagulation and the method of reinfusion of autocellular mass after its antibiotic incubation
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Moskalenko, S. V., I. I. Shakhmatov, I. V. Kovalev, K. I. Shakhmatova, and V. M. Vdovin. "Reaction of the hemostatic system in response to hypercapnic hypoxia of maximum intensity depending on different types of preconditioning." Kazan medical journal 100, no. 4 (2019): 642–49. http://dx.doi.org/10.17816/kmj2019-642.
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Aim. To study the adaptation reactions of the hemostasis system to hypercapnic hypoxia of maximum intensity in rats subjected to preliminary multiple exposure to ethylmethylhydroxypyridine succinate and hypercapnic hypoxia of submaximal intensity.
 Methods. In the experiment, Wistar male rats (80 individuals) were used. Training cycles: 30-fold daily exposure to hypercapnic hypoxia of submaximal intensity (20 minutes — 9.0±0.5% O2, 7.0±0.5% CO2); administration of ethylmethylhydroxypyridine succinate (50 mg/kg) to animals for 30 days; combined effects of the two described modes. Tested experimental exposure was simulated as a single hypercapnic hypoxia of maximum intensity (20 minutes — 5.0±0.5% O2, 5.0±0.5% CO2) at the end of each of three 30-day training cycles.
 Results. Preliminary 30-day exposure to both isolated hypercapnic hypoxia of submaximal intensity and combined exposure to ethylmethylhydroxypyridine succinate contributes to hypocoagulation shift in the hemostasis system and reduces the level of the markers of pre-thrombotic state in response to a single hypercapnic hypoxia of maximum intensity. The state of the hemostasis system after 30-day cycle of isolated use of an antihypoxant is characterized by the inhibition of the vascular-platelet system of the hemostasis system and preserved hypercoagulation shifts in its plasma unit. The obtained results suggest that both preliminary isolated effect of hypercapnic hypoxia of submaximal intensity and the combined effect of hypercapnic hypoxia and ethylmethylhydroxypyridine succinate increase the resistance of the hemostasis system in experimental animals to acute hypercapnic hypoxia of maximum intensity compared to rats of the control group. This was confirmed by the inhibition of the vascular-platelet system, hypocoagulation in the plasma unit, decrease in the level of thrombotic readiness markers and increase in the anticoagulant activity of the blood system compared to the control. At the same time, isolated course administration of ethylmethylhydroxypyridine succinate did not cause the same amount of adaptive changes to maximum intensity hypercapnic hypoxia, since only platelet suppression of the hemostasis and hypocoagulation via the internal coagulation pathway were registered.
 Conclusion. Isolated exposure of hypercapnic hypoxia of submaximal intensity and its combined exposure with ethylmethylhydroxypyridine succinate increase the resistance of the hemostasis system to acute hypercapnic hypoxia of maximum intensity; isolated course administration of ethylmethylhydroxypyridine succinate does not cause the same amount of adaptive changes.
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Moskalenko, S. V., I. I. Shakhmatov, I. V. Kovalev, K. I. Shakhmatova, and V. M. Vdovin. "Reaction of the hemostatic system in response to hypercapnic hypoxia of maximum intensity depending on different types of preconditioning." Kazan medical journal 100, no. 4 (2019): 642–49. http://dx.doi.org/10.17816/10.17816/kmj2019-642.
Full textAbstract:
Aim. To study the adaptation reactions of the hemostasis system to hypercapnic hypoxia of maximum intensity in rats subjected to preliminary multiple exposure to ethylmethylhydroxypyridine succinate and hypercapnic hypoxia of submaximal intensity.
 Methods. In the experiment, Wistar male rats (80 individuals) were used. Training cycles: 30-fold daily exposure to hypercapnic hypoxia of submaximal intensity (20 minutes — 9.0±0.5% O2, 7.0±0.5% CO2); administration of ethylmethylhydroxypyridine succinate (50 mg/kg) to animals for 30 days; combined effects of the two described modes. Tested experimental exposure was simulated as a single hypercapnic hypoxia of maximum intensity (20 minutes — 5.0±0.5% O2, 5.0±0.5% CO2) at the end of each of three 30-day training cycles.
 Results. Preliminary 30-day exposure to both isolated hypercapnic hypoxia of submaximal intensity and combined exposure to ethylmethylhydroxypyridine succinate contributes to hypocoagulation shift in the hemostasis system and reduces the level of the markers of pre-thrombotic state in response to a single hypercapnic hypoxia of maximum intensity. The state of the hemostasis system after 30-day cycle of isolated use of an antihypoxant is characterized by the inhibition of the vascular-platelet system of the hemostasis system and preserved hypercoagulation shifts in its plasma unit. The obtained results suggest that both preliminary isolated effect of hypercapnic hypoxia of submaximal intensity and the combined effect of hypercapnic hypoxia and ethylmethylhydroxypyridine succinate increase the resistance of the hemostasis system in experimental animals to acute hypercapnic hypoxia of maximum intensity compared to rats of the control group. This was confirmed by the inhibition of the vascular-platelet system, hypocoagulation in the plasma unit, decrease in the level of thrombotic readiness markers and increase in the anticoagulant activity of the blood system compared to the control. At the same time, isolated course administration of ethylmethylhydroxypyridine succinate did not cause the same amount of adaptive changes to maximum intensity hypercapnic hypoxia, since only platelet suppression of the hemostasis and hypocoagulation via the internal coagulation pathway were registered.
 Conclusion. Isolated exposure of hypercapnic hypoxia of submaximal intensity and its combined exposure with ethylmethylhydroxypyridine succinate increase the resistance of the hemostasis system to acute hypercapnic hypoxia of maximum intensity; isolated course administration of ethylmethylhydroxypyridine succinate does not cause the same amount of adaptive changes.
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Markova, M. M., O. S. Polunina, D. G. Tarasov, O. V. Tsverkunova, and E. A. Polunina. "Analysis of survival and timing of non-lethal complications after mitral valve replacement with mechanical prostheses." Medical alphabet, no. 17 (September 7, 2022): 19–22. http://dx.doi.org/10.33667/2078-5631-2022-17-19-22.
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The aim of the study. To study the structure of lethal and non-lethal complications with an analysis of survival and the likelihood of non-lethal complications after mitral valve (MV) replacement with bicuspid mechanical prostheses over a five-year period. Materials and methods. The data of 260 patients who were treated in the period of 2012–2014 were analyzed a surgical intervention was performed – isolated MV prosthetics with mechanical bivalve prostheses. Among the patients, there were 84 (32.3 %) men and 176 (67.7 %) women. The median age was 51.0 [44.0–55.5] years. Statistical analysis was carried out using IBM SPSS Statistics 26.0 (USA). Results of the study and conclusions. According to the results of the five-year survival after MV prosthetics with mechanical prostheses, it was 86.6 %. At the same time, acute cardiovascular diseases (myocardial infarction, cardiac arrhythmias) were the leading cause of death. Among non-lethal thromboembolic complications, acute cerebrovascular accident prevailed, it developed in 65.3 %. Among nonlethal hypocoagulation complications, nosebleeds were most often recorded – in 40.5 % of patients. The probability of developing non-lethal thromboembolic complications by the fifth year is 20.0 % vs 18.5 % in the first six months after prosthetics with mechanical prostheses. And the probability of developing non-lethal hypocoagulation complications by the fifth year is 26.8 % vs 6.1 % in the first six months after prosthetics with mechanical prostheses.
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Delano, Matthew J., Sandro B. Rizoli, Shawn G. Rhind, et al. "Prehospital Resuscitation of Traumatic Hemorrhagic Shock with Hypertonic Solutions Worsens Hypocoagulation and Hyperfibrinolysis." Shock 44, no. 1 (2015): 25–31. http://dx.doi.org/10.1097/shk.0000000000000368.
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Kirgizov, I. V., A. M. Sukhorukov, V. A. Dudarev, and A. A. Istomin. "Hemostasis in Children With Dysbacteriosis in Chronic Constipation." Clinical and Applied Thrombosis/Hemostasis 7, no. 4 (2001): 335–38. http://dx.doi.org/10.1177/107602960100700416.
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The purpose of the study was to investigate hemostasis in children with dysbacteriosis disturbance in chronic constipation. The disturbance of factors in the inner mechanism of blood coagulation (VII, IX, XI, XII) in compensated chronic constipation was defined based on the reduction in colon bacillus levels. We observed hypocoagulation caused by the reduced activity of the prothrombin complex factors, disaggregate thrombocytopathy, and endotheliosis with fibrinolysis inhibition in subcompensated chronic colostasis with continuous reduction of colon bacillus levels and pathogenic microflora appearance. In decompensated colostasis there was an increase in pathogenic microorganisms and a continuous reduction of colon bacillus levels. In hemostasis there was a factor deficiency in inner (XII, XI, IX, VIII) and outer (II, V, VII, X) blood coagulation mechanisms. Fibrinolysis inhibition, endotheliosis development with thrombocyte aggregation, and microthrombosis formation were determined. Thus, in children with chronic constipation, there was a marked reduction in the amount of colon bacillus, which led to the reproduction of pathogenic bacteria. We also observed chronometric hypocoagulation with the inner (XII, XI, IX. VIII) and outer (II, V, VII, X) mechanisms of blood coagulation, at the base of which there is the deficiency of vitamin K-dependent factors (II, VII, IX, X) and a slightly marked disturbance in the final stage of coagulation. In thrombocyte vascular hemostasis, thrombocytopathy was observed with increased adenosine-5-diphosphate aggregation and the inhibition of the inner mechanism with fibrinolysis and endotheliosis.
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Galeeva, N. V., and I. Kh Valeeva. "Activity an enzyme 5`-nucleotidase in patients with chronic hepatitis C." Terapevticheskii arkhiv 91, no. 11 (2019): 45–48. http://dx.doi.org/10.26442/00403660.2019.11.000244.
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Aim of the study. To determine the activity of enzyme 5`-nucleotidase depending on the of disseminated intravascular coagulation syndrome phases and duration of infection period in patients with chronic hepatitis C. Materials and methods. 166 patients (92 men, 74 women) with chronic hepatitis C were under observation. Conditionally, all patients were devided into 3 groups, based on the number of Tr, according to the phases of hemostasis: I group - hypercoagulation with number Tr>350×109/l; II - transient phase - Tr from 350 to 200×109/l and III - hypocoagulation - Tr
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Marjanovic, Marjan. "Application of thrombin powder after tooth extraction in patients receiving anticoagulant therapy." Vojnosanitetski pregled 59, no. 4 (2002): 389–92. http://dx.doi.org/10.2298/vsp0204389m.
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Patients with extreme hypocoagulation, which occurs either as an effect of some diseases with coagulation deficiency or because of the anticoagulant therapy (ACT), are a risk group for oral surgery. In the last decades decision to change or interrupt ACT before and after the procedure was abandoned and more often local hemostasis was being achieved by combining chemical and biological substances. The success of the surgical hemostasis and thrombin powder combination was tested on the group of 20 patients with ACT. The results were satisfactory despite thrombin powder solubility in the moist oral environment.
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Osipenko, D. V. "Guided hypocoagulation as a component of anesthesia support at operative interventions in vascular surgery." Novosti Khirurgii 21, no. 1 (2013): 78–83. http://dx.doi.org/10.18484/2305-0047.2013.1.78.
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Enikeeva, D. A., I. K. Sarycheva, E. �. Zhukova, R. P. Evstigneeva, and V. I. Tonkonozhenko. "Testing of the activity of water-soluble derivatives of phytomenadione in experimental hypocoagulation. II." Pharmaceutical Chemistry Journal 19, no. 2 (1985): 113–16. http://dx.doi.org/10.1007/bf00771775.
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Peretyatko, Ilya S., and Elena V. Mozgovaya. "Evaluation of the diagnostic possibility of hemorrhagic risk in pregnant women with severe preeclampsia by rotational thromboelastography." Journal of obstetrics and women's diseases 70, no. 2 (2021): 37–44. http://dx.doi.org/10.17816/jowd71083.
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AIM: The aim of this study was to determine the risk of hemorrhagic complications in pregnant women with severe preeclampsia using rotational thromboelastometry (ROTEM) in two screening tests EXTEM and INTEM.
 MATERIALS AND METHODS: We examined 30 pregnant women with severe preeclampsia, who were observed in the intensive care unit, the Department of Obstetrics and Perinatology, the Research Institute of Obstetrics, Gynecology, and Reproductology named after D.O. Ott, Saint Petersburg. The control group consisted of 10 patients with normal pregnancy, delivered by caesarean section for reasons not related to obstetric complications.
 RESULTS: When interpreting the ROTEM results, the reference intervals for pregnant women in the third trimester were used, as determined in the study by J. Lee et al. (2019). According to the analysis of thromboelastograms of pregnant women with severe preeclampsia, 9 (30%) of them had a tendency towards hypocoagulation. Of these, 3 thromboelastograms had deviations via the intrinsic coagulation pathway (in the INTEM tests), 3 thromboelastograms via the extrinsic coagulation pathway (in the EXTEM tests), and the rest combined both options. Two patients with severe preeclampsia developed a complication in the form of HELLP syndrome, and the phenomena of hypocoagulation, according to the results of ROTEM performed before delivery, were observed in only one patient. A comparative analysis of ROTEM parameters among pregnant women with severe preeclampsia and normal pregnancy did not reveal statistically significant differences.
 CONCLUSIONS: The use of the ROTEM method with the main screening tests (EXTEM and INTEM) did not show diagnostic value in assessing the risk of hemorrhagic complications of severe preeclampsia.
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Sokolov, D. A., Pavel A. Lyuboshevskiy, and A. N. Ganert. "INFLUENCE OF CYTOCHROME P-450 GENETIC POLYMORPHISMS ON THE MAIN AND SIDE EFFECTS OF TRAMADOL IN THE POSTOPERATIVE PERIOD." Regional Anesthesia and Acute Pain Management 11, no. 4 (2017): 240–46. http://dx.doi.org/10.18821/1993-6508-2017-11-4-240-246.
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One of the approaches to increasing the effectiveness and safety of postoperative analgesia can be its personification. The goal of the study was to evaluate the efficacy of tramadol analgesia depending on the polymorphisms of the CYP2D6 gene, the cytochrome P-450 isoenzyme, involved in drug biotransformation into the active metabolite. 96 patients with elective endoscopic gynecology procedures were examined. Polymorphisms G1846A and C100T, which reduce the activity of the isoenzyme CYP2D6, were detected, and the intensity of postoperative pain, the autonomic nervous system state by cardiointervalography and hemostasis using rotational thromboelastometry were evaluated. Polymorphisms were detected in 29 (30.2%) patients, united in the 1-st group. The second group consisted of 67 patients without gene polymorphisms. Patients with polymorphisms have a higher pain scores; the frequency of postoperative nausea and vomiting, on the contrary, was significantly lower. According to cardiointervalography, sympathicotonia was observed in Group 1 patients after surgery, while in Group 2 patients the indices did not change significantly compared to baseline. The parameters of hemostasis in patients of the 2nd group were characterized by moderate hypercoagulability (shortening of clotting time and clot formation time), whereas in the firsts group, relative hypocoagulation (decrease in α angle, and clot firmness) was noted. Conclusion. In female carriers of G1846A and C100T polymorphisms of the CYP2D6 gene, the effectiveness of post-operative analgesia based on tramadol is reduced. They have a lower incidence of postoperative nausea and vomiting, and moderate hypocoagulation. Probably, these phenomena are associated with a change in the ratio between the drug and its active metabolite - O-desmethyltramadol.
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Wang, Zhengwei, Jing Li, Qingwei Cao, Lei Wang, Fengzhi Shan, and Houyi Zhang. "Comparison Between Thromboelastography and Conventional Coagulation Tests in Surgical Patients With Localized Prostate Cancer." Clinical and Applied Thrombosis/Hemostasis 24, no. 5 (2017): 755–63. http://dx.doi.org/10.1177/1076029617724229.
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We aimed to examine hypercoagulable and hypocoagulable conditions in patients with prostate cancer using thromboelastography (TEG) and correlate TEG parameters with conventional coagulation test. The t test was used for comparing TEG parameters and routine coagulation results. Spearman rank-order correlation was used to describe the relationship of TEG and conventional tests. Sensitivity, specificity, positive predictive values, and negative predictive values were determined for bleeding and thrombosis. Totally, 20 patients had active bleeding postoperatively, 16 of whom showed hypocoagulation on TEG test and 9 of whom showed hypocoagulation by routine coagulation test ( P = .024). Overall, 60 patients did not have active bleeding postoperatively, 51 of whom showed hypercoagulation detected by TEG test and 42 of whom showed hypercoagulation found by routine coagulation test ( P = .040). Remarkably, patients had a little higher fibrinogen (FIB) compared to controls. There was no statistical difference in any of the conventional coagulation indexes between the groups. Correlation analysis showed that reaction time (R) and coagulation time (K) were positively correlated with the prothrombin time–international normalized ratio (PT-INR) and negatively correlated with FIB ( P < .001). Contrarily, α-angle and maximum amplitude (MA) were negatively correlated with PT-INR but positively correlated with FIB. Significantly, MA showed the strongest correlation with FIB and R exhibited the strongest correlation with PT-INR. Sensitivity and specificity for bleeding and thrombosis in TEG were higher than those in conventional coagulation test. Accordingly, TEG might be superior in evaluating hypercoagulation and detecting the risk of bleeding in patients with prostate cancer.
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Ruzibayev, R. Yu, P. Yu Ruzmatov, and D. A. Umarov. "Morphological Assessment Of Wounds Healing In The Region Of Anal Canal In Rats On The Background Of Medicamental Hypocoagulation." American Journal of Applied sciences 03, no. 09 (2021): 5–15. http://dx.doi.org/10.37547/tajas/volume03issue09-02.
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Purpose of the study: to conduct a morphological study of experimental material to assess the features of wound healing in the anal sphincter area when using the domestic drug “Heprocel” as a hemostatic agent. Material and methods. The study was carried out in the Department of experimental surgery and the department of pathological anatomy of the Republican Specialized Scientific and Practical Medical Center for Surgery named after Academician V. Vakhidov. The state of experimental models of wounds with the application of a hemostatic agent in the form of a gel was studied. The experiments were carried out on 72 white male rats weighing 210-250 g. Two series of 36 animals each were produced. All animals were divided into groups: norm - experiment in the absence of drug hypocoagulation; control - an experiment with intravenous heparin to achieve drug hypocoagulation; experience - an experiment with intravenous administration of heparin to achieve drug hypocoagulation using an application on a model of a skin wound and a dissected anal sphincter of the hemostatic agent "Heprocel". Results. Morphological differences in the process of wound healing were most pronounced after 3 days of the study. In the control group of animals with hemostasis using an electrocoagulator, necrotic and exudative processes of inflammation in the stratified squamous epithelium and mucous membrane of the glands in the anal region were evident. In the experimental group, on the 3-5th day of the experiment, the proliferative process of inflammation predominated morphologically. A special feature is that the hemostatic gel is absorbed into the wound, forming a thin uniform layer. On the 10th day of the experiment, the above difference became more obvious. In the control group, chaotic squamous epithelial cells and fibroblasts were formed. The fibrin-necrotic layer is preserved. Focal infiltration of macrophages-lymphocytes was observed. In the experimental group, the intestinal layers began to change. In the area of the surgical incision, the hemostatic layer is preserved; in this area, the growth of thin fibrous connective tissue is observed. Differentiation and transformation of cells led to the regeneration of the epithelial layer and parakeratosis of the flat cell. Signs of complete remodeling were evident over a long period of time, such as 14 days. Conclusion. The use of a hemostatic agent in the form of a gel provides not only an increase in the processes of local hemostasis, but a decrease in the activity of inflammatory reactions and infection, as well as the risk of developing post-traumatic cicatricial deformity of the anus.
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Dzhantaeva, G., and G. Kudaybergenova. "Age Changes in the Indicators of Plasma Hemostasis in Tubercular Infection at the Background of Chemical Drugs." Bulletin of Science and Practice 5, no. 5 (2019): 78–82. http://dx.doi.org/10.33619/2414-2948/42/10.
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A study of plasma hemostasis in 49 patients suffering from bone tuberculosis before and after chemotherapy has been conducted. It was established that in the group of patients older than 50 years after treatment with chemotherapy drugs, there is a moderate hypocoagulation shift in the hemostasis system, expressed in a decrease in the prothrombin index, a decrease in the level of fibrinogen, an increase in the prothrombin time. The aim of the study was to study the indicators of the hemostatic system in patients of different age groups with tuberculous infection of the bone apparatus before and after chemotherapy.
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Grigimalsky, E. V., A. I. Garga, A. V. Tarasov, I. N. Dovgiy, and N. N. Budnyk. "An anesthesiologist’s view of problems in HIV-positive patients." Perioperaciina Medicina 1, no. 1 (2018): 66–69. http://dx.doi.org/10.31636/prmd.v1i1.9.
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Currently, HIV infection is becoming epidemic. More than 42% of HIV-infected people in the world are women of childbearing age. With the onset of antiretroviral therapy, chemoprophylaxis during pregnancy, and planned cesarean section, the risk of perinatal HIV transmission decreases to 1–2%. However, various side effects such as anemia, neutropenia, thrombocytopenia, fatty liver dystrophy, toxic hepatitis, acute pancreatitis, increased serum transaminases, changes in biochemical parameters of liver function, impaired glucose tolerance, and hypocoagulation may occur in the context of antiretroviral therapy. This poses to the anesthesiologist a number of new tasks to ensure patient safety during the perioperative period.
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Dzhantaeva, G., and G. Kudaybergenova. "Age Changes in the Indicators of Plasma Hemostasis in Tubercular Infection at the Background of Chemical Drugs." Bulletin of Science and Practice 5, no. 5 (2019): 78–82. https://doi.org/10.33619/2414-2948/42/10.
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A study of plasma hemostasis in 49 patients suffering from bone tuberculosis before and after chemotherapy has been conducted. It was established that in the group of patients older than 50 years after treatment with chemotherapy drugs, there is a moderate hypocoagulation shift in the hemostasis system, expressed in a decrease in the prothrombin index, a decrease in the level of fibrinogen, an increase in the prothrombin time. The aim of the study was to study the indicators of the hemostatic system in patients of different age groups with tuberculous infection of the bone apparatus before and after chemotherapy.
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Nielsen, Vance G., S. Nini Malayaman, Jack B. Cohen, and Joshua M. Persaud. "Carbon Monoxide Releasing Molecule-2 Improves Protamine-Mediated Hypocoagulation/Hyperfibrinolysis in Human Plasma In Vitro." Journal of Surgical Research 173, no. 2 (2012): 232–39. http://dx.doi.org/10.1016/j.jss.2010.09.007.
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Popovich, Ya M., and V. V. Rusin. "COAGULOGRAM INDICES IN PATIENTS WITH DEEP VEIN TROMBOSIS, DEPENDING ON THE METHOD OF TREATMENT." Kharkiv Surgical School, no. 2 (April 20, 2020): 81–85. http://dx.doi.org/10.37699/2308-7005.2.2020.16.
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Summary. Despite a satisfactory number of research which dedicated on coagulogram changes in patients with DVT, they are rarely used in clinical practice for the diagnosis of thrombosis, more often for the correction of anticoagulant therapy.
 The aim of research. Estimate the changes of coagulogram indices in patients with deep vein thrombosis, depending on the type of treatment performed.
 Materials and methods. Has been performed the quantitative estimation of coagulogram indices in 721 patients with deep vein thrombosis. Depending on the treatment method, the patients were divided into two groups: І – 382 (53 %) patients, which performed the surgical treatment with the following prescription the anticoagulant therapy; ІІ – 339 (47 %) patients, which performed only the anticoagulant therapy.
 Results. Has been observed more expression of hypocoagulation in patients of I group for the essesment the most of the coagulogram indices: the level of D-dimer was 14.1 % lower than in II group, the average concentration of thrombocyte was 7.8 %, the prothrombin index was 7.1 %, the international normalized ratio by 3.8 %, the level of hematocrit by 2.4 %, platelet count by 1.9 % lower than in patients ІІ group. More expression the prolongation of activated thromboplastin time, activated recalcification time and prothrombin time for 37.9 %, 10.6 % and 4.8 %, respectively, was observed in I group compared with the patients II group. At the same time, the level of fibrinogen in the I group was 9.1 % higher compared with the patients II group.
 Conclusions. Hypocoagulation changes of haemostasis in patients which performed the surgical treatment for deep vein thrombosis, compared to patients with isolated anticoagulant therapy, suggest that mechanical removal of thrombotic masses promotes faster normalization of indices hemostasis.
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Khorkova, N. Yu, T. P. Gizatulina, A. V. Belokurova, and A. V. Mamarina. "The possibilities of monitoring the effectiveness of anticoagulant therapy using a thrombodynamics test in patients with left atrial appendage thrombosis with non-valvular atrial fibrillation: clinical cases." Journal of Arrhythmology 32, no. 2 (2025): 1–7. https://doi.org/10.35336/va-1434.
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Clinical observations of the possibility of using the thrombodynamics test (TD) in comparison with standard hemostasis tests in patients with non-valvular atrial fibrillation (AF) and detected thrombosis of the left atrial appendage against the background constant oral anticoagulants are presented. It has been shown that the transfer from one direct oral anticoagulant (DOACs) to another (with a different mechanism of action), as well as from DOACs to warfarin, can change the state of the blood plasma coagulation system towards both hyper- and hypocoagulation. Unlike standard hemostasis tests, TD can be used to assess the prothrombotic status of a patient with AF and personalized selection of effective anticoagulant therapy.
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Isakova, Jyldyz, Aynura Sayakova, and Gulnara Beishenbieva. "Peculiarities of the menstrual function of adolescent girls, internal migrants from the highland regions of Kyrgyzstan." Heart, Vessels and Transplantation 2, Issue 3 (2018): 70. http://dx.doi.org/10.24969/hvt.2018.71.
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Objective: To study the nature of changes and peculiarities of the menstrual function in adolescent girls, internal migrants from the highland regions of the republic, depending on the length of stay in lowland areas. Methods: Overall 387 migrants from high-altitude girls were examined. The obtained data were compared with those of 280 girls, permanent residents of Bishkek. We examined the residence duration in both highlands and lowlands, the age of the menarche, the length of the menstrual cycle, the number of menstruation days, the frequency and the amount of blood loss before and after moving to lowland conditions. Results: Lengthening of the menstrual cycle and an increase in menstruation days, as well as, a slight increase for blood loss during menstruation were revealed. The change in place of residence also affects the regularity of the menstrual cycle, which may be due to some hypocoagulation state of the hemostasis system in them during de-adaptation to low-mountain conditions. These changes are particularly pronounced when the term of residence in the lowlands is up to 1 year. Conclusion: Thus, the study of peculiarities of menstrual function and tendencies of its changes in response to the move from highland region to the lowland region for adolescent girls showed that there is a slight increase of a menstrual cycle and an increase in the menstruation itself. In addition, there was an increase in the amount of blood loss during menstruation. The change of place of residence influenced the regularity of the menstrual cycle as well, which may be due to some hypocoagulation state of the hemostasis system in them during de-adaptation to low-mountain conditions. These changes are especially expressed for girls who just move in to the lowland region and being there for up to a year.
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Kostrova, Olga Yu, Irina S. Stomenskaya, Natalya Yu Timofeeva, et al. "THROMBOELASTOGRAPHY IN ASSESSING THE HEMOSTATIC SYSTEM IN INTENSIVE CARE PATIENTS." Acta medica Eurasica, no. 3 (September 30, 2021): 18–25. http://dx.doi.org/10.47026/2413-4864-2021-3-18-25.
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The results of thromboelastography and standard coagulogram were analyzed in 35 patients aged from 18 to 86 who were treated in the resuscitation and intensive care unit. The majority of patients (34%) were hospitalized in the department with multisystem and concomitant injuries. The remaining patients were taken to the medical institution with different diagnoses (urolithiasis, liver cirrhosis, pancreatic lesion of various types, poisoning, peptic ulcer, sepsis). The data of coagulogram and thromboelastography at different stages of treatment were compared. In patients with the development of traumatic shock, the coagulogram parameters were changed to varying degrees depending on the stage of shock. At the first stage of shock, only an increase in soluble fibrin-monomer complexes by almost 2 times and a slight increase in fibrinogen dynamics were noted in the analysis. In a patient with stage 3 traumatic shock, the coagulogram parameters were within the normal range, but according to thromboelastography (EXTEM and FIBTEM tests), hypocoagulation due to the platelet link was noted. Only the coagulogram was evaluated in dynamics, hypocoagulation was noted in the indicators of internal and external hemostasis pathways: lengthening of the activated partial thromboplastin time, a decrease in the prothrombin index and an increase in the international normalized ratio, an increase in fibrinogen A and soluble fibrin-monomer complexes. In the group of male patients with closed craniocerebral trauma, an increase in soluble fibrin-monomer complexes in the coagulogram was always combined with changes in the FIBTEM test during thromboelastography. In most patients, no changes in the classical coagulogram tests immediately after the injury are noted. At this, thromboelastography makes it possible to make up for this deficiency at an earlier time, which indicates a high sensitivity of the method.
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Kone, Dr Mama, NAGALO Ousmane, OUSSOU N’Guessan Jean-Baptiste, and YAPO Angoué Paul. "Hemostatic potential of total aqueous extract of Sacoglottis gabonensis (Baille) Urban (Humiriaceae) stem bark in Wistar rats pretreated with warfarin." SDRP Journal of Cellular and Molecular Physiology 4, no. 1 (2022): 211–19. http://dx.doi.org/10.25177/jcmp.4.1.ra.10817.
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Background: Sacoglottis gabonensis is a medicinal plant used in traditional treatment of Buruli ulcer and leprosy in Côte d'Ivoire. A study conducted on the healing potential of this herb on induced wounds showed good results. The objective of this study is to evaluate the hemostatic potential of the total aqueous extract of Sacoglottis gabonensis (TAESg) in rats after a pretreatment with warfarin. Methods: Thus, 42 rats were evenly distributed into seven groups of six rats each. The rats in group 1 did not receive treatment whereas those in groups 2, 3, 4, 5, 6 and 7 pretreated with warfarin received by oral route, distilled water, 100 mg/kg body weight (bw) of Vitamin K1 and doses of 3.5; 17.5; 35 and 350 mg/kg bw of TAESg, respectively. Blood samples were collected from the rats’ retro-orbital sinus before the experiment, after induction the blood hypocoagulation with warfarin and after the treatments with vitamin K or the extract in orderto determine hemostatic parameters such as the prothrombin time, the activated partial thromboplastin time and the International Normalized Ratio, the fibrinogen level, the calcium level and the thrombocyte level. Results: The results showed disturbances in the hemostatic parameters of warfarin-induced hypocoagulability rats. The treatments with TAESg significantly normalized these parameters by reducing the prothrombin time, the activated partial thromboplastin time and the INR and by increasing fibrinogen levels. However, the levels of calcium and thrombocytes which were increased after the administration of warfarin did not experience any significant change after the treatments with TAESg or Vitamin K, depending on the group. Conclusion: TAESg has some hemostatic properties similar to those of vitamin K. Key words: hypocoagulation, hemostatic parameters, rats, Sacoglottis gabonensis.
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Bulatova, I. A., T. P. Shevlyukova, I. L. Gulyaeva, A. A. Sobol, and S. V. Paducheva. "Indicators of the hemostasis system and markers of endothelial damage in patients with steatosis and liver fibrosis." Meditsinskiy sovet = Medical Council, no. 8 (May 25, 2023): 106–12. http://dx.doi.org/10.21518/ms2022-039.
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Introduction. According to the analysis of indicators of the hemostasis system in liver pathology, there are multidirectional data in the literature, which may be associated with the examination of patients with varying degrees of severity and etiology of the process. Aim. The aim of the study was to study the indicators of hemostasis and markers of endothelial damage in patients with non-alcoholic steatosis and liver fibrosis of viral etiology. Materials and methods. A total of 64 people were examined. The first group included 32 patients with non-alcoholic liver steatosis on the background of obesity of 1–2 degrees, with an average age of 46.3 ± 4.3 years (12 men and 20 women). The second group consisted of 22 patients with liver fibrosis on the background of chronic hepatitis C (HCV) with an average age of 36.8 ± 4.7 years (12 men and 10 women). The control group included 10 practically healthy individuals with an average age of 38.9 ± 5.3 years without liver pathology. The number of platelets, platelet aggregation with ADP inducers, collagen and ristocetin, functional activity of Willebrand factor (vWF), coagulation hemostasis and fibrinolysis system, and serum concentration of vascular endothelial growth factor (VEGF) were determined. Statistical processing of the obtained data was carried out using the program “Stat2015”. Results. Induced platelet aggregation in steatosis and liver fibrosis significantly decreased with ADP agonists and collagen against the background of a normal platelet count. In both study groups, signs of endothelial damage with a tendency to increase the functional activity of vWF and VEGF hyperproduction were found. An elongation of thrombin time was also recorded, more significantly in patients with steatosis. Conclusion. Patients with non-alcoholic liver steatosis and liver fibrosis on the background of HCV are characterized by disorders in the vascular-platelet (endothelial damage and thrombocytopathy in the form of platelet hypocoagulation) and coagulation (hypocoagulation) links of hemostasis.
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Pshenisnov, K. V., Yu S. Аleksandrovich, M. A. Udaltsov, et al. "Difficult Diagnosis: A Case of Hemophagocytic Lymphohistocytosis in an Infant." Messenger of ANESTHESIOLOGY AND RESUSCITATION 19, no. 1 (2022): 91–98. http://dx.doi.org/10.21292/2078-5658-2022-19-1-91-98.
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Hemophagocytic lymphohistocytosis is an extremely rare disease requiring early diagnosis and specific treatment.The objective: to demonstrate the clinical case of hemophagocytic lymphohistocytosis in an infant. The course of the disease in a 6-month-old child requiring treatment in the intensive care unit was retrospectively analyzed. The article presents the procedure of differential diagnosis of sepsis and hemophagocytic lymphohistocytosis in children, special attention is paid to the diagnostic criteria, and the clinical and laboratory differences of these diseases are described.Conclusion. The presence of leukopenia, neutropenia, thrombocytopenia, hypoalbuminemia and hypocoagulation in an infant with persistent fever is the basis for a thorough differential diagnosis in order to eliminate severe systemic diseases that manifest as childhood infections and sepsis.
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Vavilova, T. V., L. V. Solovyova, A. B. Bekoeva, et al. "The best practices of the Russian Federation in the organization of anticoagulant therapy in patients with high risk of thromboembolic events." Russian Journal of Cardiology 25, no. 6 (2020): 3945. http://dx.doi.org/10.15829/1560-4071-2020-3945.
Full textAbstract:
Organization of anticoagulant therapy control plays a key role in ensuring the effectiveness and safety of anticoagulant use. Currently, several models of organization are successfully used in the Russian Federation, which cover more than 23000 patients at high risk for thromboembolic events. There are following common features of the models used: the maximum reduction in the time from the moment of international normalized ratio (INR) testing with a quick communication with a patient for the need to adjust the dose, the ability to sort patients depending on the degree of hypocoagulation and the risks of events with the creation of a personalized approach to treatment, the organization of a shared information space and maintaining a register of patients.
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Kropacheva, Ekaterina S. "PHARMACOGENETICS OF ANTITHROMBOTIC DRUGS: STATUS UPDATE ON THE PROBLEM." Atherothrombosis Journal, no. 2 (December 27, 2018): 115–29. http://dx.doi.org/10.21518/2307-1109-2018-2-115-129.
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The review deals with the main trials devoted to the study of genetic markers of individual variability in drug response to antithrombotic agents. The first part describes the studies of the genes encoding the platelet receptor subunits studied in the association of the possible insufficient effect of acetylsalicylic acid, and transporter proteins and allelic variants with reduced CYP450 functional activity, which are associated with insufficient effect on clopidogrel therapy. The second part considers polymorphisms that determine the individual dose and the risk of bleeding due to excessive hypocoagulation in patients taking warfarin. It also presents current data on the study of genetically determined individual reactions to the new inhibitors: P2Y12 inhibitors (prasugrel and ticagrelor) and direct oral anticoagulants.
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Reshetnyak, V. I., I. V. Maev, T. M. Reshetnyak, S. V. Zhuravel, and V. M. Pisarev. "Liver Diseases and the Hemostasis (Rewiew) Part 1. Non-Cholestatic Diseases of the Liver and Hemostasis." General Reanimatology 15, no. 5 (2019): 74–87. http://dx.doi.org/10.15360/1813-9779-2019-5-74-87.
Full textAbstract:
In liver diseases, most commonly in the terminal stage of liver failure, a variety of hemostatic defects affecting almost all parts of the blood coagulation system are developing. This leads to diminishing the capabilities of patients with liver diseases to correctly maintain the hemostatic balance.The severity of hemostatic disorders depends on the nosological form and degree of a liver damage. Depending on the imbalance of the hemostasis system and accumulated clinical/laboratory data, patients with liver diseases can be subdivided into three groups as exhibiting: 1. non-cholestatic liver damage; 2. cholestatic liver damage and 3. liver damage of vascular origin.The first part of the review discusses multiple alterations in the hemostasis system in patients with noncholestatic liver diseases, which are commonly accompanied by hypocoagulation.