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Journal articles on the topic 'Hypoglycaemic potential'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Fabricius, Therese W., Clementine E. M. Verhulst, Peter L. Kristensen, et al. "Hyperinsulinaemic–hypoglycaemic glucose clamps in human research: a systematic review of the literature." Diabetologia 64, no. 4 (2021): 727–36. http://dx.doi.org/10.1007/s00125-020-05361-8.

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Abstract Aims/hypothesis The hyperinsulinaemic–hypoglycaemic glucose clamp technique has been developed and applied to assess effects of and responses to hypoglycaemia under standardised conditions. However, the degree to which the methodology of clamp studies is standardised is unclear. This systematic review examines how hyperinsulinaemic–hypoglycaemic clamps have been performed and elucidates potential important differences. Methods A literature search in PubMed and EMBASE was conducted. Articles in English published between 1980 and 2018, involving adults with or without diabetes, were inc

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Kern, Werner, Andreas Holstein, Christian Moenninghoff, Joachim Kienhöfer, Matthias Riedl, and Bernhard Kulzer. "Self-reported Hypoglycaemic Events in 2 430 Patients with Insulin-treated Diabetes in the German Sub-population of the HAT Study." Experimental and Clinical Endocrinology & Diabetes 125, no. 09 (2017): 592–97. http://dx.doi.org/10.1055/s-0043-112350.

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AbstractData concerning true hypoglycaemic incidence in insulin-treated patients with diabetes in real-world clinical practice are lacking in Germany. The aim of this analysis was to determine the incidence of hypoglycaemia experienced by the German cohort of patients enrolled in the global Hypoglycaemia Assessment Tool (HAT) study. This was a non-interventional, 6-month retrospective and 4-week prospective study using self-assessment questionnaires and patient diaries assessing patients aged ≥18 years in Germany, with type 1 diabetes (T1D) (n=811) or type 2 diabetes (T2D) (n=1 619) treated wi

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3

Jin, Fang-Xin, Yan Wang, Min-Ne Li, Ru-Jiang Li, and Jun-Tang Guo. "Intestinal glucagon-like peptide-1: A new player associated with impaired counterregulatory responses to hypoglycaemia in type 1 diabetic mice." World Journal of Diabetes 15, no. 8 (2024): 1764–77. http://dx.doi.org/10.4239/wjd.v15.i8.1764.

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BACKGROUND Impaired hypoglycaemic counterregulation has emerged as a critical concern for diabetic patients who may be hesitant to medically lower their blood glucose levels due to the fear of potential hypoglycaemic reactions. However, the patho-genesis of hypoglycaemic counterregulation is still unclear. Glucagon-like peptide-1 (GLP-1) and its analogues have been used as adjunctive therapies for type 1 diabetes mellitus (T1DM). The role of GLP-1 in counterregulatory dys-function during hypoglycaemia in patients with T1DM has not been reported. AIM To explore the impact of intestinal GLP-1 on

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Yskout, Marie, Joke Vliebergh, Hakan Bor, et al. "Hypoglycaemia after Initiation of CFTR Modulator Therapy in a Cystic Fibrosis Patient without Diabetes." Case Reports in Endocrinology 2023 (December 23, 2023): 1–4. http://dx.doi.org/10.1155/2023/9769119.

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Introduction. Cystic fibrosis transmembrane regulator (CFTR) modulator therapies improve respiratory function and glycaemic control in patients with cystic fibrosis (CF). The direct effect of CFTR modulator therapies on pancreatic function in patients without preexisting diabetes remains unclear. Case Presentation. An 18-year-old female with CF caused by F508del/F508del mutation, who had no diabetes, developed postprandial hypoglycaemias 6 months after initiation of elexacaftor, tezacaftor, and ivacaftor combination therapy (ETI). Symptoms were persisted after brief discontinuation of ETI, but

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Teale, J. D., W. F. Blum, and V. Marks. "Alleviation of Non-Islet Cell Tumour Hypoglycaemia by Growth Hormone Therapy is Associated with Changes in IGF Binding Protein-3." Annals of Clinical Biochemistry: International Journal of Laboratory Medicine 29, no. 3 (1992): 314–23. http://dx.doi.org/10.1177/000456329202900312.

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The hypoglycaemia caused by non-islet cell tumours is often associated with an increase in plasma insulin-like activity. In many cases there is a relative if not always absolute increase in plasma insulin-like growth factor II (IGF-II). Growth hormone (GH) secretion is almost invariably depressed as is the plasma insulin response to oral glucose. Despite the high concentration of IGFs (i.e. IGF-I and IGF-II) normally found in the plasma of healthy people their potential hypoglycaemic effect is not manifest due to the tightness with which they are bound to specific binding proteins (IGFBPs). Pl

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BJÖRKLUND, Anders O., Ulf K. C. ADAMSON, Per-Eric S. LINS, and L. Magnus R. WESTGREN. "Diminished insulin clearance during late pregnancy in patients with Type I diabetes mellitus." Clinical Science 95, no. 3 (1998): 317–23. http://dx.doi.org/10.1042/cs0950317.

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1.Intensive insulin treatment of patients with Type I diabetes mellitus during pregnancy is associated with a high frequency of serious hypoglycaemic events. A potential change in insulin metabolism during pregnancy may affect both the frequency and the severity of insulin-induced hypoglycaemia. 2.In 10 patients with Type I diabetes, during the third trimester of pregnancy and 5 to 13 months after delivery, hypoglycaemia was induced by the hyperinsulinaemic hypoglycaemic clamp technique. A constant high-dose intravenous insulin infusion was administered for 150 ;min and arterial blood glucose

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Etchie, Laju, Devaka Fernando, Vakkat Muraleedharan, and Ashok Poduval. "A Rare Cause of Severe Hypoglycaemia." Physician 6, no. 3 (2021): 1–5. http://dx.doi.org/10.38192/1.6.3.12.

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A 67-year old woman presented with an unwitnessed fall and decreased oral intake. She had a learning disability, hypertension, epilepsy, asthma, chronic iron deficiency anaemia, mild lymphopenia, osteoporosis and treated uterine cancer. After clinical review, she was treated for Hospital-acquired pneumonia (following a recent hospital admission) with possible aspiration. She was noted to have hyponatraemia secondary to dehydration. She was commenced on intravenous Levofloxacin and Metronidazole along with supportive care, based on antibiotic guidance due to her known allergy to penicillin.On d

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8

Setiani, Nur A., Rika L. Anggriani, and Anggi Restiasari. "Effect of Fermentation Time of Kombucha Tea on Its Hypoglycaemic Activity in Rats." Pharmacology and Clinical Pharmacy Research 4, no. 1 (2019): 5. http://dx.doi.org/10.15416/pcpr.v4i1.21384.

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Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycaemia. Functional food, such as kombucha tea, is widely used as complementary treatment for type 2 diabetes mellitus. Kombucha tea is made through fermentation process of green or black tea using a microbial kombucha consortium (Acetobacter xylinum and several types of yeast). The aim of this study was to evaluate the effect of fermentation time of kombucha tea on its hypoglycaemic activity in rats. The green tea (Camellia sinensis) was fermented with kombucha consortium for 8, 14, and 21 days. Evaluation of hypoglycae

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Proskurina, I. A., E. A. Petraneva, and D. V. Goryachev. "Recommendations on the Clinical Trial Programme for Diabetes Medicines." Bulletin of the Scientific Centre for Expert Evaluation of Medicinal Products 11, no. 2 (2021): 94–103. http://dx.doi.org/10.30895/1991-2919-2021-11-2-94-103.

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Diabetes is a serious public health problem and one of the major chronic noncommunicable diseases. A lengthy stepwise treatment, and the need for an individualised approach to antidiabetic therapy, pose serious challenges for medicine developers. For all new hypoglycaemic medicines, there has been a centralised authorisation procedure in the European Union (EU) since 2005, which ensures a unified approach to efficacy and safety assessment. The aim of the study was to analyse current requirements for planning clinical trials of hypoglycaemic medicines containing new active substances (except fo

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Zaccardi, Francesco, Suping Ling, Claire Lawson, Melanie J. Davies, and Kamlesh Khunti. "Severe hypoglycaemia and absolute risk of cause-specific mortality in individuals with type 2 diabetes: a UK primary care observational study." Diabetologia 63, no. 10 (2020): 2129–39. http://dx.doi.org/10.1007/s00125-020-05223-3.

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Abstract Aims/hypothesis Several pathophysiological mechanisms would suggest a causal link between hypoglycaemia and cardiovascular death; conversely, current knowledge would not support a causal relationship with other causes of death. To clarify the nature and the magnitude of the association between hypoglycaemia and death, we investigated the 5 year mortality risks for cardiovascular disease, cancer and other causes in individuals with type 2 diabetes admitted to hospital for a severe hypoglycaemic episode. Methods We defined in the UK Clinical Practice Research Datalink database a prevale

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Abdurrasyid, Z., M. Astawan, H. N. Lioe, and T. Wresdiyati. "Evaluation of hypoglycaemic potency in tempe with soybean germination process and extended fermentation time." Food Research 7, Supplementary 1 (2023): 217–27. http://dx.doi.org/10.26656/fr.2017.7(s1).32.

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One of the potential hypoglycaemic food from Indonesia is tempe. The use of germinated soybean and the extended fermentation time are potential methods to increase hypoglycaemic activity. In this study, the potential hypoglycaemic activity of tempe due to the use of germinated soybeans as raw material and the extended fermentation time (observation of 48, 72, and 96 hrs) was evaluated. The observations included insulinotropic free amino acids, soluble protein, peptides profile, antioxidants capacity, isoflavones, total phenolic compounds, and the α- glucosidase inhibitor activity. During the e

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Chepulis, Lynne, Hayder Al-Aubaidy, and Rachel Page. "The Hypoglycaemic Potential of Antioxidant-Rich Food Extracts." Functional Foods in Health and Disease 6, no. 8 (2016): 493. http://dx.doi.org/10.31989/ffhd.v6i8.271.

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Background: Obesity and diabetes are highly prevalent in Western countries, and both conditions can be associated with impaired glucose control and hyperglycemia. Antioxidants have been identified as having the ability to regulate blood glucose levels, however, the effects of specific high-antioxidant food extracts on blood glucose levels have not been well characterized. This study aimed to measure the hypoglycemic effects of selected antioxidant food extracts in healthy individuals.Methods: Ten healthy individuals were recruited into a randomized, single-blinded study. Participants consumed

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13

Sharma, S. R., S. K. Dwivedi, and D. Swarup. "Hypoglycaemic Potential of Mangifera indica Leaves in Rats." International Journal of Pharmacognosy 35, no. 2 (1997): 130–33. http://dx.doi.org/10.1076/phbi.35.2.130.13276.

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Yoshari, R. M., M. Astawan, E. Prangdimurti, and T. Wresdiyati. "The production process of tempe protein isolate from germinated soybeans and its potential as an antidiabetic." Food Research 7, Supplementary 1 (2023): 71–79. http://dx.doi.org/10.26656/fr.2017.7(s1).23.

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Physical activity limitations during the COVID-19 pandemic have the potential to be a community-wide risk factor for type 2 diabetic mellitus (DM). Tempe, an indigenous Indonesian food, can be developed into protein isolate for DM treatment. The protein isolates that were used in this study were tempe protein isolate from germinated soybeans (GTPI), tempe protein isolate from non-germinated soybeans (NGTPI), and commercial soybean protein isolate (CSPI) as a control. This study aimed to evaluate the effect of the soybean germination process on the production of tempe protein isolate (TPI) and

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Hepprich, Matthias, Kwadwo Antwi, Beatrice Waser, Jean Claude Reubi, Damian Wild, and Emanuel R. Christ. "Brunner’s Gland Hyperplasia in a Patient after Roux-Y Gastric Bypass: An Important Pitfall in GLP-1 Receptor Imaging." Case Reports in Endocrinology 2020 (April 4, 2020): 1–4. http://dx.doi.org/10.1155/2020/4510910.

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Severe cases of postprandial hypoglycaemia after bariatric surgery can be a diagnostic and therapeutic challenge. The diagnostic role of 68Ga-DOTA-Exendin-4 PET/CT in postbariatric hypoglycaemia for further treatment decisions is unclear. We present a case of a 50-year-old woman with frequent and severe postprandial hypoglycaemic (≤2.5 mmol/L) episodes starting three years after Roux-Y gastric bypass. Despite strict dietary adherence and several medical therapies, the patient remained severely affected, and 68Ga-DOTA-Exendin-4 PET/CT was performed to exclude atypical presentation of an insulin

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Malematja, R. O., V. P. Bagla, I. Njanje, et al. "Potential Hypoglycaemic and Antiobesity Effects ofSenna italicaLeaf Acetone Extract." Evidence-Based Complementary and Alternative Medicine 2018 (2018): 1–10. http://dx.doi.org/10.1155/2018/5101656.

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Background. Type II diabetes is on the rise while obesity is one of the strongest risk factors of type II diabetes. The search for a drug for type II that can equally mitigate obesity related complication is desired.Methods. The acetone leaf extract ofSenna italicawas evaluated for its cytotoxic, antiglycation, and lipolytic effect, glucose uptake, and GLUT4 translocation and expression using published methods, while that for adipogenesis and protein expression levels of obesity related adipokines was assessed using adipogenesis assay and mouse adipokine proteome profiler kit, respectively. Th

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Wang, Fang, Huan-Huan Zhong, Wei-Ke Chen, et al. "Potential hypoglycaemic activity phenolic glycosides from Moringa oleifera seeds." Natural Product Research 31, no. 16 (2016): 1869–74. http://dx.doi.org/10.1080/14786419.2016.1263846.

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18

Hwang, Janice J., and Robert S. Sherwin. "Verapamil is a potential therapy for hypoglycaemic brain injury." Nature Reviews Endocrinology 14, no. 8 (2018): 443–44. http://dx.doi.org/10.1038/s41574-018-0056-7.

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Priya, Satyam, Bhupendra PD Singh, and Arun Kumar. "Study of hypoglycaemics properties of aloe vera in alloxan-treated diabetic mice." PROCEEDINGS OF THE ZOOLOGICAL SOCIETY OF INDIA 23, no. 01 (2024): 117. http://dx.doi.org/10.59467/pzsi.2024.23.117.

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Diabetes mellitus is a chronic disease that has always been the primary health concern worldwide. A few herbal plants showed anti-diabetic potential, Aloe is among these few species, and the pharmacological effects may vary for Aloe leaf preparations. In the present study, we carried out a systematic and meta-analysis study to evaluate the hypoglycaemic properties of Aloe vera in Diabetes Mellitus Condition to develop its therapeutic benefit information and knowledge.. KEYWORDS :Aloe vera, Diabetes, Glucose, Hypoglycaemic, Mice

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L. M., Abhijith, and Ravi K. Sori. "Evaluation of antidiabetic activity of Tinospora cardifolia in alloxan induced diabetes in albino wistar rats." International Journal of Basic & Clinical Pharmacology 7, no. 7 (2018): 1382. http://dx.doi.org/10.18203/2319-2003.ijbcp20182686.

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Background: The objective was to evaluate the antidiabetic activity of Tinospora cardifolia in alloxan induced diabetes in albino rats in comparison with a currently used oral hypoglycaemic glibenclamide.Methods: there were 24 rats with FBS in the range 80-115 mg/dl were selected for the study. Four groups each containing six rats, were induced diabetes with alloxan (150mg/kg). The diabetic control group (0.5ml normal saline), Standard control group (5mg/kg glibenclimide), Test group I (200mg/kg T. cardifolia) and test II group 400mg/kg T. cardifolia). FBS was recorded on 1, 3, 7, 14, 21 and 2

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Horwitz, Jennifer, Linda Mardiros, Ahmed Musa, et al. "Scoping review of evidence for managing postnatal hypoglycaemia." BMJ Open 12, no. 2 (2022): e053047. http://dx.doi.org/10.1136/bmjopen-2021-053047.

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ObjectivesTo identify what is known empirically about the screening, treatment and harm of exposure to neonatal hypoglycaemia.DesignScoping review that applied a preregistered protocol based on established frameworks.Data sourcesMedline and Embase, up to 12 May 2020.Study selectionComparative and case-series studies, as well as guidelines, published in English or French, on the topic of immediate inpatient postnatal glucose screening in newborns.Data gatheringArticle selection and characterisation were performed in duplicate using predefined data extraction forms specific to primary studies an

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Loizzo, Monica, Paolo Lucci, Oscar Núñez, et al. "Native Colombian Fruits and Their by-Products: Phenolic Profile, Antioxidant Activity and Hypoglycaemic Potential." Foods 8, no. 3 (2019): 89. http://dx.doi.org/10.3390/foods8030089.

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The phenols and fatty acids profile and in vitro antioxidant and hypoglycaemic activity of seed, peel, pulp or pulp plus seeds of Colombian fruits from Solanaceae and Passifloraceae families were investigated. Ultra-High Performance Liquid Chromatography (UHPLC)-High Resolution Mass Spectrometry (HRMS) revealed the presence of chlorogenic acid as dominant phenolic compound in Solanaceae samples. Based on the Relative Antioxidant Score (RACI) and Global Antioxidant Score (GAS) values, Solanum quitoense peel showed the highest antioxidant potential among Solanaceae samples while Passiflora tripa

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Tenore, Gian Carlo, Paola Stiuso, Pietro Campiglia, and Ettore Novellino. "In vitro hypoglycaemic and hypolipidemic potential of white tea polyphenols." Food Chemistry 141, no. 3 (2013): 2379–84. http://dx.doi.org/10.1016/j.foodchem.2013.04.128.

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Bloomer, Karl. "A retrospective cross-sectional analysis of re-contact rates and clinical characteristics in diabetic patients referred by paramedics to a community diabetes service following a hypoglycaemic episode." British Paramedic Journal 6, no. 2 (2021): 1–9. http://dx.doi.org/10.29045/14784726.2021.9.6.2.1.

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Aims: To report the re-contact rates and clinical characteristics of individuals referred to community diabetic teams following non-conveyance by HCPC paramedics.Methods: A retrospective cross-sectional study of routinely collected data by the Northern Ireland Ambulance Service HSC Trust of individuals referred to a community diabetic service following ambulance attendance and non-conveyance. Data were collected over a 3-month period with ambulance service re-contact and clinical data analysed.Results: 418 emergency calls were identified as relating to hypoglycaemia with 169 referrals being ma

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Martin, G., and J. Rand. "Current Understanding of Feline Diabetes: Part 2, Treatment." Journal of Feline Medicine and Surgery 2, no. 1 (2000): 3–17. http://dx.doi.org/10.1053/jfms.2000.0057.

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When treating diabetic cats, the primary aim is to control clinical signs without causing clinical hypoglycaemia. Secondary goals are to maximise the chances of attaining diabetic remission and to minimise the risk of complications due to chronic hyperglycaemia. A treatment plan that is convenient for the owner is important for compliance. Underweight or overweight diabetic cats should be fed with the aim of normalising bodyweight. Current evidence suggests that non-obese diabetic cats can be fed ad libitum. The oral hypoglycaemic drug glipizide is well established as a treatment for about a t

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Teoh, Ik Hur, and Moulinath Banerjee. "Effect of ranolazine on glycaemia in adults with and without diabetes: a meta-analysis of randomised controlled trials." Open Heart 5, no. 2 (2018): e000706. http://dx.doi.org/10.1136/openhrt-2017-000706.

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BackgroundRanolazine is an antianginal drug reported to have hypoglycaemic effects.ObjectivesTo assess the effect of ranolazine versus placebo on glycaemic control for adults with and without diabetes.MethodsA systematic search of seven databases was conducted to identify all randomised controlled trials that compared the effect of ranolazine versus placebo on haemoglobin A1c (HbA1c) and/or fasting plasma glucose (FPG) and/or incidence of hypoglycaemia. We used mean differences in HbA1c and FPG to express intervention effect estimates and analysed the data with random-effects model for meta-an

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Thurlby, P. L., S. Wilson, and J. R. S. Arch. "Ciglitazone is not itself thermogenic but increases the potential for thermogenesis in lean mice." Bioscience Reports 7, no. 7 (1987): 573–77. http://dx.doi.org/10.1007/bf01119774.

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Chronic dietary administration of the oral hypoglycaemic ciglitazone (3 g/day for 14–28 days) to lean, non-diabetic CD1 mice resulted in increased brown adipose tissue mitochondrial GDP binding and a marked increase in the thermic effect of the beta-adrenoceptor agonist BRL 26830A. However, ciglitazone was not itself thermogenic after an acute dose, nor did it raise resting metabolic rate during chronic dietary dosing.

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Lattibeaudiere, Kemmoy, Roy Porter, and Ruby Lisa Alexander-Lindo. "The Isolation of Hypoglycaemic Compounds from Desmodium canum and Their Synergistic Effect on Blood Glucose Levels in Euglycaemic Sprague Dawley Rats." Evidence-Based Complementary and Alternative Medicine 2020 (October 19, 2020): 1–9. http://dx.doi.org/10.1155/2020/9465139.

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Desmodium canum (Strong back) commonly consumed as a tea or tonic is believed to possess hypoglycaemic activity. This paper sets out to isolate potential hypoglycaemic compounds present within the plant and investigate their synergistic effects on blood glucose levels in euglycaemic Sprague Dawley rats. The milled plant was sequentially extracted using hexane, ethyl acetate and methanol. The ethyl acetate extract was subjected to column chromatography yielding seven major fractions and were subsequently bioassayed using the Oral Glucose Tolerance Test (OGTT). Further chromatographic separation

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Musenge, Emmanuel Mwila, Lavina Prashar, Christian Chinyere Ezeala, and Fastone Mathews Goma. "Phytochemical Screening, median lethal dose and effects of Cassia abbreviata Oliv. crude extracts and fractions on oral glucose tolerance in non-diabetic male Wistar rats." Medical Journal of Zambia 50, no. 3 (2024): 202–16. http://dx.doi.org/10.55320/mjz.50.3.427.

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Background: Cassia abbreviata plant extracts are used traditionally to treat various ailments including diabetes mellitus. However, very few animal studies have been conducted to investigate potential hypoglycaemic effects locally. We examined phytochemicals, median lethal dose and effects of Cassia abbreviata extracts and fractions on oral glucose tolerance in non-diabetic male Wistar rats. Methods: Qualitative and Lorke’s methods were used to screen for phytochemicals and acute toxicity testing. Rats weighing 160 - 250 g were divided into 4 groups of 3 rats (phase one) and 4 groups of

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Loizzo, Monica R., Rosa Tundis, Federica Menichini, et al. "Chelating, antioxidant and hypoglycaemic potential ofMuscari comosum(L.) Mill. bulb extracts." International Journal of Food Sciences and Nutrition 61, no. 8 (2010): 780–91. http://dx.doi.org/10.3109/09637486.2010.482521.

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Kazeem, Mutiu Idowu, and Theophilus Clavell Davies. "Hypoglycaemic potential of leaf extracts ofLonchocarpus cyanescens(Schum. and Thonn) Benth." Transactions of the Royal Society of South Africa 71, no. 1 (2015): 1–6. http://dx.doi.org/10.1080/0035919x.2015.1078264.

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Lampiao, Fanuel, Samson Kafukiza, Denise Msowoya, Thokozire Phiri, Lina Wyson, and Louisa Alfazema. "EVALUATION OF THE HYPOGLYCAEMIC POTENTIAL OF KIGELIA AFRICANA FRUIT POWDER BEING SOLD IN MALAWIAN RETAIL PHARMACIES." African Journal of Traditional, Complementary and Alternative Medicines 15, no. 3 (2018): 27. http://dx.doi.org/10.21010/ajtcamv15i3.3.

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Background: Kigelia africana fruit powder is being sold in Malawian retail pharmacies for the purported purpose of lowering blood sugar in diabetic patients when there is scant data on its hypoglycaemic activity. This study was aimed at evaluating the hypoglycaemic potential of the Kigelia africana fruit powder being sold in Malawian retail pharmacies. Materials and Methods: Hyperglycaemia was induced in rats via intra-peritoneal injection of dexamethasone. Albino rats were randomly allocated into five different groups of eight rats each. Group 1 consisted of non-hyperglycaemic rats rece

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Kerr, David, Michael P. Diamond, William V. Tamborlane, Sara Kerr, and Robert S. Sherwin. "Influence of Counter-Regulatory Hormones, Independently of Hypoglycaemia, on Cognitive Function, Warning Symptoms and Glucose Kinetics." Clinical Science 85, no. 2 (1993): 197–202. http://dx.doi.org/10.1042/cs0850197.

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1. To assess the influence of counterregulatory hormones, independently of neuroglycopaenia, on higher cerebral (cognitive) function, ‘hypoglycaemic’ warning symptoms and glucose kinetics, 10 healthy subjects participated in two hyperinsulinaemic (2 m-units min−1 kg−1) glucose clamp studies. After 100 min of euglycaemia (plasma glucose level 5 mmol/l), the plasma glucose level was either (a) maintained at 5 mmol/l for 120 min by glucose infusion with concomitant replacement of counterregulatory hormones (continuous infusions of glucagon, adrenaline, noradrenaline, cortisol and growth hormone)

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Sanghi, Shail Bala, and Sabira Mushtaq. "AEGLE MARMELOS A POTENTIAL MEDICINAL TREE: AN OVERVIEW." International Journal of Research -GRANTHAALAYAH 5, no. 8 (2017): 63–66. http://dx.doi.org/10.29121/granthaalayah.v5.i8.2017.2183.

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Aegle marmelos family rutaceae is an alleged ayurvedic medicinal tree commonly known as the bael. It is medium sized tree growing throughout the forest of India of altitude 1200 meter. It is found all over India, from sub-Himalayan forest, Bengal, central and south India. It is considered to be a holy tree in India. Various parts of this plant such as leaves, roots, seed, bark and fruit, possess anti-microfilarial, antifungal, immunomodulatory, anti-proliferative, wound healing, antifungal, analgesic, anti-inflammatory, antipyretic, hypoglycaemic, antidyslipidemic, anti-fertility, and insectic

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Shail, Bala Sanghi, and Mushtaq Sabira. "AEGLE MARMELOS A POTENTIAL MEDICINAL TREE: AN OVERVIEW." International Journal of Research - Granthaalayah 5, no. 8 (2017): 63–66. https://doi.org/10.5281/zenodo.853297.

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Aegle marmelos family rutaceae is an alleged ayurvedic medicinal tree commonly known as the bael. It is medium sized tree growing throughout the forest of India of altitude 1200 meter. It is found all over India, from sub-Himalayan forest, Bengal, central and south India. It is considered to be a holy tree in India. Various parts of this plant such as leaves, roots, seed, bark and fruit, possess anti-microfilarial, antifungal, immunomodulatory, anti-proliferative, wound healing, antifungal, analgesic, anti-inflammatory, antipyretic, hypoglycaemic, antidyslipidemic, anti-fertility, and insectic

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Russo, Giuseppina T., Annalisa Giandalia, Elisabetta L. Romeo, et al. "Fracture Risk in Type 2 Diabetes: Current Perspectives and Gender Differences." International Journal of Endocrinology 2016 (2016): 1–11. http://dx.doi.org/10.1155/2016/1615735.

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Type 2 diabetes mellitus (T2DM) is associated with an increased risk of osteoporotic fractures, resulting in disabilities and increased mortality. The pathophysiological mechanisms linking diabetes to osteoporosis have not been fully explained, but alterations in bone structure and quality are well described in diabetic subjects, likely due to a combination of different factors. Insulin deficiency and dysfunction, obesity and hyperinsulinemia, altered level of oestrogen, leptin, and adiponectin as well as diabetes-related complications, especially peripheral neuropathy, orthostatic hypotension

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Olaitan, H. M. "Preliminary Evaluation of Methanol Extract of Aframomum melegueta seed for Hypoglycaemic Effect in Rats." Journal of Veterinary and Biomedical Sciences 1, no. 1 (2018): 11–18. http://dx.doi.org/10.36108/jvbs/8102.10.0120.

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Diabetes is a metabolic disease that has caused severe health complications and premature deaths in both developed and developing countries. It is characterized by hyperglycaemia. This study was designed to investigate the hypoglycaemic effect of methanol extract of Aframomum melegueta seed in Alloxan-induced diabetic rats. Adult albino rats of either sex weighing between 90 – 150 g were used. Diabetes was induced by administration of alloxan (100 mg/kg i.p). The rats were seperated into 5 groups of five rats each. Group I served as the negative control and was given normal saline (10 ml/kg p.

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Beseni, Brian K., Thabe M. Matsebatlela, Victor P. Bagla, et al. "Potential Antiglycation and Hypoglycaemic Effects ofToona ciliataM. Roem. andSchkuhria pinnataLam. Thell. Crude Extracts in Differentiated C2C12 Cells." Evidence-Based Complementary and Alternative Medicine 2019 (January 21, 2019): 1–12. http://dx.doi.org/10.1155/2019/5406862.

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Medicinal plants have been identified as a feasible avenue for the development of new potent antidiabetic agents. The phytoconstituent compositions of differentToona ciliataandSchkuhria pinnataextracts were determined and quantified using standard chemical methods after exhaustive extraction. Thereafter, their antioxidant and antiglycation potentials were spectrophotometrically determined. The cytotoxicity profiles of the extracts on C2C12 cells were determined using the MTT assay.Toona ciliatamethanol extract resulted in the highest percentage yield (20.83%) and high total phenols and flavono

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Tarfa, F. D., J. O. Igoli, A. I. Gray, G. I. Adoga, and K. S. Gamaniel. "Characterization of potential hypoglycaemic agents from Tapinanthus sessilifolius parasitic on Psidium guajava." Journal of Phytomedicine and Therapeutics 21, no. 2 (2022): 1003–16. http://dx.doi.org/10.4314/jopat.v21i2.19.

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Tapinanthus sessilifolius (Loranthaceae) (P. Beauv) Blume. commonly known as African mistletoe is a well-known medicinal plant in Africa and Europe. A bioassay-guided isolation of the plant constituents was carried out to identify potential anti-hyperglycemic agents. The hexane extract was discovered to be active which yielded two triterpenoids; betulinic acid and lupeol, responsible for the activity and their structures were elucidated by spectroscopic techniques. Other compounds from this plant identified by GC-MS technique were palmitic acid, hexadecanoic acid and stearic acid.

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Ullah, Riaz, Abdelaaty A. Shahat, Ahmed A. Hammad, et al. "Moricandia sinaica (Boiss.): A Potent Source of Hypoglycaemic and Antidiabetic Remedy." Journal of Food Quality 2023 (December 15, 2023): 1–7. http://dx.doi.org/10.1155/2023/6658241.

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Here, we evaluated the antidiabetic and hypoglycaemic activities of Moricandia sinaica, a species of the Brassicaceae family, for the first time. The hypoglycaemic and antidiabetic activities of the M. sinaica shoot’s methanol extract (MOR-1), butanol fraction (MOR-2), and aqueous fraction (MOR-3) were examined against streptozotocin-induced diabetes model in albino Swiss mice. The mice were divided into eight groups (each group consisted of 6 mice). MOR-1 (100 and 200 mg/kg), MOR-2 (100 and 200 mg/kg), and MOR-3 (100 and 200 mg/kg) were administered to groups III, IV, V, VI, VII, and VIII, re

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Ajeet, Singh, and Navneet. "Ethnobotanical, Pharmacological, Antimicrobial Potential and Phytochemistry of Parthenium hysterophorus Linn. : An Update." International Journal of Toxicological and Pharmacological Research 9, no. 4 (2017): 229–35. https://doi.org/10.5281/zenodo.12697568.

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<em>Parthenium hysterophorus </em>(Linn.) is violent everywhere annual, herbivorous weed. It is commonly known as congress grass or gajar ghas. <em>P. hysterophorus</em> shown several hazardous effects on human health and livestock. It reduces the crop production due to its allelopathic effect. In spite of these drawbacks <em>P. hysterophorus</em> is traditionally recognized for its use in the treatment of wounds, fever, ulcerated sores and malaria. It is a weed of global importance. Pharmacological investigation revealed that it possess several therapeutic application

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Thinn, Ngu Wah, Zaw Khaing OO, and Saw Sandar Maw. "INVESTIGATION OF HYPOGLYCAEMIC ACTIVITY OF SOME MYANMAR MEDICINAL PLANTS." International Journal of Technical Research & Science 3, no. 03 (2018): 104–8. http://dx.doi.org/10.30780/ijtrs.v3.i3.2018.011.

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The hypoglycaemic activities of three ethanolic extracts prepared from leave of Orthosiphon aristatus (Blume) Miq., Andrographis paniculata (Nees) and bark of Azadirachta indica (A.Juss) were investigated in this study. According to preliminary phytochemical examination, the three plants showed the absence of cyanogenic glycosides and the presence of antibiotic potential of constituents. In vitro and vivo toxicity test, these selected plants were potentially safe for medicinal use. Among these three extracts, O. aristatus showed the most significant reduction in fasting blood glucose (FBG) lev

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Ekanem, Norah Godwin, Herbert Orji Chidi Mbagwu, and Gamaliel Ibiama Harry. "Phytochemical screening and hypoglycaemic activity of Lasianthera africana Beauv. (Aquifoliales: Stemonuraceae) leaf extract on diabetic rats." Brazilian Journal of Biological Sciences 3, no. 6 (2016): 293–98. http://dx.doi.org/10.21472/bjbs.030606.

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Lasianthera africana Beauv. (Aquifoliales: Stemonuraceae) is a native leafy vegetable used in traditional medicine for control and management of problems associated with complications of diabetes mellitus. The study was aimed to evaluate the phytochemical and hypoglycaemic properties for effective control of diabetes. Phytochemical analyses were conducted using standard methods. The rats were divided into four groups of six rats each of which Group 1 received distilled water (1 mL); Group 2 received aqueous extract (doses of 500 mg/kg, 1,000 mg/kg and 1,500 mg/kg); Group 3 received ethanolic e

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Ndile, Michael Musila, Wilton Mwema Mbinda, and Mathew Piero Ngugi. "Caesalpinia volkensii: Unexploited Natural Source of Medicine." Journal of Phytopharmacology 7, no. 3 (2018): 288–91. http://dx.doi.org/10.31254/phyto.2018.7310.

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The plant of the species Caesalpinia volkensii has diverse traditional use. This review aims at providing an overview of the plants traditional utility and scientific potential in managing both infectious and lifestyle diseases. It focuses on the plants hypoglycaemic activity, anti-malarial, anti-nociceptive and anti-inflamatory activity. The review also looks at the antimicrobial property of the plant, phytochemical analysis and safety

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Platel, Kalpana, and K. Srinivasan. "Plant foods in the management of Diabetes mellitus: Vegetables as potential hypoglycaemic agents." Food / Nahrung 41, no. 2 (1997): 68–74. http://dx.doi.org/10.1002/food.19970410203.

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BanglaJOL, Administrator. "Hypoglycaemic Status in Low Birth Weight Neonates During First 48 Hours of Life." Journal of Armed Forces Medical College, Bangladesh 9, no. 1 (2014): 49–56. http://dx.doi.org/10.3329/jafmc.v9i1.18726.

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Introduction: In developing countries more than 90% infants are born with low birth weight (LBW). In Bangladesh the incidence is about 30%. Newborn baby has got a definite difference in metabolic profile from the adult; this difference is much more pronounced in case of LBW newborn. Infants born prematurely or following intrauterine malnutrition may develop abnormally low plasma glucose concentration for a prolonged period as a result of the failure to adapt a metabolic and endocrine response.Glucose is an essential nutrient for the brain. Abnormally low levels (hypoglycaemia) can cause enceph

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Laird, Elizabeth Ann, Vivien E. Coates, Assumpta A. Ryan, Mark O. McCarron, Diane Lyttle, and David Chaney. "An Investigation of the Glucose Monitoring Practices of Nurses in Stroke Care: A Descriptive Cohort Study." Nursing Research and Practice 2013 (2013): 1–7. http://dx.doi.org/10.1155/2013/715802.

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Glucose derangement is commonly observed among adults admitted to hospital with acute stroke. This paper presents the findings from a descriptive cohort study that investigated the glucose monitoring practices of nurses caring for adults admitted to hospital with stroke or transient ischaemic attack. We found that a history of diabetes mellitus was strongly associated with initiation of glucose monitoring and higher frequency of that monitoring. Glucose monitoring was continued for a significantly longer duration of days for adults with a history of diabetes mellitus, when compared to the rema

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Winocour, Peter H., Karen Moore-Haines, Keith Sullivan, Anne Currie, Andrew Solomon, and Dawn Hardy. "HbA1c in a primary care cohort with diabetes and chronic kidney disease: the East and North Hertfordshire Institute of Diabetes and Endocrinology (ENHIDE) Diabetes Renal Telehealth Project." British Journal of Diabetes 20, no. 2 (2020): 130–37. http://dx.doi.org/10.15277/bjd.2020.252.

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Aim: Diabetes mellitus and chronic kidney disease (CKD) commonly co-occur. Control of glycaemia is nuanced, and should be individualised. The Diabetes Renal Telehealth Project identified 2,356 adults with diabetes and CKD, and evaluated determinants and patterns of HbA1c in order to identify under-treatment or potential over-treatment of glycaemia.Method: Comprehensive review of GP diabetes registers by the clinical investigators.Results: The study subjects (52% male, 48% female) were aged 77 years (range 19–103) with median estimated glomerular filtration rate 52 (range 3–171) mL/min and medi

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ANORUE, E. C., E. C. MBEGBU, G. I. NGWU, K. N. IBEMENUGA, and J. E. EYO. "Hypoglycaemic and Hypolipidemic Effects of Black Brand of Lipton Tea (Camellia sinensis) on Normal Male Albino Rats." Notulae Scientia Biologicae 11, no. 1 (2019): 94–101. http://dx.doi.org/10.15835/nsb11110370.

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Recently, considerable attention has been focused on dietary supplements that possess hypoglycaemic and hypolipidemic properties in lieu of the synergistically synthesized drugs like statins and metiform which have been proven to have adverse effects. This present work was carried out to study the potential effects of Lipton tea aqueous extract (LTAE) on normal male albino rats. 36 six male Wistar rats weighing 115-150 g were assigned into four main groups; each group was divided into three subgroups, consisting of three replicates namely R1, R2 and R3 making a total of nine rats in each of th

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Lindelwa, Zimu, and Mahomed Ozayr. "Prevalence and determinants of poor glycaemic control in individuals aged between 18-60 years, at a regional hospital in KwaZulu-Natal Province, South Africa- a cross sectional study." African Health Sciences 23, no. 4 (2023): 339–47. http://dx.doi.org/10.4314/ahs.v23i4.36.

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Background: Achieving optimal blood glucose control is imperative for preventing diabetes related complications and negative socio-economic consequences associated with them.Objectives: The aim of the study was to determine the prevalence and determinants of poor glycaemic control amongst type II diabetic outpatients presenting at a regional semi-rural hospital in eThekwini district, Kwa-Zulu Natal.Methods: An observational, analytic cross-sectional study was conducted amongst 384 systematically sampled type 2 diabetes patients. Data were collected by an interviewer administered questionnaire,

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