Relevant bibliographies by topics / Hypoglycemic and hypolipidemic effects

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  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
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Academic literature on the topic 'Hypoglycemic and hypolipidemic effects'

Author: Grafiati
Published: 7 June 2025
Last updated: 26 June 2025

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Journal articles on the topic "Hypoglycemic and hypolipidemic effects"

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Abousamra, Mona M., Mona Basha, Sally El Awdan та Nasser S. M. Ismail. "EFFECT OF METHYL-Β-CYCLODEXTRIN COMPLEXATION ON THE HYPOGLYCEMIC AND HYPOLIPIDEMIC EFFECTS OF KHELLIN: EXPERIMENTAL STUDY". International Journal of Pharmacy and Pharmaceutical Sciences 8, № 11 (2016): 165. http://dx.doi.org/10.22159/ijpps.2016v8i11.14365.

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Objective: The present work tackled the development and evaluation of inclusion complex of khellin (KH) and methyl-β-cyclodextrin (MβCD). In addition, it tested its possible hypoglycemic and hypolipidemic effects.Methods: Inclusion complexes of KH-MβCD in the presence of water-soluble polymer were prepared by freeze drying (FD), co-evaporation (EV) and kneading methods (KN). The selected ternary complex was characterized by Fourier transform infrared spectrophotometry (FTIR), x-ray diffractometry (XRD), differential scanning calorimetry (DSC) and scanning electron microscopy [1]. Assessment of the hypoglycemic effect of the selected ternary complex versus the standard drug metformin was studied. Two different doses of the ternary complex were administered orally to streptozotocin (STZ)-induced type 2diabetic rats. Their hypoglycemic and hypolipidemic effects were evaluated by measuring the fasting blood glucose level (BGL), total cholesterol (TC) and triglycerides levels (TG) along the study period.Results: The FD complex showed the highest drug dissolution rate. All the performed characterization analysis confirmed the formation of a KH-MβCD inclusion complex. The in vivo study declared that both doses showed a marked hypoglycemic and hypolipidemic effects compared to metformin.Conclusion: In conclusion, this study points for the first time that the complexation of KH with MβCD could notably improve the dissolution rate and hence the bioavailability of KH. Moreover, this study demonstrated that this compound has a hypoglycemic and hypolipidemic effect. Thus, it can be a promising natural supportive treatment in type 2 diabetes mellitus (T2DM).
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Joseph, P. K., and R. T. Kasinath. "Hypoglycemic and hypolipidemic effects of diacetodibutyl disulphide." Indian Journal of Clinical Biochemistry 15, no. 2 (2000): 68–75. http://dx.doi.org/10.1007/bf02883731.

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Wang, Kaiping, Peng Cao, Weizhi Shui, Qiuxiang Yang, Zhuohong Tang, and Yu Zhang. "Angelica sinensis polysaccharide regulates glucose and lipid metabolism disorder in prediabetic and streptozotocin-induced diabetic mice through the elevation of glycogen levels and reduction of inflammatory factors." Food & Function 6, no. 3 (2015): 902–9. http://dx.doi.org/10.1039/c4fo00859f.

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Habib, M. Anwar, ASM Anisuzzaman, RK Barman, M. Abdul Gafur, and M. Tofazzal Haque. "Isolation and Characterization of Hypolipidemic Compound from Cajanus cajan." TAJ: Journal of Teachers Association 24, no. 1 (2011): 6–10. http://dx.doi.org/10.3329/taj.v24i1.37441.

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The study was carried out to identify the compound responsible for hypolipidemic and hypoglycemic effects of Cajanus cajan (redgram). The methanol extract of redgram seeds was found to decrease fasting blood glucose and lipid profile (p<0.001) on streptozotocin-induced mice compared to control. This activity- guided fraction led to the isolation of a compound, substituted benzene containing polyhydroxy functions fused with lactone (CCA3) by analysis of 1H and 13C-NMR data. Biological studies of the isolated compound possessed prominent hypolipidemic activity. Although a number of hypoglycemic compounds are reported, yet not any hypolipidemic compound from redgram. The compound CCA3 seems to be the first report on hypolipidemic activity from methanol extract of redgram.
 TAJ 2011; 24(1): 6-10
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Tu, Lanlan, Rui Wang, Zheng Fang, et al. "Assessment of the Hypoglycemic and Hypolipidemic Activity of Flavonoid-Rich Extract from Angelica keiskei." Molecules 27, no. 19 (2022): 6625. http://dx.doi.org/10.3390/molecules27196625.

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Angelica keiskei contains a variety of bioactive compounds including chalcone, coumarin, and phytochemicals, endowing it with pharmacological effects such as lipid-lowering activity, antitumor activity, liver protection, and nerve protection. This study aims to study the hypoglycemic and hypolipidemic effects of the flavonoid-rich extract from Angelica keiskei (FEAK) in an effort to exploit new applications of FEAK and increase its commercial value. In this paper, flavonoid compounds in Angelica keiskei were extracted using 50% ethanol, and the contents of the flavonoid compounds were analyzed by UPLC-MS/MS. Then, the hypoglycemic and hypolipidemic activities of the FEAK were investigated through in vitro enzyme activity and cell experiments as well as establishing in vivo zebrafish and Caenorhabditis elegans (C. elegans) models. The UPLC-MS/MS results show that the major flavonoid compounds in the FEAK were aureusidin, xanthoangelol, kaempferol, luteolin, and quercetin. The inhibitory rates of the FEAK on the activity of α-amylase and cholesterol esterase were 57.13% and 72.11%, respectively. In cell lipid-lowering experiments, the FEAK significantly reduced the total cholesterol (TC) and total triglyceride (TG) levels in a dose-dependent manner, with 150 μg/mL of FEAK decreasing the intracellular levels of TC and TG by 33.86% and 27.89%, respectively. The fluorescence intensity of the FEAK group was 68.12% higher than that of the control group, indicating that the FEAK exhibited hypoglycemic effects. When the concentration of the FEAK reached 500 μg/mL, the hypoglycemic effect on zebrafish reached up to 57.7%, and the average fluorescence intensity of C. elegans in the FEAK group was 17% lower than that of the control group. The results indicate that the FEAK had hypoglycemic and hypolipidemic activities. The findings of this study provide theoretical references for the high-value utilization of Angelica keiskei and the development of natural functional food with hypoglycemic and hypolipidemic activities.
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Zhou, Ji-Yin, Shi-Wen Zhou, Sheng-Ya Zeng, Jian-Yun Zhou, Ming-Jin Jiang, and Yan He. "Hypoglycemic and Hypolipidemic Effects of Ethanolic Extract ofMirabilis jalapaL. Root on Normal and Diabetic Mice." Evidence-Based Complementary and Alternative Medicine 2012 (2012): 1–9. http://dx.doi.org/10.1155/2012/257374.

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The present study investigated the insulin sensitivity, hypoglycemic, and hypolipidemic activities of ethanolic extract ofMirabilis jalapaL. root (EEM) in normal and diabetic mice. After induction of diabetes with streptozotocin, both normal and diabetic mice were singly or repeatedly for 28 days administrated with EEM at doses of 2, 4, 8 g/kg, respectively. Before induction of diabetes, mice were administrated with EEM at doses of 2, 4, 8 g/kg for 14 days and were injected with streptozotocin and continued on EEM administration for another 28 days. Both after and before induction of diabetes, repeated administration with 4, 8 g/kg EEM continually lowered blood glucose level, decreased serum insulin level and improved insulin sensitivity index, and lowered serum total cholesterol, triglyceride levels and triglyceride content in liver and skeletal muscle, and increased glycogen content in these tissues; but repeated administration had no influence on those indexes of normal mice. Single administration with EEM (4, 8 g/kg) showed hypoglycemic effect in oral glucose tolerance test in normal and diabetic mice. Single administration with EEM had no hypoglycemic and hypolipidemic effects on normal and diabetic mice. These results suggest that EEM possesses both potential insulin sensitivity, hypoglycemic, and hypolipidemic effects on diabetes.
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Xu, Jialin, Tingting Liu, Yuanyuan Li, et al. "Hypoglycemic and hypolipidemic effects of triterpenoid-enriched Jamun (Eugenia jambolana Lam.) fruit extract in streptozotocin-induced type 1 diabetic mice." Food & Function 9, no. 6 (2018): 3330–37. http://dx.doi.org/10.1039/c8fo00095f.

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Jia, Sheng, Ying Hu, Wenna Zhang, et al. "Hypoglycemic and hypolipidemic effects of neohesperidin derived from Citrus aurantium L. in diabetic KK-Aymice." Food & Function 6, no. 3 (2015): 878–86. http://dx.doi.org/10.1039/c4fo00993b.

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Chen, Zhongqin, Cong Wang, Yuxiang Pan, Xudong Gao, and Haixia Chen. "Hypoglycemic and hypolipidemic effects of anthocyanins extract from black soybean seed coat in high fat diet and streptozotocin-induced diabetic mice." Food & Function 9, no. 1 (2018): 426–39. http://dx.doi.org/10.1039/c7fo00983f.

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Yang, Chang, Qi Feng, Huan Liao, Xinlei Yu, Yang Liu та Di Wang. "Anti-Diabetic Nephropathy Activities of Polysaccharides Obtained from Termitornyces albuminosus via Regulation of NF-κB Signaling in db/db Mice". International Journal of Molecular Sciences 20, № 20 (2019): 5205. http://dx.doi.org/10.3390/ijms20205205.

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Termitornyces albuminosus is a kind of traditional Chinese edible fungus rich in nutrients and medicinal ingredients, and it has anti-oxidative, analgesic and anti-inflammatory effects. However, the hypoglycemic and nephroprotective effects of polysaccharides separated from T. albuminosus (PTA) have not been reported. The properties of PTA were analyzed in a BKS.Cg-Dock7m +/+ Leprdb/JNju (db/db) mouse model of diabetes. After the administration of PTA for eight weeks, the hypoglycemic and hypolipidemic activities of PTA in the db/db mice were assessed. The results of a cytokine array combined with an enzyme-linked immunosorbent assay confirmed the anti-oxidative and anti-inflammatory activities of PTA. An eight-week administration of PTA caused hypoglycemic and hypolipidemic functioning, as indicated by suppressed plasma glucose levels, as well as the modulation of several cytokines related to glycometabolism, in the sera and kidneys of the mice. PTA treatment also had a protective effect on renal function, restoring renal structures and regulating potential indicators of nephropathy. In the kidneys of the db/db mice, PTA treatment reduced the activation of protein kinase B, the inhibitor of κB kinase alpha and beta, and the inhibitor of κB alpha and nuclear factor-κB (NF-κB). We establish the hypoglycemic, hypolipidemic, and anti-diabetic nephropathy effects of PTA, and we find that the renal protection effects of PTA may be related to anti-inflammatory activity via the regulation of NF-κB signaling.
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Dissertations / Theses on the topic "Hypoglycemic and hypolipidemic effects"

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Frota, Julyanne Torres. "Evaluation of hypoglycemic and hypolipidemic activity of mixture of α,β-amyrin, pentacyclic triterpenes isolated of protium heptaphyllum in mice." Universidade Federal do CearÃ, 2011. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=6886.

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nÃo hÃ<br>The Protium heptaphyllum (almecegueira) exudes an amorphous resin consisting of four binary mixtures of triterpenoids, and the mixture of &#61537;,&#61538;-amyrin its major constituent. In folk medicine, the resin of Protium heptaphyllum is used as anti-inflammatory, gastroprotective, analgesic, expectorant and healing. The mixture of pentacyclic triterpenes &#61537;,&#61538;-amyrin (AB) (63:37) has gastroprotective, antipruritic, antiinflammatory and antioxidant properties. Experimental studies with pentacyclic triterpene compounds belonging to the groups ursan, oleanan and lupan showed inhibition of different enzyme systems intimately related to metabolism/absorption of carbohydrates and lipids. Thus the hypoglycemic and hypolipidemic activity of AB was evaluated in Swiss mice, the models of diabetes induced by streptozotocin (STZ) and alloxan (ALX) and hyperlipidemia induced by triton WR-1339 and hyperlipidemic diet (DH). AB (10, 30 and 100mg/kg) was able to reduce blood glucose in a model of acute treatment in STZ-induced diabetes, we observed two times (3 and 5 hours after administration of AB). In five days after treatment of diabetic animals by ALX, AB (30 and 100 mg/kg) also decreased hyperglycemia, an effect also observed for the use of glibenclamide (10 mg/Kg) in both models. But in normal animals, AB did not affect blood glucose, unlike the positive control glibenclamide (10 mg/kg). Although the model of diabetes for ALX, AB reduced total cholesterol (TC) serum at a dose of 100mg/kg, and triglycerides (TG) at doses of 30 and 100 mg/kg. In this same model, reduced the serum amylase AB (AB 30 and 100 mg/kg) and serum lipase (AB 100 mg/kg), a result also observed in normal animals, the same doses. In the Oral Glucose Tolerance Test (OGTT), AB (30 and 100 mg/kg) was shown to reduce blood glucose levels 60 min after administration of glucose, and AB (10, 30 and 100 mg/kg) in 90 min. In the model of hyperlipidemia by triton, AB (10, 30 and 100 mg/kg) significantly reduced the levels of TC and TG, in times of 24 and 48 h after administration of triton, an effect also observed for fenofibrate (200 mg/kg) used as positive control. The levels of HDL-c elevation experienced with the use of AB at all doses and times observed, as well as fenofibrate. In the model of hyperlipidemia by HD, AB (10, 30 and 100 mg/kg) controlled weight gain of animals receiving HD, as well as reduced TC, TG, LDL-c and VLDL-c, although the latter only in doses 30 and 100 mg/kg. These two doses were also effective in raising HDL-c. All doses of AB administered reduced the atherogenic index. All doses of AB also reduced the hepatic cholesterol in this model. All effects reported were similar to the positive control (fenofibrate 200 mg/kg). AB (10, 30 and 100 mg/kg) was able to significantly improve the antioxidant defenses of the liver, because it elevated the activity of hepatic SOD and CAT when compared to control high-fat diet, and raised the level of NP-SH in dose of 100 mg/kg, as well as reduced lipid peroxidation by decreasing the MDA, at all doses. Together, these results indicate that &#945;,&#946;-amyrin has hypolipidemic and hypoglycemic effect and deserves further evaluation in larger animal models that simulate chronic conditions of diabetes and dyslipidemia, in addition to research on their mechanism of action.<br>O Protium heptaphyllum (almecegueira) exsuda uma resina amorfa constituÃda de quatro misturas binÃrias de triterpenÃides, sendo a mistura de &#61537;,&#61538;-amirina o constituinte majoritÃrio. Na medicina popular, a resina de Protium heptaphyllum à utilizada como antiinflamatÃria, gastroprotetora, analgÃsica, expectorante e cicatrizante. A mistura de triterpenos pentacÃclicos &#61537;,&#61538;-amirina (AB) (63:37) possui propriedades gastroprotetora, antipruriginosa, antiinflamatÃria e antioxidante. Estudos experimentais com compostos triterpÃnicos pentacÃclicos que pertencem ao grupo ursano, oleanano e lupano mostraram a inibiÃÃo de diferentes sistemas enzimÃticos intimamente relacionados ao metabolismo/absorÃÃo de carboidratos e lipÃdios, deste modo, a atividade hipoglicemiante e hipolipemiante de AB foi avaliada, em camundongos Swiss, nos modelo de diabetes induzida por estreptozotocina (STZ) e por aloxano (ALX) e hiperlipidemia induzida por triton WR-1339 e dieta hiperlipidÃmica (DH). AB (10, 30 e 100mg/Kg) foi capaz de reduzir a glicemia num tratamento agudo no modelo de diabetes induzida por STZ, nos dois tempos observados (3 e 5h apÃs administraÃÃo de AB). Em tratamento apÃs cinco dias de animais diabÃticos por ALX, AB (30 e 100mg/Kg) tambÃm diminuiu a hiperglicemia, efeito este, tambÃm observado para o uso de glibenclamida (10mg/Kg) nos dois modelos. PorÃm em animais normais, AB nÃo alterou a glicose sanguÃnea, ao contrÃrio do controle positivo glibenclamida (10 mg/Kg). Ainda no modelo de diabetes por ALX, AB reduziu o colesterol total (CT) sÃrico na dose de 100mg/Kg, bem como os triglicerÃdeos (TG) nas doses de 30 e 100 mg/Kg. Neste mesmo modelo, AB reduziu a amilase sÃrica (AB 30 e 100 mg/Kg) e a lipase sÃrica (AB 100mg/Kg), resultado este observado tambÃm em animais normais, nas mesmas doses. No Teste Oral de TolerÃncia à Glicose (TOTG), AB (30 e 100 mg/Kg) mostrou reduzir a glicemia 60 min apÃs a administraÃÃo de glicose, bem como AB (10, 30 e 100 mg/Kg) em 90 min. No modelo de hiperlipidemia por triton WR-1339, AB (10, 30 e 100mg/Kg) reduziu de forma significativa os nÃveis de CT e TG, nos tempos de 24h e 48h apÃs a administraÃÃo do triton WR-1339, efeito observado tambÃm para fenofibrato (200mg/Kg) utilizado como controle positivo. Os nÃveis de HDL-c sofreram elevaÃÃo com o uso de AB em todas as doses e tempos observados, assim como o fenofibrato. No modelo de hiperlipidemia por DH, AB (10, 30 e 100mg/Kg) controlou o ganho de peso dos animais que receberam a DH, bem como reduziram CT, TG, LDL-c e VLDL-c, porÃm este Ãltimo somente nas doses de 30 e 100mg/Kg. Estas duas doses tambÃm foram eficazes para elevar o HDL-c. Todas as doses de AB administradas reduziram o Ãndice aterogÃnico. Todas as doses de AB tambÃm reduziram o colesterol hepÃtico neste modelo. Todos os efeitos relatados foram similares ao controle positivo (fenofibrato 200mg/Kg). AB (10, 30 e 100 mg/Kg) foi capaz de melhorar significativamente as defesas antioxidantes do tecido hepÃtico, pois elevou a atividade das enzimas catalase e superÃxido dismutase hepÃticas, quando comparado ao controle dieta hiperlipÃdica, bem como elevou o nÃvel dos grupos sulfidrÃlicos nÃo protÃicos na dose de 100mg/Kg, assim como reduziu a peroxidaÃÃo lipÃdica ao diminuir o malondialdeÃdo, em todas as doses. Em conjunto, esses resultados indicam que &#945;,&#946;-amirina possui efeito hipoglicemiante e hipolipemiante e que merece maior avaliaÃÃo futura em modelos animais que simulem situaÃÃes crÃnicas de diabetes e dislipidemias, alÃm de pesquisa de seu mecanismo de aÃÃo.
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Roffey, Ben. "The effects of Momordica charantia and cinnamon extracts on glucose uptake and adiponectin secretion in 3T3-L1 adipose cells /." Thesis, McGill University, 2006. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=98782.

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To examine the effects of Momordica charantia (MC) and cinnamon on glucose uptake and adiponectin secretion (AS) fat cells, 3T3-L1 adipocytes were treated with a water extract of cinnamon (CE) and three concentrations of MC water and ethanol extracts. The treatment combination of 0.2 mg/ml MC water extract and 0.5 nM insulin was associated with an increased glucose uptake into the cells (61%) and increased AS from the cells (75%). Without insulin, 0.2 mg/ml of CE increased glucose uptake (100%) and completely inhibited AS from the cells. Sub-optimal concentrations of insulin did not further enhance the CE activity and, in combination with 50 nM insulin, a dose-dependent decrease in glucose uptake was observed. The present results indicate that preferentially water-soluble component(s) in MC enhance the glucose uptake action of sub-optimal concentrations of insulin in 3T3-L1 adipocytes. This effect is accompanied by and may be a result of increased AS. CE increases glucose uptake in these adipocytes but inhibits AS.
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Lau, Vivian Wai Yan 1977. "Effects of plant sterols on plasma lipid profiles, glycemic control of hypercholesterolemic individuals with and without type 2 diabetes." Thesis, McGill University, 2003. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=80312.

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Plant sterols (PS) are effective in reducing plasma lipid concentrations, however, few studies have examined their cholesterol lowering effects in type 2 diabetics. The objective was to assess whether PS consumption alters blood lipid profile in hypercholesterolemic subjects with and without type 2 diabetes. Fifteen control subjects (age = 55.1 +/- 8.5 yr and BMI = 26.9 +/- 3.0kg/m2) and fourteen diabetic subjects (age = 54.5 +/- 6.7 yr and BMI = 30.2 +/- 3.0kg/m2) participated in a double-blinded, randomized, crossover, placebo-controlled feeding trial. The Western diet included either 1.8g/d of PS or cornstarch placebo each provided over 21 d separated by a 28 d washout period. Subjects consumed only foods prepared in Mary Emily Clinical Nutrition Research Unit of McGill University. Total cholesterol (TC) decreased (p < 0.05) from baseline with PS for control and diabetic subjects by 9.7% and 13.6%, respectively. TC decreased (P < 0.05) from baseline with placebo for control and diabetic subjects by 10.9% and 11.6%, respectively. Non high density lipoprotein cholesterol (non-HDL-C) decreased (p < 0.05) from baseline with PS for diabetic subjects by 18.5%. Low density lipoprotein cholesterol (LDL-C) levels were reduced (p < 0.05) from baseline with PS for control and diabetic subjects by 14.9% and 29.8%, respectively. The reduction of LDL-C due to PS alone is greater with type 2 diabetics. There were no significant changes in HDL-C and TG across diets or treatments. It is thus concluded that PS consumption with diet enhances non-HDL-C and LDL-C reduction compared with diet alone in hypercholesterolemic individuals with and without type 2 diabetes. Demonstration for the first time that PS alone are more efficacious in lowering LDL-C and non-HDL-C in diabetic individuals compared to non-diabetics confirm the beneficial effects of PS to help prevent cardiovascular disease (CVD) for this high risk population.
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Al-Salami, Hani, and n/a. "The combination of probiotics, 12-monoketocholic acid (bile acid) and gliclazide in a rat model of type 1 diabetes : hypoglycemic effects, pharmacokinetics and transport studies." University of Otago. School of Pharmacy, 2009. http://adt.otago.ac.nz./public/adt-NZDU20090903.150030.

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Type 1 diabetes (T1D) is a metabolic disorder characterized by destruction of the pancreatic beta-islet cells leading to complete loss of insulin production. Gliclazide is used in Type 2 diabetes (T2D) to stimulate insulin production but it also has beneficial extrapancreatic effects which make it potentially useful in T1D. In fact, some T2D patients continue to use gliclazide even after their diabetes progresses to T1D since it provides better glycemic control than insulin alone. About 30% of a gliclazide dose undergoes enterohepatic recirculation which may contribute to the observed high interindividual variability in its pharmacokinetics. This may limit its efficacy in T1D especially since diabetes can disturb the gut microbiota and give rise to changes in bile composition and enterohepatic recirculation. Improving the absorption of gliclazide through the use of bile acids and probiotics may reduce this variability and improve the efficacy of gliclazide in T1D. The aim of this thesis was to investigate the interaction between the semisynthetic bile acid, 12-monoketocholic acid (MKC) and gliclazide in terms of pharmacokinetics and hypoglycemic effects in a rat model of T1D with and without probiotic pretreatment. A parallel ex vivo (Ussing chamber) study was carried out to investigate the mechanism of the interaction. Sensitive LC-MS and HPLC methods (Chapter 2) were developed to determine the concentrations of gliclazide and MKC in Ringer's solution and rat serum. Diabetes was induced in male Wistar rats by intravenous (i.v.) alloxan (30 mg/kg). Rats with blood glucose concentration > 18 mmol/l and serum insulin concentration < 0.04 [mu]g/l, 2-3 days after alloxan injection were considered diabetic. A total of 280 male Wistar rats (Chapter 3) were randomly allocated into 28 groups (n=10) of which 14 were made diabetic. Then 7 groups of healthy and 7 groups of diabetic rats were gavaged with probiotics (10⁸ CFU/mg, 75 mg/kg) every 12 hours for three days after which single doses of gliclazide (20 mg/kg), MKC (4 mg/kg) or the combination were administered either by tail vein injection (i.v.) or by gavage. The other 14 groups (7 healthy and 7 diabetic) were gavaged with saline every 12 hours for three days and then treated in the same way. Blood samples were collected from the tail vein for 10 hours after the dose and analyzed for blood glucose, serum gliclazide & serum MKC concentrations. Serum concentration-time curves for gliclazide and MKC were used to determine pharmacokinetic parameters. In the parallel ex vivo study (Chapter 4), 88 rats were randomly divided into 22 groups (n=4 rats per group, 8 chambers per rat), of which 11 groups were made diabetic. Of the 22 groups, 8 groups (4 healthy and 4 diabetic) were pretreated with probiotics as described above to study their influence on gliclazide and MKC flux, 8 groups (4 healthy and 4 diabetic) were used to investigate the interaction between gliclazide and MKC during transport, and 6 groups (3 healthy and 3 diabetic) were used to study the influence of selective inhibitors of the drug transporters Mrp2, Mrp3 and Mdr1 on gliclazide flux. 10 cm piece of the ileum was removed from each rat, the underlying muscle layer and connective tissue removed and the epithelial sheets mounted into Ussing chambers. Gliclazide, MKC or a combination were added to either the mucosal or serosal side and samples collected from both sides for 3 h to determine mucosal-to-serosal absorptive flux (Jss[MtoS]) and serosal-to-mucosal secretory flux (Jss[StoM]) of gliclazide and MKC as appropriate. In diabetic rats, gliclazide alone had no effect on blood glucose levels (Ch3, exp2) whereas MKC reduced it from 23 � 3 to 18 � 3 mmol/l (Ch3, exp3) and the combination of gliclazide and MKC reduced it even further from 24 � 4 to 16 � 3 mmol/l (Ch3, exp4). In diabetic rats, probiotic treatment reduced blood glucose by 2-fold (Ch3, exp1) and enhanced the hypoglycemic effect of the combination of gliclazide and MKC (blood glucose decreased from 24 � 3 to 10 � 2 mmol/l). The bioavailability of gliclazide was higher in healthy rats (53.2 � 6.2%) than in diabetic rats (39.9 � 6.0%) (Ch3, exp2). In healthy rats, MKC enhanced gliclazide bioavailability (82.7 � 8.2%) but in diabetic rats MKC had no effect on gliclazide bioavailability (Ch3, exp4). In healthy rats, probiotic pretreatment significantly reduced gliclazide and MKC bioavailabilities (p<0.01) while in diabetic rats, probiotic pretreatment significantly increased the low bioavailability of gliclazide to a level similar to that in healthy rats (Ch3, exp2 & 3). MKC showed clear evidence of enterohepatic recycling and probiotics delayed and reduced its systemic absorption (Ch3, exp3). In ileal tissues from healthy rats, Ussing chamber studies showed gliclazide is most likely a substrate of Mrp2 and Mrp3 (Ch4, exp5) and MKC significantly reduced gliclazide Jss[MtoS] probably through Mrp3 inhibition (Ch4, exp1). In ileal tissue from diabetic rats, MKC had no effect on gliclazide Jss[MtoS] and Jss[StoM] (Ch4, exp2) and none of the inhibitors had any effect of gliclazide flux (Ch4, exp6). This suggests that these transporters are dysfunctional in this model of T1D. Probiotics and MKC have hypoglycemic effects that appear to be enhanced by gliclazide and all appear to interact at the level of ileal drug transporters. The combination of probiotic treatment, gliclazide and MKC exerted the greatest hypoglycemic effect in T1D rats. Accordingly, the application of this combination may have potential in improving the treatment of T1D.
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Peng, Chih-Ting, and 彭稚庭. "Hypoglycemic and hypolipidemic effects of Hedyotis diffusa in streptozotocin-nicotinamide-induced diabetic rats." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/61471649012478893987.

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碩士<br>輔仁大學<br>營養科學系碩士班<br>103<br>Hedyotis diffusa (HD) is a well-known Chinese folk medicine. Previous research has shown that HD has many potentially beneficial health effects including antioxidant, anti-tumor and immunomodulatory activities. Recent studies found that oleanolic acid and ursolic acid, the main phenolic compounds in HD, can reduce blood glucose by inhibiting gluconeogenesis in diabetic rats. Therefore, the present study investigated the hypoglycemic effects of Hedyotis diffusa in streptozotocin-nicotinamide-induced diabetic rats. The HD extracts derived from various solvents (hot water, 50% ethanol and 95% ethanol) were used to inhibit the enzyme activities (including glucose-6-phosphatase, G-6-pase and phosphoenolpyruvate carboxykinase, PEPCK) in gluconeogenesis were assayed. The results showed that HD extracts of 95% ethanol possessed the best inhibitory capacities of key enzymes in gluconeogenesis and therefore was chosen for the subsequent animal experiment. Wistar rats were randomly divided into control group, diabetic group, low- or high-dosage of HD extracts (1%, 3% extracts in diet, respectively) and positive control group (metformin). In addition to control group, rats were induced to develop type 2 diabetes mellitus by intraperitoneal injection of streptozotocin- nicotinamide in combination with high-fat diet. After four weeks, the results showed that ethanol extracts from HD significantly decreased postprandial blood glucose, blood glucose levels after oral glucose tolerance test (OGTT) at the 60th minute, and inhibited enzyme activities in gluconeogenesis, including G-6-Pase, fructose 1,6-bisphosphatase and PEPCK. In addition, diabetic rats treated with HD extracts displayed significantly decreased triacylglycerol, total cholesterol and thiobarbituric acid reactive substances (TBARS) content in serum. In conclusion, the 95% ethanol extracts of HD significantly inhibit enzyme activities in gluconeogenesis in vitro and improve postprandial blood glucose by inhibiting gluconeogenesis and hypolipidemia in type 2 diabetic rats.
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Lin, Wei-Kang, and 林維剛. "Evaluation of the hypoglycemic and hypolipidemic effects of submerged culture of Ganoderma lucidum on type 2 diabetic rats." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/hv3rsk.

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"Pharmacological studies of Ilex latifolia--: hypoglycemic and hypolipidemic effects and lack of acute toxicity of Ilex latifolia extract and its saponin-enriched fraction." 2000. http://library.cuhk.edu.hk/record=b5890309.

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by Fok Ho Yin.<br>Thesis (M.Phil.)--Chinese University of Hong Kong, 2000.<br>Includes bibliographical references (leaves 114-120).<br>Abstracts in English and Chinese.<br>Acknowledgements --- p.ii<br>Abstract --- p.iii<br>槪論 --- p.v<br>List of Abbreviations --- p.vi<br>Chapter Chapter 1 --- Introduction --- p.1<br>Chapter Chapter 2 --- Toxicological studies on the effect of Ilex latifolia extract and its saponin-enriched Fraction --- p.19<br>Chapter Chapter 3 --- Hypoglycemic effect of Ilex latifolia extract and its saponin-enriched fraction --- p.51<br>Chapter Chapter 4 --- Hypolipidemic effect of Ilex latifolia extract and its saponin-enriched fraction --- p.78<br>Chapter Chapter 5 --- Conclusion --- p.109<br>References --- p.114
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Lin, Lan-Chi, and 林蘭砡. "THe Hypolipidemic Effects of Pu-Erh tea." Thesis, 1997. http://ndltd.ncl.edu.tw/handle/93779916365802966659.

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碩士<br>國立臺灣大學<br>食品科技研究所<br>85<br>The Hypolipidemic Effects of Pu-Erh Tea Lan-Chi, Lin. Graduate Institute of Food Science and Technology, National Taiwan University, Taipei, Taiwan, R.O.C. Abstract Pu-Erh tea is a fermented tea produced in the Yunan district in China. Recently, this tea has also gained popularity in Taiwan. In Pu-Erh tea, the bioactive ingredients can be originated from the tea leaves and their transformed products by the endogenous enzymes. Metabolites derived from the fermentation microorganisms such as Aspergillus, and biotransformation products originally derived from tea may also contribute to the potential biological activities of Pu-Erh tea. A previous study has indicated that Pu-Erh tea reduces plasma cholesterol and triacylglycerol in female Wistar rats. Meanwhile, the adrenalin-induced lipolysis is also stimulated, These findings suggest that uptake of Pu-Erh tea may ameliorate hypolipidemia and obiesty. In this study, the potential of an aqueous extract of Pu-Erh tea (PET) on cholesterol biosynthesis in vitro and lipid metabolism in vivo were elucidated With lovastatin as a positive control, the incorporation of 〔2-3H〕acetate and R-〔2-14C〕mevalonic acid into cholesterol by the cultured human hepotoma cells (HepG2) was chosen as the in vitro model to elucidate the potential of PET to inhibite cholesterol synthesis. In animal study, male hamsters and male Spsgue-Dawley rats fed with cholesterol (1.0 %, w/w) were chosen as animal models to elucidate the potential of PET to inhibit hepatic cholesterol synthesis, intestinal cholesterol absorption, and enetrohepatic circulation of bile acids. In vitro syudy showed that PET reduced cholesterol biosynthesis significantly (40 mg/mL PET showed 56 % inhibition) with the action mechanism of PET being similar to that of lovastatin (pre-mevalonate inhibition). In animal models, the results showed that PET inhibited cholesterol biosynthesis when compared to the control group. It is intresting because lovastatin is a product of Aspergillus and Aspergillus has often been found in the preparation of Pu-Erh tea. PET supplemention also reduced hepatic cholesterol content and the levels of serum cholesterol ,TG and FFA (p<0.05). The reduction of serum FFA and elevation of incorporation of isotope labelled acetate into TG in adipose tissue of hamsters suggested that PET stimulated insulin sensitivity. The fecal cholesterol secretion was increased in hamsters and rats fed with 1%, 1.5% and 2% PET. Cholesterol absorption in the intestine is decreased by reducing the solubility of cholesterol in mixed micelles. The finding that PET contained catechins further supported the observations in these two animal models. In comlusion, PET reduced liver cholesterol content and serum levels of cholesterol, TG, FFA. The fecal cholesterol contents were increased. Meanwhile, PET had the effect to inhibit cholesterol biosynthesis in vitro and in vivo.
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Chang, Chun-Kai, and 張淳凱. "Assessment of the Hypolipidemic Effects of Combinatory or Alternative Administration of Various Hypolipidemic Functional food." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/02077795039538737323.

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碩士<br>中原大學<br>生物科技研究所<br>96<br>It has been recognized that many foods containing with some special components which can either reduce risk factors of a disease or enhance health benefits. However, people are very hard to ingest a same health food for years to obtain its benefit. The aim of the study was to investigate can a person eat various foods in a category with same health function, in stead of a same single health food? Eighty hamsters were divided into 8 groups, 8 each, and fed recommended dose of Chlorella-Cryptomonadales, chitosan, oat, fish oil, adlay, a cycle menu of these 5 food items, a mixture of 1/5 recommended doses of these 5 food items or control diet for 6 weeks. Serum lipids were determined after animals were sacrificed. The results showed that all the individual health food, cycle menu or mixture of these health food diets could reduce serum triacylglycerol (TG), total cholesterol (TC), low density lipoprotein-cholesterol (LDL-C) and increase high density lipoprotein-cholesterol (HDL-C), comparing with control group. The results also revealed that there was no difference among the treatment groups, except fish oil group on HDL-C concentrations. The result demonstrated that a people can rotate taking any health food in the same functional category to obtain same health effect, and not necessary to ingest a same one every day.
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Tseng, Chien-Jung, and 曾千容. "The Hypoglycemic Effects of Dioscorea TuberCultivated in Taiwan." Thesis, 2005. http://ndltd.ncl.edu.tw/handle/10485937705147416720.

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碩士<br>高雄醫學大學<br>天然藥物研究所碩士班<br>93<br>Dioscorea tuber has been used in medical treatment and functional food for thousand years. In this study, hypoglycemic activity was detected in polysaccharide-enriched fractions (PLE) and hot water extracts (HWE) of five kinds of Dioscorea tubers cultivated in Taiwan (numbers and origins: TA01: Dioscorea alata L., TA02: D. alata L., TA03: D. alata L. var. purpurea (Roxb.) M. Pouch., TA04: D. persimilis Prain et Burk. and TA05: D. alata L.) using streptozotocin (STZ) induced diabetic mouse/rat models. Animals showing blood glucose levels 250~300 mg/dL 48 h after STZ treatment were selected for study. In STZ-diabetic mice model, treated with HWE of TA01, TA05, and PLE of TA01, TA02, TA05, respectively, for 14 days significantly (p<0.05) lowered the fasting blood glucose levels when compared with the STZ-diabetic mice group. According to the preliminary results, TA01 and TA05 showed the best hypoglycemic effect in those of five cultivated Dioscorea tubers. Furthermore, in STZ-diabetic rats model, glucose concentrations were increased in serum of diabetic animals in comparison to normal and were significantly improved after treatment with 300 mg/kg HWE of TA01、TA05 and 100 mg/kg PLE of TA01、TA05 p.o. for 7 days and 14 days (p＜0.001), respectively. In addition, all test drugs can reduce the productions of malondialdehyde (p＜0.01) and the ratio value of pancreas, kidney, liver weight to the body weight of rats (p＜0.05~p＜0.01). Otherwise, PLE of TA01 and TA05 showed the increasing of glycogen quantity in liver (p＜0.01~p＜0.001), and HWE of TA05 and PLE of TA01, TA05 increased insulin secretion in serum (p＜0.05~p＜0.01). According to the results, the hypoglycemic effect of PLE is better than that of HWE in Dioscorea tuber. Furthermore, TA01 and TA05 showed the best hypoglycemic effect in those of five Dioscorea tubers cultivated in Taiwan. The mechanisms of the hypoglycemic effect on Dioscorea tubers in this study were considered to the ability of increased insulin secretion and then enhanced the bioconversion of glucose to glycogen in the liver. Moreover, decreased levels of lipid peroxidation in Dioscorea tuber indicative of organs protection in diabetic rats. Based on the result of this study, TA01 and TA05 are suggested to be developed as functional food for treatment of diabetes.
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Books on the topic "Hypoglycemic and hypolipidemic effects"

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Miles, Fisher B., and Frier Brian M, eds. Hypoglycaemia in clinical diabetes. John Wiley, 1999.

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Magnússon, Jónas. Secretion and hypoglycemic action of insulin after surgery: Effects of epidural anaesthesia, enteral nutrition and subtotal pancreatectomy. Dept. of Surgery, Lund University, 1989.

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M, Gotto Antonio, and Smith Louis C. 1937-, eds. Drugs affecting lipid metabolism X: Proceedings of the Xth International Symposium on Drugs Affecting Lipid Metabolism, Texas, November 8-11, 1989. Excerpta Medica, 1990.

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Rodolfo, Paoletti, Kritchevsky David 1920-, Holmes William L. 1918-, and Drugs Affecting Lipid Metabolism Meeting (1986 : Florence, Italy), eds. Drugs affecting lipid metabolism. Springer-Verlag, 1987.

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Yi, Sŏg-yong. Yangmul tongtʻae wa yujŏn chŏngbo sanggwansŏng yŏnʼgu: Yangmul taesa hyoso yujŏnhyŏng e ttarŭn kyŏngguyong hyŏltang kanghaje wa cilostazol ŭi yaktonghakchŏk tʻŭksŏng pyŏnhwa yŏnʼgu = Effects of genetic polymorphism of drug metabolizing enzymes on the pharmacokinetics of oral hypoglycemic agents and cilostazol. Sikpʻum Ŭiyakpʻum Anjŏnchʻŏng, 2007.

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Hans-Uwe, Janka, Mehnert H, Standl E, and International Workshop on Macrovascular Disease in Diabetes Mellitus : Pathogenesis and Prevention (1984 : Garmisch-Grainau, Germany), eds. Macrovascular disease in diabetes mellitus: Pathogenesis and prevention : international workshop, Garmisch-Grainau, October 1984. Georg Thieme, 1985.

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Frier, Brian M., Simon Heller, and Rory McCrimmon. Hypoglycaemia in Clinical Diabetes. Wiley & Sons, Incorporated, John, 2013.

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(Editor), Brian M. Frier, and Miles Fisher (Editor), eds. Hypoglycaemia in Clinical Diabetes (Practical Diabetes). 2nd ed. Wiley-Interscience, 2007.

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Fisher, Miles, and Brian M. Frier. Hypoglycaemia in Clinical Diabetes. Wiley & Sons, Incorporated, John, 2007.

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(Editor), Brian M. Frier, and B. Miles Fisher (Editor), eds. Hypoglycemia in Clinical Diabetes (Practical Diabetes). Wiley, 1999.

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Book chapters on the topic "Hypoglycemic and hypolipidemic effects"

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Yilmaz, Mustafa Abdullah, and Oguz Cakir. "Salvia (Sage) Species, a Game-Changer Bioactive Plant: Focus on Antioxidant Properties." In Natural Antioxidants and in Vitro Antioxidant Assays. Nobel Tip Kitabevleri, 2024. http://dx.doi.org/10.69860/nobel.9786053359333.4.

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The demand for natural, health-oriented food additives and components has increased, with plant-based foods rich in phytochemicals like phenolic compounds being beneficial for human health. Salvia species, the largest plant family in the Lamiaceae, contain over nine hundred species, including sage, which has numerous beneficial uses and biological properties. Sage extracts have shown antioxidant, hypoglycemic, hypolipidemic, antitumor, anticholinesterase, antimicrobial, and liver-protective properties. S. officinalis L. has been suggested to have an anti-radical effect against uranium toxicity. Sage essential oil (EO) has antibacterial, antifungal, and free radical scavenging properties. S. miltiorrhiza has been given special attention for treating viral illnesses, with quinoone diterpenes being the most intriguing. Antioxidant activity evaluation techniques have evolved over the past decade, with chemical assays and novel detection technologies replacing earlier approaches. In vitro chemical tests, such as hydrogen atom transfer (HAT) and single electron transfer (SET) procedures, are used to assess antioxidant capacity. Electron transfer (ET) assays measure antioxidant activity by transferring electrons and lower metallic ions, carbonyl groups, and free radicals. Mixed tests (HAT/SET) determine the total antioxidant capacity (TAC) of a compound or extract. In vivo animal experiments are used to assess the antioxidant activity of natural extracts. Future research should focus on sage’s antioxidant properties, its mode of action, and the varying compositions of different species.
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Saha, Aloke, and Somanjana Khatua. "Hypolipidemic and Cholesterol-Lowering Effects of Ganoderma." In Ganoderma. CRC Press, 2024. http://dx.doi.org/10.1201/9781003354789-11.

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Doss, A., P. S. Tresina, and V. R. Mohan. "Medicinal Plants with Hypoglycemic Effects: An Overview." In The Phytochemical and Pharmacological Aspects of Ethnomedicinal Plants. Apple Academic Press, 2021. http://dx.doi.org/10.1201/9781003100768-18.

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Wei, Xiaobo, Yaoran Li, and Boyu Huang. "Hypolipidemic Effects of Flavonoids from Sea Buckthorn Leaves." In Sea Buckthorn. Springer Nature Singapore, 2025. https://doi.org/10.1007/978-981-97-9865-0_8.

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Chen, Haixia, and Yangpeng Lu. "An Overview of Hypoglycemic Modern Drugs." In Structure and Health Effects of Natural Products on Diabetes Mellitus. Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-15-8791-7_2.

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Chen, Haixia, and Qirou Wang. "An Overview of Hypoglycemic Biological Drugs." In Structure and Health Effects of Natural Products on Diabetes Mellitus. Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-15-8791-7_3.

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Chen, Haixia, and Nannan Li. "An Overview of Hypoglycemic Traditional Drugs." In Structure and Health Effects of Natural Products on Diabetes Mellitus. Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-15-8791-7_4.

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Chen, Haixia, and Tingting Zhang. "Isolation and Structure Elucidation of Hypoglycemic Compounds." In Structure and Health Effects of Natural Products on Diabetes Mellitus. Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-15-8791-7_6.

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Karlsson, Finnbogi O., and Alan J. Garber. "Insulin Resistance and Lipoproteins in Hypertriglyceridemia: Effects of Hypolipidemic Drug Treatment." In Drugs Affecting Lipid Metabolism. Springer Netherlands, 1996. http://dx.doi.org/10.1007/978-94-009-0311-1_45.

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Gomaraschi, Monica, Maria Pia Adorni, Maciej Banach, Franco Bernini, Guido Franceschini, and Laura Calabresi. "Effects of Established Hypolipidemic Drugs on HDL Concentration, Subclass Distribution, and Function." In High Density Lipoproteins. Springer International Publishing, 2014. http://dx.doi.org/10.1007/978-3-319-09665-0_19.

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Conference papers on the topic "Hypoglycemic and hypolipidemic effects"

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Indriawati, Ratna, Vitis Vinivera, and Tunjung Wibowo. "Hypoglycemic and Hypolipidemic Effects Red Rosella Flower Steeping on Diabetic Rats." In 4th International Conference on Sustainable Innovation 2020–Health Science and Nursing (ICoSIHSN 2020). Atlantis Press, 2021. http://dx.doi.org/10.2991/ahsr.k.210115.025.

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Li, Chang-Lei, Bao-Miao Ma, Xiao-Qing Chen, Yu-Wei Liu, and Xi-Ji Shu. "Hypoglycemic and Hypolipidemic Effects of Melastoma dodecandrum ethanol-extract on Type 2 Diabetic Rats." In 2015 International Forum on Bioinformatics and Medical Engineering. Atlantis Press, 2015. http://dx.doi.org/10.2991/bme-15.2015.11.

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Li, Changlei, Xiji Shu, Xiaoqing Chen, et al. "Effect of Cortex Lycii Radicis Ethanol-Extract on the Hypoglycemic and Hypolipidemic In Type 2 Diabetic Rats." In 2016 6th International Conference on Applied Science, Engineering and Technology. Atlantis Press, 2016. http://dx.doi.org/10.2991/icaset-16.2016.60.

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Al-Jumaily, Essam Fadel. "Hypoglycemic and Hypolipidemic Effect of Active Compounds (Glucokinin or Plant Insulin) from Bauhina Variegate L. in Alloxan Induced Diabetic Mice." In Qatar Foundation Annual Research Conference Proceedings. Hamad bin Khalifa University Press (HBKU Press), 2016. http://dx.doi.org/10.5339/qfarc.2016.hbpp1898.

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Li, Jian, Shujuan Chen, Ning Liu, Yan Huang, and Xin Liu. "Hypoglycemic and Hypolipidemic Activity of Total Saponins in Cinnamon." In 2010 4th International Conference on Bioinformatics and Biomedical Engineering (iCBBE 2010). IEEE, 2010. http://dx.doi.org/10.1109/icbbe.2010.5516306.

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Zhang, Jin-Xiu, Dan-Dan Gu, Xiao-Jing Zhao, et al. "A Primary Study of the Antioxidant, Hypoglycemic, Hypolipidemic and Antitumor Activities of SLE." In 2015 International Conference on Medicine and Biopharmaceutical. WORLD SCIENTIFIC, 2016. http://dx.doi.org/10.1142/9789814719810_0106.

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Wu, Ming, and Li-Quan Guo. "Hypoglycemic Effects of Polysaccharides from Radix Astragali in Alloxan-Induced Diabetic Mice." In 2015 International Conference on Energy, Environmental & Sustainable Ecosystem Development (EESED 2015). WORLD SCIENTIFIC, 2015. http://dx.doi.org/10.1142/9789814723008_0157.

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Shen, Ruiling, and Fengli Cai. "The Effects of Oat beta-Glucan on the Hypoglycemic of Type 2 Diabetic Mice." In 2010 4th International Conference on Bioinformatics and Biomedical Engineering (iCBBE). IEEE, 2010. http://dx.doi.org/10.1109/icbbe.2010.5516500.

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Fenton-Navarro, B., MA Vargas Vargas, A. Vázquez-Hernández, and L. Torner. "Hypoglycemic and antioxidant effects of oral treatment of Verbesina montanoifolia extract in diabetic rats." In 67th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA) in cooperation with the French Society of Pharmacognosy AFERP. © Georg Thieme Verlag KG, 2019. http://dx.doi.org/10.1055/s-0039-3400044.

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Altaee, Muddather, Samaraa Youns, Abdullah Al-Nuaymia, Sara Dabdob, and Muhammad Alkataan. "The Protective Effects of a Phenolic Clove Extract on Mitochondria: An Animal Study." In 5th International Conference on Biomedical and Health Sciences. Cihan University-Erbil, 2024. http://dx.doi.org/10.24086/biohs2024/paper.1201.

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Background: Plants represent a treasure chest with many unrevealed medical applications that have made them traditionally used for thousands of years to treat different diseases. One of these applications is the hypoglycemic and antioxidant roles of some plants. A pathological condition characterized by hyperglycemia, insulin resistance, and dyslipidemia known as metabolic syndrome. Objectives: This work focuses on examining the hypoglycemic effect of Syzygium aromaticum on a metabolic syndrome-induced animal model and studying the role of the extracted phenolic compounds on different mitochondrial function genomic parameters. Methods: Sánchez-Rangel et al. (2013) described the extraction and quantification of phenolic components from Syzygium aromaticum using the Folin-Ciocalteu reagent. In this work, forty albino rats were involved. They were split up into the following four groups, each consisting of five animals: Syzygium aromaticum treatment for metabolic syndrome, non-metabolic syndrome animals treated with Syzygium aromaticum, and negative control (normal), positive control (metabolic syndrome produced with fructose without treatment). Serum glucose, pyruvate, lactate, lipid profile, liver function tests, and molar lactate/pyruvate ratio. Green and red mitotrackers are used to measure the mass and action potential of mitochondria. Results: According to the study's findings, clove extract dramatically lowers blood sugar levels in rats with metabolic syndrome. The plants return serum lactate, pyruvate, and molar lactate: pyruvate ratio to normal control negative values. Mitochondrial mass and action potential significantly improve after treatment. In comparison to metabolic syndrome animals, the mitochondrial copy number of peripheral blood cells significantly increases after treatment with the plant extract. Conclusion: Metabolic syndrome significantly reduces mitochondrial genome copies number. The application of the phenolic extract of Syzygium aromaticum.
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Reports on the topic "Hypoglycemic and hypolipidemic effects"

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Arista-Ugalde, Taide Laurita, Sebastián Delgado Arroyo, Graciela Gavia-García, et al. Hypoglycemic effects of Sechium edule. A systematic review and meta-analysis of clinical and preclinical trials. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, 2025. https://doi.org/10.37766/inplasy2025.4.0025.

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Song, Ruirui, Hongmei Gao, Fang Liu, Jun Chen, and Xiaojing Shi. Effects of new hypoglycemic drugs on patients with heart failure: a systematic review and network meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, 2023. http://dx.doi.org/10.37766/inplasy2023.9.0031.

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Yibchok-anun, Sirintorn, Sophon Roengsumran, and H. Hsu, Walter. Protein extract from fruit pulp of Siamese momordica charantia with insulin secretagogue and insulin-like activities. Chulalongkorn University, 2004. https://doi.org/10.58837/chula.res.2004.84.

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The aim of this study was to investigate the effects of zinc-free protein extract from bitter gourd fruit pulp on plasma glucose concentration and insulin responses in normal and STZ-induced diabetic rats. Furthermore, we investigated the direct effect of the MC protein extract on insulin and glucagons secretions from the perfused rat pancreas as well as glucose uptake in C2C12 rat myocytes and 3T3-L1 rat adipocytes. The protein from Thai bitter gourd (Momordica charantia) fruit pulp was extracted and studied for its hypoglycemic effect. Subcutaneous administration of the protein extract (5 and 10 mg/kg) significantly and markedly decreased plasma glucose concentrations in both normal and streptozotocin-induced diabetic rats in a dose-dependent manner. The onset of the protein extract-induced antihyperglycemia/hypoglycemia was observed at 4 and 6 h in diabetic and normal rats, respectively. This protein extract also raised plasma insulin concentrations by 2 fold 4 h following subcutaneous administration. In perfused rat pancreas, the protein extract (10 [M]g/ml) increased insulin secretion, but not glucagons secretion, which was apparent within 5 min of administration and was persistent during 30 min of administration. Furthermore, the protein extract enhanced glucose uptake into C2C12 myocytes and 3T3-L1 adipocytes. Thus, the M. charantia protein has both insulin secretagogue and insulin-like activities that could help explain its hypoglycemic effect in vivo.
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