Journal articles: 'Hypoglycemic and hypolipidemic effects'

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Abousamra, Mona M., Mona Basha, Sally El Awdan та Nasser S. M. Ismail. "EFFECT OF METHYL-Β-CYCLODEXTRIN COMPLEXATION ON THE HYPOGLYCEMIC AND HYPOLIPIDEMIC EFFECTS OF KHELLIN: EXPERIMENTAL STUDY". International Journal of Pharmacy and Pharmaceutical Sciences 8, № 11 (2016): 165. http://dx.doi.org/10.22159/ijpps.2016v8i11.14365.

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Objective: The present work tackled the development and evaluation of inclusion complex of khellin (KH) and methyl-β-cyclodextrin (MβCD). In addition, it tested its possible hypoglycemic and hypolipidemic effects.Methods: Inclusion complexes of KH-MβCD in the presence of water-soluble polymer were prepared by freeze drying (FD), co-evaporation (EV) and kneading methods (KN). The selected ternary complex was characterized by Fourier transform infrared spectrophotometry (FTIR), x-ray diffractometry (XRD), differential scanning calorimetry (DSC) and scanning electron microscopy [1]. Assessment of the hypoglycemic effect of the selected ternary complex versus the standard drug metformin was studied. Two different doses of the ternary complex were administered orally to streptozotocin (STZ)-induced type 2diabetic rats. Their hypoglycemic and hypolipidemic effects were evaluated by measuring the fasting blood glucose level (BGL), total cholesterol (TC) and triglycerides levels (TG) along the study period.Results: The FD complex showed the highest drug dissolution rate. All the performed characterization analysis confirmed the formation of a KH-MβCD inclusion complex. The in vivo study declared that both doses showed a marked hypoglycemic and hypolipidemic effects compared to metformin.Conclusion: In conclusion, this study points for the first time that the complexation of KH with MβCD could notably improve the dissolution rate and hence the bioavailability of KH. Moreover, this study demonstrated that this compound has a hypoglycemic and hypolipidemic effect. Thus, it can be a promising natural supportive treatment in type 2 diabetes mellitus (T2DM).

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Joseph, P. K., and R. T. Kasinath. "Hypoglycemic and hypolipidemic effects of diacetodibutyl disulphide." Indian Journal of Clinical Biochemistry 15, no. 2 (2000): 68–75. http://dx.doi.org/10.1007/bf02883731.

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Wang, Kaiping, Peng Cao, Weizhi Shui, Qiuxiang Yang, Zhuohong Tang, and Yu Zhang. "Angelica sinensis polysaccharide regulates glucose and lipid metabolism disorder in prediabetic and streptozotocin-induced diabetic mice through the elevation of glycogen levels and reduction of inflammatory factors." Food & Function 6, no. 3 (2015): 902–9. http://dx.doi.org/10.1039/c4fo00859f.

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Habib, M. Anwar, ASM Anisuzzaman, RK Barman, M. Abdul Gafur, and M. Tofazzal Haque. "Isolation and Characterization of Hypolipidemic Compound from Cajanus cajan." TAJ: Journal of Teachers Association 24, no. 1 (2011): 6–10. http://dx.doi.org/10.3329/taj.v24i1.37441.

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The study was carried out to identify the compound responsible for hypolipidemic and hypoglycemic effects of Cajanus cajan (redgram). The methanol extract of redgram seeds was found to decrease fasting blood glucose and lipid profile (p<0.001) on streptozotocin-induced mice compared to control. This activity- guided fraction led to the isolation of a compound, substituted benzene containing polyhydroxy functions fused with lactone (CCA3) by analysis of 1H and 13C-NMR data. Biological studies of the isolated compound possessed prominent hypolipidemic activity. Although a number of hypoglycemic compounds are reported, yet not any hypolipidemic compound from redgram. The compound CCA3 seems to be the first report on hypolipidemic activity from methanol extract of redgram. TAJ 2011; 24(1): 6-10

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Tu, Lanlan, Rui Wang, Zheng Fang, et al. "Assessment of the Hypoglycemic and Hypolipidemic Activity of Flavonoid-Rich Extract from Angelica keiskei." Molecules 27, no. 19 (2022): 6625. http://dx.doi.org/10.3390/molecules27196625.

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Angelica keiskei contains a variety of bioactive compounds including chalcone, coumarin, and phytochemicals, endowing it with pharmacological effects such as lipid-lowering activity, antitumor activity, liver protection, and nerve protection. This study aims to study the hypoglycemic and hypolipidemic effects of the flavonoid-rich extract from Angelica keiskei (FEAK) in an effort to exploit new applications of FEAK and increase its commercial value. In this paper, flavonoid compounds in Angelica keiskei were extracted using 50% ethanol, and the contents of the flavonoid compounds were analyzed by UPLC-MS/MS. Then, the hypoglycemic and hypolipidemic activities of the FEAK were investigated through in vitro enzyme activity and cell experiments as well as establishing in vivo zebrafish and Caenorhabditis elegans (C. elegans) models. The UPLC-MS/MS results show that the major flavonoid compounds in the FEAK were aureusidin, xanthoangelol, kaempferol, luteolin, and quercetin. The inhibitory rates of the FEAK on the activity of α-amylase and cholesterol esterase were 57.13% and 72.11%, respectively. In cell lipid-lowering experiments, the FEAK significantly reduced the total cholesterol (TC) and total triglyceride (TG) levels in a dose-dependent manner, with 150 μg/mL of FEAK decreasing the intracellular levels of TC and TG by 33.86% and 27.89%, respectively. The fluorescence intensity of the FEAK group was 68.12% higher than that of the control group, indicating that the FEAK exhibited hypoglycemic effects. When the concentration of the FEAK reached 500 μg/mL, the hypoglycemic effect on zebrafish reached up to 57.7%, and the average fluorescence intensity of C. elegans in the FEAK group was 17% lower than that of the control group. The results indicate that the FEAK had hypoglycemic and hypolipidemic activities. The findings of this study provide theoretical references for the high-value utilization of Angelica keiskei and the development of natural functional food with hypoglycemic and hypolipidemic activities.

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Zhou, Ji-Yin, Shi-Wen Zhou, Sheng-Ya Zeng, Jian-Yun Zhou, Ming-Jin Jiang, and Yan He. "Hypoglycemic and Hypolipidemic Effects of Ethanolic Extract ofMirabilis jalapaL. Root on Normal and Diabetic Mice." Evidence-Based Complementary and Alternative Medicine 2012 (2012): 1–9. http://dx.doi.org/10.1155/2012/257374.

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The present study investigated the insulin sensitivity, hypoglycemic, and hypolipidemic activities of ethanolic extract ofMirabilis jalapaL. root (EEM) in normal and diabetic mice. After induction of diabetes with streptozotocin, both normal and diabetic mice were singly or repeatedly for 28 days administrated with EEM at doses of 2, 4, 8 g/kg, respectively. Before induction of diabetes, mice were administrated with EEM at doses of 2, 4, 8 g/kg for 14 days and were injected with streptozotocin and continued on EEM administration for another 28 days. Both after and before induction of diabetes, repeated administration with 4, 8 g/kg EEM continually lowered blood glucose level, decreased serum insulin level and improved insulin sensitivity index, and lowered serum total cholesterol, triglyceride levels and triglyceride content in liver and skeletal muscle, and increased glycogen content in these tissues; but repeated administration had no influence on those indexes of normal mice. Single administration with EEM (4, 8 g/kg) showed hypoglycemic effect in oral glucose tolerance test in normal and diabetic mice. Single administration with EEM had no hypoglycemic and hypolipidemic effects on normal and diabetic mice. These results suggest that EEM possesses both potential insulin sensitivity, hypoglycemic, and hypolipidemic effects on diabetes.

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Xu, Jialin, Tingting Liu, Yuanyuan Li, et al. "Hypoglycemic and hypolipidemic effects of triterpenoid-enriched Jamun (Eugenia jambolana Lam.) fruit extract in streptozotocin-induced type 1 diabetic mice." Food & Function 9, no. 6 (2018): 3330–37. http://dx.doi.org/10.1039/c8fo00095f.

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Jia, Sheng, Ying Hu, Wenna Zhang, et al. "Hypoglycemic and hypolipidemic effects of neohesperidin derived from Citrus aurantium L. in diabetic KK-Aymice." Food & Function 6, no. 3 (2015): 878–86. http://dx.doi.org/10.1039/c4fo00993b.

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Chen, Zhongqin, Cong Wang, Yuxiang Pan, Xudong Gao, and Haixia Chen. "Hypoglycemic and hypolipidemic effects of anthocyanins extract from black soybean seed coat in high fat diet and streptozotocin-induced diabetic mice." Food & Function 9, no. 1 (2018): 426–39. http://dx.doi.org/10.1039/c7fo00983f.

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Yang, Chang, Qi Feng, Huan Liao, Xinlei Yu, Yang Liu та Di Wang. "Anti-Diabetic Nephropathy Activities of Polysaccharides Obtained from Termitornyces albuminosus via Regulation of NF-κB Signaling in db/db Mice". International Journal of Molecular Sciences 20, № 20 (2019): 5205. http://dx.doi.org/10.3390/ijms20205205.

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Termitornyces albuminosus is a kind of traditional Chinese edible fungus rich in nutrients and medicinal ingredients, and it has anti-oxidative, analgesic and anti-inflammatory effects. However, the hypoglycemic and nephroprotective effects of polysaccharides separated from T. albuminosus (PTA) have not been reported. The properties of PTA were analyzed in a BKS.Cg-Dock7m +/+ Leprdb/JNju (db/db) mouse model of diabetes. After the administration of PTA for eight weeks, the hypoglycemic and hypolipidemic activities of PTA in the db/db mice were assessed. The results of a cytokine array combined with an enzyme-linked immunosorbent assay confirmed the anti-oxidative and anti-inflammatory activities of PTA. An eight-week administration of PTA caused hypoglycemic and hypolipidemic functioning, as indicated by suppressed plasma glucose levels, as well as the modulation of several cytokines related to glycometabolism, in the sera and kidneys of the mice. PTA treatment also had a protective effect on renal function, restoring renal structures and regulating potential indicators of nephropathy. In the kidneys of the db/db mice, PTA treatment reduced the activation of protein kinase B, the inhibitor of κB kinase alpha and beta, and the inhibitor of κB alpha and nuclear factor-κB (NF-κB). We establish the hypoglycemic, hypolipidemic, and anti-diabetic nephropathy effects of PTA, and we find that the renal protection effects of PTA may be related to anti-inflammatory activity via the regulation of NF-κB signaling.

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Ou, Juanying, Junqing Huang, Danyue Zhao, Bin Du, and Mingfu Wang. "Protective effect of rosmarinic acid and carnosic acid against streptozotocin-induced oxidation, glycation, inflammation and microbiota imbalance in diabetic rats." Food & Function 9, no. 2 (2018): 851–60. http://dx.doi.org/10.1039/c7fo01508a.

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Pothuraju, Ramesh, Raj Kumar Sharma, Suneel Kumar Onteru, Satvinder Singh, and Shaik Abdul Hussain. "Hypoglycemic and Hypolipidemic Effects ofAloe veraExtract Preparations: A Review." Phytotherapy Research 30, no. 2 (2015): 200–207. http://dx.doi.org/10.1002/ptr.5532.

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Schneider, Mariane, Adrieli Sachett, Amanda P. Schönell, et al. "Hypoglycemic and hypolipidemic effects of Solidago chilensis in rats." Revista Brasileira de Farmacognosia 25, no. 3 (2015): 258–63. http://dx.doi.org/10.1016/j.bjp.2015.05.001.

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Liu, Yangyang, Chaorui Wang, Jinshan Li, Yuxia Mei, and Yunxiang Liang. "Hypoglycemic and Hypolipidemic Effects of Phellinus Linteus Mycelial Extract from Solid-State Culture in A Rat Model of Type 2 Diabetes." Nutrients 11, no. 2 (2019): 296. http://dx.doi.org/10.3390/nu11020296.

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Hypoglycemic and hypolipidemic effects of P. linteus have been observed in numerous studies, but the underlying molecular mechanisms are unclear. In this study, we prepared P. linteus extract (PLE) from mycelia of solid-state culture, and evaluated its hypoglycemic and hypolipidemic effects in rat models of high-fat diet (HFD)-induced and low-dose streptozotocin (STZ)-induced type 2 diabetes. PLE treatment effectively reduced blood glucose levels, and improved insulin resistance and lipid and lipoprotein profiles. The hypoglycemic effect of PLE was based on inhibition of key hepatic gluconeogenesis enzymes (FBPase, G6Pase) expression and hepatic glycogen degradation, and consequent reduction of hepatic glucose production. PLE also: (i) enhanced expression of CPT1A and ACOX1 (key proteins involved in fatty acid β-oxidation) and low-density lipoprotein receptor (LDLR) in liver, thus promoting clearance of triglycerides and LDL-C; (ii) inhibited expression of 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) in liver, thus reducing cholesterol production; (iii) displayed strong hepatoprotective and renal protective effects. Our findings indicate that PLE has strong potential functional food application in adjuvant treatment of type 2 diabetes with dyslipidemia.

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Sovia, E., W. Ratwita, D. Wijayanti, and D. R. Novianty. "HYPOGLYCEMIC AND HYPOLIPIDEMIC EFFECTS OF ANNONA MURICATA L. LEAF ETHANOL EXTRACT." International Journal of Pharmacy and Pharmaceutical Sciences 9, no. 3 (2017): 170. http://dx.doi.org/10.22159/ijpps.2017v9i3.16402.

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Objective: The aim of this study was to investigate hypoglycemic and hypolipidemic effects of Annona muricata leaf ethanol extract. This study also investigated phytochemical analysis of the extract and improvement in the islet of Langerhans.Methods: Hypoglycemic and hypolipidemic effects were evaluated using alloxan induced diabetic rats. Twenty-five Wistar rats devided into five groups, that are normal group, control group that induced by alloxan 125 mg/kg body weight and given CMC (carboxymethyl cellulose), and three treatment group that induced by alloxan and given Annona muricata leaf ethanol extract (AMLEE) with 50, 100 and 200 mg/kg body weight. Blood glucose and total cholesterol levels were measured before and after alloxan induction, and 21 d after AMLEE treatment. At the end of the study, all of the animals experiment were sacrificed for histopathological examination.Results: Phytochemical analysis revealed that flavonoids, tannins, saponins, phytosterols and phenols were present in ethanol extract of Annona muricata L. leaf. At the end of the study, blood glucose and total cholesterol levels in all AMLEE treated group were decreased significantly (p<0.05). Final blood glucose level in the groups that given AMLEE 50 mg/kg body weight (86.7±14.6 mg/dl) was almost the same with that of the normal group (91.25±28.38 mg/dl). The result of the histopathological examination is not showed an improvement of the islet of Langerhans in AMLEE treated groups.Conclusion: In conclusion, the ethanol extract of Annona muricata L. leaf have hypoglycemic and hypolipidemic effects. However, there was no improvement in the islet of Langerhans damage.

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Wang, Yong, Haiying Wang, and Fengzhen Yang. "Barbaloin Treatment Contributes to the Rebalance of Glucose and Lipid Homeostasis of Gestational Diabetes Mellitus Mice." Dose-Response 18, no. 4 (2020): 155932582098491. http://dx.doi.org/10.1177/1559325820984910.

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Aloe vera L has been shown to possess hypoglycemic and hypolipidemic effects on type 2 diabetic patients, and its major benefits may be linked to barbaloin, which is a major component of Aloe vera L. This study focused on investigating the potential effects and underlying mechanisms of barbaloin on gestational diabetes mellitus (GDM). The db/+ diabetic mice with GDM were daily orally administered with barbaloin or metformin during the gestational period. The results demonstrated that administration of barbaloin significantly reduced blood glucose levels and increased insulin levels in GDM mice. We further found that barbaloin treatment reduced inflammatory response and ROS levels in the liver. Finally, we revealed that the AMP-activated protein kinase (AMPK) / peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) signaling pathway was involved in BAT-mediated beneficial effects on mice with GDM. Our study suggested that barbaloin exerted hypoglycemic and hypolipidemic effects on GDM mice, via, at least in part, modulation of AMPK/ PGC-1α signaling in GDM mice.

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Zhang, Xiaoqian, Jing Fang, Ruipeng Ge, et al. "Regulation of Glucolipid Metabolism in Mice Using Dendrobium huoshanense Extract and PI3k/Akt Signaling Pathway Activation." Journal of Food Biochemistry 2023 (October 31, 2023): 1–12. http://dx.doi.org/10.1155/2023/8878821.

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The present research is carried out to study the hypoglycemic and hypolipidemic effects of the Dendrobium huoshanense C. Z. Tang et S. J. Cheng extract on type 2 diabetic mice. D. huoshanense extract was prepared using the condensation reflux method. The chemical components were separated by UPLC Triple-TOF MS/MS to further identify the components that mainly exerted hypoglycemic and hypolipidemic effects. Type 2 diabetic C57BL/6 mice were induced by a high-fat diet (HFD) followed by intraperitoneal streptozotocin (STZ) and were daily gavaged with different doses of D. huoshanense extract for 5 weeks. Various methods such as HE staining, ELISA, and Western blot were used to evaluate the hypoglycemic and hypolipidemic effects of D. huoshanense extract on mice with type 2 diabetes mellitus model. The experimental results revealed that the main compounds of D. huoshanense extract were polysaccharides, flavonoids, alkaloids, amino acids, and many other chemical components. Oral administration of 200 mg/kg of the extract of D. huoshanense significantly reduced blood glucose and insulin levels of high-dose group mice and lowered total cholesterol (TC), triglyceride (TG), and low-density lipoprotein cholesterol (LDL-C) levels, but increased high-density lipoprotein cholesterol (HDL-C) levels and liver glycogen content. In addition, the protein expression levels of insulin receptor (Ins R), phosphatidylinositol-3 kinase (PI3K) and p-protein kinase B (Akt) were upregulated. These results imply that the D. huoshanense aqueous extract can improve insulin resistance and lipid metabolism in type 2 diabetic mice, and it may regulate the function through the PI3K/AKT pathway.

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Al Mouslem, Abdulaziz K. "Antidiabetic and Hypolipidemic Potentials of Extract of Picris Babylonica in Streptozotocin-Induced Diabetic Model in Rats." Biomedical and Pharmacology Journal 15, no. 1 (2022): 261–67. http://dx.doi.org/10.13005/bpj/2362.

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Objectives: To investigate the hypoglycemic and hypolipidemic potentials of Picris babylonica extract in streptozotocin (STZ) induced diabetes in rats. Methods: Animals were injected with 40mg/kg of STZ to induce diabetes, a common diabetic model. Development of the disease were assessed by measuring blood glucose level 3 days prior systemic administration of STZ and following STZ injection. Animals received 200mg/kg and 400mg/kg of Picris babylonica extract and 0.6mg/kg of glibenclamide, standard, by oral rout for 14 consecutive days. Results: Administration of the Picris babylonica extract significantly decreased serum blood glucose, total cholesterol, triglycerides, and low-density lipoprotein-cholesterol. In addition, high density lipoprotein-cholesterol level significantly enhanced as compared to standard. Conclusion: Picris babylonica extract demonstrated beneficial effects in lowering blood glucose and improving lipid profile, therefore, Picris babylonica extract could be developed as hypoglycemic and hypolipidemic therapy.

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Rasool, Shahid, Bassam Al Meslmani, and Muaaz Alajlani. "Determination of Hypoglycemic, Hypolipidemic and Nephroprotective Effects of Berberis Calliobotrys in Alloxan-Induced Diabetic Rats." Molecules 28, no. 8 (2023): 3533. http://dx.doi.org/10.3390/molecules28083533.

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Many plants of the Berberis genus have been reported pharmacologically to possess anti-diabetic potential, and Berberis calliobotrys has been found to be an inhibitor of α-glucosidase, α-amylase and tyrosinase. Thus, this study investigated the hypoglycemic effects of Berberis calliobotrys methanol extract/fractions using in vitro and In vivo methods. Bovine serum albumin (BSA), BSA–methylglyoxal and BSA–glucose methods were used to assess anti-glycation activity in vitro, while in vivo hypoglycemic effects were determined by oral glucose tolerance test (OGTT). Moreover, the hypolipidemic and nephroprotective effects were studied and phenolics were detected using high performance liquid chromatography (HPLC). In vitro anti-glycation showed a significant reduction in glycated end-products formation at 1, 0.25 and 0.5 mg/mL. In vivo hypoglycemic effects were tested at 200, 400 and 600 mg/kg by measuring blood glucose, insulin, hemoglobin (Hb) and HbA1c. The synergistic effect of extract/fractions (600 mg/kg) with insulin exhibited a pronounced glucose reduction in alloxan diabetic rats. The oral glucose tolerance test (OGTT) demonstrated a decline in glucose concentration. Moreover, extract/fractions (600 mg/kg) exhibited an improved lipid profile, increased Hb, HbA1c levels and body weight for 30 days. Furthermore, diabetic animals significantly exhibited an upsurge in total protein, albumin and globulin levels, along with a significant improvement in urea and creatinine after extract/fractions administration for 42 days. Phytochemistry revealed alkaloids, tannins, glycosides, flavonoids, phenols, terpenoids and saponins. HPLC showed the presence of phenolics in ethyl acetate fraction that could be accountable for pharmacological actions. Therefore, it can be concluded that Berberis calliobotrys possesses strong hypoglycemic, hypolipidemic and nephroprotective effects, and could be a potential therapeutic agent for diabetes treatment.

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Dewi, Sri Hartati Candra, Chatarina Wariyah, and Niken Astuti. "Efek hipoglikemik dan hipolipidemik dendeng daging itik curing dengan ekstrak kurkumin kunyit pada Tikus Wistar." Livestock and Animal Research 19, no. 3 (2021): 301. http://dx.doi.org/10.20961/lar.v19i3.48708.

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Objective: This research aimed to determine hypoglycemic and hypolipidemic effects of cured duck meat jerky with curcumin using male Wistar rats as experimental animals.Methods: This research involved a completely randomized design in oneway pattern with 4 treatments on diabetic (TD) and hyperlipidemic (HD) rats : zero jerky (standard feed, PS), low jerky 0.96 g/head/day (DR), high jerky 1.91g/head/day (DT) and vitamin E 28.80 mg/head/day as control antioxidants (equivalent to 400 IU tocopherol). There were 24 rats divided into 4 treatments for hypoglycemic and hypolipidemia each. The treatment spanned 4 weeks, with hypoglycemic parameters (body weight and blood glucose) observed every week, and hypolipidemic (total cholesterol, triglycerides, HDL, and LDL). Furthermore, an analysis of variance was conducted to determine body weight. When a significant difference was observed, it was continued with Duncan's New Multiples Range Test, while other parameters were analyzed descriptively.Results: The hypoglycemic effect showed a significant difference in body weight where the PS treatment were relatively stable, while DT and vitamin E treatment experienced the highest weight loss. Blood glucose also decreased with the increasing addition of curcumin and vitamin E. Meanwhile, the hyperlipidemic showed a decrease in cholesterol, triglycerides, and LDL, while HDL increased as the concentration of curcumin from jerky increased, the amount of which was equivalent to antioxidant control of vitamin E.Conclusions: The diet of cured duck meat jerky as much as 1.91g/head/day (equivalent to 106.26 g/person/day or 400 IU tocopherol/vitamin E) can lower diabetic blood glucose and improve blood lipid profile.

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R, Ahmed, Jeyabalan G, and Goyal PK. "Evaluation of Hypo-glycemic and Anti-oxidant Potential of Caesalpinia sappan Leave in STZ Induced Diabetic Rats." INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY 14, no. 04 (2024): 945–47. https://doi.org/10.25258/ijddt.14.4.2.

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In southern Asia, including India, Sri Lanka, and other countries, the stem bark, root, and leaves of Caesalpinia Sappan (Fabaceae) have been utilized in traditional medical systems to cure diabetes and numerous other illnesses. The hypoglycemic and hypolipidemic potential of this valued plant's leaves and bark, however, has not yet been proven by science. The current study's objective is to assess the hypoglycemic and hypolipidemic effects of Caesalpinia Sappan leaf ethanol extracts. Hydro-alcoholic extracts in dose 200mg/kg of Caesalpinia Sappan leaves (CSL) was evaluated for hypo-glycemic effect by In vitro α-amylase & α-glucosidase anti-diabetic potential similarly in vivo by using animals for 21 days in addition to the hypolipidemic potential in rats with diabetes induced by streptozotocin.The α-amylase & α-glucosidase inhibition activity was enhanced with enhanced in the concentration of extract. On administration of CSL it restored the body and organs weight. Similarly When CSL extracts were given to diabetic animal as supplements; the levels of GlyHb and plasma glucose were recovered, while insulin, C-peptide, and Hb parameters increased. In the current investigation, MDA levels were shown to be elevated; however, these levels were considerably decreased on the addition of glibenclamide and the hydro-ethanolic extract of CSL.The presence of active principles in the extract and fractions could be the cause of the observed outcome. In comparison to glibenclemide, the usual medication, the results demonstrated the potential effects of Caesalpinia Sappan leaves extract as hypoglycemic and anti-hyperlipidemic in a dose-dependent manner. Scientific evidence supports the traditional usage of this substance as an anti-diabetic.

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Pei, Fangyi, Yuze Lv, Xinbo Cao, Xuemeng Wang, Yanxin Ren, and Jingping Ge. "Structural Characteristics and the Antioxidant and Hypoglycemic Activities of a Polysaccharide from Lonicera caerulea L. Pomace." Fermentation 8, no. 9 (2022): 422. http://dx.doi.org/10.3390/fermentation8090422.

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In this study, a novel polysaccharide, LPP, was obtained from Lonicera caerulea L. pomace by ultrasonic-assisted heating and was purified by Sephadex G-100. The structural characteristics of LPP showed that the molecular weight (Mw) was 8.53 × 104 Da; that it was mainly composed of galacturonic acid, followed by galactose; that it possessed the characteristic functional groups of polysaccharides; and that it had an absence of O-glycosidic bonds and crystalline and triple helix structures. Furthermore, LPP exhibited a favorable thermodynamic stability and antioxidant, hypoglycemic, and hypolipidemic activities in a dose-dependent manner in vitro, demonstrating that LPP can be used as an agent to regulate glycolipid metabolism. Additionally, the relationship between its bio-activities is discussed in this paper. The results revealed that the RP, •OH, and NO2− radicals had synergistic promoting effects, and polysaccharides with a strong antioxidant ability may have excellent hypoglycemic and hypolipidemic effects. Collectively, these results suggest that LPP has a strong bio-activity, and that Lonicera caerulea L. pomace can be used as a potential polysaccharide source.

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Zhao, Rong, Rui Jin, Yong Chen, and Feng-mei Han. "Hypoglycemic and Hypolipidemic Effects of Lycium barbarum Polysaccharide in Diabetic Rats." Chinese Herbal Medicines 7, no. 4 (2015): 310–15. http://dx.doi.org/10.1016/s1674-6384(15)60057-0.

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Al Ani, Khudhair A. M. Abed, and Duraid A. Abbas. "Evaluation of the Effect of Bromocriptine and Sitagliptin and Their Combination on Lipid Profile and Inflammatory Parameters in Induced Type 2 Diabetes Mellitus (T2DM) in Male Albino Rat." INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY 12, no. 03 (2022): 1422–27. http://dx.doi.org/10.25258/ijddt.12.3.82.

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The current study aimed to investigate the hypolipidemic and anti-inflammatory effects of recently used hypoglycemic drugs bromocriptine and sitagliptine alone and combined dosing regimen on induced type 2 diabetes mellitus (T2DM) in albino rats. Forty adult male rats divided equally into five groups including four diabetic groups and one non-diabetic representing control negative.

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Ogechukwu Celestina Iloka, Chinecherem Christiana Maduka, Chidimma Ozoemena Nweke, and Rebecca Nkiru Sampson. "Phytochemical composition, acute toxicity, hypoglycemic and hypolipidemic effects of ethanol extract of Allium sativum (garlic) bulb in male Wistar rats." World Journal of Advanced Research and Reviews 20, no. 2 (2023): 144–56. http://dx.doi.org/10.30574/wjarr.2023.20.2.1984.

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Allium sativum (garlic) has been used in traditional medicine in Nigeria in the treatment of various ailments such as cold, cough, and microbial infections; and there have been various claims about its pharmacological activities including anti-inflammatory, antimicrobial, hypoglycemic, hypolipidemic, antioxidant, antidiabetic, and anticancer properties. However, there are insufficient data to back up these claims. It is against this backdrop, this study evaluated the phytochemical composition, acute toxicity, hypoglycaemic and hypolipidemic potentials of ethanol extract of A. sativum bulb in male Wistar rats in order to validate its therapeutic use as hypoglycaemic and hypolipidemic agent. Twenty adult male Wistar rats were randomly divided into four groups of five rats each where group 1 (control) received normal saline while group 2-4 received the extract at the doses of 200, 400, and 1000mg/kg b.w respectively for fourteen days. T-test and one-way ANOVA were used to test for significant (p<0.05) differences among the groups. Qualitative and quantitative phytochemical screening of the extract indicated the presence of flavonoids (17.59±0.01), saponins (13.55±0.01), alkaloids (2.06±0.06), tannins (0.04±0.00), phenols (0.01±0.00), phlobatanin, phytosterols and terpenoids whereas steroids, anthraquinones and glycosides were not detected. The administration of the extract produced a significant (P<0.05) decrease in the blood glucose concentration in the treatment groups compared to the control group, whereas a significant (P<0.05) decrease was observed in the total cholesterol concentration of group 4 only relative to the control. Furthermore, there was a significant (P<0.05) increase in the HDL concentrations and a significant (P<0.05) decrease in the triglycerides and LDL concentrations respectively in all treatment groups compared to the control group. From these findings therefore, we conclude that A. sativum offers both hypoglycemic and hypolipidemic effects in male Wistar rats.

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Le, Minh Hoang, Huyen Sanh Sam, Duy Toan Pham, Ngoc Chi Lan Nguyen, Ngoc Diem Le, and Tran Nhat Phong Dao. "Ngu-Vi-Tieu-Khat decoction, a Vietnamese traditional medicine, possesses hypoglycemic and hypolipidemic effects on streptozotocin-induced type-2 diabetic rat model." Pharmacia 70, no. 4 (2023): 943–50. http://dx.doi.org/10.3897/pharmacia.70.e108879.

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This study aims to assess the hypoglycemic effects of Ngu-Vi-Tieu-Khat (NVTK) decoction, a traditional Vietnamese medicine, in a rat model of type-2 diabetes. The NVTK decoction was prepared using the maceration method and tested for its hypoglycemic effects by measuring blood glucose levels, insulin resistance indicators, and pancreatic mass. The results showed that NVTK decoction improved diabetes symptoms, increased insulin levels, reduced insulin resistance, restored pancreatic mass, and decreased total cholesterol (TC), triglycerides (TG) and low-density lipoprotein cholesterol (LDL-C) while increasing high-density lipoprotein cholesterol (HDL-C). The hypoglycemic effects of NVTK were comparable to those of gliclazide at a dose of 10 mg/kg. In conclusion, NVTK decoction possesses hypoglycemic properties and could be explored as a potential traditional medicine for treating type-2 diabetes in humans.

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Le, Minh Hoang, Huyen Sanh Sam, Duy Toan Pham, Ngoc Chi Lan Nguyen, Ngoc Diem Le, and Tran Nhat Phong Dao. "Ngu-Vi-Tieu-Khat decoction, a Vietnamese traditional medicine, possesses hypoglycemic and hypolipidemic effects on streptozotocin-induced type-2 diabetic rat model." Pharmacia 70, no. (4) (2023): 943–50. https://doi.org/10.3897/pharmacia.70.e108879.

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This study aims to assess the hypoglycemic effects of Ngu-Vi-Tieu-Khat (NVTK) decoction, a traditional Vietnamese medicine, in a rat model of type-2 diabetes. The NVTK decoction was prepared using the maceration method and tested for its hypoglycemic effects by measuring blood glucose levels, insulin resistance indicators, and pancreatic mass. The results showed that NVTK decoction improved diabetes symptoms, increased insulin levels, reduced insulin resistance, restored pancreatic mass, and decreased total cholesterol (TC), triglycerides (TG) and low-density lipoprotein cholesterol (LDL-C) while increasing high-density lipoprotein cholesterol (HDL-C). The hypoglycemic effects of NVTK were comparable to those of gliclazide at a dose of 10 mg/kg. In conclusion, NVTK decoction possesses hypoglycemic properties and could be explored as a potential traditional medicine for treating type-2 diabetes in humans.

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Kurian, Gino A. "Hypoglycemic effect of poly-herbal combination in streptozotocin-induced diabetic rats." Bangladesh Journal of Pharmacology 11, no. 2 (2016): 364. http://dx.doi.org/10.3329/bjp.v11i2.24855.

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The present study evaluates the combinatorial effect of a poly-herbal combination with multiple therapeutic effects as a hypoglycemic and hypolipidemic agent. Herbal combination of Salacia oblonga, Tinospora cordifolia, Emblica officinalis, Curcuma longa and Gymnema sylvestre was prepared and administered to streptozotocin (55 mg/kg, i.p.)-induced diabetic rats, at a dose of 100 mg/kg, for four weeks. The poly-herbal combination significantly elevated the plasma insulin (90%) and reduced serum glucose (42%), cholesterol (49%), triglycerides (43%), LDL cholesterol (62.5%) and plasma apo B/apo A in the diabetic rats. The liver lipogenic enzymes like HMG CoA reductase and glucose-6-phosphatase significantly declined (p&lt;0.05) in their activity while glucose-6-phosphate dehydrogenase and malic enzymes showed higher activity compared to the diabetic control. The results suggest a significant hypoglycemic and hypolipidemic property for the poly-herbal combination.

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Yin, Peipei, Shan Zhao, Siyu Chen, et al. "Hypoglycemic and Hypolipidemic Effects of Polyphenols from Burs of Castanea mollissima Blume." Molecules 16, no. 11 (2011): 9764–74. http://dx.doi.org/10.3390/molecules16119764.

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Santos, Enaide Soares, Geraldo Lucas Abrantes Coelho, Yan Kauê Saraiva Fontes Loula, et al. "Hypoglycemic, Hypolipidemic, and Anti-Inflammatory Effects of Beta-Pinene in Diabetic Rats." Evidence-Based Complementary and Alternative Medicine 2022 (May 17, 2022): 1–8. http://dx.doi.org/10.1155/2022/8173307.

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Background. Diabetes is a metabolic disease linked to multiple comorbidities, such as low-grade inflammation. β-pinene, a monoterpene commonly found in aromatic plants, is endowed with anti-inflammatory effect and this fact lead us to investigate the possible hypoglycemic, hypolipidemic and anti-inflammatory effects of the monoterpene in the alloxan-induced diabetes experimental model. Methods. Male Wistar rats (200–250 g) were treated orally with β-pinene (25, 50, 100, and 200 mg/kg) or glibenclamide (5 mg/kg), for seven consecutive days. Diabetes was induced by alloxan (40 mg/kg) through the penile vein. On the seventh day of treatment, blood samples were collected for biochemical analysis. The anti-inflammatory effect of β-pinene was evaluated using the carrageenan-induced paw edema model, followed by the carrageenan-induced peritonitis. Results. The treatment with β-pinene decreased plasma glucose, triglyceride, VLDL, LDL, and HDL levels, when compared to those of the control group. In addition, the association β-pinene 10 mg/kg + glibenclamide 2 mg/kg significantly decreased blood glucose, total cholesterol, and triglyceride level. Finally, oral treatment with β-pinene reduced carrageenan-induced paw edema and leukocyte migration in the peritoneum. Taken together, our results indicate that β-pinene shows hypoglycemic and hypolipemic effects, which may involve some common mechanisms of glibenclamide. Besides, the monoterpene presented an anti-inflammatory action in diabetic rats that needs further investigation in order to clarify such effect and its correlation with the alterations observed in plasma parameters of β-pinene-treated diabetic rats.

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Ashiq, Aisha, Saleem Jan, Yar Muhammad Khan, et al. "Hypoglycemic and hypolipidemic effects of Oligomeris linifolia in Alloxan-induced diabetic mice1." Current Trends in Biotechnology and Pharmacy 17, no. 2 (2023): 901–6. http://dx.doi.org/10.5530/ctbp.2023.2.27.

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Xie, Yun-Dong, Ji-Ping Liu, Wei Wang, et al. "3,4-Dihydroxyphenethyl nitrate with nitric oxide releasing, antioxidant, hypoglycemic and hypolipidemic effects." Bioorganic & Medicinal Chemistry Letters 30, no. 15 (2020): 127277. http://dx.doi.org/10.1016/j.bmcl.2020.127277.

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Islam, Dipa, Amdadul Huque, Sheuly, et al. "Hypoglycemic and hypolipidemic effects of Nelumbo nucifera flower in Long-Evans rats." Journal of Herbmed Pharmacology 7, no. 3 (2018): 148–54. http://dx.doi.org/10.15171/jhp.2018.25.

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Aissaoui, Abderrahmane, Soumia Zizi, Zafar H. Israili, and Badiâa Lyoussi. "Hypoglycemic and hypolipidemic effects of Coriandrum sativum L. in Meriones shawi rats." Journal of Ethnopharmacology 137, no. 1 (2011): 652–61. http://dx.doi.org/10.1016/j.jep.2011.06.019.

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Bermudes-Contreras, Juan David, Marcela Verónica Gutiérrez-Velázquez, Eli Amanda Delgado-Alvarado, René Torres-Ricario, and Jorge Cornejo-Garrido. "Hypoglycemic and Hypolipidemic Effects of Triterpenoid Standardized Extract of Agave durangensis Gentry." Plants 14, no. 6 (2025): 894. https://doi.org/10.3390/plants14060894.

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Diabetes mellitus is a chronic, degenerative, and multifactorial disease characterized by hyperglycemia, and at least 537 million people suffered from diabetes in 2021. Agave durangensis Gentry, a species of agave native to the state of Durango, reports phenolic compounds, flavonols, flavonoids, and saponins and could be an alternative for the treatment of diabetes. The aim of this work was to identify the compounds in the leaves of Agave durangensis Gentry and their potential activity in diabetes. The leaf extract of Agave durangensis Gentry (EAD) was characterized by ultra-performance liquid chromatography–mass spectrometry (UPLC-MS), and different families of bioactive compounds were quantified by analytical methods. Probable pharmacological targets were identified in silico, and the inhibition of dipeptidyl peptidase-4 (DPP4) was validated in vitro. A model of hyperglycemia was established with streptozotocin in male Wistar rats, and we administered EAD intragastrically at a dose of 300 mg/kg, as well as combinations of the extract with metformin and sitagliptin over 30 days. Biochemical and histological parameters were analyzed. We identified thirty-six major compounds, where triterpenes represented 30% of the extract. Molecular docking showed that the extract could interact with α-glucosidases and DPP4 since a large number of compounds in the extract have a Δ G lower than that reported for the controls, and DPP4 inhibition was confirmed by in vitro assays. In vivo assays demonstrated that the administration of the extract was able to significantly decrease glucose levels by 56.75% and glycosylated hemoglobin by 52.28%, which is higher than that reported for sitagliptin with a decrease of 35.22%. In addition, the extract decreased triglycerides by 59.28% and very-low-density lipoprotein (VLDL) cholesterol by 60.27%, and when administered in combination with metformin, it decreased them more than when metformin was administered alone. For all the above reasons, Agave durangensis Gentry extract could be used for the development of phytomedicine for the treatment of diabetes.

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Liu, Lina, Yihui Chen, Bei Chen, et al. "Advances in Research on Marine-Derived Lipid-Lowering Active Substances and Their Molecular Mechanisms." Nutrients 15, no. 24 (2023): 5118. http://dx.doi.org/10.3390/nu15245118.

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Hyperlipidemia (HLP) is a metabolic disorder caused by abnormal lipid metabolism. Recently, the prevalence of HLP caused by poor dietary habits in the population has been increasing year by year. In addition, lipid-lowering drugs currently in clinical use have shown significant improvement in blood lipid levels, but are accompanied by certain side effects. However, bioactive marine substances have been shown to possess a variety of physiological activities such as hypoglycemic, antioxidant, antithrombotic and effects on blood pressure. Therefore, the hypolipidemic efficacy of marine bioactive substances with complex and diverse structures has also attracted attention. This paper focuses on the therapeutic role of marine-derived polysaccharides, unsaturated fatty acids, and bioactive peptides in HLP, and briefly discusses the main mechanisms by which these substances exert their hypolipidemic activity in vivo.

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Nduka, A. G., A. O. Oluwatoyin, A. O. Temitope, and O. Odutola. "Hypoglycemic and hypolipidemic effects of Corchorus olitorius leaves as a food supplement on rats with alloxan-induced diabet." Ukrainian Biochemical Journal 92, no. 4 (2020): 63–69. http://dx.doi.org/10.15407/ubj92.04.063.

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Tahir, Farah Naz, Hania Ali, and Iqra Taqi. "HYPOLIPIDEMIC AND HYPOGLYCEMIC ACTIVITY OF MEDICINAL PLANTS IN STZ (STREPTOZOTOCIN) INDUCED HYPERLIPIDEMIC RATS AND THEIR ROLE IN HEALTH AND DISEASE." Gomal Journal of Medical Sciences 20, no. 1 (2022): 45–50. http://dx.doi.org/10.46903/gjms/20.01.1078.

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In the past few years, medical plants research focused on a lot by scientists all over the world. Many evidence has been studied to show the potential effects of medicinal plants in the medical field. This is due to the presence of many metabolites in plants that includes flavonoids, tannins, terpenoids, and many hypolipidemic and hypoglycemic agents. This study aims to evaluate various medicinal plants for anti-diabetic and hypolipidemic activity in rats. Diabetes mellitus is one of the most common non communicable diseases present globally and it’s most lethal complication which developed is dyslipidemia which ultimately leads to cardiovascular events which are hard to control and it’s not possible to revert back its effects. Since ancient times plants have been the source of medicine. Many kinds of literature mentioned the use of plants in the treatment of various diseases. This review covers the anti-diabetic and antihyperlipidemic effects of medicinal plants. Investigation of phytochemicals present in medicinal plants and their biological activities are reported. The hypolipidemic activity which is present in most medicinal plants is strongly associated with new drug development which will be used for high lipid profiles and cardiovascular disease.

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Ogechukwu, Celestina Iloka, Christiana Maduka Chinecherem, Ozoemena Nweke Chidimma, and Nkiru Sampson Rebecca. "Phytochemical composition, acute toxicity, hypoglycemic and hypolipidemic effects of ethanol extract of Allium sativum (garlic) bulb in male Wistar rats." World Journal of Advanced Research and Reviews 20, no. 2 (2023): 144–56. https://doi.org/10.5281/zenodo.12569186.

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Allium sativum (garlic) has been used in traditional medicine in Nigeria in the treatment of various ailments such as cold, cough, and microbial infections; and there have been various claims about its pharmacological activities including anti-inflammatory, antimicrobial, hypoglycemic, hypolipidemic, antioxidant, antidiabetic, and anticancer properties. However, there are insufficient data to back up these claims. It is against this backdrop, this study evaluated the phytochemical composition, acute toxicity, hypoglycaemic and hypolipidemic potentials of ethanol extract of A. sativum bulb in male Wistar rats in order to validate its therapeutic use as hypoglycaemic and hypolipidemic agent. Twenty adult male Wistar rats were randomly divided into four groups of five rats each where group 1 (control) received normal saline while group 2-4 received the extract at the doses of 200, 400, and 1000mg/kg b.w respectively for fourteen days. T-test and one-way ANOVA were used to test for significant (p<0.05) differences among the groups. Qualitative and quantitative phytochemical screening of the extract indicated the presence of flavonoids (17.59±0.01), saponins (13.55±0.01), alkaloids (2.06±0.06), tannins (0.04±0.00), phenols (0.01±0.00), phlobatanin, phytosterols and terpenoids whereas steroids, anthraquinones and glycosides were not detected. The administration of the extract produced a significant (P<0.05) decrease in the blood glucose concentration in the treatment groups compared to the control group, whereas a significant (P<0.05) decrease was observed in the total cholesterol concentration of group 4 only relative to the control. Furthermore, there was a significant (P<0.05) increase in the HDL concentrations and a significant (P<0.05) decrease in the triglycerides and LDL concentrations respectively in all treatment groups compared to the control group. From these findings therefore, we conclude that A. sativum offers both hypoglycemic and hypolipidemic effects in male Wistar rats.

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Sharmin, R., M. R. I. Khan, Most A. Akhtar, et al. "Hypoglycemic and Hypolipidemic Effects of Cucumber, White Pumpkin and Ridge Gourd in Alloxan Induced Diabetic Rats." Journal of Scientific Research 5, no. 1 (2012): 161–70. http://dx.doi.org/10.3329/jsr.v5i1.10252.

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Ethanolic extracts of some fruits of Cucurbitaceae family such as Cucumis sativus (cucumber), Lagenaria siceraria (white pumpkin), Luffa acutangula (ridge gourd), Benincasa hispida (ash gourd), Citrullus lanatus (sweet melon) and Cucarbita maxima (pumpkin) have been studied for their hypoglycemic effects on alloxan induced diabetic rats (AIDRs). Screening results suggested that among the tested fruits the hypoglycemic potency follows: cucumber > white pumpkin > ridge gourd. These three fruit-extracts were further investigated for their hypoglycemic, hypolipidemic and glycogenesis effects. Cucumber, white pumpkin and ridge gourd extracts reduced blood glucose level by 67, 65 and 51%, respectively at 12 hours after single intraperitoneal injection; while reduced the low density lipoprotein (LDL) level to 13, 28 and 86%, respectively in AIDRs. The maximum reduction 87% was observed by cucumber extract. Cucumber, white pumpkin and ridge gourd extracts reduced total cholesterol level to 29, 15 and 38%, respectively comparing with the diabetic control group. Here the maximum reduction of 85% was observed by white pumpkin extract. Cucumber, white pumpkin and ridge gourd also reduced triglyceride levels to 72, 68 and 80%, respectively. Maximum reduction of 32% was observed by white pumpkin. Significant improvement of glycogenesis was also observed by ridge gourd extracts in AIDRs.© 2013 JSR Publications. ISSN: 2070-0237 (Print); 2070-0245 (Online). All rights reserved.doi: http://dx.doi.org/10.3329/jsr.v5i1.10252 J. Sci. Res. 5 (1), 161-170 (2013)

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Rahman, Shahid, Gul Jan, Farzana Gul Jan, and Hafeez Ur Rahim. "Phytochemical Investigation and Therapeutical Potential of Cotinus coggygria Scop. in Alloxan-Induced Diabetic Mice." Oxidative Medicine and Cellular Longevity 2022 (December 31, 2022): 1–14. http://dx.doi.org/10.1155/2022/8802178.

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Plants are a significant source for the development of new phytomedicines due to their great clinical benefits, efficiency, cost-effectiveness, fewer side effects, and more affordable therapies. Numerous plants used in traditional treatments, such as Cotinus coggygria Scop., have been effective in the treatment of diabetes mellitus (DM). Therefore, the study is aimed at assessing the phytochemical, antioxidant, and antidiabetic properties of C. coggygria. The hypoglycemic and hypolipidemic activity was evaluated in Swiss male Albino mice by administering an oral dose of 150-250 mg/kg of C. coggygria extracts in alloxan-induced diabetic mice for 15 days. The antioxidant activity and phytochemical composition of the extracts were assessed by using α, α diphenyl-β-picrylhydrazyl (DPPH) and hydrogen peroxide scavenging assays and through standard chemical procedures. The effects of extracts on blood glucose, body weight, lipid profile, and biochemical parameters like total cholesterol (TC), triglyceride (TG), low-density lipids (LDL), high-density lipids (HDL), plasma insulin, liver glycogen, aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), urea, and creatinine were determined according to standard procedures. The activities of antioxidant enzymes such as superoxide-dismutase (SOD), peroxidase (POD), and catalase (CAT) were also analyzed spectrophotometrically. The hypoglycemic and hypolipidemic effects with chloroform extracts of 250 mg/kg were found significant in the treatment of diabetes in alloxanised mice compared to the diabetic group. The haematological parameters such as TC, TG, HDL, LDL, creatinine, urea, AST, ALT, and ALP were significantly improved ( p < 0.01 ) by the chloroform extract of 250 mg/kg compared to the diabetic group. Treatment for 15 days showed significant elevation ( p < 0.01 ) of antioxidant enzymes. Fourier-transform infrared spectroscopic (FTIR) and gas chromatography–mass spectrometry (GC-MS), column chromatography (CC), and nuclear magnetic resonance (NMR) analyses tentatively identified different phytoconstitutents and metabolites in C. coggygria leaves, which have been reported to possess antihyperglycemic properties. In conclusion, the chloroform extract of 250 mg/kg of C. coggygria possesses significant hypoglycemic and hypolipidemic potential which may prove the claimed use of the plant in amelioration of diabetes and associated complications in folkloric medicine. Additional studies are required for the purification, characterization, and structural elucidation of bioactive compounds.

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J, Goje L., Maisamari C.A, F.U Maigari, P.E Ghamba, A.D.T. Goji, and P.P Mshelia. "The Hypoglycemic and Hypolipidemic Effects of the Aqueous Extract of Vernonia Amygdalina Leaves on Alloxan Induced Diabetic Albino Rats." International Journal of Sciences Volume 3, no. 2014-09 (2014): 5–11. https://doi.org/10.5281/zenodo.3348777.

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The study was conducted to determine the hypoglycemic and hypolipidemic effects of the aqueous extract of vernonia amygdalina leaves extract. Healthy albino rats weighing between 200g and 230g were used. The rats were divided in to four different groups each containing five albino rats respectively. Three of the groups (b, c and d) were induced with diabetes by the administration of alloxan monohydrate at a concentration of 150mg/kg through intraperitoneal injection. The fasting blood glucose of the rats and their weights were measured before and after the induction of diabetes using glucose metre. After the induction of diabetes the rats were treated using the aqueous extract of vernonia amygdalina leaves at different concentrations (100, 150 and 200mg/kg) respectively according to group daily, where as, the other group (a) was not given any treatment and this served as the normal control, providing a baseline data. The experiment lasted for two weeks after which the animals were sacrificed by surgical dislocation of the neck following 16 hours fasting. The serum was obtained and used for the analysis of lipid profile and fasting blood glucose. All the treatment groups showed a significant decrease in fasting blood glucose level (p<0.05) when compared with their respective alloxan induced diabetic values. Also, all the treatment groups did not have significantly different values from the normal control (p>0.05) in the case of the parameters of lipid profile. Therefore, it was concluded that the aqueous extract of vernonia amygdalina leaves had both hypoglycemic and hypolipidemic effects on alloxan induced diabetes.Read Complete Article at ijSciences: V3201408540

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Ahamed, Ridoy, Afifa Parvin Shanta, Israt Jahan Bulbul, Md Mahbubur Rahman Tanim, Md Ruhul Kuddus, and Mohammad A. Rashid. "Hypoglycemic and Hypolipidemic Activities of Bile of Bangladeshi Labeo rohita on Streptozotocin (STZ) - Induced Diabetic Rats." Bangladesh Pharmaceutical Journal 25, no. 1 (2022): 32–37. http://dx.doi.org/10.3329/bpj.v25i1.57838.

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Diabetes mellitus (DM) is one of the most commonly diagnosed condition all over the world. Fish is a typical delicacy and one of the most nutritious foods available. Fresh fish bile, according to various indigenous healthcare professionals in Bangladesh, has anti-diabetic effects and its importance in the treatment or management of diabetes and cardiovascular illnesses has also been documented in few recent studies. The goal of this work was to test the hypoglycemic potential of Labeo rohita bile content in order to objectively validate this folklore claim. In this study, in-vivo investigation of the hypoglycemic and hypolipidemic activities of L. rohita bile was performed against a streptozotocininduced diabetic rat model. Rats were given bile extract at doses of 0.08 ml/kg body weight and 0.16 ml/kg body weight for one week. Here, metformin HCl (100 mg/kg body weight) was used as reference standard. Both the doses of bile extract exhibited significant hypoglycemic effect (p<0.05) compared to control as well as untreated diabetic control rats. Total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C) levels were also investigated from blood samples followed by 7 days of therapy. The results revealed that both doses of L. rohita bile bear a significant hypolipidemic effect. This study could be beneficial in diabetic and hyperlipidemia conditions. Bangladesh Pharmaceutical Journal 25(1): 32-37, 2022 (January)

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Rivera, Antonio, Elvia Becerra-Martinez, Yesenia Pacheco-Hernández, Gerardo Landeta-Cortés, and Nemesio Villa-Ruano. "Synergistic hypolipidemic and hypoglycemic effects of mixtures of Lactobacillus nagelii/betanin in a mouse model." Tropical Journal of Pharmaceutical Research 19, no. 6 (2020): 1269–76. http://dx.doi.org/10.4314/tjpr.v19i6.23.

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Purpose: To determine the nutraceutical effect of mixtures containing Lactobacillus nagelii/betanin on the carbohydrate and lipid metabolism of mice.Methods: Lactobacillus nagelii and betanin were isolated from the raw materials. These components were subsequently assessed for their anti-hyperglycemic and hypolipidemic activities, and administered individually or combined in normoglycemic and diabetic mice. These animals were subjected to a standard OGTT and given an atherogenic diet.Results: The combination of L. nagelii (2.0 × 109 CFU/mL) and betanin (30 mg/kg body weight) exerted a significant (p < 0.01) and prolonged reduction of postprandial blood glucose (30 - 120 min). Interestingly, a mixture of L. nagelii (1 ×107 CFU/mouse/day) with betanin (10 mg/kg body weight) administered for 30 days, produced favourable effects (p < 0.01) in the lipid profile of mice previously treated with an atherogenic diet. These mixtures significantly ameliorated (p < 0.01) hypoinsulinemia, hyperleptinemia and increased the levels of adiponectin.Conclusion: The simultaneous administration of L. nagelii and betanin in mice produced a beneficial change in blood glucose and lipids in mice, indicating a synergistic nutraceutical effect. However, there is a need to develop this therapy further for potential application in humans Keywords: Lactobacillus nagelii, Betanin, Anti-hyperglycemic, Hypolipidemic

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El-Noweihi, Amira, Nagla Elmelegy, Sally Bakar, and Shimaa El-Nasser. "HYPOGLYCEMIC AND HYPOLIPIDEMIC EFFECTS OF GINGER IMPROVE KIDNEY FUNCTION IN OBESE MALE RATS." Bulletin of Pharmaceutical Sciences. Assiut 42, no. 1 (2019): 19–29. http://dx.doi.org/10.21608/bfsa.2019.62260.

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Nweze, Chibuzo, Tayyibah Lay, Abdullahi Muhammad, and Abraham Ubhenin. "Hypoglycemic, Hepatoprotective and Hypolipidemic Effects of Pleurotus ostreatus in Alloxan-Induced Hyperglycemic Rats." Tropical Journal of Natural Product Research 1, no. 4 (2017): 163–67. http://dx.doi.org/10.26538/tjnpr/v1i4.5.

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Laaboudi, Wafa, Jamal Ghanam, Oumaima Ghoumari, Fatiha Sounni, Mohammed Merzouki, and Mohamed Benlemlih. "HYPOGLYCEMIC AND HYPOLIPIDEMIC EFFECTS OF PHENOLIC OLIVE TREE EXTRACT IN STREPTOZOTOCIN DIABETIC RATS." International Journal of Pharmacy and Pharmaceutical Sciences 8, no. 12 (2016): 287. http://dx.doi.org/10.22159/ijpps.2016v8i12.14077.

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Objective: The aim of the present study was to determine the effects of an olive tree extract with high polyphenols content on blood glucose level and other related parameters in streptozotocin-induced diabetic rats.Methods: Diabetes was induced in rats by intraperitoneal injection of streptozotocin (55 mg/kg bw). 72h after injection, rats with fasting blood glucose higher than 2 g/l were used for the experiments. Olive tree extract was administered for 28 d and blood glucose level was measured every 4 d. Total cholesterol, triglycerides, HDL-cholesterol, creatinine, urea, total protein, uric acid, aspartate aminotransferase and alanine aminotransferase levels, were determined at the end of the experiment.Results: The oral administration of olive tree extract contributes to blood glucose level decreasing in diabetic rats group, which was significantly lower at 4th week compared to the diabetic control rats. Moreover, supplementation by olive tree extract decreased significantly (p&lt;0.05) the values of total cholesterol, triglycerides, HDL-cholesterol, creatinine, urea, total protein, uric acid, aspartate aminotransferase and alanine aminotransferase resulting from damage caused by streptozotocin treatment. Beside this, significant reduce (p&lt;0.05) in heart disease risk ratio was observed for treated group (4.1±0.14) compared to untreated group (7.64±0.36), which was quite similar to normal rats (4.50±0.36). Studied olive tree extract effects were similar to those of glibenclamide, a well-known antidiabetic drug.Conclusion: Results herein obtained reveal the hypoglycemic effect of this olive tree extract, suggesting his potential use as a natural antidiabetic agent.

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Hwang, Ji-Yeon, Jian Zhang, Min-Jung Kang, et al. "Hypoglycemic and hypolipidemic effects of Saururus chinensis Baill in streptozotocin-induced diabetic rats." Nutrition Research and Practice 1, no. 2 (2007): 100. http://dx.doi.org/10.4162/nrp.2007.1.2.100.

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Lee, Soo Jung, Gui Fang Zhang, and Nak Ju Sung. "Hypolipidemic and hypoglycemic effects ofOrostachys japonicusA. Berger extracts in streptozotocin-induced diabetic rats." Nutrition Research and Practice 5, no. 4 (2011): 301. http://dx.doi.org/10.4162/nrp.2011.5.4.301.

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Seo, Dongyeon, Naeun Kim, Ahyeong Jeon, et al. "Hypoglycemic and hypolipidemic effects of unsaponifiable matter from okra seed in diabetic rats." Nutrition Research and Practice 18, no. 3 (2024): 345. http://dx.doi.org/10.4162/nrp.2024.18.3.345.

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Journal articles on the topic 'Hypoglycemic and hypolipidemic effects'

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