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Dissertations / Theses on the topic 'Hypoglycemic effect'

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Published: 2 June 2025

Last updated: 19 July 2025

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1

Yoshida, Makiko. "Plant sterols and glucomannan as hypocholesterolemic and hypoglycemic agents in subjects with and without type 2 diabetes." Thesis, McGill University, 2003. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=80900.

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The objective of this research was to examine the effects of plant sterols and glucomannan on lipid profiles, plasma plant sterol levels and glycemic control in mildly hypercholesterolemic subjects. Thirteen type 2 diabetic and sixteen non-diabetic individuals participated in a randomized crossover trial consisting of 4 phases, of 21 days each. During the study period, subjects were supplemented with plant sterols and/or glucomannan. Overall reductions of total cholesterol and low-density lipoprotein (LDL) cholesterol concentrations were greater after consumption of plant sterols and gl

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2

Hoa, Nguyen Khanh. "Assessment of anti-diabetic effect of Vietnamese herbal drugs /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-585-2/.

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3

Mourad, Carine J. "Effect of glucose control on satiation, gut hormones and metabolic response to a meal in type 2 diabetes mellitus." Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=112543.

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Type 2 diabetes mellitus (T2DM) is often characterized with hyperglycemia, delayed gastric emptying time and a blunted response of gut hormones during feeding that may modulate hunger and satiety. We hypothesized that poor diabetes control is associated with greater hunger suppression, satiation and satiety than good control. We studied 9 T2DM men, after an overnight fast and in response to a 689 kcal mixed meal, twice with or without oral antihyperglycemic agents in a crossover design. Untreated, subjects had higher fasting and postprandial glucose, showed prolonged gastric emptying time and

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4

Lau, Vivian Wai Yan 1977. "Effects of plant sterols on plasma lipid profiles, glycemic control of hypercholesterolemic individuals with and without type 2 diabetes." Thesis, McGill University, 2003. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=80312.

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Plant sterols (PS) are effective in reducing plasma lipid concentrations, however, few studies have examined their cholesterol lowering effects in type 2 diabetics. The objective was to assess whether PS consumption alters blood lipid profile in hypercholesterolemic subjects with and without type 2 diabetes. Fifteen control subjects (age = 55.1 +/- 8.5 yr and BMI = 26.9 +/- 3.0kg/m2) and fourteen diabetic subjects (age = 54.5 +/- 6.7 yr and BMI = 30.2 +/- 3.0kg/m2) participated in a double-blinded, randomized, crossover, placebo-controlled feeding trial. The Western diet included either

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5

Guerra, Perrin Yannis Sergio. "Inpatient basal bolus regimens| Insulin Glargine/Lispro versus Insulin NPH/Regular. Retrospective comparison of hypoglycemic rates and glucose control, and the differential effect of non-clinical temporal factors on them." Thesis, Rush University, 2013. http://pqdtopen.proquest.com/#viewpdf?dispub=1523752.

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<p> Objective: Inpatient protocols for glycemic control</p><p> Research Design and Methods: This retrospective observational study analyzed the adult admissions to a Teaching Hospital from October 2010 to February 2013. The association between the protocol using insulin Glargine/Lispro vs NPH/regular and rates of hypoglycemia (glucose ≤ 70 mg/dl), severe hypoglycemia (≤ 550 mg/dl), severe hyperglycemia (≥ 300 mg/dl), and average glucose per patient-day were evaluated. The effect on these outcomes of being hospitalized on the week/weekend and the personnel shift (7-3, 3-11, 11-7) wer

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6

Schutz, Peter W. "Neuroprotective effects of ketone bodies during hypoglycemia." Thesis, University of British Columbia, 2011. http://hdl.handle.net/2429/34014.

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The ketone body D-3-hydroxybutyrate (3OHB) is an alternative energy substrate for the brain during hypoglycemia. The capacity and limitations of 3OHB to compensate for cerebral glucose depletion in developing brain is insufficiently understood. We studied the effect of 3OHB treatment in a newly developed infant rat model of insulin induced, sustained, and EEG-controlled hypoglycemia. Continuous treatment with 3OHB during hypoglycemia resulted in increased 3OHB plasma levels in hypoglycemic animals and delayed the onset of clinical coma and of EEG burst-suppression (burst-suppression coma). 3O

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7

Boyer, Didier. "Les hypoglycémies induites par le disopyramide : à propos d'un cas." Bordeaux 2, 1988. http://www.theses.fr/1988BOR25339.

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8

ZERBIB, PHILIPPE. "Hypoglycemie induite par les antiarythmiques : cas cliniques et revue de la litterature." Nice, 1989. http://www.theses.fr/1989NICE6576.

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9

Schenk, Sarah E. "Acute and recurrent hypoglycemia modulates brain glycogen metabolism in the mouse." Muncie, Ind. : Ball State University, 2009. http://cardinalscholar.bsu.edu/618.

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10

Shum, Kar Man Kathy. "Effects of antecedent hypoglycemia, antecedent hyperinsulinemia, and antecedent corticosterone on subsequent counterregulation in normal rats." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0021/MQ54188.pdf.

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11

McMahon, Sarah Kate. "Glucose requirements to maintain euglycaemia during and following moderate intensity afternoon exercise in adolescents with type 1 diabetes mellitus : an insight to the risk of exercise-associated hypoglycaemia." University of Western Australia. School of Paediatrics and Child Health, 2009. http://theses.library.uwa.edu.au/adt-WU2010.0084.

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Exercise has a wide range of benefits for patients with type 1 diabetes, including improvements in body composition, cardiovascular risk profile and glycaemic control. Unfortunately, exercise also increases the risk of hypoglycaemia in children with type 1 diabetes, both at the time of exercise and for many hours afterwards. The availability of clear, evidence-based guidelines regarding appropriate adjustments in carbohydrate intake or insulin doses may help to prevent this exercise associated hypoglycaemia. However, current guidelines regarding exercise in children with type 1 diabetes rely h

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12

Roffey, Ben. "The effects of Momordica charantia and cinnamon extracts on glucose uptake and adiponectin secretion in 3T3-L1 adipose cells /." Thesis, McGill University, 2006. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=98782.

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To examine the effects of Momordica charantia (MC) and cinnamon on glucose uptake and adiponectin secretion (AS) fat cells, 3T3-L1 adipocytes were treated with a water extract of cinnamon (CE) and three concentrations of MC water and ethanol extracts. The treatment combination of 0.2 mg/ml MC water extract and 0.5 nM insulin was associated with an increased glucose uptake into the cells (61%) and increased AS from the cells (75%). Without insulin, 0.2 mg/ml of CE increased glucose uptake (100%) and completely inhibited AS from the cells. Sub-optimal concentrations of insulin did not further en

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13

Chaverneff, Florence. "CK2 Contributes to the Synergistic Effects of BMP7 and BDNF on Smad 1/5/8 Phosphorylation in Septal Neurons." Scholarly Repository, 2008. http://scholarlyrepository.miami.edu/oa_dissertations/352.

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The combination of bone morphogenetic protein 7 (BMP7) and neurotrophins (e.g. brain-derived neurotrophic factor, BDNF) protects septal neurons during hypoglycemic stress. I investigated the signaling mechanisms underlying this synergistic protection. BMP7 (5 nM) increased phosphorylation and nuclear translocation of BMP-responsive Smads 1/5/8 within 30 min in cultures of rat embryonic septal neurons. BDNF (100 ng/ml) enhanced the BMP7-induced increase in phospho-Smad levels in both nucleus and cytoplasm; this effect was more pronounced after a hypoglycemic stress. BDNF increased both Akt and

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14

Vogel, Etresia. "The effect of the glycemic index on endurance performance." Pretoria : [S.n.], 2007. http://upetd.up.ac.za/thesis/available/etd-01032007-130823/.

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15

Liu, Xu-Jing. "Effects of maternal dietary carbohydrate on phosphoenolpyruvate carboxykinase development in the fetus and neonate." Thesis, McGill University, 1995. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=23282.

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The effect of maternal dietary glucose on perinatal phosphoenolpyruvate carboxykinase (PEPCK) gene expression was investigated in this study. Pregnant rats were fed isoclaoric diets containing graded levels of glucose (0%, 12%, 24% and 60%) from gestation day 2 to lactation day 15. The developmental profiles of PEPCK gene expression in fetal and neonatal liver and kidney were analyzed by northern blot. In the liver, feeding glucose free and glucose restriction (12% and 24%) diets precociously induced PEPCK gene expression at day 21 of gestation. In the kidney, PEPCK mRNA (2.8 kb) was detected

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16

Louey, Samantha 1977. "The effects of intrauterine growth restriction on postnatal growth, arterial pressure and the vasculature." Monash University, Dept. of Physiology, 2003. http://arrow.monash.edu.au/hdl/1959.1/7939.

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17

Metcalf, Kristen Marie. "Effects of moderate to vigorous-intensity physical activity on nocturnal and next day hypoglycemia in adolescents with Type 1 Diabetes." Thesis, University of Iowa, 2013. https://ir.uiowa.edu/etd/2580.

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Physical activity (PA) provides many benefits to adolescents with Type 1 Diabetes (T1D); however, adolescents with T1D tend to have lower fitness and PA levels. One reason adolescents with T1D engage in less PA is due to a fear of hypoglycemia. Most studies examining PA in relation to glycemic control measure PA through self-report, thus introducing bias. The purpose of this study was to objectively monitor PA and glucose in adolescents with T1D to examine the temporal associations between moderate and vigorous intensity p

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18

Al-Salami, Hani, and n/a. "The combination of probiotics, 12-monoketocholic acid (bile acid) and gliclazide in a rat model of type 1 diabetes : hypoglycemic effects, pharmacokinetics and transport studies." University of Otago. School of Pharmacy, 2009. http://adt.otago.ac.nz./public/adt-NZDU20090903.150030.

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Type 1 diabetes (T1D) is a metabolic disorder characterized by destruction of the pancreatic beta-islet cells leading to complete loss of insulin production. Gliclazide is used in Type 2 diabetes (T2D) to stimulate insulin production but it also has beneficial extrapancreatic effects which make it potentially useful in T1D. In fact, some T2D patients continue to use gliclazide even after their diabetes progresses to T1D since it provides better glycemic control than insulin alone. About 30% of a gliclazide dose undergoes enterohepatic recirculation which may contribute to the observed high int

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19

Wenell, Lydia. "The effect on HbA1c in patients with type 2diabetes who start with FreeStyle Libre– a retrospective study of medical records in Region Örebro County, 2019." Thesis, Örebro universitet, Institutionen för medicinska vetenskaper, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-81558.

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IntroductionFreeStyle Libre (FSL) has mostly been used by patients with type 1 diabetes. In 2019, newrecommendations were announced regarding prescriptions to patients with type 2 diabetes(T2D) who have insulin treatment (basal/bolus), HbA1c > 70 mmol/mol and/or repeatedhypoglycemic events despite great effort to adjust insulin doses.AimTo evaluate if HbA1c improves with FSL compared with self-monitoring of blood glucose. Thesecondary aim was to investigate if patients with recurrent hypoglycemic events experiencedless hypoglycemic events.MethodsThis study was designed as a retrospective sy

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20

Yardley, Jane E. "The Acute Effects of Aerobic and Resistance Exercise on Blood Glucose Levels in Type 1 Diabetes." Thèse, Université d'Ottawa / University of Ottawa, 2011. http://hdl.handle.net/10393/20031.

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Aerobic exercise interventions involving individuals with type 1 diabetes have had little positive effect on blood glucose control as reflected by hemoglobin A1c. The few existing interventions involving resistance exercise, either alone or combined with aerobic exercise, while small in sample size, have had better outcomes. The purpose of this research program was to examine the changes in blood glucose levels during activity and for 24 hours post-exercise (as measured by continuous glucose monitoring) when resistance exercise is performed, either on its own or combined with aerobic exercise,

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21

Boyer, Philippe. "Hypoglycémies dues aux sulfamides hypoglycémiants." Paris 5, 1991. http://www.theses.fr/1991PA05P038.

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22

Roy, Brenda Nicole. "The effects of a simulated menstrual cycle and insulin-induced hypoglycemia on corticotropin-releasing hormone, arginine vasopressin and proopiomelanocortin messenger ribonucleic acid levels in the hypothalamus of the nonhuman primate." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp02/NQ38329.pdf.

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23

Nordfeldt, Sam. "On Severe Hypoglycaemia in Children and Adolescents with Type 1 Diabetes." Doctoral thesis, Linköping : Univ, 2000. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-5018.

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24

Parent, Cassandra. "Excursions (hypo- et hyperglycémiques) et variabilité glycémique en réponse à différents types d'exercices aigus chez des personnes qui n'ont pas de diabète ou vivant avec le diabète de type 1." Electronic Thesis or Diss., Université de Lille (2022-....), 2023. http://www.theses.fr/2023ULILS064.

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Le diabète de type 1 (DT1) se caractérise par la destruction auto-immune des cellules ß des îlots de Langerhans du pancréas productrices d'insuline, entraînant un état d'hyperglycémie chronique. Malgré une prise en charge très fine de la maladie, s'appuyant sur l'insulinothérapie fonctionnelle, les personnes vivant avec le DT1 sont fréquemment sujettes à des épisodes hypoglycémiques et hyperglycémiques en raison de difficultés à adapter le traitement insulinique, notamment lors de l'activité physique. L'activité physique procure de nombreux bénéfices pour la santé que l'on ait ou non un diabèt

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25

Lin, Feng-jen, and 林峰任. "Investigating the Effective Compounds of the Hypoglycemic effect in Longan Flower Water Extract." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/94243200449077795211.

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碩士<br>中原大學<br>生物科技研究所<br>100<br>Diabetes is a popular metabolic diseases, the patients with hyperglycemia lead to ketoacidosis, spasm, coma or even death, and more likely to get some complications, such as cardiovascular disease and renal disease. Consequently, how to improve diabetes is an important issue for developed countries. In our previous study, we have show that ethyl acetate fraction of Longan flower water extract (LFEA) improved hyperglycemia, hypertriglyceridemia and insulin resistance in streptozotocin induced type 2 diabetic rats. Nevertheless, the molecular mechanism and effecti

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26

Found, Jeremy. "The effect of volitional endurance training on hypoglycemic counter-regulation in Male Sprague-Dawley rats /." 2008. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pqdiss&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&rft_dat=xri:pqdiss:MR51527.

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Thesis (M.Sc.)--York University, 2008. Graduate Programme in Kinesiology and Health Science.<br>Typescript. Includes bibliographical references (leaves 49-64). Also available on the Internet. MODE OF ACCESS via web browser by entering the following URL: http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pqdiss&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&rft_dat=xri:pqdiss:MR51527

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27

WEN-HSIN and 許文馨. "The hypoglycemic effect of leave essential oil of Cinnamomum osmophloeum Kaneh. on STZ-DM rats." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/66710745639221610156.

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碩士<br>中山醫學大學<br>營養學研究所<br>98<br>The aim of this study was to investigate the anti-diabetic effect of Leave essential oil of Cinnamomum osmophloeum Kaneh. Male Wistar rats were induced to be diabetes with STZ (65 mg / kg BW, iv). At three days after the induction of diabetes, rats received every other day for 8 times by gavage low, medium or high dose of leave essential oil of Cinnamomum osmophloeum Kaneh. , Cinnamaldehyde (40mg/kg Bw), glybenclamide（1.2 mg/kg Bw) or vehicle (corn oil, 2 ml/kg Bw). Control rats received corn oil only. ITT or OGTT was carried out at 10 or 17 days after the induc

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Tzeng, Chung-Yuh, and 曾崇育. "The study of hypoglycemic effect of electroacupuncture by reducing insulin resistance in chronic steroid induced insulin resistance rats and signaling pathways associated with hypoglycemic activity of ST 36 electroacupuncture." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/62714443948862441271.

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博士<br>國立清華大學<br>分子醫學研究所<br>104<br>This study is designed to evaluate the treatment effect of electroacupuncture (EA) in chronic steroid induced insulin resistant rat model. An alternative therapy is explored to reduce the chronic steroid induced insulin resistance.The aim of this study is to determine (1) if EA treatment can produce hypoglycemic effect and (2) inhibit the development of glucocorticoid-altered insulin sensitivity in chronic status and to (3) explore the mechanisms of EA by assaying plasma FFAs and proteins of insulin signal pathway. Intravenous glucose tolerance test (IVGTT) a

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29

Huang, Shih-yuan, and 黃仕元. "A study on the Hypoglycemic Effect Of Crude Extracts From Several Chinese Drug and Folk Herd." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/51249790418053326657.

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碩士<br>美和科技大學<br>健康與生技產業研究所<br>101<br>The main purpose of this study is to sutdy potential hypoglycemic effects from the extracts of several natural Chinese drugs and folk herbs. Specifically, our laboratory has carefully selected seven different Chinese herbal medicines, including ethyl acetate (EA) extract of leaf of Gonocaryum calleryanum (A), seed of Gonocaryum calleryanum (B), Zamia furfuracea Linn (C), Sapindus mukorossii Gaertner (G), Koelreuteria henryi Dummer (I), methanol extracts of Koelreuteria henryi Dummer, and seventy kinds of fermentation from Antrodia cinnamomea (NB-HDM1-70), t

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Chen, Nai-Qi, and 陳乃琦. "Studies of molecular mechanisms of NQ-1 on the hypoglycemic effect in vitro and in vivo." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/33095871920463522798.

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碩士<br>臺北醫學大學<br>醫學科學研究所<br>96<br>Peroxisome proliferator-activatived receptors (PPARs) are members of the nuclear hormone receptor superfamily of ligand-dependent transcription factors. PPARs play a central role in insulin sensitivity, lipid metabolism, glucose homeostasis, cell cycle progression, and inflammation. For the control blood glucose level of diabetes mellitus patient, searching PPAR activators from natural and synthetic chemicals, and discovering their associated functions is one of the most important works in the field. NQ-1 is a hydrophobic chemical and extracted from Chinese her

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Lau, Pey-Fen, and 劉珮芬. "The evaluation of hypoglycemic effect of exo-biopolymer from Agaricus blazei Murill combined with diabetic drugs." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/83685227462509417059.

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碩士<br>南台科技大學<br>生物科技系<br>97<br>Diabetes mellitus (DM) has become a major global disease, especially the complex complication which raises the seriousness of the diabetes. Agaricus blazei Murill is a common fungi treated for food and medicine. Its abundant polysaccharides to possess strong bioactivities which have remarkable function in improvement of immune system, enhancing anti-tumor, activity reducing blood-lipid, etc. The object of the study is to study the effect of hypoglycemic on the mice by treating with exo-biopolymer of Agaricus blazei Murill. In vivo, the exo-biopolymer of Agaric

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Chang, Che-Hao, and 張哲豪. "Antioxidant Activity of Lagenaria siceraria Fruit Extract and its Hypoglycemic Effect on STZ-induced Diabetes Mice." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/3585ky.

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碩士<br>國立虎尾科技大學<br>生物科技研究所<br>102<br>This study aims to investigate the ethanol extract of Lagenaria siceraria fruit (EELS) for Streptozotocin (STZ)-induced diabetic mice, blood glucose concentration. Experiment, BALB/c male mice were used as experimental animals by intraperitoneal injection of Nicotinamide (230 mg/kg) and STZ (65 mg/kg) as the induction dose, a type II diabetic mice. Experiments were carried out six weeks, the diabetic mice and normal mice were divided into five groups, respectively normal control group, diabetes control group, diabetes fed 100 mg/kg EELS, diabetes fed 500 mg/

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Wu, Ning-Jung, and 吳寧容. "Hypoglycemic effect of guava (Psidium guajava Linn.) leaf extracts in streptozotocin-nicotinamide induced type 2 diabetic rats." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/48242811810693100226.

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碩士<br>國立臺灣大學<br>食品科技研究所<br>95<br>Diabetes mellitus (DM) is one of the major diseases that human being eagerly wants to overcome. In 2006, DM was the fourth of top ten causes of death in Taiwan and more than 95% are type 2 DM. Guava (Psidium guajava Linn.) is one of the most important economic fruit in Taiwan. Leaves and fruit of guava are believed to have hypoglycemic effects which have been popularly employed in traditional DM treatment in Taiwan. However, there is insufficient scientific evidence for guava to cure DM, especially type 2 DM. In the present study, we injected low-dose streptozo

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CHEN, BAO-JYI, and 陳保吉. "Study of the Hypoglycemic Effect on Steroid Induced Insulin Resistant Rat by Electroacupuncture Combined with Acarbose Therapy." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/nm4j9w.

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碩士<br>大葉大學<br>藥用植物與保健學系<br>105<br>Background: Previous study found that electroacupuncture (EA) on Zusanli (ST36) with hypoglycemic effect, and related to β-endorphin. In the clinical treatment, Acarbose is less side effect in lowering plasma glucose. The aim of this study is to investigate the effects of 15 Hz EA on Zusanli(ST36) combined with acarbose to reduce plasma glucose, and to explore the possible mechanisms. In this study, using the normal Wistar rats and using steroid induced insulin resistant rat (SIIR) (Dexamethasone, 1 mg / kg, i.p., once a day for 5 days). Then the rats were div

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Chang, Chih-Shiang, and 張智翔. "Study on the hypoglycemic effect of the ethyl acetate extract of Curcubita moschata fruit in animal models." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/43652146121745893153.

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碩士<br>國立屏東科技大學<br>生物科技系所<br>104<br>The fruit of Cucurbita moschata has been confirmed to contain hypoglycemic components, and which can be further concentrated by partitioning between ethyl acetate (EA) and water to distribute them to the EA layer. The purpose of this study is to investigate the hypoglycaemic effect of the EA extract in diabetic animal models. To establish type 2 diabetic models, mice were fed with high-fat diet to induce insulin resistance, followed by injection of streptozotocin (stz) to destroy the pancreatic cell. The mice were then fed with the EA extract of pumpkin for

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Chen, Bo-Han, and 陳柏翰. "Study of microwave extraction crude triterpenoids from Poria cocos solid-state fermented products and its hypoglycemic effect." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/c4rnfr.

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碩士<br>國立宜蘭大學<br>食品科學系碩士班<br>102<br>Poria cocos is an edible and medicinal fungi, the main bioactive compounds are polysaccharides and triterpenoids. The pharmacological studies confirmed that it has several effects such as anti-inflammatory, antioxidant, immunomodulatory, anti-tumor, hypoglycemic, sedative, diuretic, antiemetic etc. The objectives of this study were (1) to explore the microwave power, extraction time of the crude polysaccharides and triterpenoids content in the Poria cocos solid-state fermented products, and to compare its extraction efficiency with hot water extraction and ul

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Fan, Wen-Hsuan, and 范文瑄. "Effect of hypoglycemic and antioxidant formula on chronic inflammation and thrombogenic risk factors in type 2 DM patients." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/45801395400884508505.

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碩士<br>靜宜大學<br>食品營養研究所<br>99<br>During the past 10 years, the prevalence of type 2 diabetes is increased dramatically in Taiwan. Hyperglycemia-induced oxidative damage plays an important role in the development of chronic complications in type 2 diabetic patients. Therefore, the purpose of this study was to investigate the effectiveness of market-sold hypoglycemic formula (HF) and antioxidant formula (AF) on chronic inflammation and thrombogenic risk in type 2 diabetic patients. Ninety type 2 DM patients were randomly assigned into six experimental groups in this double-blinded study. Treatment

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Huang, Po-Kai, and 黃柏凱. "Molecular docking of anti-dipeptidyl peptidase-4 natural compounds potentiated the hypoglycemic effect of glucagon like pepetide-1." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/84735667899502124320.

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碩士<br>國立東華大學<br>生命科學系<br>101<br>Herbs and natural supplements for diabetic therapy are wieldy used and generally have good efficacy. However the advances in promoting anti-diabetic agents are not satisfying. Dipeptidyl peptidase Ⅳ (DPP Ⅳ)/CD26, a cell surface glycoprotein, can degrade glucagon like pepetide-1 (GLP-1) by decreasing the blood glucose concentration, and is an upstream regulator of extracellular signal-regulated kinase (ERK). In the present study, DPP Ⅳ structure (PDB number: 2ONC) was chose as a template to do docking against potential natural compounds obtained from our lab. Aft

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Ho, Yih, and 何意. "Hypoglycemic effect of Anoectochilus formosanus extract and its inhibition of PD-L1 related genes expression in cancer cells." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/ek94qj.

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Yang, Lin, and 楊霖. "Antioxidant Activity of Royal Jelly and its Hypoglycemic Effect on High-Fat Diet and STZ-induced Diabetic Mice." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/shwp6c.

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碩士<br>國立虎尾科技大學<br>生物科技系碩士班<br>106<br>The purpose of this study was to investigate the effect of royal jelly on blood glucose levels in diabetic mice on high-fat diet and Streptozotocin (STZ)-induced and its anti-oxidative function. The analysis anti-oxidative activity include DPPH radical scavenging activity, reducing power activity, ferrous ions chelating effects. Also test the total phenols and total flavonoids. Diabetes experiment divided into two parts of royal jelly and different molecular weight of royal jelly. All male BALB/c mice were used as experimental animals. Nicotinamide (230mg/k

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Chiou, Ru-Bi, and 邱如璧. "Antioxidant Activity of Pumpkin (Cucurbita moschata) Extract and its Hypoglycemic Effect on High-Fat Diet and STZ-induced Diabetic Mice." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/23d4sm.

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碩士<br>國立虎尾科技大學<br>生物科技研究所<br>103<br>Pumpkins belong to the family of Cucurbitaceae. It is world famous and a wide range of ingredients in summer season. Hypoglycaemic and antioxidant effects of Pumpkin extract on high-fat diet streptozotocin-induced diabetic mice in this study. The analysis antioxidative activity include DPPH radical scavenging activity, ferrous ions chelating effects, reducing power activity, total polyphenols, total flavonoids and trolox equivalent antioxidant activity. The C. moschata extracts also was used to feed diabetic mices for the analysis hypoglycemic effects. The a

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Lee, Yu-Chen, and 李育臣. "Electroacupuncture at the Zusanli (ST-36) Acupoint Induces a Hypoglycemic Effect by Stimulating the Cholinergic Nerve in a Rat Model of Streptozotocine-Induced Insulin-Dependent Diabetes Mellitus." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/58006148886172431989.

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博士<br>中國醫藥大學<br>中醫學系博士班<br>99<br>Animal studies have shown that electroacupuncture (EA) at Zusanli (ST-36) and Zhongwan (CV-12) acupoints reduces plasma glucose concentrations in rats with type II diabetes. However, whether EA reduces plasma glucose levels in type I diabetes is still unknown. In this study, we explore the various non-insulin-dependent pathways involved in EA-induced lowering of plasma glucose. Streptozotocin (STZ) (60 mg kg-1, i.v.) was administered via the femoral vein to induce insulin-dependent diabetes in non-adrenalectomized and in adrenalectomomized rats. EA (15Hz) was a

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Jye, Jou Sheng, and 周聖杰. "1. Studies on the Chemical Constituents from the Stem of Alphitonia philippinensis. 2. Analyses on the Hypoglycemic Effect of Folk Medicine, WFT.3. An Improved Oxidative Cleavage Method for Large Scale Preparation of Cycloastragenol from Radix Astragali." Thesis, 2003. http://ndltd.ncl.edu.tw/handle/40801739962384146747.

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博士<br>國立臺灣大學<br>藥學研究所<br>91<br>英文摘要 I. Studies on the Chemical Constituents from the Stem of Alphitonia philippinensis. II. Analyses on the Hypoglycemic Effect of Folk Medicine, WFT. III. An Improved Oxidative Cleavage Method for Large Scale Preparation of Cycloastragenol from Radix Astragali. Part I： Cumulative phytochemical studies on rhamnaceous plants had indicated the presence of bioactive peptide alkaloids, benzylcoumarones, triterpenoids (saponins) and phenolic compounds. Hence we continued to investigate the chemical constituents o

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Neves, Mariana Vendeirinho. "Effects of hypoglycemia on vascular reactivity." Master's thesis, 2016. http://hdl.handle.net/10451/35881.

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Trabalho Final de Mestrado Integrado, Ciências Farmacêuticas, Universidade de Lisboa, Faculdade de Farmácia, 2016<br>Background: Hypoglycemia is a life threatening condition characterized by low blood glucose levels and it is capable to induce failure of organ function and their damage. It has been shown that hypoglycemia impairs acetylcholine-induced relaxation. However, it is not known how hypoglycemia changes the response of blood vessels to other physiological vasodilatators and vasoconstrictors. Aim of the study: To study the effects of hypoglycemia on vascular reactivity to physiologi

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Tseng, Chien-Jung, and 曾千容. "The Hypoglycemic Effects of Dioscorea TuberCultivated in Taiwan." Thesis, 2005. http://ndltd.ncl.edu.tw/handle/10485937705147416720.

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碩士<br>高雄醫學大學<br>天然藥物研究所碩士班<br>93<br>Dioscorea tuber has been used in medical treatment and functional food for thousand years. In this study, hypoglycemic activity was detected in polysaccharide-enriched fractions (PLE) and hot water extracts (HWE) of five kinds of Dioscorea tubers cultivated in Taiwan (numbers and origins: TA01: Dioscorea alata L., TA02: D. alata L., TA03: D. alata L. var. purpurea (Roxb.) M. Pouch., TA04: D. persimilis Prain et Burk. and TA05: D. alata L.) using streptozotocin (STZ) induced diabetic mouse/rat models. Animals showing blood glucose levels 250~300 mg/dL 48 h a

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Li, Chao-Chu, and 李朝珠. "Combination of Metformin and Momordica Charantia On in Vivo Hypoglycemic Effecct." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/98377404829021433574.

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碩士<br>大仁科技大學<br>製藥科技研究所<br>103<br>Nowadays, health foods or scientific herb medicines which contain triterpenes can be generally seen. These medicines are indicated to possess antioxidational material or activity in numerous researches. In this research, the pharmacokinetics maximum absorbing ratio and interaction with wild bitter melon (Momordica charantia Linn.) and metformin had been studied. Metformin be utilized with wild bitter melon which is the traditional medicine has hypoglycemic efficiency. The experiment of antioxidational analysis,Such as Scavenging of DPPH free radical was pe

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Karimi, Pour Alireza. "The Effect of Hypoglycemia on the Functional and Pathological Outcome of the Newborn Rat." Master's thesis, 2010. http://hdl.handle.net/10048/885.

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Controversy remains about the contribution of hypoglycemia to brain damage in the newborn. Therefore, the objective of this study was to determine the effects of isolated hypoglycemia on damage to the immature rat brain. Seven-day-old rats, equivalent to a late preterm human newborn, were placed in either Sham or hypoglycemic groups. Hypoglycemia was induced by insulin infusion for variable periods of time. Outcomes were assessed by behavioral, neurochemical and neuropathologic determination. Rats were categorized as having mild, moderate, or severe hypoglycemia. Behavioral tests revealed

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Wang, Ruoh-Yuh, and 王若昱. "Hypoglycemic and Antioxidative Effects of Glossogyne Tenuifolia in Streptozotocin–Nicotinamide-induced Diabetic Rats." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/16203248029104836466.

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碩士<br>輔仁大學<br>營養科學系碩士班<br>101<br>The global prevalence of diabetes mellitus (DM) is increasing rapidly in recent years, and disease ranked among the top ten leading causes of death in Taiwan. Glossogyne tenuifolia (GT), a native plant of Penghu, Taiwan, is usually used as an herbal tea. Recent researches have been shown that the active components in GT are potential inhibitors of α-glucosidase. The present study investigated that whether or not GT could improve the status of type 2 DM. The effects of GT extracts derived from various solvents (95% ethanol, 50% ethanol and hot water) on the inhi

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Peng, Chih-Ting, and 彭稚庭. "Hypoglycemic and hypolipidemic effects of Hedyotis diffusa in streptozotocin-nicotinamide-induced diabetic rats." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/61471649012478893987.

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碩士<br>輔仁大學<br>營養科學系碩士班<br>103<br>Hedyotis diffusa (HD) is a well-known Chinese folk medicine. Previous research has shown that HD has many potentially beneficial health effects including antioxidant, anti-tumor and immunomodulatory activities. Recent studies found that oleanolic acid and ursolic acid, the main phenolic compounds in HD, can reduce blood glucose by inhibiting gluconeogenesis in diabetic rats. Therefore, the present study investigated the hypoglycemic effects of Hedyotis diffusa in streptozotocin-nicotinamide-induced diabetic rats. The HD extracts derived from various solvents (

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Cheng, Chia-Hsin, and 鄭佳欣. "Study for the molecular mechanism underlying the hypoglycemic effects of Momordica charantia triterpenes." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/74989628543880767470.

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碩士<br>國立屏東科技大學<br>生物科技研究所<br>98<br>The occurrence of type 2 diabetes is closely associated with the development of insulin resistance. Previously, two triterpenes, CH63 and CH93, were isolated from the extract of the stem of Momordica charantia. They were proved to promote glucose uptake, activate the insulin signaling pathway and AMP-activated protein kinase (AMPK) in insulin-resistant cells. Therefore, CH63 and CH93 were considered to be hypoglycemic molecules. The purpose of this study is to further explore the molecular mechanisms underlying the hypoglycemic activitise of CH63 and CH93. In

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