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Journal articles on the topic 'Hypoglycemic effect'

Author: Grafiati

Published: 2 June 2025

Last updated: 19 July 2025

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1

Pogonea, Ina, Tatiana Chiriac, Carolina Catcov, Maria Mihalachi-Anghel, and Liviu Mereacre. "Drugs with secondary hypoglycemic effect." Public Health, Economy and Management in Medicine, no. 5(102) (November 2024): 96–103. https://doi.org/10.52556/2587-3873.2024.5(102).15.

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The problem of hypoglycemia induced by non-diabetic drugs, which is increasingly reported, has been studied. The hypoglycemic side effect of drugs is explained by different mechanisms and manifests individually depending on age, gender, comorbidities. A special role belongs to the associated administration of drugs and the interaction between them. Data from the specialized literature (case reports and medical databases) were selected and analyzed, with the aim of identifying drugs with hypoglycemic potential, mechanisms of action, associated risk factors, including strategies of prevention an

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Fruehwald-Schultes, Bernd, Werner Kern, Eva Deininger, et al. "Protective Effect of Insulin against Hypoglycemia-Associated Counterregulatory Failure." Journal of Clinical Endocrinology & Metabolism 84, no. 5 (1999): 1551–57. http://dx.doi.org/10.1210/jcem.84.5.5675.

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Antecedent hypoglycemic episodes reduce the counterregulatory neuroendocrine response to hypoglycemia. The role of insulin in the mechanism responsible for the antecedent hypoglycemia causing subsequent counterregulatory failure has not been elucidated. We performed antecedent hypoglycemic clamps (56 mg/dL) lasting 2 h with differing degrees of hyperinsulinemia, which were followed by 6-h stepwise hypoglycemic clamps (76–66–56–46 mg/dL) on the next day. Experiments were carried out in 30 young, healthy men. Fifteen of these subjects were tested on 2 occasions. On 1 occasion the antecedent hypo

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Okazaki, Moemi, Masafumi Okazaki, Miho Nakamura, Tadashi Asagiri, and Seisho Takeuchi. "Consecutive hypoglycemia attacks induced by co-trimoxazole followed by pentamidine in a patient with acquired immunodeficiency syndrome." International Journal of STD & AIDS 30, no. 1 (2018): 86–89. http://dx.doi.org/10.1177/0956462418795580.

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Both co-trimoxazole and pentamidine are used for the treatment of pneumocystis pneumonia (PCP) and are known to cause hypoglycemia as an adverse drug reaction. Here, we describe a rare case of a late-diagnosed female patient with acquired immunodeficiency syndrome (AIDS) who developed the first hypoglycemic attack as an adverse effect of co-trimoxazole, followed by a second hypoglycemic attack as an adverse effect of pentamidine. Physicians caring for patients with AIDS and PCP should be aware of possible hypoglycemia in patients with many risk factors.

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Chen, Nai-Ching, Chien-Liang Chen, and Feng-Chih Shen. "The Risk Factors of Severe Hypoglycemia in Older Patients with Dementia and Type 2 Diabetes Mellitus." Journal of Personalized Medicine 12, no. 1 (2022): 67. http://dx.doi.org/10.3390/jpm12010067.

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Background: The adequate glycemic control and risk factors for hypoglycemia in older patients with dementia and type 2 diabetes mellitus (T2DM) remain unclear. This study aimed to analyze the status of glycemic control and determine the risk of hypoglycemia among these groups. Methods: A hospital admission record due to hypoglycemia through an emergency room with glucose supplementation in the Chang Gung Memorial Hospital was identified as a hypoglycemic event. Patients with dementia and T2DM without hypoglycemic events throughout the study period were defined as the control group. We gathered

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Flores Fiallos, Linda Mariuxi, Juan José Flores Fiallos, Adriana Isabel Rodríguez Basantes, María Augusta Guadalupe Alcoser, and Sofía Carolina Godoy Ponce. "Actividad hipoglucémica de las hojas de Yaca (Artocarpus heterophyllus Lam)." Bionatura 8, no. 3 (2023): 1–7. http://dx.doi.org/10.21931/rb/2023.08.03.10.

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Currently, alternatives to the use of drugs to counteract hypoglycemia are being sought through the use of natural medicine. In this sense, this article evaluates the hypoglycemic effect of hydroalcoholic and aqueous extracts of jackfruit leaves (Artocarpus heterophyllus Lam), based on an analysis in experimental models, Rattus rats. Extracts were prepared with concentrations of 125, 250 and 400 ppm. The hypoglycemic analysis was carried out over 15 days, using 45 male rats divided into 9 groups: target, negative control, and positive control. The 8 groups, except for the target group, were ad

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Hao, Zhenzhen, Chenchen Li, Jing Li, Yan Gao, Li Guo, and Qian Wang. "Analysis of the Causes of Hypoglycemic Reactions in Patients with Diabetic Nephropathy during the Peri-dialysis Period." International Journal of General Practice Nursing 3, no. 1 (2025): 28–31. https://doi.org/10.26689/ijgpn.v3i1.9719.

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Objective: To provide clinical evidence for controlling the incidence of hypoglycemia in patients with diabetic nephropathy during the peri-dialysis period by analyzing the causes of hypoglycemic reactions in diabetic patients during this period in the hospital. Methods: A total of 56 patients with diabetic nephropathy in the peri-dialysis period (i.e., glomerular filtration rate eGFR < 15ml/(min*1.73 m2) up to three months after dialysis) who received outpatient, inpatient, and hemodialysis treatments in the hospital from June 2022 to December 2023 were selected as the research subjects. T

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7

Sanders, Nicole M., Charles W. Wilkinson, Gerald J. Taborsky, et al. "The selective serotonin reuptake inhibitor sertraline enhances counterregulatory responses to hypoglycemia." American Journal of Physiology-Endocrinology and Metabolism 294, no. 5 (2008): E853—E860. http://dx.doi.org/10.1152/ajpendo.00772.2007.

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Selective serotonin reuptake inhibitors (SSRIs) are widely prescribed for patients with comorbid diabetes and depression. Clinical case studies in diabetic patients, however, suggest that SSRI therapy may exacerbate hypoglycemia. We hypothesized that SSRIs might increase the risk of hypoglycemia by impairing hormonal counterregulatory responses (CRR). We evaluated the effect of the SSRI sertraline on hormonal CRR to single or recurrent hypoglycemia in nondiabetic rats. Since there are time-dependent effects of SSRIs on serotonin neurotransmission that correspond with therapeutic action, we eva

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Haas, Andrea, Rebecca Easly, Andrew Koefoed, et al. "Hypoglycemia Impairs Baroreflex Sensitivity: Implications for Autonomic Control of Cardiovascular Function in Diabetes." Journal of the Endocrine Society 5, Supplement_1 (2021): A447—A448. http://dx.doi.org/10.1210/jendso/bvab048.915.

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Abstract Background: Iatrogenic hypoglycemia is an unintended, though common, occurrence in individuals with diabetes. There is a clear association between hypoglycemia exposure and an increase in mortality in individuals with type 2 diabetes (T2DM). It is well-established that recurrent hypoglycemic episodes impair the counterregulatory hormone responses; however, it is yet to be determined if in T2DM there are more global effects of hypoglycemia on autonomic control of cardiovascular function (baroreflex sensitivity, BRS), as has been shown in healthy individuals. This is a clinically releva

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Büyükkaya Besen, Dilek, Hamdiye Arda Sürücü, and Cansu Koşar. "Self-reported frequency, severity of, and awareness of hypoglycemia in type 2 diabetes patients in Turkey." PeerJ 4 (December 13, 2016): e2700. http://dx.doi.org/10.7717/peerj.2700.

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ObjectivesHypoglycemia is a common side effect of insulin therapy in type 1 and type 2 diabetes. Limited data exist on the frequency of hypoglycemic events in type 2 diabetic patients in Turkey. Our study investigated self-reported hypoglycemic events and awareness of hypoglycemia in Turkish patients with type 2 diabetes.MethodsPeople with type 2 diabetes older than 18 years of age were recruited from the two university hospital diabetes clinics. The frequency and severity of hypoglycemia and awareness of hypoglycemia during the preceding year were determinated using questionnaires by the face

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Hekimsoy, Zeliha, Sevinç Biberoǧlu, Abdurrahman Çömlekçi, Oktay Tarhan, Cem Mermut, and Kadir Biberoǧlu. "Trimethoprim/sulfamethoxazole-induced hypoglycemia in a malnourished patient with severe infection." European Journal of Endocrinology 136, no. 3 (1997): 304–6. http://dx.doi.org/10.1530/eje.0.1360304.

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Abstract Hypoglycemia resulting from the combination of sulfonylurea and sulfonamides is a recognized drug interaction. Hypoglycemia induced by sulfonamides alone may be encountered less frequently. Because of their structural similarities to sulfonylureas. sulfonamides are liable to facilitate hypoglycemia by increasing insulin release in susceptible individuals. Sulfonamides can potentiate the hypoglycemic effect of sulfonylurea agents when given in combination. We describe a malnourished patient with severe infection who developed hypoglycemia during high-dose trimethoprim/sulfamethoxazole

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Fruehwald-Schultes, Bernd, Werner Kern, Kerstin M. Oltmanns, et al. "Metformin Does Not Adversely Affect Hormonal and Symptomatic Responses to Recurrent Hypoglycemia." Journal of Clinical Endocrinology & Metabolism 86, no. 9 (2001): 4187–92. http://dx.doi.org/10.1210/jcem.86.9.7790.

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Body weight gain and severe hypoglycemia are the major adverse effects of insulin therapy in type 2 diabetic patients. Metformin has been shown to prevent insulin therapy-induced body weight gain when used in combination with insulin. However, the effects of metformin on hormonal and symptomatic responses to hypoglycemia mediating hypoglycemia awareness have not been assessed to date. Fifteen young healthy men were treated with 850 mg metformin and placebo twice daily for a 16-d period in a double blind, cross-over design. On the last 2 d of the treatment period, the subjects underwent three h

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Passias, T. C., G. S. Meneilly, and I. B. Mekjavic. "Effect of hypoglycemia on thermoregulatory responses." Journal of Applied Physiology 80, no. 3 (1996): 1021–32. http://dx.doi.org/10.1152/jappl.1996.80.3.1021.

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The effects of hypoglycemia on sweating, skin blood perfusion, and shivering responses were investigated in 10 healthy male volunteers. They exercised on an underwater cycle ergometer while immersed to the neck in 28 degrees C water for 20 min at 50% of their maximal work rate. The exercise-induced elevation in esophageal temperature (T(es)) initiated the sweating response (Esw) and increased skin blood perfusion (SkBP) as measured at the forehead. In the 99-min postexercise immersion period, the values of T es relative to resting level (delta T(es)) at which Esw abated, SkBP reached preexerci

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Bach, Quyen N., Rod A. Gilmore, Melody C. Sheffield, and W. Anthony Hawkins. "Evaluation of Insulin Use and Hypoglycemia in Hospitalized Elderly Patients." Hospital Pharmacy 52, no. 11 (2017): 761–65. http://dx.doi.org/10.1177/0018578717735974.

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Background: Routine administration of correctional insulin is no longer recommended as a primary strategy to treat hyperglycemia in hospitalized patients. Studies have demonstrated significant improvement in glycemic control in patients treated with basal and correctional insulin (B+C) versus correctional insulin alone (C). However, the effect of C or B+C on hypoglycemic events is not well understood. Objective: The objective of this study was to investigate the effect of B+C versus C on hypoglycemic events in hospitalized elderly patients. Methods: A single-center retrospective review of pati

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Dessouky, Arigue A., Zienab A. Gouda, Mona A. A. Arafa, Yaser H. A. Elewa, Amany M. Abo-Ouf, and Eman M. Askar. "Hypoxia-Preconditioned Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells Mitigate Hypoglycemic Testicular Injury Induced by Insulin in Rats." Cells Tissues Organs 209, no. 2–3 (2020): 83–100. http://dx.doi.org/10.1159/000510363.

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Hypoglycemia is a neglected metabolic disorder. Thus, we evaluated the protective effect of hypoxia-preconditioned human umbilical cord blood-derived mesenchymal stem cells (hUCB-MSCs) on hypoglycemic testicular injury. We examined 56 testes from 28 animals: 7 rats with insulin-induced hypoglycemia (HG group), 7 hypoglycemic rats which received an intratesticular injection of hUCB-MSCs (HG-MSC group), and 14 untreated control rats. Testosterone level, testicular catalase (CAT) activity, and malondialdehyde (MDA) level were analyzed. Immunostaining for specific testicular germ and somatic cell

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Kim, Young-Baeg, Jeffrey M. Gidday, Ernesto R. Gonzales, Aarti R. Shah, and T. S. Park. "Effect of hypoglycemia on postischemic cortical blood flow, hypercapnic reactivity, and interstitial adenosine concentration." Journal of Neurosurgery 81, no. 6 (1994): 877–84. http://dx.doi.org/10.3171/jns.1994.81.6.0877.

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✓ Hypoglycemia increases the vulnerability of the perinatal brain to asphyxia, but it is not known if hypoglycemia-induced changes in cerebral hemodynamics and vascular reactivity underlie this vulnerability. This study tested the hypothesis that hypoglycemia exacerbates postischemic hypoperfusion, and impairs postischemic CO2 reactivity. The authors also examined the hypothesis that postischemic hypoperfusion is associated with a reduction in the interstitial concentration of the vasodilator metabolite adenosine. Global cerebral ischemia of 10 minutes duration was induced in newborn pigs anes

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Hanggaresty, Mutiarani Dasha, and Ni Kadek Warditiani. "REVIEW OF POTENTIAL PLANTS IN INDONESIA AS AN ANTIDIABETIC WITH HYPOGLYCEMIC ACTIVITIES." Journal of Pharmaceutical Science and Application 3, no. 2 (2021): 57. http://dx.doi.org/10.24843/jpsa.2021.v03.i02.p01.

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Background: Diabetes mellitus which is characterized by hyperglycemia is a metabolic disease due to insulin action, defects in insulin secretion, or both. Various studies have shown that herbs that have a hypoglycemic effect can be used in the treatment of diabetes mellitus. Generally, herbs can slow down the complications of diabetes mellitus and improve metabolism. The ability of plants to restore the function of pancreatic tissue to increase insulin production or make it easier for insulin to process glucose is related to the effects of hypoglycemia. Objective: Comparing plants that have a

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Petunina, N. A., N. S. Martirosian, E. V. Goncharova, et al. "The place of gliclazide MB in modern treatment strategies for patients with type 2 diabetes mellitus." Diabetes mellitus 27, no. 4 (2024): 368–75. http://dx.doi.org/10.14341/dm13184.

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Sulfonylurea (SU) are an effective class of oral hypoglycemic drugs that have been used in clinical practice for more than 70 years. Despite the common mechanism of action, members of the class have significant intraclass differences in hypoglycemic activity, safety, and the presence of extrapancreatic effects. This review examines the features of gliclazide modified release (MR), its differences from other representatives of the SU and its place in modern recommendations for the treatment of type 2 diabetes mellitus. Gliclazide MR belongs to the modern 2nd generation SU with high hypoglycemic

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Wu, Suyan, Haifei Pan, and Yingying Huang. "Pharmacokinetic interaction of saxagliptin with andrographolide and their hypoglycemic effect in type 2 diabetes rats." Acta Poloniae Pharmaceutica - Drug Research 80, no. 4 (2023): 667–73. http://dx.doi.org/10.32383/appdr/170911.

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Controlling blood glucose is the primary therapeutic strategy for T2DM. Both saxagliptin and andrographolide possess hypoglycemic effects, which makes the combination easy. This study aimed to evaluate the co-administration of saxagliptin and andrographolide in rats and revealed their combined impact on type 2 diabetes (T2DM). T2DM rat models were established by high-fat diet and the injection of nicotinamide and streptozotocin. The blood glucose and insulin resistance index were monitored after modeling. The pharmacokinetics of saxagliptin was assessed by orally administrating 10 mg/kg saxagl

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Nedosugova, Lyudmila Viktorovna. "Sulfonylureas in the modern strategy of therapy of type 2 diabetes." Diabetes mellitus 14, no. 2 (2011): 99–109. http://dx.doi.org/10.14341/2072-0351-5645.

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Type 2 diabetes mellitus (DM2) is a chronic progressing disease associated with insulin resistance and impaired insulin secretion insufficient toovercome insulin resistance that deteriorates as a result of glucose toxicity and beta-cell apoptosis. Combination of metformin and sulfonylureas (SU) iscurrently regarded as an effective strategy of hypoglycemic therapy having effect not only on the main stages of pathogenesis but also on t dangerousrisk factors leading to adverse events (hypoglycemia, body weight increment, cardiovascular disorders). Amaryl, SU of the 3d generation, meets allcriteri

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Almby, Kristina E., Niclas Abrahamsson, Martin H. Lundqvist, et al. "Effects of GLP-1 on counter-regulatory responses during hypoglycemia after GBP surgery." European Journal of Endocrinology 181, no. 2 (2019): 161–71. http://dx.doi.org/10.1530/eje-19-0171.

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Objectives The aim of the study was to explore the role of GLP-1 receptor activation on the counter-regulation and symptoms of hypoglycemia in subjects who have undergone gastric bypass surgery (GBP). Design Experimental hyperinsulinemic–hypoglycemic clamp study. Methods Twelve post-GBP subjects participated in a randomized cross-over study with two hyperinsulinemic, hypoglycemic clamps (glucose nadir 2.7 mmol/L) performed on separate days with concomitant infusions of the GLP-1 analog exenatide or with saline, respectively. Continuous measurements of metabolites and counter-regulatory hormone

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Kadoya, Fumito, Akira Mitani, Tatsuru Arai, and Kiyoshi Kataoka. "Effects of Propentofylline on Hypoxia—Hypoglycemia-Induced Calcium Accumulation in Gerbil Hippocampal Slices." Journal of Cerebral Blood Flow & Metabolism 12, no. 2 (1992): 301–5. http://dx.doi.org/10.1038/jcbfm.1992.41.

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The xanthine derivative propentofylline (HWA 285) has been reported to show protective effects against neuronal damage induced by cerebral ischemia. In the present study, microfluorometry was used to investigate the effect of propentofylline on the hypoxia–hypoglycemia-induced intracellular calcium accumulation in gerbil hippocampal slices. When slices were superfused with hypoxic–hypoglycemic medium that did not contain propentofylline, an acute increase in calcium accumulation was detected 75–200 s (mean latency of 123 s) after the beginning of hypoxia–hypoglycemia. When slices were superfus

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Clowes, Jackie A., Robert T. Robinson, Simon R. Heller, Richard Eastell, and Aubrey Blumsohn. "Acute Changes of Bone Turnover and PTH Induced by Insulin and Glucose: Euglycemic and Hypoglycemic Hyperinsulinemic Clamp Studies." Journal of Clinical Endocrinology & Metabolism 87, no. 7 (2002): 3324–29. http://dx.doi.org/10.1210/jcem.87.7.8660.

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Bone turnover is acutely suppressed after feeding or oral glucose. Insulin infusion suppresses bone turnover and might mediate this effect, but this is confounded by a possible direct effect of hypoglycemia. We examined the effect of euglycemic hyperinsulinemia and hypoglycemic hyperinsulinemia on bone turnover using an insulin clamp. Sixteen men participated in this double-blind crossover study. Clamp induction involved infusion of insulin (80 mU/m2·min) while maintaining euglycemia (5 mmol/liter) for 40 min with a variable rate dextrose infusion. Glucose was lowered to 2.5 mmol/liter (hypogl

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Dozio, Nicoletta, Marina Scavini, Angelo Beretta, et al. "Imaging of the Buffering Effect of Insulin Antibodies in the Autoimmune Hypoglycemic Syndrome1." Journal of Clinical Endocrinology & Metabolism 83, no. 2 (1998): 643–48. http://dx.doi.org/10.1210/jcem.83.2.4599.

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Insulin autoimmune hypoglycemia is characterized by recurrent hypoglycemia and high levels of immunoreactive insulin in the presence of insulin autoantibodies. The mechanisms inducing hypoglycemia are largely unknown. An [123I]insulin scintigraphic scanning was performed to directly demonstrate the effect of antibodies on insulin biodistribution in one patient with this syndrome both before and after treatment. The patient had insulin autoantibodies IgG3 λ, which had a single site dissociation constant (Kd = 10−7 mol/L, by Scatchard analysis), a very fast dissociation rate of immune complexes,

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Jamal, Roohi, D. K Suresh, and Md S Khalid. "Influence of temsirolimus on antidiabetic effect of sitagliptin in experimental animal." International Journal of Pharmacology and Toxicology 6, no. 2 (2018): 24. http://dx.doi.org/10.14419/ijpt.v6i2.11819.

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The present study was carried out to evaluate the drug interaction between an antihyperglycemic agent and anticancerous drug,In healthy and Dexamethasone induced diabetic rats. The blood samples were collected up to 24 h and blood glucose level was estimated. In healthy albino rats Pretreatment with Temsirolimus (6.75 mg/kg for seven days) has significantly altered the onset of hypoglycemia (15.50+1.47 to21.40±.54), p< 0.001 at the 2nd hour significantly enhanced the peak hypoglycemia (29.70+.60 %) before treatment to (44.47+1.21 %) after treatment(p<0.001) at 4th hour (i.e. 18.71±.38 to

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Ionut, Viorica, Ana Valeria B. Castro, Orison O. Woolcott, et al. "Essentiality of Portal Vein Receptors in Hypoglycemic Counterregulation: Direct Proof Via Denervation in Male Canines." Endocrinology 155, no. 4 (2014): 1247–54. http://dx.doi.org/10.1210/en.2013-1794.

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A major issue of in the treatment of diabetes is the risk of hypoglycemia. Hypoglycemia is detected both centrally and peripherally in the porto-hepatic area. The portal locus for hypoglycemic detection was originally described using the “local irrigation of the liver” approach in a canine model. Further work using portal vein denervation (DEN) in a rodent model characterized portal hypoglycemic sensing in detail. However, recent controversy about the relevance of rodent findings to large animals and humans prompted us to investigate the effect of portal DEN on the hypoglycemic response in the

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NAKINCHAT, Somrudee, and Voravuth SOMSAK. "A Pilot Study on Antimalarial Effects of Moringa oleifera Leaf Extract in Plasmodium berghei Infection in Mice." Walailak Journal of Science and Technology (WJST) 15, no. 2 (2017): 151–56. http://dx.doi.org/10.48048/wjst.2018.4593.

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The emergence and spread of antimalarial drug resistance of Plasmodium parasites, as well as hypoglycemia, during malaria infection, and subsequent death, are critical problems in malaria-endemic areas. Hence, finding new compounds, especially plant extracts having antimalarial and anti-hypoglycemic activities, are urgently needed. The present study aimed to investigate the antimalarial and anti-hypoglycemic effects of Moringa oleifera leaf extract in Plasmodium berghei infection in mice. Aqueous crude extract of M. oleifera leaves was freshly prepared and used for an efficacy test in vivo. Gr

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Carrera, Perliveh, and Vivek N. Iyer. "Profound Hypoglycemia with Ecstasy Intoxication." Case Reports in Emergency Medicine 2015 (2015): 1–2. http://dx.doi.org/10.1155/2015/483153.

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Background.3,4-Methylenedioxymethamphetamine (MDMA) or ecstasy is a synthetic drug that is commonly abused for its stimulant and euphoric effects. Adverse MDMA effects include hyperthermia, psychomotor agitation, hemodynamic compromise, renal failure, hyponatremia, and coma. However, endogenous hyperinsulinemia with severe persistent hypoglycemia has not been reported with MDMA use.Case Report.We report the case of a 29-year-old woman who remained severely hypoglycemic requiring continuous intravenous infusion of high-dose dextrose solutions for more than 24 hours after MDMA intoxication. Seru

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Khedkar, Jyotsna Pandit, Prashant Suresh Salunke, Harshal Dilip Mahajan, Tanvirahmad Jamaloddin Shaikh, Mayur Ashok Bagul, and Ujwal Hansraj Patil. "Effects of Amiodarone on the Glucose Lowering Effect of Glimepiride: An Animal Experiment." UTTAR PRADESH JOURNAL OF ZOOLOGY 45, no. 19 (2024): 189–95. http://dx.doi.org/10.56557/upjoz/2024/v45i194516.

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The purpose of the current study was to ascertain how the antiarrhythmic drug amiodarone, which was given to normal and diabetic rats in numerous doses over seven days, affected the hypoglycemic effect of glimepiride. Finding the medication interaction between glimepiride and amiodarone in rats was the aim of the study. Six healthy and six diabetic rats of both sexes participated in these investigations. Amiodarone (50 mg/kg body weight) and glimepiride (0.41 mg/kg) were the medication doses provided. Oral administration of the drug was used. Blood samples were taken from the tail vein at prea

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Horii, Takeshi, Mai Otsuka, and Takeo Yasu. "Risk of non-hypoglycemic agents for hypoglycemia-related hospitalization in patients with type 2 diabetes: a large-scale medical receipt database analysis." BMJ Open Diabetes Research & Care 11, no. 2 (2023): e003177. http://dx.doi.org/10.1136/bmjdrc-2022-003177.

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IntroductionHypoglycemia is listed as an adverse effect in the package inserts of not only hypoglycemic agents but also many other drugs. We aimed to clarify real-world factors related to an increased risk of hypoglycemia-related hospitalization (HRH) in Japanese patients with type 2 diabetes (T2D) on non-hypoglycemic agents that have been associated with hypoglycemia.Research design and methodsThis cross-sectional study was performed using data from the Medical Data Vision administrative claims database. We identified patients with T2D who were enrolled in the database between April 2014 and

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K.C., Indu. "Causes of Hypoglycemia in Hospitalized Diabetic Patients Referred to Endocrine Department of a Tertiary Level Hospital of India." Medical Journal of Shree Birendra Hospital 15, no. 1 (2016): 26–31. http://dx.doi.org/10.3126/mjsbh.v15i1.15018.

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Introduction: Diabetes mellitus (DM) results from relative deficiency or reduced effectiveness of endogenous insulin leading to both micro-vascular and macro-vascular complications. Treatment goal is intensive therapy as early as possible in patients with both type-1 and type-2 diabetes to bring the HbA1c to less than 7%. Occurrence of hypoglycemia in a diabetic patient is a common side effect of treatment. This study was aimed to find the causes of Hypoglycemia in diabetes patients. Methods: It was hospital based cross-sectional observational study on admitted diabetes patients with other co-

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Hunt, Neil T. "Hypoglycemic effect of lithium." Biological Psychiatry 22, no. 6 (1987): 798–99. http://dx.doi.org/10.1016/0006-3223(87)90219-8.

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Zuern, Allison, Luke A. Probst, William Darko, et al. "Effect of a Standardized Treatment Panel on Hypoglycemic Events in Hospitalized Acute Hyperkalemic Patients Treated With Intravenous Regular Insulin." Hospital Pharmacy 55, no. 4 (2019): 240–45. http://dx.doi.org/10.1177/0018578719841035.

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Purpose: Regular insulin is a commonly utilized treatment option for acute hyperkalemia. Despite its benefit, hypoglycemia and associated morbidity/mortality remain important concerns. This institution recently created a treatment panel to standardize regular insulin dosing (0.1 unit/kg) and blood glucose (BG) monitoring in patients with acute hyperkalemia. The purpose of this study is to investigate whether the order panel reduces hypoglycemic events in adults treated with intravenous (IV) regular insulin for hyperkalemia and to determine the effect the treatment panel has on regular insulin

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Manandhar Shrestha, Jyoti Tara, Himal Shrestha, Miyasha Prajapati, Astha Karkee, and Aman Maharjan. "Adverse Effects of Oral Hypoglycemic Agents and Adherence to them among Patients with Type 2 Diabetes Mellitus in Nepal." Journal of Lumbini Medical College 5, no. 1 (2017): 34. http://dx.doi.org/10.22502/jlmc.v5i1.126.

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Introduction: Oral hypoglycemic agents (OHAs) are the most common drugs used in Type 2 Diabetes Mellitus. There are various established adverse effects related to their use including hypoglycemia, weight gain, gastrointestinal disturbance, lactic acidosis, and fluid retention. However, the pattern of adverse effects related to OHAs in Nepalese patients still needs to be explored. Our study aims to determine the pattern of adverse effects resulting from the use of OHAs among Type 2 Diabetes mellitus patients and their adherence to the medication. Methods: All diabetic patients who met the

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Davis, S. N., and D. Tate. "Effects of Morning Hypoglycemia on Neuroendocrine and Metabolic Responses to Subsequent Afternoon Hypoglycemia in Normal Man1." Journal of Clinical Endocrinology & Metabolism 86, no. 5 (2001): 2043–50. http://dx.doi.org/10.1210/jcem.86.5.7495.

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There is general agreement that prior hypoglycemia blunts subsequent hypoglycemic counterregulatory responses. However, there is considerable debate concerning the timing and number of prior hypoglycemic episodes required to cause this blunting effect. The aim of this study was to determine whether one episode of hypoglycemia could modify neuroendocrine, metabolic, and symptom responses to hypoglycemia induced 2 h later. A total of 24 (12 male and 12 female) young, healthy, overnight-fasted subjects participated in a series of glucose clamp studies. A total of 16 individuals underwent 2 random

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Borisov, Sergey A., Olga A. Luzina, Mikhail V. Khvostov, Tatiana G. Tolstikova, and Nariman F. Salakhutdinov. "Synthesis and Pharmacological Evaluation of (+)-Usnic Acid Derivatives as Hypoglycemic Agents." Molbank 2022, no. 4 (2022): M1459. http://dx.doi.org/10.3390/m1459.

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Usnic acid is produced by lichens and exhibits different biological properties, including hypoglycemic ones. However, this effect becomes noticeable only at relatively high doses, something that may lead to some adverse effects. The chemical modification of the molecule is able to enhance its safety profile and its hypoglycemic properties. We synthesized six enamine derivatives of (+)-usnic acid, and two of them are novel. All compounds were evaluated for the hypoglycemic effect after oral introduction in mice with alloxan-induced diabetes mellitus at a dose of 50 mg/kg. The derivative contain

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Koussoube, Abdelaziz, Filkpièrè Léonard DA, Maya Doukoure, et al. "Assessment of antioxidant activity and hypoglycemic and anti-hyperglycemic effects of the hydroethanolic extract of the trunk bark of Lannea acida A. Rich. (Anacardiaceae) in male NMRI mice." International Journal of Research in Pharmaceutical Sciences 16, no. 2 (2025): 61–69. https://doi.org/10.26452/ijrps.v16i2.4755.

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Lannea acida A. Rich (Anacardiaceae) is a plant widely used in African traditional medicine to treat various ailments, including diabetes and infertility. This study aimed to evaluate the antioxidant, hypoglycemic, and anti-hyperglycemic activities of the hydroethanolic extract from its trunk bark in male NMRI mice. Antioxidant activity was assessed using DPPH (2,2-diphenyl-1-picrylhydrazyl) and ferric reducing antioxidant power (FRAP) assays. Hypoglycemic effects were tested in fasting normoglycemic mice divided into five groups (n=5). The anti-hyperglycemic activity was evaluated via an oral

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Boeder, Schafer C., Justin M. Gregory, Erin R. Giovannetti, and Jeremy H. Pettus. "SGLT2 Inhibition Increases Fasting Glucagon but Does Not Restore the Counterregulatory Hormone Response to Hypoglycemia in Participants With Type 1 Diabetes." Diabetes 71, no. 3 (2021): 511–19. http://dx.doi.org/10.2337/db21-0769.

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Individuals with type 1 diabetes have an impaired glucagon counterregulatory response to hypoglycemia. Sodium—glucose cotransporter (SGLT) inhibitors increase glucagon concentrations. We evaluated whether SGLT inhibition restores the glucagon counterregulatory hormone response to hypoglycemia. Adults with type 1 diabetes (n = 22) were treated with the SGLT2 inhibitor dapagliflozin (5 mg daily) or placebo for 4 weeks in a randomized, double-blind, crossover study. After each treatment phase, participants underwent a hyperinsulinemic-hypoglycemic clamp. Basal glucagon concentrations were 32% hig

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Sang, Zhen, Ligang Zhou, Xiaoning Fan, and Rory J. McCrimmon. "Radix astragali (Huangqi) as a Treatment for Defective Hypoglycemia Counterregulation in Diabetes." American Journal of Chinese Medicine 38, no. 06 (2010): 1027–38. http://dx.doi.org/10.1142/s0192415x10008445.

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Radix astragali is a herbal remedy used in China to treat patients with diabetes exposed to repeated episodes of hypoglycemia. The physiological basis or validity of this approach is not clear. In the present study, we examine the effect of pre-treatment with Radix astragali on hormonal counterregulatory responses to hypoglycemia in normal male Sprague-Dawley rats. Four groups of rodents were studied. In two of these groups, rodents were pre-treated for 3 days with either intravenous Radix astragali or control solution and, subsequently, while awake and unrestrained, underwent an in vivo hyper

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Tian, Qin, Ming Liang Yi, Jia Lu Wan, and Hong Yin. "Acute severe hypoglycemia immediately after induction of anesthesia in an elderly patient with type 2 diabetes mellitus: A case report." Medicine 102, no. 51 (2023): e36683. http://dx.doi.org/10.1097/md.0000000000036683.

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Rationale: Acute severe hypoglycemia immediately following anesthesia induction is a rare but life-threatening complication that is frequently underdiagnosed due to insufficient awareness. Among the various physiological processes influenced by opioids, alterations in blood glucose levels induced by opioids are a side effect that is commonly overlooked. The significance of this report lies in emphasizing the neglected association between opioids and hypoglycemia and highlighting the importance of close glucose monitoring to prevent hypoglycemic events in the perioperative setting. Patient conc

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Pashkova, E. Iu. "The new therapeutic modalities for the treatment of type 2 diabetes mellitus: insulin detemir added to liraglutide." Problems of Endocrinology 59, no. 4 (2013): 50–55. http://dx.doi.org/10.14341/probl201359450-55.

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he literature data on the effectiveness and safety of the essentially new scheme of hypoglycemic therapy of type 2 diabetes mellitus are presented, The large-scale 52 week study has demonstrated that the addition of insulin detemir to the preceding treatment with liraglutide makes it possible to reach and maintain glycated hemoglobin percentage at the desired level of 7% in 43% of the patients. The risk of development of hypoglycemia was estimated at 0.286 episodes per patient per year in the absence of body weight increment. The combination of these two medications was found to produce pronou

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Voĭchik, É. A. "Victosa: the experience with clinical application in patients with type 2 diabetes mellitus." Problems of Endocrinology 57, no. 3 (2011): 37–41. http://dx.doi.org/10.14341/probl201157337-41.

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Type 2 diabetes mellitus that comes from insulin resistance and deficit of insulin secretion has recently been described as associated with reduced incretin effect. The efficiency of traditional hypoglycemic therapy (metformin, secretagogues, glitazones, insulin) gradually decreases due to progressive loss of functioning beta-cell mass. The achievement of target blood glucose levels for the prevention of complications and cardiovascular pathology as a rule leads to such adverse events as increased body weight and hypoglycemia. The search for an «ideal» drug included the study and the use of in

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Hilleman, Daniel E., Syed M. Mohiuddin, Ismail S. Ahmed, and Joann M. Dahl. "Cibenzoline-Induced Hypoglycemia." Drug Intelligence & Clinical Pharmacy 21, no. 1 (1987): 38–40. http://dx.doi.org/10.1177/10600280870211p104.

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Antiarrhythmic-induced hypoglycemia is an ill-defined phenomenon. Sporadic cases have been reported with disopyramide, a class IA antiarrhythmic agent. We report a case of cibenzoline-induced hypoglycemia in an elderly male with a history of ischemic heart disease, congestive heart failure, ventricular arrhythmias, and chronic obstructive pulmonary disease. Cibenzoline is a class I antiarrhythmic agent currently undergoing clinical investigation in the U.S. The initial hypoglycemic episode occurred after two years of successful treatment with cibenzoline. Blood glucose during the first hypogly

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S., Vijayakumar. "HYPOGLYCEMIC EFFECT OF BANANA FLAVONOIDS." International Journal of Zoology and Applied Biosciences 4, no. 4 (2019): 162–65. https://doi.org/10.5281/zenodo.3370307.

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Banana flavonoids constitute one of the largest groups of naturally occurring phenols. They are ubiquitous in all parts of green plants and as such are likely to be encountered in any work involving plants extracts. Hypoglycemic effects of banana flavonoids have been reported by many investigators. In this study, the relationship between polyphenol intake and the blood glucose response in healthy and diabetic volunteers was examined and reported the hypoglycemic activity of flavonoids. The present investigation demonstrates that flavonoids isolated from raw banana inhibit the elevation of bloo

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Volchegorsky, I. A., V. Е. Tseilikman, O. L. Kolesnikov, et al. "Hypoglycemic effect of stress exposures and their use for experimental prevention of diabetes mellitus." Problems of Endocrinology 41, no. 6 (1995): 38–42. http://dx.doi.org/10.14341/probl11494.

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The effects of acute and chronic immobilization stress and of a biogenic stressor, prooxidant (neutrophilokin) on the level of glycemia and resistance to diabetogenic exposures were studied in rats. A relationship between the poststress changes in glycemia and the regime of food intake has been revealed: acute stress on an empty stomach led to hypoglycemia, whereas stress without alimentary deprivation caused hyperglycemia. Prestress of fed animals abolished the hypoglycemic effect of stress on an empty stomach and transformed it into a hyperglycemic reaction which could be prevented by obsida

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el-Tayeb, K. M., P. L. Brubaker, H. L. Lickley, E. Cook, and M. Vranic. "Effect of opiate-receptor blockade on normoglycemic and hypoglycemic glucoregulation." American Journal of Physiology-Endocrinology and Metabolism 250, no. 3 (1986): E236—E242. http://dx.doi.org/10.1152/ajpendo.1986.250.3.e236.

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By use of the opiate antagonist naloxone, we have examined the hormonal and metabolic responses to opiate-receptor blockade under basal conditions and during insulin-induced hypoglycemia in normal dogs. Naloxone treatment had no measurable effect on glucose concentration, turnover, and norepinephrine levels, but stimulated plasma epinephrine, glucagon, and cortisol and inhibited insulin release. Insulin (7 mU X kg-1 X min-1) decreased plasma glucose to 42 +/- 4 mg/dl due to an initial decrease in glucose production and an increase in glucose disappearance. Glucose production then increased, an

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Egshatyan, L. V. "Sitagliptin: the fixed combination of the first dipeptidyl peptidase 4 inhibitor and metformin." Meditsinskiy sovet = Medical Council, no. 13 (August 19, 2023): 116–21. http://dx.doi.org/10.21518/ms2023-168.

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Worldwide, there is an increasing incidence of type 2 diabetes mellitus (T2DM). Management of patients with T2DM is complex and often requires multiple pharmacological treatments to achieve adequate control of the disease. The long-term diabetes-specific complications have been ameliorated by interventions that decrease chronic glycemia. Most clinical guidelines recommend metformin as the first-line oral hypoglycemic agent. Metformin can be used for monotherapy and combination therapy for T2DM. Initially, metformin monotherapy is often effective, although the effect of glucose control is limit

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Gupta, Ashok Kumar, Mansi Verma, and Gajraj Singh Lodhi. "Protective effect of Ficus infectoria plant extract against fructose induced hyperlipidemia and hyperglycemia in rats." Journal of Phytopharmacology 3, no. 6 (2014): 431–35. http://dx.doi.org/10.31254/phyto.2014.3610.

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The main aim of this study is to explore the antihyperlipidemic and hypoglycemic potential of the methanolic extract of Ficus infectoria in Wistar rats. Hyperlipidemia and hypoglycemia in rats were induced by fructose solution (10% w/v, p.o., ad libitum) for 3rd and 8th weeks respectively. These activities were measured by estimating the triglyceride, total cholesterol, LDL, VLDL, HDL and serum glucose levels. F. infectoria at 200mg/kg and 400mg/kg showed significant effect. Fructose feeding increased serum biochemical parameters like triglyceride, total cholesterol, LDL, VLDL and serum glucos

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Caprio, S., G. Gerety, W. V. Tamborlane, et al. "Opiate blockade enhances hypoglycemic counterregulation in normal and insulin-dependent diabetic subjects." American Journal of Physiology-Endocrinology and Metabolism 260, no. 6 (1991): E852—E858. http://dx.doi.org/10.1152/ajpendo.1991.260.6.e852.

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To examine the impact of opiate blockade on glucose counterregulation we performed two hypoglycemic insulin clamp studies with and without naloxone in healthy subjects and well-controlled insulin-dependent (IDDM) patients with defective glucose counterregulation. During both studies plasma glucose fell to 55-60 mg/dl and was then maintained at that level using a variable glucose infusion. In normal subjects, naloxone increased glucose production, thereby reducing the exogenous glucose dose needed to maintain the hypoglycemic plateau. Epinephrine and cortisol responses to hypoglycemia were incr

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Fujita, Satoshi, MaryAnn Bohland, Graciela Sanchez-Watts, Alan G. Watts, and Casey M. Donovan. "Hypoglycemic detection at the portal vein is mediated by capsaicin-sensitive primary sensory neurons." American Journal of Physiology-Endocrinology and Metabolism 293, no. 1 (2007): E96—E101. http://dx.doi.org/10.1152/ajpendo.00415.2006.

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To elucidate the type of spinal afferent involved in hypoglycemic detection at the portal vein, we considered the potential role of capsaicin-sensitive primary sensory neurons. Specifically, we examined the effect of capsaicin-induced ablation of portal vein afferents on the sympathoadrenal response to hypoglycemia. Under anesthesia, the portal vein was isolated in rats and either capsaicin (CAP) or the vehicle (CON) solution applied topically. During the same surgery, the carotid artery (sampling) and jugular vein (infusion) were cannulated. One week later, all animals underwent a hyperinsuli

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Fabris, Chiara, Leon S. Farhy, Stacey M. Anderson, Ralf M. Nass, Boris P. Kovatchev, and Marc D. Breton. "Recent Exposure to Hypoglycemia Increases Glucose Variability Following a Hyper/Hypoglycemic Metabolic Challenge in T1D." Journal of Diabetes Science and Technology 12, no. 2 (2017): 311–17. http://dx.doi.org/10.1177/1932296817729392.

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Aims: In type 1 diabetes (T1D), repeated hypoglycemic episodes may reduce hormonal defenses and increase the risk for severe hypoglycemia. In this work, we investigate the effect of a structured hyper/hypoglycemic metabolic challenge on the postintervention glucose variability in T1D subjects studied at home. Methods: Thirty T1D subjects using insulin pump were monitored with blood glucose meters (SMBG) during a 1-month observation period. After 2 weeks of monitoring, participants were admitted at the University of Virginia Clinical Research Unit to undergo an 8-hour metabolic challenge. The i

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