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Journal articles on the topic 'Hypoglycemic properties'

Author: Grafiati

Published: 7 June 2025

Last updated: 2 August 2025

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1

Pashkova, E. Iu. "The new therapeutic modalities for the treatment of type 2 diabetes mellitus: insulin detemir added to liraglutide." Problems of Endocrinology 59, no. 4 (2013): 50–55. http://dx.doi.org/10.14341/probl201359450-55.

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he literature data on the effectiveness and safety of the essentially new scheme of hypoglycemic therapy of type 2 diabetes mellitus are presented, The large-scale 52 week study has demonstrated that the addition of insulin detemir to the preceding treatment with liraglutide makes it possible to reach and maintain glycated hemoglobin percentage at the desired level of 7% in 43% of the patients. The risk of development of hypoglycemia was estimated at 0.286 episodes per patient per year in the absence of body weight increment. The combination of these two medications was found to produce pronou

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2

Petunina, N. A., N. S. Martirosian, E. V. Goncharova, et al. "The place of gliclazide MB in modern treatment strategies for patients with type 2 diabetes mellitus." Diabetes mellitus 27, no. 4 (2024): 368–75. http://dx.doi.org/10.14341/dm13184.

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Sulfonylurea (SU) are an effective class of oral hypoglycemic drugs that have been used in clinical practice for more than 70 years. Despite the common mechanism of action, members of the class have significant intraclass differences in hypoglycemic activity, safety, and the presence of extrapancreatic effects. This review examines the features of gliclazide modified release (MR), its differences from other representatives of the SU and its place in modern recommendations for the treatment of type 2 diabetes mellitus. Gliclazide MR belongs to the modern 2nd generation SU with high hypoglycemic

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3

Koussoube, Abdelaziz, Filkpièrè Léonard DA, Maya Doukoure, et al. "Assessment of antioxidant activity and hypoglycemic and anti-hyperglycemic effects of the hydroethanolic extract of the trunk bark of Lannea acida A. Rich. (Anacardiaceae) in male NMRI mice." International Journal of Research in Pharmaceutical Sciences 16, no. 2 (2025): 61–69. https://doi.org/10.26452/ijrps.v16i2.4755.

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Lannea acida A. Rich (Anacardiaceae) is a plant widely used in African traditional medicine to treat various ailments, including diabetes and infertility. This study aimed to evaluate the antioxidant, hypoglycemic, and anti-hyperglycemic activities of the hydroethanolic extract from its trunk bark in male NMRI mice. Antioxidant activity was assessed using DPPH (2,2-diphenyl-1-picrylhydrazyl) and ferric reducing antioxidant power (FRAP) assays. Hypoglycemic effects were tested in fasting normoglycemic mice divided into five groups (n=5). The anti-hyperglycemic activity was evaluated via an oral

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4

Borisov, Sergey A., Olga A. Luzina, Mikhail V. Khvostov, Tatiana G. Tolstikova, and Nariman F. Salakhutdinov. "Synthesis and Pharmacological Evaluation of (+)-Usnic Acid Derivatives as Hypoglycemic Agents." Molbank 2022, no. 4 (2022): M1459. http://dx.doi.org/10.3390/m1459.

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Usnic acid is produced by lichens and exhibits different biological properties, including hypoglycemic ones. However, this effect becomes noticeable only at relatively high doses, something that may lead to some adverse effects. The chemical modification of the molecule is able to enhance its safety profile and its hypoglycemic properties. We synthesized six enamine derivatives of (+)-usnic acid, and two of them are novel. All compounds were evaluated for the hypoglycemic effect after oral introduction in mice with alloxan-induced diabetes mellitus at a dose of 50 mg/kg. The derivative contain

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5

Hu, Fangdi, Xiaodong Li, Lianggong Zhao, Shilan Feng, and Chunming Wang. "Antidiabetic properties of purified polysaccharide fromHedysarum polybotrys." Canadian Journal of Physiology and Pharmacology 88, no. 1 (2010): 64–72. http://dx.doi.org/10.1139/y09-098.

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Hedysarum polybotrys polysaccharide (HPS) is the principal active fraction responsible for the antidiabetic properties of this species. The aim of this study was to determine the antidiabetic properties of 4 purified fractions of different molecular weight range HPSs (HPS1, HPS2, HPS3, HPS4). HPS3 was selected for examination of its hypoglycemic mechanism because of its significant hypoglycemic effect in alloxan-induced diabetic mice. The changes in blood glucose levels and oral glucose tolerance tests (OGTT) showed that hypoglycemia was more pronounced in HPS3-treated groups than in the diabe

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6

Tan, Seok-Tyug, and Seok-Shin Tan. "A review on the hypoglycemic properties of selected non-leafy vegetables in Malaysia." Nutrition & Food Science 49, no. 6 (2019): 1113–25. http://dx.doi.org/10.1108/nfs-10-2018-0280.

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Purpose Non-communicable diseases such as type 2 diabetes, hypertension, cancers and cardiovascular diseases have become a major health concern globally. As literature claims that frequent consumption of fruits and vegetables can delay the onset of type 2 diabetes and its complications, this paper aims to evaluate the potential hypoglycemic properties in five types of non-leafy vegetables (pumpkin, sweet potato, bitter gourd, onion and lady’s finger), which are commonly available in Malaysia. Design/methodology/approach Articles were identified through several main search engines, including Pu

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7

Iranmanesh, Ali, German Lizarralde та Johannes D. Veldhuis. "Coordinate activation of the corticotropic axis by insulin-induced hypoglycemia: simultaneous estimates of β-endorphin, adrenocorticotropin and cortisol secretion and disappearance in normal men". Acta Endocrinologica 128, № 6 (1993): 521–28. http://dx.doi.org/10.1530/acta.0.1280521.

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In the present study, we investigated the coordinate kinetic response of the corticotropic axis to the acute metabolic stress of hypoglycemia by applying deconvolution analysis to adrenocorticotropin (ACTH), β-endorphin and cortisol concentration-time series generated in seven normal men after intravenous administration of insulin. Hypoglycemic stress resulted in a 22-fold increase in the mean plasma concentration of ACTH to a maximum of 77±15 pmol/l, in conjunction with a 7.5-fold increase in the mean plasma β-endorphin concentration, the maximal value of which was 96±11 pmol/l. Plasma cortis

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8

Zhu, Jiangxiong, Hui Zhou, Junyao Zhang, et al. "Valorization of Polysaccharides Obtained from Dark Tea: Preparation, Physicochemical, Antioxidant, and Hypoglycemic Properties." Foods 10, no. 10 (2021): 2276. http://dx.doi.org/10.3390/foods10102276.

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The structure and hypoglycemic activity of tea polysaccharides has been extensively studied, while there are few reports on the characterization and hypoglycemic activity of dark tea polysaccharides. The crude dark tea polysaccharide (CDTPS) was optimally extracted from Fuzhuan dark tea. Six polysaccharide fractions (namely DTPS-1, DTPS-2, DTPS-3, DTPS-4, DTPS-5, and DTPS-6) were isolated from CDTPS, and their physicochemical, structural, and biological properties were compared and analyzed. The results revealed that the compositions, structural characteristics, and biological properties of th

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9

Eremina, Natalia V., Aliy K. Zhanataev, Artem A. Lisitsyn, and Andrey D. Durnev. "Genotoxic properties of hypoglycemic drugs (systematic review)." Ecological genetics 19, no. 3 (2021): 219–40. http://dx.doi.org/10.17816/ecogen70691.

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According to the literature genotoxic properties of about a half of hypoglycemic drugs have not been investigated in accordance with the recommended methodology, and studies of the mutagen-modifying activity of antidiabetic drugs are sporadic. Based on the available published data, it is impossible to conclude about either presence or absence of genotoxic / antigenotoxic potential of antidiabetic drugs. There is evidence of the antimutagenic activity of metformin; in relation to other drugs, studies of mutagen-modifying activity have not been carried out or are represented only by a few articl

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10

Dasgupta, Tumpa, Amlan Ganguly, Muhammad Asaduzzaman, and Nazmul Qais. "Evaluation of Anti-microbial, Hypoglycemic and Anti-diarrheal activities of Setaria italica Seeds." Dhaka University Journal of Pharmaceutical Sciences 15, no. 1 (2016): 31–35. http://dx.doi.org/10.3329/dujps.v15i1.29190.

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The ethanolic crude extract of Setaria italica seeds (Poaceae) was investigated for its possible anti-microbial, hypoglycemic and anti-diarrheal activities. Anti-microbial activity was evaluated by disc diffusion method while the hypoglycemic and anti-diarrheal properties were determined by oral glucose tolerance test and castor oil induced diarrheal method, respectively in Albino mice. The ethanolic extract and its different fractions of S. italica have shown good antimicrobial activity against gram negative bacteria having zone of inhibition 9-13 mm (ciprofloxacin: 40- 41 mm). In evaluation

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11

Voĭchik, É. A. "Victosa: the experience with clinical application in patients with type 2 diabetes mellitus." Problems of Endocrinology 57, no. 3 (2011): 37–41. http://dx.doi.org/10.14341/probl201157337-41.

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Type 2 diabetes mellitus that comes from insulin resistance and deficit of insulin secretion has recently been described as associated with reduced incretin effect. The efficiency of traditional hypoglycemic therapy (metformin, secretagogues, glitazones, insulin) gradually decreases due to progressive loss of functioning beta-cell mass. The achievement of target blood glucose levels for the prevention of complications and cardiovascular pathology as a rule leads to such adverse events as increased body weight and hypoglycemia. The search for an «ideal» drug included the study and the use of in

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12

Dervişoğlu, Merve, Dilek Büyükkaya Besen, Merve Günbaş, Mehtap Ertaş, and Barış Emekdaş. "A Psychometric Evaluation of the Hypoglycemia Problem-Solving Scale (HPSS) in Turkish Older Adults with Diabetes." Healthcare 13, no. 9 (2025): 997. https://doi.org/10.3390/healthcare13090997.

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Introduction: Hypoglycemia is a significant complication in diabetes management and presents an even greater risk for older adults. These individuals are particularly vulnerable to hypoglycemic episodes, which can result in serious health consequences. The Hypoglycemia Problem-Solving Scale (HPSS) evaluates problem-solving skills related to hypoglycemia; however, it has not yet been validated in Türkiye. This study aimed to evaluate the validity and reliability of the Turkish adaptation of the HPSS. Materials and Methods: A descriptive, methodological, and cross-sectional study was conducted w

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13

Yu, Songfeng, Wenjun Wang, Shanshan Li, et al. "Glucoregulatory Properties of Fermented Soybean Products." Fermentation 9, no. 3 (2023): 254. http://dx.doi.org/10.3390/fermentation9030254.

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Type 2 diabetes mellitus is a chronic metabolic disease, characterized by persistent hyperglycemia, the prevalence of which is on the rise worldwide. Fermented soybean products (FSP) are rich in diverse functional ingredients which have been shown to exhibit therapeutic properties in alleviating hyperglycemia. This review summarizes the hypoglycemic actions of FSP from the perspective of different target-related molecular signaling mechanisms in vitro, in vivo and clinical trials. FSP can ameliorate glucose metabolism disorder by functioning as carbohydrate digestive enzyme inhibitors, facilit

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14

Ruiatkina, L. A., and M. Iu Sorokin. "Detemir (Levemir): modern paradigms of insulin therapy." Problems of Endocrinology 59, no. 4 (2013): 56–64. http://dx.doi.org/10.14341/probl201359456-64.

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Peculiarities of the molecular structure of Levemir (detemir) account for low variability of its pharmacodynamic properties and are responsible for the more predictable hypoglycemic effect and the lower risk of general and nocturnal hypoglycemic episodes in different age-groups of the patents suffering type 1 and 2 diabetes mellitus compared with other preparations of basal insulin. Moreover, insulin detemir (Levemir) does not affect the body weight of the patients due to its central action (rapid penetration across the hematoencephalic barrier, control of hunger and satiation, improved recogn

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15

Liu, Mengyi, Chunlong Liu, Puba Zhaxi, Xiaohong Kou, Yazhou Liu, and Zhaohui Xue. "Research Progress on Hypoglycemic Effects and Molecular Mechanisms of Flavonoids: A Review." Antioxidants 14, no. 4 (2025): 378. https://doi.org/10.3390/antiox14040378.

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As a prevalent metabolic disorder, the increasing incidence of diabetes imposes a significant burden on global healthcare. Flavonoids in natural phytochemical products exhibit notable hypoglycemic properties, making them potential alternatives for diabetes treatment. This article summarizes the hypoglycemic properties of flavonoid subcategories studied in recent years, including flavones, isoflavones, flavonols, flavanols, and others. The relevant targets and signal pathways, such as α-amylase, α-glucosidase, insulin receptor substrate (IRS)/phosphatidylinositol 3-kinase (PI3K)/protein kinase

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16

Urzêda, Márcio A., Silvana Marcussi, Luciana L. Silva Pereira, et al. "Evaluation of the Hypoglycemic Properties ofAnacardium humileAqueous Extract." Evidence-Based Complementary and Alternative Medicine 2013 (2013): 1–8. http://dx.doi.org/10.1155/2013/191080.

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The antihyperglycemic effects of several plant extracts and herbal formulations which are used as antidiabetic formulations have been described and confirmed to date. The main objective of this work was to evaluate the hypoglycemic activity of the aqueous extract ofAnacardium humile. Although the treatment of diabetic animals withA. humiledid not alter body weight significantly, a reduction of the other evaluated parameters was observed. Animals treated withA. humiledid not show variation of insulin levels, possibly triggered by a mechanism of blood glucose reduction. Levels of ALT (alanine am

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17

Tursunova. "The Hypoglycemic Properties of BAE Maca Max Preparation." OnLine Journal of Biological Sciences 9, no. 1 (2009): 17–20. http://dx.doi.org/10.3844/ojbs.2009.17.20.

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18

Krizhanovsky. "The Hypoglycemic Properties of BAE Maca Max Preparation." OnLine Journal of Biological Sciences 9, no. 1 (2009): 17–20. http://dx.doi.org/10.3844/ojbsci.2009.17.20.

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19

Wanniarachchi, Binuki, H. M. W. K. Sathsarani, Bimali M. Jayawardena, and H. G. N. Dewangani. "Synthesis and Characterization of Cinnamon Loaded BSA Microparticles with Antidiabetic Properties." Biology, Medicine, & Natural Product Chemistry 12, no. 1 (2023): 241–50. http://dx.doi.org/10.14421/biomedich.2023.121.241-250.

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Conventional medicine that is being used to treat diabetes exert adverse side effects and therefore scientists have focused on natural hypoglycemic agents. “Sri Wijaya” (CCSW) is an accession of Cinnamomum zeylanicum, which shows higher hypoglycemic activity. Pressured water extract of its dried quills can be used as an antidiabetic nutraceutical. Higher stability, ease of storage and transportation, make powder form nutraceuticals more preferred. The objective of this study was to develop cinnamon encapsulated microparticles as a powder form nutraceutical with higher hypoglycemic activity. Fo

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20

Hasan, Md Sharif, Narhari Das, Zobaer Al Mahmud, and S. M. Abdur Rahman. "Pharmacological Evaluation of Naproxen Metal Complexes on Antinociceptive, Anxiolytic, CNS Depressant, and Hypoglycemic Properties." Advances in Pharmacological Sciences 2016 (2016): 1–7. http://dx.doi.org/10.1155/2016/3040724.

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Purpose. The present study was designed to investigate the antinociceptive, anxiolytic, CNS depressant, and hypoglycemic effects of the naproxen metal complexes.Methods. The antinociceptive activity was evaluated by acetic acid-induced writhing method and radiant heat tail-flick method while anxiolytic activity was evaluated by elevated plus maze model. The CNS depressant activity of naproxen metal complexes was assessed using phenobarbitone-induced sleeping time test and the hypoglycemic test was performed using oral glucose tolerance test.Results. Metal complexes significantly (P<0.001) r

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21

Lohray, Braj B., and Vidya Lohray. "Novel pyrrole-containing hypoglycemic and hypotriglyceridemic compounds." Pure and Applied Chemistry 77, no. 1 (2005): 179–84. http://dx.doi.org/10.1351/pac200577010179.

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Several substituted α-alkoxy phenyl propionic acids were synthesized, and their hypotriglyceridemic properties were evaluated in Swiss albino mice. Some of the compounds showed excellent triglyceride- and cholesterol-lowering properties even at a dose of 1 mg/kg. 2,5-Substituted pyrrole-containing heterocycles were among the most potent alkoxy propionic acid class of compounds. These compounds also showed excellent antidiabetic activities in animal models.

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22

Le, Minh Hoang, Huyen Sanh Sam, Duy Toan Pham, Ngoc Chi Lan Nguyen, Ngoc Diem Le, and Tran Nhat Phong Dao. "Ngu-Vi-Tieu-Khat decoction, a Vietnamese traditional medicine, possesses hypoglycemic and hypolipidemic effects on streptozotocin-induced type-2 diabetic rat model." Pharmacia 70, no. 4 (2023): 943–50. http://dx.doi.org/10.3897/pharmacia.70.e108879.

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This study aims to assess the hypoglycemic effects of Ngu-Vi-Tieu-Khat (NVTK) decoction, a traditional Vietnamese medicine, in a rat model of type-2 diabetes. The NVTK decoction was prepared using the maceration method and tested for its hypoglycemic effects by measuring blood glucose levels, insulin resistance indicators, and pancreatic mass. The results showed that NVTK decoction improved diabetes symptoms, increased insulin levels, reduced insulin resistance, restored pancreatic mass, and decreased total cholesterol (TC), triglycerides (TG) and low-density lipoprotein cholesterol (LDL-C) wh

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23

Le, Minh Hoang, Huyen Sanh Sam, Duy Toan Pham, Ngoc Chi Lan Nguyen, Ngoc Diem Le, and Tran Nhat Phong Dao. "Ngu-Vi-Tieu-Khat decoction, a Vietnamese traditional medicine, possesses hypoglycemic and hypolipidemic effects on streptozotocin-induced type-2 diabetic rat model." Pharmacia 70, no. (4) (2023): 943–50. https://doi.org/10.3897/pharmacia.70.e108879.

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This study aims to assess the hypoglycemic effects of Ngu-Vi-Tieu-Khat (NVTK) decoction, a traditional Vietnamese medicine, in a rat model of type-2 diabetes. The NVTK decoction was prepared using the maceration method and tested for its hypoglycemic effects by measuring blood glucose levels, insulin resistance indicators, and pancreatic mass. The results showed that NVTK decoction improved diabetes symptoms, increased insulin levels, reduced insulin resistance, restored pancreatic mass, and decreased total cholesterol (TC), triglycerides (TG) and low-density lipoprotein cholesterol (LDL-C) wh

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24

Kuranov, Sergey, Olga Luzina, Mikhail Khvostov, et al. "Bornyl Derivatives of p-(Benzyloxy)Phenylpropionic Acid: In Vivo Evaluation of Antidiabetic Activity." Pharmaceuticals 13, no. 11 (2020): 404. http://dx.doi.org/10.3390/ph13110404.

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A series of bornyl derivatives of p-(benzyloxy)phenylpropionic acid were prepared, and their hypoglycemic activities were examined by an oral glucose tolerance test in mice. The results of this test revealed two compounds, 1 and 3, that can reduce the blood level of glucose similarly to reference compound vildagliptin. Both compounds were tested in an experiment on mice with metabolic disorders: the C57BL/6Ay strain. Along with hypoglycemic properties, the two compounds showed different abilities to correct lipid metabolism disorders. In silico prediction revealed that the studied substances a

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25

Liu, Chuan, Yu Miao, Wenjia Zhou, Yiming Ma, Wenkui Guo, and Aili Li. "Impact of Thermal Processing on the Structure, Antioxidant Properties and Hypoglycemic Activities of Sweet Potato Polysaccharides." Foods 13, no. 19 (2024): 3082. http://dx.doi.org/10.3390/foods13193082.

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In this study, three kinds of thermal treatments were applied to sweet potatoes: steaming (100 °C, 20 min), frying (150 °C, 10 min), and baking (200 °C, 30 min). We analyzed the changes in the physicochemical structure, antioxidant properties, and hypoglycemic activities of sweet potato polysaccharides between untreated and heat-treated samples. The results showed that the polysaccharides of all sweet potatoes (untreated and heat-treated) were composed of pyranose structures, had low protein content, and shared the same monosaccharide composition. Infrared spectra showed that the three thermal

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26

Zhou, Fating, Di Li, Yakun Hou, et al. "Exploration of hypoglycemic peptides from porcine collagen based on network pharmacology and molecular docking." PLOS ONE 19, no. 3 (2024): e0298674. http://dx.doi.org/10.1371/journal.pone.0298674.

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In recent years, the extraction of hypoglycemic peptides from food proteins has gained increasing attention. Neuropeptides, hormone peptides, antimicrobial peptides, immune peptides, antioxidant peptides, hypoglycemic peptides and antihypertensive peptides have become research hotspots. In this study, bioinformatic methods were used to screen and predict the properties of pig collagen-derived hypoglycemic peptides, and their inhibitory effects on α-glucosidase were determined in vitro. Two peptides (RL and NWYR) were found to exhibit good water solubility, adequate ADMET (absorption, distribut

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27

Kaundinnyayana, Atisammodavardhana, Anita G.C, Asmita Banstola, Kishwor Poudel, Nirmal Acharya, and Sanjay Koirala. "Antioxidant and Hypoglycemic Properties of Seeds of Cucurbitaceae Family from Western Nepal." Journal of Health and Allied Sciences 9, no. 2 (2019): 1–5. http://dx.doi.org/10.37107/jhas.118.

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Introduction: Diabetes mellitus is an endocrine and metabolic disorder characterized by the defect in insulin secretion or insulin action or both. The association between diabetes mellitus and oxidative stress is well established. Cucurbitaceae is the largest family containing 120 genera mostly grown for its sweet and juicy fruit in warm climates all over the world. In the present work ethanolic extracts of the seeds of Trichosanthes cucumerina Linn (Chichinno), Lagenaria siceraria (Lauka), Cucurbita pepo (Pharsi), Luffa aegiptiaca (Ghiraula), and Benincasa hispida (Kubindo) collected from Wes

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28

Won, GaYeong, Soo-Im Choi, NaYeong Park, Ji-Eun Kim, Chang-Ho Kang, and Gun-Hee Kim. "In Vitro Antidiabetic, Antioxidant Activity, and Probiotic Activities of Lactiplantibacillus plantarum and Lacticaseibacillus paracasei Strains." Current Microbiology 78, no. 8 (2021): 3181–91. http://dx.doi.org/10.1007/s00284-021-02588-5.

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AbstractDiabetes, a chronic metabolic disorder, is characterized by persistent hyperglycemia. This study aimed to evaluate the hypoglycemic and antioxidant activities of lactic acid bacteria strains isolated from humans and food products and investigate the probiotic properties of the selected four strains. The hypoglycemic activity of the isolated strains was examined by evaluating the α-glucosidase and α-amylase inhibitory activities. The antioxidant activity was measured using the DPPH, ABTS, and FRAP assays. Four strains (Lactiplantibacillus plantarum MG4229, MG4296, MG5025, and Lacticasei

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29

You, Yuming, Ting Ren, Shiqi Zhang, Gerald Gasper Shirima, YaJiao Cheng, and Xiong Liu. "Hypoglycemic effects of Zanthoxylum alkylamides by enhancing glucose metabolism and ameliorating pancreatic dysfunction in streptozotocin-induced diabetic rats." Food & Function 6, no. 9 (2015): 3144–54. http://dx.doi.org/10.1039/c5fo00432b.

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Widowati, Sri, Made Astawan, Deddy Muchtadi, and Tutik Wresdiyati. "HYPOGLYCEMIC ACTIVITY OF SOME INDONESIAN RICE VARIETIES AND THEIR PHYSICOCHEMICAL PROPERTIES." Indonesian Journal of Agricultural Science 7, no. 2 (2016): 57. http://dx.doi.org/10.21082/ijas.v7n2.2006.57-66.

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Diabetes mellitus is a spectrum of inherited and acquired disorders characterized by elevating blood glucose levels. Diabetes is an abnormal carbohydrate metabolism, therefore, diet therapy for diabetics plays a key role in the management of the disease. Most Indonesian people consume rice as source of energy and protein. Generally, diabetics consume very limited rice because they believe that rice is the one of hyperglycemic food, even though different rice varieties have large range of glycemic index. The study aimed to evaluate hypoglycemic properties by using rat assay and chemical charact

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31

Widowati, Sri, Made Astawan, Deddy Muchtadi, and Tutik Wresdiyati. "HYPOGLYCEMIC ACTIVITY OF SOME INDONESIAN RICE VARIETIES AND THEIR PHYSICOCHEMICAL PROPERTIES." Indonesian Journal of Agricultural Science 7, no. 2 (2016): 57. http://dx.doi.org/10.21082/ijas.v7n2.2006.p57-66.

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Diabetes mellitus is a spectrum of inherited and acquired disorders characterized by elevating blood glucose levels. Diabetes is an abnormal carbohydrate metabolism, therefore, diet therapy for diabetics plays a key role in the management of the disease. Most Indonesian people consume rice as source of energy and protein. Generally, diabetics consume very limited rice because they believe that rice is the one of hyperglycemic food, even though different rice varieties have large range of glycemic index. The study aimed to evaluate hypoglycemic properties by using rat assay and chemical charact

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32

Demidova, T. Yu. "Long-term prospects of therapy with dipeptidyl peptidase-4 inhibitors in patients with type 2 diabetes mellitus." FOCUS. Endocrinology 6, no. 1 (2025): 37–42. https://doi.org/10.62751/2713-0177-2025-6-1-05.

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Currently, dipeptidyl peptidase-4 inhibitors (gliptins) consistently occupy an increasingly important place in the arsenal of endocrinologists worldwide and are considered one of the most promising classes of hypoglycemic agents. According to the results of numerous studies among representatives of this group, vildagliptin demonstrates the greatest eﬃcacy and safety in the treatment of type 2 diabetes mellitus, which, in addition to its sugar-lowering eﬀect, has a positive eﬀect on the cardiovascular system in the long term, has a beneﬁcial eﬀect on blood pressure, exhibits cardioprotective pr

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33

Zhang, Kun, Mei Han, Xia Zhao, et al. "Hypoglycemic and Antioxidant Properties of Extracts and Fractions from Polygoni Avicularis Herba." Molecules 27, no. 11 (2022): 3381. http://dx.doi.org/10.3390/molecules27113381.

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Our research focused on the hypoglycemic capability and the possible mechanisms of extract and fractions from Polygoni Avicularis Herba (PAH) based on α-glucosidase, α-amylase inhibition assays, glucose uptake experiment, HPLC-MS analysis, and molecular docking experiment. In addition, DPPH, ABTS, and FRAP assays were used for determining the antioxidant capability. The results of total flavonoids and phenolics contents showed that ethyl acetate fraction (EAF) possessed the highest flavonoids and phenolics with values of 159.7 ± 2.5 mg rutin equivalents/g and 107.6 ± 2.0 mg galic acid equivale

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Tan, Seok-Tyug, Amin Ismail, Muhajir Hamid, Pei-Pei Chong, Jian Sun, and Seok-Shin Tan. "Phytochemicals derived from soya bean husk exert hypoglycemic and anti-adipogenic properties in cell culture models." Nutrition & Food Science 49, no. 6 (2019): 1219–31. http://dx.doi.org/10.1108/nfs-12-2018-0351.

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Purpose Literature has shown that phenolic acids and flavonoids are bearing with hypoglycemic and anti-adipogenic properties. Therefore, this study aims to evaluate the possibility of phenolic-rich soya bean husk powder extract (SHPE) in combating diabetes and obesity using in vitro models. Design/methodology/approach The hypoglycemic properties were evaluated by determining the ability of SHPE (25-100 µg/mL) in inhibiting a-amylase and a-glucosidase enzymes and in triggering insulin secretion in BRIN-BD11 cells. Murine 3T3-L1 adipocytes were used for evaluating the anti-adipogenic properties

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35

Eremenko, R. F., L. N. Maloshtan, and E. Yu Yatsenko. "Experimental study of hypoglycemic effect of medicago sativa leaves extract." Kazan medical journal 95, no. 4 (2014): 557–61. http://dx.doi.org/10.17816/kmj1843.

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Aim. To study the hypoglycemic effect of the Medicago Sativa leaves extract in intact rats and in rats with a glucose load. Methods. At the first stage, hypoglycemic effect of Medicago Sativa leaves extract was determined in intact rats. 50 mg/kg of metformin and 18 mg/kg of herbal anti-diabetic «Arfazetin» tea were used as comparator drugs. At the second stage, hypoglycemic effect of Medicago Sativa leaves extract was determined in rats with glucose load. Blood samples for glucose analysis were taken before and in 15, 30, 60 and 120 minutes after loading. Blood glucose level was determined by

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Moretto, Giulia, Raffaella Colombo, Stefano Negri, Hellas Cena, Lorena Vailati, and Adele Papetti. "Italian Biodiversity: A Source of Edible Plant Extracts with Protective Effects Against Advanced Glycation End Product-Related Diseases." Nutrients 17, no. 6 (2025): 935. https://doi.org/10.3390/nu17060935.

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Background: Italy’s plant biodiversity, characterized by many plant species, is an important source of bioactive secondary metabolites that help reduce the risk of the development of advanced glycation end product (AGE)-related diseases. AGEs are involved in various diseases, such as diabetes, cardiovascular, and neurodegenerative disorders. Therefore, the aim of the study was to investigate the antiglycative, hypoglycemic, and neuroprotective properties of nine edible plant extracts using different in vitro assays. Methods: The ability of the extracts to counteract AGE formation was evaluated

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Moqbel, Fahmi S., and Prakash R. Naik. "Effect of different fractions of Hibiscus rosa sinensis leaf extract on islets of Langerhans and antioxidant activity in non-obese diabetic (NOD) mouse." Journal of Applied and Natural Science 3, no. 2 (2011): 206–10. http://dx.doi.org/10.31018/jans.v3i2.180.

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The present investigation was undertaken to study the effect of Hibiscus rosa sinensis leaf extract fractions on islets of Langerhans, total antioxidant activity in non-obese diabetic (NOD) mouse. Two sets of experiments were conducted. First experiment was designed to test the hypoglycemic properties of different isolated fractions. Five fractions were screened for hypoglycemic property. Fractions F3, F4 and F5 showed hypoglycemic in NOD mice. Second set of experiment was conducted to assess the effects of above fractions on the diameter of islets of Langerhans and on the â-cells number and t

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Yudhani, Ratih Dewi, Dwi Aris Agung Nugrahaningsih, Eti Nurwening Sholikhah, and Mustofa Mustofa. "The Molecular Mechanisms of Hypoglycemic Properties and Safety Profiles of Swietenia Macrophylla Seeds Extract: A Review." Open Access Macedonian Journal of Medical Sciences 9, F (2021): 370–88. http://dx.doi.org/10.3889/oamjms.2021.6972.

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BACKGROUND: Insulin resistance (IR) is known as the root cause of type 2 diabetes; hence, it is a substantial therapeutic target. Nowadays, studies have shifted the focus to natural ingredients that have been utilized as a traditional diabetes treatment, including Swietenia macrophylla. Accumulating evidence supports the hypoglycemic activities of S. macrophylla seeds extract, although its molecular mechanisms have yet to be well-established. AIM: This review focuses on the hypoglycemic molecular mechanisms of S. macrophylla seeds extract and its safety profiles. METHODS: An extensive search o

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Demidova, Tatiana Y., and Olga V. Balutina. "Special aspects of concentrated insulins: basic characteristics and research findings." Diabetes mellitus 22, no. 5 (2020): 481–90. http://dx.doi.org/10.14341/dm10334.

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The appearance of concentrated insulins in clinical practice determines the need to analyze product priorities in appropriate groups of patients with diabetes. The aim of this article is to summarize the literature on concentrated insulins (i.e. insulin lispro 200 units/mL, insulin degludec 200 units/mL, insulin glargine 300 units/mL) from randomized controlled trials, derive guidance on appropriate and safe use of these agents and demonstrate experience in real clinical practice. Severe hypoglycemia in all studies was generally low (though higher with prandial plus concentrated basal analogue

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Niu, Yuge. "Introduction to the Special Issue: Preparation, Physicochemical Properties and Application of Natural Plant Polysaccharides." Foods 12, no. 13 (2023): 2457. http://dx.doi.org/10.3390/foods12132457.

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As natural products, plant polysaccharides have been demonstrated to induce a variety of biological activities by numerous epidemiological investigations and interventional studies, including immunomodulation and antioxidant, antibacterial, antitumor, hypolipidemic, hypoglycemic processes, etc [...]

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Salukhov, V. V., E. A. Kovalevskaya, and Т. A. Ilyinskaya. "Collaboration of alogliptin and pioglitazone: a double hit on the target." Meditsinskiy sovet = Medical Council, no. 6 (May 18, 2024): 24–35. http://dx.doi.org/10.21518/ms2024-157.

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Diabetes mellitus is not only a problem of hyperglycemia, but is also associated with severe cardiovascular disease and fatal outcomes. Currently, glucose-lowering drugs are considered not only as effective glucose-reducing agents, but also as cardiosafe or even cardioprotective agents. Fixed combinations of glucose-lowering drugs of various groups with combined mechanisms of pharmacological effects on glycemic levels are more effective than monotherapy. The reincarnation of thiazolidinediones has contributed to the creation of various variants of these combinations. The study of the pleiotrop

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Saad Al-Deen Abdul Razzaq Al-hilly, Ali. "Efficacy and safety of adding single dose insulin glargine in patients with type 2 diabetes uncontrolled by oral hypoglycemic drugs." AL-QADISIYAH MEDICAL JOURNAL 14, no. 25 (2018): 27–34. http://dx.doi.org/10.28922/qmj.2018.14.25.27-34.

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Abstract: Unfortunately, a Significant number of type 2 diabetic patients on oral hypoglycemic agents are not achieving the desired and recommended target of glycemic control in terms of reduction of HbA1c and fasting plasma glucose, this is largely because most of them are reluctant to use insulin injections for many reasons, mainly the painful injection, fear of hypoglycemia or inability to adapt to a complex regimen of multiple insulin injections. it has been recommended by many diabetes associations ( the American diabetes association(ADA) and the European association for the study o

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Soto-García, Marcela, Martha Rosales-Castro, Gerardo N. Escalona-Cardoso, and Norma Paniagua-Castro. "Evaluation of Hypoglycemic and Genotoxic Effect of Polyphenolic Bark Extract from Quercus sideroxyla." Evidence-Based Complementary and Alternative Medicine 2016 (2016): 1–7. http://dx.doi.org/10.1155/2016/4032618.

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Quercus sideroxyla is a wood species whose bark has phenolic compound and should be considered to be bioactive; the hypoglycemic and genotoxic properties of Q. sideroxyla bark were evaluated in this study. Total phenolic compound was determined in crude extract (CE) and organic extract (OE). The OE has the highest amount of phenols (724.1±12.0 GAE/g). Besides, both CE and OE demonstrated effect over the inhibition of α-amylase in vitro. Hypoglycemic activity was assessed by glucose tolerance curve and the area under curve (UAC); OE showed the highest hypoglycemic activity. In addition, diabete

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Alvin, G. Domingo, F. Cariaga Jayson, and A. Gamboa Francis. "Evaluation of Momordica cochinchinensis Fruit Methanolic Extract for Potential Medicinal Use." Indian Journal of Science and Technology 16, no. 40 (2023): 3559–66. https://doi.org/10.17485/IJST/v16i40.778.

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Abstract <strong>Objectives:</strong> This study evaluated the biological and pharmacological activities of Momordica cochinchinensis fruit methanolic extract (MCME). <strong>Methods:</strong> The extract was analyzed for its phytochemical constituents and tested for toxicity and antimicrobial properties. The hypoglycemic activity was also evaluated in hyperglycemic mice. <strong>Findings:</strong> The results showed that the extract contained important phytochemical constituents and exhibited antimicrobial activity against S. aureus and E. coli. The extract was found

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Vargas-Arana, Gabriel, Elsa Rengifo-Salgado, and Mario J. Simirgiotis. "Antidiabetic potential of medicinal plants from the Peruvian Amazon: A review." Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas 22, no. 3 (2023): 277–300. http://dx.doi.org/10.37360/blacpma.23.22.3.21.

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Diabetes mellitus is a metabolic disorder characterized by the presence of chronic hyper-glycemia that is accompanied, to a greater or lesser extent, by alterations in the metabolism of carbohydrates, proteins and lipids. It is the leading cause of death in developed countries. Current antidiabetic drug treatments present several adverse effects for which it has started searching for new oral hypoglycemic agents from vegetal species. This review presents the medicinal plants from the Peruvian Amazon used in the treatment of diabetes and a systematic review of their hypoglycemic properties repo

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Sharma, Shweta, and Viveka Katoch. "Anti-Diabetic Properties of Bitter Gourd." International Journal of Economic Plants 7, no. 1 (2020): 021–24. http://dx.doi.org/10.23910/2/2020.0331.

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Bitter gourd (Momordica charantia L.) is a fruit that traditionally believe to have benefits on health. It is a widely used traditional remedy for the treatment of diabetes. Bitter gourd is suggested for hyperglycemia treatment due to its ability to reduce glucose levels in the body. Some of the bioactive compounds present in it possess anti diabetic effects. It contains phytochemicals with anti-diabetic properties such as charantin, p-insulin and vicine. Hypoglycemic effects of bitter gourd have been shown in clinical studies. This review will focus on the hyperglycemic properties of bitter g

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Carlton, Jill, Joanna Leaviss, Frans Pouwer, et al. "The suitability of patient-reported outcome measures used to assess the impact of hypoglycaemia on quality of life in people with diabetes: a systematic review using COSMIN methods." Diabetologia 64, no. 6 (2021): 1213–25. http://dx.doi.org/10.1007/s00125-021-05382-x.

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Abstract Aims/hypothesis It is generally accepted that hypoglycaemia can negatively impact the quality of life (QoL) of people living with diabetes. However, the suitability of patient-reported outcome measures (PROMs) used to assess this impact is unclear. The aim of this systematic review was to identify PROMs used to assess the impact of hypoglycaemia on QoL and examine their quality and psychometric properties. Methods Systematic searches (MEDLINE, EMBASE, PsycINFO, CINAHL and The Cochrane Library databases) were undertaken to identify published articles reporting on the development or val

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Dovbnia, Dmytro, Yuliia Frolova, and Andrii Kaplaushenko. "A study of hypoglycemic activity of acids and salts containing 1,2,4-triazole." Česká a slovenská farmacie 72, no. 3 (2023): 113–24. http://dx.doi.org/10.5817/csf2023-3-113.

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This article presents the study results of the hypoglycemic properties among 1,2,4-triazole derivatives synthesized at the Department of Physical and Colloidal Chemistry of the Zaporizhzhia State Medical University. Today, many people have a sedentary way

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Parisi, Ortensia Ilaria, Mariarosa Ruffo, Fabio Amone, et al. "PDO Rotonda’s Red Eggplant Extract: In vitro Determination of Biological Properties and Minerals Bioaccessibility." Current Nutrition & Food Science 16, no. 1 (2020): 65–74. http://dx.doi.org/10.2174/1573401314666180622110952.

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Background: The Rotonda’s Red Eggplant belongs to the family of Solanum aethiopicum and it is cultivated in a specific area of Potenza (Basilicata, South of Italy) including villages of Rotonda, Viggianello, Castelluccio Superiore and Castelluccio Inferiore. The Red Eggplant cultivated in this area has gained the PDO, “Protected Designation of Origin”. Objective: The aim of this research was to evaluate the use of PDO Rotonda’s Red Eggplant extract as a possible nutraceutical supplement. The antioxidant, antihypertensive, hypoglycemic, and hypolipidemic properties were in vitro evaluated. Meth

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Gnoumou, Edouard, Teeradate Kongpichitchoke, and Ashika Jose. "Effect of Solid-State Fermentation (SSF) on the Antioxidant and Hypoglycemic Activities of Jackfruit (Artocarpus Heterophyllus Lam.) By-Products using Aspergillus Niger, Aspergillus Oryzae and Rhizopus Oryzae." Trends in Sciences 20, no. 10 (2023): 5648. http://dx.doi.org/10.48048/tis.2023.5648.

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The objective of this experiment was to study the effect of Solid-State Fermentation (SSF) on jackfruit by-products using filamentous fungi. Rags from a ripen jackfruit were fermented for 5, 10 and 15 days by Aspergillus niger, Aspergillus oryzae and Rhizopus oryzae at 30 °C. Then the bioactive compounds were extracted using methanol. Total phenolic content, total flavonoid content, antioxidant activity and hypoglycemic activity of each liquid extract were estimated. The results showed significant increase and improvement in the samples in which SSF was applied. The highest total phenolic cont

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